CASK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)7.00651732
2postsynaptic membrane organization (GO:0001941)6.46949459
3presynaptic membrane organization (GO:0097090)6.20571758
4neuron cell-cell adhesion (GO:0007158)5.79106177
5short-term memory (GO:0007614)4.62698201
6vocalization behavior (GO:0071625)4.38220519
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33916128
8protein localization to synapse (GO:0035418)4.22339365
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12762698
10positive regulation of synapse assembly (GO:0051965)3.99821165
11neurotransmitter-gated ion channel clustering (GO:0072578)3.96216338
12neuronal action potential propagation (GO:0019227)3.75579249
13cerebral cortex radially oriented cell migration (GO:0021799)3.74678639
14startle response (GO:0001964)3.63247138
15neuron recognition (GO:0008038)3.55677668
16regulation of glutamate receptor signaling pathway (GO:1900449)3.50120929
17limb bud formation (GO:0060174)3.46984263
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46751760
19membrane assembly (GO:0071709)3.44341296
20regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43910267
21nucleobase catabolic process (GO:0046113)3.41402300
22regulation of synapse assembly (GO:0051963)3.33848965
23righting reflex (GO:0060013)3.31804733
24facial nerve structural organization (GO:0021612)3.29690596
25paraxial mesoderm development (GO:0048339)3.27898188
26retina layer formation (GO:0010842)3.24200601
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.23445160
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22650024
29synapse assembly (GO:0007416)3.21418587
30apical protein localization (GO:0045176)3.20786987
31locomotory exploration behavior (GO:0035641)3.19598448
32cranial nerve structural organization (GO:0021604)3.15442359
33central nervous system myelination (GO:0022010)3.14952833
34axon ensheathment in central nervous system (GO:0032291)3.14952833
35cell migration in hindbrain (GO:0021535)3.09148982
36glutamate receptor signaling pathway (GO:0007215)3.06155943
37exploration behavior (GO:0035640)3.05809925
38axonal fasciculation (GO:0007413)3.04241784
39pyrimidine nucleobase catabolic process (GO:0006208)3.03454508
40regulation of pigment cell differentiation (GO:0050932)3.01265922
41axon extension (GO:0048675)2.98313665
42neuron projection extension involved in neuron projection guidance (GO:1902284)2.95728333
43axon extension involved in axon guidance (GO:0048846)2.95728333
44central nervous system projection neuron axonogenesis (GO:0021952)2.95513462
45positive regulation of protein kinase C signaling (GO:0090037)2.94483989
46regulation of respiratory system process (GO:0044065)2.93971127
47mechanosensory behavior (GO:0007638)2.93641327
48metanephric tubule development (GO:0072170)2.87633775
49metanephric nephron tubule development (GO:0072234)2.87633775
50sympathetic nervous system development (GO:0048485)2.87587810
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87364247
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85310916
53dendritic spine morphogenesis (GO:0060997)2.84166414
54lateral sprouting from an epithelium (GO:0060601)2.83214063
55synaptic transmission, glutamatergic (GO:0035249)2.82095362
56central nervous system neuron axonogenesis (GO:0021955)2.81613294
57positive regulation of membrane potential (GO:0045838)2.80519495
58regulation of protein kinase A signaling (GO:0010738)2.79236874
59neuron-neuron synaptic transmission (GO:0007270)2.78830487
60positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78759679
61regulation of synaptic vesicle exocytosis (GO:2000300)2.78410995
62embryonic foregut morphogenesis (GO:0048617)2.78030930
63regulation of timing of cell differentiation (GO:0048505)2.77789656
64transmission of nerve impulse (GO:0019226)2.77685523
65synaptic vesicle exocytosis (GO:0016079)2.76751369
66negative regulation of neurotransmitter transport (GO:0051589)2.76269207
67cerebellar granule cell differentiation (GO:0021707)2.75920463
68negative regulation of execution phase of apoptosis (GO:1900118)2.75821066
69regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75805117
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75765574
71establishment of nucleus localization (GO:0040023)2.74634986
72dendrite morphogenesis (GO:0048813)2.74630886
73retinal ganglion cell axon guidance (GO:0031290)2.74554924
74negative chemotaxis (GO:0050919)2.73181265
75eye photoreceptor cell differentiation (GO:0001754)2.71663265
76photoreceptor cell differentiation (GO:0046530)2.71663265
77ephrin receptor signaling pathway (GO:0048013)2.71312314
78negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.69880506
79innervation (GO:0060384)2.69098501
80establishment of tissue polarity (GO:0007164)2.69064823
81establishment of planar polarity (GO:0001736)2.69064823
82oligodendrocyte differentiation (GO:0048709)2.68631719
83dendrite development (GO:0016358)2.67711302
84negative regulation of axon guidance (GO:1902668)2.67405286
85regulation of respiratory gaseous exchange (GO:0043576)2.66949026
86regulation of synapse organization (GO:0050807)2.66900516
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.66572893
88negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.66370061
89dermatan sulfate biosynthetic process (GO:0030208)2.66327709
90neuron projection extension (GO:1990138)2.64989645
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.62995132
92regulation of postsynaptic membrane potential (GO:0060078)2.62334824
93anatomical structure arrangement (GO:0048532)2.61090062
