CASKIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1semaphorin-plexin signaling pathway (GO:0071526)4.74033921
2cardiac myofibril assembly (GO:0055003)4.73757296
3vascular endothelial growth factor signaling pathway (GO:0038084)4.52028101
4sarcomere organization (GO:0045214)4.33576915
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.27796084
6heart trabecula formation (GO:0060347)3.97272582
7myofibril assembly (GO:0030239)3.97133854
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.93094908
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.92774987
10plasma membrane repair (GO:0001778)3.91280157
11retina vasculature morphogenesis in camera-type eye (GO:0061299)3.90024161
12surfactant homeostasis (GO:0043129)3.71976373
13cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.67874297
14negative regulation of cell size (GO:0045792)3.67029084
15negative regulation of potassium ion transmembrane transport (GO:1901380)3.59951435
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.54099661
17regulation of cardioblast differentiation (GO:0051890)3.53586244
18renal filtration (GO:0097205)3.49958626
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.49442190
20regulation of female receptivity (GO:0045924)3.47900332
21lymph vessel development (GO:0001945)3.43398244
22focal adhesion assembly (GO:0048041)3.41311292
23cell-substrate adherens junction assembly (GO:0007045)3.41311292
24glomerular filtration (GO:0003094)3.40922673
25endothelial cell chemotaxis (GO:0035767)3.35987323
26carnitine shuttle (GO:0006853)3.33810280
27ventricular cardiac muscle cell action potential (GO:0086005)3.33681283
28actomyosin structure organization (GO:0031032)3.31473913
29basement membrane organization (GO:0071711)3.30353723
30regulation of p38MAPK cascade (GO:1900744)3.30277395
31desmosome organization (GO:0002934)3.27264436
32lymphangiogenesis (GO:0001946)3.23897257
33proline metabolic process (GO:0006560)3.20977533
34blood vessel maturation (GO:0001955)3.17363585
35fatty acid transmembrane transport (GO:1902001)3.17302585
36insulin-like growth factor receptor signaling pathway (GO:0048009)3.16716437
37creatine metabolic process (GO:0006600)3.14873812
38endothelial cell morphogenesis (GO:0001886)3.14470213
39cardiac muscle cell development (GO:0055013)3.12669652
40hemidesmosome assembly (GO:0031581)3.11632371
41cell migration involved in sprouting angiogenesis (GO:0002042)3.11375679
42venous blood vessel morphogenesis (GO:0048845)3.11249531
43atrioventricular valve morphogenesis (GO:0003181)3.10625719
44protein localization to endosome (GO:0036010)3.10368864
45adhesion of symbiont to host (GO:0044406)3.07985086
46ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.07542745
47cardiac cell development (GO:0055006)3.06158935
48regulation of actin filament-based movement (GO:1903115)3.05723490
49lysine catabolic process (GO:0006554)3.04020271
50lysine metabolic process (GO:0006553)3.04020271
51peptidyl-tyrosine autophosphorylation (GO:0038083)3.02817127
52cell-cell junction maintenance (GO:0045217)3.01727666
53muscle filament sliding (GO:0030049)3.01609040
54actin-myosin filament sliding (GO:0033275)3.01609040
55cardiac muscle contraction (GO:0060048)2.99570434
56blood vessel endothelial cell migration (GO:0043534)2.99002962
57regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98156745
58epithelial cell-cell adhesion (GO:0090136)2.93513231
59regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.93094580
60female mating behavior (GO:0060180)2.93006995
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90901314
62regulation of endothelial cell differentiation (GO:0045601)2.90344494
63cardiac muscle tissue morphogenesis (GO:0055008)2.90138291
64trabecula formation (GO:0060343)2.85748914
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.84559194
66regulation of cholesterol biosynthetic process (GO:0045540)2.84003481
67apoptotic process involved in morphogenesis (GO:0060561)2.81729947
68lung epithelium development (GO:0060428)2.80136700
69chemical homeostasis within a tissue (GO:0048875)2.79488205
70proline biosynthetic process (GO:0006561)2.78398624
71regulation of skeletal muscle contraction (GO:0014819)2.78385541
72protein retention in ER lumen (GO:0006621)2.78254323
73aspartate family amino acid catabolic process (GO:0009068)2.76280569
74glomerular basement membrane development (GO:0032836)2.76087693
75cell-substrate junction assembly (GO:0007044)2.74737020
76positive regulation of p38MAPK cascade (GO:1900745)2.74333826
77Golgi transport vesicle coating (GO:0048200)2.72894981
78COPI coating of Golgi vesicle (GO:0048205)2.72894981
79cell communication involved in cardiac conduction (GO:0086065)2.72529486
80fatty acid beta-oxidation (GO:0006635)2.71285400
81virion attachment to host cell (GO:0019062)2.70423154
82adhesion of symbiont to host cell (GO:0044650)2.70423154
83establishment of apical/basal cell polarity (GO:0035089)2.69514546
84tricarboxylic acid cycle (GO:0006099)2.69194409
85protein heterotrimerization (GO:0070208)2.68854264
86vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68127425
87Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68089399
88adult heart development (GO:0007512)2.67601374
89outflow tract septum morphogenesis (GO:0003148)2.67383932
90transcytosis (GO:0045056)2.67164899
91maternal placenta development (GO:0001893)2.66928357
92regulation of extracellular matrix disassembly (GO:0010715)2.65582732
93carnitine transmembrane transport (GO:1902603)2.64658241
