ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.34618120
2	fucose catabolic process (GO:0019317)	4.52590184
3	L-fucose metabolic process (GO:0042354)	4.52590184
4	L-fucose catabolic process (GO:0042355)	4.52590184
5	protein polyglutamylation (GO:0018095)	3.85346978
6	response to pheromone (GO:0019236)	3.79438915
7	negative regulation of telomere maintenance (GO:0032205)	3.66232495
8	gamma-aminobutyric acid transport (GO:0015812)	3.59606505
9	axoneme assembly (GO:0035082)	3.55761313
10	pyrimidine nucleobase catabolic process (GO:0006208)	3.54273708
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.49001995
12	nonmotile primary cilium assembly (GO:0035058)	3.43693913
13	nucleobase catabolic process (GO:0046113)	3.42146711
14	tryptophan catabolic process (GO:0006569)	3.36253460
15	indole-containing compound catabolic process (GO:0042436)	3.36253460
16	indolalkylamine catabolic process (GO:0046218)	3.36253460
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.32190469
18	detection of light stimulus involved in visual perception (GO:0050908)	3.32190469
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30735970
20	indolalkylamine metabolic process (GO:0006586)	3.29938414
21	DNA deamination (GO:0045006)	3.26650421
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.23293964
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.21350616
24	estrogen biosynthetic process (GO:0006703)	3.19721280
25	kynurenine metabolic process (GO:0070189)	3.18384165
26	drug catabolic process (GO:0042737)	3.14674269
27	epithelial cilium movement (GO:0003351)	3.14671178
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09145629
29	NADH dehydrogenase complex assembly (GO:0010257)	3.09145629
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09145629
31	exogenous drug catabolic process (GO:0042738)	3.05081194
32	platelet dense granule organization (GO:0060155)	3.04844004
33	piRNA metabolic process (GO:0034587)	3.02371149
34	cellular ketone body metabolic process (GO:0046950)	3.01487192
35	protein complex biogenesis (GO:0070271)	2.96103076
36	photoreceptor cell maintenance (GO:0045494)	2.93346105
37	ketone body metabolic process (GO:1902224)	2.90097419
38	protein localization to cilium (GO:0061512)	2.88501497
39	regulation of cilium movement (GO:0003352)	2.84883768
40	cellular biogenic amine catabolic process (GO:0042402)	2.83717182
41	amine catabolic process (GO:0009310)	2.83717182
42	tryptophan metabolic process (GO:0006568)	2.83575458
43	proline transport (GO:0015824)	2.82356204
44	protein-cofactor linkage (GO:0018065)	2.81205626
45	ubiquinone biosynthetic process (GO:0006744)	2.80985322
46	nephron epithelium morphogenesis (GO:0072088)	2.79290285
47	nephron tubule morphogenesis (GO:0072078)	2.79290285
48	respiratory chain complex IV assembly (GO:0008535)	2.77375550
49	transepithelial transport (GO:0070633)	2.77239443
50	sulfation (GO:0051923)	2.76166827
51	regulation of action potential (GO:0098900)	2.74905340
52	synaptic transmission, cholinergic (GO:0007271)	2.74394592
53	retinal cone cell development (GO:0046549)	2.73047744
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.72865208
55	behavioral response to ethanol (GO:0048149)	2.72556801
56	cilium morphogenesis (GO:0060271)	2.71620721
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.71582531
58	neuronal action potential (GO:0019228)	2.71485769
59	ubiquinone metabolic process (GO:0006743)	2.69116100
60	quinone biosynthetic process (GO:1901663)	2.66800249
61	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.66150303
62	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.66150303
63	cornea development in camera-type eye (GO:0061303)	2.65844351
64	auditory receptor cell stereocilium organization (GO:0060088)	2.60595352
65	regulation of microtubule-based movement (GO:0060632)	2.60544695
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.59807097
67	indole-containing compound metabolic process (GO:0042430)	2.58886305
68	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.58682221
69	S-adenosylmethionine metabolic process (GO:0046500)	2.57544391
70	cilium movement (GO:0003341)	2.57160476
71	photoreceptor cell development (GO:0042461)	2.54089679
72	fucosylation (GO:0036065)	2.53642050
73	regulation of telomere maintenance (GO:0032204)	2.52786921
