CASP8AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.12643600
2mitotic metaphase plate congression (GO:0007080)4.97874500
3DNA double-strand break processing (GO:0000729)4.97846812
4nuclear pore organization (GO:0006999)4.94027341
5kinetochore organization (GO:0051383)4.93846169
6mitotic chromosome condensation (GO:0007076)4.76691961
7mitotic sister chromatid cohesion (GO:0007064)4.75817479
8metaphase plate congression (GO:0051310)4.64409048
9DNA replication checkpoint (GO:0000076)4.51232078
10protein localization to kinetochore (GO:0034501)4.47425372
11chromatin remodeling at centromere (GO:0031055)4.36731919
12CENP-A containing nucleosome assembly (GO:0034080)4.32122865
13DNA unwinding involved in DNA replication (GO:0006268)4.30842311
14kinetochore assembly (GO:0051382)4.30649309
15DNA replication initiation (GO:0006270)4.24658966
16meiotic chromosome segregation (GO:0045132)4.23461979
17establishment of chromosome localization (GO:0051303)4.15791541
18DNA strand elongation involved in DNA replication (GO:0006271)4.10379205
19attachment of spindle microtubules to kinetochore (GO:0008608)4.09570841
20DNA replication-independent nucleosome organization (GO:0034724)4.08428777
21DNA replication-independent nucleosome assembly (GO:0006336)4.08428777
22centriole replication (GO:0007099)4.03029163
23protein localization to chromosome, centromeric region (GO:0071459)4.01550110
24pore complex assembly (GO:0046931)4.00702764
25mitotic recombination (GO:0006312)3.96724067
26telomere maintenance via recombination (GO:0000722)3.92471733
27DNA strand elongation (GO:0022616)3.89284911
28telomere maintenance via semi-conservative replication (GO:0032201)3.87799258
29sister chromatid segregation (GO:0000819)3.87746705
30mitotic nuclear envelope disassembly (GO:0007077)3.87600938
31mitotic sister chromatid segregation (GO:0000070)3.85231503
32histone exchange (GO:0043486)3.80289082
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76659446
34regulation of centriole replication (GO:0046599)3.73159947
35regulation of sister chromatid cohesion (GO:0007063)3.72986790
36microtubule depolymerization (GO:0007019)3.72643187
37DNA replication-dependent nucleosome assembly (GO:0006335)3.71690780
38DNA replication-dependent nucleosome organization (GO:0034723)3.71690780
39regulation of spindle organization (GO:0090224)3.67526317
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66450132
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.63114964
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.63114964
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.63114964
44nuclear envelope disassembly (GO:0051081)3.61779463
45membrane disassembly (GO:0030397)3.61779463
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.61290418
47positive regulation of chromosome segregation (GO:0051984)3.60613556
48double-strand break repair via nonhomologous end joining (GO:0006303)3.59594435
49non-recombinational repair (GO:0000726)3.59594435
50monoubiquitinated protein deubiquitination (GO:0035520)3.55136967
51double-strand break repair via homologous recombination (GO:0000724)3.52560174
52spindle checkpoint (GO:0031577)3.51740789
53recombinational repair (GO:0000725)3.51231974
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50928403
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.50325147
56chromatin assembly or disassembly (GO:0006333)3.49609480
57chromosome segregation (GO:0007059)3.48915004
58synapsis (GO:0007129)3.47978064
59sister chromatid cohesion (GO:0007062)3.45026000
60regulation of centrosome cycle (GO:0046605)3.43607940
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.43421830
62ribosome assembly (GO:0042255)3.43164818
63mitotic spindle organization (GO:0007052)3.43057614
64otic vesicle formation (GO:0030916)3.42939931
65resolution of meiotic recombination intermediates (GO:0000712)3.40176491
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40022496
67protein K6-linked ubiquitination (GO:0085020)3.37610123
68ncRNA catabolic process (GO:0034661)3.37153493
69regulation of chromosome segregation (GO:0051983)3.35984518
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35911392
71mismatch repair (GO:0006298)3.35500119
72DNA-dependent DNA replication (GO:0006261)3.34438535
73telomere maintenance via telomere lengthening (GO:0010833)3.33880009
74DNA duplex unwinding (GO:0032508)3.32943878
75DNA geometric change (GO:0032392)3.32832651
76postreplication repair (GO:0006301)3.29829718
77regulation of histone H3-K9 methylation (GO:0051570)3.29685649
78ATP-dependent chromatin remodeling (GO:0043044)3.28477982
79DNA topological change (GO:0006265)3.27585834
80replication fork processing (GO:0031297)3.27447859
81spindle assembly checkpoint (GO:0071173)3.27237109
82negative regulation of histone methylation (GO:0031061)3.26190092
83regulation of RNA export from nucleus (GO:0046831)3.25960364
84regulation of mitotic spindle organization (GO:0060236)3.24793689
85translesion synthesis (GO:0019985)3.24644595
86microtubule anchoring (GO:0034453)3.23694749
87regulation of centrosome duplication (GO:0010824)3.23384827
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.22803377
89protein localization to chromosome (GO:0034502)3.22596504
90regulation of nuclear cell cycle DNA replication (GO:0033262)3.20742272