94carnitine transport (GO:0015879)2.64130108
95amino-acid betaine transport (GO:0015838)2.64130108
96endothelium development (GO:0003158)2.64074620
97muscle tissue morphogenesis (GO:0060415)2.63828131
98convergent extension (GO:0060026)2.63265734
99actin-mediated cell contraction (GO:0070252)2.62136871
100adherens junction assembly (GO:0034333)2.61276999
101regulation of glucose import in response to insulin stimulus (GO:2001273)2.60184719
102coronary vasculature morphogenesis (GO:0060977)2.59701396
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58665215
104branching involved in salivary gland morphogenesis (GO:0060445)2.58515306
1052-oxoglutarate metabolic process (GO:0006103)2.56621115
106regulation of fatty acid oxidation (GO:0046320)2.55216021
107negative regulation of catenin import into nucleus (GO:0035414)2.53256424
108response to mercury ion (GO:0046689)2.52185965
109negative regulation of fatty acid transport (GO:2000192)2.52072469
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50457839
111regulation of establishment of planar polarity (GO:0090175)2.49788184
112polarized epithelial cell differentiation (GO:0030859)2.49541440
113morphogenesis of an endothelium (GO:0003159)2.49370558
114endothelial tube morphogenesis (GO:0061154)2.49370558
115regulation of cholesterol homeostasis (GO:2000188)2.49314666
116cell volume homeostasis (GO:0006884)2.49295347
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48911542
118regulation of fatty acid beta-oxidation (GO:0031998)2.48382072
119vasculogenesis (GO:0001570)2.48267938
120paraxial mesoderm development (GO:0048339)2.47877648
121stress granule assembly (GO:0034063)2.46964511
122patterning of blood vessels (GO:0001569)2.46733653
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46349899
124activation of Rac GTPase activity (GO:0032863)2.45839213
125regulation of vasculogenesis (GO:2001212)2.45552833
126regulation of vascular permeability (GO:0043114)2.45098466
127cell migration in hindbrain (GO:0021535)2.44896096
128low-density lipoprotein particle clearance (GO:0034383)2.44884765
129endothelial cell differentiation (GO:0045446)2.44031604
130ear development (GO:0043583)2.43484132
131regulation of the force of heart contraction (GO:0002026)2.43159518
132metanephric nephron epithelium development (GO:0072243)2.42992896
133positive regulation of synapse maturation (GO:0090129)2.42643896
134regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.42046542
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41500362
136glomerular visceral epithelial cell development (GO:0072015)2.41278418
137regulation of tight junction assembly (GO:2000810)2.40798455
138cardiac muscle cell proliferation (GO:0060038)2.39840905
139regulation of cardiac muscle cell contraction (GO:0086004)2.39713208
140regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39267554
141stress fiber assembly (GO:0043149)2.38759735
142positive regulation of receptor recycling (GO:0001921)2.38548340
143regulation of hippo signaling (GO:0035330)2.37965005
1444-hydroxyproline metabolic process (GO:0019471)2.36625299
145positive regulation of fatty acid beta-oxidation (GO:0032000)2.35778507
146positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35654914
147neural tube development (GO:0021915)2.35085780
148cell migration involved in heart development (GO:0060973)2.34783739
149positive regulation of vasculogenesis (GO:2001214)2.33831158
150negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33815117
151cell junction maintenance (GO:0034331)2.30442444
152heart valve morphogenesis (GO:0003179)2.24711679
153non-canonical Wnt signaling pathway (GO:0035567)2.24183732
154regulation of axon extension involved in axon guidance (GO:0048841)2.23225491
155neuronal ion channel clustering (GO:0045161)2.21969397
156neuromuscular junction development (GO:0007528)2.20472820
157regulation of early endosome to late endosome transport (GO:2000641)2.20177669
158regulation of synapse maturation (GO:0090128)2.19909399
159establishment of epithelial cell polarity (GO:0090162)2.18896721
160cochlea morphogenesis (GO:0090103)2.15637781
161sodium ion export (GO:0071436)2.14993341
162response to food (GO:0032094)2.13576214
163camera-type eye morphogenesis (GO:0048593)2.13565538
164adherens junction organization (GO:0034332)2.10762683
165positive regulation of blood vessel endothelial cell migration (GO:0043536)2.10169001
166extracellular matrix assembly (GO:0085029)2.08785747
167peripheral nervous system axon ensheathment (GO:0032292)2.08471620
168myelination in peripheral nervous system (GO:0022011)2.08471620
169regulation of cholesterol metabolic process (GO:0090181)2.08157086
170cell communication by electrical coupling (GO:0010644)2.07443317
171negative regulation of cell fate specification (GO:0009996)2.07033392
172apoptotic process involved in development (GO:1902742)2.06457228
173establishment or maintenance of monopolar cell polarity (GO:0061339)2.06290608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40917263
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.67542501
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.47388895
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.19094491
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.03504662
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72058557
7CLOCK_20551151_ChIP-Seq_293T_Human2.71913504
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.66953138
9ZNF263_19887448_ChIP-Seq_K562_Human2.52001378
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.27974935
