CASP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.49760512
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.49760512
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45360107
4response to peptidoglycan (GO:0032494)4.74600291
5neutrophil activation involved in immune response (GO:0002283)4.56060314
6regulation of B cell receptor signaling pathway (GO:0050855)4.38466899
7type I interferon signaling pathway (GO:0060337)4.32777809
8cellular response to type I interferon (GO:0071357)4.32777809
9response to type I interferon (GO:0034340)4.29517596
10positive regulation by symbiont of host defense response (GO:0052509)4.28954631
11modulation by symbiont of host defense response (GO:0052031)4.28954631
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28954631
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28954631
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.28954631
15modulation by symbiont of host immune response (GO:0052553)4.28954631
16negative regulation of interleukin-12 production (GO:0032695)4.26888019
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24084806
18positive regulation of interferon-alpha production (GO:0032727)4.19789797
19regulation of gamma-delta T cell activation (GO:0046643)4.18271345
20positive regulation of antigen processing and presentation (GO:0002579)4.06312534
21regulation of interferon-alpha production (GO:0032647)3.99946521
22regulation of T-helper 1 cell differentiation (GO:0045625)3.98453778
23negative regulation of viral genome replication (GO:0045071)3.97933135
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.96773375
25response to interferon-alpha (GO:0035455)3.94243589
26regulation of RIG-I signaling pathway (GO:0039535)3.86152574
27defense response to protozoan (GO:0042832)3.83680232
28leukocyte aggregation (GO:0070486)3.80540249
29regulation of gamma-delta T cell differentiation (GO:0045586)3.80375252
30positive regulation of natural killer cell differentiation (GO:0032825)3.79289970
31response to interferon-beta (GO:0035456)3.78632171
32positive regulation of gamma-delta T cell activation (GO:0046645)3.77383670
33detection of external biotic stimulus (GO:0098581)3.77169185
34superoxide anion generation (GO:0042554)3.75669076
35regulation of activation of Janus kinase activity (GO:0010533)3.73732672
36antigen processing and presentation of endogenous antigen (GO:0019883)3.72957399
37NIK/NF-kappaB signaling (GO:0038061)3.71547050
38neutrophil activation (GO:0042119)3.66133831
39granulocyte activation (GO:0036230)3.66030629
40cellular response to interferon-beta (GO:0035458)3.63295926
41immunoglobulin mediated immune response (GO:0016064)3.59203973
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.59187174
43cellular extravasation (GO:0045123)3.59062710
44positive regulation of interleukin-12 production (GO:0032735)3.54039825
45regulation of antigen processing and presentation (GO:0002577)3.50490197
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50312195
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50312195
48microglial cell activation (GO:0001774)3.49915505
49response to protozoan (GO:0001562)3.49555534
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.49203081
51myeloid dendritic cell activation (GO:0001773)3.49061134
52response to interleukin-15 (GO:0070672)3.47031551
53response to muramyl dipeptide (GO:0032495)3.46230124
54interferon-gamma-mediated signaling pathway (GO:0060333)3.45153706
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44696793
56response to host immune response (GO:0052572)3.44696793
57positive regulation of type 2 immune response (GO:0002830)3.44349116
58myeloid dendritic cell differentiation (GO:0043011)3.42958408
59respiratory burst (GO:0045730)3.39952594
60macrophage activation involved in immune response (GO:0002281)3.38793275
61negative regulation of T cell mediated immunity (GO:0002710)3.37455176
62regulation of regulatory T cell differentiation (GO:0045589)3.35974506
63positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.35876550
64positive regulation of cellular amide metabolic process (GO:0034250)3.35673965
65regulation of interleukin-12 biosynthetic process (GO:0045075)3.35574034
66regulation of chemokine biosynthetic process (GO:0045073)3.35572373
67positive regulation of heat generation (GO:0031652)3.31407220
68positive regulation of interleukin-17 production (GO:0032740)3.30255589
69regulation of T cell tolerance induction (GO:0002664)3.29027911
70detection of biotic stimulus (GO:0009595)3.28789420
71T-helper 1 type immune response (GO:0042088)3.27340220
72cellular response to interleukin-15 (GO:0071350)3.26277505
73macrophage activation (GO:0042116)3.24211412
74positive regulation of T-helper cell differentiation (GO:0045624)3.24004717