94regulation of axon extension involved in axon guidance (GO:0048841)2.60938545
95regulation of synaptic transmission, GABAergic (GO:0032228)2.60892181
96auditory behavior (GO:0031223)2.60707407
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59913175
98pattern specification involved in kidney development (GO:0061004)2.59889227
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59364816
100cranial nerve morphogenesis (GO:0021602)2.58395670
101negative regulation of axon extension involved in axon guidance (GO:0048843)2.57837766
102layer formation in cerebral cortex (GO:0021819)2.56873129
103positive regulation of dendritic spine development (GO:0060999)2.56390305
104regulation of neuron migration (GO:2001222)2.55961703
105negative regulation of axon extension (GO:0030517)2.55293979
106mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55195797
107mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55195797
108nonmotile primary cilium assembly (GO:0035058)2.55172130
109long-chain fatty acid biosynthetic process (GO:0042759)2.54731757
110cerebral cortex cell migration (GO:0021795)2.54368829
111camera-type eye morphogenesis (GO:0048593)2.54215567
112metanephric nephron epithelium development (GO:0072243)2.53106902
113metanephric epithelium development (GO:0072207)2.52380935
114negative regulation of dendrite morphogenesis (GO:0050774)2.52202364
115glutamate secretion (GO:0014047)2.51559410
116asymmetric protein localization (GO:0008105)2.51322498
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51147151
118negative regulation of neurotransmitter secretion (GO:0046929)2.49704171
119dermatan sulfate metabolic process (GO:0030205)2.49356385
120regulation of axon guidance (GO:1902667)2.49041126
121artery development (GO:0060840)2.48630404
122long-term synaptic potentiation (GO:0060291)2.48458660
123dorsal/ventral axis specification (GO:0009950)2.48245325
124notochord development (GO:0030903)2.47902741
125regulation of dendritic spine development (GO:0060998)2.47720945
126* negative regulation of keratinocyte proliferation (GO:0010839)2.45581558
127establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.45345381
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42313642
129hippo signaling (GO:0035329)2.40691100
130convergent extension (GO:0060026)2.39873357
131kidney morphogenesis (GO:0060993)2.36971625
132spinal cord development (GO:0021510)2.33396281
133gastrulation with mouth forming second (GO:0001702)2.33311197
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.33206473
135developmental cell growth (GO:0048588)2.32341831
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31972679
137ectodermal placode formation (GO:0060788)2.30803646
138ganglion development (GO:0061548)2.27019121
139pre-miRNA processing (GO:0031054)2.26412176
140regulation of transforming growth factor beta2 production (GO:0032909)2.26356108
141anterior/posterior axis specification, embryo (GO:0008595)2.25838804
142neuron migration (GO:0001764)2.25233932
143mating behavior (GO:0007617)2.24662362
144cell surface receptor signaling pathway involved in heart development (GO:0061311)2.22357544
145body morphogenesis (GO:0010171)2.21604520
146lens morphogenesis in camera-type eye (GO:0002089)2.21520095
147bundle of His cell to Purkinje myocyte communication (GO:0086069)2.19265334
148hemidesmosome assembly (GO:0031581)2.18461693
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.17935016
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.17795636
151olfactory bulb development (GO:0021772)2.15280773
152neuronal stem cell maintenance (GO:0097150)2.14690579
153lung-associated mesenchyme development (GO:0060484)2.13194970
154regulation of establishment of planar polarity (GO:0090175)2.12700457
155otic vesicle formation (GO:0030916)2.11912508
156cerebral cortex development (GO:0021987)2.11829482
157establishment of mitochondrion localization (GO:0051654)2.11006025
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.09710319
159genitalia morphogenesis (GO:0035112)2.08426230
160appendage development (GO:0048736)2.06988271
161limb development (GO:0060173)2.06988271
162homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.05509241
163suckling behavior (GO:0001967)2.05295106
164morphogenesis of an epithelial sheet (GO:0002011)2.05030989
165embryonic body morphogenesis (GO:0010172)2.05021959
166glomerulus development (GO:0032835)2.04890013
167positive regulation of catenin import into nucleus (GO:0035413)2.04883517
168developmental growth involved in morphogenesis (GO:0060560)2.04865966
169establishment or maintenance of apical/basal cell polarity (GO:0035088)2.04369698
170establishment or maintenance of bipolar cell polarity (GO:0061245)2.04369698
171adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.03410876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71756923
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.28709187
3GBX2_23144817_ChIP-Seq_PC3_Human3.96008860
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07272977
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86393666
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.81052287
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78387152
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.73771622
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67677074
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60596659
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60596659
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55602857
