CASC4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)7.80973413
2regulation of T cell tolerance induction (GO:0002664)5.63677009
3positive regulation of cAMP-mediated signaling (GO:0043950)5.43041092
4negative regulation of execution phase of apoptosis (GO:1900118)4.91915593
5cytidine deamination (GO:0009972)4.85253718
6cytidine metabolic process (GO:0046087)4.85253718
7cytidine catabolic process (GO:0006216)4.85253718
8mitochondrial calcium ion transport (GO:0006851)4.77537595
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.76144761
10DNA deamination (GO:0045006)4.72800831
11positive regulation of B cell differentiation (GO:0045579)4.69442724
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.61423041
13proteasome assembly (GO:0043248)4.58775618
14regulation of tolerance induction (GO:0002643)4.54580882
15positive regulation of gamma-delta T cell activation (GO:0046645)4.47145213
16Arp2/3 complex-mediated actin nucleation (GO:0034314)4.46998815
17regulation of B cell differentiation (GO:0045577)4.38784593
18negative T cell selection (GO:0043383)4.36408288
19positive regulation of tolerance induction (GO:0002645)4.34715768
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.29753171
21cytolysis (GO:0019835)4.03787401
22regulation of B cell receptor signaling pathway (GO:0050855)3.94055764
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.93737767
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.93737767
25regulation of alpha-beta T cell proliferation (GO:0046640)3.90328759
26transcription from mitochondrial promoter (GO:0006390)3.85714870
27positive regulation of interleukin-4 production (GO:0032753)3.84982549
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84717800
29actin nucleation (GO:0045010)3.81856274
30lymphocyte migration (GO:0072676)3.80555825
31positive regulation of uterine smooth muscle contraction (GO:0070474)3.79471060
32glomerular visceral epithelial cell development (GO:0072015)3.73428033
33positive regulation of alpha-beta T cell proliferation (GO:0046641)3.72737100
34regulation of gamma-delta T cell differentiation (GO:0045586)3.70323139
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65050881
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.61305594
37lymphocyte chemotaxis (GO:0048247)3.55605177
38positive regulation of interleukin-2 production (GO:0032743)3.55228197
39mitochondrial respiratory chain complex assembly (GO:0033108)3.54660664
40negative thymic T cell selection (GO:0045060)3.51037691
41immunoglobulin mediated immune response (GO:0016064)3.50093076
42ribonucleoprotein complex disassembly (GO:0032988)3.48998567
43regulation of interleukin-2 biosynthetic process (GO:0045076)3.42419356
44mRNA modification (GO:0016556)3.36406486
45regulation of cAMP-mediated signaling (GO:0043949)3.35688685
46regulation of gamma-delta T cell activation (GO:0046643)3.32795359
47leukocyte tethering or rolling (GO:0050901)3.31200648
48regulation of DNA endoreduplication (GO:0032875)3.28158588
49signal complex assembly (GO:0007172)3.21892512
50glomerular epithelial cell development (GO:0072310)3.21890645
51protein complex biogenesis (GO:0070271)3.19883035
52regulation of defense response to virus by virus (GO:0050690)3.18350376
53protein K6-linked ubiquitination (GO:0085020)3.15502370
54thymic T cell selection (GO:0045061)3.08840091
55regulation of cellular extravasation (GO:0002691)3.07054149
56DNA dealkylation (GO:0035510)3.05244379
57B cell mediated immunity (GO:0019724)3.04584096
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.01178998
59response to interferon-alpha (GO:0035455)2.99451665
60positive regulation of T cell cytokine production (GO:0002726)2.98683341
61lactate metabolic process (GO:0006089)2.97620841
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95158245
63NIK/NF-kappaB signaling (GO:0038061)2.91867347
64T cell receptor signaling pathway (GO:0050852)2.91629563
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91552993
66response to interferon-beta (GO:0035456)2.90833563
67regulation of T cell mediated cytotoxicity (GO:0001914)2.89609584
68blood vessel maturation (GO:0001955)2.86923506
