CASS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)5.30580413
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.18176054
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.18176054
4modulation by symbiont of host immune response (GO:0052553)5.18176054
5positive regulation by symbiont of host defense response (GO:0052509)5.18176054
6modulation by symbiont of host defense response (GO:0052031)5.18176054
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.18176054
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.16124571
9detection of molecule of bacterial origin (GO:0032490)5.07082725
10neutrophil activation involved in immune response (GO:0002283)5.05999201
11microglial cell activation (GO:0001774)4.91617401
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81868379
13regulation of B cell receptor signaling pathway (GO:0050855)4.75383667
14macrophage activation involved in immune response (GO:0002281)4.68327699
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.45266922
16detection of other organism (GO:0098543)4.36471055
17response to interleukin-15 (GO:0070672)4.35967573
18immunoglobulin mediated immune response (GO:0016064)4.35044735
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30645144
20negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.24612759
21neutrophil mediated immunity (GO:0002446)4.22871068
22detection of external biotic stimulus (GO:0098581)4.20086794
23respiratory burst (GO:0045730)4.19619741
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.17528353
25positive regulation of antigen processing and presentation (GO:0002579)4.15011566
26cellular response to interleukin-15 (GO:0071350)4.09390497
27positive regulation of gamma-delta T cell activation (GO:0046645)4.02303679
28regulation of gamma-delta T cell differentiation (GO:0045586)4.00949387
29myeloid cell activation involved in immune response (GO:0002275)3.91622981
30response to peptidoglycan (GO:0032494)3.91095881
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.90625000
32negative regulation of T-helper cell differentiation (GO:0045623)3.90625000
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.80823607
34neutrophil activation (GO:0042119)3.76187562
35detection of bacterium (GO:0016045)3.76013245
36mast cell activation (GO:0045576)3.75182992
37regulation of interferon-beta biosynthetic process (GO:0045357)3.74360347
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74060403
39detection of biotic stimulus (GO:0009595)3.73528174
40purinergic nucleotide receptor signaling pathway (GO:0035590)3.73052207
41positive regulation of B cell differentiation (GO:0045579)3.68984681
42negative regulation of granulocyte differentiation (GO:0030853)3.65099028
43negative regulation of T cell mediated immunity (GO:0002710)3.64972868
44myeloid dendritic cell activation (GO:0001773)3.64295917
45macrophage activation (GO:0042116)3.61844148
46myeloid dendritic cell differentiation (GO:0043011)3.60660468
47granulocyte activation (GO:0036230)3.58405870
48negative regulation of leukocyte mediated immunity (GO:0002704)3.57603491
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.56780161
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56632987
51response to host immune response (GO:0052572)3.56632987
52production of molecular mediator involved in inflammatory response (GO:0002532)3.53531386
53leukocyte migration involved in inflammatory response (GO:0002523)3.53354229
54antigen processing and presentation of endogenous antigen (GO:0019883)3.52940136
55leukocyte aggregation (GO:0070486)3.51810020
56myeloid leukocyte mediated immunity (GO:0002444)3.51608146
57regulation of B cell differentiation (GO:0045577)3.51234010
58pinocytosis (GO:0006907)3.50955460
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49147795
60response to host (GO:0075136)3.49147795
61response to host defenses (GO:0052200)3.49147795
62T cell migration (GO:0072678)3.47535929
63regulation of antigen processing and presentation (GO:0002577)3.46345368
64B cell mediated immunity (GO:0019724)3.45925556
65tolerance induction (GO:0002507)3.45576056
66regulation of T cell tolerance induction (GO:0002664)3.44886337
67G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.38452549
68response to muramyl dipeptide (GO:0032495)3.36574244
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.33659651
70regulation of memory T cell differentiation (GO:0043380)3.33259296
71NIK/NF-kappaB signaling (GO:0038061)3.32209328
72positive regulation of interferon-alpha production (GO:0032727)3.31073406
73interferon-gamma production (GO:0032609)3.29700546
74activated T cell proliferation (GO:0050798)3.25729263
75regulation of interferon-alpha production (GO:0032647)3.25390860
76regulation of alpha-beta T cell proliferation (GO:0046640)3.25293945