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49958681
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46720112
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.37290513
16TAF15_26573619_Chip-Seq_HEK293_Human2.35453592
17AR_21572438_ChIP-Seq_LNCaP_Human2.34694000
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34077226
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.29566623
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19050928
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17255308
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.12845626
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08483788
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05416807
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04555911
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.04210039
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00100357
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96851044
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96747803
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94576768
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92584004
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91281022
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81385133
34IGF1R_20145208_ChIP-Seq_DFB_Human1.80679601
35RNF2_27304074_Chip-Seq_NSC_Mouse1.78836334
36P300_19829295_ChIP-Seq_ESCs_Human1.76605715
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75056685
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.74541061
39* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61519716
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.60472654
41* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58437128
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57050141
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55555437
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.54498683
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54454739
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.54117215
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.50958190
48REST_21632747_ChIP-Seq_MESCs_Mouse1.50802493
49FUS_26573619_Chip-Seq_HEK293_Human1.49994756
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49215093
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49169144
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.47382109
53ER_23166858_ChIP-Seq_MCF-7_Human1.46527820
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45283532
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44909275
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.44847682
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42636041
58VDR_22108803_ChIP-Seq_LS180_Human1.42425523
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.41537396
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.41166914
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40959457
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40663264
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39440208
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36686584
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35805127
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34668146
67TP53_18474530_ChIP-ChIP_U2OS_Human1.33920938
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.33213303
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.33031067
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.32939766
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30956573
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28341590
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.25985884
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25980115
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25768397
76STAT3_23295773_ChIP-Seq_U87_Human1.23685161
77DROSHA_22980978_ChIP-Seq_HELA_Human1.23563029
78AR_25329375_ChIP-Seq_VCAP_Human1.23325202
79* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23234564
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23044727
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21459365
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21384040
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.21081586
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21054489
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21035072
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.19399617
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.18916137
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18838200
89ZNF274_21170338_ChIP-Seq_K562_Hela1.18629933
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.16345231
91P53_22387025_ChIP-Seq_ESCs_Mouse1.15851968
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.15047010
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14592724
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14545705
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13551790
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.13456538
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13123211
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13123211
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12424774
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12081036
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11940909
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11839977
103AHR_22903824_ChIP-Seq_MCF-7_Human1.11648689
104TP53_16413492_ChIP-PET_HCT116_Human1.11252938
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.10831647
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10646675
