CASR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.16827251
2Golgi transport vesicle coating (GO:0048200)9.16827251
3endocrine pancreas development (GO:0031018)6.91067468
4positive regulation of glycogen biosynthetic process (GO:0045725)6.83228131
5negative regulation of gluconeogenesis (GO:0045721)6.31891626
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.09863099
7peptide hormone processing (GO:0016486)5.94900573
8positive regulation of glycogen metabolic process (GO:0070875)5.91442264
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.70994295
10type B pancreatic cell development (GO:0003323)5.68036755
11protein maturation by protein folding (GO:0022417)5.59461777
12COPII vesicle coating (GO:0048208)5.56017478
13glandular epithelial cell differentiation (GO:0002067)5.41566041
14fatty acid homeostasis (GO:0055089)5.36585911
15negative regulation of protein oligomerization (GO:0032460)5.35380005
16glandular epithelial cell development (GO:0002068)5.28150283
17protein retention in ER lumen (GO:0006621)5.26413457
18negative regulation of hormone biosynthetic process (GO:0032353)5.16623073
19positive regulation of respiratory burst (GO:0060267)5.09316494
20insulin secretion (GO:0030073)5.07605375
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.05486583
22negative regulation of acute inflammatory response (GO:0002674)4.98913757
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.92993631
24regulation of type B pancreatic cell apoptotic process (GO:2000674)4.86191610
25regulation of glucokinase activity (GO:0033131)4.68259694
26regulation of hexokinase activity (GO:1903299)4.68259694
27positive regulation of nuclease activity (GO:0032075)4.66019321
28negative regulation of hormone metabolic process (GO:0032351)4.61065883
29exocrine pancreas development (GO:0031017)4.50761445
30L-alpha-amino acid transmembrane transport (GO:1902475)4.46176138
31* positive regulation of insulin secretion (GO:0032024)4.38547763
32negative regulation of glycogen metabolic process (GO:0070874)4.37991848
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36918122
34ER overload response (GO:0006983)4.33338675
35toxin metabolic process (GO:0009404)4.27724603
36columnar/cuboidal epithelial cell development (GO:0002066)4.27662927
37regulation of nuclease activity (GO:0032069)4.26928367
38sequestering of metal ion (GO:0051238)4.24645872
39response to lead ion (GO:0010288)4.20252776
40positive regulation of macroautophagy (GO:0016239)4.20077864
41vesicle coating (GO:0006901)4.17596754
42nucleoside diphosphate catabolic process (GO:0009134)4.12098379
43* regulation of insulin secretion (GO:0050796)4.05489585
44endoplasmic reticulum unfolded protein response (GO:0030968)4.03272500
45signal peptide processing (GO:0006465)3.98376309
46cellular response to unfolded protein (GO:0034620)3.96346063
47positive regulation of insulin receptor signaling pathway (GO:0046628)3.92483815
48drug transmembrane transport (GO:0006855)3.90846663
49peptide hormone secretion (GO:0030072)3.88600624
50positive regulation of glucose metabolic process (GO:0010907)3.85843485
51regulation of Golgi to plasma membrane protein transport (GO:0042996)3.83891112
52lactate metabolic process (GO:0006089)3.81264066
53peptide secretion (GO:0002790)3.81064662
54cellular response to topologically incorrect protein (GO:0035967)3.80771674
55ER-nucleus signaling pathway (GO:0006984)3.79509676
56nitric oxide mediated signal transduction (GO:0007263)3.79238977
57positive regulation of cellular response to insulin stimulus (GO:1900078)3.75424681
58regulation of glycogen biosynthetic process (GO:0005979)3.69192795
59regulation of glucan biosynthetic process (GO:0010962)3.69192795
60* regulation of peptide hormone secretion (GO:0090276)3.66617980
61positive regulation of response to nutrient levels (GO:0032109)3.65054079
62positive regulation of response to extracellular stimulus (GO:0032106)3.65054079
63ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.62425892
64regulation of glycolytic process (GO:0006110)3.60511612
65* regulation of peptide secretion (GO:0002791)3.59634683
66regulation of glucocorticoid metabolic process (GO:0031943)3.55720878
67epithelial cell fate commitment (GO:0072148)3.55572512
68macroautophagy (GO:0016236)3.53273160
69* positive regulation of peptide hormone secretion (GO:0090277)3.50855026
70positive regulation of Rap GTPase activity (GO:0032854)3.48644265
71positive regulation of nitric-oxide synthase activity (GO:0051000)3.48448682
72cellular potassium ion homeostasis (GO:0030007)3.47307875
73regulation of protein glycosylation (GO:0060049)3.43780843
74negative regulation of neurological system process (GO:0031645)3.43485318
75positive regulation of protein autophosphorylation (GO:0031954)3.42938331
76* positive regulation of peptide secretion (GO:0002793)3.36848723
77intra-Golgi vesicle-mediated transport (GO:0006891)3.33501126
78response to endoplasmic reticulum stress (GO:0034976)3.31857935
79embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29541240
80inner ear receptor cell development (GO:0060119)3.29314848
81negative regulation of norepinephrine secretion (GO:0010700)3.29278567
82trivalent inorganic anion homeostasis (GO:0072506)3.29168711
83phosphate ion homeostasis (GO:0055062)3.29168711
84tricarboxylic acid metabolic process (GO:0072350)3.27977130
85inositol phosphate catabolic process (GO:0071545)3.27619021
