CASP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61610707
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61610707
3regulation of vitamin metabolic process (GO:0030656)4.55697427
4antigen processing and presentation of endogenous antigen (GO:0019883)4.15226969
5regulation of vitamin D biosynthetic process (GO:0060556)3.93901750
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.86068796
7intestinal cholesterol absorption (GO:0030299)3.77965213
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72094812
9intestinal absorption (GO:0050892)3.56857784
10phospholipid efflux (GO:0033700)3.54039658
11neutrophil activation involved in immune response (GO:0002283)3.49265295
12regulation of cholesterol esterification (GO:0010872)3.35840242
13regulation of triglyceride catabolic process (GO:0010896)3.35505946
14positive regulation of type 2 immune response (GO:0002830)3.32970154
15positive regulation of interferon-alpha production (GO:0032727)3.24893119
16angiotensin maturation (GO:0002003)3.23453947
17low-density lipoprotein particle clearance (GO:0034383)3.22897867
18plasma lipoprotein particle assembly (GO:0034377)3.22140900
19T-helper 1 type immune response (GO:0042088)3.21954557
20regulation of cytokine secretion involved in immune response (GO:0002739)3.19599623
21regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18491953
22urea cycle (GO:0000050)3.12481219
23urea metabolic process (GO:0019627)3.12481219
24production of molecular mediator involved in inflammatory response (GO:0002532)3.11955807
25plasma lipoprotein particle clearance (GO:0034381)3.10057530
26glycosphingolipid catabolic process (GO:0046479)3.09088062
27high-density lipoprotein particle remodeling (GO:0034375)3.07347357
28regulation of interferon-alpha production (GO:0032647)3.03923975
29indole-containing compound catabolic process (GO:0042436)3.03104421
30indolalkylamine catabolic process (GO:0046218)3.03104421
31tryptophan catabolic process (GO:0006569)3.03104421
32negative regulation of sterol transport (GO:0032372)3.03092602
33negative regulation of cholesterol transport (GO:0032375)3.03092602
34glycolipid catabolic process (GO:0019377)3.00527797
35interferon-gamma-mediated signaling pathway (GO:0060333)3.00374240
36bile acid and bile salt transport (GO:0015721)2.99146321
37Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98126548
38immunoglobulin mediated immune response (GO:0016064)2.98106956
39plasma lipoprotein particle remodeling (GO:0034369)2.96764561
40protein-lipid complex remodeling (GO:0034368)2.96764561
41macromolecular complex remodeling (GO:0034367)2.96764561
42kynurenine metabolic process (GO:0070189)2.96011016
43reactive oxygen species biosynthetic process (GO:1903409)2.95789473
44hydrogen peroxide biosynthetic process (GO:0050665)2.93139139
45response to peptidoglycan (GO:0032494)2.91604806
46protein-lipid complex assembly (GO:0065005)2.91112766
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90854691
48tryptophan metabolic process (GO:0006568)2.89363984
49positive regulation of triglyceride lipase activity (GO:0061365)2.87785763
50positive regulation of lipoprotein lipase activity (GO:0051006)2.87785763
51regulation of T-helper 1 cell differentiation (GO:0045625)2.87323766
52eosinophil chemotaxis (GO:0048245)2.86351892
53cholesterol efflux (GO:0033344)2.85440258
54flavonoid metabolic process (GO:0009812)2.85097197
55positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84481939
56reverse cholesterol transport (GO:0043691)2.83276068
57negative regulation of cytokine production involved in immune response (GO:0002719)2.82921374
58aromatic amino acid family catabolic process (GO:0009074)2.82641181
59cellular response to interferon-beta (GO:0035458)2.80834994
60response to type I interferon (GO:0034340)2.79221231
61nitrogen cycle metabolic process (GO:0071941)2.79110073
62cellular response to type I interferon (GO:0071357)2.78843094
63type I interferon signaling pathway (GO:0060337)2.78843094
64regulation of interferon-beta biosynthetic process (GO:0045357)2.76989861
65positive regulation of pseudopodium assembly (GO:0031274)2.76230262
66virion attachment to host cell (GO:0019062)2.76162083
67adhesion of symbiont to host cell (GO:0044650)2.76162083
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75409179
69L-phenylalanine metabolic process (GO:0006558)2.75409179
70NIK/NF-kappaB signaling (GO:0038061)2.74090952
71lipoprotein metabolic process (GO:0042157)2.73770305
72response to interferon-beta (GO:0035456)2.73495177
73killing of cells of other organism (GO:0031640)2.73164109
74disruption of cells of other organism (GO:0044364)2.73164109
75respiratory burst (GO:0045730)2.72749432
76modulation by symbiont of host immune response (GO:0052553)2.71640050
77positive regulation by symbiont of host defense response (GO:0052509)2.71640050
78modulation by symbiont of host defense response (GO:0052031)2.71640050
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71640050
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71640050
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.71640050
82regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.71380270
83regulation of T cell mediated cytotoxicity (GO:0001914)2.71077554