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09068145
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08527837
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08178184
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07880624
111* TCF4_23295773_ChIP-Seq_U87_Human1.07444634
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.06380055
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.06357398
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06103137
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.05519165
116TRIM28_21343339_ChIP-Seq_HEK293_Human1.05490674
117KDM2B_26808549_Chip-Seq_REH_Human1.04731985
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04433779
119* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04407073
120CDX2_20551321_ChIP-Seq_CACO-2_Human1.04279529
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04032092
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03465500
123P300_18555785_Chip-Seq_ESCs_Mouse1.03354664
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.02390484
125* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02240333
126SOX9_26525672_Chip-Seq_HEART_Mouse1.01742723
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01711087
128EWS_26573619_Chip-Seq_HEK293_Human1.01368826
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01229751
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01229751
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.99715691
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.99576782
133* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98704916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.43234186
2MP0001188_hyperpigmentation4.30842969
3MP0003880_abnormal_central_pattern4.28188849
4MP0005409_darkened_coat_color3.52915846
5MP0009379_abnormal_foot_pigmentation2.70402447
6MP0001968_abnormal_touch/_nociception2.52173992
7MP0004859_abnormal_synaptic_plasticity2.47055215
8MP0004270_analgesia2.38569837
9MP0000537_abnormal_urethra_morphology2.31303233
10MP0000778_abnormal_nervous_system2.27780194
11* MP0003635_abnormal_synaptic_transmissio2.23122426
12MP0001486_abnormal_startle_reflex2.22000582
13MP0004381_abnormal_hair_follicle2.14008464
14MP0005171_absent_coat_pigmentation2.05727142
15MP0009745_abnormal_behavioral_response2.04614001
16MP0009046_muscle_twitch2.03602128
17MP0003890_abnormal_embryonic-extraembry2.00761383
18MP0005423_abnormal_somatic_nervous1.98572348
19MP0004742_abnormal_vestibular_system1.96083976
20MP0002734_abnormal_mechanical_nocicepti1.95637255
21MP0002735_abnormal_chemical_nociception1.93245926
22MP0006276_abnormal_autonomic_nervous1.86848908
23MP0002064_seizures1.85040502
24MP0002272_abnormal_nervous_system1.82089248
25MP0006292_abnormal_olfactory_placode1.80888469
26MP0002063_abnormal_learning/memory/cond1.79188396
27MP0002067_abnormal_sensory_capabilities1.78093976
28MP0002184_abnormal_innervation1.76792632
29MP0000015_abnormal_ear_pigmentation1.72413570
30MP0000566_synostosis1.71676081
31MP0002572_abnormal_emotion/affect_behav1.71261238
32MP0009250_abnormal_appendicular_skeleto1.64877527
33MP0005187_abnormal_penis_morphology1.62220472
34MP0002736_abnormal_nociception_after1.60739644
35MP0002697_abnormal_eye_size1.60472773
36MP0003119_abnormal_digestive_system1.57029637
37MP0009053_abnormal_anal_canal1.56909133
38MP0002557_abnormal_social/conspecific_i1.55863640
39MP0004142_abnormal_muscle_tone1.55175364
40MP0010030_abnormal_orbit_morphology1.52346838
41MP0004272_abnormal_basement_membrane1.51459490
42MP0003283_abnormal_digestive_organ1.50476764
43MP0003938_abnormal_ear_development1.50293292
44MP0001970_abnormal_pain_threshold1.46393068
45MP0002102_abnormal_ear_morphology1.44392081
46MP0002822_catalepsy1.44136112
47MP0000631_abnormal_neuroendocrine_gland1.43512591
48MP0010234_abnormal_vibrissa_follicle1.42134852
49MP0000049_abnormal_middle_ear1.41866740
50MP0003385_abnormal_body_wall1.41866060
51MP0002751_abnormal_autonomic_nervous1.41794440
52MP0003121_genomic_imprinting1.38590617
53MP0002249_abnormal_larynx_morphology1.36855948
54MP0003941_abnormal_skin_development1.35397900
55MP0005646_abnormal_pituitary_gland1.34499274
56MP0002733_abnormal_thermal_nociception1.30535637
57MP0000955_abnormal_spinal_cord1.29953515
58MP0001286_abnormal_eye_development1.29530699
59MP0005645_abnormal_hypothalamus_physiol1.28855165
60MP0000462_abnormal_digestive_system1.28096965
61MP0002177_abnormal_outer_ear1.27775828
62MP0002882_abnormal_neuron_morphology1.25888824
63MP0000026_abnormal_inner_ear1.25228724
64* MP0003935_abnormal_craniofacial_develop1.22051699
65MP0003122_maternal_imprinting1.20474024
66MP0001299_abnormal_eye_distance/1.20169674
67MP0003787_abnormal_imprinting1.19640638
68MP0001984_abnormal_olfaction1.18224774
69MP0003123_paternal_imprinting1.17516651
70MP0000428_abnormal_craniofacial_morphol1.16998511
71MP0002752_abnormal_somatic_nervous1.16293049
72MP0000569_abnormal_digit_pigmentation1.16043187
73MP0010678_abnormal_skin_adnexa1.15872135
74MP0005174_abnormal_tail_pigmentation1.14591959
75MP0001293_anophthalmia1.14510990
76MP0001963_abnormal_hearing_physiology1.14317631
77MP0001177_atelectasis1.13641182
78MP0005551_abnormal_eye_electrophysiolog1.11915812
79MP0002084_abnormal_developmental_patter1.09440810
80MP0000647_abnormal_sebaceous_gland1.07779852
81MP0001440_abnormal_grooming_behavior1.06969803
82MP0003315_abnormal_perineum_morphology1.06725571
83MP0008569_lethality_at_weaning1.06056935
84MP0002234_abnormal_pharynx_morphology1.04725002
85MP0003937_abnormal_limbs/digits/tail_de1.02196092