86negative regulation of insulin secretion (GO:0046676)3.26961648
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26928192
88regulation of energy homeostasis (GO:2000505)3.26722862
89positive regulation of cellular carbohydrate metabolic process (GO:0010676)3.25028439
90negative regulation of Ras GTPase activity (GO:0034261)3.23180389
91astrocyte differentiation (GO:0048708)3.21844704
92cellular response to glucagon stimulus (GO:0071377)3.21242796
934-hydroxyproline metabolic process (GO:0019471)3.18516312
94regulation of glycogen metabolic process (GO:0070873)3.18138394
95Golgi organization (GO:0007030)3.17183786
96positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.17122419
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16254973
98negative regulation of JUN kinase activity (GO:0043508)3.15917583
99* regulation of hormone secretion (GO:0046883)3.15284926
100protein N-linked glycosylation via asparagine (GO:0018279)3.13937422
101peptidyl-asparagine modification (GO:0018196)3.13024046
102peptide transport (GO:0015833)3.11000094
103phosphorylated carbohydrate dephosphorylation (GO:0046838)3.08833313
104inositol phosphate dephosphorylation (GO:0046855)3.08833313
105positive regulation of carbohydrate metabolic process (GO:0045913)3.08156617
106negative regulation of glycoprotein biosynthetic process (GO:0010561)3.06456410
107intestinal epithelial cell development (GO:0060576)3.05699461
108regulation of polysaccharide biosynthetic process (GO:0032885)3.02911421
109response to unfolded protein (GO:0006986)3.02104377
110protein localization to Golgi apparatus (GO:0034067)3.01627772
111negative regulation of catecholamine secretion (GO:0033604)3.01284346
112hormone secretion (GO:0046879)3.00565684
113protein targeting to Golgi (GO:0000042)3.00446304
114positive regulation of glycolytic process (GO:0045821)2.99419522
115regulation of glucocorticoid secretion (GO:2000849)2.96479368
116* regulation of peptide transport (GO:0090087)2.96016763
117regulation of steroid hormone biosynthetic process (GO:0090030)2.95239670
118positive regulation of glucose import (GO:0046326)2.93448639
119response to parathyroid hormone (GO:0071107)2.92573135
120protein N-linked glycosylation (GO:0006487)2.91555875
121ER to Golgi vesicle-mediated transport (GO:0006888)2.91020341
122hormone transport (GO:0009914)2.90772771
123response to topologically incorrect protein (GO:0035966)2.90371084
124membrane repolarization during action potential (GO:0086011)2.88632514
125cellular zinc ion homeostasis (GO:0006882)2.85932650
126regulation of cellular carbohydrate catabolic process (GO:0043471)2.85015408
127regulation of carbohydrate catabolic process (GO:0043470)2.85015408
128positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.83701469
129regulation of Rap GTPase activity (GO:0032317)2.82866705
130potassium ion homeostasis (GO:0055075)2.82828831
131negative regulation of peptide hormone secretion (GO:0090278)2.82527166
132cerebellar Purkinje cell layer development (GO:0021680)2.80737632
133positive regulation of growth hormone secretion (GO:0060124)2.80429586
134positive regulation of autophagy (GO:0010508)2.80149851
135phospholipid dephosphorylation (GO:0046839)2.79926525
136inositol phosphate-mediated signaling (GO:0048016)2.79873588
137negative regulation of digestive system process (GO:0060457)2.79774175
138* positive regulation of hormone secretion (GO:0046887)2.78939732
139positive regulation of DNA-templated transcription, initiation (GO:2000144)2.77780166
140positive regulation of vasodilation (GO:0045909)2.76624223
141negative regulation of peptide secretion (GO:0002792)2.74530315
142protein autoprocessing (GO:0016540)2.73022673
143regulation of calcium ion-dependent exocytosis (GO:0017158)2.72848670
144toxin transport (GO:1901998)2.72814554
145regulation of gluconeogenesis (GO:0006111)2.72571732
146* carbohydrate homeostasis (GO:0033500)2.72376795
147* glucose homeostasis (GO:0042593)2.72376795
148intestinal absorption (GO:0050892)2.72319879
149kidney morphogenesis (GO:0060993)2.72226306
150pancreas development (GO:0031016)2.71173866
151catecholamine biosynthetic process (GO:0042423)2.71056361
152catechol-containing compound biosynthetic process (GO:0009713)2.71056361
153* response to hexose (GO:0009746)2.70412077
154magnesium ion transport (GO:0015693)2.69217012
155regulation of polysaccharide metabolic process (GO:0032881)2.69028110
156* response to glucose (GO:0009749)2.68090349
157relaxation of cardiac muscle (GO:0055119)2.67058892
158mesenchymal cell differentiation involved in renal system development (GO:2001012)2.66119010
159mesenchymal cell differentiation involved in kidney development (GO:0072161)2.66119010
160cellular ketone body metabolic process (GO:0046950)2.65974469
161growth hormone secretion (GO:0030252)2.65836086
162phosphatidylinositol dephosphorylation (GO:0046856)2.65596271
163negative regulation of glycogen biosynthetic process (GO:0045719)2.64866060
164zinc ion homeostasis (GO:0055069)2.64836437
165amide transport (GO:0042886)2.64639256
166peptide catabolic process (GO:0043171)2.63342370
167myelin maintenance (GO:0043217)2.62899250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.14597708
2GATA1_22025678_ChIP-Seq_K562_Human3.12973775
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48740496
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.31372848
5VDR_22108803_ChIP-Seq_LS180_Human2.06500479
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98111646