91centriole assembly (GO:0098534)3.20461995
92mitotic spindle checkpoint (GO:0071174)3.20384768
93regulation of sister chromatid segregation (GO:0033045)3.19445422
94regulation of mitotic sister chromatid separation (GO:0010965)3.19445422
95regulation of mitotic sister chromatid segregation (GO:0033047)3.19445422
96negative regulation of chromosome segregation (GO:0051985)3.18763078
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18409589
98negative regulation of sister chromatid segregation (GO:0033046)3.18409589
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.18409589
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18409589
101centrosome organization (GO:0051297)3.16076538
102V(D)J recombination (GO:0033151)3.15016548
103mitotic spindle assembly checkpoint (GO:0007094)3.14712103
104regulation of DNA endoreduplication (GO:0032875)3.14707575
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13725011
106regulation of cilium movement (GO:0003352)3.13540874
107DNA ligation (GO:0006266)3.12198467
108negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.09837640
109histone H2A acetylation (GO:0043968)3.08194085
110nucleobase biosynthetic process (GO:0046112)3.07636796
111maturation of 5.8S rRNA (GO:0000460)3.06922903
112telomere maintenance (GO:0000723)3.05976591
113DNA conformation change (GO:0071103)3.05850093
114DNA synthesis involved in DNA repair (GO:0000731)3.05665831
115microtubule organizing center organization (GO:0031023)3.05215921
116pre-miRNA processing (GO:0031054)3.04865279
117telomere organization (GO:0032200)3.03219658
118purine nucleobase biosynthetic process (GO:0009113)3.02429419
119somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01943975
120somatic hypermutation of immunoglobulin genes (GO:0016446)3.01943975
121regulation of mitotic spindle checkpoint (GO:1903504)3.00966017
122regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00966017
123dosage compensation (GO:0007549)3.00582716
124DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.00567389
125chromatin assembly (GO:0031497)3.00182252
126chromosome condensation (GO:0030261)3.00153696
127IMP biosynthetic process (GO:0006188)2.99581028
128DNA catabolic process, exonucleolytic (GO:0000738)2.98268509
129positive regulation of histone H3-K4 methylation (GO:0051571)2.95417093
130regulation of helicase activity (GO:0051095)2.93401818
131mitochondrial DNA replication (GO:0006264)2.93193580
132double-strand break repair (GO:0006302)2.93101289
133mitotic G2/M transition checkpoint (GO:0044818)2.88087336
134intra-S DNA damage checkpoint (GO:0031573)2.85691444
135microtubule polymerization or depolymerization (GO:0031109)2.84859703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.49979128
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.84373663
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.88783180
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.20660418
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.89604195
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.66930795
7AR_21909140_ChIP-Seq_LNCAP_Human2.66315025
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.64556512
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53147514
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51792711
11GBX2_23144817_ChIP-Seq_PC3_Human2.48051660
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.47769783
13IGF1R_20145208_ChIP-Seq_DFB_Human2.39968038
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.38302412
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31054834
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25503977
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22216580
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.21954158
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21042064
20ZNF274_21170338_ChIP-Seq_K562_Hela2.19941216
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18898036
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10869718
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07984631
24TAF15_26573619_Chip-Seq_HEK293_Human2.03079502
25* E2F7_22180533_ChIP-Seq_HELA_Human11.8944293
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.98831650
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98413890
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94651814
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92302406
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90288673
31VDR_23849224_ChIP-Seq_CD4+_Human1.87111092
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86247690
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85631453
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85623570
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84877563
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84339939
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84087235
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82333982
39ELK1_19687146_ChIP-ChIP_HELA_Human1.81804269
40VDR_22108803_ChIP-Seq_LS180_Human1.76566722
41P300_19829295_ChIP-Seq_ESCs_Human1.75269309
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74817862
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.67794537
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.67471230