86MP0000383_abnormal_hair_follicle1.01410245
87MP0001905_abnormal_dopamine_level1.01239423
88MP0002092_abnormal_eye_morphology1.00761402
89MP0002233_abnormal_nose_morphology0.99593993
90MP0008789_abnormal_olfactory_epithelium0.99368968
91MP0002909_abnormal_adrenal_gland0.99358894
92MP0009780_abnormal_chondrocyte_physiolo0.98538470
93* MP0002081_perinatal_lethality0.97989581
94MP0010352_gastrointestinal_tract_polyps0.97322985
95MP0005503_abnormal_tendon_morphology0.96865910
96MP0003942_abnormal_urinary_system0.96530124
97* MP0000432_abnormal_head_morphology0.96323023
98MP0001529_abnormal_vocalization0.96200886
99MP0004133_heterotaxia0.96181261
100MP0003115_abnormal_respiratory_system0.95510642
101MP0002152_abnormal_brain_morphology0.95241068
102MP0004858_abnormal_nervous_system0.94035885
103MP0004885_abnormal_endolymph0.93528567
104MP0000534_abnormal_ureter_morphology0.92780612
105MP0001849_ear_inflammation0.92710045
106MP0002938_white_spotting0.92663239
107MP0004264_abnormal_extraembryonic_tissu0.91907011
108MP0002876_abnormal_thyroid_physiology0.91394688
109* MP0002111_abnormal_tail_morphology0.90969073
110MP0001502_abnormal_circadian_rhythm0.90193699
111* MP0002066_abnormal_motor_capabilities/c0.90137607
112MP0001501_abnormal_sleep_pattern0.89997694
113MP0002085_abnormal_embryonic_tissue0.89607631
114MP0005499_abnormal_olfactory_system0.89562847
115MP0005394_taste/olfaction_phenotype0.89562847
116MP0005386_behavior/neurological_phenoty0.89075948
117MP0004924_abnormal_behavior0.89075948
118MP0009703_decreased_birth_body0.88591526
119MP0000920_abnormal_myelination0.86720892
120MP0001485_abnormal_pinna_reflex0.86490628
121* MP0003755_abnormal_palate_morphology0.86178882
122MP0000762_abnormal_tongue_morphology0.85897344
123MP0000579_abnormal_nail_morphology0.85820494
124MP0002098_abnormal_vibrissa_morphology0.85458936
125MP0005257_abnormal_intraocular_pressure0.85076593
126MP0000427_abnormal_hair_cycle0.84525639
127MP0005367_renal/urinary_system_phenotyp0.83697051
128MP0000516_abnormal_urinary_system0.83697051
129* MP0004811_abnormal_neuron_physiology0.83156368
130MP0003011_delayed_dark_adaptation0.83057269
131MP0005248_abnormal_Harderian_gland0.81447574
132MP0001346_abnormal_lacrimal_gland0.81169853
133MP0003705_abnormal_hypodermis_morpholog0.81023301
134MP0000467_abnormal_esophagus_morphology0.80171684
135MP0002282_abnormal_trachea_morphology0.78773791
136MP0004145_abnormal_muscle_electrophysio0.78576671
137MP0003861_abnormal_nervous_system0.77248016
138MP0001986_abnormal_taste_sensitivity0.76562005
139MP0006072_abnormal_retinal_apoptosis0.75680115
140* MP0002116_abnormal_craniofacial_bone0.74314137
141MP0001664_abnormal_digestion0.73644878
142MP0003634_abnormal_glial_cell0.73388297

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.00505012
2Obstructive sleep apnea (HP:0002870)3.75605797
3Febrile seizures (HP:0002373)3.61679511
4Abnormality of the axillary hair (HP:0100134)3.54301682
5Abnormality of secondary sexual hair (HP:0009888)3.54301682
6Broad-based gait (HP:0002136)3.45728769
7Abnormal sex determination (HP:0012244)3.26021246
8Sex reversal (HP:0012245)3.26021246
9Epileptic encephalopathy (HP:0200134)3.25878826
10Septo-optic dysplasia (HP:0100842)3.23730865
11Hyperventilation (HP:0002883)3.06147676
12Atonic seizures (HP:0010819)3.01227473
13Sleep apnea (HP:0010535)2.95560353
14Focal seizures (HP:0007359)2.94268222
15Myokymia (HP:0002411)2.92517970
16Split foot (HP:0001839)2.91140803
17Alacrima (HP:0000522)2.90479147
18Progressive cerebellar ataxia (HP:0002073)2.84210879
19Hepatoblastoma (HP:0002884)2.77768029
20Volvulus (HP:0002580)2.53094877
21Cutaneous finger syndactyly (HP:0010554)2.52898864
22Absent septum pellucidum (HP:0001331)2.47517150
23Esotropia (HP:0000565)2.44293151
24Congenital sensorineural hearing impairment (HP:0008527)2.44204544
25Excessive salivation (HP:0003781)2.43122310
26Drooling (HP:0002307)2.43122310
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42196892
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.42196892
29Decreased lacrimation (HP:0000633)2.40647657
30Ulnar claw (HP:0001178)2.36834054
31Abnormality of the septum pellucidum (HP:0007375)2.34654104
32Humeroradial synostosis (HP:0003041)2.34360257
33Synostosis involving the elbow (HP:0003938)2.34360257
34Limb dystonia (HP:0002451)2.33409827
35Action tremor (HP:0002345)2.27376388
36Gait imbalance (HP:0002141)2.24020859
37Morphological abnormality of the middle ear (HP:0008609)2.23193744
38Cortical dysplasia (HP:0002539)2.23140545
39Peripheral hypomyelination (HP:0007182)2.22162230
40Midline defect of the nose (HP:0004122)2.20742875
41Cutaneous syndactyly (HP:0012725)2.20647570
42* Optic nerve hypoplasia (HP:0000609)2.19621807
43Bifid tongue (HP:0010297)2.19321523
44Vertebral arch anomaly (HP:0008438)2.18786657
45Abnormality of the phalanges of the hallux (HP:0010057)2.18586092
46Gaze-evoked nystagmus (HP:0000640)2.15277281
47Blue irides (HP:0000635)2.15197499
48Short tibia (HP:0005736)2.14466974
49High anterior hairline (HP:0009890)2.13563486
50Renal hypoplasia (HP:0000089)2.13059722
51Neonatal short-limb short stature (HP:0008921)2.11470796
52Myelomeningocele (HP:0002475)2.10314678
53Papillary thyroid carcinoma (HP:0002895)2.10072517
54Shawl scrotum (HP:0000049)2.08394657
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.08279864
56Chin dimple (HP:0010751)2.07895901
57Thyroid-stimulating hormone excess (HP:0002925)2.07843561
58White forelock (HP:0002211)2.07064599
59Fibular aplasia (HP:0002990)2.06084562
60Medial flaring of the eyebrow (HP:0010747)2.04837089