7IGF1R_20145208_ChIP-Seq_DFB_Human1.96766420
8STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84153556
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82743491
10ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79407898
11HTT_18923047_ChIP-ChIP_STHdh_Human1.78505856
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74615448
13SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72397742
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.71594480
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.67314162
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.60952378
17NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60220886
18ZNF274_21170338_ChIP-Seq_K562_Hela1.59761544
19REST_21632747_ChIP-Seq_MESCs_Mouse1.59212672
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59132285
21GBX2_23144817_ChIP-Seq_PC3_Human1.54855493
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54028107
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53993789
24* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53255619
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47465769
26AR_25329375_ChIP-Seq_VCAP_Human1.47058052
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43629220
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42485899
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41462632
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40377358
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39138842
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.38637401
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37057873
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36452009
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35758910
36CDX2_22108803_ChIP-Seq_LS180_Human1.35679261
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35662271
38P300_19829295_ChIP-Seq_ESCs_Human1.33726671
39FUS_26573619_Chip-Seq_HEK293_Human1.31213896
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.29677409
41* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29146033
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28928330
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28449850
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.28302958
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.28174713
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27827256
47* STAT3_23295773_ChIP-Seq_U87_Human1.27788795
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27308933
49GATA1_19941826_ChIP-Seq_K562_Human1.26784382
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26466791
51LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24062812
52DROSHA_22980978_ChIP-Seq_HELA_Human1.23536529
53P53_22387025_ChIP-Seq_ESCs_Mouse1.22365018
54* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21076247
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.19351729
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19085012
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.18685560
58* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18533615
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18466968
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.18204467
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17756836
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17690464
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.16395860
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15837456
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.15741845
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.15337492
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.14811049
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14563705
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.14317600
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14235998
71FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13817610
72* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13813489
73ER_23166858_ChIP-Seq_MCF-7_Human1.12916622
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11267741
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.10626969
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10100668
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.09912851
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09118935
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.08396665
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08302843
81FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07539891
82CBP_21632823_ChIP-Seq_H3396_Human1.07077659
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.06905424
84* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06237401
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05877334
86* RXR_22158963_ChIP-Seq_LIVER_Mouse1.05731015
87P300_18555785_Chip-Seq_ESCs_Mouse1.05442795
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.05409786
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04563002
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04388156
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.04072340
92TCF4_22108803_ChIP-Seq_LS180_Human1.03933654
93* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03902611
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.03590637
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03433794
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03281311
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03194486
