CASP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.67036684
2ATP synthesis coupled proton transport (GO:0015986)5.00945061
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.00945061
4ribosomal small subunit assembly (GO:0000028)4.66724764
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.23316521
6protein neddylation (GO:0045116)4.20440031
7cullin deneddylation (GO:0010388)4.19320131
8chaperone-mediated protein transport (GO:0072321)4.15790604
9protein complex biogenesis (GO:0070271)4.03316350
10protein deneddylation (GO:0000338)4.02456880
11mitochondrial respiratory chain complex assembly (GO:0033108)3.90821561
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85220272
13respiratory chain complex IV assembly (GO:0008535)3.83462829
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.83437105
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.81544184
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76327492
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.76327492
18NADH dehydrogenase complex assembly (GO:0010257)3.76327492
19respiratory electron transport chain (GO:0022904)3.75338918
20electron transport chain (GO:0022900)3.72040194
21maturation of SSU-rRNA (GO:0030490)3.56757174
22viral transcription (GO:0019083)3.55264289
23cytochrome complex assembly (GO:0017004)3.53702294
24proteasome assembly (GO:0043248)3.47850477
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46491449
26ribosomal large subunit biogenesis (GO:0042273)3.44449619
27translational termination (GO:0006415)3.43596226
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35999690
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35999690
30purine nucleobase biosynthetic process (GO:0009113)3.35863694
31DNA deamination (GO:0045006)3.31071556
32ribosomal small subunit biogenesis (GO:0042274)3.22070687
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17519933
34water-soluble vitamin biosynthetic process (GO:0042364)3.14110170
35replication fork processing (GO:0031297)3.09272693
36cotranslational protein targeting to membrane (GO:0006613)3.07529257
37DNA double-strand break processing (GO:0000729)3.07049185
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05084798
39protein targeting to ER (GO:0045047)3.05077324
40oxidative phosphorylation (GO:0006119)3.04732931
41mannosylation (GO:0097502)3.04666232
42regulation of mitotic spindle checkpoint (GO:1903504)3.02534443
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02534443
44establishment of integrated proviral latency (GO:0075713)3.02448666
45histone exchange (GO:0043486)3.00870104
46maturation of 5.8S rRNA (GO:0000460)3.00722507
47translational elongation (GO:0006414)2.97418032
48formation of translation preinitiation complex (GO:0001731)2.96251699
49protein localization to endoplasmic reticulum (GO:0070972)2.91054957
50nucleobase biosynthetic process (GO:0046112)2.89079291
51base-excision repair, AP site formation (GO:0006285)2.87743735
52DNA catabolic process, exonucleolytic (GO:0000738)2.87008847
53regulation of metalloenzyme activity (GO:0048552)2.86872019
54deoxyribonucleotide catabolic process (GO:0009264)2.84748621
55establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83941298
56protein targeting to mitochondrion (GO:0006626)2.83522066
57deoxyribose phosphate catabolic process (GO:0046386)2.83286591
58tRNA processing (GO:0008033)2.78600456
59pyrimidine nucleotide catabolic process (GO:0006244)2.77758583
60rRNA modification (GO:0000154)2.76369970
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74362102
62protein K6-linked ubiquitination (GO:0085020)2.74215693
63DNA damage response, detection of DNA damage (GO:0042769)2.73919067
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73179869
65translational initiation (GO:0006413)2.73118106
66peptidyl-histidine modification (GO:0018202)2.72705449
67DNA ligation (GO:0006266)2.71688756
68ATP biosynthetic process (GO:0006754)2.71497869
69folic acid metabolic process (GO:0046655)2.70569349
70rRNA metabolic process (GO:0016072)2.69408621
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68008090
72viral life cycle (GO:0019058)2.67588554
73ubiquinone biosynthetic process (GO:0006744)2.66726496
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66705330
75mitochondrial RNA metabolic process (GO:0000959)2.66680857
76preassembly of GPI anchor in ER membrane (GO:0016254)2.65669623
77protein-cofactor linkage (GO:0018065)2.64174633
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63855050
79mitotic metaphase plate congression (GO:0007080)2.63262574
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60713358
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55009016
82translation (GO:0006412)2.53380751
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51931473
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51065783
85ribonucleoprotein complex biogenesis (GO:0022613)2.48772081
86cellular protein complex disassembly (GO:0043624)2.48542617
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46751369
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46751369
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46751369
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45333059
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45333059
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.43197193