61Nonprogressive disorder (HP:0003680)2.03903599
62Anophthalmia (HP:0000528)2.03130705
63Abnormality of the corticospinal tract (HP:0002492)2.01865173
64Agitation (HP:0000713)2.01209208
65Dialeptic seizures (HP:0011146)2.01047756
66Esophageal atresia (HP:0002032)2.01036250
67Labial hypoplasia (HP:0000066)2.00826835
68Aplasia involving bones of the upper limbs (HP:0009823)1.99215561
69Aplasia of the phalanges of the hand (HP:0009802)1.99215561
70Aplasia involving bones of the extremities (HP:0009825)1.99215561
71Arterial tortuosity (HP:0005116)1.99191109
72Retinal dysplasia (HP:0007973)1.97820326
73Sensory axonal neuropathy (HP:0003390)1.97541921
74Hypothermia (HP:0002045)1.97526433
75Attenuation of retinal blood vessels (HP:0007843)1.96572109
76Aqueductal stenosis (HP:0002410)1.96157213
77Oligodactyly (hands) (HP:0001180)1.95261401
78Abnormal hair whorl (HP:0010721)1.95018127
79Absence seizures (HP:0002121)1.94306404
80Missing ribs (HP:0000921)1.92410431
81Keratoconus (HP:0000563)1.92024522
82Increased corneal curvature (HP:0100692)1.92024522
83Protruding tongue (HP:0010808)1.92010104
84* Absent speech (HP:0001344)1.91621253
85Genital tract atresia (HP:0001827)1.91391107
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91370028
87Hypoplastic labia majora (HP:0000059)1.90440229
88Atrophic scars (HP:0001075)1.90074644
89Progressive inability to walk (HP:0002505)1.89018060
90Vaginal atresia (HP:0000148)1.88688278
91Corneal dystrophy (HP:0001131)1.88594922
92Aplasia/Hypoplasia of the lens (HP:0008063)1.88046425
93Patchy hypopigmentation of hair (HP:0011365)1.87188597
94Abnormality of incisor morphology (HP:0011063)1.86767542
95Akinesia (HP:0002304)1.86560427
96Scanning speech (HP:0002168)1.85605597
97Fetal akinesia sequence (HP:0001989)1.84998881
98Narrow nasal bridge (HP:0000446)1.84993383
99Parakeratosis (HP:0001036)1.83568708
100Bradycardia (HP:0001662)1.83435331
101Decreased central vision (HP:0007663)1.83117974
102Thickened helices (HP:0000391)1.82850109
103Congenital primary aphakia (HP:0007707)1.82731872
104Hypoplastic female external genitalia (HP:0012815)1.82520524
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.82005604
106Absent/shortened dynein arms (HP:0200106)1.82005604
107Microglossia (HP:0000171)1.81223919
108Coronal craniosynostosis (HP:0004440)1.79075897
109Generalized tonic-clonic seizures (HP:0002069)1.78845834
110Short 4th metacarpal (HP:0010044)1.78699920
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78699920
112Abnormality of salivation (HP:0100755)1.78557415
113Inability to walk (HP:0002540)1.78169512
114Bronchomalacia (HP:0002780)1.77961511
115Concave nail (HP:0001598)1.77226403
116Shallow orbits (HP:0000586)1.76814076
117Hyperthyroidism (HP:0000836)1.75977823
118Abnormality of the nasolacrimal system (HP:0000614)1.75566415
119Vascular tortuosity (HP:0004948)1.75137445
120Absent eyebrow (HP:0002223)1.74981093
121Exotropia (HP:0000577)1.74781579
122Preaxial foot polydactyly (HP:0001841)1.73709533
123Gastroesophageal reflux (HP:0002020)1.73671812
124Abnormality of the nasal septum (HP:0000419)1.72434533
125Submucous cleft hard palate (HP:0000176)1.72095516
126Symphalangism affecting the phalanges of the hand (HP:0009773)1.71623297
127Megalencephaly (HP:0001355)1.71397406
128Conical tooth (HP:0000698)1.71326753
129Aplasia cutis congenita (HP:0001057)1.70902303
130Laryngomalacia (HP:0001601)1.70661859
131Abnormality of the aortic arch (HP:0012303)1.70522082
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.70232102
133Wide anterior fontanel (HP:0000260)1.68865130
134Abnormality of the ischium (HP:0003174)1.68305907
135Increased nuchal translucency (HP:0010880)1.68194750
136Curly hair (HP:0002212)1.67906639
137Omphalocele (HP:0001539)1.67885935
138Abnormality of the labia majora (HP:0012881)1.64774007
139Turricephaly (HP:0000262)1.64566944
140Intestinal atresia (HP:0011100)1.64363062
141Pulmonic stenosis (HP:0001642)1.64085532
142Gastrointestinal atresia (HP:0002589)1.63131465
143Right ventricular cardiomyopathy (HP:0011663)1.62733088
144Vertebral clefting (HP:0008428)1.61590430
145Abnormal pancreas size (HP:0012094)1.59920729
146Hemivertebrae (HP:0002937)1.58739119
147Vitreoretinal degeneration (HP:0000655)1.56810398
148Overgrowth (HP:0001548)1.55990870
149Abnormality of the labia minora (HP:0012880)1.54959911
150Abnormality of the antihelix (HP:0009738)1.54427156
151Large earlobe (HP:0009748)1.53325874
152Abnormality of the 4th metacarpal (HP:0010012)1.51004518
153Renal duplication (HP:0000075)1.50455063
154Broad finger (HP:0001500)1.49668883
155Broad thumb (HP:0011304)1.49498118
156Increased number of teeth (HP:0011069)1.48636178
157Renovascular hypertension (HP:0100817)1.47499002
158Colon cancer (HP:0003003)1.47150098
159Abnormality of the lower motor neuron (HP:0002366)1.45806430
160Arnold-Chiari malformation (HP:0002308)1.45686250
161Heterotopia (HP:0002282)1.45341442
162Pterygium (HP:0001059)1.44008231
163Broad long bones (HP:0005622)1.43834534
164Abnormality of dentin (HP:0010299)1.43397527
165Oligodactyly (HP:0012165)1.43106007
166Micropenis (HP:0000054)1.42681610
167Broad metatarsal (HP:0001783)1.42528432
168Abnormality of the distal phalanx of the thumb (HP:0009617)1.42104172
169Choanal stenosis (HP:0000452)1.41749278
170Overriding aorta (HP:0002623)1.41430769
171Absent eyelashes (HP:0000561)1.41205384
172Insidious onset (HP:0003587)1.41191285
173Termporal pattern (HP:0011008)1.41191285
174Wide intermamillary distance (HP:0006610)1.40828849
175Short metatarsal (HP:0010743)1.40284158
