CASP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.42750119
2keratinocyte differentiation (GO:0030216)9.09891941
3multicellular organismal water homeostasis (GO:0050891)8.84407431
4peptide cross-linking (GO:0018149)8.22723887
5intermediate filament organization (GO:0045109)7.84250089
6water homeostasis (GO:0030104)7.37138000
7epidermal cell differentiation (GO:0009913)7.10128853
8bundle of His cell to Purkinje myocyte communication (GO:0086069)7.00123095
9skin morphogenesis (GO:0043589)6.81140562
10fatty acid elongation (GO:0030497)6.55166686
11* epidermis development (GO:0008544)6.28945474
12keratinocyte proliferation (GO:0043616)5.76573448
13ectoderm development (GO:0007398)5.76523949
14detection of bacterium (GO:0016045)5.72019224
15long-chain fatty acid biosynthetic process (GO:0042759)5.67674929
16sphingoid metabolic process (GO:0046519)5.24228698
17intermediate filament cytoskeleton organization (GO:0045104)5.20259454
18intermediate filament-based process (GO:0045103)5.11413663
19gap junction assembly (GO:0016264)5.05783910
20detection of other organism (GO:0098543)4.87287417
21keratinocyte development (GO:0003334)4.85214850
22sphingosine metabolic process (GO:0006670)4.65795708
23regulation of ruffle assembly (GO:1900027)4.65439831
24lateral sprouting from an epithelium (GO:0060601)4.46256229
25diol metabolic process (GO:0034311)4.34194702
26polarized epithelial cell differentiation (GO:0030859)4.31717093
27glucosamine-containing compound catabolic process (GO:1901072)4.17527932
28positive regulation of T cell chemotaxis (GO:0010820)4.09130426
29regulation of T cell chemotaxis (GO:0010819)4.09130426
30long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.96840438
31phosphatidylinositol acyl-chain remodeling (GO:0036149)3.91098373
32adhesion of symbiont to host cell (GO:0044650)3.88954758
33virion attachment to host cell (GO:0019062)3.88954758
34sequestering of metal ion (GO:0051238)3.85626582
35ceramide biosynthetic process (GO:0046513)3.85290459
36linoleic acid metabolic process (GO:0043651)3.80694186
37regulation of keratinocyte proliferation (GO:0010837)3.79628964
38phosphatidylserine metabolic process (GO:0006658)3.75656293
39regulation of phospholipase A2 activity (GO:0032429)3.71100032
40regulation of hypersensitivity (GO:0002883)3.57731549
41atrioventricular valve morphogenesis (GO:0003181)3.55740662
42phospholipid efflux (GO:0033700)3.54940365
43regulation of natural killer cell differentiation (GO:0032823)3.53035261
44skin development (GO:0043588)3.50016101
45negative regulation of keratinocyte proliferation (GO:0010839)3.47430860
46phosphatidylserine acyl-chain remodeling (GO:0036150)3.45661350
47negative regulation of interferon-gamma production (GO:0032689)3.45014502
48regulation of keratinocyte differentiation (GO:0045616)3.41847898
49negative regulation of interleukin-17 production (GO:0032700)3.41635288
50regulation of cell proliferation involved in kidney development (GO:1901722)3.37588371
51positive regulation of cholesterol efflux (GO:0010875)3.31215970
52lipoxygenase pathway (GO:0019372)3.30972997
53detection of external biotic stimulus (GO:0098581)3.30009490
54cell-substrate junction assembly (GO:0007044)3.27171118
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.26832576
56eyelid development in camera-type eye (GO:0061029)3.24964550
57establishment of tissue polarity (GO:0007164)3.24790683
58establishment of planar polarity (GO:0001736)3.24790683
59fatty-acyl-CoA metabolic process (GO:0035337)3.24790105
60hair follicle morphogenesis (GO:0031069)3.22123997
61epithelial cell differentiation involved in prostate gland development (GO:0060742)3.21233942
62phospholipid catabolic process (GO:0009395)3.15102901
63planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13222463
64regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.12389577
65negative regulation of stress fiber assembly (GO:0051497)3.07580691
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.05254387
67positive regulation of interleukin-8 secretion (GO:2000484)3.03596736
68epithelial cell-cell adhesion (GO:0090136)3.03317918
69adhesion of symbiont to host (GO:0044406)3.02592294
70positive regulation of epidermis development (GO:0045684)3.01581038
71alditol phosphate metabolic process (GO:0052646)3.00454889
72negative regulation of cell fate specification (GO:0009996)2.99759026
73positive regulation of sterol transport (GO:0032373)2.99295219
74positive regulation of cholesterol transport (GO:0032376)2.99295219
75interferon-gamma secretion (GO:0072643)2.98360757
76cyclooxygenase pathway (GO:0019371)2.96864524
77fatty-acyl-CoA biosynthetic process (GO:0046949)2.95913360
78regulation of monocyte chemotaxis (GO:0090025)2.95752916
79* epithelium development (GO:0060429)2.94572756
80one-carbon compound transport (GO:0019755)2.93959815
81regulation of natural killer cell activation (GO:0032814)2.93763698
82regulation of protein localization to cell surface (GO:2000008)2.91906863
83positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.89711500