69T cell costimulation (GO:0031295)2.82413678
70parental behavior (GO:0060746)2.81566033
71glycosphingolipid biosynthetic process (GO:0006688)2.79753743
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.78849300
73lymphocyte costimulation (GO:0031294)2.78702253
74negative regulation of T cell apoptotic process (GO:0070233)2.78582670
75glomerular basement membrane development (GO:0032836)2.77934920
76L-serine metabolic process (GO:0006563)2.77750968
77positive regulation of calcium-mediated signaling (GO:0050850)2.77432704
78myeloid dendritic cell activation (GO:0001773)2.75570193
79otic vesicle formation (GO:0030916)2.75542226
80regulation of neuron projection regeneration (GO:0070570)2.74924745
81regulation of axon regeneration (GO:0048679)2.74924745
82Peyers patch development (GO:0048541)2.74719117
83mucosal-associated lymphoid tissue development (GO:0048537)2.74719117
84positive regulation of lamellipodium assembly (GO:0010592)2.74192118
85regulation of uterine smooth muscle contraction (GO:0070472)2.74102713
86regulation of execution phase of apoptosis (GO:1900117)2.73720356
87positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73573904
88antigen receptor-mediated signaling pathway (GO:0050851)2.71260212
89positive regulation of growth hormone secretion (GO:0060124)2.71068802
90positive regulation of DNA-dependent DNA replication (GO:2000105)2.68951537
91regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.66634363
92regulation of protein heterodimerization activity (GO:0043497)2.66518558
93heterochromatin organization (GO:0070828)2.66389559
94protein K11-linked deubiquitination (GO:0035871)2.66076058
95adenosine metabolic process (GO:0046085)2.65742188
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63820319
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.63820319
98membrane budding (GO:0006900)2.61653601
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59096006
100oocyte development (GO:0048599)2.59031885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.39357250
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30103308
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58091900
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.53120704
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06257333
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.90631055
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76438145
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64890829
9TAF15_26573619_Chip-Seq_HEK293_Human2.39382982
10MYB_26560356_Chip-Seq_TH2_Human2.37815174
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36663614
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34159424
13E2F7_22180533_ChIP-Seq_HELA_Human2.22273868
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.13512671
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10483090
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.09610328
17CIITA_25753668_ChIP-Seq_RAJI_Human2.08650311
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.04388390
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94616235
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92522967
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87956266
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.85466603
23GATA3_26560356_Chip-Seq_TH2_Human1.82901329
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.80935449
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80758046
26VDR_23849224_ChIP-Seq_CD4+_Human1.79604878
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79029677
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78474868
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75268754
30GATA3_27048872_Chip-Seq_THYMUS_Human1.74915719
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69534932
32MYB_26560356_Chip-Seq_TH1_Human1.62128616
33FUS_26573619_Chip-Seq_HEK293_Human1.60559308
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59193358
35ZNF274_21170338_ChIP-Seq_K562_Hela1.58462799
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.54495027
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51911310
