CASP1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.45087815
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36433292
3negative regulation of cell killing (GO:0031342)6.36433292
4regulation of regulatory T cell differentiation (GO:0045589)5.76036418
5negative T cell selection (GO:0043383)5.73872836
6positive regulation of gamma-delta T cell activation (GO:0046645)5.71776366
7negative regulation of T cell mediated immunity (GO:0002710)5.59121943
8tolerance induction (GO:0002507)5.30579531
9negative thymic T cell selection (GO:0045060)5.27366643
10cellular response to interleukin-15 (GO:0071350)5.13697939
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10556000
12response to interleukin-15 (GO:0070672)4.90735867
13positive T cell selection (GO:0043368)4.71540333
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71351560
15regulation of T cell tolerance induction (GO:0002664)4.68585297
16antigen processing and presentation of endogenous antigen (GO:0019883)4.68459016
17positive regulation of tolerance induction (GO:0002645)4.61238788
18regulation of B cell receptor signaling pathway (GO:0050855)4.40007249
19negative regulation of lymphocyte mediated immunity (GO:0002707)4.36824962
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35422396
21regulation of tolerance induction (GO:0002643)4.21965422
22T cell selection (GO:0045058)4.18435129
23regulation of gamma-delta T cell activation (GO:0046643)4.15277012
24positive thymic T cell selection (GO:0045059)4.08783379
25mast cell activation (GO:0045576)4.06376625
26activated T cell proliferation (GO:0050798)4.06192598
27regulation of gamma-delta T cell differentiation (GO:0045586)4.06067431
28regulation of alpha-beta T cell proliferation (GO:0046640)4.02685306
29leukocyte aggregation (GO:0070486)4.02621615
30regulation of T cell mediated cytotoxicity (GO:0001914)4.01278630
31positive regulation of granulocyte differentiation (GO:0030854)4.00369630
32positive regulation of alpha-beta T cell proliferation (GO:0046641)3.88421421
33interferon-gamma-mediated signaling pathway (GO:0060333)3.83658156
34detection of other organism (GO:0098543)3.83605922
35positive regulation of T cell mediated cytotoxicity (GO:0001916)3.79197066
36thymic T cell selection (GO:0045061)3.78085973
37type I interferon signaling pathway (GO:0060337)3.77457599
38cellular response to type I interferon (GO:0071357)3.77457599
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76251808
40response to type I interferon (GO:0034340)3.74703789
41positive regulation of T cell differentiation in thymus (GO:0033089)3.74215205
42T cell migration (GO:0072678)3.73040664
43negative regulation of interleukin-12 production (GO:0032695)3.72767894
44response to interferon-beta (GO:0035456)3.71849564
45regulation of isotype switching to IgG isotypes (GO:0048302)3.71233734
46cellular response to interferon-beta (GO:0035458)3.61965496
47negative regulation of leukocyte mediated immunity (GO:0002704)3.58923979
48detection of bacterium (GO:0016045)3.58704878
49neutrophil activation involved in immune response (GO:0002283)3.56697620
50antigen processing and presentation via MHC class Ib (GO:0002475)3.53636179
51T cell receptor signaling pathway (GO:0050852)3.53012584
52antigen receptor-mediated signaling pathway (GO:0050851)3.50931802
53B cell receptor signaling pathway (GO:0050853)3.49792708
54immunoglobulin mediated immune response (GO:0016064)3.49138197
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.47350827
56negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.44779334
57positive regulation by organism of defense response of other organism involved in symbiotic interact3.41987828
58modulation by symbiont of host immune response (GO:0052553)3.41987828
59positive regulation by symbiont of host defense response (GO:0052509)3.41987828
60modulation by symbiont of host defense response (GO:0052031)3.41987828
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41987828
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41987828
63microglial cell activation (GO:0001774)3.39913289
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35008866
