CASP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact4.91302153
2modulation by symbiont of host immune response (GO:0052553)4.91302153
3positive regulation by symbiont of host defense response (GO:0052509)4.91302153
4modulation by symbiont of host defense response (GO:0052031)4.91302153
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91302153
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91302153
7negative regulation of interleukin-12 production (GO:0032695)4.81158943
8positive regulation of gamma-delta T cell activation (GO:0046645)4.76577160
9macrophage activation involved in immune response (GO:0002281)4.74022349
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71929749
11negative regulation of cell killing (GO:0031342)4.71929749
12response to peptidoglycan (GO:0032494)4.53384657
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39078758
14cellular response to type I interferon (GO:0071357)4.36753509
15type I interferon signaling pathway (GO:0060337)4.36753509
16response to type I interferon (GO:0034340)4.32156961
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.31370277
18detection of molecule of bacterial origin (GO:0032490)4.30450907
19neutrophil activation involved in immune response (GO:0002283)4.26355492
20immunoglobulin mediated immune response (GO:0016064)4.24577027
21regulation of interferon-beta biosynthetic process (GO:0045357)4.19641421
22antigen processing and presentation of endogenous antigen (GO:0019883)4.07241630
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.04451972
24detection of other organism (GO:0098543)4.02993314
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02771690
26regulation of interferon-alpha production (GO:0032647)3.83967456
27interferon-gamma-mediated signaling pathway (GO:0060333)3.76739588
28detection of external biotic stimulus (GO:0098581)3.74729416
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.73038428
30regulation of T-helper 1 cell differentiation (GO:0045625)3.67944115
31detection of bacterium (GO:0016045)3.64342821
32microglial cell activation (GO:0001774)3.63382294
33T-helper 1 type immune response (GO:0042088)3.58791445
34positive regulation of interferon-alpha production (GO:0032727)3.58148326
35defense response to protozoan (GO:0042832)3.54086399
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54085632
37regulation of vitamin D biosynthetic process (GO:0060556)3.52035210
38regulation of vitamin metabolic process (GO:0030656)3.49994363
39macrophage activation (GO:0042116)3.45311708
40regulation of gamma-delta T cell activation (GO:0046643)3.42265705
41positive regulation of type 2 immune response (GO:0002830)3.37835131
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35690255
43response to host immune response (GO:0052572)3.35690255
44germinal center formation (GO:0002467)3.35542987
45detection of biotic stimulus (GO:0009595)3.35252319
46neutrophil activation (GO:0042119)3.33861337
47granulocyte activation (GO:0036230)3.33374767
48B cell mediated immunity (GO:0019724)3.28451487
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24849056
50response to protozoan (GO:0001562)3.21336334
51leukocyte aggregation (GO:0070486)3.20544372
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.19829217
53positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17648229
54regulation of T-helper 2 cell differentiation (GO:0045628)3.14044884
55regulation of interleukin-8 biosynthetic process (GO:0045414)3.13201936
56myeloid cell activation involved in immune response (GO:0002275)3.12939653
57regulation of antigen processing and presentation (GO:0002577)3.10832597
58regulation of cytokine secretion involved in immune response (GO:0002739)3.09234663
59negative regulation of cytokine production involved in immune response (GO:0002719)3.08829508
60interferon-gamma secretion (GO:0072643)3.08784871
61production of molecular mediator involved in inflammatory response (GO:0002532)3.08630980
62positive regulation of antigen processing and presentation (GO:0002579)3.05926353
63respiratory burst (GO:0045730)3.02966421
64response to host (GO:0075136)3.02936365
65response to host defenses (GO:0052200)3.02936365