38FOXP3_21729870_ChIP-Seq_TREG_Human1.51776904
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48248245
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47842816
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45316873
42GATA1_22025678_ChIP-Seq_K562_Human1.44104306
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.39737691
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38836443
45TP53_22573176_ChIP-Seq_HFKS_Human1.37842615
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37517402
47SCL_19346495_ChIP-Seq_HPC-7_Human1.36488365
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34091887
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.33430655
50OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30729491
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30451432
52P300_19829295_ChIP-Seq_ESCs_Human1.30349389
53ELK1_19687146_ChIP-ChIP_HELA_Human1.29480481
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26908691
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.25233830
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24345069
57AR_20517297_ChIP-Seq_VCAP_Human1.23432357
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21517929
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21040609
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20600743
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16963991
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16913012
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15570289
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14740538
65MYC_18940864_ChIP-ChIP_HL60_Human1.09934508
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09431843
67BCAT_22108803_ChIP-Seq_LS180_Human1.09328420
68ER_23166858_ChIP-Seq_MCF-7_Human1.07235541
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06955005
70EWS_26573619_Chip-Seq_HEK293_Human1.05885844
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05223365
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05154578
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04087874
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03620126
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03174993
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03112750
77RXR_22108803_ChIP-Seq_LS180_Human1.02789120
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00372699
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98292713
80GATA3_26560356_Chip-Seq_TH1_Human0.97675287
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97569397
82GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97461992
83MAF_26560356_Chip-Seq_TH1_Human0.95480353
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.95000011
85VDR_22108803_ChIP-Seq_LS180_Human0.94861702
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.94259143
87RBPJ_21746931_ChIP-Seq_IB4_Human0.93897886
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.93765949
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93765949
90PHF8_20622853_ChIP-Seq_HELA_Human0.93596214
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92307940
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.92118869
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91962952
94UTX_26944678_Chip-Seq_JUKART_Human0.91134835
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90639084
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90512540
97IRF8_27001747_Chip-Seq_BMDM_Mouse0.89958729
98SPI1_23547873_ChIP-Seq_NB4_Human0.89918817
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89599842
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88632546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.05642606
2MP0002102_abnormal_ear_morphology4.28672547
3MP0008057_abnormal_DNA_replication3.75240908
4MP0003880_abnormal_central_pattern3.29990573
5MP0001835_abnormal_antigen_presentation3.20213794
6MP0003045_fibrosis3.06137960
7MP0001529_abnormal_vocalization3.03617492
8MP0009785_altered_susceptibility_to2.92463720
9MP0005645_abnormal_hypothalamus_physiol2.88119380
10MP0003763_abnormal_thymus_physiology2.80453291
11MP0002166_altered_tumor_susceptibility2.73621517