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65607276
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.65417952
47XRN2_22483619_ChIP-Seq_HELA_Human1.62557108
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59652531
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58476629
50ER_23166858_ChIP-Seq_MCF-7_Human1.55978818
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55812255
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55712594
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54302257
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49562278
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48165582
56CIITA_25753668_ChIP-Seq_RAJI_Human1.46375999
57KDM5A_27292631_Chip-Seq_BREAST_Human1.43432008
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43366229
59* TTF2_22483619_ChIP-Seq_HELA_Human1.42183499
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41937992
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40974019
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40365316
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39061755
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38444118
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37070080
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36584150
67SMAD4_21799915_ChIP-Seq_A2780_Human1.35658223
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35481773
69MYC_22102868_ChIP-Seq_BL_Human1.32880873
70GABP_19822575_ChIP-Seq_HepG2_Human1.32738571
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32309472
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32143733
73DCP1A_22483619_ChIP-Seq_HELA_Human1.26473899
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26074245
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26074245
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25183603
77CBP_20019798_ChIP-Seq_JUKART_Human1.25183603
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23403455
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23189717
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22587613
81* STAT3_23295773_ChIP-Seq_U87_Human1.22354000
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21274543
83IRF1_19129219_ChIP-ChIP_H3396_Human1.17532761
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.16078463
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15719533
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15361172
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15205965
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14439184
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14232506
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14114947
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14056025
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13222705
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11598166
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.08042082
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07939464
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07576552
97TCF4_23295773_ChIP-Seq_U87_Human1.07479104
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06894334
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06804650
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06624006
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06490353
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06461855
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.04641270
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04540511
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04088263
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03883380
107BCAT_22108803_ChIP-Seq_LS180_Human1.03730181
108RUNX2_22187159_ChIP-Seq_PCA_Human1.03078327
109* MYC_18940864_ChIP-ChIP_HL60_Human1.02408738
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00069704
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00032638
112TCF4_22108803_ChIP-Seq_LS180_Human0.99911561
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99165123
114AR_21572438_ChIP-Seq_LNCaP_Human0.98570580
115SOX9_26525672_Chip-Seq_HEART_Mouse0.97315326
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96936037
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96907142
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.96900961
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96523313
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.96190845
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95963593
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95198790
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94993480
124RNF2_27304074_Chip-Seq_NSC_Mouse0.94330747
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.94224053
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94148901
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93590411
128EWS_26573619_Chip-Seq_HEK293_Human0.93546947
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93533814
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.92759733
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91191333
132TFEB_21752829_ChIP-Seq_HELA_Human0.90692834
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90049875
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.89287837
135P53_22387025_ChIP-Seq_ESCs_Mouse0.88657175