176Short middle phalanx of finger (HP:0005819)1.40000369
177Cupped ear (HP:0000378)1.39772095
178Abnormality of the diencephalon (HP:0010662)1.39144448
179Bifid scrotum (HP:0000048)1.39140467
180Obsessive-compulsive behavior (HP:0000722)1.38519033
181Tibial bowing (HP:0002982)1.38515308
182Abnormality of the dental root (HP:0006486)1.38417581
183Taurodontia (HP:0000679)1.38417581
184Abnormality of permanent molar morphology (HP:0011071)1.38417581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* CASK5.99563097
2MKNK23.32671054
3MARK13.06016543
4MAP3K92.66570447
5NTRK32.47065209
6MAP2K72.43500596
7PRPF4B2.31501924
8TNIK2.21461220
9MAPK132.14100333
10PHKG12.12440180
11PHKG22.12440180
12MKNK11.92191564
13EPHA41.83883142
14AKT31.81581623
15MAP3K41.74784045
16STK38L1.74490631
17CAMK1G1.72127313
18PKN11.69049842
19TLK11.67434501
20MET1.66788838
21MUSK1.60915959
22NTRK21.57923793
23YES11.55504652
24STK391.54989298
25LATS11.53516627
26DYRK21.49462781
27PDGFRA1.43981263
28TAF11.43181743
29OXSR11.37748714
30TRIM281.35096802
31UHMK11.34302856
32PLK21.29307118
33FES1.27383762
34TYRO31.26592652
35KSR11.23509705
36FER1.20988326
37BMPR1B1.19830441
38SGK4941.19543444
39SGK2231.19543444
40MST1R1.16412839
41EPHA21.16209716
42MINK11.13974882
43PRKD31.12726769
44SGK21.08441997
45TSSK61.04722500
46GRK71.03357966
47CDK191.03008664
48PRKCE1.01968905
49CAMK2A1.01557626
50CAMK2B0.98426007
51IRAK20.98118860
52BCR0.97674112
53CDK30.97009034
54ADRBK20.96933254
55DAPK20.96825665
56INSRR0.96377079
57FGR0.95669879
58FGFR10.93428792
59DYRK1A0.91722235
60BRD40.90817940
61IRAK10.89783728
62DMPK0.87972833
63CSNK1G10.87813658
64PRKD20.87228450
65GRK10.87106031
66NTRK10.86545813
67NEK60.86482865
68PTK20.86449241
69CSNK1G20.86403805
70MAPK150.85926293
71EPHB20.85675928
72MAP3K100.85266108
73EIF2AK20.84532029
74CAMK1D0.84147969
75CLK10.80502058
76ERBB40.80487721
77SRPK10.79742501
78* CDK50.78999609
79CSNK1A1L0.78697441
80CSNK1G30.78304012
81RIPK10.77973624
82PRKCG0.77957933
83LMTK20.76321392
84DYRK30.73981889
85MAP3K120.73785768
86DDR20.73459492
87MAP2K40.73181690
88ADRBK10.73047962
89EPHA30.71425708
90STK30.71254046
91PDGFRB0.69682067
92ROCK20.69524283
93PAK60.68240946
94WNK10.66579228
95SIK20.64850034
96GRK50.64133498
97STK110.61423492
98BMPR20.60374385
99ROCK10.60316406
100PRKG10.59000326
101PNCK0.58720994
102CSNK1E0.58517264
103ERBB30.57948814
104WEE10.56774200
105ERBB20.56468995
106MARK20.54342676
107BRSK20.54054095
108CAMK10.53736626
109CAMK2D0.53533375
110STK160.51076960
111NUAK10.50879302
112NLK0.50209208
113SGK10.48096813
114FGFR20.46550835
115MELK0.46533531
116CAMK2G0.46360974
117ICK0.46297626
118PRKCZ0.45550908
119LIMK10.44758671
120PIK3CA0.42900098
121RPS6KB10.42673948
122STK240.42108115
123CDK140.41985053
124MAP3K10.41707353
125CSNK1D0.41157321
126PRKDC0.40991129
127PRKACA0.40660620
128PLK30.40398757
129PKN20.39352232
130WNK30.39350750
131SGK30.39266927
132CDK120.39033440
133GSK3A0.38585092
134BRAF0.38380691
135BLK0.38122088
136LATS20.37909244
137MTOR0.37445078
138CDK150.37122457
139WNK40.36716869
140SIK30.36083453
141PAK30.35980901
142CDK180.35739592
143MAPKAPK50.34835526
144RPS6KA20.34694719
145ATM0.34650289

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53646515
2Phototransduction_Homo sapiens_hsa047442.50791468
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42630037
4Axon guidance_Homo sapiens_hsa043602.39674006
5Morphine addiction_Homo sapiens_hsa050322.30913125
6Glutamatergic synapse_Homo sapiens_hsa047242.20411646
7Synaptic vesicle cycle_Homo sapiens_hsa047212.17517775
8Long-term depression_Homo sapiens_hsa047302.12666510
9Adherens junction_Homo sapiens_hsa045202.12507771
10GABAergic synapse_Homo sapiens_hsa047272.12091143
11Serotonergic synapse_Homo sapiens_hsa047262.08526181
12Olfactory transduction_Homo sapiens_hsa047402.04882792
13Circadian entrainment_Homo sapiens_hsa047131.99437706
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95063297
15Taste transduction_Homo sapiens_hsa047421.92356885
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88761173
17Dopaminergic synapse_Homo sapiens_hsa047281.74448136
18Amphetamine addiction_Homo sapiens_hsa050311.69707672
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.65603434
20Cholinergic synapse_Homo sapiens_hsa047251.59562840
21Salivary secretion_Homo sapiens_hsa049701.56884111
22Cocaine addiction_Homo sapiens_hsa050301.55766376
23Melanogenesis_Homo sapiens_hsa049161.52757057
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50923997
25Renin secretion_Homo sapiens_hsa049241.50845331
26TGF-beta signaling pathway_Homo sapiens_hsa043501.46965606
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44060902
28Long-term potentiation_Homo sapiens_hsa047201.40432236
29Calcium signaling pathway_Homo sapiens_hsa040201.38679822
30Gap junction_Homo sapiens_hsa045401.37196270
31Insulin secretion_Homo sapiens_hsa049111.34495803
32Wnt signaling pathway_Homo sapiens_hsa043101.33142118
33Basal cell carcinoma_Homo sapiens_hsa052171.32987278
34Hedgehog signaling pathway_Homo sapiens_hsa043401.32724256
35Protein digestion and absorption_Homo sapiens_hsa049741.30149699
36ErbB signaling pathway_Homo sapiens_hsa040121.28620509
37Sphingolipid metabolism_Homo sapiens_hsa006001.26814225
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24850126
39Collecting duct acid secretion_Homo sapiens_hsa049661.23689744
40Vibrio cholerae infection_Homo sapiens_hsa051101.23129747
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22620006
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20399610
43Ether lipid metabolism_Homo sapiens_hsa005651.19964531