98TFEB_21752829_ChIP-Seq_HELA_Human1.02721297
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02613554
100REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02428093
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02140268
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01924448
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.01686738
104* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00747696
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.00501554
106AR_19668381_ChIP-Seq_PC3_Human1.00250486
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99611074
108SOX2_19829295_ChIP-Seq_ESCs_Human0.99012283
109NANOG_19829295_ChIP-Seq_ESCs_Human0.99012283
110NMYC_18555785_Chip-Seq_ESCs_Mouse0.97560934
111SMAD4_21799915_ChIP-Seq_A2780_Human0.97002634
112KLF4_18555785_Chip-Seq_ESCs_Mouse0.96935277
113AHR_22903824_ChIP-Seq_MCF-7_Human0.96604960
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96219690
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.95332829
116ZFX_18555785_Chip-Seq_ESCs_Mouse0.95236284
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95114837
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95014295
119RARB_27405468_Chip-Seq_BRAIN_Mouse0.92787370
120SOX2_20726797_ChIP-Seq_SW620_Human0.92786312
121TBL1_22424771_ChIP-Seq_293T_Human0.92075471
122* GF1B_26923725_Chip-Seq_HPCs_Mouse0.92070670
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91170201
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90096147
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89178081
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89062017
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88528360
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.88387574
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88259398
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87334881
131* TCF4_23295773_ChIP-Seq_U87_Human0.87255794
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87220154
133FOXH1_21741376_ChIP-Seq_ESCs_Human0.87107274
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.86701075
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86393113
136* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85701375
137* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85701375
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.85272740
139* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83809683
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83794060
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.83283956
142* GF1_26923725_Chip-Seq_HPCs_Mouse0.83247047
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83025529
144BCAT_22108803_ChIP-Seq_LS180_Human0.81923471
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.81846752
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.81776137
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81439263
148TP53_22573176_ChIP-Seq_HFKS_Human0.81186588
149TP63_23658742_ChIP-Seq_EP156T_Human0.81030999
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80542507
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.80278065
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79787380
153CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79472498
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79402098
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78992485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.51089337
2MP0003283_abnormal_digestive_organ5.25902385
3MP0002877_abnormal_melanocyte_morpholog4.48767219
4MP0002693_abnormal_pancreas_physiology4.06852352
5MP0003123_paternal_imprinting4.00044584
6MP0000013_abnormal_adipose_tissue3.92624477
7MP0002909_abnormal_adrenal_gland3.82113324
8MP0009780_abnormal_chondrocyte_physiolo3.77464472
9MP0001944_abnormal_pancreas_morphology3.67564363
10MP0010234_abnormal_vibrissa_follicle3.60390288
11MP0005379_endocrine/exocrine_gland_phen3.01366624
12MP0008877_abnormal_DNA_methylation2.90559648
13MP0003183_abnormal_peptide_metabolism2.89172031
14MP0010386_abnormal_urinary_bladder2.86279616
15MP0005220_abnormal_exocrine_pancreas2.52628778
16MP0002078_abnormal_glucose_homeostasis2.36933574
17MP0002837_dystrophic_cardiac_calcinosis2.27115211
18MP0002138_abnormal_hepatobiliary_system2.24880879
19MP0005645_abnormal_hypothalamus_physiol2.22881250
20* MP0001765_abnormal_ion_homeostasis2.15788871
21MP0006072_abnormal_retinal_apoptosis2.13176454
22MP0000003_abnormal_adipose_tissue2.11463502
23MP0004264_abnormal_extraembryonic_tissu2.10412956
24MP0003300_gastrointestinal_ulcer2.06789330
25* MP0000678_abnormal_parathyroid_gland1.98479826
26* MP0009643_abnormal_urine_homeostasis1.87572420
27MP0002938_white_spotting1.86961140
28MP0002928_abnormal_bile_duct1.86471894
29MP0003121_genomic_imprinting1.84893662
30MP0004510_myositis1.84271054
31MP0002234_abnormal_pharynx_morphology1.83131182
32MP0008961_abnormal_basal_metabolism1.79447513
33MP0003252_abnormal_bile_duct1.76603898
34MP0004270_analgesia1.73591261
35* MP0002896_abnormal_bone_mineralization1.72073793
36MP0003172_abnormal_lysosome_physiology1.71711154
37MP0001986_abnormal_taste_sensitivity1.69293458
38MP0001756_abnormal_urination1.67764570
39MP0000462_abnormal_digestive_system1.65376808
40* MP0003195_calcinosis1.63776969
41MP0003122_maternal_imprinting1.58100627
42MP0002822_catalepsy1.55628889
43MP0004145_abnormal_muscle_electrophysio1.53656487
44MP0005365_abnormal_bile_salt1.40007698
45MP0003045_fibrosis1.38894907