75positive thymic T cell selection (GO:0045059)3.23816828
76regulation of tolerance induction (GO:0002643)3.23647511
77regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.23322938
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22577640
79detection of other organism (GO:0098543)3.21291779
80regulation of interferon-beta biosynthetic process (GO:0045357)3.20753616
81negative regulation of leukocyte mediated immunity (GO:0002704)3.20293531
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19070181
83hydrogen peroxide biosynthetic process (GO:0050665)3.18600977
84positive regulation of interferon-beta production (GO:0032728)3.18208398
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.15064891
86positive regulation of B cell differentiation (GO:0045579)3.14574947
87cellular response to exogenous dsRNA (GO:0071360)3.14182307
88negative T cell selection (GO:0043383)3.13329581
89regulation of T cell mediated cytotoxicity (GO:0001914)3.13043684
90regulation of fever generation (GO:0031620)3.13017939
91detection of molecule of bacterial origin (GO:0032490)3.12065051
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11993181
93positive regulation of chemokine biosynthetic process (GO:0045080)3.11720679
94myeloid cell activation involved in immune response (GO:0002275)3.11387460
95production of molecular mediator involved in inflammatory response (GO:0002532)3.11329701
96antigen processing and presentation via MHC class Ib (GO:0002475)3.10944470
97positive regulation of interleukin-1 beta secretion (GO:0050718)3.09904764
98negative thymic T cell selection (GO:0045060)3.08813871
99B cell receptor signaling pathway (GO:0050853)3.08474177
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05957984
101response to host (GO:0075136)3.05957984
102response to host defenses (GO:0052200)3.05957984
103regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.05180468
104regulation of interleukin-17 production (GO:0032660)3.02930164
105monocyte chemotaxis (GO:0002548)3.02145452
106positive regulation of tolerance induction (GO:0002645)3.01965470
107dendritic cell chemotaxis (GO:0002407)3.01174237
108regulation of mast cell degranulation (GO:0043304)3.00903467
109reactive oxygen species biosynthetic process (GO:1903409)2.99320432
110neutrophil mediated immunity (GO:0002446)2.96499163
111positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96477637
112dendritic cell differentiation (GO:0097028)2.95239055
113germinal center formation (GO:0002467)2.94784267
114natural killer cell mediated cytotoxicity (GO:0042267)2.94713217
115natural killer cell mediated immunity (GO:0002228)2.94713217
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94704829
117regulation of interleukin-1 beta secretion (GO:0050706)2.94299029
118positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93838575
119regulation of B cell differentiation (GO:0045577)2.92489263
120regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92080186
121regulation of natural killer cell mediated immunity (GO:0002715)2.92080186
122regulation of alpha-beta T cell proliferation (GO:0046640)2.91848397
123regulation of interleukin-12 production (GO:0032655)2.90062207
124detection of bacterium (GO:0016045)2.88902675
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88674044
126negative regulation of innate immune response (GO:0045824)2.87999927
127tolerance induction (GO:0002507)2.87611429
128positive T cell selection (GO:0043368)2.87575175
129positive regulation of interleukin-1 secretion (GO:0050716)2.86694098
130T cell migration (GO:0072678)2.86150039
131B cell mediated immunity (GO:0019724)2.85835545
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85693747
133positive regulation of defense response to virus by host (GO:0002230)2.85622717
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85485433
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84883041
136cellular response to zinc ion (GO:0071294)2.84352615
137positive regulation of interleukin-10 production (GO:0032733)2.84234105
138negative regulation of interleukin-17 production (GO:0032700)2.84114664
139negative regulation of T-helper cell differentiation (GO:0045623)2.84048647
140negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84048647
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84023055
142myeloid leukocyte activation (GO:0002274)2.83680488
143regulation of immunoglobulin secretion (GO:0051023)2.83403195
144regulation of mast cell activation (GO:0033003)2.83397951
145regulation of T-helper 2 cell differentiation (GO:0045628)2.78839575
146regulation of mast cell activation involved in immune response (GO:0033006)2.77988186
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77542551
148leukocyte degranulation (GO:0043299)2.77021679