77dendritic cell chemotaxis (GO:0002407)3.24698442
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24258236
79regulation of T-helper 2 cell differentiation (GO:0045628)3.21446430
80regulation of mast cell activation involved in immune response (GO:0033006)3.20435578
81B cell receptor signaling pathway (GO:0050853)3.18760853
82neutrophil chemotaxis (GO:0030593)3.18497048
83myeloid leukocyte activation (GO:0002274)3.18332736
84dendritic cell migration (GO:0036336)3.16799380
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13384376
86regulation of T cell mediated cytotoxicity (GO:0001914)3.12303470
87defense response to protozoan (GO:0042832)3.11603650
88negative regulation of interleukin-12 production (GO:0032695)3.11421093
89positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11369368
90negative regulation of adaptive immune response (GO:0002820)3.11136310
91neutrophil migration (GO:1990266)3.10529446
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09646574
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08926668
94phagocytosis, engulfment (GO:0006911)3.08562078
95mast cell activation involved in immune response (GO:0002279)3.05369680
96mast cell degranulation (GO:0043303)3.05369680
97negative regulation of interleukin-6 production (GO:0032715)3.05062642
98eosinophil chemotaxis (GO:0048245)3.04306011
99regulation of natural killer cell mediated immunity (GO:0002715)3.03664144
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03664144
101dendritic cell differentiation (GO:0097028)2.99745116
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98075835
103germinal center formation (GO:0002467)2.97280265
104negative regulation of alpha-beta T cell activation (GO:0046636)2.95712371
105hepatocyte apoptotic process (GO:0097284)2.94796563
106positive T cell selection (GO:0043368)2.93873781
107eosinophil migration (GO:0072677)2.93677468
108positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.92718883
109superoxide anion generation (GO:0042554)2.92096572
110negative regulation of interleukin-1 production (GO:0032692)2.92042024
111purinergic receptor signaling pathway (GO:0035587)2.90931928
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90792915
113lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90646213
114positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89768759
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89747614
116regulation of regulatory T cell differentiation (GO:0045589)2.89741106
117positive regulation of mast cell activation (GO:0033005)2.89497663
118interferon-gamma-mediated signaling pathway (GO:0060333)2.88412439
119negative regulation of cell killing (GO:0031342)2.87753009
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87753009
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87702634
122positive regulation of interleukin-1 beta secretion (GO:0050718)2.87070692
123negative regulation of immunoglobulin mediated immune response (GO:0002890)2.86713174
124negative regulation of B cell mediated immunity (GO:0002713)2.86713174
125antigen processing and presentation via MHC class Ib (GO:0002475)2.86397684
126regulation of T cell receptor signaling pathway (GO:0050856)2.86292318
127regulation of mast cell activation (GO:0033003)2.84978401
128negative thymic T cell selection (GO:0045060)2.84763979
129cellular defense response (GO:0006968)2.84574215
130positive thymic T cell selection (GO:0045059)2.84438449
131modulation by virus of host process (GO:0019054)2.84315989
132positive regulation of monocyte chemotaxis (GO:0090026)2.83832392
133negative regulation of mast cell activation (GO:0033004)2.83747184
134leukocyte degranulation (GO:0043299)2.80984234
135regulation of mast cell degranulation (GO:0043304)2.80758846
136positive regulation of macrophage differentiation (GO:0045651)2.79614965
137mature B cell differentiation (GO:0002335)2.77077207
138negative T cell selection (GO:0043383)2.75820795
139modulation by symbiont of host cellular process (GO:0044068)2.74530645
140positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73453454
141cytokine secretion (GO:0050663)2.73152368
142negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.71785471
143positive regulation of mast cell degranulation (GO:0043306)2.71547424
144positive regulation of mast cell activation involved in immune response (GO:0033008)2.71547424
145adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.71414002
146regulation of gamma-delta T cell activation (GO:0046643)2.69709319
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69615694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.62863821
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.60296238
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.26215616
