CASP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.39427783
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16065202
3antigen processing and presentation of endogenous antigen (GO:0019883)4.93858534
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.89798146
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81669412
6negative regulation of cell killing (GO:0031342)4.81669412
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.37076710
8regulation of B cell receptor signaling pathway (GO:0050855)4.32031299
9regulation of gamma-delta T cell activation (GO:0046643)4.11315040
10immunoglobulin mediated immune response (GO:0016064)4.11135334
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00200905
12regulation of gamma-delta T cell differentiation (GO:0045586)3.90566187
13detection of other organism (GO:0098543)3.84088216
14detection of bacterium (GO:0016045)3.74642307
15positive regulation by symbiont of host defense response (GO:0052509)3.61713327
16modulation by symbiont of host defense response (GO:0052031)3.61713327
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61713327
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61713327
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.61713327
20modulation by symbiont of host immune response (GO:0052553)3.61713327
21response to type I interferon (GO:0034340)3.60181382
22cellular response to type I interferon (GO:0071357)3.58132313
23type I interferon signaling pathway (GO:0060337)3.58132313
24negative regulation of interleukin-12 production (GO:0032695)3.53102995
25neutrophil activation involved in immune response (GO:0002283)3.53076232
26macrophage activation involved in immune response (GO:0002281)3.51934388
27negative thymic T cell selection (GO:0045060)3.34597150
28interferon-gamma-mediated signaling pathway (GO:0060333)3.33025817
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.32055384
30regulation of interferon-beta biosynthetic process (GO:0045357)3.30404520
31B cell mediated immunity (GO:0019724)3.29733107
32positive regulation of antigen processing and presentation (GO:0002579)3.29061024
33negative T cell selection (GO:0043383)3.28939130
34cellular extravasation (GO:0045123)3.28684259
35positive thymic T cell selection (GO:0045059)3.26602175
36positive regulation of B cell differentiation (GO:0045579)3.25995087
37regulation of antigen processing and presentation (GO:0002577)3.21767608
38microglial cell activation (GO:0001774)3.19558539
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18479090
40T cell migration (GO:0072678)3.17726791
41B cell receptor signaling pathway (GO:0050853)3.17046575
42response to interleukin-15 (GO:0070672)3.15542414
43regulation of T cell tolerance induction (GO:0002664)3.15059154
44regulation of regulatory T cell differentiation (GO:0045589)3.14034919
45regulation of tolerance induction (GO:0002643)3.09807044
46response to peptidoglycan (GO:0032494)3.08050215
47negative regulation of T cell mediated immunity (GO:0002710)3.05860613
48positive T cell selection (GO:0043368)3.05138985
49regulation of alpha-beta T cell proliferation (GO:0046640)3.03898225
50myeloid cell activation involved in immune response (GO:0002275)3.01807387
51regulation of B cell differentiation (GO:0045577)3.01748838
52neutrophil activation (GO:0042119)3.00975196
53regulation of T cell mediated cytotoxicity (GO:0001914)3.00628838
54mast cell activation (GO:0045576)2.99462914
55detection of external biotic stimulus (GO:0098581)2.99176230
56leukocyte aggregation (GO:0070486)2.98259138
57positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97766511
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96999706
59cellular response to interleukin-15 (GO:0071350)2.94790458
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94709157
61regulation of interferon-alpha production (GO:0032647)2.94372678
62negative regulation of leukocyte mediated immunity (GO:0002704)2.92015088
63positive regulation of tolerance induction (GO:0002645)2.90285221
64regulation of mast cell activation (GO:0033003)2.90255467
65positive regulation of interferon-alpha production (GO:0032727)2.89712047