149cellular response to interferon-gamma (GO:0071346)2.75628847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.39783115
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.22919023
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.82500225
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.11861248
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.92951953
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36430327
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.93156058
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.63357208
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63329600
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16680543
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14006126
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01822403
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00390774
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.99549799
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96705008
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75560124
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56438732
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.51213665
19SCL_19346495_ChIP-Seq_HPC-7_Human2.20902226
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13665141
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.07333805
22GATA1_22025678_ChIP-Seq_K562_Human2.02136508
23SPI1_23547873_ChIP-Seq_NB4_Human1.89196719
24RUNX_20019798_ChIP-Seq_JUKART_Human1.84235490
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70176395
26UTX_26944678_Chip-Seq_JUKART_Human1.68779433
27MYB_26560356_Chip-Seq_TH2_Human1.68726958
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65880698
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64723805
30PU_27001747_Chip-Seq_BMDM_Mouse1.64145100
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62330239
32VDR_21846776_ChIP-Seq_THP-1_Human1.57565741
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.56079731
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.53812560
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53574228
36VDR_24787735_ChIP-Seq_THP-1_Human1.53180006
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.48854885
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47701105
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46556178
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43546224
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41293570
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39932807
43MYB_26560356_Chip-Seq_TH1_Human1.38605531
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37758743
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34379716
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32942524
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32597757
48* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32293084
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31904893
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.31080807
51VDR_24763502_ChIP-Seq_THP-1_Human1.30930187
52MAF_26560356_Chip-Seq_TH2_Human1.29723779
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.27861909
54* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21714929
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19107357
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17649592
57GATA3_26560356_Chip-Seq_TH2_Human1.17045881
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14985556
59SPI1_23127762_ChIP-Seq_K562_Human1.14696675
60MAF_26560356_Chip-Seq_TH1_Human1.13023101
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12922738
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12017126
63TCF7_22412390_ChIP-Seq_EML_Mouse1.11466890
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10389450
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09527008
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07502739
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07502049
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07405083
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07359526
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05856571
71GATA1_19941826_ChIP-Seq_K562_Human1.05479212
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03731851
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.03455206
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03171108
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03019952
76* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02845345
77MYC_22102868_ChIP-Seq_BL_Human1.00470525
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00049027
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99510764
80* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99171532
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98663709