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.11204691
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.50637769
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.49657862
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.35066847
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.06450969
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.81728603
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.79157327
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.35526200
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28365225
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.28188666
14SCL_19346495_ChIP-Seq_HPC-7_Human3.19062835
15E2F7_22180533_ChIP-Seq_HELA_Human3.15621508
16MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07590635
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.67912549
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62626159
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59227757
20RUNX_20019798_ChIP-Seq_JUKART_Human2.51569625
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46056931
22SPI1_23547873_ChIP-Seq_NB4_Human2.38449099
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38444128
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34049224
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27795847
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27320327
27MYB_26560356_Chip-Seq_TH2_Human2.20851507
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.16352051
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15443396
30* VDR_24763502_ChIP-Seq_THP-1_Human2.11880084
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.99813401
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96863379
33SPI1_23127762_ChIP-Seq_K562_Human1.94304457
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92204296
35GATA1_22025678_ChIP-Seq_K562_Human1.90185208
36VDR_21846776_ChIP-Seq_THP-1_Human1.89999175
37MYB_26560356_Chip-Seq_TH1_Human1.87770585
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83255583
39MYC_22102868_ChIP-Seq_BL_Human1.82152684
40MAF_26560356_Chip-Seq_TH1_Human1.81930087
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77394590
42* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75569864
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74021608
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73940329
45PU_27001747_Chip-Seq_BMDM_Mouse1.73048626
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67644812
47VDR_24787735_ChIP-Seq_THP-1_Human1.64801443
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58566697
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.55923937
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55510475
51* TCF7_22412390_ChIP-Seq_EML_Mouse1.52134162
52UTX_26944678_Chip-Seq_JUKART_Human1.52127380
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46500282
54GATA3_27048872_Chip-Seq_THYMUS_Human1.37385186
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36473890
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32400920
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31617121
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29023971
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25953371
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22435957
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20992860
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16296113
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10745601
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10723205
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07931001
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05747187
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05347921
68* GATA3_26560356_Chip-Seq_TH2_Human1.03941255
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01843548
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01758285
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00929164
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98530367
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98267264
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96283234
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96020342
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95605274
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95000090
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.92207736
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91248374
80MAF_26560356_Chip-Seq_TH2_Human0.86057509
81* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85825723
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81768200
83* GATA2_19941826_ChIP-Seq_K562_Human0.81302065
84* GATA1_19941827_ChIP-Seq_MEL_Mouse0.80663175
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80086220