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21458116
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.16324663
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.16089645
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.14079186
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.14079186
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12467380
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06404446
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.02165575
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99606704
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99593909
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.97602250
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95546282
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.92502822
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91122785
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88620304
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87398049
27* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86330538
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82196337
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.79621726
30RACK7_27058665_Chip-Seq_MCF-7_Human1.79236128
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79137011
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79129369
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72328864
34* TET1_21451524_ChIP-Seq_MESCs_Mouse1.66720158
35LXR_22292898_ChIP-Seq_THP-1_Human1.65413998
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64946242
37SMC4_20622854_ChIP-Seq_HELA_Human1.61275979
38KDM2B_26808549_Chip-Seq_K562_Human1.59127272
39* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56951170
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56591436
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55884287
42TCF7_22412390_ChIP-Seq_EML_Mouse1.52547815
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52315318
44GATA1_19941826_ChIP-Seq_K562_Human1.51069944
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50270617
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46415494
47KDM2B_26808549_Chip-Seq_DND41_Human1.45521225
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45290142
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41359277
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41211073
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.40603769
52VDR_21846776_ChIP-Seq_THP-1_Human1.40459184
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.40147491
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38052752
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37233936
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37109334
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36621053
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36431588
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35458150
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35413628
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.34948990
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.34334684
63* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34249956
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.32578353
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32546477
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32521892
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31352400
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26128805
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24732918
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23927098
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.20846177
72* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20768905
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20140448
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18478505
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18207198
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17173876
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.16582491
78SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15818168
79* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14643120
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14633339
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14406756
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.14282909
83ATF3_27146783_Chip-Seq_COLON_Human1.14014559
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13635743
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13589498
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12811231
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11756185
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10307436
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.09321545
90* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08644170
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08236685
92CREB1_26743006_Chip-Seq_LNCaP_Human1.07531675
93MYC_22102868_ChIP-Seq_BL_Human1.07381032
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07159848
95* TP63_22573176_ChIP-Seq_HFKS_Human1.06566728
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.06398399
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05711437
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05219136
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05132031
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04989196
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04961969