74	positive regulation of fatty acid transport (GO:2000193)	2.52420008
75	transmission of nerve impulse (GO:0019226)	2.52084917
76	regulation of neurotransmitter uptake (GO:0051580)	2.51820053
77	arginine metabolic process (GO:0006525)	2.51513001
78	glycerophospholipid catabolic process (GO:0046475)	2.47985229
79	parturition (GO:0007567)	2.46511684
80	benzene-containing compound metabolic process (GO:0042537)	2.46046114
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45197340
82	protein deneddylation (GO:0000338)	2.44640777
83	positive regulation of prostaglandin secretion (GO:0032308)	2.44436726
84	GPI anchor metabolic process (GO:0006505)	2.44290143
85	cilium organization (GO:0044782)	2.43718834
86	alkaloid metabolic process (GO:0009820)	2.42325889
87	amino acid salvage (GO:0043102)	2.42280090
88	L-methionine salvage (GO:0071267)	2.42280090
89	L-methionine biosynthetic process (GO:0071265)	2.42280090
90	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42261759
91	mannosylation (GO:0097502)	2.41965051
92	oxidative demethylation (GO:0070989)	2.40033262
93	rhodopsin mediated signaling pathway (GO:0016056)	2.39975055
94	response to misfolded protein (GO:0051788)	2.39301922
95	DNA methylation involved in gamete generation (GO:0043046)	2.39239067
96	inner ear receptor stereocilium organization (GO:0060122)	2.39055725
97	reflex (GO:0060004)	2.38520001
98	primary amino compound metabolic process (GO:1901160)	2.37963071
99	cytochrome complex assembly (GO:0017004)	2.36368532
100	protein K11-linked deubiquitination (GO:0035871)	2.36057125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.22024251
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.36481240
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18249232
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.76513144
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.68450728
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.61829543
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58082695
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54767716
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16025578
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06370060
11	FUS_26573619_Chip-Seq_HEK293_Human	2.04236481
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00501487
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98747168
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.95348223
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94552823
16	EWS_26573619_Chip-Seq_HEK293_Human	1.94023108
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88288724
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86308792
19	P300_19829295_ChIP-Seq_ESCs_Human	1.86262272
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.80548996
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79317376
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73600047
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.73127717
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.68051430
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66767045
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.66539250
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59058442
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54345012
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51533780
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.51531507
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51531507
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50340653
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47967106
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.47211450
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.46579509
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43130656
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41864202
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41014799
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.40768653
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40661933
41	STAT3_23295773_ChIP-Seq_U87_Human	1.40237200
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39745313
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38298793
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37089688
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37089688