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02936365
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.02514858
68regulation of B cell receptor signaling pathway (GO:0050855)2.99587652
69negative regulation of T cell mediated immunity (GO:0002710)2.99048851
70cellular response to interferon-gamma (GO:0071346)2.98699899
71NIK/NF-kappaB signaling (GO:0038061)2.98594833
72regulation of T cell tolerance induction (GO:0002664)2.97390851
73negative regulation of lymphocyte mediated immunity (GO:0002707)2.97080880
74regulation of podosome assembly (GO:0071801)2.91478284
75positive regulation of interferon-beta production (GO:0032728)2.90965618
76cellular extravasation (GO:0045123)2.90330213
77regulation of cellular extravasation (GO:0002691)2.90325975
78positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89698390
79response to interferon-alpha (GO:0035455)2.89303804
80regulation of type 2 immune response (GO:0002828)2.88602701
81regulation of interleukin-12 production (GO:0032655)2.87688282
82dendritic cell chemotaxis (GO:0002407)2.87152674
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87152022
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.85826635
85regulation of tolerance induction (GO:0002643)2.85449095
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.85197712
87response to interferon-gamma (GO:0034341)2.84450754
88regulation of toll-like receptor signaling pathway (GO:0034121)2.83831914
89myeloid dendritic cell differentiation (GO:0043011)2.79632593
90response to muramyl dipeptide (GO:0032495)2.79480640
91negative regulation of viral genome replication (GO:0045071)2.78177214
92regulation of regulatory T cell differentiation (GO:0045589)2.74734737
93neutrophil mediated immunity (GO:0002446)2.74060438
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.73338727
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.72935010
96regulation of interleukin-1 beta secretion (GO:0050706)2.72129670
97positive regulation of chemokine biosynthetic process (GO:0045080)2.71748325
98negative regulation of leukocyte mediated immunity (GO:0002704)2.69945719
99positive regulation of acute inflammatory response (GO:0002675)2.67799863
100regulation of mast cell degranulation (GO:0043304)2.67434011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.49856066
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.94797160
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.81251614
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.67883241
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54909635
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.51246399
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28950479
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.24895209
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24351784
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12620774
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01702973
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90830014
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90265928
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66258221
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.55312589
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40847482
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37407929
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31517457
19RUNX_20019798_ChIP-Seq_JUKART_Human2.08877787
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.06960286
21SPI1_23547873_ChIP-Seq_NB4_Human2.05300667
22SPI1_23127762_ChIP-Seq_K562_Human2.03108451
23VDR_24763502_ChIP-Seq_THP-1_Human2.01967575
24VDR_24787735_ChIP-Seq_THP-1_Human1.94854267
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93720135
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85299551
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83778586
28GATA1_22025678_ChIP-Seq_K562_Human1.82165268
29MYB_26560356_Chip-Seq_TH2_Human1.75062994
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74230518
31SCL_19346495_ChIP-Seq_HPC-7_Human1.68713424
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68508376
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65592715