66interferon-gamma production (GO:0032609)2.87009390
67antigen processing and presentation via MHC class Ib (GO:0002475)2.86317407
68defense response to protozoan (GO:0042832)2.85910174
69response to interferon-beta (GO:0035456)2.85551852
70dendritic cell chemotaxis (GO:0002407)2.83290659
71dendritic cell migration (GO:0036336)2.81617258
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81436327
73regulation of cellular extravasation (GO:0002691)2.81299538
74positive regulation of granulocyte differentiation (GO:0030854)2.79261461
75granulocyte activation (GO:0036230)2.78379015
76T cell selection (GO:0045058)2.77895506
77tolerance induction (GO:0002507)2.77635438
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76195721
79response to host immune response (GO:0052572)2.76195721
80positive regulation of mast cell activation (GO:0033005)2.75777391
81activated T cell proliferation (GO:0050798)2.75560357
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.74773885
83regulation of natural killer cell mediated immunity (GO:0002715)2.74250067
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.74250067
85negative regulation of innate immune response (GO:0045824)2.72688145
86T-helper 1 type immune response (GO:0042088)2.72402444
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.72359208
88positive regulation of interleukin-1 beta secretion (GO:0050718)2.71213286
89respiratory burst (GO:0045730)2.70560956
90cytidine deamination (GO:0009972)2.69447539
91cytidine metabolic process (GO:0046087)2.69447539
92cytidine catabolic process (GO:0006216)2.69447539
93leukocyte degranulation (GO:0043299)2.67462281
94positive regulation of defense response to virus by host (GO:0002230)2.67245522
95regulation of interleukin-1 beta secretion (GO:0050706)2.66875875
96response to protozoan (GO:0001562)2.65164035
97macrophage activation (GO:0042116)2.64163760
98cellular response to exogenous dsRNA (GO:0071360)2.63067787
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.62817150
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62085146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.91540067
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.39326983
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.15184161
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.12308255
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.92181305
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71899766
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93309044
8RUNX_20019798_ChIP-Seq_JUKART_Human2.84688326
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83274636
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.78568085
11SCL_19346495_ChIP-Seq_HPC-7_Human2.61968095
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51529243
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42362791
14MYB_26560356_Chip-Seq_TH2_Human2.38943239
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03682641
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99718623
17SPI1_23547873_ChIP-Seq_NB4_Human1.93618751
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93465198
19MYB_26560356_Chip-Seq_TH1_Human1.92418341
20GATA3_27048872_Chip-Seq_THYMUS_Human1.87023108
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86624766
22* GATA3_26560356_Chip-Seq_TH2_Human1.83402853
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82167059
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81748745
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81305523
26SPI1_23127762_ChIP-Seq_K562_Human1.80148686
27VDR_24787735_ChIP-Seq_THP-1_Human1.77367380
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69618119
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69498113
30* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69158850
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63631143
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60851726
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60755071
34VDR_24763502_ChIP-Seq_THP-1_Human1.59694309
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.57137821
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53639238
37GATA1_22025678_ChIP-Seq_K562_Human1.50805156