84neutrophil activation (GO:0042119)2.70796293
85regulation of cellular extravasation (GO:0002691)2.70150543
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.70140261
87L-phenylalanine catabolic process (GO:0006559)2.70042637
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70042637
89plasma lipoprotein particle organization (GO:0071827)2.69459989
90regulation of cholesterol storage (GO:0010885)2.68937308
91peptidyl-glutamic acid carboxylation (GO:0017187)2.68681416
92protein carboxylation (GO:0018214)2.68681416
93very-low-density lipoprotein particle assembly (GO:0034379)2.68421639
94regulation of chronic inflammatory response (GO:0002676)2.67862030
95cellular glucuronidation (GO:0052695)2.66798476
96complement activation, alternative pathway (GO:0006957)2.66717372
97sulfur amino acid catabolic process (GO:0000098)2.65761052
98regulation of antigen processing and presentation (GO:0002577)2.65688615
99low-density lipoprotein particle remodeling (GO:0034374)2.65224612
100granulocyte activation (GO:0036230)2.64680221
101disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.64330957
102killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.64330957
103cellular response to exogenous dsRNA (GO:0071360)2.63940423
104regulation of interleukin-12 biosynthetic process (GO:0045075)2.63838359
105alpha-linolenic acid metabolic process (GO:0036109)2.63647113
106negative regulation of myeloid cell apoptotic process (GO:0033033)2.60804773
107positive regulation of tolerance induction (GO:0002645)2.59482234
108cholesterol homeostasis (GO:0042632)2.58341968
109positive regulation of lipid catabolic process (GO:0050996)2.58158688
110hormone catabolic process (GO:0042447)2.58103825
111phospholipid homeostasis (GO:0055091)2.57775894
112uronic acid metabolic process (GO:0006063)2.57123078
113glucuronate metabolic process (GO:0019585)2.57123078
114regulation of podosome assembly (GO:0071801)2.56630916
115response to muramyl dipeptide (GO:0032495)2.56267752
116positive regulation of antigen processing and presentation (GO:0002579)2.56187280
117regulation of T cell tolerance induction (GO:0002664)2.56167615
118lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55729248
119regulation of metalloenzyme activity (GO:0048552)2.55670835
120negative regulation of viral genome replication (GO:0045071)2.55451467
121cellular response to interferon-gamma (GO:0071346)2.55361214
122protein-lipid complex subunit organization (GO:0071825)2.54842421
123fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54744332
124interferon-gamma secretion (GO:0072643)2.54028024
125sterol homeostasis (GO:0055092)2.53500726
126myeloid dendritic cell differentiation (GO:0043011)2.52730697
127ceramide catabolic process (GO:0046514)2.52605014
128regulation of activation of Janus kinase activity (GO:0010533)2.52106250
129desmosome organization (GO:0002934)2.51154725
130positive regulation of gamma-delta T cell activation (GO:0046645)2.50781335
131eosinophil migration (GO:0072677)2.49591829
132regulation of RIG-I signaling pathway (GO:0039535)2.49529650
133response to fungus (GO:0009620)2.49195928
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.48636987
135regulation of tolerance induction (GO:0002643)2.48239185
136acute-phase response (GO:0006953)2.47650592
137regulation of chemokine biosynthetic process (GO:0045073)2.45860301
138negative regulation of interleukin-12 production (GO:0032695)2.45645468
139negative regulation of cell killing (GO:0031342)2.45135665
140negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45135665
141positive regulation of neutrophil migration (GO:1902624)2.44645484
142positive regulation of neutrophil chemotaxis (GO:0090023)2.44645484
143adhesion of symbiont to host (GO:0044406)2.41864625
144regulation of pseudopodium assembly (GO:0031272)2.41642718
145response to interferon-gamma (GO:0034341)2.41003274
146B cell mediated immunity (GO:0019724)2.39914447
147positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.39008197
148sexual reproduction (GO:0019953)2.38979876
149lymphocyte chemotaxis (GO:0048247)2.37360758
150fat-soluble vitamin biosynthetic process (GO:0042362)2.36884390
151negative regulation of production of molecular mediator of immune response (GO:0002701)2.32327009
152positive regulation of granulocyte chemotaxis (GO:0071624)2.32231702
153chaperone mediated protein folding requiring cofactor (GO:0051085)2.31687675
154macrophage activation involved in immune response (GO:0002281)2.31373294
155regulation of leukocyte mediated cytotoxicity (GO:0001910)2.30087518
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.29193436
157GDP-mannose metabolic process (GO:0019673)2.28977355
158regulation of alpha-beta T cell proliferation (GO:0046640)2.28965142
159regulation of regulatory T cell differentiation (GO:0045589)2.28298558
160negative regulation of T cell mediated immunity (GO:0002710)2.27757476
161maintenance of gastrointestinal epithelium (GO:0030277)2.27561871
162positive regulation of alpha-beta T cell proliferation (GO:0046641)2.26955058
163germinal center formation (GO:0002467)2.26458445
164membrane lipid catabolic process (GO:0046466)2.25199941