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98499328
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94979558
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.93635343
85* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93553526
86GATA3_27048872_Chip-Seq_THYMUS_Human0.93205656
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93091016
88GATA2_19941826_ChIP-Seq_K562_Human0.93011806
89* ELK3_25401928_ChIP-Seq_HUVEC_Human0.90042197
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.89440070
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89369967
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88819729
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88819729
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88717802
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86403424
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84913356
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83951803
98PU1_27457419_Chip-Seq_LIVER_Mouse0.83671737
99* SOX2_20726797_ChIP-Seq_SW620_Human0.83509652
100EGR1_19032775_ChIP-ChIP_M12_Human0.82789190
101STAT1_20625510_ChIP-Seq_HELA_Human0.82785927
102KDM2B_26808549_Chip-Seq_DND41_Human0.81891034
103SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80980879
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.80813469
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79880557
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79270383
107BCL6_27268052_Chip-Seq_Bcells_Human0.78651941
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78467768
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78344687
110NMYC_18555785_Chip-Seq_ESCs_Mouse0.78268068
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77876257
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77692165
113P53_22387025_ChIP-Seq_ESCs_Mouse0.76898547
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76765126
115SMRT_27268052_Chip-Seq_Bcells_Human0.76724764
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76364286
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76144559
118PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76118002
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74458094
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73286832
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72989303
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72989303
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.72610272
124HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72574819
125CJUN_26792858_Chip-Seq_BT549_Human0.72248356
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71724993
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71597253
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.70716563
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.70608753
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69980550
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.69507305
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67923770
133SPI1_20517297_ChIP-Seq_HL60_Human0.67844800
134BCOR_27268052_Chip-Seq_Bcells_Human0.67401430
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66257213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.95384702
2MP0009785_altered_susceptibility_to4.20217607
3MP0002148_abnormal_hypersensitivity_rea3.78642366
4MP0000685_abnormal_immune_system3.57610715
5MP0003724_increased_susceptibility_to3.53598389
6MP0003436_decreased_susceptibility_to3.39462827
7MP0005671_abnormal_response_to3.18833067
8MP0005000_abnormal_immune_tolerance3.14290262
9MP0001790_abnormal_immune_system3.13142761
10MP0005387_immune_system_phenotype3.13142761
11MP0005025_abnormal_response_to3.09642117
12MP0006082_CNS_inflammation3.06991397
13MP0002419_abnormal_innate_immunity2.99542291
14MP0001800_abnormal_humoral_immune2.73357465
15MP0002452_abnormal_antigen_presenting2.70842590
16* MP0002723_abnormal_immune_serum2.58739712
17MP0001819_abnormal_immune_cell2.35008704
18MP0002420_abnormal_adaptive_immunity2.31615681
19MP0004510_myositis2.13354767
20MP0009764_decreased_sensitivity_to2.06265141
21MP0005464_abnormal_platelet_physiology2.01088279
22MP0010155_abnormal_intestine_physiology1.99730456
23MP0002254_reproductive_system_inflammat1.94376264
24MP0001853_heart_inflammation1.92661095
25MP0002405_respiratory_system_inflammati1.89622620
26MP0004947_skin_inflammation1.87782094
27MP0002006_tumorigenesis1.86312406
28MP0001533_abnormal_skeleton_physiology1.83020057
29* MP0001845_abnormal_inflammatory_respons1.82721438
30MP0003303_peritoneal_inflammation1.82576124
31MP0000716_abnormal_immune_system1.72763365
32MP0002277_abnormal_respiratory_mucosa1.67984940
33MP0002398_abnormal_bone_marrow1.67901857
34MP0003763_abnormal_thymus_physiology1.66585713
35MP0009278_abnormal_bone_marrow1.60284230
36MP0005397_hematopoietic_system_phenotyp1.59751431