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79477472
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78700409
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76765490
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76636562
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76432266
91GATA3_26560356_Chip-Seq_TH1_Human0.76141012
92SPI1_20517297_ChIP-Seq_HL60_Human0.76028634
93* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74248209
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74077883
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.73687477
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73484358
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73332860
98SMRT_27268052_Chip-Seq_Bcells_Human0.72912595
99* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71736899
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71724514
101RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71378858
102STAT1_20625510_ChIP-Seq_HELA_Human0.71134538
103NCOR1_26117541_ChIP-Seq_K562_Human0.70978256
104BCL6_27268052_Chip-Seq_Bcells_Human0.70803412
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70711566
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70345924
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68712881
108KDM2B_26808549_Chip-Seq_DND41_Human0.68156590
109FOXM1_23109430_ChIP-Seq_U2OS_Human0.67653906
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.64688978
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64471938
112TP63_19390658_ChIP-ChIP_HaCaT_Human0.64448916
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64243621
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.61770575
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.61287727
116GATA1_19941826_ChIP-Seq_K562_Human0.60105908
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.60072423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.40120808
2MP0003436_decreased_susceptibility_to3.41987242
3MP0005671_abnormal_response_to3.37631830
4MP0005000_abnormal_immune_tolerance3.15579595
5MP0002148_abnormal_hypersensitivity_rea3.13678313
6MP0009785_altered_susceptibility_to3.12861611
7MP0000685_abnormal_immune_system3.08588614
8MP0002419_abnormal_innate_immunity3.08027323
9MP0002452_abnormal_antigen_presenting2.91620298
10MP0001800_abnormal_humoral_immune2.89211838
11MP0005025_abnormal_response_to2.79676396
12MP0006082_CNS_inflammation2.78667280
13MP0002723_abnormal_immune_serum2.65143253
14MP0005464_abnormal_platelet_physiology2.63904748
15MP0005387_immune_system_phenotype2.61789536
16MP0001790_abnormal_immune_system2.61789536
17MP0003303_peritoneal_inflammation2.59186929
18MP0001819_abnormal_immune_cell2.57039644
19MP0002420_abnormal_adaptive_immunity2.56165796
20MP0003763_abnormal_thymus_physiology2.52930846
21MP0002405_respiratory_system_inflammati2.33408965
22MP0003724_increased_susceptibility_to2.05172475
23MP0002398_abnormal_bone_marrow2.04827778
24MP0000716_abnormal_immune_system2.01134886
25MP0009333_abnormal_splenocyte_physiolog1.98021252
26MP0003191_abnormal_cellular_cholesterol1.94264584
27MP0001853_heart_inflammation1.83831791
28MP0005058_abnormal_lysosome_morphology1.80743730
29MP0002396_abnormal_hematopoietic_system1.80421179
30MP0001845_abnormal_inflammatory_respons1.79331313
31MP0001533_abnormal_skeleton_physiology1.77418039
32MP0000689_abnormal_spleen_morphology1.75597461
33MP0005310_abnormal_salivary_gland1.73981820
34MP0003183_abnormal_peptide_metabolism1.73889835
35MP0010155_abnormal_intestine_physiology1.71226723
36MP0000343_altered_response_to1.70407958
37MP0004947_skin_inflammation1.67920708
38MP0002722_abnormal_immune_system1.65824343
39MP0002429_abnormal_blood_cell1.65544934
40MP0001873_stomach_inflammation1.63169746
41MP0002254_reproductive_system_inflammat1.60450674
42MP0004381_abnormal_hair_follicle1.55040069
43MP0002166_altered_tumor_susceptibility1.54715617
44MP0002006_tumorigenesis1.52007088
45MP0008004_abnormal_stomach_pH1.51811752
46MP0004510_myositis1.42469172
47MP0003172_abnormal_lysosome_physiology1.42072365
48MP0002933_joint_inflammation1.40407441
49MP0003075_altered_response_to1.34748875
50MP0001851_eye_inflammation1.31971912
51MP0008469_abnormal_protein_level1.31073731
52MP0000703_abnormal_thymus_morphology1.30141558
53MP0009278_abnormal_bone_marrow1.28708090
54MP0003300_gastrointestinal_ulcer1.28413108
55MP0008260_abnormal_autophagy1.26347855
56MP0003448_altered_tumor_morphology1.25541415
57MP0005397_hematopoietic_system_phenotyp1.25054554
58MP0001545_abnormal_hematopoietic_system1.25054554
59MP0002998_abnormal_bone_remodeling1.22525603
60MP0004808_abnormal_hematopoietic_stem1.20707934
61MP0009764_decreased_sensitivity_to1.19806398
62MP0000858_altered_metastatic_potential1.19022653
63MP0002277_abnormal_respiratory_mucosa1.16797289