84phospholipid scrambling (GO:0017121)2.88425578
85primary alcohol catabolic process (GO:0034310)2.86920684
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86073095
87prostaglandin biosynthetic process (GO:0001516)2.84408758
88prostanoid biosynthetic process (GO:0046457)2.84408758
89detection of biotic stimulus (GO:0009595)2.82608457
90regulation of transforming growth factor beta1 production (GO:0032908)2.82475244
91gland morphogenesis (GO:0022612)2.79387297
92ventricular cardiac muscle cell action potential (GO:0086005)2.79160398
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77882539
94regulation of chemokine secretion (GO:0090196)2.77576704
95negative regulation of acute inflammatory response (GO:0002674)2.77497863
96positive regulation of hair cycle (GO:0042635)2.76607193
97positive regulation of hair follicle development (GO:0051798)2.76607193
98sphingolipid biosynthetic process (GO:0030148)2.76532184
99cardiac right ventricle morphogenesis (GO:0003215)2.74743975
100very long-chain fatty acid metabolic process (GO:0000038)2.73143808
101positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.68841911
102fibrinolysis (GO:0042730)2.68816865
103phosphatidylcholine acyl-chain remodeling (GO:0036151)2.65262227
104phosphatidylglycerol metabolic process (GO:0046471)2.65014140
105defense response to fungus (GO:0050832)2.64966325
106chemical homeostasis within a tissue (GO:0048875)2.64102824
107positive regulation of monocyte chemotaxis (GO:0090026)2.61819267
108intestinal epithelial cell development (GO:0060576)2.59550073
109regulation of epidermal cell differentiation (GO:0045604)2.59023308
110negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.58920239
111regulation of cardioblast differentiation (GO:0051890)2.57598896
112viral transcription (GO:0019083)2.56676918
113protein localization to endosome (GO:0036010)2.54204098
114positive regulation of epidermal cell differentiation (GO:0045606)2.53282756
115regulation of interleukin-8 secretion (GO:2000482)2.49530813
116positive regulation of interleukin-4 production (GO:0032753)2.48666112
117prostanoid metabolic process (GO:0006692)2.47848823
118prostaglandin metabolic process (GO:0006693)2.47848823
119negative regulation of interleukin-2 production (GO:0032703)2.47064833
120hair cycle process (GO:0022405)2.46145081
121molting cycle process (GO:0022404)2.46145081
122positive regulation of glomerulus development (GO:0090193)2.45814561
123regulation of neuron projection regeneration (GO:0070570)2.45299133
124regulation of axon regeneration (GO:0048679)2.45299133
125surfactant homeostasis (GO:0043129)2.44393294
126polyol transport (GO:0015791)2.43890517
127negative regulation of epidermal cell differentiation (GO:0045605)2.43652624
128regulation of hair follicle development (GO:0051797)2.43162930
129negative regulation of epidermis development (GO:0045683)2.41239612
130epithelial cell differentiation (GO:0030855)2.40380935
131regulation of heart rate by cardiac conduction (GO:0086091)2.39838339
132regulation of epidermis development (GO:0045682)2.39422038
133genitalia morphogenesis (GO:0035112)2.39266199
134regulation of lymphocyte chemotaxis (GO:1901623)2.36524432
135cell communication involved in cardiac conduction (GO:0086065)2.27117930
136magnesium ion transport (GO:0015693)2.26675026
137cardiac conduction (GO:0061337)2.23884256
138negative regulation of cell aging (GO:0090344)2.23510347
139positive regulation of granulocyte chemotaxis (GO:0071624)2.21934733
140membrane lipid biosynthetic process (GO:0046467)2.21830625
141sympathetic nervous system development (GO:0048485)2.19464240
142negative regulation of lymphocyte differentiation (GO:0045620)2.18438709
143unsaturated fatty acid biosynthetic process (GO:0006636)2.17785332
144epithelial cell proliferation (GO:0050673)2.16200623
145regulation of cholesterol efflux (GO:0010874)2.14251662
146* keratinization (GO:0031424)16.7171225
147desmosome organization (GO:0002934)15.2133020
148establishment of skin barrier (GO:0061436)14.9122488
149regulation of water loss via skin (GO:0033561)13.3053488
150molting cycle (GO:0042303)12.5152336
151hair cycle (GO:0042633)12.5152336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.10004091
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.29291728
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17097319
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.58039029
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33688569
6ZNF263_19887448_ChIP-Seq_K562_Human2.21274102
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.11228458
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.08609985
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.05234886
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.05234886
11TP63_17297297_ChIP-ChIP_HaCaT_Human16.4195092
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.84238710
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80236519
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.74226285