136AR_25329375_ChIP-Seq_VCAP_Human0.88302293
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88102584
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88087135
139* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84880471
140* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83779938
141FUS_26573619_Chip-Seq_HEK293_Human0.82353359
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79988540
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79876756
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79238753
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78704895
146* SPI1_23547873_ChIP-Seq_NB4_Human0.77708160
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77502675
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76351847
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73983515
150PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71453108
151MYB_26560356_Chip-Seq_TH1_Human0.71165094
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.70684668
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.69246896
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68955657
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67283774
156CHD1_26751641_Chip-Seq_LNCaP_Human0.66603373
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.66289757
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66250053
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65799139
160* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65246539
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64656328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.71735167
2MP0008057_abnormal_DNA_replication4.40052760
3MP0003693_abnormal_embryo_hatching4.39677827
4MP0003111_abnormal_nucleus_morphology3.96327268
5MP0003077_abnormal_cell_cycle3.82880287
6MP0004957_abnormal_blastocyst_morpholog3.50055700
7MP0008058_abnormal_DNA_repair3.26589427
8MP0008877_abnormal_DNA_methylation3.18387329
9MP0008007_abnormal_cellular_replicative2.87084937
10MP0003123_paternal_imprinting2.58327424
11MP0002396_abnormal_hematopoietic_system2.42806192
12MP0003121_genomic_imprinting2.31047097
13MP0008932_abnormal_embryonic_tissue2.27841091
14MP0000350_abnormal_cell_proliferation2.22061458
15MP0010307_abnormal_tumor_latency2.20576044
16MP0001730_embryonic_growth_arrest2.10798994
17MP0010352_gastrointestinal_tract_polyps1.94812501
18MP0003787_abnormal_imprinting1.82529616
19MP0001672_abnormal_embryogenesis/_devel1.75354651
20MP0005380_embryogenesis_phenotype1.75354651
21MP0003136_yellow_coat_color1.66507779
22MP0003890_abnormal_embryonic-extraembry1.66209480
23MP0001697_abnormal_embryo_size1.65913485
24MP0004808_abnormal_hematopoietic_stem1.62260594
25MP0003786_premature_aging1.57894766
26MP0003984_embryonic_growth_retardation1.57644481
27MP0002085_abnormal_embryonic_tissue1.57460819
28MP0005076_abnormal_cell_differentiation1.56003835
29MP0002088_abnormal_embryonic_growth/wei1.53614475
30MP0006072_abnormal_retinal_apoptosis1.53413204
31MP0002084_abnormal_developmental_patter1.52141549
32MP0000490_abnormal_crypts_of1.49667419
33MP0003937_abnormal_limbs/digits/tail_de1.45669832
34MP0002086_abnormal_extraembryonic_tissu1.41791458
35MP0003718_maternal_effect1.41649666
36MP0002210_abnormal_sex_determination1.38793107
37MP0002837_dystrophic_cardiac_calcinosis1.37861614
38MP0003763_abnormal_thymus_physiology1.37854125
39MP0006292_abnormal_olfactory_placode1.37152027
40MP0004197_abnormal_fetal_growth/weight/1.32889075
41MP0005174_abnormal_tail_pigmentation1.32733660
42MP0010030_abnormal_orbit_morphology1.30564291
43MP0002009_preneoplasia1.30498171
44MP0002080_prenatal_lethality1.30376878
45MP0001293_anophthalmia1.28220299
46MP0000313_abnormal_cell_death1.27482139
47MP0002019_abnormal_tumor_incidence1.27297026
48MP0005187_abnormal_penis_morphology1.24179057
49MP0008995_early_reproductive_senescence1.22431745
50MP0003567_abnormal_fetal_cardiomyocyte1.22298159
51MP0001188_hyperpigmentation1.22257919
52MP0000631_abnormal_neuroendocrine_gland1.18439110
53MP0001929_abnormal_gametogenesis1.16018615
54MP0009697_abnormal_copulation1.14183173
55MP0001119_abnormal_female_reproductive1.13140713
56MP0001145_abnormal_male_reproductive1.12941750
57MP0006035_abnormal_mitochondrial_morpho1.12866246
58MP0004264_abnormal_extraembryonic_tissu1.12558258
59MP0000703_abnormal_thymus_morphology1.10814262
60MP0000653_abnormal_sex_gland1.10538915
61MP0000778_abnormal_nervous_system1.08639563
62MP0000569_abnormal_digit_pigmentation1.06138529
63MP0008789_abnormal_olfactory_epithelium1.04221178
64MP0003315_abnormal_perineum_morphology1.03665851
65MP0003698_abnormal_male_reproductive1.03084403
66MP0000427_abnormal_hair_cycle1.01780541
67MP0002006_tumorigenesis1.00562463
68MP0003941_abnormal_skin_development1.00389008
69MP0002398_abnormal_bone_marrow0.99975222
70MP0001984_abnormal_olfaction0.99453303
71MP0002751_abnormal_autonomic_nervous0.99357768
72MP0005394_taste/olfaction_phenotype0.98021555
73MP0005499_abnormal_olfactory_system0.98021555
74MP0001529_abnormal_vocalization0.97893702
75MP0005248_abnormal_Harderian_gland0.96506013
76MP0004084_abnormal_cardiac_muscle0.96318731
77MP0001545_abnormal_hematopoietic_system0.94951535
78MP0005397_hematopoietic_system_phenotyp0.94951535
79MP0009703_decreased_birth_body0.93489252
80MP0000015_abnormal_ear_pigmentation0.93469467