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04723938
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04253171
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04115442
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04009570
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04009570
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04009570
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.03688746
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03473018
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03375829
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.03070148
112SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02927384
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01656130
114CTCF_27219007_Chip-Seq_Bcells_Human1.01000123
115TP53_22127205_ChIP-Seq_IMR90_Human1.00869705
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.00794607
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99692494
118* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99507326
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98373799
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98008973
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97846651
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97623261
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97461767
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96869227
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96682890
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95897693
127P68_20966046_ChIP-Seq_HELA_Human0.95531536
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95484446
129CJUN_26792858_Chip-Seq_BT549_Human0.94809441
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94758722
131RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93709124
132EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93709124
133AHR_22903824_ChIP-Seq_MCF-7_Human0.91875516
134DROSHA_22980978_ChIP-Seq_HELA_Human0.90538249
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90529367
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90138595
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90123469
138GATA2_19941826_ChIP-Seq_K562_Human0.90027094
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89867714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.04350096
2MP0010368_abnormal_lymphatic_system3.96188972
3MP0002837_dystrophic_cardiac_calcinosis3.42626195
4MP0004272_abnormal_basement_membrane3.37787871
5MP0000751_myopathy3.19075105
6MP0003705_abnormal_hypodermis_morpholog3.01158787
7MP0004036_abnormal_muscle_relaxation2.81557837
8MP0004215_abnormal_myocardial_fiber2.60729522
9MP0001879_abnormal_lymphatic_vessel2.55795079
10MP0005330_cardiomyopathy2.52425706
11MP0002249_abnormal_larynx_morphology2.51996074
12MP0005409_darkened_coat_color2.34097286
13MP0006138_congestive_heart_failure2.30331726
14MP0000566_synostosis2.23600979
15MP0008438_abnormal_cutaneous_collagen2.22933940
16MP0005167_abnormal_blood-brain_barrier2.15430172
17MP0008775_abnormal_heart_ventricle2.15111124
18MP0005076_abnormal_cell_differentiation2.12410116
19MP0003828_pulmonary_edema2.10212786
20MP0000749_muscle_degeneration2.06556348
21MP0001958_emphysema2.04000808
22MP0004087_abnormal_muscle_fiber2.03571417
23MP0010630_abnormal_cardiac_muscle1.98907386
24MP0001544_abnormal_cardiovascular_syste1.92023259
25MP0005385_cardiovascular_system_phenoty1.92023259
26MP0002972_abnormal_cardiac_muscle1.91395322
27MP0003646_muscle_fatigue1.91202625
28MP0009780_abnormal_chondrocyte_physiolo1.88442793
29MP0003279_aneurysm1.86473911
30MP0005623_abnormal_meninges_morphology1.81025405
31MP0000678_abnormal_parathyroid_gland1.79149806
32MP0000750_abnormal_muscle_regeneration1.77598740
33MP0000579_abnormal_nail_morphology1.77546972
34MP0004130_abnormal_muscle_cell1.76598253
35MP0005670_abnormal_white_adipose1.71362419
36MP0003950_abnormal_plasma_membrane1.68025521
37MP0003566_abnormal_cell_adhesion1.65007489
38MP0005503_abnormal_tendon_morphology1.63163761
39MP0005620_abnormal_muscle_contractility1.63084589
40MP0003137_abnormal_impulse_conducting1.61594725
41MP0005257_abnormal_intraocular_pressure1.60038091
42MP0005666_abnormal_adipose_tissue1.58410568
43MP0000767_abnormal_smooth_muscle1.53446676
44MP0005275_abnormal_skin_tensile1.52469067
45MP0004185_abnormal_adipocyte_glucose1.52384769
46MP0004085_abnormal_heartbeat1.44893251
47MP0005360_urolithiasis1.43332705
48MP0006054_spinal_hemorrhage1.40042146
49MP0000013_abnormal_adipose_tissue1.39835907
50MP0005375_adipose_tissue_phenotype1.39671938
51MP0005058_abnormal_lysosome_morphology1.39148617
52MP0000003_abnormal_adipose_tissue1.36961456
53MP0003942_abnormal_urinary_system1.36024694
54MP0002106_abnormal_muscle_physiology1.30909971
55MP0002269_muscular_atrophy1.30621773
56MP0002089_abnormal_postnatal_growth/wei1.28878784
57MP0002877_abnormal_melanocyte_morpholog1.25304208
58MP0004484_altered_response_of1.24726143
59MP0005508_abnormal_skeleton_morphology1.24634933
60MP0000747_muscle_weakness1.23596887
61MP0005501_abnormal_skin_physiology1.23085872
62MP0003123_paternal_imprinting1.22909236
63MP0002128_abnormal_blood_circulation1.20031074
64MP0003453_abnormal_keratinocyte_physiol1.18565830
65MP0002127_abnormal_cardiovascular_syste1.18521207
66MP0005165_increased_susceptibility_to1.18210405
67MP0002060_abnormal_skin_morphology1.16217601
68MP0003252_abnormal_bile_duct1.10557912
69MP0002098_abnormal_vibrissa_morphology1.10194444
70MP0004782_abnormal_surfactant_physiolog1.10091479