65positive regulation of defense response to virus by host (GO:0002230)3.31164892
66positive regulation of B cell differentiation (GO:0045579)3.28049758
67regulation of B cell differentiation (GO:0045577)3.22495033
68regulation of T cell mediated immunity (GO:0002709)3.21336376
69production of molecular mediator involved in inflammatory response (GO:0002532)3.20176395
70detection of external biotic stimulus (GO:0098581)3.19935376
71negative regulation of adaptive immune response (GO:0002820)3.19749763
72neutrophil activation (GO:0042119)3.18931269
73positive regulation of T cell mediated immunity (GO:0002711)3.18315436
74alpha-beta T cell differentiation (GO:0046632)3.16159460
75positive regulation of interleukin-1 beta secretion (GO:0050718)3.15765400
76positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.11168820
77negative regulation of B cell proliferation (GO:0030889)3.11034743
78negative regulation of B cell mediated immunity (GO:0002713)3.09995090
79negative regulation of immunoglobulin mediated immune response (GO:0002890)3.09995090
80positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.09975043
81regulation of leukocyte mediated cytotoxicity (GO:0001910)3.09670315
82T cell costimulation (GO:0031295)3.09285005
83regulation of interleukin-1 beta secretion (GO:0050706)3.09174793
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.08221401
85detection of molecule of bacterial origin (GO:0032490)3.07751822
86interferon-gamma production (GO:0032609)3.07609803
87G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.05530094
88lymphocyte costimulation (GO:0031294)3.05070198
89regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.03366866
90B cell mediated immunity (GO:0019724)3.02770146
91positive regulation of interleukin-4 production (GO:0032753)2.99135217
92myeloid cell activation involved in immune response (GO:0002275)2.98953869
93positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.97868188
94cellular extravasation (GO:0045123)2.97857370
95positive regulation of interleukin-1 secretion (GO:0050716)2.96548366
96macrophage activation involved in immune response (GO:0002281)2.96382098
97mast cell activation involved in immune response (GO:0002279)2.95445120
98mast cell degranulation (GO:0043303)2.95445120
99positive regulation of interleukin-1 beta production (GO:0032731)2.94974383
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94612129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.09365675
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.38362715
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.58343990
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.72042014
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.20545215
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75932467
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61185260
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.57573135
9RUNX_20019798_ChIP-Seq_JUKART_Human3.42235885
10MYB_26560356_Chip-Seq_TH2_Human3.29545436
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.89206353
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.88696551
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86106937
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60752975
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57982367
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53829915
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25873315
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.25640494
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.24772162
20MYB_26560356_Chip-Seq_TH1_Human2.23023636
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20699139
22GATA3_26560356_Chip-Seq_TH2_Human2.15414497
23SPI1_23547873_ChIP-Seq_NB4_Human2.14133006
24GATA3_27048872_Chip-Seq_THYMUS_Human2.12495275
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10840556
26MAF_26560356_Chip-Seq_TH1_Human2.10838055
27SPI1_23127762_ChIP-Seq_K562_Human1.74965718
28UTX_26944678_Chip-Seq_JUKART_Human1.74945979
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70093327
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70088379
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57655888