38VDR_22108803_ChIP-Seq_LS180_Human1.48905549
39MAF_26560356_Chip-Seq_TH1_Human1.44050582
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37033941
41GATA1_19941826_ChIP-Seq_K562_Human1.34950312
42UTX_26944678_Chip-Seq_JUKART_Human1.32757861
43* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32420173
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32028542
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.29898536
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.29254713
47ZNF274_21170338_ChIP-Seq_K562_Hela1.28414450
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26914539
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23224273
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21077751
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19934905
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19851658
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19310510
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18265252
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18101558
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12669697
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.09395669
58GATA2_19941826_ChIP-Seq_K562_Human1.08954411
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07855506
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.06641838
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05272573
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04239431
63SMRT_27268052_Chip-Seq_Bcells_Human1.02209316
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00891395
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99103850
66MAF_26560356_Chip-Seq_TH2_Human0.97366180
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97310894
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97156060
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96816536
70VDR_21846776_ChIP-Seq_THP-1_Human0.95587783
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.94636764
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94161044
73PU_27001747_Chip-Seq_BMDM_Mouse0.93924392
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92796539
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.91073293
76CEBPB_22108803_ChIP-Seq_LS180_Human0.89997117
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89817050
78GATA3_26560356_Chip-Seq_TH1_Human0.88800486
79STAT1_20625510_ChIP-Seq_HELA_Human0.88694384
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.87738687
81NANOG_20526341_ChIP-Seq_ESCs_Human0.86257067
82PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86092933
83BCL6_27268052_Chip-Seq_Bcells_Human0.85612493
84BCAT_22108803_ChIP-Seq_LS180_Human0.85464528
85P300_27268052_Chip-Seq_Bcells_Human0.84842177
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84602664
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84415261
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83738808
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81506527
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78427970
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78000599
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77899853
93BCOR_27268052_Chip-Seq_Bcells_Human0.77733533
94AR_20517297_ChIP-Seq_VCAP_Human0.77259789
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76845730
96IRF1_19129219_ChIP-ChIP_H3396_Human0.76526208
97GATA4_25053715_ChIP-Seq_YYC3_Human0.76243740
98ER_23166858_ChIP-Seq_MCF-7_Human0.76171681
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75807810
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75059776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.29427390
2MP0001835_abnormal_antigen_presentation3.64738285
3MP0005671_abnormal_response_to3.39492009
4MP0003436_decreased_susceptibility_to3.17237378
5MP0003303_peritoneal_inflammation3.15276359
6MP0006082_CNS_inflammation3.04706125
7MP0001800_abnormal_humoral_immune2.89528992
8MP0009785_altered_susceptibility_to2.89320950
9MP0005387_immune_system_phenotype2.72311627
10MP0001790_abnormal_immune_system2.72311627
11MP0005025_abnormal_response_to2.67445034
12MP0005000_abnormal_immune_tolerance2.61964944