93termination of RNA polymerase III transcription (GO:0006386)2.43197193
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42901862
95regulation of cellular amino acid metabolic process (GO:0006521)2.41141875
96negative regulation of ligase activity (GO:0051352)2.40251046
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40251046
98telomere maintenance via semi-conservative replication (GO:0032201)2.40141053
99cellular glucuronidation (GO:0052695)2.37189745
100DNA strand elongation involved in DNA replication (GO:0006271)2.36009088
101CENP-A containing nucleosome assembly (GO:0034080)2.35304023
102metaphase plate congression (GO:0051310)2.34936039
103regulation of mitochondrial translation (GO:0070129)2.34713037
104DNA replication checkpoint (GO:0000076)2.34316148
105termination of RNA polymerase I transcription (GO:0006363)2.34236825
106signal transduction involved in DNA damage checkpoint (GO:0072422)2.34067739
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34067739
108regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.33817905
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.32260819
110telomere maintenance via recombination (GO:0000722)2.31877549
111rRNA methylation (GO:0031167)2.29077328
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.28920099
113DNA strand elongation (GO:0022616)2.28765268
1147-methylguanosine mRNA capping (GO:0006370)2.26396629
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.24730542
116nucleotide-sugar biosynthetic process (GO:0009226)2.24011844
117positive regulation of ligase activity (GO:0051351)2.23500933
118transcription from RNA polymerase I promoter (GO:0006360)2.21801133
119glucuronate metabolic process (GO:0019585)2.21644624
120uronic acid metabolic process (GO:0006063)2.21644624
121pseudouridine synthesis (GO:0001522)2.20996853
122antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.19861098
123viral mRNA export from host cell nucleus (GO:0046784)2.19437367
1247-methylguanosine RNA capping (GO:0009452)2.18481366
125RNA capping (GO:0036260)2.18481366
126mitotic recombination (GO:0006312)2.16746232
127tryptophan metabolic process (GO:0006568)2.16253777
128chromatin remodeling at centromere (GO:0031055)2.16040417
129folic acid transport (GO:0015884)2.13475328
130transcription elongation from RNA polymerase I promoter (GO:0006362)2.12130121
131UDP-N-acetylglucosamine metabolic process (GO:0006047)2.11602889
132intestinal absorption (GO:0050892)2.10924239
133diterpenoid biosynthetic process (GO:0016102)2.10597013
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.10452328
135positive regulation of cell cycle arrest (GO:0071158)2.10355370
136glycine metabolic process (GO:0006544)2.09944346
137protein complex disassembly (GO:0043241)2.09867224
138response to nitrosative stress (GO:0051409)2.09824773
139indole-containing compound catabolic process (GO:0042436)2.09705591
140indolalkylamine catabolic process (GO:0046218)2.09705591
141tryptophan catabolic process (GO:0006569)2.09705591
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.08799209
143rRNA processing (GO:0006364)2.08738302
144signal peptide processing (GO:0006465)2.07289090
145regulation of cholesterol esterification (GO:0010872)2.06373527
146regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.06263890
147positive regulation of respiratory burst (GO:0060267)2.04806439
148transcription-coupled nucleotide-excision repair (GO:0006283)2.04674799
149cellular component biogenesis (GO:0044085)2.04051609
150telomere maintenance via telomere lengthening (GO:0010833)2.03571588
151positive regulation of keratinocyte differentiation (GO:0045618)2.01655240
152homocysteine metabolic process (GO:0050667)2.01615116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.58418169
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46343425
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.09612940
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.97042087
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84878273
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74601451
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70495370
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70182127
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69377564
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66039381
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63760813
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51936282
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50375732
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.37075541
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36792303
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34118544
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.32957481
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21468715
19* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21279343
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.12208821
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11604770
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06380565
23ZNF274_21170338_ChIP-Seq_K562_Hela2.03918501
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00928646
25* VDR_23849224_ChIP-Seq_CD4+_Human1.99137604
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.98743924
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97805053
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97014713