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55740755
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55479220
34MAF_26560356_Chip-Seq_TH2_Human1.53638888
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51725593
36SCL_19346495_ChIP-Seq_HPC-7_Human1.49382779
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.45881597
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44399883
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38087531
40CIITA_25753668_ChIP-Seq_RAJI_Human1.35931366
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34510073
42VDR_24787735_ChIP-Seq_THP-1_Human1.33206490
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.32407923
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31850431
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.25557258
46VDR_24763502_ChIP-Seq_THP-1_Human1.24641138
47GATA1_22025678_ChIP-Seq_K562_Human1.19466587
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15436332
49PU_27001747_Chip-Seq_BMDM_Mouse1.14767533
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13514212
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.12665946
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11687999
53AR_21572438_ChIP-Seq_LNCaP_Human1.09133145
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08048050
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07859538
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06766031
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05204771
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02232005
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00097990
60SMRT_27268052_Chip-Seq_Bcells_Human1.00050132
61GATA1_19941827_ChIP-Seq_MEL_Mouse0.98111084
62GATA3_26560356_Chip-Seq_TH1_Human0.98045155
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97651160
64GATA2_21666600_ChIP-Seq_HMVEC_Human0.96675194
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96190771
66PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94430903
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91488918
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91371528
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90532212
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89857545
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88225089
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86948745
73EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85332962
74PRDM14_20953172_ChIP-Seq_ESCs_Human0.84095597
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83536014
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83275623
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80994512
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79061932
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78557138
80TCF7_22412390_ChIP-Seq_EML_Mouse0.74743220
81EGR1_19032775_ChIP-ChIP_M12_Human0.74449040
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73989677
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73340772
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73298272
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72077324
86STAT1_20625510_ChIP-Seq_HELA_Human0.71851674
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71797529
88MYC_22102868_ChIP-Seq_BL_Human0.70806474
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70130678
90CEBPB_22108803_ChIP-Seq_LS180_Human0.69326818
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.69196489
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68408995
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.66902328
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66800587
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66247060
96TP63_23658742_ChIP-Seq_EP156T_Human0.66101656
97BCL6_27268052_Chip-Seq_Bcells_Human0.65973880
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65530236
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65215727
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65160766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.00122483
2MP0005671_abnormal_response_to3.98839110
3MP0001835_abnormal_antigen_presentation3.96207065
4MP0003763_abnormal_thymus_physiology3.41308512