13MP0000685_abnormal_immune_system2.54036912
14MP0002419_abnormal_innate_immunity2.51551905
15MP0002723_abnormal_immune_serum2.49273079
16MP0002148_abnormal_hypersensitivity_rea2.43878483
17MP0002452_abnormal_antigen_presenting2.40484220
18MP0002420_abnormal_adaptive_immunity2.32099727
19MP0001819_abnormal_immune_cell2.31309280
20MP0003763_abnormal_thymus_physiology2.29512030
21MP0010155_abnormal_intestine_physiology2.28196433
22MP0005464_abnormal_platelet_physiology1.95487838
23MP0009333_abnormal_splenocyte_physiolog1.94125976
24MP0002405_respiratory_system_inflammati1.90342329
25MP0009764_decreased_sensitivity_to1.89474852
26MP0008004_abnormal_stomach_pH1.83997931
27MP0001845_abnormal_inflammatory_respons1.81719539
28MP0000716_abnormal_immune_system1.80422843
29MP0001873_stomach_inflammation1.79975088
30MP0002138_abnormal_hepatobiliary_system1.79906372
31MP0003866_abnormal_defecation1.79778479
32MP0003183_abnormal_peptide_metabolism1.78615905
33MP0003300_gastrointestinal_ulcer1.77135992
34MP0002398_abnormal_bone_marrow1.76739194
35MP0001533_abnormal_skeleton_physiology1.67234375
36MP0000465_gastrointestinal_hemorrhage1.60084860
37MP0003195_calcinosis1.57872312
38MP0000689_abnormal_spleen_morphology1.54474295
39MP0005310_abnormal_salivary_gland1.52512531
40MP0008469_abnormal_protein_level1.51008066
41MP0002722_abnormal_immune_system1.46201938
42MP0005085_abnormal_gallbladder_physiolo1.43054219
43MP0002429_abnormal_blood_cell1.41220835
44MP0005360_urolithiasis1.34681562
45MP0004947_skin_inflammation1.32869213
46MP0002132_abnormal_respiratory_system1.31094666
47MP0002396_abnormal_hematopoietic_system1.30694347
48MP0001986_abnormal_taste_sensitivity1.29735220
49MP0001663_abnormal_digestive_system1.28785502
50MP0000703_abnormal_thymus_morphology1.18976061
51MP0005397_hematopoietic_system_phenotyp1.16172134
52MP0001545_abnormal_hematopoietic_system1.16172134
53MP0003828_pulmonary_edema1.15764024
54MP0002166_altered_tumor_susceptibility1.13975912
55MP0000569_abnormal_digit_pigmentation1.11583243
56MP0003172_abnormal_lysosome_physiology1.10426046
57MP0003646_muscle_fatigue1.09689346
58MP0005365_abnormal_bile_salt1.09470120
59MP0003252_abnormal_bile_duct1.06210733
60MP0009278_abnormal_bone_marrow1.03193313
61MP0003191_abnormal_cellular_cholesterol1.01915891
62MP0005166_decreased_susceptibility_to1.00054596
63MP0003806_abnormal_nucleotide_metabolis0.98879411
64MP0002277_abnormal_respiratory_mucosa0.98766510
65MP0002933_joint_inflammation0.98181656
66MP0005167_abnormal_blood-brain_barrier0.95888230
67MP0004883_abnormal_blood_vessel0.95710824
68MP0002139_abnormal_hepatobiliary_system0.92428425
69MP0001501_abnormal_sleep_pattern0.89917603
70MP0003656_abnormal_erythrocyte_physiolo0.89126754
71MP0006054_spinal_hemorrhage0.87104590
72MP0002876_abnormal_thyroid_physiology0.86773993
73MP0002998_abnormal_bone_remodeling0.86655758
74MP0003075_altered_response_to0.85905245
75MP0005174_abnormal_tail_pigmentation0.84241361
76MP0009763_increased_sensitivity_to0.82779851
77MP0001853_heart_inflammation0.82245085
78MP0004043_abnormal_pH_regulation0.81997781
79MP0001851_eye_inflammation0.80764842
80MP0002006_tumorigenesis0.80426639
81MP0004147_increased_porphyrin_level0.80424518
82MP0009840_abnormal_foam_cell0.78563277
83MP0002254_reproductive_system_inflammat0.77761523
84MP0009765_abnormal_xenobiotic_induced0.77516723
85MP0000249_abnormal_blood_vessel0.77336456
86MP0010329_abnormal_lipoprotein_level0.76667789
87MP0008875_abnormal_xenobiotic_pharmacok0.76572920
88MP0001666_abnormal_nutrient_absorption0.76468303
89MP0005164_abnormal_response_to0.74761645
90MP0001764_abnormal_homeostasis0.72737359
91MP0005319_abnormal_enzyme/_coenzyme0.71886360
92MP0005381_digestive/alimentary_phenotyp0.71026493
93MP0000858_altered_metastatic_potential0.70876836
94MP0000015_abnormal_ear_pigmentation0.70391858
95MP0009643_abnormal_urine_homeostasis0.68880321
96MP0002693_abnormal_pancreas_physiology0.68540615
97MP0008872_abnormal_physiological_respon0.68485322
98MP0001765_abnormal_ion_homeostasis0.68172257
99MP0008995_early_reproductive_senescence0.67361850
100MP0002136_abnormal_kidney_physiology0.67300374