64MP0003828_pulmonary_edema1.14521343
65MP0005174_abnormal_tail_pigmentation1.14260863
66MP0004883_abnormal_blood_vessel1.12394321
67MP0000490_abnormal_crypts_of1.10654113
68MP0009840_abnormal_foam_cell1.10043383
69MP0000015_abnormal_ear_pigmentation1.08901056
70MP0010307_abnormal_tumor_latency1.07300984
71MP0003656_abnormal_erythrocyte_physiolo1.05860207
72MP0002132_abnormal_respiratory_system1.04366862
73MP0000465_gastrointestinal_hemorrhage1.03984443
74MP0005390_skeleton_phenotype1.02170410
75MP0005167_abnormal_blood-brain_barrier1.00521389
76MP0001986_abnormal_taste_sensitivity0.99258207
77MP0008007_abnormal_cellular_replicative0.94962937
78MP0005166_decreased_susceptibility_to0.93533463
79MP0010352_gastrointestinal_tract_polyps0.90954638
80MP0002009_preneoplasia0.90629201
81MP0005075_abnormal_melanosome_morpholog0.87700628
82MP0004484_altered_response_of0.85992494
83MP0009763_increased_sensitivity_to0.85754099
84MP0003690_abnormal_glial_cell0.84685550
85MP0000249_abnormal_blood_vessel0.84241671
86MP0004130_abnormal_muscle_cell0.83609972
87MP0004782_abnormal_surfactant_physiolog0.79920938
88MP0005164_abnormal_response_to0.76866128
89MP0003195_calcinosis0.72362701
90MP0002138_abnormal_hepatobiliary_system0.72342559
91MP0008877_abnormal_DNA_methylation0.71323772
92MP0003566_abnormal_cell_adhesion0.69885360
93MP0003795_abnormal_bone_structure0.69531605
94MP0000767_abnormal_smooth_muscle0.68870592
95MP0005023_abnormal_wound_healing0.67609886
96MP0000569_abnormal_digit_pigmentation0.67238223
97MP0003279_aneurysm0.66128361
98MP0005076_abnormal_cell_differentiation0.65935174
99MP0003866_abnormal_defecation0.65094804
100MP0000371_diluted_coat_color0.64919944
101MP0009115_abnormal_fat_cell0.64734433
102MP0003646_muscle_fatigue0.62556065
103MP0005451_abnormal_body_composition0.61959235
104MP0002332_abnormal_exercise_endurance0.59406310
105MP0003453_abnormal_keratinocyte_physiol0.58006580
106MP0002095_abnormal_skin_pigmentation0.57808536
107MP0002019_abnormal_tumor_incidence0.57610188
108MP0001663_abnormal_digestive_system0.56649897
109MP0002693_abnormal_pancreas_physiology0.55648675
110MP0005535_abnormal_body_temperature0.54780060
111MP0009765_abnormal_xenobiotic_induced0.54192168
112MP0003045_fibrosis0.53869926
113MP0008873_increased_physiological_sensi0.53754951
114MP0008874_decreased_physiological_sensi0.52720298
115MP0003878_abnormal_ear_physiology0.52458761
116MP0005377_hearing/vestibular/ear_phenot0.52458761
117MP0003091_abnormal_cell_migration0.51803554
118MP0000604_amyloidosis0.50148116
119MP0005376_homeostasis/metabolism_phenot0.49733106
120MP0002133_abnormal_respiratory_system0.47595370
121MP0005388_respiratory_system_phenotype0.47595370

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.84187882
2Recurrent abscess formation (HP:0002722)6.57129968
3Recurrent bacterial skin infections (HP:0005406)5.92013135
4Systemic lupus erythematosus (HP:0002725)4.67670736
5Recurrent gram-negative bacterial infections (HP:0005420)4.58217227
6Gastrointestinal infarctions (HP:0005244)4.51964263
7Recurrent fungal infections (HP:0002841)4.42533401
8Agnosia (HP:0010524)4.40203631
9Stomatitis (HP:0010280)4.36686122
10Myositis (HP:0100614)4.23611796
11Prostate neoplasm (HP:0100787)4.21954306
12Mediastinal lymphadenopathy (HP:0100721)4.21364634
13Recurrent skin infections (HP:0001581)3.98153307
14Elevated erythrocyte sedimentation rate (HP:0003565)3.83510688
15Abnormality of macrophages (HP:0004311)3.79484577
16Optic neuritis (HP:0100653)3.78475111
17Retrobulbar optic neuritis (HP:0100654)3.78475111
18Chronic mucocutaneous candidiasis (HP:0002728)3.74223557
19Recurrent cutaneous fungal infections (HP:0011370)3.74223557
20Orchitis (HP:0100796)3.70551524
21Obstructive lung disease (HP:0006536)3.65505136
22Chronic obstructive pulmonary disease (HP:0006510)3.65505136
23Glomerulonephritis (HP:0000099)3.62162174
24Gingivitis (HP:0000230)3.57345888
25Cellulitis (HP:0100658)3.54527371
26Spontaneous hematomas (HP:0007420)3.51456113
27Meningitis (HP:0001287)3.45510258
28Recurrent viral infections (HP:0004429)3.42273166
29Chest pain (HP:0100749)3.36809995
30Anorexia (HP:0002039)3.21678170
31Peritonitis (HP:0002586)3.20168062
32Agammaglobulinemia (HP:0004432)3.18199761
33Vacuolated lymphocytes (HP:0001922)3.17358203
34Episodic fever (HP:0001954)3.13833762
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.07269712
36IgM deficiency (HP:0002850)3.05994020
37Gingival bleeding (HP:0000225)3.02456695
38Thyroiditis (HP:0100646)3.00178524
39Vasculitis (HP:0002633)2.99461909
40Pulmonary infiltrates (HP:0002113)2.96285419
41Osteomyelitis (HP:0002754)2.95593518
42Pulmonary embolism (HP:0002204)2.92115890
43Gangrene (HP:0100758)2.84620305
44Eosinophilia (HP:0001880)2.78746724
45Hypochromic anemia (HP:0001931)2.74250939