5MP0001873_stomach_inflammation3.27493498
6MP0001800_abnormal_humoral_immune3.22287213
7MP0003436_decreased_susceptibility_to3.17169921
8MP0009785_altered_susceptibility_to3.16689676
9MP0000685_abnormal_immune_system2.97345170
10MP0009333_abnormal_splenocyte_physiolog2.93172021
11MP0005000_abnormal_immune_tolerance2.92878820
12MP0001790_abnormal_immune_system2.90280680
13MP0005387_immune_system_phenotype2.90280680
14MP0002723_abnormal_immune_serum2.63644889
15MP0004381_abnormal_hair_follicle2.61861687
16MP0002166_altered_tumor_susceptibility2.54480832
17MP0005025_abnormal_response_to2.52853806
18MP0002420_abnormal_adaptive_immunity2.49849999
19MP0002452_abnormal_antigen_presenting2.48148002
20MP0001819_abnormal_immune_cell2.48100998
21MP0002419_abnormal_innate_immunity2.47648177
22MP0000465_gastrointestinal_hemorrhage2.41551002
23MP0001853_heart_inflammation2.39778419
24MP0002148_abnormal_hypersensitivity_rea2.35699073
25MP0002405_respiratory_system_inflammati2.19157320
26MP0004947_skin_inflammation2.18380047
27MP0005075_abnormal_melanosome_morpholog2.16240627
28MP0003303_peritoneal_inflammation2.11476567
29MP0003866_abnormal_defecation2.04730042
30MP0010155_abnormal_intestine_physiology2.04292737
31MP0006082_CNS_inflammation1.97519610
32MP0002006_tumorigenesis1.92717091
33MP0002398_abnormal_bone_marrow1.92345169
34MP0000716_abnormal_immune_system1.88899030
35MP0001845_abnormal_inflammatory_respons1.79458126
36MP0001533_abnormal_skeleton_physiology1.69605575
37MP0001851_eye_inflammation1.67946137
38MP0002277_abnormal_respiratory_mucosa1.67301598
39MP0000703_abnormal_thymus_morphology1.61070850
40MP0000858_altered_metastatic_potential1.60479890
41MP0000689_abnormal_spleen_morphology1.55560216
42MP0003300_gastrointestinal_ulcer1.54795408
43MP0009764_decreased_sensitivity_to1.54556917
44MP0002722_abnormal_immune_system1.51154670
45MP0005310_abnormal_salivary_gland1.45873814
46MP0002429_abnormal_blood_cell1.42610285
47MP0003172_abnormal_lysosome_physiology1.40984158
48MP0005464_abnormal_platelet_physiology1.38345636
49MP0002396_abnormal_hematopoietic_system1.37495398
50MP0003191_abnormal_cellular_cholesterol1.28231839
51MP0008260_abnormal_autophagy1.27223145
52MP0008469_abnormal_protein_level1.19427209
53MP0003448_altered_tumor_morphology1.12248316
54MP0000579_abnormal_nail_morphology1.08834766
55MP0009763_increased_sensitivity_to1.03514276
56MP0001663_abnormal_digestive_system0.97962070
57MP0004883_abnormal_blood_vessel0.97767144
58MP0000569_abnormal_digit_pigmentation0.96234814
59MP0001986_abnormal_taste_sensitivity0.94420483
60MP0003075_altered_response_to0.93994684
61MP0002796_impaired_skin_barrier0.92657639
62MP0003045_fibrosis0.90436652
63MP0005397_hematopoietic_system_phenotyp0.88857830
64MP0001545_abnormal_hematopoietic_system0.88857830
65MP0004484_altered_response_of0.86695779
66MP0002933_joint_inflammation0.81869440
67MP0002009_preneoplasia0.81799295
68MP0002998_abnormal_bone_remodeling0.81363750
69MP0005166_decreased_susceptibility_to0.76215358
70MP0002132_abnormal_respiratory_system0.73717201
71MP0002098_abnormal_vibrissa_morphology0.71229282
72MP0005164_abnormal_response_to0.71130286
73MP0001919_abnormal_reproductive_system0.69460546
74MP0002138_abnormal_hepatobiliary_system0.69101974
75MP0004510_myositis0.69026522
76MP0003828_pulmonary_edema0.67750160
77MP0003656_abnormal_erythrocyte_physiolo0.67513920
78MP0000604_amyloidosis0.66252364
79MP0005275_abnormal_skin_tensile0.65053552
80MP0003221_abnormal_cardiomyocyte_apopto0.64673540
81MP0008004_abnormal_stomach_pH0.63168285
82MP0009278_abnormal_bone_marrow0.62207461
83MP0005390_skeleton_phenotype0.61738435
84MP0000249_abnormal_blood_vessel0.58784306
85MP0005451_abnormal_body_composition0.58152214
86MP0002019_abnormal_tumor_incidence0.57905125
87MP0009765_abnormal_xenobiotic_induced0.56434812
88MP0000490_abnormal_crypts_of0.56043304
89MP0000343_altered_response_to0.55731493
90MP0005377_hearing/vestibular/ear_phenot0.53645379
91MP0003878_abnormal_ear_physiology0.53645379
92MP0005381_digestive/alimentary_phenotyp0.52575526
93MP0003091_abnormal_cell_migration0.52235227
94MP0003806_abnormal_nucleotide_metabolis0.50839430