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73367374
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51724342
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46322193
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.45747078
19TP63_23658742_ChIP-Seq_EP156T_Human1.45046873
20SOX2_20726797_ChIP-Seq_SW620_Human1.40271318
21TP63_22573176_ChIP-Seq_HFKS_Human1.39222858
22ATF3_27146783_Chip-Seq_COLON_Human1.36467077
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34512242
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31951428
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30634704
26GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.30393593
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29345712
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25727212
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25383570
30KLF5_25053715_ChIP-Seq_YYC3_Human1.23539224
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.23293341
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.23125630
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.22430000
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20965699
35CJUN_26792858_Chip-Seq_BT549_Human1.19643077
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19050777
37SMAD4_21799915_ChIP-Seq_A2780_Human1.17168596
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14564917
39RXR_22108803_ChIP-Seq_LS180_Human1.14046910
40GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.12503158
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11706548
42GATA6_21074721_ChIP-Seq_CACO-2_Human1.11040087
43* GATA3_24758297_ChIP-Seq_MCF-7_Human1.09643373
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08021988
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07897511
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07382461
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07365054
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06898538
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06376142
50P53_21459846_ChIP-Seq_SAOS-2_Human1.04515293
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04303455
52CTCF_27219007_Chip-Seq_Bcells_Human1.03706889
53TP53_18474530_ChIP-ChIP_U2OS_Human1.02931343
54GATA4_25053715_ChIP-Seq_YYC3_Human1.02055672
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01999905
56AR_25329375_ChIP-Seq_VCAP_Human1.01284308
57* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01056067
58EGR1_19032775_ChIP-ChIP_M12_Human1.01005450
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.00925320
60CDX2_22108803_ChIP-Seq_LS180_Human0.99671009
61UBF1/2_26484160_Chip-Seq_HMECs_Human0.99506692
62NCOR_22424771_ChIP-Seq_293T_Human0.99445463
63AR_21572438_ChIP-Seq_LNCaP_Human0.98936875
64CTCF_20526341_ChIP-Seq_ESCs_Human0.98890117
65CEBPB_22108803_ChIP-Seq_LS180_Human0.98762242
66* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98209594
67LXR_22292898_ChIP-Seq_THP-1_Human0.96472687
68HTT_18923047_ChIP-ChIP_STHdh_Human0.95663733
69FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95213290
70POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93160305
71SA1_27219007_Chip-Seq_ERYTHROID_Human0.92400233
72VDR_22108803_ChIP-Seq_LS180_Human0.91869628
73YY1_22570637_ChIP-Seq_MALME-3M_Human0.91869081
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90346185
75GATA6_25053715_ChIP-Seq_YYC3_Human0.89730646
76SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88715681
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88636795
78DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88360466
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87236961
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87236961
81* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87174662
82ETV1_20927104_ChIP-Seq_GIST48_Human0.86608744
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85586474
84* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85416535
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84867652
86BCOR_27268052_Chip-Seq_Bcells_Human0.84429077
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84063378
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.82752273
89CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82582753
90BCAT_22108803_ChIP-Seq_LS180_Human0.82544388
91CBX2_22325352_ChIP-Seq_293T-Rex_Human0.81783229
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81528427
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81348011
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81285191
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.81111958
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81099961
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80474071
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80474071
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80411215
100AHR_22903824_ChIP-Seq_MCF-7_Human0.80226345
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79279781
102NANOG_20526341_ChIP-Seq_ESCs_Human0.78997227
103GATA1_22025678_ChIP-Seq_K562_Human0.78348319