165cellular response to interferon-alpha (GO:0035457)2.24875153
166thrombin receptor signaling pathway (GO:0070493)2.24112398
167regulation of type 2 immune response (GO:0002828)2.22507493
168regulation of gamma-delta T cell activation (GO:0046643)2.22480387
169regulation of T cell chemotaxis (GO:0010819)2.21907875
170positive regulation of T cell chemotaxis (GO:0010820)2.21907875
171regulation of viral release from host cell (GO:1902186)2.20681060
172sphingolipid catabolic process (GO:0030149)2.20041506
173regulation of mononuclear cell migration (GO:0071675)2.19943547
174positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.19056800
175defense response to virus (GO:0051607)2.18827066
176myeloid dendritic cell activation (GO:0001773)2.18598810
177antigen processing and presentation via MHC class Ib (GO:0002475)2.16860954
178positive regulation of chemokine biosynthetic process (GO:0045080)2.16855907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.25723704
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15315164
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.90107270
4E2F7_22180533_ChIP-Seq_HELA_Human3.83699810
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68798762
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.64640450
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.49838093
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34691338
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.28488915
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09760680
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83081410
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.79571780
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.58433487
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56029512
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51607692
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.48986611
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42455962
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40767737
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39617271
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36964492
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36927776
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34913803
23GATA1_22025678_ChIP-Seq_K562_Human2.26120947
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.20909405
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02336706
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00521788
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00474038
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.98981948
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96242659
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89368083
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88287465
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88003682
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86769970
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.85665992
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83464913
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79508329
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72121143
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69751005
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.67628498
40SCL_19346495_ChIP-Seq_HPC-7_Human1.66199698
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64346814
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.59876937
43* SPI1_23547873_ChIP-Seq_NB4_Human1.59780469
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51804229
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.46125619
46* MAF_26560356_Chip-Seq_TH1_Human1.43225407
47MYB_26560356_Chip-Seq_TH2_Human1.40439709
48VDR_21846776_ChIP-Seq_THP-1_Human1.38986109
49* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38201826
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37726915
51VDR_24763502_ChIP-Seq_THP-1_Human1.37661923
52ZNF263_19887448_ChIP-Seq_K562_Human1.36972324
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36520527
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31872306
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29056848
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28901910
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.28836190
58GATA4_25053715_ChIP-Seq_YYC3_Human1.28430896
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28116649
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.27735697
61* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27021495
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26718321
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.26303619
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25176790
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25090341
66MYB_26560356_Chip-Seq_TH1_Human1.22969887
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22219004
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22202221
69* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20489665
70* PU_27001747_Chip-Seq_BMDM_Mouse1.19854542
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19654791
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19436606