46MP0002876_abnormal_thyroid_physiology1.38414408
47* MP0003953_abnormal_hormone_level1.33783661
48MP0009046_muscle_twitch1.32405385
49MP0000613_abnormal_salivary_gland1.30008242
50MP0003959_abnormal_lean_body1.28485558
51MP0005646_abnormal_pituitary_gland1.27304332
52MP0002638_abnormal_pupillary_reflex1.27217127
53MP0008004_abnormal_stomach_pH1.26416752
54MP0005058_abnormal_lysosome_morphology1.24931466
55* MP0005636_abnormal_mineral_homeostasis1.23397522
56MP0005310_abnormal_salivary_gland1.18870982
57MP0005535_abnormal_body_temperature1.17432816
58MP0002090_abnormal_vision1.15778636
59MP0004019_abnormal_vitamin_homeostasis1.15089081
60MP0005375_adipose_tissue_phenotype1.09800717
61MP0000631_abnormal_neuroendocrine_gland1.09601645
62MP0001299_abnormal_eye_distance/1.09407358
63MP0002139_abnormal_hepatobiliary_system1.08665896
64MP0003868_abnormal_feces_composition1.07471782
65MP0005332_abnormal_amino_acid1.07411180
66MP0000230_abnormal_systemic_arterial1.06651764
67MP0010329_abnormal_lipoprotein_level1.06123036
68MP0003633_abnormal_nervous_system1.05979202
69MP0001270_distended_abdomen1.01718038
70MP0010352_gastrointestinal_tract_polyps1.01694179
71MP0000538_abnormal_urinary_bladder1.01621454
72MP0005257_abnormal_intraocular_pressure0.99962479
73MP0001984_abnormal_olfaction0.96104461
74MP0010678_abnormal_skin_adnexa0.94486297
75MP0002971_abnormal_brown_adipose0.94192037
76MP0001666_abnormal_nutrient_absorption0.90985145
77MP0003119_abnormal_digestive_system0.89849326
78MP0003011_delayed_dark_adaptation0.85613405
79MP0004036_abnormal_muscle_relaxation0.85607181
80MP0004885_abnormal_endolymph0.83324824
81MP0002277_abnormal_respiratory_mucosa0.82461646
82MP0002269_muscular_atrophy0.82461083
83MP0003879_abnormal_hair_cell0.82120700
84MP0009672_abnormal_birth_weight0.81714758
85MP0005670_abnormal_white_adipose0.78410659
86MP0001727_abnormal_embryo_implantation0.77082614
87MP0000569_abnormal_digit_pigmentation0.76261567
88MP0006036_abnormal_mitochondrial_physio0.76200576
89MP0004924_abnormal_behavior0.74408871
90MP0005386_behavior/neurological_phenoty0.74408871
91MP0001661_extended_life_span0.72567685
92MP0001346_abnormal_lacrimal_gland0.72119529
93MP0000427_abnormal_hair_cycle0.71946522
94MP0000747_muscle_weakness0.71889095
95MP0001485_abnormal_pinna_reflex0.70556635
96MP0005075_abnormal_melanosome_morpholog0.70521582
97MP0002272_abnormal_nervous_system0.69598649
98MP0001502_abnormal_circadian_rhythm0.69468386
99MP0003890_abnormal_embryonic-extraembry0.69129251
100MP0005253_abnormal_eye_physiology0.68355257
101MP0005551_abnormal_eye_electrophysiolog0.66787137
102MP0002734_abnormal_mechanical_nocicepti0.66424466
103MP0002572_abnormal_emotion/affect_behav0.66374089
104* MP0002168_other_aberrant_phenotype0.66320835
105MP0004215_abnormal_myocardial_fiber0.65974866
106MP0006276_abnormal_autonomic_nervous0.65492414
107MP0005084_abnormal_gallbladder_morpholo0.64885737
108MP0009703_decreased_birth_body0.64560040
109MP0006054_spinal_hemorrhage0.64485504
110MP0003787_abnormal_imprinting0.64415383
111MP0005448_abnormal_energy_balance0.63204093
112MP0002064_seizures0.63120461
113MP0003866_abnormal_defecation0.61844407
114MP0002118_abnormal_lipid_homeostasis0.61219359
115MP0009745_abnormal_behavioral_response0.60917708
116MP0004859_abnormal_synaptic_plasticity0.60528330
117MP0002295_abnormal_pulmonary_circulatio0.60353289
118MP0000639_abnormal_adrenal_gland0.59731999
119MP0002229_neurodegeneration0.59250500
120MP0005452_abnormal_adipose_tissue0.59218617
121MP0000681_abnormal_thyroid_gland0.58547726
122MP0003656_abnormal_erythrocyte_physiolo0.58413728
123* MP0002069_abnormal_eating/drinking_beha0.57967730
124MP0005334_abnormal_fat_pad0.56586447
125MP0002733_abnormal_thermal_nociception0.56262051
126MP0004134_abnormal_chest_morphology0.55917455
127MP0000955_abnormal_spinal_cord0.55917286
128MP0009840_abnormal_foam_cell0.55019098
129MP0004858_abnormal_nervous_system0.55012916
130MP0002557_abnormal_social/conspecific_i0.54912191
131MP0000516_abnormal_urinary_system0.54424808
132MP0005367_renal/urinary_system_phenotyp0.54424808
133* MP0009642_abnormal_blood_homeostasis0.53219561
134MP0003634_abnormal_glial_cell0.52684084
135MP0002160_abnormal_reproductive_system0.51114634
136* MP0002136_abnormal_kidney_physiology0.50902832
137MP0005187_abnormal_penis_morphology0.50535632
138* MP0001731_abnormal_postnatal_growth0.49084323
139MP0002163_abnormal_gland_morphology0.49016725

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.09473285
2* Hyperphosphatemia (HP:0002905)7.35255493
3* Tetany (HP:0001281)7.21072323
4Hypoglycemic seizures (HP:0002173)7.17392641
5Symptomatic seizures (HP:0011145)6.68986309
6Hypoglycemic coma (HP:0001325)6.36954173
7Ketoacidosis (HP:0001993)5.35664356
8Hyperglycemia (HP:0003074)5.29983177
9Pancreatic islet-cell hyperplasia (HP:0004510)5.27901044
10Insulin-resistant diabetes mellitus (HP:0000831)5.06553449
11Abnormality of endocrine pancreas physiology (HP:0012093)4.94756001
12Abnormality of the pancreatic islet cells (HP:0006476)4.94756001
13* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.75109325
14Large for gestational age (HP:0001520)4.59468176
15Late onset (HP:0003584)4.41140303
16Hyperactive renin-angiotensin system (HP:0000841)4.22156904
17Hypokalemic alkalosis (HP:0001949)4.16217288
18* Hypokalemia (HP:0002900)4.02173188
19* Abnormality of calcium-phosphate metabolism (HP:0100530)3.89838414