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.77863570
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.77286836
106FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77286836
107TP53_16413492_ChIP-PET_HCT116_Human0.76733021
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76607211
109AR_20517297_ChIP-Seq_VCAP_Human0.76342655
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.75250457
111* E2F1_20622854_ChIP-Seq_HELA_Human0.75219412
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.74182498
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74155519
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.73995766
115TBL1_22424771_ChIP-Seq_293T_Human0.73888513
116EZH2_27304074_Chip-Seq_ESCs_Mouse0.73603243
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.73316501
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73221573
119P68_20966046_ChIP-Seq_HELA_Human0.72783612
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72212037
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72177847
122JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70219240
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68545424
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.67391824
125TAF2_19829295_ChIP-Seq_ESCs_Human0.66865818
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.65397058
127CLOCK_20551151_ChIP-Seq_293T_Human0.64562933
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.64169039
129HNFA_21074721_ChIP-Seq_CACO-2_Human0.64132674
130SA1_27219007_Chip-Seq_Bcells_Human0.63522005
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63210303
132KDM2B_26808549_Chip-Seq_K562_Human0.62559385
133RBPJ_21746931_ChIP-Seq_IB4_Human0.61643898
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.61167685
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.60798294
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60256431
137BCL6_27268052_Chip-Seq_Bcells_Human0.59575154
138TCF4_22108803_ChIP-Seq_LS180_Human0.59287003
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57974865
140ERG_20517297_ChIP-Seq_VCAP_Human0.57237351
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.56199596
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.56150330
143RNF2_27304074_Chip-Seq_ESCs_Mouse0.55856243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier8.17480253
2MP0005275_abnormal_skin_tensile6.78106348
3MP0010234_abnormal_vibrissa_follicle5.32480140
4MP0000579_abnormal_nail_morphology5.21092638
5* MP0005501_abnormal_skin_physiology4.97791415
6MP0004381_abnormal_hair_follicle4.14835674
7MP0003941_abnormal_skin_development3.63232725
8MP0002060_abnormal_skin_morphology3.55078539
9* MP0001216_abnormal_epidermal_layer3.46382996
10MP0000383_abnormal_hair_follicle3.34080665
11MP0010678_abnormal_skin_adnexa3.25633965
12MP0004885_abnormal_endolymph3.17294542
13MP0005451_abnormal_body_composition3.11548204
14* MP0010771_integument_phenotype3.09064915
15MP0002254_reproductive_system_inflammat3.04290329
16MP0000647_abnormal_sebaceous_gland3.03320468
17MP0002098_abnormal_vibrissa_morphology2.89262855
18MP0003705_abnormal_hypodermis_morpholog2.88801431
19MP0000467_abnormal_esophagus_morphology2.86896351
20MP0004947_skin_inflammation2.81522226
21MP0003453_abnormal_keratinocyte_physiol2.67872889
22MP0000377_abnormal_hair_follicle2.58661283
23MP0005377_hearing/vestibular/ear_phenot2.53566445
24MP0003878_abnormal_ear_physiology2.53566445
25MP0000427_abnormal_hair_cycle2.37212352
26MP0000762_abnormal_tongue_morphology2.00521719
27MP0003566_abnormal_cell_adhesion1.83113651
28* MP0009931_abnormal_skin_appearance1.68360103
29MP0001243_abnormal_dermal_layer1.60126694
30MP0004185_abnormal_adipocyte_glucose1.55932589
31* MP0001191_abnormal_skin_condition1.54252166
32MP0000367_abnormal_coat/_hair1.47498979
33MP0001346_abnormal_lacrimal_gland1.44151199
34MP0005409_darkened_coat_color1.25904954
35MP0003191_abnormal_cellular_cholesterol1.19581437
36MP0002234_abnormal_pharynx_morphology1.17664219
37MP0000015_abnormal_ear_pigmentation1.17062849
38MP0009379_abnormal_foot_pigmentation1.14172578
39MP0000566_synostosis1.13617031
40MP0005174_abnormal_tail_pigmentation1.11682291
41MP0009053_abnormal_anal_canal0.99292325
42MP0001188_hyperpigmentation0.98896453
43MP0005023_abnormal_wound_healing0.95233183
44MP0001851_eye_inflammation0.92218536
45MP0010352_gastrointestinal_tract_polyps0.90971524
46MP0001340_abnormal_eyelid_morphology0.86123295
47MP0000465_gastrointestinal_hemorrhage0.76230767
48MP0008438_abnormal_cutaneous_collagen0.75571853
49MP0000569_abnormal_digit_pigmentation0.72368736
50MP0002009_preneoplasia0.66544314
51MP0002282_abnormal_trachea_morphology0.65948297
52MP0004782_abnormal_surfactant_physiolog0.65858687
53MP0010030_abnormal_orbit_morphology0.62476625
54MP0001849_ear_inflammation0.61080167
55MP0008004_abnormal_stomach_pH0.59069838
56* MP0001784_abnormal_fluid_regulation0.59066631
57MP0003011_delayed_dark_adaptation0.58711169
58MP0001485_abnormal_pinna_reflex0.58237493
59MP0000627_abnormal_mammary_gland0.58001231
60MP0002095_abnormal_skin_pigmentation0.57915867