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63559928
35VDR_21846776_ChIP-Seq_THP-1_Human1.63119584
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61253545
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59370008
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.57939889
39MAF_26560356_Chip-Seq_TH1_Human1.56624543
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54500240
41MYB_26560356_Chip-Seq_TH1_Human1.45272658
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43854801
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36318388
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34592509
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33158900
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.28834601
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28261889
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27650323
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25155624
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25142944
51UTX_26944678_Chip-Seq_JUKART_Human1.24729725
52GATA3_27048872_Chip-Seq_THYMUS_Human1.23828130
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23692908
54PU_27001747_Chip-Seq_BMDM_Mouse1.23657376
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20697311
56TCF7_22412390_ChIP-Seq_EML_Mouse1.20275184
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.19764802
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19106971
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16560982
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13703359
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13257938
62GATA1_19941826_ChIP-Seq_K562_Human1.13218561
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12523238
64* GATA3_26560356_Chip-Seq_TH2_Human1.12140705
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11599920
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07110863
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05851543
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04374495
69EGR1_19032775_ChIP-ChIP_M12_Human1.01325969
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99686348
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99417156
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99381521
73GATA2_19941826_ChIP-Seq_K562_Human0.97629010
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97100899
75LXR_22158963_ChIP-Seq_LIVER_Mouse0.96539555
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96284999
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95503202
78KDM2B_26808549_Chip-Seq_DND41_Human0.95438610
79MAF_26560356_Chip-Seq_TH2_Human0.94780033
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94412044
81SOX2_20726797_ChIP-Seq_SW620_Human0.94135315
82TP63_17297297_ChIP-ChIP_HaCaT_Human0.90874491
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.90788402
84PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90535587
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88901839
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.88765245
87CDX2_20551321_ChIP-Seq_CACO-2_Human0.88198454
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87928851
89LXR_22292898_ChIP-Seq_THP-1_Human0.87159605
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.86517530
91STAT1_20625510_ChIP-Seq_HELA_Human0.84740118
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84167301
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81486032
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.80975265
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79576518
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78469646
97BCL6_27268052_Chip-Seq_Bcells_Human0.76085223
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74271885
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73851035
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73473126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.21853366
2MP0003303_peritoneal_inflammation5.10170429
3MP0003436_decreased_susceptibility_to3.61649888
4MP0001835_abnormal_antigen_presentation3.58426216
5MP0009785_altered_susceptibility_to3.43932897
6MP0006082_CNS_inflammation3.10171598
7MP0002148_abnormal_hypersensitivity_rea2.91601395