37MP0001545_abnormal_hematopoietic_system1.59751431
38MP0000569_abnormal_digit_pigmentation1.56168204
39MP0005310_abnormal_salivary_gland1.56040055
40MP0002166_altered_tumor_susceptibility1.55537173
41MP0003448_altered_tumor_morphology1.51447152
42* MP0008469_abnormal_protein_level1.51025854
43MP0005451_abnormal_body_composition1.43711031
44MP0000343_altered_response_to1.41170107
45MP0002429_abnormal_blood_cell1.36354486
46MP0009333_abnormal_splenocyte_physiolog1.35997606
47MP0002396_abnormal_hematopoietic_system1.35779119
48MP0001873_stomach_inflammation1.35328896
49MP0004808_abnormal_hematopoietic_stem1.34046378
50MP0004782_abnormal_surfactant_physiolog1.31462598
51MP0005058_abnormal_lysosome_morphology1.31149631
52MP0003806_abnormal_nucleotide_metabolis1.27995493
53MP0002998_abnormal_bone_remodeling1.27792407
54MP0000858_altered_metastatic_potential1.27348241
55MP0000689_abnormal_spleen_morphology1.27257543
56MP0005174_abnormal_tail_pigmentation1.25568545
57MP0004883_abnormal_blood_vessel1.25539285
58MP0002722_abnormal_immune_system1.23161759
59MP0002138_abnormal_hepatobiliary_system1.20151248
60MP0003075_altered_response_to1.18915401
61MP0003828_pulmonary_edema1.11354551
62MP0003191_abnormal_cellular_cholesterol1.11335903
63MP0006054_spinal_hemorrhage1.08538886
64MP0004381_abnormal_hair_follicle1.08384459
65MP0003172_abnormal_lysosome_physiology1.00109825
66MP0005390_skeleton_phenotype0.99996835
67MP0005166_decreased_susceptibility_to0.97342303
68MP0005164_abnormal_response_to0.96157710
69MP0009763_increased_sensitivity_to0.95341082
70MP0003656_abnormal_erythrocyte_physiolo0.94832478
71MP0000604_amyloidosis0.92873365
72MP0003300_gastrointestinal_ulcer0.91365683
73MP0000015_abnormal_ear_pigmentation0.90494379
74MP0001346_abnormal_lacrimal_gland0.89712500
75MP0003186_abnormal_redox_activity0.89453100
76MP0002933_joint_inflammation0.89091973
77MP0009840_abnormal_foam_cell0.88973151
78MP0001348_abnormal_lacrimal_gland0.88920897
79MP0000490_abnormal_crypts_of0.88524534
80MP0001851_eye_inflammation0.85677487
81MP0002876_abnormal_thyroid_physiology0.85115276
82MP0002132_abnormal_respiratory_system0.84914114
83MP0003183_abnormal_peptide_metabolism0.83598076
84MP0002332_abnormal_exercise_endurance0.80674536
85MP0000465_gastrointestinal_hemorrhage0.80492741
86MP0000703_abnormal_thymus_morphology0.80483621
87MP0003866_abnormal_defecation0.79928740
88MP0003690_abnormal_glial_cell0.79230219
89MP0010307_abnormal_tumor_latency0.78426492
90MP0000371_diluted_coat_color0.77895938
91MP0005167_abnormal_blood-brain_barrier0.75002694
92MP0003045_fibrosis0.72445466
93MP0008260_abnormal_autophagy0.71363090
94MP0003453_abnormal_keratinocyte_physiol0.69993473
95MP0005075_abnormal_melanosome_morpholog0.67619336
96MP0002877_abnormal_melanocyte_morpholog0.67059999
97MP0001986_abnormal_taste_sensitivity0.67050391
98MP0003091_abnormal_cell_migration0.65829389
99MP0001879_abnormal_lymphatic_vessel0.62230307
100MP0003252_abnormal_bile_duct0.61912439
101MP0002163_abnormal_gland_morphology0.61470306
102MP0000249_abnormal_blood_vessel0.61402889
103MP0005165_increased_susceptibility_to0.59695840
104MP0008874_decreased_physiological_sensi0.59544238
105MP0005023_abnormal_wound_healing0.58218231
106MP0001191_abnormal_skin_condition0.57738905
107MP0001881_abnormal_mammary_gland0.57677400
108MP0005319_abnormal_enzyme/_coenzyme0.56937707
109MP0009765_abnormal_xenobiotic_induced0.56760424
110MP0003795_abnormal_bone_structure0.56378251
111MP0001501_abnormal_sleep_pattern0.56317290
112MP0001663_abnormal_digestive_system0.54946461
113MP0010352_gastrointestinal_tract_polyps0.54904483
114MP0000767_abnormal_smooth_muscle0.53656079
115MP0000609_abnormal_liver_physiology0.53467831
116MP0008004_abnormal_stomach_pH0.53151523
117MP0003943_abnormal_hepatobiliary_system0.51982495
118MP0002136_abnormal_kidney_physiology0.51090163

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.30225000
2Recurrent abscess formation (HP:0002722)5.99051596
3Recurrent bacterial skin infections (HP:0005406)5.60853573
4Mediastinal lymphadenopathy (HP:0100721)4.72866879
5Myositis (HP:0100614)4.62411484
6Elevated erythrocyte sedimentation rate (HP:0003565)4.53947200
7Recurrent gram-negative bacterial infections (HP:0005420)4.53495621
8Optic neuritis (HP:0100653)4.47275457
9Retrobulbar optic neuritis (HP:0100654)4.47275457
10Orchitis (HP:0100796)4.47048937
11Autoimmune thrombocytopenia (HP:0001973)4.32653865
12Abnormality of macrophages (HP:0004311)4.24383311
13Increased IgM level (HP:0003496)4.10324479
14Recurrent fungal infections (HP:0002841)4.09073540
15Recurrent skin infections (HP:0001581)3.80323769
16Vasculitis (HP:0002633)3.78088383
17Gingivitis (HP:0000230)3.59770725
18Prostate neoplasm (HP:0100787)3.56862499
19Stomatitis (HP:0010280)3.54891889