46Keratoconjunctivitis (HP:0001096)2.73835716
47Panhypogammaglobulinemia (HP:0003139)2.73225805
48Abnormality of the prostate (HP:0008775)2.72460104
49Abnormality of glycolipid metabolism (HP:0010969)2.71899273
50Abnormality of liposaccharide metabolism (HP:0010968)2.71899273
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.71899273
52Hypochromic microcytic anemia (HP:0004840)2.69624740
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.67430859
54Inflammation of the large intestine (HP:0002037)2.66779760
55Chronic diarrhea (HP:0002028)2.66042911
56Increased cerebral lipofuscin (HP:0011813)2.65135452
57Leukocytosis (HP:0001974)2.64706516
58Colitis (HP:0002583)2.64149860
59Keratoconjunctivitis sicca (HP:0001097)2.62471250
60Gastrointestinal inflammation (HP:0004386)2.61734553
61Urticaria (HP:0001025)2.60182373
62Hematochezia (HP:0002573)2.59386071
63Recurrent pneumonia (HP:0006532)2.58976535
64Abnormality of eosinophils (HP:0001879)2.58156405
65Abnormality of the pleura (HP:0002103)2.56199592
66Severe combined immunodeficiency (HP:0004430)2.54334395
67Autoimmune thrombocytopenia (HP:0001973)2.54167953
68Petechiae (HP:0000967)2.50118727
69Abnormality of T cell number (HP:0011839)2.48837718
70Periodontitis (HP:0000704)2.47340278
71Keratitis (HP:0000491)2.46023578
72Chronic otitis media (HP:0000389)2.44363818
73Pustule (HP:0200039)2.42129526
74Interstitial pulmonary disease (HP:0006530)2.39950192
75Abnormality of the peritoneum (HP:0002585)2.39772297
76Arterial thrombosis (HP:0004420)2.37913600
77Increased IgM level (HP:0003496)2.35431890
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.34538218
79Osteolytic defects of the hand bones (HP:0009699)2.34538218
80Vertigo (HP:0002321)2.33442140
81Abnormality of T cells (HP:0002843)2.32088429
82Abnormality of T cell physiology (HP:0011840)2.32079383
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31963643
84Granulocytopenia (HP:0001913)2.31812661
85Basal ganglia calcification (HP:0002135)2.31626006
86Increased IgE level (HP:0003212)2.31598506
87Prolonged bleeding time (HP:0003010)2.30521099
88Recurrent lower respiratory tract infections (HP:0002783)2.28572818
89Abnormality of the endocardium (HP:0004306)2.28151567
90T lymphocytopenia (HP:0005403)2.27849547
91Dysostosis multiplex (HP:0000943)2.27193703
92Sepsis (HP:0100806)2.26459393
93Autoimmune hemolytic anemia (HP:0001890)2.24833907
94Disinhibition (HP:0000734)2.24548757
95Combined immunodeficiency (HP:0005387)2.24537437
96B lymphocytopenia (HP:0010976)2.21800152
97Abnormality of B cell number (HP:0010975)2.21800152
98Microcytic anemia (HP:0001935)2.21448030
99Glomerulopathy (HP:0100820)2.18254243
100Epistaxis (HP:0000421)2.17766157
101Alveolar cell carcinoma (HP:0006519)2.16398428
102Hemoptysis (HP:0002105)2.16175004
103Complement deficiency (HP:0004431)2.15533862
104Acne (HP:0001061)2.12708618
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.12559821
106Neoplasm of the tracheobronchial system (HP:0100552)2.12514088
107Lymphopenia (HP:0001888)2.12371943
108Upper motor neuron abnormality (HP:0002127)2.08362705
109Spondylolisthesis (HP:0003302)2.06917465
110Stomach cancer (HP:0012126)2.05286985
111Amyloidosis (HP:0011034)2.04883143
112Gastrointestinal stroma tumor (HP:0100723)2.04694470
113Abnormality of complement system (HP:0005339)2.01850287
114Hepatosplenomegaly (HP:0001433)2.01530558
115Encephalitis (HP:0002383)2.00142592
116Nephritis (HP:0000123)2.00111488
117Polyneuropathy (HP:0001271)1.99433745
118Intestinal fistula (HP:0100819)1.99333008
119Recurrent bronchitis (HP:0002837)1.99329715
120Axonal loss (HP:0003447)1.99174323
121Lymphoma (HP:0002665)1.98290252
122Segmental peripheral demyelination/remyelination (HP:0003481)1.95989181
123Premature loss of primary teeth (HP:0006323)1.94943589
124Hypergammaglobulinemia (HP:0010702)1.93740024
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93252777
126Rectal fistula (HP:0100590)1.90976801
127Rectovaginal fistula (HP:0000143)1.90976801
128Increased serum ferritin (HP:0003281)1.90713397
129IgG deficiency (HP:0004315)1.89597414
130Abnormality of iron homeostasis (HP:0011031)1.89580952
131Abnormal platelet volume (HP:0011876)1.89577951
132Viral hepatitis (HP:0006562)1.85996014
133Abnormality of transition element cation homeostasis (HP:0011030)1.85048464
134Joint swelling (HP:0001386)1.83906889
135Acute hepatic failure (HP:0006554)1.82384606
136Skin rash (HP:0000988)1.78108805
137Abnormality of the pericardium (HP:0001697)1.77414072
138Abnormality of the fingertips (HP:0001211)1.77413694
139Increased CSF protein (HP:0002922)1.77167761
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.76495861
141Cheilitis (HP:0100825)1.73892198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.72893381
2MAP3K143.56444423
3MAP4K13.47866815