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19436606
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16111869
75RACK7_27058665_Chip-Seq_MCF-7_Human1.14104361
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14081426
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11709433
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11586151
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10659099
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10582249
81* SOX2_20726797_ChIP-Seq_SW620_Human1.08860881
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08488703
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07148147
84UTX_26944678_Chip-Seq_JUKART_Human1.05741788
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03731567
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02803824
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02401969
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02358531
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.01476071
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01395901
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01173805
92RUNX_20019798_ChIP-Seq_JUKART_Human1.01024769
93AR_21909140_ChIP-Seq_LNCAP_Human0.98164724
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97855823
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97615827
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.96742939
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96538461
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96008707
99ATF3_27146783_Chip-Seq_COLON_Human0.95383882
100GATA6_25053715_ChIP-Seq_YYC3_Human0.95334530
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94355606
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93717844
103STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93567328
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93333020
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92837372
106* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92261181
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91086938
108CLOCK_20551151_ChIP-Seq_293T_Human0.90745303
109ELF5_23300383_ChIP-Seq_T47D_Human0.90327940
110* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89771071
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.88443363
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88250556
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86781093
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86545741
115VDR_24787735_ChIP-Seq_THP-1_Human0.86311947
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85505515
117MYC_22102868_ChIP-Seq_BL_Human0.85487012
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84827827
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83906687
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83906244
121GATA2_19941826_ChIP-Seq_K562_Human0.83325646
122SPI1_23127762_ChIP-Seq_K562_Human0.82947440
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82621251
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82521870
125GATA3_26560356_Chip-Seq_TH2_Human0.82397674
126GATA3_27048872_Chip-Seq_THYMUS_Human0.82069257
127SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81958859
128TCF7_22412390_ChIP-Seq_EML_Mouse0.81798623
129* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81743586
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78141416
131MAF_26560356_Chip-Seq_TH2_Human0.78026873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.95809562
2MP0002139_abnormal_hepatobiliary_system3.69662129
3MP0001835_abnormal_antigen_presentation3.01853733
4MP0005085_abnormal_gallbladder_physiolo3.01468002
5MP0009785_altered_susceptibility_to2.91822770
6MP0003436_decreased_susceptibility_to2.75772799
7MP0005365_abnormal_bile_salt2.69753778
8MP0008875_abnormal_xenobiotic_pharmacok2.57132198
9MP0009840_abnormal_foam_cell2.50101258
10MP0003252_abnormal_bile_duct2.41838475
11MP0001666_abnormal_nutrient_absorption2.30185391
12MP0003724_increased_susceptibility_to2.28128294
13MP0002148_abnormal_hypersensitivity_rea2.26542683
14MP0003191_abnormal_cellular_cholesterol2.21134297
15MP0005025_abnormal_response_to2.19993129
16MP0003303_peritoneal_inflammation2.06513853
17MP0002419_abnormal_innate_immunity2.06414641
18MP0000685_abnormal_immune_system2.03905118
19MP0005000_abnormal_immune_tolerance1.99293265
20MP0003806_abnormal_nucleotide_metabolis1.97818924
21MP0010155_abnormal_intestine_physiology1.97040323
22MP0010329_abnormal_lipoprotein_level1.91390506
23MP0001853_heart_inflammation1.81319857
24MP0003183_abnormal_peptide_metabolism1.80329157
25MP0010234_abnormal_vibrissa_follicle1.79358218
26MP0005464_abnormal_platelet_physiology1.75411205
27MP0002452_abnormal_antigen_presenting1.73277451
28MP0001790_abnormal_immune_system1.70709702
29MP0005387_immune_system_phenotype1.70709702
30MP0010352_gastrointestinal_tract_polyps1.70403159
31MP0002877_abnormal_melanocyte_morpholog1.68839508
32MP0001800_abnormal_humoral_immune1.68536756
33MP0004947_skin_inflammation1.68484542
34MP0009764_decreased_sensitivity_to1.66939206
35MP0002006_tumorigenesis1.63541181
36MP0002723_abnormal_immune_serum1.60580667
37MP0005671_abnormal_response_to1.58103213
38MP0006082_CNS_inflammation1.55737415