12MP0003866_abnormal_defecation2.49270271
13MP0003787_abnormal_imprinting2.25064905
14MP0003195_calcinosis2.06966811
15MP0002909_abnormal_adrenal_gland1.90781004
16MP0001346_abnormal_lacrimal_gland1.89115842
17MP0001800_abnormal_humoral_immune1.86788522
18MP0005000_abnormal_immune_tolerance1.84603048
19MP0000685_abnormal_immune_system1.76461260
20MP0009333_abnormal_splenocyte_physiolog1.72098461
21MP0005025_abnormal_response_to1.67927131
22MP0002006_tumorigenesis1.66256109
23MP0006276_abnormal_autonomic_nervous1.62125109
24MP0002168_other_aberrant_phenotype1.60356072
25MP0010094_abnormal_chromosome_stability1.59769884
26MP0002405_respiratory_system_inflammati1.59007789
27MP0006035_abnormal_mitochondrial_morpho1.54324855
28MP0003786_premature_aging1.52772690
29MP0002723_abnormal_immune_serum1.50019510
30MP0005377_hearing/vestibular/ear_phenot1.48475297
31MP0003878_abnormal_ear_physiology1.48475297
32MP0005646_abnormal_pituitary_gland1.45122094
33MP0002420_abnormal_adaptive_immunity1.45027829
34MP0002127_abnormal_cardiovascular_syste1.42533760
35MP0002254_reproductive_system_inflammat1.42364293
36MP0008872_abnormal_physiological_respon1.42008047
37MP0002452_abnormal_antigen_presenting1.39298940
38MP0001819_abnormal_immune_cell1.38578917
39MP0005647_abnormal_sex_gland1.37708148
40MP0000372_irregular_coat_pigmentation1.35712494
41MP0005387_immune_system_phenotype1.34902099
42MP0001790_abnormal_immune_system1.34902099
43MP0005167_abnormal_blood-brain_barrier1.30649353
44MP0003724_increased_susceptibility_to1.29651165
45MP0002736_abnormal_nociception_after1.27205119
46MP0010386_abnormal_urinary_bladder1.26771079
47MP0005332_abnormal_amino_acid1.22951207
48MP0000566_synostosis1.21633235
49MP0000716_abnormal_immune_system1.19643075
50MP0001873_stomach_inflammation1.19439317
51MP0001905_abnormal_dopamine_level1.18892392
52MP0002163_abnormal_gland_morphology1.14983820
53MP0002693_abnormal_pancreas_physiology1.14551603
54MP0006082_CNS_inflammation1.12608369
55MP0008058_abnormal_DNA_repair1.11808647
56MP0002398_abnormal_bone_marrow1.10965230
57MP0005379_endocrine/exocrine_gland_phen1.08284161
58MP0000639_abnormal_adrenal_gland1.06145417
59MP0006072_abnormal_retinal_apoptosis1.05855661
60MP0005266_abnormal_metabolism0.98399690
61MP0006036_abnormal_mitochondrial_physio0.97718172
62MP0010155_abnormal_intestine_physiology0.94363057
63MP0000427_abnormal_hair_cycle0.92824364
64MP0005166_decreased_susceptibility_to0.92738917
65MP0005551_abnormal_eye_electrophysiolog0.88590326
66MP0001501_abnormal_sleep_pattern0.86747518
67MP0000631_abnormal_neuroendocrine_gland0.86279407
68MP0003303_peritoneal_inflammation0.85587317
69MP0002429_abnormal_blood_cell0.83836596
70MP0001764_abnormal_homeostasis0.83036136
71MP0000230_abnormal_systemic_arterial0.82764699
72MP0001845_abnormal_inflammatory_respons0.82296258
73MP0008873_increased_physiological_sensi0.82289660
74MP0002019_abnormal_tumor_incidence0.81541837
75MP0003638_abnormal_response/metabolism_0.80324891
76MP0003123_paternal_imprinting0.80273297
77MP0002148_abnormal_hypersensitivity_rea0.79304040
78MP0000703_abnormal_thymus_morphology0.76087927
79MP0004924_abnormal_behavior0.75469771
80MP0005386_behavior/neurological_phenoty0.75469771
81MP0000689_abnormal_spleen_morphology0.74780314
82MP0003959_abnormal_lean_body0.73170646
83MP0004134_abnormal_chest_morphology0.72086346
84MP0003077_abnormal_cell_cycle0.70651819
85MP0000490_abnormal_crypts_of0.69351165
86MP0004215_abnormal_myocardial_fiber0.68958531
87MP0005253_abnormal_eye_physiology0.68866145
88MP0010368_abnormal_lymphatic_system0.68758979
89MP0002419_abnormal_innate_immunity0.68583844
90MP0006138_congestive_heart_failure0.68569676
91MP0003448_altered_tumor_morphology0.68502550
92MP0008469_abnormal_protein_level0.68152870
93MP0002078_abnormal_glucose_homeostasis0.67964713
94MP0009643_abnormal_urine_homeostasis0.67839717
95MP0003111_abnormal_nucleus_morphology0.67002356
96MP0002722_abnormal_immune_system0.65661451
97MP0002138_abnormal_hepatobiliary_system0.65610772
98MP0000538_abnormal_urinary_bladder0.65554452
99MP0001440_abnormal_grooming_behavior0.65254339
100MP0002653_abnormal_ependyma_morphology0.65004814