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.96761395
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94898796
31VDR_22108803_ChIP-Seq_LS180_Human1.92184755
32DCP1A_22483619_ChIP-Seq_HELA_Human1.89546785
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87858956
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87445333
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86037749
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85821465
37FOXP3_21729870_ChIP-Seq_TREG_Human1.85135438
38* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84250421
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83851276
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81221351
41AR_21909140_ChIP-Seq_LNCAP_Human1.77545045
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.76754577
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75846671
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75732887
45XRN2_22483619_ChIP-Seq_HELA_Human1.73699065
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70743650
47EWS_26573619_Chip-Seq_HEK293_Human1.70056253
48ELK1_19687146_ChIP-ChIP_HELA_Human1.69064006
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65633916
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65001509
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63270467
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61623154
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60612793
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59737108
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58213204
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57367592
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52183675
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.44038188
59* TTF2_22483619_ChIP-Seq_HELA_Human1.43512212
60IRF1_19129219_ChIP-ChIP_H3396_Human1.42982876
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42746771
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42707659
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.42022663
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.41719255
65GABP_19822575_ChIP-Seq_HepG2_Human1.39911895
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30652382
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30175380
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29856114
69SPI1_23547873_ChIP-Seq_NB4_Human1.27522617
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.26735867
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.25923509
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20686062
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20646411
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.20053949
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.19730701
76* E2F1_21310950_ChIP-Seq_MCF-7_Human1.18918446
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18773885
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.18250259
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17536207
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16705698
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16226661
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15213186
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13656915
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13230823
85FUS_26573619_Chip-Seq_HEK293_Human1.11903959
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.10788656
87TP53_22573176_ChIP-Seq_HFKS_Human1.10241639
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07094947
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.07094947
90AR_20517297_ChIP-Seq_VCAP_Human1.07087346
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05192565
92GATA1_22025678_ChIP-Seq_K562_Human1.05057384
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04512848
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04000583
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01462902
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.00431621
97IGF1R_20145208_ChIP-Seq_DFB_Human0.99412502
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99316342
99GATA4_25053715_ChIP-Seq_YYC3_Human0.98111243
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.97992687
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97816711
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96424699
103CIITA_25753668_ChIP-Seq_RAJI_Human0.95749041
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94471621
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93956178
106MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93548182
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93346871
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92520975
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92059229
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91795572
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91686483
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.91480559
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89990602
114KDM5A_27292631_Chip-Seq_BREAST_Human0.89791731
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87904365
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87862738
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87094629
118* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86489400
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.86415860