61MP0002177_abnormal_outer_ear0.56971905
62MP0002877_abnormal_melanocyte_morpholog0.54665054
63MP0005075_abnormal_melanosome_morpholog0.54388103
64MP0004264_abnormal_extraembryonic_tissu0.51922336
65MP0003755_abnormal_palate_morphology0.50744138
66MP0006054_spinal_hemorrhage0.49631538
67MP0003315_abnormal_perineum_morphology0.49459413
68MP0005666_abnormal_adipose_tissue0.47410979
69MP0005367_renal/urinary_system_phenotyp0.47360540
70MP0000516_abnormal_urinary_system0.47360540
71MP0005076_abnormal_cell_differentiation0.46557262
72MP0004272_abnormal_basement_membrane0.45841759
73MP0002138_abnormal_hepatobiliary_system0.44663231
74MP0002249_abnormal_larynx_morphology0.44134100
75MP0002111_abnormal_tail_morphology0.41234774
76MP0000538_abnormal_urinary_bladder0.40687274
77MP0001177_atelectasis0.39145308
78MP0003436_decreased_susceptibility_to0.38586421
79MP0005394_taste/olfaction_phenotype0.37336679
80MP0005499_abnormal_olfactory_system0.37336679
81MP0003950_abnormal_plasma_membrane0.37145704
82MP0001984_abnormal_olfaction0.37101974
83MP0000372_irregular_coat_pigmentation0.34849495
84MP0002233_abnormal_nose_morphology0.32152893
85MP0009780_abnormal_chondrocyte_physiolo0.31602762
86MP0005503_abnormal_tendon_morphology0.30904550
87MP0002166_altered_tumor_susceptibility0.30606025
88MP0003385_abnormal_body_wall0.30306110
89MP0005375_adipose_tissue_phenotype0.30212984
90MP0002006_tumorigenesis0.30180211
91MP0002090_abnormal_vision0.28944542
92MP0005623_abnormal_meninges_morphology0.28401185
93MP0003763_abnormal_thymus_physiology0.26628410
94MP0001186_pigmentation_phenotype0.25959615
95MP0002697_abnormal_eye_size0.24547482
96MP0004043_abnormal_pH_regulation0.24538001
97MP0005508_abnormal_skeleton_morphology0.24492202
98MP0001542_abnormal_bone_strength0.24202090
99MP0005388_respiratory_system_phenotype0.23215931
100MP0002133_abnormal_respiratory_system0.23215931
101MP0004019_abnormal_vitamin_homeostasis0.22486244
102MP0000470_abnormal_stomach_morphology0.21245777
103MP0002148_abnormal_hypersensitivity_rea0.20915575
104MP0000750_abnormal_muscle_regeneration0.20450227
105MP0000432_abnormal_head_morphology0.20138692
106MP0004197_abnormal_fetal_growth/weight/0.19805021
107MP0009333_abnormal_splenocyte_physiolog0.19186852
108MP0003136_yellow_coat_color0.18642475
109MP0005248_abnormal_Harderian_gland0.18592022
110MP0003638_abnormal_response/metabolism_0.18525157
111MP0009384_cardiac_valve_regurgitation0.17706448
112MP0009250_abnormal_appendicular_skeleto0.17068545
113MP0000537_abnormal_urethra_morphology0.17043825
114MP0005171_absent_coat_pigmentation0.15945264
115MP0003329_amyloid_beta_deposits0.15749360
116MP0008789_abnormal_olfactory_epithelium0.15512375
117MP0005193_abnormal_anterior_eye0.15425788
118MP0000613_abnormal_salivary_gland0.15269317
119MP0005257_abnormal_intraocular_pressure0.15215704
120MP0002896_abnormal_bone_mineralization0.13597753
121MP0003045_fibrosis0.13138637
122MP0006072_abnormal_retinal_apoptosis0.12955435
123MP0005390_skeleton_phenotype0.12524952
124MP0000685_abnormal_immune_system0.11574566
125MP0002909_abnormal_adrenal_gland0.11132226
126MP0009672_abnormal_birth_weight0.09750101
127MP0002075_abnormal_coat/hair_pigmentati0.08944572
128MP0001756_abnormal_urination0.07172230
129MP0005408_hypopigmentation0.06972395
130MP0001905_abnormal_dopamine_level0.06376039
131MP0008569_lethality_at_weaning0.06359716
132MP0001502_abnormal_circadian_rhythm0.05960120
133MP0000371_diluted_coat_color0.03256357
134MP0008770_decreased_survivor_rate0.02373062

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.73637588
2Increased IgE level (HP:0003212)8.71141893
3Palmoplantar hyperkeratosis (HP:0000972)7.60876016
4Hypotrichosis (HP:0001006)7.50076739
5Plantar hyperkeratosis (HP:0007556)7.41066864
6Palmar hyperkeratosis (HP:0010765)7.18023113
7Thick nail (HP:0001805)6.67649612
8Woolly hair (HP:0002224)6.57525301
9Onycholysis (HP:0001806)6.50064374
10Congenital ichthyosiform erythroderma (HP:0007431)6.15879848
11Right ventricular cardiomyopathy (HP:0011663)5.94935221
12Erythroderma (HP:0001019)5.86294615
13Conjunctival hamartoma (HP:0100780)5.68862102
14Fragile nails (HP:0001808)5.67703110
15Erythema (HP:0010783)5.63215943
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.55197066
17Milia (HP:0001056)5.06782682
18Alopecia of scalp (HP:0002293)4.94656011
19Pili torti (HP:0003777)4.57636402
20Abnormal blistering of the skin (HP:0008066)4.54326472
21Nail dystrophy (HP:0008404)4.24710259
22Absent eyelashes (HP:0000561)4.03372128
23Parakeratosis (HP:0001036)4.00482927
24Lip pit (HP:0100267)3.93075304
25Absent hair (HP:0002298)3.64686995
26Follicular hyperkeratosis (HP:0007502)3.61853993
27Palmoplantar keratoderma (HP:0000982)3.58585242
28Oral leukoplakia (HP:0002745)3.58473854
29Corneal erosion (HP:0200020)3.51881840
30Gangrene (HP:0100758)3.51066752
31Hypohidrosis (HP:0000966)3.49991229
32Hamartoma of the eye (HP:0010568)3.48424909
33Natal tooth (HP:0000695)3.39128126
34Curly hair (HP:0002212)3.35511083
35Ectropion (HP:0000656)3.34734801