39MP0001845_abnormal_inflammatory_respons1.54137124
40MP0008469_abnormal_protein_level1.52487704
41MP0001819_abnormal_immune_cell1.49959487
42MP0009278_abnormal_bone_marrow1.49311779
43MP0002166_altered_tumor_susceptibility1.47945374
44MP0002420_abnormal_adaptive_immunity1.47275717
45MP0001545_abnormal_hematopoietic_system1.47008940
46MP0005397_hematopoietic_system_phenotyp1.47008940
47MP0003186_abnormal_redox_activity1.46876409
48MP0003300_gastrointestinal_ulcer1.44650269
49MP0000609_abnormal_liver_physiology1.44221344
50MP0001533_abnormal_skeleton_physiology1.43546067
51MP0005167_abnormal_blood-brain_barrier1.39469462
52MP0002138_abnormal_hepatobiliary_system1.31875433
53MP0002405_respiratory_system_inflammati1.29216101
54MP0004782_abnormal_surfactant_physiolog1.28509084
55MP0004019_abnormal_vitamin_homeostasis1.25190134
56MP0003866_abnormal_defecation1.22943495
57MP0009333_abnormal_splenocyte_physiolog1.22605713
58MP0005319_abnormal_enzyme/_coenzyme1.22373487
59MP0003868_abnormal_feces_composition1.20927041
60MP0001873_stomach_inflammation1.17596210
61MP0005083_abnormal_biliary_tract1.17432586
62MP0000716_abnormal_immune_system1.12850414
63MP0009697_abnormal_copulation1.10749847
64MP0000490_abnormal_crypts_of1.10122158
65MP0009763_increased_sensitivity_to1.09980367
66MP0009643_abnormal_urine_homeostasis1.07936836
67MP0002398_abnormal_bone_marrow1.07855697
68MP0005165_increased_susceptibility_to1.06252077
69MP0003705_abnormal_hypodermis_morpholog1.05388377
70MP0000858_altered_metastatic_potential1.05269128
71MP0006054_spinal_hemorrhage1.03737366
72MP0003091_abnormal_cell_migration1.03182903
73MP0005332_abnormal_amino_acid1.01382031
74MP0005164_abnormal_response_to1.00581564
75MP0002429_abnormal_blood_cell1.00139989
76MP0004043_abnormal_pH_regulation1.00068643
77MP0000689_abnormal_spleen_morphology0.97428499
78MP0001764_abnormal_homeostasis0.97247983
79MP0003448_altered_tumor_morphology0.96915878
80MP0002722_abnormal_immune_system0.93951968
81MP0005023_abnormal_wound_healing0.93740153
82MP0002254_reproductive_system_inflammat0.93689711
83MP0003075_altered_response_to0.93301097
84MP0000598_abnormal_liver_morphology0.93054273
85MP0002396_abnormal_hematopoietic_system0.92854481
86MP0002132_abnormal_respiratory_system0.92718958
87MP0002118_abnormal_lipid_homeostasis0.92650736
88MP0004264_abnormal_extraembryonic_tissu0.92525957
89MP0005584_abnormal_enzyme/coenzyme_acti0.90560510
90MP0001663_abnormal_digestive_system0.89103656
91MP0005166_decreased_susceptibility_to0.87125752
92MP0001216_abnormal_epidermal_layer0.86979469
93MP0003656_abnormal_erythrocyte_physiolo0.85474337
94MP0000343_altered_response_to0.85091561
95MP0003453_abnormal_keratinocyte_physiol0.84412632
96MP0009765_abnormal_xenobiotic_induced0.83407372
97MP0002136_abnormal_kidney_physiology0.83324411
98MP0004808_abnormal_hematopoietic_stem0.82411913
99MP0005381_digestive/alimentary_phenotyp0.81730235
100MP0000465_gastrointestinal_hemorrhage0.80706102
101MP0003763_abnormal_thymus_physiology0.80312553
102MP0002796_impaired_skin_barrier0.80152365
103MP0002876_abnormal_thyroid_physiology0.79266234
104MP0005058_abnormal_lysosome_morphology0.77959022
105MP0005084_abnormal_gallbladder_morpholo0.77875143
106MP0000249_abnormal_blood_vessel0.77157624
107MP0010678_abnormal_skin_adnexa0.77089813
108MP0002998_abnormal_bone_remodeling0.76958489
109MP0005310_abnormal_salivary_gland0.76919964
110MP0008004_abnormal_stomach_pH0.76635339
111MP0003950_abnormal_plasma_membrane0.75366783
112MP0000477_abnormal_intestine_morphology0.74477530
113MP0001879_abnormal_lymphatic_vessel0.74002776
114MP0002933_joint_inflammation0.73783703
115MP0005670_abnormal_white_adipose0.73026764
116MP0010307_abnormal_tumor_latency0.72994856
117MP0004883_abnormal_blood_vessel0.72840503
118MP0004185_abnormal_adipocyte_glucose0.71697970
119MP0008873_increased_physiological_sensi0.71402410
120MP0005451_abnormal_body_composition0.71232292
121MP0001765_abnormal_ion_homeostasis0.70883331
122MP0005636_abnormal_mineral_homeostasis0.70704422

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.15104391
2Eczematoid dermatitis (HP:0000976)4.10248724
3Recurrent abscess formation (HP:0002722)4.07511206
4Autoimmune thrombocytopenia (HP:0001973)3.99265951
5Elevated erythrocyte sedimentation rate (HP:0003565)3.86215281
6Recurrent bacterial skin infections (HP:0005406)3.76626956
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.74600823
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.66903091
9Hypobetalipoproteinemia (HP:0003563)3.66035079
10Intrahepatic cholestasis (HP:0001406)3.56420951
11Hypoglycemic coma (HP:0001325)3.27314413
12Gastrointestinal infarctions (HP:0005244)3.24311876
13Xanthomatosis (HP:0000991)3.14238123
14Myositis (HP:0100614)3.13599241
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.13222312
16Orchitis (HP:0100796)3.13019574
17Systemic lupus erythematosus (HP:0002725)3.06334229
18Petechiae (HP:0000967)3.05955342
19Abnormality of macrophages (HP:0004311)3.04021951
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.03999074
21Prolonged partial thromboplastin time (HP:0003645)3.03919483
22Deep venous thrombosis (HP:0002625)3.01881138
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.01290628