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.99225721
2Hypoproteinemia (HP:0003075)5.44312880
3Aplastic anemia (HP:0001915)5.31556526
4Volvulus (HP:0002580)3.95843959
5Recurrent corneal erosions (HP:0000495)3.83767694
6Severe combined immunodeficiency (HP:0004430)3.76375329
7Hepatocellular necrosis (HP:0001404)3.73982037
8Abnormality of the labia minora (HP:0012880)3.67697944
9Abnormality of alanine metabolism (HP:0010916)3.54601304
10Hyperalaninemia (HP:0003348)3.54601304
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.54601304
12T lymphocytopenia (HP:0005403)3.52832387
13Abnormal drinking behavior (HP:0030082)3.49308551
14Polydipsia (HP:0001959)3.49308551
15Renal Fanconi syndrome (HP:0001994)3.37152921
16Abnormality of T cell number (HP:0011839)3.23142205
17Spastic paraparesis (HP:0002313)3.23106988
18Abnormality of serum amino acid levels (HP:0003112)3.17972927
19Generalized aminoaciduria (HP:0002909)3.16508918
20Sensory axonal neuropathy (HP:0003390)3.10181749
21Tubular atrophy (HP:0000092)3.07446809
22Hepatic necrosis (HP:0002605)3.07091537
23Abnormal albumin level (HP:0012116)3.04268559
24Hypoalbuminemia (HP:0003073)3.04268559
25Combined immunodeficiency (HP:0005387)3.03157213
26Thyroiditis (HP:0100646)2.92145428
27Decreased lacrimation (HP:0000633)2.87637556
28Panhypogammaglobulinemia (HP:0003139)2.84824723
29Abnormal mitochondria in muscle tissue (HP:0008316)2.84084436
30IgG deficiency (HP:0004315)2.80385722
31Stomach cancer (HP:0012126)2.71887284
32IgM deficiency (HP:0002850)2.71095552
33Mitochondrial inheritance (HP:0001427)2.70919565
34Hypoplasia of the thymus (HP:0000778)2.70918802
35Increased intramyocellular lipid droplets (HP:0012240)2.68722932
36Increased CSF lactate (HP:0002490)2.65039797
37Broad alveolar ridges (HP:0000187)2.53448479
38Chronic otitis media (HP:0000389)2.52446786
39Large earlobe (HP:0009748)2.43288408
40Increased serum lactate (HP:0002151)2.38195856
41Polyuria (HP:0000103)2.36440242
42Abnormality of B cell number (HP:0010975)2.34849624
43Elevated erythrocyte sedimentation rate (HP:0003565)2.33467119
44Mild short stature (HP:0003502)2.33392844
45B lymphocytopenia (HP:0010976)2.31858784
46Abnormality of the renal collecting system (HP:0004742)2.30859240
47Mesangial abnormality (HP:0001966)2.30442431
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27367723
49Acute necrotizing encephalopathy (HP:0006965)2.27344514
50Recurrent viral infections (HP:0004429)2.24911448
51Duplicated collecting system (HP:0000081)2.23021861
52Pigmentary retinal degeneration (HP:0001146)2.22185273
53Alacrima (HP:0000522)2.21133240
54Chronic diarrhea (HP:0002028)2.19051673
55Esophageal atresia (HP:0002032)2.17254395
56Increased muscle lipid content (HP:0009058)2.16395147
57Progressive macrocephaly (HP:0004481)2.16317286
58Recurrent cutaneous fungal infections (HP:0011370)2.13176859
59Chronic mucocutaneous candidiasis (HP:0002728)2.13176859
60Slow saccadic eye movements (HP:0000514)2.01827074
61Agammaglobulinemia (HP:0004432)2.01343877
62Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97264700
63Lactic acidosis (HP:0003128)1.96112268
64Gastrointestinal atresia (HP:0002589)1.94796149
65Hypoplastic labia majora (HP:0000059)1.94680672
66Pancytopenia (HP:0001876)1.93981871
67Abnormality of T cells (HP:0002843)1.93314651
68Prostate neoplasm (HP:0100787)1.92932884
69Abnormal urine output (HP:0012590)1.92833857
70Lymphoma (HP:0002665)1.92408760
71Palpebral edema (HP:0100540)1.90896073
72Trigonocephaly (HP:0000243)1.90823453
73Abnormality of renal resorption (HP:0011038)1.90759771
74Acute encephalopathy (HP:0006846)1.90495663
75Exertional dyspnea (HP:0002875)1.86466037
76Abnormality of eosinophils (HP:0001879)1.85606064
77Large for gestational age (HP:0001520)1.84970201
78Recurrent otitis media (HP:0000403)1.84213750
79Abnormality of midbrain morphology (HP:0002418)1.83445555
80Molar tooth sign on MRI (HP:0002419)1.83445555
81Recurrent bronchitis (HP:0002837)1.83081523
82Lymphopenia (HP:0001888)1.77343686
83Spontaneous hematomas (HP:0007420)1.75714649
84Increased serum pyruvate (HP:0003542)1.75333575