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86376998
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86077383
122MYC_18940864_ChIP-ChIP_HL60_Human0.85411321
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84949799
124SOX2_19829295_ChIP-Seq_ESCs_Human0.84552121
125NANOG_19829295_ChIP-Seq_ESCs_Human0.84552121
126HTT_18923047_ChIP-ChIP_STHdh_Human0.84414010
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81497192
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81243786
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80581310
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80485913
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78782659
132FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78277360
133NANOG_20526341_ChIP-Seq_ESCs_Human0.77635570
134ERG_20517297_ChIP-Seq_VCAP_Human0.76658440
135GATA3_21878914_ChIP-Seq_MCF-7_Human0.75308109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.18192137
2MP0006292_abnormal_olfactory_placode2.87619765
3MP0008877_abnormal_DNA_methylation2.87509414
4MP0003693_abnormal_embryo_hatching2.76412302
5MP0009697_abnormal_copulation2.55008062
6MP0002139_abnormal_hepatobiliary_system2.52179355
7MP0005085_abnormal_gallbladder_physiolo2.29986650
8MP0006036_abnormal_mitochondrial_physio2.13912498
9MP0003806_abnormal_nucleotide_metabolis2.11495457
10MP0002132_abnormal_respiratory_system1.97111911
11MP0005365_abnormal_bile_salt1.92079483
12MP0001835_abnormal_antigen_presentation1.87521998
13MP0008932_abnormal_embryonic_tissue1.87153128
14MP0003186_abnormal_redox_activity1.80242827
15MP0006072_abnormal_retinal_apoptosis1.77316230
16MP0006054_spinal_hemorrhage1.76383686
17MP0001293_anophthalmia1.74093094
18MP0008872_abnormal_physiological_respon1.74037704
19MP0002102_abnormal_ear_morphology1.73815821
20MP0009840_abnormal_foam_cell1.71555331
21MP0008875_abnormal_xenobiotic_pharmacok1.71422162
22MP0009379_abnormal_foot_pigmentation1.70814432
23MP0002396_abnormal_hematopoietic_system1.68093893
24MP0001666_abnormal_nutrient_absorption1.65092875
25MP0003195_calcinosis1.63191933
26MP0008789_abnormal_olfactory_epithelium1.63114405
27MP0008995_early_reproductive_senescence1.62160199
28MP0008007_abnormal_cellular_replicative1.58028560
29MP0005084_abnormal_gallbladder_morpholo1.57582760
30MP0010094_abnormal_chromosome_stability1.54256943
31MP0009785_altered_susceptibility_to1.51971249
32MP0004957_abnormal_blastocyst_morpholog1.51177303
33MP0002138_abnormal_hepatobiliary_system1.49526811
34MP0001986_abnormal_taste_sensitivity1.49498939
35MP0000490_abnormal_crypts_of1.49266415
36MP0003111_abnormal_nucleus_morphology1.48739723
37MP0001764_abnormal_homeostasis1.46146308
38MP0003718_maternal_effect1.43772953
39MP0009333_abnormal_splenocyte_physiolog1.42311717
40MP0006035_abnormal_mitochondrial_morpho1.41447579
41MP0005646_abnormal_pituitary_gland1.40373672
42MP0001542_abnormal_bone_strength1.40304778
43MP0004147_increased_porphyrin_level1.40058913
44MP0004019_abnormal_vitamin_homeostasis1.38348844
45MP0010155_abnormal_intestine_physiology1.37394304
46MP0003763_abnormal_thymus_physiology1.37373137
47MP0001873_stomach_inflammation1.36692022
48MP0005395_other_phenotype1.36496135
49MP0000566_synostosis1.36472960
50MP0003724_increased_susceptibility_to1.35717009
51MP0005408_hypopigmentation1.34331259
52MP0003136_yellow_coat_color1.33998185
53MP0008058_abnormal_DNA_repair1.33682483
54MP0003077_abnormal_cell_cycle1.32653420
55MP0003252_abnormal_bile_duct1.31715784
56MP0003011_delayed_dark_adaptation1.30307384
57MP0003787_abnormal_imprinting1.27809295
58MP0004782_abnormal_surfactant_physiolog1.27097105
59MP0010368_abnormal_lymphatic_system1.25419745
60MP0002876_abnormal_thyroid_physiology1.24327155
61MP0003786_premature_aging1.22834391
62MP0008004_abnormal_stomach_pH1.20771140
63MP0005410_abnormal_fertilization1.20215933
64MP0001853_heart_inflammation1.19999512
65MP0002160_abnormal_reproductive_system1.19679657
66MP0002736_abnormal_nociception_after1.17937458
67MP0009053_abnormal_anal_canal1.16730895
68MP0005332_abnormal_amino_acid1.15232784
69MP0010329_abnormal_lipoprotein_level1.12724014
70MP0005451_abnormal_body_composition1.11514021
71MP0001929_abnormal_gametogenesis1.10833971
72MP0005636_abnormal_mineral_homeostasis1.10396199
73MP0000685_abnormal_immune_system1.09194070
74MP0002148_abnormal_hypersensitivity_rea1.08408356
75MP0001879_abnormal_lymphatic_vessel1.07489051
76MP0000653_abnormal_sex_gland1.06399422
77MP0005551_abnormal_eye_electrophysiolog1.06189522
78MP0002166_altered_tumor_susceptibility1.05468977
79MP0005671_abnormal_response_to1.05116232
80MP0001529_abnormal_vocalization1.04507817
81MP0005025_abnormal_response_to1.04383502
82MP0003567_abnormal_fetal_cardiomyocyte1.04102215
83MP0003941_abnormal_skin_development1.04098725
84MP0002938_white_spotting1.03806918
85MP0001919_abnormal_reproductive_system1.03436442
86MP0002095_abnormal_skin_pigmentation1.03332823
87MP0002210_abnormal_sex_determination1.03214600
88MP0001485_abnormal_pinna_reflex1.03180136
89MP0009764_decreased_sensitivity_to1.01308569
90MP0003121_genomic_imprinting0.99068214
91MP0002452_abnormal_antigen_presenting0.98967128
92MP0002405_respiratory_system_inflammati0.98618106
93MP0001545_abnormal_hematopoietic_system0.98389166
94MP0005397_hematopoietic_system_phenotyp0.98389166
95MP0001145_abnormal_male_reproductive0.97985495
96MP0002234_abnormal_pharynx_morphology0.97615396