20Abnormality of chloride homeostasis (HP:0011422)3.83992404
21Generalized aminoaciduria (HP:0002909)3.80247638
22Decreased circulating renin level (HP:0003351)3.76131446
23Gout (HP:0001997)3.69751861
24Mucopolysacchariduria (HP:0008155)3.63358031
25Urinary glycosaminoglycan excretion (HP:0003541)3.63358031
26Osteomalacia (HP:0002749)3.62587494
27Abnormal pancreas size (HP:0012094)3.53101286
28Metabolic alkalosis (HP:0200114)3.52316733
29* Abnormality of potassium homeostasis (HP:0011042)3.43231671
30Abnormality of polysaccharide metabolism (HP:0011012)3.33020412
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33020412
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33020412
33Dysostosis multiplex (HP:0000943)3.19440118
34Alacrima (HP:0000522)3.19237135
35Hyperkalemia (HP:0002153)3.15723895
36* Abnormality of renin-angiotensin system (HP:0000847)3.15405055
37Agitation (HP:0000713)3.14821793
38Ketosis (HP:0001946)3.10775220
39Type I diabetes mellitus (HP:0100651)3.10101368
40Enlarged penis (HP:0000040)3.09779293
41Hyperaldosteronism (HP:0000859)3.01996131
42Unilateral renal agenesis (HP:0000122)2.98877961
43Conjugated hyperbilirubinemia (HP:0002908)2.96163662
44Insulin resistance (HP:0000855)2.93917462
45* Increased circulating renin level (HP:0000848)2.91574435
46Decreased lacrimation (HP:0000633)2.83623549
47Hypoparathyroidism (HP:0000829)2.83324539
48J-shaped sella turcica (HP:0002680)2.79443376
49Hyperthyroidism (HP:0000836)2.78849570
50Prominent metopic ridge (HP:0005487)2.74551796
51Retinal atrophy (HP:0001105)2.65500359
52Alkalosis (HP:0001948)2.55804571
53Adrenal overactivity (HP:0002717)2.55214672
54Abnormality of purine metabolism (HP:0004352)2.55067752
55Proximal tubulopathy (HP:0000114)2.53137375
56Abnormality of the intrinsic pathway (HP:0010989)2.48822170
57Abnormality of the metopic suture (HP:0005556)2.42425563
58* Hypocalcemia (HP:0002901)2.41960672
59Downturned corners of mouth (HP:0002714)2.39370547
60Hypsarrhythmia (HP:0002521)2.35878419
61Testicular neoplasm (HP:0010788)2.35597997
62Renal salt wasting (HP:0000127)2.35390164
63EEG with generalized epileptiform discharges (HP:0011198)2.33991916
64* Polyuria (HP:0000103)2.32687581
65Abnormality of urine glucose concentration (HP:0011016)2.26104030
66Glycosuria (HP:0003076)2.26104030
67Muscular hypotonia of the trunk (HP:0008936)2.23698116
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21530439
69Epileptiform EEG discharges (HP:0011182)2.21434107
70Neoplasm of the adrenal cortex (HP:0100641)2.20441138
71* Hypomagnesemia (HP:0002917)2.20433355
72Abdominal distention (HP:0003270)2.16436069
73Protuberant abdomen (HP:0001538)2.16102511
74Pheochromocytoma (HP:0002666)2.14377992
75* Abnormal urine output (HP:0012590)2.13236118
76Hepatoblastoma (HP:0002884)2.12279996
77Tongue fasciculations (HP:0001308)2.12262887
78* Hypophosphatemia (HP:0002148)2.10685933
79Papilledema (HP:0001085)2.09707909
80Hypokinesia (HP:0002375)2.08948589
81Increased purine levels (HP:0004368)2.08793348
82Hyperuricemia (HP:0002149)2.08793348
83Hypercortisolism (HP:0001578)2.08433213
84Fair hair (HP:0002286)2.03761746
85* Hyperparathyroidism (HP:0000843)2.01558613
86Exocrine pancreatic insufficiency (HP:0001738)2.01320499
87* Abnormality of renal excretion (HP:0011036)2.01058679
88Widely patent fontanelles and sutures (HP:0004492)2.00818528
89Vacuolated lymphocytes (HP:0001922)1.99640254
90Congenital glaucoma (HP:0001087)1.99373135
91Limb hypertonia (HP:0002509)1.98967043
92Metaphyseal dysplasia (HP:0100255)1.98410939
93Abnormal sex determination (HP:0012244)1.96343687
94Sex reversal (HP:0012245)1.96343687
95Enlarged kidneys (HP:0000105)1.94567440
96Dysautonomia (HP:0002459)1.93320130
97Ventricular fibrillation (HP:0001663)1.93156555
98Vascular calcification (HP:0004934)1.92494817
99Disproportionate short-trunk short stature (HP:0003521)1.88444526
100Abnormality of alkaline phosphatase activity (HP:0004379)1.88306847
101Intention tremor (HP:0002080)1.86508905
102Thickened calvaria (HP:0002684)1.84718455
103Delayed epiphyseal ossification (HP:0002663)1.83594625
104Hypothermia (HP:0002045)1.82522608
105Restlessness (HP:0000711)1.81698256
106Severe short stature (HP:0003510)1.81682023
107Elevated alkaline phosphatase (HP:0003155)1.80806019
108* Hypotension (HP:0002615)1.80641509
109Macroorchidism (HP:0000053)1.80455345
110Hamartoma of the eye (HP:0010568)1.79914922
111Abnormal enzyme/coenzyme activity (HP:0012379)1.79157067
112Muscle fibrillation (HP:0010546)1.76828963
113Germ cell neoplasia (HP:0100728)1.75155109
114Hyponatremia (HP:0002902)1.75003117
115Neuroendocrine neoplasm (HP:0100634)1.74602118
116Thin bony cortex (HP:0002753)1.74441963
117Thoracolumbar scoliosis (HP:0002944)1.73706402
118Abnormality of small intestinal villus morphology (HP:0011472)1.73698251
119Villous atrophy (HP:0011473)1.73698251
120* Abnormality of magnesium homeostasis (HP:0004921)1.73279180
121Increased density of long bones (HP:0006392)1.71138708
122Mixed hearing impairment (HP:0000410)1.70223613
123Hypoplastic labia majora (HP:0000059)1.69630487
124Skin nodule (HP:0200036)1.69428760
125* Hyperphosphaturia (HP:0003109)1.69377496
126Septate vagina (HP:0001153)1.68088543
127* Abnormal drinking behavior (HP:0030082)1.67492402
128* Polydipsia (HP:0001959)1.67492402
129Menstrual irregularities (HP:0000858)1.67244524
130Myoglobinuria (HP:0002913)1.65616296
131Progressive neurologic deterioration (HP:0002344)1.64664979