71MP0000266_abnormal_heart_morphology1.10011035
72MP0003941_abnormal_skin_development1.09995351
73MP0005369_muscle_phenotype1.09612831
74MP0009840_abnormal_foam_cell1.09265118
75MP0000759_abnormal_skeletal_muscle1.09162949
76MP0002925_abnormal_cardiovascular_devel1.08133287
77MP0003283_abnormal_digestive_organ1.07833897
78MP0004145_abnormal_muscle_electrophysio1.06205564
79MP0000762_abnormal_tongue_morphology1.05641090
80MP0004043_abnormal_pH_regulation1.05380750
81MP0002139_abnormal_hepatobiliary_system1.04888271
82MP0003300_gastrointestinal_ulcer1.03798506
83MP0008961_abnormal_basal_metabolism1.01819066
84MP0009384_cardiac_valve_regurgitation1.00940291
85MP0009672_abnormal_birth_weight1.00834387
86MP0003567_abnormal_fetal_cardiomyocyte1.00325334
87MP0000733_abnormal_muscle_development1.00279166
88MP0001849_ear_inflammation0.98490386
89MP0001299_abnormal_eye_distance/0.96747526
90MP0001614_abnormal_blood_vessel0.96633589
91MP0009053_abnormal_anal_canal0.95755658
92MP0002295_abnormal_pulmonary_circulatio0.95708687
93MP0005083_abnormal_biliary_tract0.94311636
94MP0005595_abnormal_vascular_smooth0.93907451
95MP0003191_abnormal_cellular_cholesterol0.93762241
96MP0002896_abnormal_bone_mineralization0.93385089
97MP0004859_abnormal_synaptic_plasticity0.92605764
98MP0002116_abnormal_craniofacial_bone0.90986163
99MP0010234_abnormal_vibrissa_follicle0.89557151
100MP0004233_abnormal_muscle_weight0.89501797
101MP0009643_abnormal_urine_homeostasis0.88310178
102MP0000049_abnormal_middle_ear0.87330447
103MP0000343_altered_response_to0.86906111
104MP0000462_abnormal_digestive_system0.85754299
105MP0002932_abnormal_joint_morphology0.85167032
106MP0001502_abnormal_circadian_rhythm0.83691560
107MP0002697_abnormal_eye_size0.83672252
108MP0010030_abnormal_orbit_morphology0.83606924
109MP0000230_abnormal_systemic_arterial0.82676635
110MP0000537_abnormal_urethra_morphology0.82036364
111MP0005171_absent_coat_pigmentation0.81928203
112MP0002332_abnormal_exercise_endurance0.81484288
113MP0000534_abnormal_ureter_morphology0.81357568
114MP0003385_abnormal_body_wall0.81089599
115MP0009278_abnormal_bone_marrow0.80123250
116MP0008260_abnormal_autophagy0.80080970
117MP0002108_abnormal_muscle_morphology0.79991381
118MP0001348_abnormal_lacrimal_gland0.79941854
119MP0010678_abnormal_skin_adnexa0.79790121
120MP0002796_impaired_skin_barrier0.79511881
121MP0003091_abnormal_cell_migration0.79355269
122MP0000467_abnormal_esophagus_morphology0.78981992
123MP0003634_abnormal_glial_cell0.78937459
124MP0005085_abnormal_gallbladder_physiolo0.78158376
125MP0004858_abnormal_nervous_system0.77845930
126MP0003115_abnormal_respiratory_system0.77351259
127MP0001784_abnormal_fluid_regulation0.77114666
128MP0002138_abnormal_hepatobiliary_system0.76517214
129MP0005365_abnormal_bile_salt0.76259599
130MP0003221_abnormal_cardiomyocyte_apopto0.74575781
131MP0005332_abnormal_amino_acid0.74009592
132MP0005023_abnormal_wound_healing0.73997582
133MP0001340_abnormal_eyelid_morphology0.72725388
134MP0001756_abnormal_urination0.72532861
135MP0010329_abnormal_lipoprotein_level0.72217725
136MP0003045_fibrosis0.71396924
137MP0000249_abnormal_blood_vessel0.70312626
138MP0005423_abnormal_somatic_nervous0.70191461
139MP0002234_abnormal_pharynx_morphology0.69317838
140MP0005187_abnormal_penis_morphology0.69232922
141MP0003879_abnormal_hair_cell0.68158082
142MP0003329_amyloid_beta_deposits0.67813424
143MP0003935_abnormal_craniofacial_develop0.67676425
144MP0003938_abnormal_ear_development0.66178739
145MP0004381_abnormal_hair_follicle0.65837491

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.86571903
2Muscle fiber splitting (HP:0003555)4.69125831
3Ventricular tachycardia (HP:0004756)4.64328457
4Right ventricular cardiomyopathy (HP:0011663)4.39361410
5Hyporeflexia of lower limbs (HP:0002600)4.09914143
6Increased connective tissue (HP:0009025)4.06323227
7Broad metatarsal (HP:0001783)3.63459970
8Polycythemia (HP:0001901)3.49427942
9Atrial fibrillation (HP:0005110)3.47206336
10Difficulty running (HP:0009046)3.45424807
11Obstructive sleep apnea (HP:0002870)3.39901843
12Hyperacusis (HP:0010780)3.28943628
13Lipoatrophy (HP:0100578)3.27601106
14Exercise-induced myalgia (HP:0003738)3.21580013
15Primary atrial arrhythmia (HP:0001692)3.20123895
16Supraventricular arrhythmia (HP:0005115)3.16455185
17Lymphangioma (HP:0100764)3.11606999
18Supraventricular tachycardia (HP:0004755)3.04889674
19Bundle branch block (HP:0011710)2.99653569
20Exercise-induced muscle cramps (HP:0003710)2.98825001
21Syncope (HP:0001279)2.98037310
22Ulnar bowing (HP:0003031)2.95309559
23Cerebral aneurysm (HP:0004944)2.89404417
24Myoglobinuria (HP:0002913)2.88957135
25Premature rupture of membranes (HP:0001788)2.87396579
26Abnormality of the calf musculature (HP:0001430)2.86148614
27Calf muscle hypertrophy (HP:0008981)2.85121872
28Prolonged QT interval (HP:0001657)2.84840102
29Dilated cardiomyopathy (HP:0001644)2.78089231
30Abnormality of the left ventricular outflow tract (HP:0011103)2.77672796
31Subaortic stenosis (HP:0001682)2.77672796
32Distal lower limb amyotrophy (HP:0008944)2.73134680
33Atrioventricular block (HP:0001678)2.72017215
34Protrusio acetabuli (HP:0003179)2.70061278
35Heart block (HP:0012722)2.66927751
36Broad face (HP:0000283)2.65754445
37Abnormal atrioventricular conduction (HP:0005150)2.62008380
38Difficulty climbing stairs (HP:0003551)2.58443447
39Increased variability in muscle fiber diameter (HP:0003557)2.57449150
40EMG: myopathic abnormalities (HP:0003458)2.57207651
41Asymmetric septal hypertrophy (HP:0001670)2.56220570