81MP0009250_abnormal_appendicular_skeleto0.92144357
82MP0009672_abnormal_birth_weight0.91964670
83MP0005253_abnormal_eye_physiology0.91779066
84MP0009333_abnormal_splenocyte_physiolog0.90806979
85MP0000432_abnormal_head_morphology0.90480221
86MP0002938_white_spotting0.89974294
87MP0000566_synostosis0.89619290
88MP0009053_abnormal_anal_canal0.88879451
89MP0002102_abnormal_ear_morphology0.88050331
90MP0003755_abnormal_palate_morphology0.87924115
91MP0003935_abnormal_craniofacial_develop0.86296158
92MP0003861_abnormal_nervous_system0.84985071
93MP0001286_abnormal_eye_development0.84906375
94MP0002166_altered_tumor_susceptibility0.83229490
95MP0001764_abnormal_homeostasis0.82713766
96MP0002249_abnormal_larynx_morphology0.82257327
97MP0002722_abnormal_immune_system0.81674736
98MP0003385_abnormal_body_wall0.81542353
99MP0001915_intracranial_hemorrhage0.79899670
100MP0005408_hypopigmentation0.79276372
101MP0005391_vision/eye_phenotype0.79261834
102MP0005266_abnormal_metabolism0.79092219
103MP0000537_abnormal_urethra_morphology0.77058309
104MP0010386_abnormal_urinary_bladder0.76826407
105MP0005551_abnormal_eye_electrophysiolog0.76688860
106MP0002160_abnormal_reproductive_system0.76458550
107MP0002697_abnormal_eye_size0.76024537
108MP0002736_abnormal_nociception_after0.75760889
109MP0000689_abnormal_spleen_morphology0.75729107
110MP0000428_abnormal_craniofacial_morphol0.75491639
111MP0002095_abnormal_skin_pigmentation0.72136141
112MP0002092_abnormal_eye_morphology0.71629530
113MP0000647_abnormal_sebaceous_gland0.70682324
114MP0000049_abnormal_middle_ear0.70558275
115MP0005389_reproductive_system_phenotype0.69236259
116MP0002163_abnormal_gland_morphology0.68349735
117MP0003880_abnormal_central_pattern0.68290567
118MP0005621_abnormal_cell_physiology0.67669120
119MP0002877_abnormal_melanocyte_morpholog0.67563176
120MP0005646_abnormal_pituitary_gland0.67094296
121MP0003699_abnormal_female_reproductive0.67072910
122MP0002161_abnormal_fertility/fecundity0.66872238
123MP0008770_decreased_survivor_rate0.66745020
124MP0001485_abnormal_pinna_reflex0.65914318
125MP0005384_cellular_phenotype0.65385301
126MP0006054_spinal_hemorrhage0.64753866
127MP0002429_abnormal_blood_cell0.64250660
128MP0006276_abnormal_autonomic_nervous0.63912933
129MP0002638_abnormal_pupillary_reflex0.63748133
130MP0002075_abnormal_coat/hair_pigmentati0.63563322
131MP0002925_abnormal_cardiovascular_devel0.63176221
132MP0002111_abnormal_tail_morphology0.62336966
133MP0003119_abnormal_digestive_system0.62136992
134MP0003943_abnormal_hepatobiliary_system0.61290999
135MP0005367_renal/urinary_system_phenotyp0.60898942
136MP0000516_abnormal_urinary_system0.60898942
137MP0000716_abnormal_immune_system0.60718526
138MP0002233_abnormal_nose_morphology0.59475322
139MP0001346_abnormal_lacrimal_gland0.58598962
140MP0000627_abnormal_mammary_gland0.58445257
141MP0002114_abnormal_axial_skeleton0.58403180
142MP0005451_abnormal_body_composition0.58361528

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.24617352
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.79580951
3Birth length less than 3rd percentile (HP:0003561)4.76409466
4Abnormality of chromosome stability (HP:0003220)4.08906013
5Volvulus (HP:0002580)3.90039996
6Ectopic kidney (HP:0000086)3.48259232
7Meckel diverticulum (HP:0002245)3.44057340
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.37722174
9Abnormality of the preputium (HP:0100587)3.29719211
10Patellar aplasia (HP:0006443)3.24900150
11Abnormality of the ileum (HP:0001549)3.22870341
12Breast hypoplasia (HP:0003187)3.07630600
13Aplasia/Hypoplasia of the patella (HP:0006498)3.02166574
14Medulloblastoma (HP:0002885)3.00873472
15Abnormality of the labia minora (HP:0012880)2.97237674
16Facial hemangioma (HP:0000329)2.91506196
17Myelodysplasia (HP:0002863)2.89025045
18Abnormality of the fingertips (HP:0001211)2.88435724
19Short 4th metacarpal (HP:0010044)2.86872534
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86872534
21Small intestinal stenosis (HP:0012848)2.86563353
22Duodenal stenosis (HP:0100867)2.86563353
23Impulsivity (HP:0100710)2.75908433
24Colon cancer (HP:0003003)2.66274292
25Renal cortical cysts (HP:0000803)2.64981157
26Abnormality of midbrain morphology (HP:0002418)2.63065481
27Molar tooth sign on MRI (HP:0002419)2.63065481
28Papillary thyroid carcinoma (HP:0002895)2.57704738
29Pancreatic cysts (HP:0001737)2.57381760
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.56483254
31Acute myeloid leukemia (HP:0004808)2.56150517
32Increased nuchal translucency (HP:0010880)2.53666673
33Nephroblastoma (Wilms tumor) (HP:0002667)2.53151241
34Sloping forehead (HP:0000340)2.52779214
35Abnormality of the carotid arteries (HP:0005344)2.52668054
36Pancreatic fibrosis (HP:0100732)2.41511156
37Esophageal atresia (HP:0002032)2.39021335
38Clubbing of toes (HP:0100760)2.38815291
39Abnormal lung lobation (HP:0002101)2.38213133
40Embryonal renal neoplasm (HP:0011794)2.36199080
41Oligodactyly (HP:0012165)2.35265949
42Absent radius (HP:0003974)2.32624793
43Abnormality of the duodenum (HP:0002246)2.31637227
44Deviation of the thumb (HP:0009603)2.30094569
45Oligodactyly (hands) (HP:0001180)2.27345259
46True hermaphroditism (HP:0010459)2.27309169
47Reduced antithrombin III activity (HP:0001976)2.26919736