132Conjunctival hamartoma (HP:0100780)1.63634447
133Lower limb hyperreflexia (HP:0002395)1.62549690
134Calf muscle hypertrophy (HP:0008981)1.61584670
135Cardiovascular calcification (HP:0011915)1.60473063
136Small for gestational age (HP:0001518)1.58420454
137Generalized hypopigmentation of hair (HP:0011358)1.57424243
138Hepatic necrosis (HP:0002605)1.56767981
139Anxiety (HP:0000739)1.53661994
140Steatorrhea (HP:0002570)1.51141663
141Hematochezia (HP:0002573)1.51020988
142Diminished movement (HP:0002374)1.45870048
143Hemiparesis (HP:0001269)1.45333239
144Progressive hearing impairment (HP:0001730)1.44688857
145Acute hepatic failure (HP:0006554)1.43373569
146Microretrognathia (HP:0000308)1.41784240
147Neoplasm of the adrenal gland (HP:0100631)1.41412406
148Neonatal hypoglycemia (HP:0001998)1.39183157
149Muscle hypertrophy of the lower extremities (HP:0008968)1.36112509
150Abnormality of the labia minora (HP:0012880)1.34690000
151Adrenal hypoplasia (HP:0000835)1.34292769
152Hypogonadotrophic hypogonadism (HP:0000044)1.34032320
153Palpitations (HP:0001962)1.33182015
154Thyroid carcinoma (HP:0002890)1.31707935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.93631869
2WNK35.03991366
3WNK44.74446075
4MAPK154.47580834
5PASK3.98627390
6TAOK33.77230017
7FGFR23.66151277
8FRK2.80077227
9HIPK22.61571617
10MAP3K22.54115304
11PRKD32.51173810
12DAPK22.31570196
13PIK3CG2.29103191
14OXSR12.04090352
15UHMK12.02017702
16PINK11.99553496
17STK391.68093136
18TRPM71.64408271
19STK38L1.56614488
20WNK11.53861257
21STK31.53608881
22MAP3K11.51851183
23NTRK11.50745756
24ERN11.48699480
25PDK21.37092699
26IRAK11.35612194
27FLT31.32555702
28SCYL21.32051223
29PTK21.31688973
30EPHA31.29477162
31MAP2K61.26719604
32MST41.26332497
33IRAK31.25389936
34PAK31.20583382
35ACVR1B1.17190456
36DYRK1B1.13577559
37PDGFRA1.11869551
38MET1.11120454
39PRKCH1.10039391
40CAMKK21.08854174
41CDC42BPA1.05524811
42PRKD21.00756799
43MAP3K91.00185531
44NTRK30.98427867
45AKT30.96398353
46EPHB10.95726771
47PTK60.94555059
48MAP3K70.91574385
49CASK0.87361522
50MAP3K120.85697732
51STK240.83931589
52LATS10.81950123
53SGK4940.81873597
54SGK2230.81873597
55STK160.80892289
56LMTK20.79983117
57BMPR1B0.79899249
58STK110.78221002
59ADRBK20.75734996
60IRAK20.74783700
61PRKAA10.72462250
62TAOK10.71601809
63CSNK1G10.70918751
64EIF2AK30.66349489
65GRK10.66154052
66STK380.65603282
67MAP3K30.63445888
68PKN20.61083731
69BRSK20.61016154
70FER0.58477293
71GSK3A0.58472191
72MARK20.57733207
73EPHA20.56866794
74MAP3K40.56721215
75TRIB30.56495992
76JAK20.56361044
77SIK10.55915583
78ITK0.54500900
79SGK20.54458613
80CDK30.53995414
81FGFR40.53615885
82TNIK0.53294152
83PTK2B0.51075833
84BCR0.50336919
85MAP2K20.49110120
86CAMK2D0.48962800
87PRKCE0.48754965
88RET0.46443795
89STK40.46181578
90TESK10.45882332
91YES10.44744685
92SGK30.44354103
93PLK20.43715120
94TRIM280.43326762
95MTOR0.42834417
96MAP4K20.40873284
97NLK0.39773848
98NEK60.37372927
99KSR20.37325989
100PRKACG0.36238629
101DYRK1A0.36233426
102JAK10.35714781
103SGK10.35324103
104BRD40.34804872
105PDGFRB0.34803052
106BCKDK0.34059736
107PRKD10.33832588
108PRKACA0.33372946
109EIF2AK10.31799726
110CSNK1A10.31618931
111LIMK10.31292713
112PRKCI0.31238672
113NME10.31230686
114PRKCZ0.31141563
115CSNK1G20.30515930
116DAPK10.29478668
117CSNK1G30.29462287
118CAMK1G0.29272695
119PDK10.29225569
120OBSCN0.29123971
121CAMK1D0.28654321
122PRKAA20.28553125
123ADRBK10.28278456
124PRKG20.26945699
125CAMK2B0.26526583
126PRKG10.26515317
127IRAK40.26487453
128PAK60.26063621
129ALK0.25952832
130PLK30.25424719
131CSNK1E0.24695021
132IGF1R0.22849399
133ICK0.22764221
134PHKG20.22411919
135PHKG10.22411919
136CDK50.21666110
137ERBB30.21157277
138BMPR20.20723943
139FGFR30.20459520
140BRAF0.20161977
141PRKDC0.19944368
142RPS6KA20.18283328
143CHUK0.17448344
144NUAK10.17180528
145PNCK0.16871989
146RPS6KA30.16803837
147CDK120.15732878
148MAPK140.15236925

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.02270092
2Protein export_Homo sapiens_hsa030604.17426471
3Insulin secretion_Homo sapiens_hsa049113.37487019
4Sulfur metabolism_Homo sapiens_hsa009203.17685326
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.83950788
6Type II diabetes mellitus_Homo sapiens_hsa049302.58974227
7Type I diabetes mellitus_Homo sapiens_hsa049402.22776217
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96090778
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86060791
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.85784845
11Vibrio cholerae infection_Homo sapiens_hsa051101.76176774
12Butanoate metabolism_Homo sapiens_hsa006501.60837265
13Lysosome_Homo sapiens_hsa041421.52630930
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51095577
15Vitamin B6 metabolism_Homo sapiens_hsa007501.39175752
16Selenocompound metabolism_Homo sapiens_hsa004501.30542422
17N-Glycan biosynthesis_Homo sapiens_hsa005101.30335949
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27473875
19ABC transporters_Homo sapiens_hsa020101.24919748
20Tryptophan metabolism_Homo sapiens_hsa003801.24666277
21Cocaine addiction_Homo sapiens_hsa050301.23327217
22Pancreatic secretion_Homo sapiens_hsa049721.22752712
23Collecting duct acid secretion_Homo sapiens_hsa049661.18363309
24Other glycan degradation_Homo sapiens_hsa005111.17665967
25Thyroid hormone synthesis_Homo sapiens_hsa049181.13729397
26Glucagon signaling pathway_Homo sapiens_hsa049221.12458151
27Insulin resistance_Homo sapiens_hsa049311.08117486
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06846042