42J-shaped sella turcica (HP:0002680)2.56193789
43Stridor (HP:0010307)2.55463165
44Muscle hypertrophy of the lower extremities (HP:0008968)2.54957980
45Ventricular arrhythmia (HP:0004308)2.54161318
46Visceral angiomatosis (HP:0100761)2.53038115
47Mildly elevated creatine phosphokinase (HP:0008180)2.47776478
48Shallow orbits (HP:0000586)2.46387936
49Esophageal varix (HP:0002040)2.45265917
50Turricephaly (HP:0000262)2.42712955
51Type 1 muscle fiber predominance (HP:0003803)2.42103372
52Distal upper limb amyotrophy (HP:0007149)2.40757916
53Upper limb amyotrophy (HP:0009129)2.40757916
54Thin bony cortex (HP:0002753)2.39900183
55Mesangial abnormality (HP:0001966)2.38364611
56Ventricular fibrillation (HP:0001663)2.35939193
57Ketoacidosis (HP:0001993)2.35559135
58Hemangiomatosis (HP:0007461)2.34265887
59Cervical subluxation (HP:0003308)2.33103918
60Aneurysm (HP:0002617)2.29994401
61Palpitations (HP:0001962)2.26355565
62Deep venous thrombosis (HP:0002625)2.22829400
63Asymmetry of the thorax (HP:0001555)2.22538805
64Hematochezia (HP:0002573)2.21878289
65Abnormality of skeletal muscle fiber size (HP:0012084)2.20614254
66Mitral regurgitation (HP:0001653)2.20391334
67Ankle contracture (HP:0006466)2.20215143
68Hypoplastic ischia (HP:0003175)2.18527854
69Myotonia (HP:0002486)2.17023635
70Lower limb amyotrophy (HP:0007210)2.16435168
71Spinal rigidity (HP:0003306)2.16390433
72Hypoglycemic coma (HP:0001325)2.15295184
73Coronal craniosynostosis (HP:0004440)2.10035919
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07914705
75Aplasia involving bones of the extremities (HP:0009825)2.05003262
76Aplasia involving bones of the upper limbs (HP:0009823)2.05003262
77Aplasia of the phalanges of the hand (HP:0009802)2.05003262
78Neonatal death (HP:0003811)2.04239183
79Hyperglycinuria (HP:0003108)2.03238420
80Scapular winging (HP:0003691)2.02719932
81Bulbar palsy (HP:0001283)2.02688249
82Atrophic scars (HP:0001075)1.99552978
83Bladder diverticulum (HP:0000015)1.98790264
84Advanced eruption of teeth (HP:0006288)1.98660303
85Abnormality of the ischium (HP:0003174)1.97994568
86Myopathic facies (HP:0002058)1.97816542
87Hypercortisolism (HP:0001578)1.97413588
88Biconcave vertebral bodies (HP:0004586)1.96174914
89Ependymoma (HP:0002888)1.96007010
90Thin ribs (HP:0000883)1.93174778
91Nonimmune hydrops fetalis (HP:0001790)1.91488650
92Pterygium (HP:0001059)1.91205958
93Rhabdomyolysis (HP:0003201)1.90649929
94Nuclear cataract (HP:0100018)1.90354997
95Hypoplasia of the iris (HP:0007676)1.89986815
96Cerebral hemorrhage (HP:0001342)1.88315802
97Achilles tendon contracture (HP:0001771)1.88129159
98Aortic dissection (HP:0002647)1.87620507
99Ketosis (HP:0001946)1.87181493
100Pulmonary artery stenosis (HP:0004415)1.86890538
101Testicular atrophy (HP:0000029)1.86403375
102Hyperactive renin-angiotensin system (HP:0000841)1.83534882
103Cavernous hemangioma (HP:0001048)1.83206010
104Partial duplication of thumb phalanx (HP:0009944)1.81698241
105Large for gestational age (HP:0001520)1.81084161
106Fragile skin (HP:0001030)1.80220259
107Precocious puberty (HP:0000826)1.80096592
108Hyperparathyroidism (HP:0000843)1.80052184
109Aortic aneurysm (HP:0004942)1.79943763
110Short hallux (HP:0010109)1.79586685
111Abnormality of the foot musculature (HP:0001436)1.79073442
112Generalized amyotrophy (HP:0003700)1.78267805
113Insomnia (HP:0100785)1.76953748
114Abnormality of fatty-acid metabolism (HP:0004359)1.76819244
115Foot dorsiflexor weakness (HP:0009027)1.75691381
116Germ cell neoplasia (HP:0100728)1.74202870
117Gout (HP:0001997)1.73654236
118Abnormality of the 4th metacarpal (HP:0010012)1.73569570
119Venous abnormality (HP:0002624)1.72507900
120Partial duplication of the phalanx of hand (HP:0009999)1.72274680
121Bronchomalacia (HP:0002780)1.70894450
122Ileus (HP:0002595)1.70802906
123Hypokalemic alkalosis (HP:0001949)1.70090795
124Abnormality of glycine metabolism (HP:0010895)1.69729230
125Abnormality of serine family amino acid metabolism (HP:0010894)1.69729230
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.69682717
127Hip contracture (HP:0003273)1.69334523
128Distal lower limb muscle weakness (HP:0009053)1.69315228
129Round ear (HP:0100830)1.68444070
130Hemorrhage of the eye (HP:0011885)1.68378294
131Wormian bones (HP:0002645)1.68319494
132Enlarged penis (HP:0000040)1.68072962
133Abnormality of the aortic arch (HP:0012303)1.67707700
134Disproportionate tall stature (HP:0001519)1.67585955
135Spinal cord compression (HP:0002176)1.66592848
136Abnormality of the Achilles tendon (HP:0005109)1.66362874
137Pointed chin (HP:0000307)1.66321500
138Spontaneous hematomas (HP:0007420)1.66117319
139Neoplasm of the heart (HP:0100544)1.66064565
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.66052288
141Long toe (HP:0010511)1.65989391
142Vertebral compression fractures (HP:0002953)1.64922378
143Generalized muscle weakness (HP:0003324)1.64102976
144Aplasia/Hypoplasia of the hallux (HP:0008362)1.63989413
145Arnold-Chiari malformation (HP:0002308)1.63762189
146Rectal prolapse (HP:0002035)1.63642352
147Bell-shaped thorax (HP:0001591)1.63578276
148Palmoplantar keratoderma (HP:0000982)1.63184435
149Diaphragmatic weakness (HP:0009113)1.63169320
150Back pain (HP:0003418)1.62569438
151Increased circulating renin level (HP:0000848)1.61834300
152Overriding aorta (HP:0002623)1.61714228
153Axonal loss (HP:0003447)1.61185804
154Abnormal EKG (HP:0003115)1.60912041
155Hyperammonemia (HP:0001987)1.60415878
156Acanthosis nigricans (HP:0000956)1.60018778