48Proximal placement of thumb (HP:0009623)2.25701634
49Gastrointestinal atresia (HP:0002589)2.25326456
50Type II lissencephaly (HP:0007260)2.24582692
51Long eyelashes (HP:0000527)2.23269307
52Selective tooth agenesis (HP:0001592)2.20813057
53Rhabdomyosarcoma (HP:0002859)2.20775783
54Atresia of the external auditory canal (HP:0000413)2.20160251
55Intestinal atresia (HP:0011100)2.20052658
56Ependymoma (HP:0002888)2.19492105
57Short thumb (HP:0009778)2.19388320
58Capillary hemangiomas (HP:0005306)2.18904000
59Prominent nose (HP:0000448)2.17279423
60Aplasia involving forearm bones (HP:0009822)2.16406085
61Absent forearm bone (HP:0003953)2.16406085
62Supernumerary spleens (HP:0009799)2.15111518
6311 pairs of ribs (HP:0000878)2.14899261
64Bone marrow hypocellularity (HP:0005528)2.12461794
65Neoplasm of the oral cavity (HP:0100649)2.12241313
66Nephronophthisis (HP:0000090)2.11547695
67Agnosia (HP:0010524)2.11517714
68Cafe-au-lait spot (HP:0000957)2.11118118
69Absent thumb (HP:0009777)2.10373622
70Reticulocytopenia (HP:0001896)2.08509548
71Duplicated collecting system (HP:0000081)2.05609689
72Deep philtrum (HP:0002002)2.04054926
73Abnormality of the renal collecting system (HP:0004742)2.01868998
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.01563134
75Absent/shortened dynein arms (HP:0200106)2.01563134
76Microtia (HP:0008551)1.93768398
77Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93665405
78High anterior hairline (HP:0009890)1.91195269
79Tracheoesophageal fistula (HP:0002575)1.91008672
80Abnormality of the 4th metacarpal (HP:0010012)1.90711030
81Lip pit (HP:0100267)1.90680420
82Abnormal number of incisors (HP:0011064)1.90270858
83Retinal dysplasia (HP:0007973)1.89963812
84Poikiloderma (HP:0001029)1.88435622
85Triphalangeal thumb (HP:0001199)1.88416597
86Abnormality of the renal cortex (HP:0011035)1.87289593
87Aplastic anemia (HP:0001915)1.86806488
88Oral leukoplakia (HP:0002745)1.86093028
89Prostate neoplasm (HP:0100787)1.85530477
90Abnormality of chromosome segregation (HP:0002916)1.85236304
91Shawl scrotum (HP:0000049)1.83147935
92Urethral obstruction (HP:0000796)1.80336210
93Biliary tract neoplasm (HP:0100574)1.80230157
94Sandal gap (HP:0001852)1.79738666
95Astigmatism (HP:0000483)1.79716597
96Abnormality of the anterior horn cell (HP:0006802)1.78504943
97Degeneration of anterior horn cells (HP:0002398)1.78504943
98Premature graying of hair (HP:0002216)1.78434227
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.78418890
100Cerebellar dysplasia (HP:0007033)1.78025178
101Dandy-Walker malformation (HP:0001305)1.77998030
102Hepatoblastoma (HP:0002884)1.77893485
103Arteriovenous malformation (HP:0100026)1.76724269
104Bifid tongue (HP:0010297)1.76113974
105Glioma (HP:0009733)1.75708563
106Acute lymphatic leukemia (HP:0006721)1.73665070
107Thyroiditis (HP:0100646)1.73460131
108Trigonocephaly (HP:0000243)1.73376802
109Abnormality of the renal medulla (HP:0100957)1.73340358
110Small hand (HP:0200055)1.73175389
111Neoplasm of the pancreas (HP:0002894)1.73109944
112Carpal bone hypoplasia (HP:0001498)1.71586573
113Chronic hepatic failure (HP:0100626)1.71547600
114Oligohydramnios (HP:0001562)1.71296925
115Long clavicles (HP:0000890)1.71134459
116High pitched voice (HP:0001620)1.70877436
117Preaxial hand polydactyly (HP:0001177)1.70576528
118Astrocytoma (HP:0009592)1.70247806
119Abnormality of the astrocytes (HP:0100707)1.70247806
120Short middle phalanx of the 5th finger (HP:0004220)1.69337090
121Truncal obesity (HP:0001956)1.68714783
122Inability to walk (HP:0002540)1.68687166
123Hypoplasia of the pons (HP:0012110)1.67790348
124Neoplasm of the adrenal cortex (HP:0100641)1.67443378
125Squamous cell carcinoma (HP:0002860)1.67330294
126Optic nerve hypoplasia (HP:0000609)1.66614273
127Neoplasm of the small intestine (HP:0100833)1.66560885
128Amaurosis fugax (HP:0100576)1.66435318
129Gonadotropin excess (HP:0000837)1.66374164
130Lissencephaly (HP:0001339)1.66187915
131Cellular immunodeficiency (HP:0005374)1.66027295
132Missing ribs (HP:0000921)1.65285599
133Poor coordination (HP:0002370)1.64952714
134Lymphoma (HP:0002665)1.64179954
135Horseshoe kidney (HP:0000085)1.63781728
136Hypoplastic labia majora (HP:0000059)1.63316878
137Abnormality of DNA repair (HP:0003254)1.63248181
138Basal cell carcinoma (HP:0002671)1.63059240
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.62901680
140Abnormal biliary tract morphology (HP:0012440)1.62514107
141Stenosis of the external auditory canal (HP:0000402)1.62241731
142Abnormality of cochlea (HP:0000375)1.61936332
143Slender long bone (HP:0003100)1.61770722
144Optic nerve coloboma (HP:0000588)1.61424685
145Abnormality of the incisor (HP:0000676)1.61181003
146Combined immunodeficiency (HP:0005387)1.60850574
147Septo-optic dysplasia (HP:0100842)1.60192613
148Protruding tongue (HP:0010808)1.59786392
149Choanal atresia (HP:0000453)1.59131033
150Aqueductal stenosis (HP:0002410)1.58316431
151Anencephaly (HP:0002323)1.58305766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.81747105
2WEE13.21390765
3LATS13.18752904
4PLK43.14208807
5SRPK13.08426134
6NEK22.86169163
7BRSK22.69828608
8BUB12.66589424
9TTK2.65640705
10CDK122.61278262
11ACVR1B2.28197453
12STK38L2.26795358
13MKNK12.08489844
14STK32.07821746
15PLK32.07393754
16PLK12.04531966
17ATR2.03430909
18CHEK21.95428746