8MP0005671_abnormal_response_to2.78943109
9MP0005025_abnormal_response_to2.76959553
10MP0005387_immune_system_phenotype2.73798518
11MP0001790_abnormal_immune_system2.73798518
12MP0005000_abnormal_immune_tolerance2.72821601
13MP0002419_abnormal_innate_immunity2.66745794
14MP0010155_abnormal_intestine_physiology2.54362093
15MP0001800_abnormal_humoral_immune2.50316526
16MP0003300_gastrointestinal_ulcer2.45761072
17MP0002723_abnormal_immune_serum2.32455911
18MP0002452_abnormal_antigen_presenting2.26299659
19MP0001533_abnormal_skeleton_physiology2.21020718
20MP0009764_decreased_sensitivity_to2.16148466
21MP0000685_abnormal_immune_system2.12626567
22MP0004510_myositis2.08573537
23MP0005451_abnormal_body_composition2.01698458
24MP0001819_abnormal_immune_cell2.00769816
25MP0004947_skin_inflammation2.00144281
26MP0002420_abnormal_adaptive_immunity1.99417315
27MP0001845_abnormal_inflammatory_respons1.93311605
28MP0003075_altered_response_to1.87209542
29MP0008004_abnormal_stomach_pH1.72667308
30MP0003183_abnormal_peptide_metabolism1.69295026
31MP0009278_abnormal_bone_marrow1.67233084
32MP0002139_abnormal_hepatobiliary_system1.65696113
33MP0005058_abnormal_lysosome_morphology1.64933739
34MP0005166_decreased_susceptibility_to1.63513815
35MP0008469_abnormal_protein_level1.62476399
36MP0003191_abnormal_cellular_cholesterol1.57312329
37MP0003866_abnormal_defecation1.55782386
38MP0008260_abnormal_autophagy1.55592646
39MP0002405_respiratory_system_inflammati1.55369522
40MP0005464_abnormal_platelet_physiology1.50447940
41MP0000716_abnormal_immune_system1.45236455
42MP0005310_abnormal_salivary_gland1.42528029
43MP0000343_altered_response_to1.36021295
44MP0009333_abnormal_splenocyte_physiolog1.35070210
45MP0005397_hematopoietic_system_phenotyp1.34995716
46MP0001545_abnormal_hematopoietic_system1.34995716
47MP0003448_altered_tumor_morphology1.34899224
48MP0000858_altered_metastatic_potential1.34174113
49MP0009840_abnormal_foam_cell1.32876407
50MP0002398_abnormal_bone_marrow1.29638662
51MP0003172_abnormal_lysosome_physiology1.28590829
52MP0002998_abnormal_bone_remodeling1.28315949
53MP0001663_abnormal_digestive_system1.27935112
54MP0000465_gastrointestinal_hemorrhage1.27459704
55MP0005164_abnormal_response_to1.23079724
56MP0003806_abnormal_nucleotide_metabolis1.22319941
57MP0003763_abnormal_thymus_physiology1.20765266
58MP0000604_amyloidosis1.20343989
59MP0002332_abnormal_exercise_endurance1.16409644
60MP0002277_abnormal_respiratory_mucosa1.14127126
61MP0003690_abnormal_glial_cell1.13380796
62MP0001853_heart_inflammation1.11162197
63MP0002429_abnormal_blood_cell1.09710019
64MP0004883_abnormal_blood_vessel1.05978023
65MP0002722_abnormal_immune_system1.05344462
66MP0005360_urolithiasis1.04647467
67MP0006054_spinal_hemorrhage1.03930850
68MP0000689_abnormal_spleen_morphology1.03507569
69MP0003453_abnormal_keratinocyte_physiol0.99496074
70MP0005167_abnormal_blood-brain_barrier0.98765827
71MP0010352_gastrointestinal_tract_polyps0.97310668
72MP0001873_stomach_inflammation0.95642409
73MP0003828_pulmonary_edema0.95026580
74MP0009763_increased_sensitivity_to0.94988790
75MP0003656_abnormal_erythrocyte_physiolo0.92491310
76MP0002138_abnormal_hepatobiliary_system0.89928755
77MP0004858_abnormal_nervous_system0.89450018
78MP0009765_abnormal_xenobiotic_induced0.85405753
79MP0005390_skeleton_phenotype0.84042603
80MP0000490_abnormal_crypts_of0.83677521
81MP0002006_tumorigenesis0.83513147
82MP0005381_digestive/alimentary_phenotyp0.83372097
83MP0002166_altered_tumor_susceptibility0.78566339
84MP0003329_amyloid_beta_deposits0.76892315
85MP0002132_abnormal_respiratory_system0.75945143
86MP0001501_abnormal_sleep_pattern0.75277470
87MP0005085_abnormal_gallbladder_physiolo0.75238614
88MP0010234_abnormal_vibrissa_follicle0.74825186
89MP0000249_abnormal_blood_vessel0.74280633
90MP0001851_eye_inflammation0.70990371
91MP0005535_abnormal_body_temperature0.70144730
92MP0002254_reproductive_system_inflammat0.69787425
93MP0003091_abnormal_cell_migration0.69618518
94MP0008874_decreased_physiological_sensi0.68847940
95MP0003045_fibrosis0.67994851
96MP0004264_abnormal_extraembryonic_tissu0.67792401
97MP0005319_abnormal_enzyme/_coenzyme0.65280400