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.81669179
2Eczematoid dermatitis (HP:0000976)4.65684569
3Retrobulbar optic neuritis (HP:0100654)4.63559310
4Optic neuritis (HP:0100653)4.63559310
5Stomatitis (HP:0010280)4.57680558
6Orchitis (HP:0100796)4.57006409
7Recurrent bacterial skin infections (HP:0005406)4.37319855
8Elevated erythrocyte sedimentation rate (HP:0003565)4.26190793
9Recurrent abscess formation (HP:0002722)4.21917699
10Recurrent fungal infections (HP:0002841)4.01545497
11Abnormality of macrophages (HP:0004311)3.74687555
12Pustule (HP:0200039)3.63460657
13Gastrointestinal infarctions (HP:0005244)3.50702740
14Encephalitis (HP:0002383)3.47694318
15Chronic mucocutaneous candidiasis (HP:0002728)3.45945640
16Recurrent cutaneous fungal infections (HP:0011370)3.45945640
17T lymphocytopenia (HP:0005403)3.43756329
18Keratoconjunctivitis (HP:0001096)3.43309014
19Meningitis (HP:0001287)3.42737243
20Keratoconjunctivitis sicca (HP:0001097)3.34471185
21* Abnormal delayed hypersensitivity skin test (HP:0002963)3.33473306
22Recurrent skin infections (HP:0001581)3.30433058
23Recurrent gram-negative bacterial infections (HP:0005420)3.29608620
24* Vasculitis (HP:0002633)3.26733537
25Hemoptysis (HP:0002105)3.23839216
26Mediastinal lymphadenopathy (HP:0100721)3.23357462
27Chronic obstructive pulmonary disease (HP:0006510)3.19265220
28Obstructive lung disease (HP:0006536)3.19265220
29* Abnormality of T cell number (HP:0011839)3.16317874
30Pulmonary infiltrates (HP:0002113)3.10436336
31* Abnormality of T cells (HP:0002843)3.02519552
32Panhypogammaglobulinemia (HP:0003139)2.94134034
33Chronic diarrhea (HP:0002028)2.93361151
34Prolonged bleeding time (HP:0003010)2.91245320
35Spontaneous hematomas (HP:0007420)2.89698400
36Recurrent viral infections (HP:0004429)2.88688892
37Chest pain (HP:0100749)2.61076950
38Agammaglobulinemia (HP:0004432)2.59305493
39Pulmonary embolism (HP:0002204)2.59189610
40* Leukocytosis (HP:0001974)2.56544750
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.56082385
42Epistaxis (HP:0000421)2.55589225
43Gangrene (HP:0100758)2.53960188
44Anorexia (HP:0002039)2.51053012
45* Abnormality of T cell physiology (HP:0011840)2.49253193
46Hematochezia (HP:0002573)2.49122216
47Arterial thrombosis (HP:0004420)2.48426618
48* Stomach cancer (HP:0012126)2.47593516
49Increased cerebral lipofuscin (HP:0011813)2.46776357
50Increased IgE level (HP:0003212)2.45949365
51Gingival bleeding (HP:0000225)2.45669532
52Abnormality of the prostate (HP:0008775)2.43657835
53Recurrent bronchitis (HP:0002837)2.37893868
54Abnormality of the pleura (HP:0002103)2.37164771
55Inflammation of the large intestine (HP:0002037)2.34583156
56Gingivitis (HP:0000230)2.31764588
57Decreased circulating renin level (HP:0003351)2.31037574
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30073364
59Joint swelling (HP:0001386)2.29369756
60IgG deficiency (HP:0004315)2.26906012
61Chronic otitis media (HP:0000389)2.22385678
62* Urticaria (HP:0001025)2.17545983
63IgM deficiency (HP:0002850)2.16508839
64Abnormality of transition element cation homeostasis (HP:0011030)2.15071811
65Gastrointestinal inflammation (HP:0004386)2.12164738
66Systemic lupus erythematosus (HP:0002725)2.07943011
67Lymphopenia (HP:0001888)2.07255161
68Alveolar cell carcinoma (HP:0006519)2.03947658
69Abnormality of iron homeostasis (HP:0011031)2.03541403
70* Autoimmune thrombocytopenia (HP:0001973)2.02852396
71Episodic fever (HP:0001954)2.02842119
72Colitis (HP:0002583)2.02636838
73* Eosinophilia (HP:0001880)2.01579719
74Polyneuropathy (HP:0001271)2.00760007
75* Granulocytopenia (HP:0001913)2.00303006
76Petechiae (HP:0000967)1.99844849
77* Autoimmune hemolytic anemia (HP:0001890)1.99362798
78Skin rash (HP:0000988)1.98065766
79Neoplasm of the tracheobronchial system (HP:0100552)1.97069917
80Amyloidosis (HP:0011034)1.92597964
81Osteomyelitis (HP:0002754)1.91426601
82Severe combined immunodeficiency (HP:0004430)1.90961947
83* Abnormality of eosinophils (HP:0001879)1.90838877
84Malnutrition (HP:0004395)1.89740390
85Vertigo (HP:0002321)1.89514044
86Congenital stationary night blindness (HP:0007642)1.89114683
87Increased serum ferritin (HP:0003281)1.88919502