19EIF2AK11.89790228
20AURKB1.87781363
21TRIM281.86570780
22WNK31.81293923
23PINK11.72925717
24MKNK21.71369545
25PASK1.66078315
26MAPK131.60100519
27VRK11.59210742
28CHEK11.59069849
29CDK71.57169278
30ATM1.49571852
31BMPR1B1.45142034
32CASK1.37617533
33RPS6KA41.32194183
34MAP3K41.30752267
35STK41.30008351
36BRSK11.29959682
37CDK41.29475793
38LATS21.28065638
39NUAK11.25956084
40DYRK31.21226978
41ZAK1.19610356
42STK101.19583686
43MELK1.19328646
44NEK11.18900607
45TNIK1.14751429
46TSSK61.14378864
47BRD41.13510763
48EIF2AK31.12481603
49RPS6KB21.11197243
50CDK81.10013174
51MAP4K21.09740789
52MAP3K81.09605742
53MAP3K61.06998446
54MAP2K71.05620712
55CDK21.05084589
56TLK11.02286741
57CDK61.02135720
58PBK1.01331877
59PIM10.98926842
60TAF10.95990387
61TGFBR10.91302410
62CDK10.90650982
63MST40.88424614
64CLK10.86617600
65CSNK1G20.86381736
66CAMK1G0.84816282
67CCNB10.84733271
68CDK90.84563878
69OBSCN0.80051001
70CAMK1D0.72288195
71AURKA0.70855283
72EIF2AK20.70483448
73FGFR20.70332303
74EEF2K0.67135898
75BCR0.60791452
76ERBB30.59517297
77MAP3K100.56060222
78TAOK30.56023196
79TEC0.55542431
80JAK30.54652828
81RPS6KA50.53045215
82INSRR0.52555503
83BRAF0.52368131
84UHMK10.52342847
85MAPK140.51580898
86CSNK2A20.51452656
87CSNK2A10.51025629
88PRKDC0.50516846
89ALK0.50205010
90CHUK0.49932846
91MINK10.49002064
92YES10.48491084
93PNCK0.48076037
94STK240.46502682
95FRK0.46482340
96CSNK1D0.46164318
97SCYL20.44550842
98TXK0.43980817
99PAK40.43804707
100RAF10.43621726
101MAP4K10.42837495
102NEK90.42423999
103NME10.42000816
104ERBB40.41882318
105AKT10.40455536
106FGFR30.40025032
107MTOR0.38628450
108PAK30.38528305
109PRKACB0.37559970
110GRK10.36859474
111CSNK1E0.36615080
112GSK3B0.35509943
113MAPKAPK50.34901485
114MARK30.34302507
115CSNK1G10.32870611
116TRPM70.32399133
117PIK3CG0.31470151
118STK390.31390627
119CDK30.31023842
120CAMK40.30699508
121DYRK20.29690596
122CSNK1A1L0.29579340
123NLK0.29301710
124CSNK1A10.29114676
125TESK20.28157781
126MAPK10.27826499
127RPS6KB10.26709173
128MAPK100.25886830
129PLK20.24983379
130CSNK1G30.19310503

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57652791
2Mismatch repair_Homo sapiens_hsa034304.19513064
3Homologous recombination_Homo sapiens_hsa034403.52094918
4Cell cycle_Homo sapiens_hsa041103.45026424
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34280954
6Fanconi anemia pathway_Homo sapiens_hsa034603.06090744
7Non-homologous end-joining_Homo sapiens_hsa034503.05046910
8RNA transport_Homo sapiens_hsa030132.90343082
9Spliceosome_Homo sapiens_hsa030402.83894851
10Base excision repair_Homo sapiens_hsa034102.83163321
11RNA polymerase_Homo sapiens_hsa030202.70485745
12Nucleotide excision repair_Homo sapiens_hsa034202.64350424
13Basal transcription factors_Homo sapiens_hsa030222.43937074
14RNA degradation_Homo sapiens_hsa030182.37365912
15One carbon pool by folate_Homo sapiens_hsa006702.08136619
16mRNA surveillance pathway_Homo sapiens_hsa030152.06968984
17p53 signaling pathway_Homo sapiens_hsa041151.92500004
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87786086
19Pyrimidine metabolism_Homo sapiens_hsa002401.82551694
20Propanoate metabolism_Homo sapiens_hsa006401.47114131
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43508743
22Systemic lupus erythematosus_Homo sapiens_hsa053221.41830183
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34593981
24Herpes simplex infection_Homo sapiens_hsa051681.33050060
25Proteasome_Homo sapiens_hsa030501.31025480
26Viral carcinogenesis_Homo sapiens_hsa052031.26662433
27MicroRNAs in cancer_Homo sapiens_hsa052061.26566925
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26280724
29Olfactory transduction_Homo sapiens_hsa047401.26064152
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21239900
31Ribosome_Homo sapiens_hsa030101.21210370
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20189445
33Oocyte meiosis_Homo sapiens_hsa041141.19410862
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16854601
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11110521
36Purine metabolism_Homo sapiens_hsa002301.07936572
37HTLV-I infection_Homo sapiens_hsa051661.02226095
38Small cell lung cancer_Homo sapiens_hsa052220.97946246
39Taste transduction_Homo sapiens_hsa047420.97158258
40Butanoate metabolism_Homo sapiens_hsa006500.95991529
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94893105
42TGF-beta signaling pathway_Homo sapiens_hsa043500.94820892
43Antigen processing and presentation_Homo sapiens_hsa046120.94660126
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94289971
45Phototransduction_Homo sapiens_hsa047440.92169144
46Thyroid cancer_Homo sapiens_hsa052160.84447956
47Colorectal cancer_Homo sapiens_hsa052100.84344207
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83775574
49Primary immunodeficiency_Homo sapiens_hsa053400.81051659
50Nitrogen metabolism_Homo sapiens_hsa009100.80590691
51Hepatitis B_Homo sapiens_hsa051610.79036754
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.78396575
53Pancreatic cancer_Homo sapiens_hsa052120.75315581
54Measles_Homo sapiens_hsa051620.74617942
55Regulation of autophagy_Homo sapiens_hsa041400.74250630
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.73892864
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73129409
58Adherens junction_Homo sapiens_hsa045200.71851726