157Congenital glaucoma (HP:0001087)1.59961399
158Wrist flexion contracture (HP:0001239)1.59234067
159Vascular tortuosity (HP:0004948)1.59171893
160Flat acetabular roof (HP:0003180)1.58439373
161Easy fatigability (HP:0003388)1.57620842
162Joint stiffness (HP:0001387)1.57407822
163Bowel diverticulosis (HP:0005222)1.56583458
164Natal tooth (HP:0000695)1.55263291
165Deformed sella turcica (HP:0002681)1.55115935
166Hypercalcemia (HP:0003072)1.54780231
167Premature skin wrinkling (HP:0100678)1.54619122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.53162109
2TRIB33.95944753
3TTN3.41932865
4KDR3.16778771
5PKN22.65175044
6RIPK12.50994203
7MST1R2.49854821
8WNK42.46468991
9SMG12.38253492
10LMTK22.31433315
11TGFBR22.19301929
12ERN12.18273312
13PDGFRA2.18142001
14DMPK2.05369523
15EPHB11.96183506
16STK391.95456115
17MYLK1.93740646
18TESK11.88884921
19EPHB21.87793933
20PHKG11.80613706
21PHKG21.80613706
22LATS11.68368196
23PTK61.68337649
24ICK1.65470920
25BCKDK1.64298133
26SIK11.43445571
27NME21.40990222
28MAP3K101.30954321
29RPS6KA21.26203190
30PRKD11.24498596
31TGFBR11.20800951
32PRPF4B1.18710237
33PRKD31.18336738
34MET1.16291349
35MAP3K61.12555529
36LATS21.11577670
37OXSR11.09165141
38FER1.05175075
39PRKCI1.03545251
40PAK31.03392407
41OBSCN1.02217793
42PAK41.01132888
43PTK2B1.00697332
44DDR21.00579916
45LRRK20.98874458
46PDK20.97994917
47CDK120.96543005
48MAP2K20.96444545
49FGFR40.94074610
50MAP3K30.93111279
51PTK20.92307041
52PDK30.91069260
53PDK40.91069260
54MAP2K30.90944369
55MAP3K70.86763973
56ILK0.86146167
57PAK20.84599073
58IRAK30.84570366
59NTRK30.84114684
60NME10.83610123
61BMX0.80338568
62MTOR0.79269201
63PDGFRB0.79235287
64PRKAA20.77504155
65FGFR20.75349321
66WNK10.75060392
67RPS6KC10.74537902
68RPS6KL10.74537902
69EPHA20.72972193
70PRKD20.72835226
71PIK3CA0.71081000
72ROCK10.70108819
73TYRO30.70042062
74PRKG20.69931152
75KSR20.69628136
76PRKCH0.68907232
77RET0.68119834
78RPS6KB20.67549437
79CDK70.65717320
80CAMK2G0.65361479
81MAPK150.64611408
82CDC42BPA0.62388204
83PDPK10.62201646
84CDK150.61911584
85CDK11A0.60538261
86MUSK0.60524007
87CAMK1G0.60310348
88NEK60.58910191
89CAMK2B0.58245742
90STK38L0.58198706
91EEF2K0.57635457
92CAMK1D0.57490302
93MAPK120.57067176
94GSK3A0.56870198
95ROCK20.56355285
96RPS6KA60.56255833
97CDK180.55249664
98AKT20.53364196
99TAOK10.52599374
100MAPKAPK30.50675909
101INSRR0.49934142
102MATK0.49898501
103TAOK20.49742491
104ERBB20.48484893
105PRKAA10.48359858
106MAP2K10.47355994
107LIMK10.46239081
108MAP3K10.44543033
109NTRK10.43695711
110TRPM70.43322365
111HIPK20.41922523
112MAPK80.41644000
113STK380.41440269
114ARAF0.40622453
115MAP3K90.40090261
116CDK140.39192423
117RPS6KA10.38859717
118MAP3K110.38411373
119MAPK100.38136189
120MARK20.37842703
121PAK60.37386156
122STK100.37081917
123CAMKK10.36810074
124MAPK70.36616002
125STK30.36481216
126CAMK40.36411859
127PKN10.33675448
128CAMK2D0.33415021
129DAPK30.33028604
130NEK10.32854049
131MAPK40.32335094
132CAMK10.32068742
133PINK10.30637961
134STK40.30429216
135JAK20.29619241
136MAP3K20.28799728

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.91279069
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90595147
3Fatty acid degradation_Homo sapiens_hsa000712.70503776
4Nitrogen metabolism_Homo sapiens_hsa009102.57868988
5Propanoate metabolism_Homo sapiens_hsa006402.42702364
6Dilated cardiomyopathy_Homo sapiens_hsa054142.33544386
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28139545
8Fatty acid metabolism_Homo sapiens_hsa012122.26622696
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.15879296
10ECM-receptor interaction_Homo sapiens_hsa045121.99240293
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98706232
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90588487
13Sulfur relay system_Homo sapiens_hsa041221.80639461
14PPAR signaling pathway_Homo sapiens_hsa033201.77829600
15Phenylalanine metabolism_Homo sapiens_hsa003601.72868744
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.71746845
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68511330
18Focal adhesion_Homo sapiens_hsa045101.67532604
19Arginine biosynthesis_Homo sapiens_hsa002201.60057286
20Tryptophan metabolism_Homo sapiens_hsa003801.53193349
21Bile secretion_Homo sapiens_hsa049761.50128371
22Butanoate metabolism_Homo sapiens_hsa006501.45342960
23Carbon metabolism_Homo sapiens_hsa012001.41558315
24Protein digestion and absorption_Homo sapiens_hsa049741.41533150
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40380804
26Fatty acid elongation_Homo sapiens_hsa000621.40119244
27Lysine degradation_Homo sapiens_hsa003101.40027106
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.39466626
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39339539
30Other glycan degradation_Homo sapiens_hsa005111.38476708
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37045555
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34213782
33Tight junction_Homo sapiens_hsa045301.34168199
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33365378
35Fat digestion and absorption_Homo sapiens_hsa049751.27792686
36Endometrial cancer_Homo sapiens_hsa052131.26510628
37Cardiac muscle contraction_Homo sapiens_hsa042601.25946893
38Fructose and mannose metabolism_Homo sapiens_hsa000511.25764314
39Cocaine addiction_Homo sapiens_hsa050301.21735782
40Prion diseases_Homo sapiens_hsa050201.19212153
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18555014
42Pyruvate metabolism_Homo sapiens_hsa006201.18453202
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18304498