88Amaurosis fugax (HP:0100576)1.87960764
89Thrombophlebitis (HP:0004418)1.87480176
90Vacuolated lymphocytes (HP:0001922)1.86366475
91Hypochromic microcytic anemia (HP:0004840)1.85664060
92Acute hepatic failure (HP:0006554)1.84792083
93Microcytic anemia (HP:0001935)1.83841449
94Prostate neoplasm (HP:0100787)1.81070382
95Keratitis (HP:0000491)1.80470179
96* Abnormality of cells of the lymphoid lineage (HP:0012140)1.80384133
97Abnormality of the renal cortex (HP:0011035)1.80016983
98Attenuation of retinal blood vessels (HP:0007843)1.79504619
99Thyroiditis (HP:0100646)1.79330461
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79098826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.09425550
2TXK4.00400713
3MAP4K13.98319576
4FRK3.11186592
5RIPK42.98696748
6BLK2.69875479
7ACVR1B2.57134472
8TYK22.44543810
9IRAK42.29230875
10MAP3K142.25480624
11FES2.25336214
12IKBKE2.09498929
13ITK2.07753579
14CSK2.02825144
15TEC2.01672925
16SYK2.00961851
17JAK32.00768738
18BTK1.93091542
19GRK61.91311917
20ZAP701.88148789
21KIT1.81994210
22ADRBK21.60684644
23TBK11.57215028
24IKBKB1.56593812
25TNK21.51615227
26MAP3K131.47907201
27LYN1.44664806
28JAK11.43881801
29ERN11.40553693
30LCK1.38542264
31HCK1.38228731
32MAP2K31.36873015
33TIE11.26805790
34MATK1.22076175
35PIK3CG1.18215244
36FGR1.17856729
37JAK21.13914063
38BMPR21.13619306
39IRAK11.13127233
40CSF1R1.09570619
41TLK11.09040403
42CAMKK21.08034052
43BMPR1B1.07539662
44PRKCQ0.97145731
45NLK0.94676444
46GRK70.89465106
47FGFR30.86346321
48PIM10.83423569
49TGFBR20.83192136
50GRK10.80597544
51MAP3K110.74882691
52DAPK20.74712546
53PINK10.74449344
54MAP2K60.74308766
55PRPF4B0.74112025
56MARK30.73945049
57ZAK0.73753473
58MAP3K30.71001109
59CAMKK10.69982604
60PDK10.69173376
61PIK3CA0.68701683
62NUAK10.67889493
63INSRR0.67088643
64KDR0.66869543
65MAP3K70.65973137
66PRKAA20.65154548
67PTK2B0.61301748
68EPHA30.61007114
69TAOK10.58404653
70MAP3K10.54153360
71TESK20.54045102
72OXSR10.53769115
73EPHB10.51139322
74CHUK0.50038798
75STK100.49185034
76MAPK70.48673687
77ADRBK10.48339373
78TRPM70.48184254
79PASK0.46101130
80MAPK110.46012067
81HIPK20.45262126
82MAP2K20.44485910
83CDC42BPA0.42495523
84FYN0.41797766
85PDPK10.41192890
86PRKG20.40407544
87IGF1R0.39561474
88FGFR40.39326675
89YES10.38905828
90MAPK120.38459129
91ABL10.33015300
92EGFR0.30169611
93SIK30.29882210
94SGK20.26710142
95TGFBR10.26670515
96STK110.25380428
97MAPK30.24214759
98MAP3K50.24121156
99MAP3K20.23971531
100PRKCD0.22677896

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.58188045
2Allograft rejection_Homo sapiens_hsa053303.46612197
3Autoimmune thyroid disease_Homo sapiens_hsa053203.26228107
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.11642616
5Staphylococcus aureus infection_Homo sapiens_hsa051503.06855764
6Asthma_Homo sapiens_hsa053103.03658622
7Primary immunodeficiency_Homo sapiens_hsa053402.65305314
8Leishmaniasis_Homo sapiens_hsa051402.63484684
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59835772
10Type I diabetes mellitus_Homo sapiens_hsa049402.54040933
11Antigen processing and presentation_Homo sapiens_hsa046122.07287313
12Osteoclast differentiation_Homo sapiens_hsa043802.03900712
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94479941
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89975756
15Hematopoietic cell lineage_Homo sapiens_hsa046401.89463815
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.82753025
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62530716
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60157928
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58422503
20* Tuberculosis_Homo sapiens_hsa051521.56793665
21* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54389152
22B cell receptor signaling pathway_Homo sapiens_hsa046621.53741103
23Rheumatoid arthritis_Homo sapiens_hsa053231.51963419
24T cell receptor signaling pathway_Homo sapiens_hsa046601.47366799
25Viral myocarditis_Homo sapiens_hsa054161.45016171
26Measles_Homo sapiens_hsa051621.38963192
27Influenza A_Homo sapiens_hsa051641.38355081
28Linoleic acid metabolism_Homo sapiens_hsa005911.33731684
29Malaria_Homo sapiens_hsa051441.33304814
30Herpes simplex infection_Homo sapiens_hsa051681.28983986