4BLK3.29204414
5MAP3K103.27101049
6TXK2.84334917
7IRAK42.76183462
8STK102.60197142
9TYK22.40317377
10CSF1R2.30608356
11IKBKE2.28605004
12KIT2.16476507
13GRK72.09252528
14RIPK42.08454743
15BTK2.05910229
16PIK3CG2.01881284
17TBK11.99921968
18IKBKB1.93621451
19IRAK11.82204869
20TEC1.72734762
21ZAP701.71303538
22CLK11.70593049
23HCK1.68660826
24EPHB11.66524429
25ITK1.60863681
26EIF2AK21.60850429
27TGFBR11.56057608
28CHUK1.55535371
29JAK31.55205948
30SYK1.54384288
31IRAK31.50687492
32MAP3K21.43780964
33TNK21.41130163
34MAP3K31.37933572
35FLT31.37701438
36LCK1.35682261
37JAK11.33461556
38LYN1.31974137
39PIM11.26717786
40KSR21.26095615
41CDK81.25872784
42BMPR21.25143352
43CSK1.22124740
44BMPR1B1.17144546
45FGFR31.08267530
46MAP3K11.07902776
47PINK11.07286801
48PIM21.05499645
49MAPK151.05232558
50IRAK21.03216743
51TAOK31.03130598
52SIK31.02067501
53MAP3K131.01849931
54MAP3K110.98972546
55MATK0.98732234
56MAPKAPK20.98667623
57YES10.96848970
58PTK2B0.96161562
59TAOK10.96025438
60FRK0.95370269
61GRK60.94884814
62CDK90.93869992
63WNK10.89544410
64MOS0.87337478
65JAK20.84904316
66NEK90.82582265
67LRRK20.81077517
68CAMKK20.80779820
69EEF2K0.77740956
70FES0.75541920
71DAPK20.74038130
72ACVR1B0.73573291
73NLK0.71852142
74MAPK70.69953595
75GRK50.69098551
76ERN10.67043038
77MST40.66623239
78TSSK60.65603425
79MAP3K50.65199626
80FGFR40.64994757
81ADRBK20.64984338
82RAF10.64726129
83EPHA30.62897958
84CDK70.59925543
85HIPK20.58031340
86MARK20.56688428
87PRPF4B0.56281505
88MAP2K30.55441179
89PRKD20.54440819
90ADRBK10.53007577
91MARK30.52400271
92PDPK10.51537131
93PRKCD0.50130111
94BRD40.48616966
95TRPM70.48094476
96RPS6KA40.47358546
97RPS6KC10.46527966
98RPS6KL10.46527966
99PRKCQ0.46451107
100RPS6KA60.46251111
101SIK20.46068362
102STK110.44337663
103MAPK40.43841429
104MAP2K60.42924392
105CDK30.41993412
106MAP3K70.41291109
107MAP3K60.41031272
108KSR10.40751169
109EGFR0.40267426
110IGF1R0.39693967
111CDK120.39335709
112CDK60.38984488
113SGK20.37384065
114STK380.37358522
115PAK40.37194693
116SGK30.37169254
117MKNK10.37063668
118CDK40.36118515
119ABL10.35050109
120RPS6KA20.34407804
121RET0.33637933
122MAPKAPK50.32690155
123CDC42BPA0.32317414
124CAMK40.31981252
125FYN0.31630110
126STK40.31322252
127PTK60.29946174
128MAPK120.29867751
129MELK0.29866026
130VRK10.29775428
131CAMKK10.29116698
132ERBB30.28730359
133FGR0.28479777
134PDK10.25885238
135MAPK30.25844469

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.98980784
2Staphylococcus aureus infection_Homo sapiens_hsa051502.95080005
3Graft-versus-host disease_Homo sapiens_hsa053322.87313400
4Osteoclast differentiation_Homo sapiens_hsa043802.67959917
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60314036
6Primary immunodeficiency_Homo sapiens_hsa053402.55853956
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.51934499
8Allograft rejection_Homo sapiens_hsa053302.29908921
9Measles_Homo sapiens_hsa051622.28528122
10B cell receptor signaling pathway_Homo sapiens_hsa046622.26203199
11Antigen processing and presentation_Homo sapiens_hsa046122.18716082
12Hematopoietic cell lineage_Homo sapiens_hsa046402.14105986
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10779380
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07886359
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06108318
16Legionellosis_Homo sapiens_hsa051342.06059070
17Other glycan degradation_Homo sapiens_hsa005111.85413621
18Tuberculosis_Homo sapiens_hsa051521.76782934
19Asthma_Homo sapiens_hsa053101.76702500
20Malaria_Homo sapiens_hsa051441.76346306
21Pertussis_Homo sapiens_hsa051331.71400513
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65846408
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64371289
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63430261
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.59472632
26T cell receptor signaling pathway_Homo sapiens_hsa046601.58083383
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54735432
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.54193850
29Chemokine signaling pathway_Homo sapiens_hsa040621.52588984
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49185672
31Rheumatoid arthritis_Homo sapiens_hsa053231.46456462
32Toxoplasmosis_Homo sapiens_hsa051451.45571172
33Influenza A_Homo sapiens_hsa051641.45426272
34Autoimmune thyroid disease_Homo sapiens_hsa053201.43561917
35Lysosome_Homo sapiens_hsa041421.41668188
36Apoptosis_Homo sapiens_hsa042101.34945220
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32780983
38Type I diabetes mellitus_Homo sapiens_hsa049401.32673708
39Herpes simplex infection_Homo sapiens_hsa051681.28959733
40TNF signaling pathway_Homo sapiens_hsa046681.26322365
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26166449
42Salmonella infection_Homo sapiens_hsa051321.24176797