98MP0003195_calcinosis0.64149292
99MP0000609_abnormal_liver_physiology0.60973012
100MP0000703_abnormal_thymus_morphology0.60458787

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)6.04903546
2Eczematoid dermatitis (HP:0000976)5.89007563
3Retrobulbar optic neuritis (HP:0100654)5.87845651
4Optic neuritis (HP:0100653)5.87845651
5Myositis (HP:0100614)5.61053979
6Recurrent bacterial skin infections (HP:0005406)5.36709512
7Recurrent abscess formation (HP:0002722)5.11334183
8Abnormality of macrophages (HP:0004311)5.06005492
9Stomatitis (HP:0010280)4.59274506
10Keratoconjunctivitis sicca (HP:0001097)4.25342344
11Elevated erythrocyte sedimentation rate (HP:0003565)4.15185808
12Keratoconjunctivitis (HP:0001096)3.90508366
13Recurrent gram-negative bacterial infections (HP:0005420)3.89828505
14Mediastinal lymphadenopathy (HP:0100721)3.89223049
15Gastrointestinal infarctions (HP:0005244)3.82318114
16Systemic lupus erythematosus (HP:0002725)3.74534782
17Vasculitis (HP:0002633)3.64098141
18Recurrent fungal infections (HP:0002841)3.40286264
19Gingivitis (HP:0000230)3.37008298
20Encephalitis (HP:0002383)3.33355745
21Abnormality of liposaccharide metabolism (HP:0010968)3.31140006
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.31140006
23Abnormality of glycolipid metabolism (HP:0010969)3.31140006
24Recurrent skin infections (HP:0001581)3.30793081
25Hemoptysis (HP:0002105)3.28207365
26Pulmonary infiltrates (HP:0002113)3.25108449
27Obstructive lung disease (HP:0006536)3.22443583
28Chronic obstructive pulmonary disease (HP:0006510)3.22443583
29Meningitis (HP:0001287)3.20544202
30Increased IgM level (HP:0003496)3.16368337
31Malnutrition (HP:0004395)3.14557019
32Abnormality of T cell number (HP:0011839)3.12107062
33Autoimmune thrombocytopenia (HP:0001973)3.06381492
34T lymphocytopenia (HP:0005403)3.05142442
35Arterial thrombosis (HP:0004420)3.02372401
36Amyloidosis (HP:0011034)3.00934677
37Gangrene (HP:0100758)2.98530472
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.94989069
39Urticaria (HP:0001025)2.92041358
40Spontaneous hematomas (HP:0007420)2.89516955
41Loss of speech (HP:0002371)2.87728422
42Peritonitis (HP:0002586)2.82064399
43Leukocytosis (HP:0001974)2.76752449
44Anorexia (HP:0002039)2.73765546
45Disinhibition (HP:0000734)2.70731042
46Recurrent viral infections (HP:0004429)2.66355354
47Increased IgE level (HP:0003212)2.64644272
48Pulmonary embolism (HP:0002204)2.58025513
49Episodic fever (HP:0001954)2.57549551
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54449779
51Chest pain (HP:0100749)2.54412498
52Abnormality of the pleura (HP:0002103)2.53356530
53Recurrent cutaneous fungal infections (HP:0011370)2.53200638
54Chronic mucocutaneous candidiasis (HP:0002728)2.53200638
55Autoimmune hemolytic anemia (HP:0001890)2.46631049
56Gingival bleeding (HP:0000225)2.45319148
57Vacuolated lymphocytes (HP:0001922)2.42212704
58Increased cerebral lipofuscin (HP:0011813)2.41106407
59Hypergammaglobulinemia (HP:0010702)2.38491075
60Chronic diarrhea (HP:0002028)2.35115936
61Petechiae (HP:0000967)2.33343397
62Interstitial pulmonary disease (HP:0006530)2.31084148
63Dysostosis multiplex (HP:0000943)2.28925505
64Cellulitis (HP:0100658)2.28248493
65Hematochezia (HP:0002573)2.27441272
66Chronic otitis media (HP:0000389)2.24948754
67Glomerulonephritis (HP:0000099)2.21764615
68Joint swelling (HP:0001386)2.21627546
69Inflammation of the large intestine (HP:0002037)2.21201499
70Polyneuropathy (HP:0001271)2.20873478
71Acne (HP:0001061)2.18807632
72Vertigo (HP:0002321)2.17644185
73Abnormality of T cells (HP:0002843)2.15725828
74Glomerulopathy (HP:0100820)2.15437797
75Colitis (HP:0002583)2.14790559
76Eosinophilia (HP:0001880)2.10841309
77Abnormality of the endocardium (HP:0004306)2.10839307
78Abnormality of the pericardium (HP:0001697)2.10125474
79Granulocytopenia (HP:0001913)2.08695507
80Gastrointestinal inflammation (HP:0004386)2.06270539
81Purpura (HP:0000979)2.05978796
82Increased serum ferritin (HP:0003281)2.05902480
83Premature loss of primary teeth (HP:0006323)2.05802219
84Recurrent bronchitis (HP:0002837)2.03833334
85Abnormality of the peritoneum (HP:0002585)2.03198034
86Osteomyelitis (HP:0002754)2.03044846