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36697523
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35835153
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33727026
49	AR_25329375_ChIP-Seq_VCAP_Human	1.33665541
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33462352
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31440541
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31029986
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30863379
54	NCOR_22424771_ChIP-Seq_293T_Human	1.30007226
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29371361
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29371361
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26409756
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26257249
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26065887
60	TCF4_23295773_ChIP-Seq_U87_Human	1.25192172
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23624790
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23619351
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23619351
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.22677225
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21468941
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21082616
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20204998
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19952392
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19238443
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18927926
71	AR_20517297_ChIP-Seq_VCAP_Human	1.18042113
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17962545
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17391956
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15076871
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14173040
76	ERA_21632823_ChIP-Seq_H3396_Human	1.13606806
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12692895
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.10769980
79	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10545595
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09760199
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08428572
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07610938
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06697562
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06110192
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06108303
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05915276
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03519345
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03439002
89	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02897959
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01540230
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99824374
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99365192
93	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.99168839
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98829026
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98353786
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95721099
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95138108
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.94917053
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94644790
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93993110

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.07710771
2	MP0008877_abnormal_DNA_methylation	2.57287704
3	MP0005551_abnormal_eye_electrophysiolog	2.50519765
4	MP0003011_delayed_dark_adaptation	2.47580856
5	MP0003136_yellow_coat_color	2.39823520
6	MP0005645_abnormal_hypothalamus_physiol	2.33984598
7	MP0002102_abnormal_ear_morphology	2.33930301
8	MP0002876_abnormal_thyroid_physiology	2.32714896
9	MP0001986_abnormal_taste_sensitivity	2.24838709
10	MP0002653_abnormal_ependyma_morphology	2.21041412
11	MP0006276_abnormal_autonomic_nervous	2.17668061
12	MP0001968_abnormal_touch/_nociception	2.05279515
13	MP0008875_abnormal_xenobiotic_pharmacok	1.97883716
14	MP0003122_maternal_imprinting	1.97380328
15	MP0003787_abnormal_imprinting	1.94919810
16	MP0003646_muscle_fatigue	1.92231244
17	MP0002837_dystrophic_cardiac_calcinosis	1.92196471
18	MP0004142_abnormal_muscle_tone	1.89283582
19	MP0001529_abnormal_vocalization	1.88883566
20	MP0009745_abnormal_behavioral_response	1.88027536