20Recurrent cutaneous fungal infections (HP:0011370)3.50036676
21Chronic mucocutaneous candidiasis (HP:0002728)3.50036676
22Obstructive lung disease (HP:0006536)3.32419211
23Chronic obstructive pulmonary disease (HP:0006510)3.32419211
24Recurrent viral infections (HP:0004429)3.30659407
25Chronic otitis media (HP:0000389)3.20987941
26Pulmonary infiltrates (HP:0002113)3.17607539
27Periodontitis (HP:0000704)3.16533905
28Basal ganglia calcification (HP:0002135)3.16219922
29Vacuolated lymphocytes (HP:0001922)3.15311455
30Cellulitis (HP:0100658)3.04795915
31Meningitis (HP:0001287)3.02610906
32Abnormality of liposaccharide metabolism (HP:0010968)2.99406045
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.99406045
34Abnormality of glycolipid metabolism (HP:0010969)2.99406045
35Hypergammaglobulinemia (HP:0010702)2.97255030
36Pustule (HP:0200039)2.93560506
37Keratoconjunctivitis (HP:0001096)2.91325599
38Interstitial pulmonary disease (HP:0006530)2.90064834
39Chest pain (HP:0100749)2.89123457
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.87438352
41Systemic lupus erythematosus (HP:0002725)2.84869867
42Recurrent pneumonia (HP:0006532)2.82632041
43Abnormality of the prostate (HP:0008775)2.78407437
44Arterial thrombosis (HP:0004420)2.73935911
45Eosinophilia (HP:0001880)2.69324461
46Keratoconjunctivitis sicca (HP:0001097)2.69208411
47Hemoptysis (HP:0002105)2.67615912
48Leukocytosis (HP:0001974)2.64838823
49Osteomyelitis (HP:0002754)2.63759487
50Gingival bleeding (HP:0000225)2.62961181
51Pulmonary embolism (HP:0002204)2.59991990
52Peritonitis (HP:0002586)2.58290165
53Recurrent lower respiratory tract infections (HP:0002783)2.54891457
54Petechiae (HP:0000967)2.53014792
55Agammaglobulinemia (HP:0004432)2.52943281
56Urticaria (HP:0001025)2.52622418
57Recurrent bronchitis (HP:0002837)2.50291985
58Thrombocytosis (HP:0001894)2.49671241
59Tetraparesis (HP:0002273)2.46790008
60Thick nail (HP:0001805)2.45996113
61Autoimmune hemolytic anemia (HP:0001890)2.43967335
62Abnormality of B cell number (HP:0010975)2.43780537
63Granulocytopenia (HP:0001913)2.39694195
64Premature loss of primary teeth (HP:0006323)2.38898980
65Abnormality of eosinophils (HP:0001879)2.37899897
66Episodic fever (HP:0001954)2.36908706
67Amyloidosis (HP:0011034)2.36249219
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.35113474
69Abnormality of T cell number (HP:0011839)2.33288495
70Abnormality of T cell physiology (HP:0011840)2.32566335
71IgA deficiency (HP:0002720)2.25879592
72IgG deficiency (HP:0004315)2.25029718
73Gastrointestinal inflammation (HP:0004386)2.24868755
74Gastrointestinal infarctions (HP:0005244)2.24013081
75Joint swelling (HP:0001386)2.23796690
76Increased serum ferritin (HP:0003281)2.23308543
77Abnormality of T cells (HP:0002843)2.21995692
78Increased IgE level (HP:0003212)2.21572581
79Encephalitis (HP:0002383)2.18507697
80Chronic diarrhea (HP:0002028)2.18121654
81Dysostosis multiplex (HP:0000943)2.16966986
82Abnormality of the pericardium (HP:0001697)2.16554500
83Cheilitis (HP:0100825)2.16005845
84Abnormality of the peritoneum (HP:0002585)2.13365783
85Hypochromic anemia (HP:0001931)2.13292620
86Gastrointestinal stroma tumor (HP:0100723)2.12920305
87Spontaneous hematomas (HP:0007420)2.11572384
88IgM deficiency (HP:0002850)2.10562413
89B lymphocytopenia (HP:0010976)2.09827528
90Abnormality of iron homeostasis (HP:0011031)2.09287990
91Increased cerebral lipofuscin (HP:0011813)2.08964968
92Epistaxis (HP:0000421)2.08827474
93Vertebral compression fractures (HP:0002953)2.07696918
94Loss of speech (HP:0002371)2.07686825
95Abnormality of the pleura (HP:0002103)2.07501300
96Panhypogammaglobulinemia (HP:0003139)2.06967165
97Porencephaly (HP:0002132)2.06740738
98Prolonged bleeding time (HP:0003010)2.06250412
99Alveolar cell carcinoma (HP:0006519)2.06029635
100Thyroiditis (HP:0100646)2.05440776
101Severe combined immunodeficiency (HP:0004430)2.04232094
102Sepsis (HP:0100806)2.03601442
103Inflammation of the large intestine (HP:0002037)2.03037504
104Colitis (HP:0002583)2.02772200
105Acute hepatic failure (HP:0006554)2.02028538
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.01914973
107Polyneuropathy (HP:0001271)2.00552580
108Skin rash (HP:0000988)2.00441921
109Gangrene (HP:0100758)1.99408797
110Anorexia (HP:0002039)1.98675399
111Vertigo (HP:0002321)1.97649525
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97416905
113Lymphopenia (HP:0001888)1.96265302
114Arthralgia (HP:0002829)1.96217503
115Purpura (HP:0000979)1.95585692
116Reduced antithrombin III activity (HP:0001976)1.95089793
117Skin ulcer (HP:0200042)1.93024115
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92447808
119Hematochezia (HP:0002573)1.92296457
120T lymphocytopenia (HP:0005403)1.90305595
121Chronic sinusitis (HP:0011109)1.89726539
122Glomerulopathy (HP:0100820)1.89296415