24Hyperactive renin-angiotensin system (HP:0000841)2.99201418
25Keratoconjunctivitis (HP:0001096)2.98941400
26Increased IgM level (HP:0003496)2.95196702
27Malnutrition (HP:0004395)2.94290418
28Pustule (HP:0200039)2.92105329
29Joint hemorrhage (HP:0005261)2.90567906
30Esophageal varix (HP:0002040)2.81709924
31Mediastinal lymphadenopathy (HP:0100721)2.79967191
32Optic neuritis (HP:0100653)2.78771158
33Retrobulbar optic neuritis (HP:0100654)2.78771158
34Abnormality of the common coagulation pathway (HP:0010990)2.74507588
35Fat malabsorption (HP:0002630)2.73666845
36Hydroxyprolinuria (HP:0003080)2.73299697
37Abnormality of proline metabolism (HP:0010907)2.73299697
38Hemoptysis (HP:0002105)2.72840723
39Vacuolated lymphocytes (HP:0001922)2.70570962
40Hypoglycemic seizures (HP:0002173)2.66458602
41Chronic otitis media (HP:0000389)2.66195085
42Recurrent viral infections (HP:0004429)2.62602830
43Gingivitis (HP:0000230)2.59813648
44Vasculitis (HP:0002633)2.59238097
45Gangrene (HP:0100758)2.58697055
46Hypercholesterolemia (HP:0003124)2.58000005
47Flat acetabular roof (HP:0003180)2.54827011
48Gingival bleeding (HP:0000225)2.52675960
49Abnormality of glycolipid metabolism (HP:0010969)2.51955366
50Abnormality of liposaccharide metabolism (HP:0010968)2.51955366
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.51955366
52Autoimmune hemolytic anemia (HP:0001890)2.51540616
53Pigmentary retinal degeneration (HP:0001146)2.48843563
54Abnormality of pyrimidine metabolism (HP:0004353)2.48014509
55Periodontitis (HP:0000704)2.47820585
56Hyperammonemia (HP:0001987)2.46575539
57Hypolipoproteinemia (HP:0010981)2.44668489
58Conjugated hyperbilirubinemia (HP:0002908)2.44455102
59Recurrent fungal infections (HP:0002841)2.41822420
60Hypergammaglobulinemia (HP:0010702)2.41327936
61Acanthocytosis (HP:0001927)2.41108840
62Recurrent bronchitis (HP:0002837)2.40007909
63Myocardial infarction (HP:0001658)2.39367646
64Thrombophlebitis (HP:0004418)2.38325865
65Abnormality of small intestinal villus morphology (HP:0011472)2.36304359
66Villous atrophy (HP:0011473)2.36304359
67Arterial thrombosis (HP:0004420)2.34049402
68Recurrent skin infections (HP:0001581)2.31407830
69Polycythemia (HP:0001901)2.31270869
70Thrombocytosis (HP:0001894)2.30444037
71Epidermoid cyst (HP:0200040)2.25281130
72Abnormal platelet volume (HP:0011876)2.25025581
73Complement deficiency (HP:0004431)2.24905338
74Ileus (HP:0002595)2.24485852
75Peritonitis (HP:0002586)2.24422849
76Encephalitis (HP:0002383)2.24191686
77Reduced antithrombin III activity (HP:0001976)2.23596295
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23508331
79Abnormality of T cell physiology (HP:0011840)2.21401794
80Hemorrhage of the eye (HP:0011885)2.20803422
81Urticaria (HP:0001025)2.20458667
82Increased mean platelet volume (HP:0011877)2.17014012
83Abnormality of T cell number (HP:0011839)2.16655548
84Epistaxis (HP:0000421)2.16502392
85Chronic diarrhea (HP:0002028)2.13479457
86Abnormality of B cell number (HP:0010975)2.13332309
87Pulmonary embolism (HP:0002204)2.12868655
88Hyperbilirubinemia (HP:0002904)2.12116830
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.11562263
90Colitis (HP:0002583)2.11533743
91Leukocytosis (HP:0001974)2.09302376
92Nausea (HP:0002018)2.09192542
93Nephritis (HP:0000123)2.09137728
94Spontaneous hematomas (HP:0007420)2.09049231
95Congenital sensorineural hearing impairment (HP:0008527)2.08851385
96Hematochezia (HP:0002573)2.08661389
97Menorrhagia (HP:0000132)2.08125832
98Keratoconjunctivitis sicca (HP:0001097)2.07382957
99Interstitial pulmonary disease (HP:0006530)2.05456178
100Cellulitis (HP:0100658)2.05205863
101Recurrent cutaneous fungal infections (HP:0011370)2.04810296
102Chronic mucocutaneous candidiasis (HP:0002728)2.04810296
103Abnormality of nucleobase metabolism (HP:0010932)2.04718589
104Purpura (HP:0000979)2.04370606
105Basal ganglia calcification (HP:0002135)2.03390068
106Meningitis (HP:0001287)2.02947644
107Poikilocytosis (HP:0004447)2.02640494
108Hyperlipoproteinemia (HP:0010980)2.01990558
109Combined immunodeficiency (HP:0005387)2.01818192
110Glomerulonephritis (HP:0000099)2.01428861
111Abnormality of the intrinsic pathway (HP:0010989)2.01407180
112Pulmonary infiltrates (HP:0002113)2.01118283
113Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00910078
114Abnormality of complement system (HP:0005339)2.00173086
115Stomatitis (HP:0010280)1.99551030
116Pancreatitis (HP:0001733)1.99210465
117Abnormality of the pleura (HP:0002103)1.98982897
118Joint swelling (HP:0001386)1.97712777
119Granulocytopenia (HP:0001913)1.96933237
120Thin bony cortex (HP:0002753)1.96223189
121Abnormal tarsal ossification (HP:0008369)1.95707960
122Abnormality of the nasal mucosa (HP:0000433)1.95448314
123Symptomatic seizures (HP:0011145)1.95361010
124Abdominal distention (HP:0003270)1.94831632
125Amyloidosis (HP:0011034)1.94795096
126Anorexia (HP:0002039)1.94256951
127Abnormal glucose tolerance (HP:0001952)1.93951240
128Cheilitis (HP:0100825)1.93159057
129Bronchitis (HP:0012387)1.92958540
130Nasal polyposis (HP:0100582)1.92765410
131Abnormality of iron homeostasis (HP:0011031)1.92238286
132Abnormality of the distal phalanges of the toes (HP:0010182)1.91735377