21	MP0000372_irregular_coat_pigmentation	1.85679389
22	MP0005646_abnormal_pituitary_gland	1.83689063
23	MP0004133_heterotaxia	1.82903428
24	MP0009046_muscle_twitch	1.81152225
25	MP0005360_urolithiasis	1.80311159
26	MP0005253_abnormal_eye_physiology	1.78830875
27	MP0002638_abnormal_pupillary_reflex	1.73749755
28	MP0005085_abnormal_gallbladder_physiolo	1.72568742
29	MP0008872_abnormal_physiological_respon	1.67190566
30	MP0004043_abnormal_pH_regulation	1.65565006
31	MP0005084_abnormal_gallbladder_morpholo	1.63721595
32	MP0006072_abnormal_retinal_apoptosis	1.60401068
33	MP0002736_abnormal_nociception_after	1.59366276
34	MP0005365_abnormal_bile_salt	1.56476698
35	MP0001501_abnormal_sleep_pattern	1.56204550
36	MP0002272_abnormal_nervous_system	1.53961385
37	MP0004885_abnormal_endolymph	1.48245648
38	MP0002557_abnormal_social/conspecific_i	1.47882189
39	MP0002938_white_spotting	1.46758312
40	MP0002163_abnormal_gland_morphology	1.45753926
41	MP0001984_abnormal_olfaction	1.44771670
42	MP0001486_abnormal_startle_reflex	1.40532267
43	MP0005379_endocrine/exocrine_gland_phen	1.40284529
44	MP0006292_abnormal_olfactory_placode	1.39241587
45	MP0003880_abnormal_central_pattern	1.39129979
46	MP0000631_abnormal_neuroendocrine_gland	1.38804464
47	MP0004147_increased_porphyrin_level	1.37634819
48	MP0005386_behavior/neurological_phenoty	1.35952890
49	MP0004924_abnormal_behavior	1.35952890
50	MP0010386_abnormal_urinary_bladder	1.35018472
51	MP0002064_seizures	1.33894734
52	MP0002572_abnormal_emotion/affect_behav	1.32616166
53	MP0001485_abnormal_pinna_reflex	1.29665785
54	MP0002733_abnormal_thermal_nociception	1.28277731
55	MP0005174_abnormal_tail_pigmentation	1.27214337
56	MP0001970_abnormal_pain_threshold	1.25756387
57	MP0000427_abnormal_hair_cycle	1.25163203
58	MP0001502_abnormal_circadian_rhythm	1.22153377
59	MP0001905_abnormal_dopamine_level	1.18817081
60	MP0003635_abnormal_synaptic_transmissio	1.15649807
61	MP0005332_abnormal_amino_acid	1.14993003
62	MP0010329_abnormal_lipoprotein_level	1.10714771
63	MP0004019_abnormal_vitamin_homeostasis	1.10695734
64	MP0003121_genomic_imprinting	1.09997705
65	MP0005195_abnormal_posterior_eye	1.09213311
66	MP0000538_abnormal_urinary_bladder	1.08478547
67	MP0002063_abnormal_learning/memory/cond	1.07585765
68	MP0002160_abnormal_reproductive_system	1.07108108
69	MP0005377_hearing/vestibular/ear_phenot	1.04867776
70	MP0003878_abnormal_ear_physiology	1.04867776
71	MP0000778_abnormal_nervous_system	1.04693013
72	MP0004742_abnormal_vestibular_system	1.03942786
73	MP0002734_abnormal_mechanical_nocicepti	1.03217130
74	MP0000230_abnormal_systemic_arterial	0.99715979
75	MP0003252_abnormal_bile_duct	0.98724152
76	MP0002928_abnormal_bile_duct	0.98612920
77	MP0002909_abnormal_adrenal_gland	0.98254160
78	MP0005423_abnormal_somatic_nervous	0.97919779
79	MP0002067_abnormal_sensory_capabilities	0.96936162
80	MP0005389_reproductive_system_phenotype	0.95520278
81	MP0003718_maternal_effect	0.91310308
82	MP0008789_abnormal_olfactory_epithelium	0.90331325
83	MP0003137_abnormal_impulse_conducting	0.88945709
84	MP0005410_abnormal_fertilization	0.88864810
85	MP0002752_abnormal_somatic_nervous	0.88422162
86	MP0005448_abnormal_energy_balance	0.87522417
87	MP0008775_abnormal_heart_ventricle	0.87193252
88	MP0000026_abnormal_inner_ear	0.86570357
89	MP0002229_neurodegeneration	0.86464567
90	MP0001756_abnormal_urination	0.83693478
91	MP0005171_absent_coat_pigmentation	0.83291155
92	MP0001764_abnormal_homeostasis	0.82708222
93	MP0001664_abnormal_digestion	0.80785119
94	MP0001324_abnormal_eye_pigmentation	0.80403916
95	MP0001919_abnormal_reproductive_system	0.80051312
96	MP0002735_abnormal_chemical_nociception	0.79759854
97	MP0002139_abnormal_hepatobiliary_system	0.77843844
98	MP0002069_abnormal_eating/drinking_beha	0.76902879
99	MP0004215_abnormal_myocardial_fiber	0.76658509
100	MP0003698_abnormal_male_reproductive	0.75638197

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.39755780
2	Congenital stationary night blindness (HP:0007642)	4.33077244
3	Abnormality of midbrain morphology (HP:0002418)	4.02155783
4	Molar tooth sign on MRI (HP:0002419)	4.02155783
5	Pancreatic fibrosis (HP:0100732)	3.97392142
6	True hermaphroditism (HP:0010459)	3.81468137
7	Type II lissencephaly (HP:0007260)	3.73651967
8	Nephronophthisis (HP:0000090)	3.68480295