123Chromsome breakage (HP:0040012)1.86695121
124Keratitis (HP:0000491)1.86247539
125Albinism (HP:0001022)1.85974676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.37048155
2IRAK43.63174721
3IRAK33.27384670
4TXK3.03253794
5IKBKE3.02470495
6TBK12.99146015
7JAK32.88151681
8TYK22.78963655
9IKBKB2.60010302
10RIPK42.52817972
11KIT2.44636414
12MAP4K12.31322809
13BLK2.09281824
14GRK61.99176954
15PIM21.98921679
16JAK11.98434992
17TEC1.82894316
18MAP3K131.81438946
19EPHA31.75916627
20CHUK1.75546480
21PBK1.74390895
22BMPR21.72915528
23NLK1.66625731
24FGR1.62119004
25EIF2AK21.59146762
26BTK1.57711834
27BMPR1B1.49819794
28SYK1.46272098
29NME21.40584357
30SIK31.38266590
31ZAP701.36740375
32PRPF4B1.30112183
33TESK21.27172050
34EPHB11.25267414
35FGFR41.24084183
36ERN11.20682402
37HCK1.20681429
38IRAK11.19646057
39MAP3K111.17398673
40FGFR31.15893829
41PIM11.12966603
42MATK1.12711221
43MST41.09901028
44LYN1.08899699
45TAOK31.07679436
46YES11.05503581
47CSF1R1.05038531
48MAP3K11.04446415
49NEK91.03057502
50CSK1.01468557
51LCK1.00101967
52TGFBR20.99242959
53TAOK10.95569151
54ADRBK20.93230059
55ERBB30.92789115
56ZAK0.91474549
57TNIK0.91308676
58TGFBR10.88457918
59TRPM70.87817555
60MUSK0.87522989
61FLT30.86000233
62PTK2B0.79492921
63RPS6KA40.77601297
64NUAK10.77539864
65JAK20.73841603
66PIK3CG0.72676815
67TIE10.72470465
68KDR0.70302988
69PDK10.69764209
70LRRK20.67931759
71ITK0.67311281
72CDC42BPA0.65068430
73MAP2K30.64232168
74CAMKK20.64033850
75FES0.62393182
76PRKCD0.62101122
77MAP3K30.61969792
78MAP2K60.60840431
79FYN0.59059225
80MAP3K60.57683271
81MST1R0.55519798
82MOS0.54778482
83MAP3K20.53831690
84PDPK10.52723030
85RIPK10.52488259
86STK40.51938072
87ABL10.51886900
88PLK40.51413978
89CLK10.50438236
90KSR20.49948833
91GRK70.46418672
92TAOK20.46375989
93BMX0.44656098
94FRK0.44371929
95PRKCQ0.43751509
96MAPKAPK20.43492897
97GRK10.42356518
98MARK30.42296510
99MAP3K50.41378083
100MAPK110.39720203
101PRKG20.39119160
102PTK60.37865685
103MAPK70.37620805
104ACVR1B0.37605891
105RPS6KA50.36931545
106PRKD20.36715629
107MARK20.34671447
108CDK190.33644779
109IRAK20.33547674
110STK160.33474962
111PDGFRB0.32658601
112BRD40.32490655
113EGFR0.32478093
114MKNK10.31888971
115CDK80.31415451
116INSRR0.30449749
117GRK50.29489231
118ABL20.29186927
119TLK10.28333696
120ADRBK10.26949699
121TNK20.26472456
122STK100.26411610
123MAPK120.26047073
124IGF1R0.25607249
125INSR0.25421173
126RPS6KA60.24547995
127BCR0.23598694
128SGK30.22689036
129MAP3K120.20379838
130MAPK30.20075644
131ATR0.19567130
132MKNK20.19427475
133MAPK40.17715167
134HIPK20.17583490

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.38538427
2Allograft rejection_Homo sapiens_hsa053303.15537292
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07318197
4Leishmaniasis_Homo sapiens_hsa051403.04492238
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.92590321
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73873739
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.69348287
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61113712
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.55406228
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53781433
11Measles_Homo sapiens_hsa051622.37558539
12Legionellosis_Homo sapiens_hsa051342.33521808
13Malaria_Homo sapiens_hsa051442.23654896
14Asthma_Homo sapiens_hsa053102.16015363
15Pertussis_Homo sapiens_hsa051332.13698588
16Rheumatoid arthritis_Homo sapiens_hsa053232.08431659
17Staphylococcus aureus infection_Homo sapiens_hsa051502.05907604
18Osteoclast differentiation_Homo sapiens_hsa043802.04092650
19TNF signaling pathway_Homo sapiens_hsa046682.03573765
20African trypanosomiasis_Homo sapiens_hsa051431.96730367
21Type I diabetes mellitus_Homo sapiens_hsa049401.94432866
22Influenza A_Homo sapiens_hsa051641.94372214
23Herpes simplex infection_Homo sapiens_hsa051681.83151930
24Primary immunodeficiency_Homo sapiens_hsa053401.83061316
25Autoimmune thyroid disease_Homo sapiens_hsa053201.81966973
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78429699
27Hematopoietic cell lineage_Homo sapiens_hsa046401.76353096
28Tuberculosis_Homo sapiens_hsa051521.71863764
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.55412040
30Toxoplasmosis_Homo sapiens_hsa051451.52951989
31Salmonella infection_Homo sapiens_hsa051321.41416472
32B cell receptor signaling pathway_Homo sapiens_hsa046621.38357849
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35472257
34Apoptosis_Homo sapiens_hsa042101.34686820
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34462341
36Antigen processing and presentation_Homo sapiens_hsa046121.30081490
37Chemokine signaling pathway_Homo sapiens_hsa040621.25354294
38Hepatitis B_Homo sapiens_hsa051611.13180201
39Hepatitis C_Homo sapiens_hsa051601.11159625
40Phagosome_Homo sapiens_hsa041451.09902927