97MP0008775_abnormal_heart_ventricle0.97166775
98MP0008057_abnormal_DNA_replication0.96449860
99MP0005174_abnormal_tail_pigmentation0.96382524
100MP0000631_abnormal_neuroendocrine_gland0.95671654
101MP0001119_abnormal_female_reproductive0.94979698
102MP0005645_abnormal_hypothalamus_physiol0.94407368
103MP0008469_abnormal_protein_level0.94197670
104MP0000372_irregular_coat_pigmentation0.93573240
105MP0000465_gastrointestinal_hemorrhage0.93541304
106MP0005075_abnormal_melanosome_morpholog0.93355464
107MP0005319_abnormal_enzyme/_coenzyme0.93287630
108MP0002638_abnormal_pupillary_reflex0.93038088
109MP0005464_abnormal_platelet_physiology0.92537588
110MP0005253_abnormal_eye_physiology0.91948872
111MP0001800_abnormal_humoral_immune0.91211169
112MP0002419_abnormal_innate_immunity0.90353205
113MP0009643_abnormal_urine_homeostasis0.89610289
114MP0003123_paternal_imprinting0.88073024
115MP0002277_abnormal_respiratory_mucosa0.87568042
116MP0001845_abnormal_inflammatory_respons0.87094943
117MP0002254_reproductive_system_inflammat0.86497521
118MP0006082_CNS_inflammation0.86155078
119MP0001881_abnormal_mammary_gland0.85137734
120MP0002009_preneoplasia0.84867464
121MP0001819_abnormal_immune_cell0.84065111
122MP0000689_abnormal_spleen_morphology0.83774866
123MP0002420_abnormal_adaptive_immunity0.83402739
124MP0002098_abnormal_vibrissa_morphology0.83247006
125MP0000609_abnormal_liver_physiology0.83059234
126MP0000647_abnormal_sebaceous_gland0.82944705
127MP0000358_abnormal_cell_content/0.82561902
128MP0001790_abnormal_immune_system0.82293874
129MP0005387_immune_system_phenotype0.82293874
130MP0004133_heterotaxia0.81647803
131MP0005394_taste/olfaction_phenotype0.81582367
132MP0005499_abnormal_olfactory_system0.81582367
133MP0000516_abnormal_urinary_system0.81510707
134MP0005367_renal/urinary_system_phenotyp0.81510707
135MP0002722_abnormal_immune_system0.81420479
136MP0002019_abnormal_tumor_incidence0.81414166
137MP0010030_abnormal_orbit_morphology0.81351591
138MP0002723_abnormal_immune_serum0.80989297
139MP0003436_decreased_susceptibility_to0.80960091
140MP0002006_tumorigenesis0.78705436
141MP0003315_abnormal_perineum_morphology0.78323489
142MP0000598_abnormal_liver_morphology0.77777723
143MP0003119_abnormal_digestive_system0.77739903
144MP0003191_abnormal_cellular_cholesterol0.77610973
145MP0002398_abnormal_bone_marrow0.77207326
146MP0002429_abnormal_blood_cell0.77183349
147MP0003656_abnormal_erythrocyte_physiolo0.77049069
148MP0000383_abnormal_hair_follicle0.76316429
149MP0010352_gastrointestinal_tract_polyps0.75971388
150MP0003943_abnormal_hepatobiliary_system0.75546281
151MP0000613_abnormal_salivary_gland0.75390059
152MP0000716_abnormal_immune_system0.75281833
153MP0005389_reproductive_system_phenotype0.74649972
154MP0003283_abnormal_digestive_organ0.74367703
155MP0003937_abnormal_limbs/digits/tail_de0.74267664
156MP0001905_abnormal_dopamine_level0.73094150
157MP0009765_abnormal_xenobiotic_induced0.70778133
158MP0006276_abnormal_autonomic_nervous0.69013635
159MP0000230_abnormal_systemic_arterial0.67005292

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.42078765
2Acute encephalopathy (HP:0006846)4.33332264
3Mitochondrial inheritance (HP:0001427)4.07640409
4Abnormal mitochondria in muscle tissue (HP:0008316)3.99078124
5Increased CSF lactate (HP:0002490)3.81840283
6Progressive macrocephaly (HP:0004481)3.66622020
7Hepatocellular necrosis (HP:0001404)3.60704544
8Conjugated hyperbilirubinemia (HP:0002908)3.44113194
9Reticulocytopenia (HP:0001896)3.41562007
10Abnormality of cells of the erythroid lineage (HP:0012130)3.22447021
11Abnormal number of erythroid precursors (HP:0012131)3.21240003
12Cerebral edema (HP:0002181)3.08397752
13Reduced antithrombin III activity (HP:0001976)3.03482481
14Congenital, generalized hypertrichosis (HP:0004540)3.00758947
15Pancreatic cysts (HP:0001737)2.83161498
16Methylmalonic acidemia (HP:0002912)2.72841363
17Hypobetalipoproteinemia (HP:0003563)2.69502942
18Nausea (HP:0002018)2.68100433
19Aplastic anemia (HP:0001915)2.67618867
20Lactic acidosis (HP:0003128)2.67189943
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56437529
22Methylmalonic aciduria (HP:0012120)2.54519549
23Abnormality of pyrimidine metabolism (HP:0004353)2.54098811
24Pancreatic fibrosis (HP:0100732)2.53381245
25Increased intramyocellular lipid droplets (HP:0012240)2.53255749
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52385645
27Abnormality of midbrain morphology (HP:0002418)2.48987933
28Molar tooth sign on MRI (HP:0002419)2.48987933
29Elevated erythrocyte sedimentation rate (HP:0003565)2.44545659
30Hyperglycinuria (HP:0003108)2.43822430
31Generalized aminoaciduria (HP:0002909)2.40656135
32Abnormality of urine glucose concentration (HP:0011016)2.38498482
33Glycosuria (HP:0003076)2.38498482
34Respiratory failure (HP:0002878)2.36687404
35Ileus (HP:0002595)2.34880791
36Hyperglycinemia (HP:0002154)2.31265994
37Abnormality of the ileum (HP:0001549)2.30354964
38Macrocytic anemia (HP:0001972)2.30307565
39Prolonged partial thromboplastin time (HP:0003645)2.30095664
40Optic disc pallor (HP:0000543)2.28875432
41Thrombocytosis (HP:0001894)2.27525723
42Renal cortical cysts (HP:0000803)2.27415065
43True hermaphroditism (HP:0010459)2.25704149
44Rough bone trabeculation (HP:0100670)2.23934400
45Abnormality of fatty-acid metabolism (HP:0004359)2.22293956