9	Attenuation of retinal blood vessels (HP:0007843)	3.37057996
10	Medial flaring of the eyebrow (HP:0010747)	3.35276615
11	Abnormality of the renal medulla (HP:0100957)	3.18677295
12	Cerebellar dysplasia (HP:0007033)	3.05339523
13	Pendular nystagmus (HP:0012043)	3.03732850
14	Hyperventilation (HP:0002883)	3.03312895
15	Abnormality of the renal cortex (HP:0011035)	2.99441864
16	Chronic hepatic failure (HP:0100626)	2.93251819
17	Tubular atrophy (HP:0000092)	2.89147591
18	Gait imbalance (HP:0002141)	2.84031995
19	Abolished electroretinogram (ERG) (HP:0000550)	2.71062013
20	Decreased central vision (HP:0007663)	2.68888675
21	Lissencephaly (HP:0001339)	2.68452714
22	Congenital primary aphakia (HP:0007707)	2.61729916
23	Cystic liver disease (HP:0006706)	2.60735130
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.58107516
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56517028
26	Abnormal drinking behavior (HP:0030082)	2.51585293
27	Polydipsia (HP:0001959)	2.51585293
28	Nephrogenic diabetes insipidus (HP:0009806)	2.49432884
29	3-Methylglutaconic aciduria (HP:0003535)	2.41254590
30	Acute necrotizing encephalopathy (HP:0006965)	2.39671278
31	Abnormal biliary tract physiology (HP:0012439)	2.32677892
32	Bile duct proliferation (HP:0001408)	2.32677892
33	Abnormality of macular pigmentation (HP:0008002)	2.32476112
34	Sclerocornea (HP:0000647)	2.32397783
35	Abnormality of the labia minora (HP:0012880)	2.31767296
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.28517256
37	Increased corneal curvature (HP:0100692)	2.27479019
38	Keratoconus (HP:0000563)	2.27479019
39	Increased CSF lactate (HP:0002490)	2.23820527
40	Mitochondrial inheritance (HP:0001427)	2.22692341
41	Inability to walk (HP:0002540)	2.22239881
42	Large for gestational age (HP:0001520)	2.19683891
43	Acute encephalopathy (HP:0006846)	2.18295913
44	Rib fusion (HP:0000902)	2.16608484
45	Polyphagia (HP:0002591)	2.15906451
46	Polyuria (HP:0000103)	2.14160315
47	Renal cortical cysts (HP:0000803)	2.13943147
48	Pachygyria (HP:0001302)	2.13067147
49	Genital tract atresia (HP:0001827)	2.12984531
50	Vaginal atresia (HP:0000148)	2.09749452
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08620636
52	Abnormality of alanine metabolism (HP:0010916)	2.08620636
53	Hyperalaninemia (HP:0003348)	2.08620636
54	Congenital hepatic fibrosis (HP:0002612)	2.08430028
55	Hypoplasia of the pons (HP:0012110)	2.08179926
56	Optic disc pallor (HP:0000543)	2.07276110
57	Lipid accumulation in hepatocytes (HP:0006561)	2.07217530
58	Progressive inability to walk (HP:0002505)	2.07078744
59	Gaze-evoked nystagmus (HP:0000640)	2.07074148
60	Anencephaly (HP:0002323)	2.06338045
61	Progressive macrocephaly (HP:0004481)	2.05939171
62	Hyperglycinuria (HP:0003108)	2.02294082
63	Optic nerve hypoplasia (HP:0000609)	2.01712137
64	Abnormality of the pons (HP:0007361)	2.01676815
65	Hypothermia (HP:0002045)	2.00775823
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00499361
67	Severe muscular hypotonia (HP:0006829)	1.99177305
68	Male pseudohermaphroditism (HP:0000037)	1.98305949
69	Decreased circulating renin level (HP:0003351)	1.96204529
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95215544
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95147351
72	Abnormality of urine glucose concentration (HP:0011016)	1.94446140
73	Glycosuria (HP:0003076)	1.94446140
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.91946474
75	Chorioretinal atrophy (HP:0000533)	1.90948878
76	Thyroid-stimulating hormone excess (HP:0002925)	1.89557552
77	Hypoplasia of the fovea (HP:0007750)	1.89221695
78	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.89221695
79	Absent/shortened dynein arms (HP:0200106)	1.87834622
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.87834622
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86776916
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.86776916
83	Abnormal urine output (HP:0012590)	1.85747411
84	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84840725
85	Progressive cerebellar ataxia (HP:0002073)	1.83509833
86	Patellar aplasia (HP:0006443)	1.83303813
87	Hepatocellular necrosis (HP:0001404)	1.83019297
88	Hepatic necrosis (HP:0002605)	1.82879688
89	Concave nail (HP:0001598)	1.80107153
90	Furrowed tongue (HP:0000221)	1.79469724
91	Postaxial hand polydactyly (HP:0001162)	1.78504604