41Other glycan degradation_Homo sapiens_hsa005111.09452972
42Shigellosis_Homo sapiens_hsa051311.06026899
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04322654
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96474863
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96210055
46Viral myocarditis_Homo sapiens_hsa054160.94714937
47Lysosome_Homo sapiens_hsa041420.90086505
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.87171336
49T cell receptor signaling pathway_Homo sapiens_hsa046600.85933178
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82447418
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80050387
52Acute myeloid leukemia_Homo sapiens_hsa052210.75107429
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70963737
54Amoebiasis_Homo sapiens_hsa051460.68288325
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66293755
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.65551862
57Prolactin signaling pathway_Homo sapiens_hsa049170.64556789
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63631140
59Non-small cell lung cancer_Homo sapiens_hsa052230.60185376
60VEGF signaling pathway_Homo sapiens_hsa043700.59764237
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58603518
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57401758
63Small cell lung cancer_Homo sapiens_hsa052220.55573990
64Epstein-Barr virus infection_Homo sapiens_hsa051690.55545310
65Caffeine metabolism_Homo sapiens_hsa002320.52036950
66Endocytosis_Homo sapiens_hsa041440.50855105
67Chronic myeloid leukemia_Homo sapiens_hsa052200.47918869
68Platelet activation_Homo sapiens_hsa046110.47652894
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45621775
70p53 signaling pathway_Homo sapiens_hsa041150.44731371
71HTLV-I infection_Homo sapiens_hsa051660.42772808
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38491958
73Pancreatic cancer_Homo sapiens_hsa052120.38299928
74Insulin resistance_Homo sapiens_hsa049310.35332094
75Dorso-ventral axis formation_Homo sapiens_hsa043200.35075726
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34112330
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33101495
78Systemic lupus erythematosus_Homo sapiens_hsa053220.32882376
79Arachidonic acid metabolism_Homo sapiens_hsa005900.32600816
80Sphingolipid metabolism_Homo sapiens_hsa006000.32270987
81Renal cell carcinoma_Homo sapiens_hsa052110.31701250
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31614724
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.31565673
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.30402502
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29948869
86Prion diseases_Homo sapiens_hsa050200.29414375
87Viral carcinogenesis_Homo sapiens_hsa052030.28677309
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.28502846
89HIF-1 signaling pathway_Homo sapiens_hsa040660.28274833
90FoxO signaling pathway_Homo sapiens_hsa040680.27639904
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27403674
92Non-homologous end-joining_Homo sapiens_hsa034500.26516215
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26329662
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25623735
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24453584
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23193041
97ABC transporters_Homo sapiens_hsa020100.22363660
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21834304
99Bladder cancer_Homo sapiens_hsa052190.21267923
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20976288
101Base excision repair_Homo sapiens_hsa034100.20691817
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.18940790
103Notch signaling pathway_Homo sapiens_hsa043300.18259498
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.17818114
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17792781
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.17316311
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16931316
108GnRH signaling pathway_Homo sapiens_hsa049120.16798110
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15224200
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15059782
111Renin-angiotensin system_Homo sapiens_hsa046140.14714214
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14429339
113Complement and coagulation cascades_Homo sapiens_hsa046100.13446447
114Mineral absorption_Homo sapiens_hsa049780.12218916
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11838953
116Proteasome_Homo sapiens_hsa030500.11726720
117Vitamin digestion and absorption_Homo sapiens_hsa049770.11654795
118Regulation of autophagy_Homo sapiens_hsa041400.10996263
119MAPK signaling pathway_Homo sapiens_hsa040100.10907363
120MicroRNAs in cancer_Homo sapiens_hsa052060.10798221

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