59Nicotine addiction_Homo sapiens_hsa050330.67704291
60Hippo signaling pathway_Homo sapiens_hsa043900.67472988
61Prostate cancer_Homo sapiens_hsa052150.67173193
62Dorso-ventral axis formation_Homo sapiens_hsa043200.64121276
63Chronic myeloid leukemia_Homo sapiens_hsa052200.63903577
64Basal cell carcinoma_Homo sapiens_hsa052170.61405659
65Alcoholism_Homo sapiens_hsa050340.60035600
66Viral myocarditis_Homo sapiens_hsa054160.59551478
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58003013
68Lysine degradation_Homo sapiens_hsa003100.57931005
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54860964
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54397343
71Influenza A_Homo sapiens_hsa051640.53806912
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.53621025
73Pathways in cancer_Homo sapiens_hsa052000.51787310
74Apoptosis_Homo sapiens_hsa042100.50051966
75Notch signaling pathway_Homo sapiens_hsa043300.49001189
76Steroid biosynthesis_Homo sapiens_hsa001000.48693085
77Non-small cell lung cancer_Homo sapiens_hsa052230.48110041
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47810156
79Hematopoietic cell lineage_Homo sapiens_hsa046400.47557347
80FoxO signaling pathway_Homo sapiens_hsa040680.46682650
81Endometrial cancer_Homo sapiens_hsa052130.45469052
82Hedgehog signaling pathway_Homo sapiens_hsa043400.43675152
83Huntingtons disease_Homo sapiens_hsa050160.43261269
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.43206860
85mTOR signaling pathway_Homo sapiens_hsa041500.41109700
86Gap junction_Homo sapiens_hsa045400.40533949
87Wnt signaling pathway_Homo sapiens_hsa043100.39713873
88T cell receptor signaling pathway_Homo sapiens_hsa046600.39586188
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38465858
90Shigellosis_Homo sapiens_hsa051310.38123701
91Circadian entrainment_Homo sapiens_hsa047130.37865198
92Legionellosis_Homo sapiens_hsa051340.37079617
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35425319
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35352720
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35222766
96Pyruvate metabolism_Homo sapiens_hsa006200.33914024
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33645416
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33057632
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31854968
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31633431
101Parkinsons disease_Homo sapiens_hsa050120.31538954
102Vitamin B6 metabolism_Homo sapiens_hsa007500.31413576
103Melanoma_Homo sapiens_hsa052180.30929623
104Selenocompound metabolism_Homo sapiens_hsa004500.30869400
105Glutamatergic synapse_Homo sapiens_hsa047240.30557128
106Protein export_Homo sapiens_hsa030600.30403363
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29788117
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29313264
109Pentose phosphate pathway_Homo sapiens_hsa000300.28978137
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28815089
111Proteoglycans in cancer_Homo sapiens_hsa052050.28298380
112Toxoplasmosis_Homo sapiens_hsa051450.28160507
113Prolactin signaling pathway_Homo sapiens_hsa049170.27789238
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27145730
115Salivary secretion_Homo sapiens_hsa049700.26671713
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26162794
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.26098910
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26074481
119Melanogenesis_Homo sapiens_hsa049160.25907984
120Leishmaniasis_Homo sapiens_hsa051400.25400389
121B cell receptor signaling pathway_Homo sapiens_hsa046620.25356267
122Autoimmune thyroid disease_Homo sapiens_hsa053200.25137471
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24746685
124HIF-1 signaling pathway_Homo sapiens_hsa040660.23890497
125Retinol metabolism_Homo sapiens_hsa008300.23621923
126Metabolic pathways_Homo sapiens_hsa011000.23571082
127Acute myeloid leukemia_Homo sapiens_hsa052210.23291712
128Circadian rhythm_Homo sapiens_hsa047100.23128893
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22385024
130Long-term depression_Homo sapiens_hsa047300.22334034
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22241156
132Amphetamine addiction_Homo sapiens_hsa050310.21890399
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.21682937
134Renin secretion_Homo sapiens_hsa049240.21421463
135Allograft rejection_Homo sapiens_hsa053300.21160387
136Renal cell carcinoma_Homo sapiens_hsa052110.19992476
137TNF signaling pathway_Homo sapiens_hsa046680.19726983
138Oxytocin signaling pathway_Homo sapiens_hsa049210.19709878
139Dopaminergic synapse_Homo sapiens_hsa047280.19275892
140Folate biosynthesis_Homo sapiens_hsa007900.18686056
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18325018
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17967641
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17354517
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17234899
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14747164
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.14471995
147Glutathione metabolism_Homo sapiens_hsa004800.13884308
148Fatty acid metabolism_Homo sapiens_hsa012120.13352731
149Axon guidance_Homo sapiens_hsa043600.12766555

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