95MP0005058_abnormal_lysosome_morphology0.48665278
96MP0001216_abnormal_epidermal_layer0.48450163
97MP0004130_abnormal_muscle_cell0.46887967
98MP0002095_abnormal_skin_pigmentation0.46804077
99MP0002638_abnormal_pupillary_reflex0.46758012
100MP0003453_abnormal_keratinocyte_physiol0.46193488

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)7.09501483
2Stomatitis (HP:0010280)5.55634266
3Myositis (HP:0100614)5.50358402
4T lymphocytopenia (HP:0005403)5.35138763
5Abnormality of T cell number (HP:0011839)5.27128611
6Eczematoid dermatitis (HP:0000976)4.89374544
7Autoimmune hemolytic anemia (HP:0001890)4.76477488
8Orchitis (HP:0100796)4.64550288
9Retrobulbar optic neuritis (HP:0100654)4.54165196
10Optic neuritis (HP:0100653)4.54165196
11Recurrent bacterial skin infections (HP:0005406)4.45652086
12Recurrent abscess formation (HP:0002722)4.23952718
13Chronic mucocutaneous candidiasis (HP:0002728)3.96340509
14Recurrent cutaneous fungal infections (HP:0011370)3.96340509
15Abnormality of T cells (HP:0002843)3.87543803
16Keratoconjunctivitis sicca (HP:0001097)3.81310367
17Recurrent fungal infections (HP:0002841)3.78674329
18Severe combined immunodeficiency (HP:0004430)3.77467209
19IgG deficiency (HP:0004315)3.71177221
20Pulmonary infiltrates (HP:0002113)3.70284871
21Pustule (HP:0200039)3.63162953
22Increased IgM level (HP:0003496)3.60746401
23Vasculitis (HP:0002633)3.60043454
24Recurrent skin infections (HP:0001581)3.57419943
25Gangrene (HP:0100758)3.56448709
26Keratoconjunctivitis (HP:0001096)3.50460844
27Gastrointestinal infarctions (HP:0005244)3.49607826
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.47652639
29Leukocytosis (HP:0001974)3.43689823
30Abnormality of eosinophils (HP:0001879)3.38335334
31Hemoptysis (HP:0002105)3.37924485
32Mediastinal lymphadenopathy (HP:0100721)3.29987568
33Abnormality of macrophages (HP:0004311)3.26399289
34Meningitis (HP:0001287)3.23697114
35Recurrent bronchitis (HP:0002837)3.15165520
36Chronic obstructive pulmonary disease (HP:0006510)3.13779668
37Obstructive lung disease (HP:0006536)3.13779668
38Chest pain (HP:0100749)3.07993957
39Increased IgE level (HP:0003212)2.97438381
40Encephalitis (HP:0002383)2.93759998
41Urticaria (HP:0001025)2.87787518
42Combined immunodeficiency (HP:0005387)2.87192357
43Thyroiditis (HP:0100646)2.85579011
44Hypergammaglobulinemia (HP:0010702)2.85263616
45Pulmonary embolism (HP:0002204)2.76497286
46Eosinophilia (HP:0001880)2.76422882
47Abnormality of secondary sexual hair (HP:0009888)2.72708180
48Abnormality of the axillary hair (HP:0100134)2.72708180
49Abnormality of the pleura (HP:0002103)2.71933058
50Abnormality of T cell physiology (HP:0011840)2.67754857
51Chronic diarrhea (HP:0002028)2.64000338
52Recurrent gram-negative bacterial infections (HP:0005420)2.62023610
53Abnormality of the prostate (HP:0008775)2.61179536
54Gingivitis (HP:0000230)2.58959118
55Granulocytopenia (HP:0001913)2.55634316
56Stomach cancer (HP:0012126)2.55160881
57Erythema (HP:0010783)2.52851241
58Peritonitis (HP:0002586)2.50175228
59Spontaneous hematomas (HP:0007420)2.47101550
60Thick nail (HP:0001805)2.46782092
61Inflammation of the large intestine (HP:0002037)2.45217327
62Epistaxis (HP:0000421)2.37085060
63Arterial thrombosis (HP:0004420)2.35861475
64Recurrent viral infections (HP:0004429)2.33758323
65IgM deficiency (HP:0002850)2.32644047
66Abnormality of nail color (HP:0100643)2.26427474
67Polyneuropathy (HP:0001271)2.24227868
68Gastrointestinal inflammation (HP:0004386)2.22755131
69Ureteral stenosis (HP:0000071)2.22419164
70Skin rash (HP:0000988)2.22367831
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18292749
72Ureteral obstruction (HP:0006000)2.17020335
73Colitis (HP:0002583)2.14302309
74Panhypogammaglobulinemia (HP:0003139)2.14002394
75Gingival bleeding (HP:0000225)2.13174001
76Hypoplasia of the thymus (HP:0000778)2.12197037
77Abnormality of the pericardium (HP:0001697)2.11310137
78Alveolar cell carcinoma (HP:0006519)2.09211338
79Sepsis (HP:0100806)2.07741800
80Glomerulopathy (HP:0100820)2.05572870
81Joint swelling (HP:0001386)2.03374760
82Skin ulcer (HP:0200042)2.03304901
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03024159