46Abnormality of methionine metabolism (HP:0010901)2.19352096
47Increased muscle lipid content (HP:0009058)2.19345507
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.19208871
49Type I transferrin isoform profile (HP:0003642)2.18211771
50Absent thumb (HP:0009777)2.15185125
51Proximal tubulopathy (HP:0000114)2.14562401
52Posterior subcapsular cataract (HP:0007787)2.14019293
53Pustule (HP:0200039)2.12889195
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.11591579
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07939306
56Abnormality of alanine metabolism (HP:0010916)2.07939306
57Hyperalaninemia (HP:0003348)2.07939306
58Aplasia/hypoplasia of the uterus (HP:0008684)2.05936446
59Abnormal spermatogenesis (HP:0008669)2.05804515
60Abnormality of renal resorption (HP:0011038)2.05465286
61Abnormality of vitamin B metabolism (HP:0004340)2.03602597
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03184714
63Intrahepatic cholestasis (HP:0001406)2.03141507
64Pallor (HP:0000980)2.02895811
65Pancytopenia (HP:0001876)2.02408383
66Abnormality of the labia minora (HP:0012880)2.01326410
67Pendular nystagmus (HP:0012043)1.99671936
68Exercise intolerance (HP:0003546)1.99654311
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99276065
70Abnormal hemoglobin (HP:0011902)1.97396823
71Oral leukoplakia (HP:0002745)1.95334938
72Short tibia (HP:0005736)1.94852557
73Abolished electroretinogram (ERG) (HP:0000550)1.94405004
74Hypoglycemic coma (HP:0001325)1.93729954
75Fat malabsorption (HP:0002630)1.92183564
763-Methylglutaconic aciduria (HP:0003535)1.92142429
77Congenital stationary night blindness (HP:0007642)1.91706751
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90805302
79Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90695322
80Abnormality of serine family amino acid metabolism (HP:0010894)1.90688389
81Abnormality of glycine metabolism (HP:0010895)1.90688389
82Hepatic necrosis (HP:0002605)1.89963499
83Abnormality of chromosome stability (HP:0003220)1.89157227
84Abnormal biliary tract physiology (HP:0012439)1.88004825
85Bile duct proliferation (HP:0001408)1.88004825
86Petechiae (HP:0000967)1.87503325
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87359877
88Lipid accumulation in hepatocytes (HP:0006561)1.86892303
89Azoospermia (HP:0000027)1.86059672
90Median cleft lip (HP:0000161)1.85793792
91Respiratory difficulties (HP:0002880)1.84868990
92Duodenal stenosis (HP:0100867)1.84696911
93Small intestinal stenosis (HP:0012848)1.84696911
94Cerebral palsy (HP:0100021)1.84349566
95Autoimmune thrombocytopenia (HP:0001973)1.84267284
96Chromsome breakage (HP:0040012)1.83936345
97Nonimmune hydrops fetalis (HP:0001790)1.83593143
98Microretrognathia (HP:0000308)1.83427335
99Abnormal tarsal ossification (HP:0008369)1.83179190
100IgM deficiency (HP:0002850)1.82517043
101Medial flaring of the eyebrow (HP:0010747)1.82442504
102Sparse eyelashes (HP:0000653)1.82233315
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82224055
104Abnormality of serum amino acid levels (HP:0003112)1.81298693
105Vacuolated lymphocytes (HP:0001922)1.80892097
106Nephronophthisis (HP:0000090)1.80879300
107Hyperammonemia (HP:0001987)1.80706352
108Abnormality of the heme biosynthetic pathway (HP:0010472)1.80429595
109Hyperphosphaturia (HP:0003109)1.79554963
110Increased serum pyruvate (HP:0003542)1.77886538
11111 pairs of ribs (HP:0000878)1.77580993
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77499614
113Dicarboxylic aciduria (HP:0003215)1.77499614
114Increased hepatocellular lipid droplets (HP:0006565)1.77374940
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.77317942
116CNS demyelination (HP:0007305)1.75891258
117Delayed CNS myelination (HP:0002188)1.74897905
118Degeneration of anterior horn cells (HP:0002398)1.74482633
119Abnormality of the anterior horn cell (HP:0006802)1.74482633
120Leukodystrophy (HP:0002415)1.74402800
121Abnormal trabecular bone morphology (HP:0100671)1.74053778
122Exertional dyspnea (HP:0002875)1.73797889
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73696479
124Abnormality of the renal cortex (HP:0011035)1.73557016
125Hypolipoproteinemia (HP:0010981)1.73279762
126Hyperbilirubinemia (HP:0002904)1.73073828
127Triphalangeal thumb (HP:0001199)1.72276271
128Birth length less than 3rd percentile (HP:0003561)1.71343105
129Renal Fanconi syndrome (HP:0001994)1.69479841
130Cheilitis (HP:0100825)1.68722014
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68675451
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68675451
133Increased serum lactate (HP:0002151)1.68579536
134Colon cancer (HP:0003003)1.67646351
135Prolonged neonatal jaundice (HP:0006579)1.66925117
136Autoimmune hemolytic anemia (HP:0001890)1.65270030
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65076611
138Abnormality of nucleobase metabolism (HP:0010932)1.64795251
139Abnormal protein glycosylation (HP:0012346)1.64685627
140Abnormal glycosylation (HP:0012345)1.64685627
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64685627
142Abnormal protein N-linked glycosylation (HP:0012347)1.64685627
143Myositis (HP:0100614)1.64394036
144Breast hypoplasia (HP:0003187)1.64392968
145Irregular epiphyses (HP:0010582)1.62688565
146Abnormal foot bone ossification (HP:0010675)1.62178668
147Abnormality of the preputium (HP:0100587)1.61869644
148Abnormal pancreas size (HP:0012094)1.61852494