36Ridged nail (HP:0001807)3.20844509
37Advanced eruption of teeth (HP:0006288)3.20505892
38Ventricular tachycardia (HP:0004756)3.19426633
39Sparse eyelashes (HP:0000653)3.11770438
40Furrowed tongue (HP:0000221)2.99500041
41Atrophic scars (HP:0001075)2.98905526
42Abnormal hair laboratory examination (HP:0003328)2.98099719
43Hyporeflexia of lower limbs (HP:0002600)2.91279980
44Pruritus (HP:0000989)2.86222240
45Abnormality of placental membranes (HP:0011409)2.62940975
46Amniotic constriction ring (HP:0009775)2.62940975
47Distal lower limb muscle weakness (HP:0009053)2.62486176
48Hypergammaglobulinemia (HP:0010702)2.62369150
49Fatigable weakness (HP:0003473)2.60873206
50Abnormality of the neuromuscular junction (HP:0003398)2.60873206
51Sparse scalp hair (HP:0002209)2.60821093
52Hypoplastic labia majora (HP:0000059)2.58056661
53Acanthosis nigricans (HP:0000956)2.56725993
54Brittle hair (HP:0002299)2.54993177
55Pustule (HP:0200039)2.44513027
56Autoamputation (HP:0001218)2.41665989
57Laryngomalacia (HP:0001601)2.40171214
58Increased connective tissue (HP:0009025)2.39275087
59Corneal dystrophy (HP:0001131)2.37895131
60Abnormality of the labia majora (HP:0012881)2.33275567
61Selective tooth agenesis (HP:0001592)2.23839314
62Hyperhidrosis (HP:0000975)2.19759107
63Anonychia (HP:0001798)2.17752852
64Type 1 muscle fiber predominance (HP:0003803)2.12272422
65Abnormality of secondary sexual hair (HP:0009888)2.11737128
66Abnormality of the axillary hair (HP:0100134)2.11737128
67Round ear (HP:0100830)2.10248792
68Duplicated collecting system (HP:0000081)2.09720052
69Fragile skin (HP:0001030)2.05297089
70Concave nail (HP:0001598)2.03072430
71Blepharitis (HP:0000498)2.02972177
72Lack of skin elasticity (HP:0100679)2.02742966
73Recurrent corneal erosions (HP:0000495)2.01096854
74Abnormality of the gastric mucosa (HP:0004295)1.98013741
75Eczematoid dermatitis (HP:0000976)1.97603833
76Ventricular fibrillation (HP:0001663)1.94032448
77Septate vagina (HP:0001153)1.91849615
78Depressed nasal tip (HP:0000437)1.90910192
79Split foot (HP:0001839)1.90416465
80Aplasia cutis congenita (HP:0001057)1.89495318
81Multifactorial inheritance (HP:0001426)1.88899192
82Abnormality of the salivary glands (HP:0010286)1.84805224
83Myopathic facies (HP:0002058)1.84238494
84Skin ulcer (HP:0200042)1.83547274
85Abnormality of the renal collecting system (HP:0004742)1.83525802
86Conical tooth (HP:0000698)1.82958874
87Severe Myopia (HP:0011003)1.81916941
88Fine hair (HP:0002213)1.78562830
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78193576
90Muscle fiber inclusion bodies (HP:0100299)1.78059880
91Anhidrosis (HP:0000970)1.77270253
92Congenital, generalized hypertrichosis (HP:0004540)1.75691555
93Achilles tendon contracture (HP:0001771)1.74009114
94Nemaline bodies (HP:0003798)1.72081051
95Dry skin (HP:0000958)1.71390338
96Dehydration (HP:0001944)1.71081809
97Abnormality of the fingernails (HP:0001231)1.70608354
98Distal arthrogryposis (HP:0005684)1.68827218
99Sudden death (HP:0001699)1.68808833
100Paralysis (HP:0003470)1.68291457
101Xerostomia (HP:0000217)1.66273152
102Areflexia of lower limbs (HP:0002522)1.63183945
103Abnormality of permanent molar morphology (HP:0011071)1.60969918
104Abnormality of the dental root (HP:0006486)1.60969918
105Taurodontia (HP:0000679)1.60969918
106Oligodontia (HP:0000677)1.60507031
107Hamartoma (HP:0010566)1.59739556
108Abnormality of the Achilles tendon (HP:0005109)1.57840932
109Malignant hyperthermia (HP:0002047)1.56871701
110Labial hypoplasia (HP:0000066)1.56597667
111Carious teeth (HP:0000670)1.56127481
112Sepsis (HP:0100806)1.54915931
113Melanocytic nevus (HP:0000995)1.54392435
114Keratoconjunctivitis sicca (HP:0001097)1.52570286
115Verrucae (HP:0200043)1.52146700
116Papilloma (HP:0012740)1.52146700
117Breast hypoplasia (HP:0003187)1.51746295
118Popliteal pterygium (HP:0009756)1.51342167
119Neck muscle weakness (HP:0000467)1.50973711
120Abnormality of molar (HP:0011077)1.50424487
121Abnormality of molar morphology (HP:0011070)1.50424487
122Nasolacrimal duct obstruction (HP:0000579)1.48689154
123Distal lower limb amyotrophy (HP:0008944)1.48029305
124Premature rupture of membranes (HP:0001788)1.46685080
125Slow-growing hair (HP:0002217)1.45594413
126Abnormality of hair growth rate (HP:0011363)1.45594413
127Abnormality of the dental pulp (HP:0006479)1.45521635
128Dry hair (HP:0011359)1.45384356
129Urticaria (HP:0001025)1.45327988
130Generalized hyperpigmentation (HP:0007440)1.43714774
131Fair hair (HP:0002286)1.43638848
132Calcaneovalgus deformity (HP:0001848)1.43329770
133Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.42991761
134Keratoconjunctivitis (HP:0001096)1.42518970
135Muscle fiber splitting (HP:0003555)1.42455187
136Trismus (HP:0000211)1.42126306
137Pterygium (HP:0001059)1.40957908
138Ulnar deviation of the wrist (HP:0003049)1.40412034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR17.38568877
2MST1R6.01063693
3MAPKAPK34.98601350
4MST44.49043549
5FER3.98137904
6ERN13.00486647
7MAP3K32.99010479
8LATS12.81056802
9PIK3CG2.44288652