85Abnormality of the labia majora (HP:0012881)1.74983859
86Amyotrophic lateral sclerosis (HP:0007354)1.74738138
87Hypokalemia (HP:0002900)1.73873999
88CNS demyelination (HP:0007305)1.73494013
89Ragged-red muscle fibers (HP:0003200)1.72823822
90Dry hair (HP:0011359)1.72494924
91Renal agenesis (HP:0000104)1.72334459
92Ureteral obstruction (HP:0006000)1.71809358
93Reduced subcutaneous adipose tissue (HP:0003758)1.70961108
94Male infertility (HP:0003251)1.70682566
95Pancreatic islet-cell hyperplasia (HP:0004510)1.70214346
96Abnormality of the prostate (HP:0008775)1.70107516
97Sensorimotor neuropathy (HP:0007141)1.69543183
98Microglossia (HP:0000171)1.69343867
99Increased hepatocellular lipid droplets (HP:0006565)1.68493294
100Paraparesis (HP:0002385)1.67429177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.70506930
2EPHA45.52804764
3KDR3.68326873
4SCYL23.63885506
5MAP4K13.50533428
6EIF2AK33.46109107
7TEC3.16331486
8TESK22.51001031
9ZAK2.46202111
10NEK12.45540576
11MAPKAPK32.12591148
12GRK12.09025728
13FGFR22.00457140
14BCKDK1.91785793
15NEK91.63601738
16ITK1.62461359
17FRK1.47019948
18SIK21.46515958
19EIF2AK11.36661985
20CAMK1G1.34354723
21TAOK31.34178616
22SYK1.29599707
23MAP3K121.24208256
24CLK11.20868966
25ADRBK21.14233843
26IRAK41.07105254
27WNK31.06711210
28BMPR1B1.05687911
29DAPK11.05507733
30CAMK1D1.03981510
31ERBB30.99599681
32BTK0.99225103
33IKBKE0.98620607
34MAP3K100.97494247
35PRKCQ0.96849724
36NEK20.95998223
37PLK40.92822556
38TLK10.91452065
39PASK0.88620562
40PNCK0.87912151
41CSK0.82769563
42BMPR20.81438384
43TESK10.79349195
44GRK60.78203774
45CSF1R0.77098464
46NME10.75416023
47RIPK40.74174338
48FES0.68017557
49TGFBR10.67854266
50CCNB10.63602580
51ATR0.61512119
52MAP3K40.60705184
53CHEK20.59298132
54MYLK0.59066521
55PINK10.57339590
56MAP3K50.56929740
57IKBKB0.56625829
58VRK10.56160033
59TRPM70.56154686
60VRK20.55821308
61CDC70.53948595
62LYN0.52986556
63STK160.52717922
64PIM20.52297754
65ATM0.50605096
66PLK10.50073415
67LIMK10.48296486
68LCK0.46769232
69KIT0.45458888
70MAP3K140.44500741
71TNK20.44257802
72INSRR0.44121326
73BLK0.43264396
74TGFBR20.41876291
75CAMK10.39065819
76MAPK130.38476311
77PRKD30.37959636
78MAPK110.35762276
79HCK0.34714827
80ABL10.34628108
81FGFR10.34015234
82TXK0.32846153
83CDK30.31893204
84ROCK10.31316628
85INSR0.31181494
86PTK2B0.27488111
87IGF1R0.25680948
88EGFR0.25236109
89CSNK2A20.25230780
90MAPK40.23904063
91CSNK1G10.22969314
92RPS6KA50.21397229
93MAPKAPK20.20624185
94STK100.19878572
95STK240.19336062
96PRKCB0.19011578
97PKN10.18401505
98TBK10.18173378
99PRKCA0.17828644
100STK38L0.17725245

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.38015109
2Selenocompound metabolism_Homo sapiens_hsa004503.66643970
3Proteasome_Homo sapiens_hsa030503.13976144
4Allograft rejection_Homo sapiens_hsa053302.99708476
5Graft-versus-host disease_Homo sapiens_hsa053322.91933914
6Autoimmune thyroid disease_Homo sapiens_hsa053202.84900911
7Type I diabetes mellitus_Homo sapiens_hsa049402.81448048
8Antigen processing and presentation_Homo sapiens_hsa046122.76530807
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35332073
10Asthma_Homo sapiens_hsa053102.30346801
11Oxidative phosphorylation_Homo sapiens_hsa001902.28005455
12T cell receptor signaling pathway_Homo sapiens_hsa046601.89542895
13Parkinsons disease_Homo sapiens_hsa050121.88347063
14Viral myocarditis_Homo sapiens_hsa054161.85801233
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83274672
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72213548
17Hematopoietic cell lineage_Homo sapiens_hsa046401.69951940
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68858757
19Homologous recombination_Homo sapiens_hsa034401.59055418
20Propanoate metabolism_Homo sapiens_hsa006401.45612067
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.45197642
22Fanconi anemia pathway_Homo sapiens_hsa034601.40364214
23Steroid biosynthesis_Homo sapiens_hsa001001.38199954
24DNA replication_Homo sapiens_hsa030301.35420845
25Mismatch repair_Homo sapiens_hsa034301.28188245
26Protein export_Homo sapiens_hsa030601.28101403
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25383876