44Glioma_Homo sapiens_hsa052141.17245514
45Insulin resistance_Homo sapiens_hsa049311.14201933
46Fatty acid biosynthesis_Homo sapiens_hsa000611.12780576
47Adherens junction_Homo sapiens_hsa045201.12526332
48Melanogenesis_Homo sapiens_hsa049161.12223342
49Dorso-ventral axis formation_Homo sapiens_hsa043201.09884343
50Vitamin B6 metabolism_Homo sapiens_hsa007501.09576144
51ErbB signaling pathway_Homo sapiens_hsa040121.09208353
52Notch signaling pathway_Homo sapiens_hsa043301.09114414
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07486473
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.05318320
55Thyroid cancer_Homo sapiens_hsa052161.01531873
56Arginine and proline metabolism_Homo sapiens_hsa003300.99383610
57Amoebiasis_Homo sapiens_hsa051460.97455977
58mTOR signaling pathway_Homo sapiens_hsa041500.97356534
59Tyrosine metabolism_Homo sapiens_hsa003500.97281901
60Small cell lung cancer_Homo sapiens_hsa052220.95892406
61Galactose metabolism_Homo sapiens_hsa000520.95724564
62Proteoglycans in cancer_Homo sapiens_hsa052050.94171595
63Viral myocarditis_Homo sapiens_hsa054160.93828308
64Pentose phosphate pathway_Homo sapiens_hsa000300.93815802
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93303164
66Caffeine metabolism_Homo sapiens_hsa002320.91555415
67GnRH signaling pathway_Homo sapiens_hsa049120.90160572
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88648991
69beta-Alanine metabolism_Homo sapiens_hsa004100.86020834
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.85559681
71Basal cell carcinoma_Homo sapiens_hsa052170.82824431
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82288045
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81613380
74Amphetamine addiction_Homo sapiens_hsa050310.79135826
75Non-small cell lung cancer_Homo sapiens_hsa052230.78729235
76Sulfur metabolism_Homo sapiens_hsa009200.78724691
77Choline metabolism in cancer_Homo sapiens_hsa052310.78064038
78Hippo signaling pathway_Homo sapiens_hsa043900.77230249
79Renal cell carcinoma_Homo sapiens_hsa052110.77224449
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.77117331
81AMPK signaling pathway_Homo sapiens_hsa041520.76889112
82Starch and sucrose metabolism_Homo sapiens_hsa005000.76163718
83Bladder cancer_Homo sapiens_hsa052190.74880634
84Acute myeloid leukemia_Homo sapiens_hsa052210.73943363
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.73726389
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.73486385
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72893024
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72451924
89Biosynthesis of amino acids_Homo sapiens_hsa012300.71467719
90Peroxisome_Homo sapiens_hsa041460.71154001
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69521426
92Prostate cancer_Homo sapiens_hsa052150.69459007
93Insulin secretion_Homo sapiens_hsa049110.69061118
94Rap1 signaling pathway_Homo sapiens_hsa040150.68558935
95Ovarian steroidogenesis_Homo sapiens_hsa049130.68332104
96cAMP signaling pathway_Homo sapiens_hsa040240.66435896
97Axon guidance_Homo sapiens_hsa043600.65679351
98Inositol phosphate metabolism_Homo sapiens_hsa005620.65265248
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64867884
100Long-term potentiation_Homo sapiens_hsa047200.63990825
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63542324
102Glycerolipid metabolism_Homo sapiens_hsa005610.62926049
103Vibrio cholerae infection_Homo sapiens_hsa051100.61281511
104VEGF signaling pathway_Homo sapiens_hsa043700.61181573
105Hedgehog signaling pathway_Homo sapiens_hsa043400.60404510
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60328141
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59830444
108Wnt signaling pathway_Homo sapiens_hsa043100.59829803
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59192255
110Complement and coagulation cascades_Homo sapiens_hsa046100.59007235
111Insulin signaling pathway_Homo sapiens_hsa049100.58261547
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57398608
113Gastric acid secretion_Homo sapiens_hsa049710.56404106
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55080341
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.54349161
116ABC transporters_Homo sapiens_hsa020100.53049615
117Histidine metabolism_Homo sapiens_hsa003400.52548835
118Vitamin digestion and absorption_Homo sapiens_hsa049770.51460557
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51072762
120MicroRNAs in cancer_Homo sapiens_hsa052060.50140517
121Gap junction_Homo sapiens_hsa045400.49996965
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49029057
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48258732
124Pathways in cancer_Homo sapiens_hsa052000.46085967
125Platelet activation_Homo sapiens_hsa046110.45894367
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45426830
127Glucagon signaling pathway_Homo sapiens_hsa049220.45138507
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.43735121
129Pancreatic secretion_Homo sapiens_hsa049720.42677112
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41735941
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39906362
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38768726
133Estrogen signaling pathway_Homo sapiens_hsa049150.38412969
134Renin secretion_Homo sapiens_hsa049240.37345667
135Chronic myeloid leukemia_Homo sapiens_hsa052200.36617261
136Melanoma_Homo sapiens_hsa052180.36366334
137Thyroid hormone synthesis_Homo sapiens_hsa049180.36158228

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