87Abnormality of B cell number (HP:0010975)2.01827978
88Epistaxis (HP:0000421)2.00969501
89Keratitis (HP:0000491)1.97264007
90Prolonged bleeding time (HP:0003010)1.97235170
91Abnormality of the nasal mucosa (HP:0000433)1.96602852
92Arthralgia (HP:0002829)1.90617043
93Abnormality of iron homeostasis (HP:0011031)1.90078422
94Nasal polyposis (HP:0100582)1.87445233
95Pustule (HP:0200039)1.86762574
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86048441
97Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86026158
98Segmental peripheral demyelination/remyelination (HP:0003481)1.85671300
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.85389361
100Sepsis (HP:0100806)1.85066531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.08329913
2IRAK43.19454664
3TYK23.12632443
4BLK2.93695600
5ERN12.79076092
6MAP4K12.78122474
7IRAK32.76749031
8MAP3K142.70991537
9CSK2.59925577
10IKBKE2.40657203
11RIPK12.37389012
12MATK2.23998679
13TXK2.20227512
14TBK12.16474286
15JAK32.09457321
16MAP2K32.08765393
17FGR2.05222625
18ACVR1B1.98313004
19TAOK11.91970604
20PRPF4B1.86463694
21BMPR21.82534533
22GRK71.82107170
23IRAK11.79572715
24ZAP701.79039626
25EPHB11.76060220
26MAP3K111.63212383
27TAOK21.62380482
28JAK11.60960719
29MAP3K31.56341181
30IKBKB1.52634008
31JAK21.51695355
32FES1.44851606
33MAP3K11.43497743
34SYK1.39041461
35GRK61.38054928
36LYN1.37500893
37IRAK21.37374534
38EPHA31.28505455
39BTK1.27268740
40HCK1.21644385
41CDC42BPA1.17305451
42DDR21.17303315
43FGFR41.12748611
44TGFBR21.05516577
45MAP3K131.03277937
46TAOK30.99888485
47CSF1R0.99466280
48FGFR30.95334350
49LCK0.94732973
50TNK20.91223589
51KIT0.91055952
52MAP3K50.89429495
53KSR20.86730503
54YES10.82792756
55CHUK0.74784264
56MOS0.71482298
57MAP2K60.70500825
58SIK30.70110584
59TESK20.69536665
60PTK60.68329378
61MAP3K60.67585522
62PRKG20.66748252
63STK240.65918669
64MAP3K20.65053891
65PIM10.64720372
66PDK10.63713882
67ITK0.63087793
68MARK30.59826582
69PDPK10.57598753
70ADRBK20.57288961
71STK100.56770728
72NLK0.55287957
73TEC0.54489987
74FYN0.54380034
75DYRK1B0.53536193
76NME20.49231728
77DYRK30.48713972
78PIM20.48155481
79HIPK20.47631554
80MARK20.40302816
81DAPK20.39302080
82MAPK70.38116166
83LRRK20.36977489
84BMX0.35842597
85PIK3CA0.34371353
86MAPKAPK20.33595967
87CLK10.32387241
88MST1R0.32031705
89PRKCD0.28522070
90KSR10.27728661
91CDK60.26261985
92EGFR0.25837413
93RPS6KC10.25682557
94RPS6KL10.25682557
95SGK30.25646507
96PIK3CG0.25046880
97PRKCQ0.24798673
98PTK2B0.24736102
99PRKCZ0.23978649
100PRKAA20.23420768

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.06557199
2Staphylococcus aureus infection_Homo sapiens_hsa051502.86595602
3Osteoclast differentiation_Homo sapiens_hsa043802.74053063
4Allograft rejection_Homo sapiens_hsa053302.65147569
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60299271
6Graft-versus-host disease_Homo sapiens_hsa053322.52546191
7Autoimmune thyroid disease_Homo sapiens_hsa053202.22686311
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.21753853
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21498782
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21283294
11Asthma_Homo sapiens_hsa053102.18361302
12* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13119592
13Tuberculosis_Homo sapiens_hsa051522.12655074
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.04294984
15Malaria_Homo sapiens_hsa051441.98166171
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96942483
17Legionellosis_Homo sapiens_hsa051341.95334472
18Type I diabetes mellitus_Homo sapiens_hsa049401.89477340
19Pertussis_Homo sapiens_hsa051331.89196402
20TNF signaling pathway_Homo sapiens_hsa046681.88221378
21Influenza A_Homo sapiens_hsa051641.80666800
22African trypanosomiasis_Homo sapiens_hsa051431.80391010
23Rheumatoid arthritis_Homo sapiens_hsa053231.73923127
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.67054596
25Toxoplasmosis_Homo sapiens_hsa051451.63008347
26Measles_Homo sapiens_hsa051621.61768368
27B cell receptor signaling pathway_Homo sapiens_hsa046621.51844525
28Hematopoietic cell lineage_Homo sapiens_hsa046401.48924111
29Salmonella infection_Homo sapiens_hsa051321.45676298
30Other glycan degradation_Homo sapiens_hsa005111.44898612