133Abnormality of transition element cation homeostasis (HP:0011030)1.91619650
134Hyperparathyroidism (HP:0000843)1.91525501
135Abnormality of the pericardium (HP:0001697)1.91137495
136Decreased circulating renin level (HP:0003351)1.87407677
137Alkalosis (HP:0001948)1.86978653
138Metabolic alkalosis (HP:0200114)1.84504418
139Glucose intolerance (HP:0000833)1.84273307
140Osteolytic defects of the hand bones (HP:0009699)1.83450414
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.83450414
142Abnormality of T cells (HP:0002843)1.83239683
143Loss of speech (HP:0002371)1.82576455
144Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82043397
145Inflammation of the large intestine (HP:0002037)1.81722360
146Dysostosis multiplex (HP:0000943)1.81670693
147Steatorrhea (HP:0002570)1.80721487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.26900861
2MAP3K143.23282271
3TAOK33.04115135
4MAP3K122.98279729
5BLK2.84066965
6EPHA22.67140367
7MST1R2.53340825
8TYK22.51161553
9MAP3K102.47924927
10MAP4K12.42338027
11MST42.40109366
12ERN12.36429895
13IKBKE2.33747633
14FRK2.30314966
15KDR2.19609747
16IRAK42.15784100
17RIPK42.13096305
18JAK32.01966663
19IKBKB1.98279303
20PBK1.74948926
21PRPF4B1.65586815
22IRAK31.59016652
23KIT1.50139811
24STK101.44937419
25FLT31.44535502
26BTK1.44192428
27FGFR41.43856377
28GRK61.42428036
29PKN21.42414455
30PIM21.42284545
31BCKDK1.40946462
32TEC1.37372412
33GRK71.37247652
34TESK21.37189682
35JAK11.35993293
36ZAP701.35892327
37MAP2K31.32463106
38TXK1.32458850
39TIE11.26666726
40TGFBR11.26045763
41TESK11.22476111
42NME21.17673038
43CHUK1.17040440
44NEK91.15918486
45TAOK21.15817468
46PRKG21.15812627
47PIM11.15099165
48FGR1.14604081
49PTK61.09659824
50RPS6KA41.08329910
51BMX1.08323842
52TGFBR21.06464585
53CSK1.05549843
54JAK21.03289206
55MAP2K21.02877855
56EIF2AK11.02714673
57LRRK21.02144610
58EPHB21.01828827
59MATK1.01606620
60FER0.98673504
61DDR20.97656408
62ABL20.95939220
63TRPM70.95002113
64SYK0.94481762
65ACVR1B0.88868913
66SIK10.88750788
67RIPK10.88220956
68EPHA30.86899643
69CSF1R0.86816575
70MET0.86306552
71LYN0.86153660
72NEK10.83481004
73MAP3K110.83382091
74LMTK20.81856280
75PDK20.80237023
76ITK0.79494505
77MAPK110.78136979
78MAP3K130.77803950
79LCK0.72290529
80MAP3K10.71414166
81YES10.69259849
82NLK0.68828829
83MARK30.68808757
84PIK3CG0.67254633
85TLK10.66345698
86MAP3K80.66320181
87BMPR20.66117715
88IRAK10.65826282
89FGFR30.65820421
90CDK40.64481369
91CDK60.63983280
92EIF2AK20.61739805
93CDK90.61435499
94STK40.61078444
95CLK10.61011711
96ADRBK20.60232438
97FES0.59218087
98MAP3K30.58419444
99CDC42BPA0.56177858
100MUSK0.56154153
101MAP3K50.52664531
102PRKCD0.52208076
103RPS6KB20.51750396
104MOS0.51667097
105STK390.50251716
106NUAK10.49406470
107PAK40.49095539
108MAP2K60.48769705
109MAPK40.47696496
110SCYL20.46808707
111TRIB30.46288355
112GRK10.45694056
113PDPK10.44939061
114ABL10.44514701
115MELK0.42704442
116EPHB10.42211732
117DAPK10.42143985
118SMG10.41395428
119WEE10.38648582
120HCK0.38439608
121MAPKAPK20.37744992
122WNK40.37403548
123PIK3CA0.37076916
124EGFR0.36276449
125EIF2AK30.35431555
126CDK70.35202799
127STK30.34187806
128MYLK0.34172178
129STK240.33129591
130PRKCQ0.32292490
131BRSK20.29851027
132RPS6KA60.27901505
133ERBB40.27654329

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.60208258
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82951620
3Autoimmune thyroid disease_Homo sapiens_hsa053202.60311725
4Staphylococcus aureus infection_Homo sapiens_hsa051502.46088494
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.46024307
6Caffeine metabolism_Homo sapiens_hsa002322.39289838
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23870569
8Arginine biosynthesis_Homo sapiens_hsa002202.21652313
9Leishmaniasis_Homo sapiens_hsa051401.96638540
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95078397
11Fat digestion and absorption_Homo sapiens_hsa049751.92580992
12Type I diabetes mellitus_Homo sapiens_hsa049401.84157974
13Tryptophan metabolism_Homo sapiens_hsa003801.83894843
14Complement and coagulation cascades_Homo sapiens_hsa046101.80433361
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75322967
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70891188
17Histidine metabolism_Homo sapiens_hsa003401.70879733
18Folate biosynthesis_Homo sapiens_hsa007901.68268877
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.63683626
20Sulfur metabolism_Homo sapiens_hsa009201.60421294
21* Legionellosis_Homo sapiens_hsa051341.59759492
22Starch and sucrose metabolism_Homo sapiens_hsa005001.56563533
23Fatty acid degradation_Homo sapiens_hsa000711.52382043
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49000145
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46047548
26Vitamin digestion and absorption_Homo sapiens_hsa049771.44192334
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41192627
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.36959621
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32788670
30Renin-angiotensin system_Homo sapiens_hsa046141.32092132
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30833109
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.30529544
33Graft-versus-host disease_Homo sapiens_hsa053321.30406188