43Hepatitis B_Homo sapiens_hsa051611.21984281
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19716568
45Phagosome_Homo sapiens_hsa041451.19322300
46Acute myeloid leukemia_Homo sapiens_hsa052211.16779112
47African trypanosomiasis_Homo sapiens_hsa051431.16772012
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.15907461
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15720549
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11948034
51Chronic myeloid leukemia_Homo sapiens_hsa052201.06332588
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05074790
53Pancreatic cancer_Homo sapiens_hsa052121.02918541
54Non-homologous end-joining_Homo sapiens_hsa034501.01023329
55Shigellosis_Homo sapiens_hsa051310.98521404
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97155104
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96154614
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93210674
59Dorso-ventral axis formation_Homo sapiens_hsa043200.90669232
60Viral myocarditis_Homo sapiens_hsa054160.87573581
61Platelet activation_Homo sapiens_hsa046110.85707874
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78185549
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76544369
64HTLV-I infection_Homo sapiens_hsa051660.75858008
65Epstein-Barr virus infection_Homo sapiens_hsa051690.74540004
66Regulation of autophagy_Homo sapiens_hsa041400.73933008
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70837859
68Viral carcinogenesis_Homo sapiens_hsa052030.70251123
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70198977
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.69053413
71Hepatitis C_Homo sapiens_hsa051600.67106567
72Non-small cell lung cancer_Homo sapiens_hsa052230.61262163
73Amoebiasis_Homo sapiens_hsa051460.60239861
74Type II diabetes mellitus_Homo sapiens_hsa049300.59187719
75Colorectal cancer_Homo sapiens_hsa052100.58553606
76Prolactin signaling pathway_Homo sapiens_hsa049170.54157592
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.54104720
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52954612
79Complement and coagulation cascades_Homo sapiens_hsa046100.52282164
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48864054
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.48646775
82Small cell lung cancer_Homo sapiens_hsa052220.48617912
83Mismatch repair_Homo sapiens_hsa034300.47813193
84Prion diseases_Homo sapiens_hsa050200.47735146
85Insulin resistance_Homo sapiens_hsa049310.47396218
86Linoleic acid metabolism_Homo sapiens_hsa005910.46557542
87Choline metabolism in cancer_Homo sapiens_hsa052310.45536258
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43417594
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.42488994
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41893502
91Rap1 signaling pathway_Homo sapiens_hsa040150.39824216
92Endocytosis_Homo sapiens_hsa041440.37847199
93cAMP signaling pathway_Homo sapiens_hsa040240.37747577
94p53 signaling pathway_Homo sapiens_hsa041150.37497846
95Olfactory transduction_Homo sapiens_hsa047400.37406619
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37390595
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37078397
98Inositol phosphate metabolism_Homo sapiens_hsa005620.36583750
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.33193335
100Morphine addiction_Homo sapiens_hsa050320.32855176
101MAPK signaling pathway_Homo sapiens_hsa040100.32567695
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32149889
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31809836
104mTOR signaling pathway_Homo sapiens_hsa041500.31444549
105GnRH signaling pathway_Homo sapiens_hsa049120.31371884
106Notch signaling pathway_Homo sapiens_hsa043300.30701041
107Systemic lupus erythematosus_Homo sapiens_hsa053220.29635746
108Arachidonic acid metabolism_Homo sapiens_hsa005900.29211228
109Base excision repair_Homo sapiens_hsa034100.28951102
110HIF-1 signaling pathway_Homo sapiens_hsa040660.28907750
111FoxO signaling pathway_Homo sapiens_hsa040680.28875881
112Pathways in cancer_Homo sapiens_hsa052000.27759083
113VEGF signaling pathway_Homo sapiens_hsa043700.25837611
114Fanconi anemia pathway_Homo sapiens_hsa034600.25425969
115Homologous recombination_Homo sapiens_hsa034400.24297080
116Endometrial cancer_Homo sapiens_hsa052130.23692443
117MicroRNAs in cancer_Homo sapiens_hsa052060.23592102
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23501492
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23353118
120Proteoglycans in cancer_Homo sapiens_hsa052050.22426638
121Prostate cancer_Homo sapiens_hsa052150.21833961
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17898374
123Renal cell carcinoma_Homo sapiens_hsa052110.16638444

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