28Herpes simplex infection_Homo sapiens_hsa051681.23683468
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21290808
30Rheumatoid arthritis_Homo sapiens_hsa053231.14825065
31Systemic lupus erythematosus_Homo sapiens_hsa053221.13873978
32Non-homologous end-joining_Homo sapiens_hsa034501.13624748
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13191248
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11887660
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10599774
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10412638
37Alzheimers disease_Homo sapiens_hsa050101.09581966
38Huntingtons disease_Homo sapiens_hsa050161.08541745
39Measles_Homo sapiens_hsa051621.07618662
40Ribosome_Homo sapiens_hsa030101.06990469
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00631496
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00323939
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97137275
44Regulation of autophagy_Homo sapiens_hsa041400.96755305
45Leishmaniasis_Homo sapiens_hsa051400.96035434
46Malaria_Homo sapiens_hsa051440.91270465
47Staphylococcus aureus infection_Homo sapiens_hsa051500.83919263
48Pyrimidine metabolism_Homo sapiens_hsa002400.83355786
49RNA degradation_Homo sapiens_hsa030180.83047489
50Nucleotide excision repair_Homo sapiens_hsa034200.80038868
51RNA polymerase_Homo sapiens_hsa030200.79760371
52Taste transduction_Homo sapiens_hsa047420.79340917
53One carbon pool by folate_Homo sapiens_hsa006700.74520550
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74420824
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71353360
56Cardiac muscle contraction_Homo sapiens_hsa042600.68799300
57Base excision repair_Homo sapiens_hsa034100.67663829
58Butanoate metabolism_Homo sapiens_hsa006500.64619353
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63977542
60Purine metabolism_Homo sapiens_hsa002300.58672751
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57018361
62Pyruvate metabolism_Homo sapiens_hsa006200.55270321
63Salivary secretion_Homo sapiens_hsa049700.55114892
64Shigellosis_Homo sapiens_hsa051310.54814739
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.53767042
66African trypanosomiasis_Homo sapiens_hsa051430.53336983
67Basal transcription factors_Homo sapiens_hsa030220.52857553
68Peroxisome_Homo sapiens_hsa041460.52555067
69Influenza A_Homo sapiens_hsa051640.51055697
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49233276
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48695844
72Phototransduction_Homo sapiens_hsa047440.48015028
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47161370
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46596051
75HTLV-I infection_Homo sapiens_hsa051660.45863617
76Cell cycle_Homo sapiens_hsa041100.43440802
77RNA transport_Homo sapiens_hsa030130.41235808
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40982822
79Epstein-Barr virus infection_Homo sapiens_hsa051690.40763252
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.36701171
81Legionellosis_Homo sapiens_hsa051340.34128340
82Carbon metabolism_Homo sapiens_hsa012000.34094672
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33208107
84Spliceosome_Homo sapiens_hsa030400.33128255
85Sulfur metabolism_Homo sapiens_hsa009200.33018609
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28463266
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27936368
88Chemical carcinogenesis_Homo sapiens_hsa052040.26748008
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26717820
90mRNA surveillance pathway_Homo sapiens_hsa030150.26592123
91Phagosome_Homo sapiens_hsa041450.26256294
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25352855
93Retinol metabolism_Homo sapiens_hsa008300.25297896
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25145712
95Olfactory transduction_Homo sapiens_hsa047400.23788451
96Toxoplasmosis_Homo sapiens_hsa051450.21382680
97Metabolic pathways_Homo sapiens_hsa011000.20392300
98Salmonella infection_Homo sapiens_hsa051320.19781741
99Apoptosis_Homo sapiens_hsa042100.19627985
100Alcoholism_Homo sapiens_hsa050340.18315288

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