84Autoimmune thrombocytopenia (HP:0001973)2.01236747
85Anorexia (HP:0002039)2.00007723
86Abnormality of cells of the lymphoid lineage (HP:0012140)1.98450174
87Neoplasm of the tracheobronchial system (HP:0100552)1.96845504
88Fatigue (HP:0012378)1.96214386
89Onycholysis (HP:0001806)1.95930520
90Woolly hair (HP:0002224)1.93991313
91Agammaglobulinemia (HP:0004432)1.92136956
92Keratitis (HP:0000491)1.91593085
93Pili torti (HP:0003777)1.91037211
94Thrombophlebitis (HP:0004418)1.90384092
95Lymphopenia (HP:0001888)1.89413995
96Pruritus (HP:0000989)1.88286700
97Hypochromic anemia (HP:0001931)1.86388075
98Episodic fever (HP:0001954)1.85664120
99Aplastic anemia (HP:0001915)1.84088832
100Petechiae (HP:0000967)1.84036580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.18845117
2TYK23.55267722
3MAP4K13.12923812
4SCYL22.95792948
5JAK12.69966386
6FES2.62619497
7JAK32.59876545
8GRK62.43725220
9IRAK42.38930648
10TAOK32.33329407
11RIPK42.32290900
12TEC2.18302130
13ITK2.16428433
14CSK2.13179755
15IKBKE2.09254677
16MAP3K141.93409646
17FGFR41.91539503
18BTK1.87573679
19CDK191.82943089
20BLK1.82781767
21BMPR21.80301491
22NLK1.75693816
23KIT1.69784203
24ZAP701.68830645
25FGR1.59218658
26FGFR31.57900470
27NUAK11.56629249
28SYK1.51117403
29LCK1.48544580
30PDK21.47961034
31JAK21.47931750
32CSF1R1.46490864
33ERN11.43068205
34CAMKK21.38739533
35HCK1.36411742
36MAP3K131.35817519
37SIK31.35116064
38MAP2K31.31935662
39LYN1.24070981
40TBK11.23495143
41IKBKB1.08640862
42MARK31.08609412
43MAP3K11.03517820
44EPHB11.02568596
45AKT30.95161980
46MAP3K30.93666243
47TNK20.93547440
48NEK90.91768600
49LRRK20.88689475
50HIPK20.87577701
51RPS6KA40.85158142
52WNK10.78648364
53TIE10.75531266
54MST40.73668407
55MAP3K60.72824106
56MAP3K120.69890814
57MAP2K60.68707533
58SGK20.67714811
59PIK3CG0.67365210
60MAPKAPK30.62365815
61IRAK10.61982489
62TAOK10.61973316
63LATS10.60637102
64EPHA30.60597907
65PIM10.57841502
66FYN0.55354921
67NEK60.54974181
68PDK10.53150767
69PRPF4B0.53021485
70PRKCQ0.50524073
71CLK10.50486235
72SGK30.49649477
73ADRBK20.46632128
74TLK10.46225863
75STK100.45611277
76GRK70.44571030
77STK240.44117937
78STK380.42945042
79PTK2B0.40625986
80FRK0.40238698
81MAPKAPK20.37753932
82MATK0.37265211
83MAPK120.35546824
84CAMKK10.34596313
85STK38L0.34348490
86SGK4940.33627538
87SGK2230.33627538
88TRPM70.32024643
89ABL10.31928713
90YES10.30275562
91EGFR0.29814264
92MAPK110.28033048
93IGF1R0.27953913
94PDPK10.27569903
95CHUK0.27252040
96TYRO30.26957773
97RPS6KA50.26575453
98MAP3K20.24999507
99TAOK20.23861539
100STK110.19080922

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.05158416
2Allograft rejection_Homo sapiens_hsa053303.88489002
3Graft-versus-host disease_Homo sapiens_hsa053323.60242916
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.29220101
5Primary immunodeficiency_Homo sapiens_hsa053403.26941256
6Staphylococcus aureus infection_Homo sapiens_hsa051503.10553704
7Type I diabetes mellitus_Homo sapiens_hsa049402.97960299
8Leishmaniasis_Homo sapiens_hsa051402.92416555
9Asthma_Homo sapiens_hsa053102.90332576
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.60978090
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34967270
12T cell receptor signaling pathway_Homo sapiens_hsa046602.31605599
13Antigen processing and presentation_Homo sapiens_hsa046122.26352758
14Osteoclast differentiation_Homo sapiens_hsa043802.17492449
15Measles_Homo sapiens_hsa051622.15073513
16Viral myocarditis_Homo sapiens_hsa054162.05187039
17Hematopoietic cell lineage_Homo sapiens_hsa046402.02959558
18Toxoplasmosis_Homo sapiens_hsa051451.93848139
19Tuberculosis_Homo sapiens_hsa051521.85097382
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74732507
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.64929272
22Influenza A_Homo sapiens_hsa051641.61327331
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.55376608
24Herpes simplex infection_Homo sapiens_hsa051681.50955818
25Rheumatoid arthritis_Homo sapiens_hsa053231.49563885
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48122341
27B cell receptor signaling pathway_Homo sapiens_hsa046621.46673177
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46317427