10SGK2232.29044163
11SGK4942.29044163
12MAP3K22.24063460
13RPS6KB22.16800574
14EPHB22.14569548
15MET2.03484243
16STK241.99399482
17MAP3K91.98288354
18TRPM71.89287903
19TTN1.81427252
20IRAK11.74259713
21IKBKB1.58051946
22BMPR1B1.56103554
23EEF2K1.53177637
24PIM21.52440712
25EPHA21.52279302
26TAOK11.51533819
27BLK1.47627581
28TRIB31.44715454
29ERBB31.44271713
30GRK61.39851192
31TESK11.36525990
32EPHA31.34736291
33BCR1.34553260
34LRRK21.32758933
35FGFR11.30026552
36OBSCN1.29436186
37NLK1.28845239
38MAP2K61.22794506
39MAP3K111.21901718
40GRK11.20343850
41NME11.18721907
42LATS21.18267679
43EPHB11.17216545
44PTK61.14105946
45STK101.13684964
46MAP3K11.11144615
47MAPK71.09212628
48FGFR41.08624329
49PRKCE1.07678101
50WNK11.07660134
51MAPKAPK51.06044048
52RIPK11.05429526
53FLT31.01978598
54MAPKAPK21.00281854
55RPS6KB11.00258027
56RPS6KA40.99519159
57ACVR1B0.97525166
58TAOK30.95374807
59KIT0.93139062
60CDK60.92531938
61DYRK1B0.90691483
62LIMK10.86938282
63FGFR30.85168201
64SGK20.84714338
65AKT30.84456366
66ADRBK20.83856252
67MAP3K70.81799880
68DMPK0.79186939
69PTK20.77707593
70TYK20.77423003
71INSRR0.75177981
72FGFR20.73931326
73DDR20.73719946
74PINK10.73514258
75TGFBR20.70395748
76PRKAA20.68578982
77EPHA40.65491853
78MAP2K10.64034017
79PAK30.63905179
80MAP3K60.62650549
81NTRK20.61406832
82SGK10.59494249
83MAP4K20.59342121
84MAP2K30.56983063
85PBK0.55470256
86TAF10.53058720
87PRKD10.52883335
88STK380.52719995
89STK390.51118005
90KSR20.50785333
91BMX0.49487496
92NUAK10.48778391
93PRKCI0.48071441
94HIPK20.47819988
95SGK30.47412372
96EIF2AK30.46564496
97SIK10.46092437
98PDGFRA0.45781538
99STK30.44850082
100CSNK1A1L0.44789294
101ABL10.44235850
102TRIM280.43854219
103CASK0.43351326
104RPS6KA10.41077479
105CAMK1D0.39573646
106HCK0.38451893
107ITK0.37704801
108NME20.37645003
109IRAK30.37551844
110STK38L0.35643413
111TYRO30.35353693
112RIPK40.34526866
113NEK90.32944516
114MARK10.32552990
115ROCK10.32342890
116ILK0.32097411
117ERBB20.31554636
118SIK30.30669270
119PKN10.30267872
120FGR0.29037995
121PRKD20.28688649
122MAPK120.28567551
123CHUK0.27918889
124CSNK1D0.27005657
125CAMK1G0.26665286
126PHKG10.26047432
127PHKG20.26047432
128MAP2K40.25979622
129ADRBK10.25840778
130JAK10.25653327
131MATK0.25266804
132JAK30.24560802
133MARK20.23834942
134MAP3K140.22037411
135ERBB40.21875733
136MAP3K50.21619288
137SRC0.21502282
138ROCK20.20943663
139MINK10.20721028
140WNK30.20233142
141BRD40.20165098
142FRK0.20038465
143MAPK90.19445065
144IKBKE0.18707965
145EIF2AK20.18011988
146IGF1R0.17941147
147MAPK40.17764061
148MOS0.15503314
149PAK20.13727908
150GSK3A0.13426416

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.85516229
2Fatty acid elongation_Homo sapiens_hsa000623.84773347
3Linoleic acid metabolism_Homo sapiens_hsa005913.67811957
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.64692409
5Sphingolipid metabolism_Homo sapiens_hsa006003.06078354
6Arachidonic acid metabolism_Homo sapiens_hsa005902.96940346
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35810783
8Ether lipid metabolism_Homo sapiens_hsa005652.11430425
9Histidine metabolism_Homo sapiens_hsa003402.07027440
10Phenylalanine metabolism_Homo sapiens_hsa003601.98373783
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91798535
12Ribosome_Homo sapiens_hsa030101.87377318
13Circadian rhythm_Homo sapiens_hsa047101.76455479
14VEGF signaling pathway_Homo sapiens_hsa043701.74320259
15Steroid biosynthesis_Homo sapiens_hsa001001.71689087
16GnRH signaling pathway_Homo sapiens_hsa049121.51947510
17Staphylococcus aureus infection_Homo sapiens_hsa051501.51194495
18Tight junction_Homo sapiens_hsa045301.49172302
19Adherens junction_Homo sapiens_hsa045201.48132140
20ECM-receptor interaction_Homo sapiens_hsa045121.46231803
21Caffeine metabolism_Homo sapiens_hsa002321.40841031
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34941162
23Phototransduction_Homo sapiens_hsa047441.32831690
24Axon guidance_Homo sapiens_hsa043601.32731645
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31923460
26Fat digestion and absorption_Homo sapiens_hsa049751.25754053
27p53 signaling pathway_Homo sapiens_hsa041151.24357768
28Bladder cancer_Homo sapiens_hsa052191.21675695
29Sphingolipid signaling pathway_Homo sapiens_hsa040711.12000282
30Basal cell carcinoma_Homo sapiens_hsa052171.11708905
31Retinol metabolism_Homo sapiens_hsa008301.09574105
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08106269
33Proteoglycans in cancer_Homo sapiens_hsa052051.05972511
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02070827
35Nitrogen metabolism_Homo sapiens_hsa009100.99194088
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.98718069
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97369191
38Chemical carcinogenesis_Homo sapiens_hsa052040.96282301
39Amoebiasis_Homo sapiens_hsa051460.95645228
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.95228824
41Tyrosine metabolism_Homo sapiens_hsa003500.93754578
42Pertussis_Homo sapiens_hsa051330.93609832
43Melanogenesis_Homo sapiens_hsa049160.90337070