44GnRH signaling pathway_Homo sapiens_hsa049121.15240645
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14935255
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13911438
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13671074
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11185179
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10895283
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09273790
51Oxytocin signaling pathway_Homo sapiens_hsa049211.08442486
52Gastric acid secretion_Homo sapiens_hsa049711.08362451
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06417303
54Thyroid cancer_Homo sapiens_hsa052161.03477227
55Melanoma_Homo sapiens_hsa052181.03297663
56Ras signaling pathway_Homo sapiens_hsa040140.99461728
57cAMP signaling pathway_Homo sapiens_hsa040240.98463352
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95946698
59Lysine degradation_Homo sapiens_hsa003100.94616723
60Thyroid hormone synthesis_Homo sapiens_hsa049180.93874576
61Bile secretion_Homo sapiens_hsa049760.93335586
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92114754
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89564755
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88590913
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.85841713
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84406652
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83942250
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83655674
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82926465
70Vitamin B6 metabolism_Homo sapiens_hsa007500.82868899
71Proteoglycans in cancer_Homo sapiens_hsa052050.82420342
72Glioma_Homo sapiens_hsa052140.79916996
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78244488
74MAPK signaling pathway_Homo sapiens_hsa040100.76970152
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76945487
76Oxidative phosphorylation_Homo sapiens_hsa001900.75123721
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74530160
78Steroid biosynthesis_Homo sapiens_hsa001000.73248240
79Ovarian steroidogenesis_Homo sapiens_hsa049130.72194677
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71766526
81Estrogen signaling pathway_Homo sapiens_hsa049150.71137534
82Fat digestion and absorption_Homo sapiens_hsa049750.71087668
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.69253054
84Retinol metabolism_Homo sapiens_hsa008300.68488570
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67943176
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66736409
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.66679693
88Alcoholism_Homo sapiens_hsa050340.66505910
89Choline metabolism in cancer_Homo sapiens_hsa052310.65681006
90Protein export_Homo sapiens_hsa030600.65178440
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64560881
92Alzheimers disease_Homo sapiens_hsa050100.64470811
93Hippo signaling pathway_Homo sapiens_hsa043900.64149165
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63338363
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.63220919
96Rap1 signaling pathway_Homo sapiens_hsa040150.63084001
97Prostate cancer_Homo sapiens_hsa052150.62755449
98Fatty acid elongation_Homo sapiens_hsa000620.62606880
99Starch and sucrose metabolism_Homo sapiens_hsa005000.62152703
100Oocyte meiosis_Homo sapiens_hsa041140.61071424
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60752780
102Propanoate metabolism_Homo sapiens_hsa006400.59330196
103mRNA surveillance pathway_Homo sapiens_hsa030150.59133675
104Cardiac muscle contraction_Homo sapiens_hsa042600.58871303
105Dilated cardiomyopathy_Homo sapiens_hsa054140.58208657
106Renal cell carcinoma_Homo sapiens_hsa052110.57586451
107Phagosome_Homo sapiens_hsa041450.57341704
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56510200
109Notch signaling pathway_Homo sapiens_hsa043300.55639414
110Caffeine metabolism_Homo sapiens_hsa002320.55394268
111Vitamin digestion and absorption_Homo sapiens_hsa049770.55172086
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54935060
113Glucagon signaling pathway_Homo sapiens_hsa049220.54412562
114AMPK signaling pathway_Homo sapiens_hsa041520.54304608
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52921871
116Rheumatoid arthritis_Homo sapiens_hsa053230.51344631
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50468559
118Endometrial cancer_Homo sapiens_hsa052130.50434278
119Mineral absorption_Homo sapiens_hsa049780.50021721
120Pancreatic secretion_Homo sapiens_hsa049720.49476445
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.49102213
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.48126138
123Cell cycle_Homo sapiens_hsa041100.48009439
124ECM-receptor interaction_Homo sapiens_hsa045120.47461086
125Circadian rhythm_Homo sapiens_hsa047100.46755126
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46444697
127Dorso-ventral axis formation_Homo sapiens_hsa043200.43483452
128Pathways in cancer_Homo sapiens_hsa052000.40085937
129Arachidonic acid metabolism_Homo sapiens_hsa005900.40075641
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39331814
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38893553
132Focal adhesion_Homo sapiens_hsa045100.38176825
133Colorectal cancer_Homo sapiens_hsa052100.36650316
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36373493
135MicroRNAs in cancer_Homo sapiens_hsa052060.35961602
136Type II diabetes mellitus_Homo sapiens_hsa049300.35593811
137* Tight junction_Homo sapiens_hsa045300.34636495

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