34Chemical carcinogenesis_Homo sapiens_hsa052041.27769886
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26166204
36Peroxisome_Homo sapiens_hsa041461.25285496
37PPAR signaling pathway_Homo sapiens_hsa033201.24050273
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23484627
39beta-Alanine metabolism_Homo sapiens_hsa004101.21101626
40Galactose metabolism_Homo sapiens_hsa000521.20162482
41* Pertussis_Homo sapiens_hsa051331.19017288
42Measles_Homo sapiens_hsa051621.17105497
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12973431
44Retinol metabolism_Homo sapiens_hsa008301.11919916
45Osteoclast differentiation_Homo sapiens_hsa043801.11185961
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11011058
47Bile secretion_Homo sapiens_hsa049761.09490171
48Mineral absorption_Homo sapiens_hsa049781.08797461
49Influenza A_Homo sapiens_hsa051641.07582966
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.07170133
51ABC transporters_Homo sapiens_hsa020101.01772227
52* TNF signaling pathway_Homo sapiens_hsa046681.00575992
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99423038
54Selenocompound metabolism_Homo sapiens_hsa004500.99333893
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99255255
56Pentose phosphate pathway_Homo sapiens_hsa000300.99032081
57Sulfur relay system_Homo sapiens_hsa041220.98606770
58Herpes simplex infection_Homo sapiens_hsa051680.97884869
59Allograft rejection_Homo sapiens_hsa053300.93866277
60Lysosome_Homo sapiens_hsa041420.88809461
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88141439
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85446051
63Malaria_Homo sapiens_hsa051440.84792979
64African trypanosomiasis_Homo sapiens_hsa051430.83751632
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82302223
66Toxoplasmosis_Homo sapiens_hsa051450.81986460
67Glutathione metabolism_Homo sapiens_hsa004800.81127960
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79996736
69Tuberculosis_Homo sapiens_hsa051520.79784394
70Hematopoietic cell lineage_Homo sapiens_hsa046400.79462340
71Proteasome_Homo sapiens_hsa030500.78433567
72Phenylalanine metabolism_Homo sapiens_hsa003600.77961483
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75377201
74Linoleic acid metabolism_Homo sapiens_hsa005910.74573920
75Arachidonic acid metabolism_Homo sapiens_hsa005900.73865992
76Primary immunodeficiency_Homo sapiens_hsa053400.72379580
77DNA replication_Homo sapiens_hsa030300.71881733
78Salmonella infection_Homo sapiens_hsa051320.71150452
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70039673
80Antigen processing and presentation_Homo sapiens_hsa046120.69657718
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68861641
82* Apoptosis_Homo sapiens_hsa042100.64588820
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64133277
84Hepatitis C_Homo sapiens_hsa051600.64018257
85Chemokine signaling pathway_Homo sapiens_hsa040620.62858212
86B cell receptor signaling pathway_Homo sapiens_hsa046620.62628248
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.62326692
88Arginine and proline metabolism_Homo sapiens_hsa003300.60852399
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.60749402
90Carbon metabolism_Homo sapiens_hsa012000.60593006
91Prion diseases_Homo sapiens_hsa050200.58897052
92Sphingolipid metabolism_Homo sapiens_hsa006000.58674590
93Fructose and mannose metabolism_Homo sapiens_hsa000510.58580692
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58282659
95Fatty acid metabolism_Homo sapiens_hsa012120.58165421
96Shigellosis_Homo sapiens_hsa051310.57699987
97Protein digestion and absorption_Homo sapiens_hsa049740.57001246
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56292349
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53130598
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.53086283
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.52787782
102Phagosome_Homo sapiens_hsa041450.51384388
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50366343
104Asthma_Homo sapiens_hsa053100.50360668
105Hepatitis B_Homo sapiens_hsa051610.48565924
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.47727253
107Other glycan degradation_Homo sapiens_hsa005110.46888756
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.46216088
109Tyrosine metabolism_Homo sapiens_hsa003500.45593510
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44647265
111T cell receptor signaling pathway_Homo sapiens_hsa046600.44534600
112Bladder cancer_Homo sapiens_hsa052190.44463976
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44275537
114Glycerolipid metabolism_Homo sapiens_hsa005610.43302959
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42270440
116Amoebiasis_Homo sapiens_hsa051460.41701427
117Biosynthesis of amino acids_Homo sapiens_hsa012300.40644505
118One carbon pool by folate_Homo sapiens_hsa006700.39500004
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39342044
120Viral myocarditis_Homo sapiens_hsa054160.38463818
121Rheumatoid arthritis_Homo sapiens_hsa053230.37073227
122Propanoate metabolism_Homo sapiens_hsa006400.36963908
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36567774

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