149Capillary hemangiomas (HP:0005306)1.61101703
150Stenosis of the external auditory canal (HP:0000402)1.58133550
151Lethargy (HP:0001254)1.57423991
152Multiple enchondromatosis (HP:0005701)1.57114414
153Ureteral duplication (HP:0000073)1.56731570
154Spontaneous hematomas (HP:0007420)1.55155181
155Chronic diarrhea (HP:0002028)1.54258043
156Meckel diverticulum (HP:0002245)1.54012040
157Xanthomatosis (HP:0000991)1.53613689
158Hepatocellular carcinoma (HP:0001402)1.52264945
159Steatorrhea (HP:0002570)1.51811919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.66374681
2NME23.28451316
3BUB12.93876564
4EIF2AK12.72170356
5STK162.53173706
6WNK32.17460081
7PIM22.16868564
8WEE12.15190500
9IRAK32.09125053
10* NUAK11.98238256
11IRAK41.95566032
12BCKDK1.92197494
13CDC71.92146945
14ZAK1.87903910
15MAP4K21.85976496
16NEK91.83326453
17KDR1.81717511
18TRIM281.80821739
19BRSK21.78501960
20MST41.75823578
21TNIK1.75555108
22MAP3K31.70103785
23TIE11.68013443
24NEK11.67315130
25PBK1.66315564
26FRK1.66094263
27NLK1.58216467
28TAOK21.52625741
29SRPK11.51667110
30TAOK31.48958188
31MAP4K11.48882056
32EIF2AK31.46966180
33VRK11.44008186
34STK241.41918189
35ADRBK21.40159397
36MAP3K111.39764603
37TESK21.33954562
38RPS6KA41.32821401
39TEC1.31019435
40DYRK31.27861416
41TBK11.27756693
42PLK41.23840367
43TGFBR11.20741529
44MAP3K141.18694037
45BLK1.18490105
46STK38L1.16972138
47OXSR11.15620974
48AURKB1.15028443
49TXK1.14132484
50AKT31.12569139
51NEK21.10771151
52TTK1.09683532
53EPHB21.09140202
54MYLK1.08658455
55CDK191.08280803
56CDK81.08248226
57STK101.08045468
58EPHA21.07327297
59KIT1.06762806
60TLK11.05751472
61MAP2K31.05364153
62EIF2AK21.04181250
63MKNK11.03536658
64TAF11.03050668
65ZAP701.02698908
66JAK30.99095666
67NME10.97949081
68TYK20.97851196
69MAP2K60.95940277
70FLT30.95462065
71PLK10.95446334
72TGFBR20.94400832
73PRKG20.93353566
74MAP3K120.93260613
75GRK10.89012539
76IKBKE0.88904187
77STK30.87779790
78PLK30.86947235
79BRSK10.86838667
80PDK20.85595249
81ACVR1B0.83861939
82PIK3CA0.82825870
83IKBKB0.82472642
84BTK0.82415537
85MKNK20.82198716
86PIM10.82103896
87CDK70.81752100
88MAP2K20.81079679
89DYRK20.80727109
90CSNK1G10.79279414
91TSSK60.78479097
92BMPR1B0.78009439
93MST1R0.76176682
94STK40.73007039
95LMTK20.71917559
96MAP3K80.69578366
97PASK0.68581164
98STK390.68029794
99DAPK10.67091584
100MAPK110.66781661
101CCNB10.66018945
102FGFR40.65864348
103CSNK1G30.65170997
104CLK10.62386258
105ATR0.62375672
106CHUK0.62075664
107CSNK2A10.61131787
108ABL20.60699920
109INSRR0.60374084
110CDK40.58824746
111CSNK1G20.55662131
112ERBB30.55320011
113RPS6KA50.54544572
114PAK40.52804037
115ITK0.52788715
116CSNK2A20.52784414
117CSF1R0.52192796
118RPS6KB20.52154683
119PLK20.51965807
120LRRK20.51221861
121AURKA0.50115987
122ATM0.49459696
123MUSK0.48990855
124CHEK20.47636619
125MAPKAPK50.46583261
126ILK0.46544708
127LIMK10.46480975
128IRAK10.45943831
129EPHA30.45661531
130PTK60.45446892
131ADRBK10.45429571
132LYN0.45362126
133TRPM70.44509020
134MAPKAPK30.41507999
135MATK0.40429772
136PRKCQ0.38616784
137PRKCI0.38570922
138SCYL20.38183777
139CHEK10.36682751
140TESK10.34371003
141PRKCE0.34028032
142GRK50.33330769
143WNK40.33147936
144CSNK1A10.32684994
145FER0.31281721

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.23933977
2Oxidative phosphorylation_Homo sapiens_hsa001903.09851621
3Proteasome_Homo sapiens_hsa030502.89660527
4RNA polymerase_Homo sapiens_hsa030202.35188441
5DNA replication_Homo sapiens_hsa030302.30090173
6Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96677419
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92671979
8Pyrimidine metabolism_Homo sapiens_hsa002401.89753012
9Mismatch repair_Homo sapiens_hsa034301.88747813
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88658006
11Folate biosynthesis_Homo sapiens_hsa007901.87149806
12Huntingtons disease_Homo sapiens_hsa050161.85041427
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82441262
14Vitamin digestion and absorption_Homo sapiens_hsa049771.79925345
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76459372
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.75106920
17Fatty acid elongation_Homo sapiens_hsa000621.73541523
18Homologous recombination_Homo sapiens_hsa034401.69606780
19Base excision repair_Homo sapiens_hsa034101.68941404
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68215147
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62006072
22Alzheimers disease_Homo sapiens_hsa050101.55727118
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53659856
24Spliceosome_Homo sapiens_hsa030401.53602004
25Nucleotide excision repair_Homo sapiens_hsa034201.49429095
26One carbon pool by folate_Homo sapiens_hsa006701.48529052
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46334687
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45574684
29Protein export_Homo sapiens_hsa030601.42962284
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39092868
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.37919688
32Caffeine metabolism_Homo sapiens_hsa002321.37424244
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34480239
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34444755
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34332698
36Retinol metabolism_Homo sapiens_hsa008301.30736539
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25188785
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.24966720