29Circadian rhythm_Homo sapiens_hsa047101.05776427
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02607806
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02123142
32Taste transduction_Homo sapiens_hsa047420.96033421
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89084248
34Salivary secretion_Homo sapiens_hsa049700.88693592
35Regulation of autophagy_Homo sapiens_hsa041400.86154117
36Amphetamine addiction_Homo sapiens_hsa050310.85873544
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84641260
38Protein digestion and absorption_Homo sapiens_hsa049740.82089651
39Starch and sucrose metabolism_Homo sapiens_hsa005000.81017258
40Folate biosynthesis_Homo sapiens_hsa007900.80215930
41Linoleic acid metabolism_Homo sapiens_hsa005910.76644932
42Sphingolipid metabolism_Homo sapiens_hsa006000.75925426
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71714687
44Serotonergic synapse_Homo sapiens_hsa047260.71337832
45Lysine degradation_Homo sapiens_hsa003100.70253134
46Cholinergic synapse_Homo sapiens_hsa047250.69549022
47Prolactin signaling pathway_Homo sapiens_hsa049170.69102483
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68904835
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.68187266
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.67987163
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67771248
52beta-Alanine metabolism_Homo sapiens_hsa004100.66967106
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66484875
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64444625
55Long-term depression_Homo sapiens_hsa047300.61896957
56Dopaminergic synapse_Homo sapiens_hsa047280.61274107
57GABAergic synapse_Homo sapiens_hsa047270.60042749
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58641216
59Circadian entrainment_Homo sapiens_hsa047130.57239442
60Synaptic vesicle cycle_Homo sapiens_hsa047210.56857577
61Dorso-ventral axis formation_Homo sapiens_hsa043200.56826807
62Estrogen signaling pathway_Homo sapiens_hsa049150.56145656
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55434585
64Inositol phosphate metabolism_Homo sapiens_hsa005620.54714451
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54450514
66Insulin signaling pathway_Homo sapiens_hsa049100.53975563
67Oxidative phosphorylation_Homo sapiens_hsa001900.53862130
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52462864
69Fatty acid degradation_Homo sapiens_hsa000710.52427224
70Prion diseases_Homo sapiens_hsa050200.49842933
71Fatty acid biosynthesis_Homo sapiens_hsa000610.48774879
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48571733
73Gastric acid secretion_Homo sapiens_hsa049710.48241733
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48177956
75Galactose metabolism_Homo sapiens_hsa000520.47586044
76Long-term potentiation_Homo sapiens_hsa047200.46043720
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45968698
78Ovarian steroidogenesis_Homo sapiens_hsa049130.44022972
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43662192
80Renin secretion_Homo sapiens_hsa049240.42806656
81cAMP signaling pathway_Homo sapiens_hsa040240.41494908
82Fat digestion and absorption_Homo sapiens_hsa049750.40871696
83Fatty acid elongation_Homo sapiens_hsa000620.40169870
84AMPK signaling pathway_Homo sapiens_hsa041520.39564081
85Bile secretion_Homo sapiens_hsa049760.39218942
86Phototransduction_Homo sapiens_hsa047440.39211369
87Arginine and proline metabolism_Homo sapiens_hsa003300.39124452
88Cardiac muscle contraction_Homo sapiens_hsa042600.38136327
89Phenylalanine metabolism_Homo sapiens_hsa003600.37679834
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37651745
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37629684
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36061169
93Ether lipid metabolism_Homo sapiens_hsa005650.36023456
94Histidine metabolism_Homo sapiens_hsa003400.35708417
95mTOR signaling pathway_Homo sapiens_hsa041500.35557615
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35011885
97Morphine addiction_Homo sapiens_hsa050320.34733619
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33682459
99Glutamatergic synapse_Homo sapiens_hsa047240.33112911
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32934102
101Retinol metabolism_Homo sapiens_hsa008300.31791073
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31740107
103Bladder cancer_Homo sapiens_hsa052190.31727470
104Peroxisome_Homo sapiens_hsa041460.30112844
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29090430
106Fatty acid metabolism_Homo sapiens_hsa012120.27622322
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27470443
108Nitrogen metabolism_Homo sapiens_hsa009100.27365435
109Mineral absorption_Homo sapiens_hsa049780.26486066
110Hedgehog signaling pathway_Homo sapiens_hsa043400.26448055
111Propanoate metabolism_Homo sapiens_hsa006400.26430766
112Prostate cancer_Homo sapiens_hsa052150.25852856
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.24413802
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22134333
115Metabolic pathways_Homo sapiens_hsa011000.21837892
116Alcoholism_Homo sapiens_hsa050340.21411308
117Melanogenesis_Homo sapiens_hsa049160.20872331
118FoxO signaling pathway_Homo sapiens_hsa040680.20597501
119Arachidonic acid metabolism_Homo sapiens_hsa005900.19965770
120Steroid biosynthesis_Homo sapiens_hsa001000.19764432

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