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.28349774
32African trypanosomiasis_Homo sapiens_hsa051431.28302490
33Toxoplasmosis_Homo sapiens_hsa051451.27941032
34Chemokine signaling pathway_Homo sapiens_hsa040621.23538524
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21042698
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15730697
37* TNF signaling pathway_Homo sapiens_hsa046681.15103352
38Pertussis_Homo sapiens_hsa051331.13341599
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12346933
40Caffeine metabolism_Homo sapiens_hsa002321.06015109
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04703760
42Legionellosis_Homo sapiens_hsa051341.02695649
43Fat digestion and absorption_Homo sapiens_hsa049750.99774117
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99190678
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98321205
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97812410
47Platelet activation_Homo sapiens_hsa046110.97620296
48Ether lipid metabolism_Homo sapiens_hsa005650.95902671
49Arachidonic acid metabolism_Homo sapiens_hsa005900.94184893
50Vitamin digestion and absorption_Homo sapiens_hsa049770.92891408
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89001354
52Glycerolipid metabolism_Homo sapiens_hsa005610.83760647
53Acute myeloid leukemia_Homo sapiens_hsa052210.82760827
54Hepatitis C_Homo sapiens_hsa051600.81801421
55Other glycan degradation_Homo sapiens_hsa005110.79913619
56Nitrogen metabolism_Homo sapiens_hsa009100.78050345
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75716614
58ABC transporters_Homo sapiens_hsa020100.71084060
59Phagosome_Homo sapiens_hsa041450.65910835
60Tryptophan metabolism_Homo sapiens_hsa003800.65749515
61Dorso-ventral axis formation_Homo sapiens_hsa043200.63850023
62Lysosome_Homo sapiens_hsa041420.62031787
63Chemical carcinogenesis_Homo sapiens_hsa052040.61502637
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61134439
65Complement and coagulation cascades_Homo sapiens_hsa046100.59364467
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.59331144
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58024253
68Retinol metabolism_Homo sapiens_hsa008300.56494221
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.56485457
70Systemic lupus erythematosus_Homo sapiens_hsa053220.55257705
71Renin-angiotensin system_Homo sapiens_hsa046140.55243381
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52482557
73* Hepatitis B_Homo sapiens_hsa051610.50384188
74* Apoptosis_Homo sapiens_hsa042100.46685525
75Histidine metabolism_Homo sapiens_hsa003400.44557950
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.44531160
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.42183244
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.40884525
79Mineral absorption_Homo sapiens_hsa049780.39633191
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.39599027
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.39577400
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38823673
83Epstein-Barr virus infection_Homo sapiens_hsa051690.37593085
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36394508
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36245492
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36036900
87Peroxisome_Homo sapiens_hsa041460.35512731
88Prolactin signaling pathway_Homo sapiens_hsa049170.33937861
89Insulin resistance_Homo sapiens_hsa049310.33444677
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32976907
91Sulfur metabolism_Homo sapiens_hsa009200.32877164
92Salmonella infection_Homo sapiens_hsa051320.32868551
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31846600
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.27460101
95Pancreatic secretion_Homo sapiens_hsa049720.26742665
96Starch and sucrose metabolism_Homo sapiens_hsa005000.25960555
97Regulation of autophagy_Homo sapiens_hsa041400.25853648
98PPAR signaling pathway_Homo sapiens_hsa033200.23428037
99FoxO signaling pathway_Homo sapiens_hsa040680.22869226
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21591693

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