92	Poor coordination (HP:0002370)	1.78485655
93	Congenital sensorineural hearing impairment (HP:0008527)	1.78340770
94	Agitation (HP:0000713)	1.77097663
95	Postaxial foot polydactyly (HP:0001830)	1.77090870
96	Retinitis pigmentosa (HP:0000510)	1.76797797
97	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76588329
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76386867
99	Intestinal atresia (HP:0011100)	1.76088513
100	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74500531

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.87132887
2	ADRBK2	3.55167637
3	WNK3	3.24812591
4	MAP4K2	3.02568244
5	WNK4	2.72340949
6	TAOK3	2.64972470
7	BMPR1B	2.60631221
8	ZAK	2.55585675
9	TRIM28	2.35847846
10	GRK1	2.26955478
11	ACVR1B	2.20971078
12	TLK1	2.19527870
13	PINK1	2.15205455
14	MAPK13	1.97460182
15	MAP3K4	1.91621438
16	TNIK	1.85573586
17	CASK	1.81509277
18	NUAK1	1.77291234
19	TXK	1.76048020
20	MARK1	1.75253729
21	INSRR	1.70494610
22	OXSR1	1.58894870
23	DAPK2	1.52762094
24	DYRK2	1.49529318
25	STK39	1.46251112
26	BCR	1.34921747
27	MAP2K6	1.32598418
28	MAPK15	1.31986386
29	MAP2K7	1.31841556
30	PAK3	1.23396737
31	ADRBK1	1.23073846
32	CSNK1G2	1.18845872
33	EPHA3	1.15952524
34	BCKDK	1.12158552
35	PHKG2	1.06509904
36	PHKG1	1.06509904
37	PRKCG	1.02005395
38	MKNK2	0.98693729
39	CSNK1G3	0.98413337
40	CSNK1G1	0.91293963
41	PRKCE	0.90659373
42	TIE1	0.87600059
43	MAPKAPK3	0.84317461
44	PLK2	0.83749280
45	CSNK1A1L	0.82729625
46	CAMKK2	0.82213866
47	PIK3CA	0.79169531
48	PRKCH	0.71464583
49	PRKCQ	0.69528859
50	NTRK3	0.66655524
51	ERBB3	0.62836896
52	CSNK1A1	0.59618841
53	CAMK2A	0.58796118
54	SIK2	0.58338632
55	TEC	0.56526148
56	MUSK	0.56470404
57	GRK5	0.55022044
58	CDK19	0.55009270
59	TGFBR1	0.53804888
60	NME1	0.53259382
61	PRKCI	0.52169087
62	EPHA4	0.52010893
63	FER	0.51647614
64	PRKACA	0.51635044
65	RPS6KA5	0.50623174
66	PTK2B	0.49149393
67	VRK1	0.48140604
68	IRAK1	0.47229896
69	STK11	0.46906918
70	STK16	0.46631245
71	EIF2AK3	0.45567014
72	MAPKAPK5	0.45013151
73	PRKCZ	0.43928947
74	DYRK1A	0.42565528
75	CSNK1D	0.41975546
76	PRKCA	0.40584555
77	PIM2	0.38935766
78	PKN1	0.38789352
79	ERBB2	0.37468042
80	NTRK2	0.37292137
81	IKBKB	0.36603442
82	CAMK2D	0.36149232
83	MAP2K4	0.36116393
84	TYRO3	0.35791946
85	PNCK	0.35122327
86	PRKAA1	0.33907033
87	TNK2	0.33650037
88	GRK7	0.33474246
89	CAMK1	0.33074123
90	DAPK1	0.31676110
91	PRKG1	0.31218425
92	DYRK3	0.29935606
93	PLK4	0.29906444
94	STK38L	0.29869744
95	PRKAA2	0.29718027
96	PLK3	0.29291914
97	FGFR2	0.28249167
98	MKNK1	0.27246703
99	NLK	0.27143462
100	STK3	0.26130769

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.70007488
2	Phototransduction_Homo sapiens_hsa04744	2.64532870
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.62543452
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.54464691
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41247417
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34986599
7	Butanoate metabolism_Homo sapiens_hsa00650	2.32439241
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15026726
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03715334
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98068755
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.94645051
12	Caffeine metabolism_Homo sapiens_hsa00232	1.93609105
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.89544383
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.88179618
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86165598
16	RNA polymerase_Homo sapiens_hsa03020	1.84581931
17	Nicotine addiction_Homo sapiens_hsa05033	1.82770034
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.82690106
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.81234280
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.74354332
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70805634
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.68667540
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65739373
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.64278001
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.60262796
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56283255
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.53689213
28	Parkinsons disease_Homo sapiens_hsa05012	1.50696909
29	Retinol metabolism_Homo sapiens_hsa00830	1.49958441