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89599318
45Hippo signaling pathway_Homo sapiens_hsa043900.89051183
46MicroRNAs in cancer_Homo sapiens_hsa052060.88832986
47Ras signaling pathway_Homo sapiens_hsa040140.87407486
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.84809969
49Acute myeloid leukemia_Homo sapiens_hsa052210.84511633
50ABC transporters_Homo sapiens_hsa020100.84057335
51Renin secretion_Homo sapiens_hsa049240.83328434
52Long-term depression_Homo sapiens_hsa047300.82649820
53Fatty acid biosynthesis_Homo sapiens_hsa000610.81963441
54Olfactory transduction_Homo sapiens_hsa047400.80875077
55Pancreatic secretion_Homo sapiens_hsa049720.80578344
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80470647
57Dorso-ventral axis formation_Homo sapiens_hsa043200.78824930
58Glutamatergic synapse_Homo sapiens_hsa047240.78680448
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.78124974
60Thyroid cancer_Homo sapiens_hsa052160.75850753
61Platelet activation_Homo sapiens_hsa046110.72291198
62Serotonergic synapse_Homo sapiens_hsa047260.72210919
63Gastric acid secretion_Homo sapiens_hsa049710.72124593
64beta-Alanine metabolism_Homo sapiens_hsa004100.71727935
65Hedgehog signaling pathway_Homo sapiens_hsa043400.71702558
66Circadian entrainment_Homo sapiens_hsa047130.69694949
67Glioma_Homo sapiens_hsa052140.68731027
68Hepatitis C_Homo sapiens_hsa051600.67946203
69Protein digestion and absorption_Homo sapiens_hsa049740.65833953
70Oxytocin signaling pathway_Homo sapiens_hsa049210.64484827
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63907077
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63410190
73Toxoplasmosis_Homo sapiens_hsa051450.62231671
74Mineral absorption_Homo sapiens_hsa049780.60862496
75Rap1 signaling pathway_Homo sapiens_hsa040150.60591338
76TGF-beta signaling pathway_Homo sapiens_hsa043500.59860753
77Focal adhesion_Homo sapiens_hsa045100.59510302
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56931419
79Estrogen signaling pathway_Homo sapiens_hsa049150.56533337
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55543480
81Ovarian steroidogenesis_Homo sapiens_hsa049130.54806223
82PPAR signaling pathway_Homo sapiens_hsa033200.51503235
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51491074
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49832661
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.49017581
86Small cell lung cancer_Homo sapiens_hsa052220.48531015
87Amphetamine addiction_Homo sapiens_hsa050310.48243720
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46874548
89Long-term potentiation_Homo sapiens_hsa047200.46830493
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45706725
91ErbB signaling pathway_Homo sapiens_hsa040120.44688933
92Glucagon signaling pathway_Homo sapiens_hsa049220.42610985
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42275401
94Dopaminergic synapse_Homo sapiens_hsa047280.41074548
95Endocytosis_Homo sapiens_hsa041440.40532535
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40218590
97Choline metabolism in cancer_Homo sapiens_hsa052310.40013705
98Tuberculosis_Homo sapiens_hsa051520.39419027
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.38935556
100Glycerolipid metabolism_Homo sapiens_hsa005610.38500130
101Salivary secretion_Homo sapiens_hsa049700.38264501
102Calcium signaling pathway_Homo sapiens_hsa040200.38243184
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38175048
104Dilated cardiomyopathy_Homo sapiens_hsa054140.38015017
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37999225
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37681668
107Melanoma_Homo sapiens_hsa052180.35626231
108Renal cell carcinoma_Homo sapiens_hsa052110.34914726
109Wnt signaling pathway_Homo sapiens_hsa043100.34626932
110Collecting duct acid secretion_Homo sapiens_hsa049660.34200231
111Glutathione metabolism_Homo sapiens_hsa004800.33647318
112Salmonella infection_Homo sapiens_hsa051320.33626605
113TNF signaling pathway_Homo sapiens_hsa046680.31962314
114Insulin resistance_Homo sapiens_hsa049310.31931588
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.31872170
116cAMP signaling pathway_Homo sapiens_hsa040240.31813647
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31210356
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31161164
119Inositol phosphate metabolism_Homo sapiens_hsa005620.28763231
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28256119
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27919665
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27162335
123Vitamin digestion and absorption_Homo sapiens_hsa049770.25305927
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.21759409
125Insulin signaling pathway_Homo sapiens_hsa049100.21726228
126MAPK signaling pathway_Homo sapiens_hsa040100.21288386
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20697046
128Arginine biosynthesis_Homo sapiens_hsa002200.19196304
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18700789

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