39Glutathione metabolism_Homo sapiens_hsa004801.23652365
40Chemical carcinogenesis_Homo sapiens_hsa052041.23395618
41Butanoate metabolism_Homo sapiens_hsa006501.22204100
42Basal transcription factors_Homo sapiens_hsa030221.21565013
43Fat digestion and absorption_Homo sapiens_hsa049751.18528552
44RNA transport_Homo sapiens_hsa030131.14841878
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.14268383
46Cell cycle_Homo sapiens_hsa041101.13876231
47Fatty acid degradation_Homo sapiens_hsa000711.13676722
48Peroxisome_Homo sapiens_hsa041461.12390386
49Pentose phosphate pathway_Homo sapiens_hsa000301.10117635
50Tryptophan metabolism_Homo sapiens_hsa003801.10010777
51Starch and sucrose metabolism_Homo sapiens_hsa005001.08314932
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08129747
53Selenocompound metabolism_Homo sapiens_hsa004501.07160955
54Nitrogen metabolism_Homo sapiens_hsa009101.05202029
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01672132
56Fanconi anemia pathway_Homo sapiens_hsa034600.99831727
57Histidine metabolism_Homo sapiens_hsa003400.99692042
58Non-homologous end-joining_Homo sapiens_hsa034500.99449580
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98145887
60Linoleic acid metabolism_Homo sapiens_hsa005910.95499556
61Purine metabolism_Homo sapiens_hsa002300.93986948
62Complement and coagulation cascades_Homo sapiens_hsa046100.93963265
63Pyruvate metabolism_Homo sapiens_hsa006200.93527661
64beta-Alanine metabolism_Homo sapiens_hsa004100.93367908
65Sulfur relay system_Homo sapiens_hsa041220.90988545
66Primary immunodeficiency_Homo sapiens_hsa053400.90807207
67Herpes simplex infection_Homo sapiens_hsa051680.90420114
68Galactose metabolism_Homo sapiens_hsa000520.89017145
69Sulfur metabolism_Homo sapiens_hsa009200.88477855
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87947822
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.87398973
72Legionellosis_Homo sapiens_hsa051340.87051613
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85783794
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85529178
75p53 signaling pathway_Homo sapiens_hsa041150.85442795
76Steroid biosynthesis_Homo sapiens_hsa001000.84524421
77Arachidonic acid metabolism_Homo sapiens_hsa005900.83309999
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83084759
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80753239
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.80394398
81RNA degradation_Homo sapiens_hsa030180.79880799
82Vitamin B6 metabolism_Homo sapiens_hsa007500.77540828
83Cardiac muscle contraction_Homo sapiens_hsa042600.77322311
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76121365
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.72280696
86Propanoate metabolism_Homo sapiens_hsa006400.72068485
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69609842
88Antigen processing and presentation_Homo sapiens_hsa046120.69053395
89Hematopoietic cell lineage_Homo sapiens_hsa046400.67413046
90Staphylococcus aureus infection_Homo sapiens_hsa051500.66473268
91Fatty acid metabolism_Homo sapiens_hsa012120.65450722
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64172224
93Phototransduction_Homo sapiens_hsa047440.63729581
94Arginine and proline metabolism_Homo sapiens_hsa003300.62988667
95Epstein-Barr virus infection_Homo sapiens_hsa051690.62345841
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.61888126
97Renin-angiotensin system_Homo sapiens_hsa046140.61511410
98Fructose and mannose metabolism_Homo sapiens_hsa000510.61422270
99Carbon metabolism_Homo sapiens_hsa012000.60011675
100Regulation of autophagy_Homo sapiens_hsa041400.59326152
101Measles_Homo sapiens_hsa051620.59141877
102Graft-versus-host disease_Homo sapiens_hsa053320.57984983
103Allograft rejection_Homo sapiens_hsa053300.57278495
104Metabolic pathways_Homo sapiens_hsa011000.55786456
105Asthma_Homo sapiens_hsa053100.53284541
106Influenza A_Homo sapiens_hsa051640.52980914
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52975265
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51954883
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50309461
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50260708
111PPAR signaling pathway_Homo sapiens_hsa033200.50236593
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48271315
113ABC transporters_Homo sapiens_hsa020100.47672307
114Tyrosine metabolism_Homo sapiens_hsa003500.46765342
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46460656
116Biosynthesis of amino acids_Homo sapiens_hsa012300.44973036
117Leishmaniasis_Homo sapiens_hsa051400.43061547
118Malaria_Homo sapiens_hsa051440.43034085
119N-Glycan biosynthesis_Homo sapiens_hsa005100.42301280
120Mineral absorption_Homo sapiens_hsa049780.41309363
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41203421
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40116782
123Arginine biosynthesis_Homo sapiens_hsa002200.39091665
124Pertussis_Homo sapiens_hsa051330.37967705
125Parkinsons disease_Homo sapiens_hsa050120.37581123
126Ether lipid metabolism_Homo sapiens_hsa005650.36544388
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35371218
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29206069
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28146257
130Glycerolipid metabolism_Homo sapiens_hsa005610.27217198

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