31Antigen processing and presentation_Homo sapiens_hsa046121.44310172
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41314574
33Chemokine signaling pathway_Homo sapiens_hsa040621.41064818
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39090788
35Hepatitis C_Homo sapiens_hsa051601.38395493
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33893726
37Herpes simplex infection_Homo sapiens_hsa051681.32796429
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.27846933
39Primary immunodeficiency_Homo sapiens_hsa053401.23413022
40Viral myocarditis_Homo sapiens_hsa054161.22634821
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21175641
42Phagosome_Homo sapiens_hsa041451.12697152
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08084067
44Hepatitis B_Homo sapiens_hsa051611.04745239
45T cell receptor signaling pathway_Homo sapiens_hsa046601.01453760
46Acute myeloid leukemia_Homo sapiens_hsa052210.99176390
47Lysosome_Homo sapiens_hsa041420.96681008
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.88201228
49Renin-angiotensin system_Homo sapiens_hsa046140.87036103
50Apoptosis_Homo sapiens_hsa042100.84990032
51Shigellosis_Homo sapiens_hsa051310.84939528
52Prolactin signaling pathway_Homo sapiens_hsa049170.84315303
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83284580
54Amoebiasis_Homo sapiens_hsa051460.81273939
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.76090190
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75416841
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72636894
58Sulfur metabolism_Homo sapiens_hsa009200.72357597
59Mineral absorption_Homo sapiens_hsa049780.71788168
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69714943
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69675126
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.65450140
63Galactose metabolism_Homo sapiens_hsa000520.59476387
64Fat digestion and absorption_Homo sapiens_hsa049750.56279501
65Vitamin digestion and absorption_Homo sapiens_hsa049770.55651355
66VEGF signaling pathway_Homo sapiens_hsa043700.53916877
67Prion diseases_Homo sapiens_hsa050200.53642406
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51790350
69Platelet activation_Homo sapiens_hsa046110.51406348
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.51086259
71Fructose and mannose metabolism_Homo sapiens_hsa000510.48742299
72PPAR signaling pathway_Homo sapiens_hsa033200.47368343
73Epstein-Barr virus infection_Homo sapiens_hsa051690.47269635
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47269091
75Type II diabetes mellitus_Homo sapiens_hsa049300.46472426
76Dorso-ventral axis formation_Homo sapiens_hsa043200.46218798
77Insulin resistance_Homo sapiens_hsa049310.45327836
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.44470225
79Pancreatic cancer_Homo sapiens_hsa052120.43603563
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43152430
81Complement and coagulation cascades_Homo sapiens_hsa046100.42119914
82HIF-1 signaling pathway_Homo sapiens_hsa040660.41543761
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41357138
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.38853989
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38314602
86Arachidonic acid metabolism_Homo sapiens_hsa005900.37274755
87Chronic myeloid leukemia_Homo sapiens_hsa052200.36767317
88FoxO signaling pathway_Homo sapiens_hsa040680.35895781
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35274275
90Bladder cancer_Homo sapiens_hsa052190.34853611
91Non-small cell lung cancer_Homo sapiens_hsa052230.33156924
92Endocytosis_Homo sapiens_hsa041440.32593522
93Starch and sucrose metabolism_Homo sapiens_hsa005000.32008009
94Sphingolipid metabolism_Homo sapiens_hsa006000.30580505
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30019673
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.29222474
97Viral carcinogenesis_Homo sapiens_hsa052030.28622740
98Notch signaling pathway_Homo sapiens_hsa043300.28398129
99Renal cell carcinoma_Homo sapiens_hsa052110.27506288
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26593362

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