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45823287
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34741876
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34112070
32Malaria_Homo sapiens_hsa051441.33834077
33Chemokine signaling pathway_Homo sapiens_hsa040621.29775722
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15889331
35TNF signaling pathway_Homo sapiens_hsa046681.08443756
36Legionellosis_Homo sapiens_hsa051341.03624268
37Hepatitis B_Homo sapiens_hsa051611.01400939
38Phagosome_Homo sapiens_hsa041450.99032145
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95889472
40Acute myeloid leukemia_Homo sapiens_hsa052210.94948751
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93288748
42Platelet activation_Homo sapiens_hsa046110.93213261
43African trypanosomiasis_Homo sapiens_hsa051430.89249378
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.77653974
45Hepatitis C_Homo sapiens_hsa051600.75258514
46Pertussis_Homo sapiens_hsa051330.70551354
47Apoptosis_Homo sapiens_hsa042100.70354103
48Epstein-Barr virus infection_Homo sapiens_hsa051690.61829130
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61681753
50Glycerolipid metabolism_Homo sapiens_hsa005610.59365205
51VEGF signaling pathway_Homo sapiens_hsa043700.57290166
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55096016
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53086512
54Regulation of autophagy_Homo sapiens_hsa041400.53052423
55ABC transporters_Homo sapiens_hsa020100.52768496
56HTLV-I infection_Homo sapiens_hsa051660.52645098
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51586275
58Nitrogen metabolism_Homo sapiens_hsa009100.50726838
59Shigellosis_Homo sapiens_hsa051310.49995501
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.49066136
61Non-small cell lung cancer_Homo sapiens_hsa052230.48629483
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46389756
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44083886
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42755155
65Pancreatic cancer_Homo sapiens_hsa052120.42711759
66Dorso-ventral axis formation_Homo sapiens_hsa043200.42575870
67FoxO signaling pathway_Homo sapiens_hsa040680.39208486
68Prolactin signaling pathway_Homo sapiens_hsa049170.38035345
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36561151
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36254730
71Salmonella infection_Homo sapiens_hsa051320.36151138
72Endocytosis_Homo sapiens_hsa041440.35096192
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33637167
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33333302
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.32123111
76Viral carcinogenesis_Homo sapiens_hsa052030.28032365
77Circadian rhythm_Homo sapiens_hsa047100.27773261
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.27172788
79Amoebiasis_Homo sapiens_hsa051460.26610126
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25682649
81Insulin resistance_Homo sapiens_hsa049310.25147241
82Inositol phosphate metabolism_Homo sapiens_hsa005620.24517085
83Lysosome_Homo sapiens_hsa041420.24481753
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23637631
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23414309
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.22783195
87Linoleic acid metabolism_Homo sapiens_hsa005910.20030686
88Systemic lupus erythematosus_Homo sapiens_hsa053220.19401709
89MAPK signaling pathway_Homo sapiens_hsa040100.18495906
90GnRH signaling pathway_Homo sapiens_hsa049120.18130732
91Collecting duct acid secretion_Homo sapiens_hsa049660.17072842
92Olfactory transduction_Homo sapiens_hsa047400.15475178
93Thyroid cancer_Homo sapiens_hsa052160.15135683
94Fatty acid biosynthesis_Homo sapiens_hsa000610.15075559
95Choline metabolism in cancer_Homo sapiens_hsa052310.14585738
96HIF-1 signaling pathway_Homo sapiens_hsa040660.12703255
97Pancreatic secretion_Homo sapiens_hsa049720.12170887
98Colorectal cancer_Homo sapiens_hsa052100.12158953
99Complement and coagulation cascades_Homo sapiens_hsa046100.11640504
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11107451

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