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49438470
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.41804636
32	Protein export_Homo sapiens_hsa03060	1.33077910
33	Peroxisome_Homo sapiens_hsa04146	1.33015366
34	Propanoate metabolism_Homo sapiens_hsa00640	1.28558323
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.24457032
36	Taste transduction_Homo sapiens_hsa04742	1.24390631
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.23338659
38	Morphine addiction_Homo sapiens_hsa05032	1.23011754
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19849310
40	Olfactory transduction_Homo sapiens_hsa04740	1.14693287
41	ABC transporters_Homo sapiens_hsa02010	1.09780705
42	Basal transcription factors_Homo sapiens_hsa03022	1.06988910
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.05260073
44	GABAergic synapse_Homo sapiens_hsa04727	1.04980335
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04099445
46	Glycerolipid metabolism_Homo sapiens_hsa00561	1.00867007
47	Sulfur metabolism_Homo sapiens_hsa00920	0.98317998
48	Insulin secretion_Homo sapiens_hsa04911	0.96328737
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95649228
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95364966
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.93955186
52	Huntingtons disease_Homo sapiens_hsa05016	0.93195179
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.92614641
54	Regulation of autophagy_Homo sapiens_hsa04140	0.92479965
55	Homologous recombination_Homo sapiens_hsa03440	0.90352509
56	Circadian entrainment_Homo sapiens_hsa04713	0.90132188
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89283110
58	Histidine metabolism_Homo sapiens_hsa00340	0.88928731
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87303256
60	RNA degradation_Homo sapiens_hsa03018	0.85408977
61	Alzheimers disease_Homo sapiens_hsa05010	0.82845651
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82127250
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.81821318
64	Sulfur relay system_Homo sapiens_hsa04122	0.81766317
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81121338
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79919459
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78613149
68	Serotonergic synapse_Homo sapiens_hsa04726	0.78218631
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77680298
70	Fatty acid degradation_Homo sapiens_hsa00071	0.76627444
71	Metabolic pathways_Homo sapiens_hsa01100	0.72606998
72	One carbon pool by folate_Homo sapiens_hsa00670	0.70950893
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69769416
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68207471
75	Fatty acid elongation_Homo sapiens_hsa00062	0.64560214
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61309834
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60191281
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59870462
79	Salivary secretion_Homo sapiens_hsa04970	0.58318271
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58218471
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56162140
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55385950
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.55232760
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54299459
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.53526010
86	Mineral absorption_Homo sapiens_hsa04978	0.51485625
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51274503
88	Purine metabolism_Homo sapiens_hsa00230	0.50963261
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45100616
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.44547386
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.42238240
92	Bile secretion_Homo sapiens_hsa04976	0.41995673
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.41296547
94	Cocaine addiction_Homo sapiens_hsa05030	0.38731365
95	Long-term depression_Homo sapiens_hsa04730	0.38387136
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37522254
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37489708
98	Circadian rhythm_Homo sapiens_hsa04710	0.37231688
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36805988
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.35566499

CASP16P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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