

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cellular extravasation (GO:0045123) | 5.30580413 |
| 2 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.18176054 |
| 3 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.18176054 |
| 4 | modulation by symbiont of host immune response (GO:0052553) | 5.18176054 |
| 5 | positive regulation by symbiont of host defense response (GO:0052509) | 5.18176054 |
| 6 | modulation by symbiont of host defense response (GO:0052031) | 5.18176054 |
| 7 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.18176054 |
| 8 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 5.16124571 |
| 9 | detection of molecule of bacterial origin (GO:0032490) | 5.07082725 |
| 10 | neutrophil activation involved in immune response (GO:0002283) | 5.05999201 |
| 11 | microglial cell activation (GO:0001774) | 4.91617401 |
| 12 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.81868379 |
| 13 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.75383667 |
| 14 | macrophage activation involved in immune response (GO:0002281) | 4.68327699 |
| 15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.45266922 |
| 16 | detection of other organism (GO:0098543) | 4.36471055 |
| 17 | response to interleukin-15 (GO:0070672) | 4.35967573 |
| 18 | immunoglobulin mediated immune response (GO:0016064) | 4.35044735 |
| 19 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.30645144 |
| 20 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.24612759 |
| 21 | neutrophil mediated immunity (GO:0002446) | 4.22871068 |
| 22 | detection of external biotic stimulus (GO:0098581) | 4.20086794 |
| 23 | respiratory burst (GO:0045730) | 4.19619741 |
| 24 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.17528353 |
| 25 | positive regulation of antigen processing and presentation (GO:0002579) | 4.15011566 |
| 26 | cellular response to interleukin-15 (GO:0071350) | 4.09390497 |
| 27 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.02303679 |
| 28 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.00949387 |
| 29 | myeloid cell activation involved in immune response (GO:0002275) | 3.91622981 |
| 30 | response to peptidoglycan (GO:0032494) | 3.91095881 |
| 31 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.90625000 |
| 32 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.90625000 |
| 33 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.80823607 |
| 34 | neutrophil activation (GO:0042119) | 3.76187562 |
| 35 | detection of bacterium (GO:0016045) | 3.76013245 |
| 36 | mast cell activation (GO:0045576) | 3.75182992 |
| 37 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.74360347 |
| 38 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.74060403 |
| 39 | detection of biotic stimulus (GO:0009595) | 3.73528174 |
| 40 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 3.73052207 |
| 41 | positive regulation of B cell differentiation (GO:0045579) | 3.68984681 |
| 42 | negative regulation of granulocyte differentiation (GO:0030853) | 3.65099028 |
| 43 | negative regulation of T cell mediated immunity (GO:0002710) | 3.64972868 |
| 44 | myeloid dendritic cell activation (GO:0001773) | 3.64295917 |
| 45 | macrophage activation (GO:0042116) | 3.61844148 |
| 46 | myeloid dendritic cell differentiation (GO:0043011) | 3.60660468 |
| 47 | granulocyte activation (GO:0036230) | 3.58405870 |
| 48 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.57603491 |
| 49 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.56780161 |
| 50 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.56632987 |
| 51 | response to host immune response (GO:0052572) | 3.56632987 |
| 52 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.53531386 |
| 53 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.53354229 |
| 54 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.52940136 |
| 55 | leukocyte aggregation (GO:0070486) | 3.51810020 |
| 56 | myeloid leukocyte mediated immunity (GO:0002444) | 3.51608146 |
| 57 | regulation of B cell differentiation (GO:0045577) | 3.51234010 |
| 58 | pinocytosis (GO:0006907) | 3.50955460 |
| 59 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.49147795 |
| 60 | response to host (GO:0075136) | 3.49147795 |
| 61 | response to host defenses (GO:0052200) | 3.49147795 |
| 62 | T cell migration (GO:0072678) | 3.47535929 |
| 63 | regulation of antigen processing and presentation (GO:0002577) | 3.46345368 |
| 64 | B cell mediated immunity (GO:0019724) | 3.45925556 |
| 65 | tolerance induction (GO:0002507) | 3.45576056 |
| 66 | regulation of T cell tolerance induction (GO:0002664) | 3.44886337 |
| 67 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 3.38452549 |
| 68 | response to muramyl dipeptide (GO:0032495) | 3.36574244 |
| 69 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.33659651 |
| 70 | regulation of memory T cell differentiation (GO:0043380) | 3.33259296 |
| 71 | NIK/NF-kappaB signaling (GO:0038061) | 3.32209328 |
| 72 | positive regulation of interferon-alpha production (GO:0032727) | 3.31073406 |
| 73 | interferon-gamma production (GO:0032609) | 3.29700546 |
| 74 | activated T cell proliferation (GO:0050798) | 3.25729263 |
| 75 | regulation of interferon-alpha production (GO:0032647) | 3.25390860 |
| 76 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.25293945 |
| 77 | dendritic cell chemotaxis (GO:0002407) | 3.24698442 |
| 78 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.24258236 |
| 79 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.21446430 |
| 80 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.20435578 |
| 81 | B cell receptor signaling pathway (GO:0050853) | 3.18760853 |
| 82 | neutrophil chemotaxis (GO:0030593) | 3.18497048 |
| 83 | myeloid leukocyte activation (GO:0002274) | 3.18332736 |
| 84 | dendritic cell migration (GO:0036336) | 3.16799380 |
| 85 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.13384376 |
| 86 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.12303470 |
| 87 | defense response to protozoan (GO:0042832) | 3.11603650 |
| 88 | negative regulation of interleukin-12 production (GO:0032695) | 3.11421093 |
| 89 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.11369368 |
| 90 | negative regulation of adaptive immune response (GO:0002820) | 3.11136310 |
| 91 | neutrophil migration (GO:1990266) | 3.10529446 |
| 92 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.09646574 |
| 93 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.08926668 |
| 94 | phagocytosis, engulfment (GO:0006911) | 3.08562078 |
| 95 | mast cell activation involved in immune response (GO:0002279) | 3.05369680 |
| 96 | mast cell degranulation (GO:0043303) | 3.05369680 |
| 97 | negative regulation of interleukin-6 production (GO:0032715) | 3.05062642 |
| 98 | eosinophil chemotaxis (GO:0048245) | 3.04306011 |
| 99 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.03664144 |
| 100 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.03664144 |
| 101 | dendritic cell differentiation (GO:0097028) | 2.99745116 |
| 102 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.98075835 |
| 103 | germinal center formation (GO:0002467) | 2.97280265 |
| 104 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.95712371 |
| 105 | hepatocyte apoptotic process (GO:0097284) | 2.94796563 |
| 106 | positive T cell selection (GO:0043368) | 2.93873781 |
| 107 | eosinophil migration (GO:0072677) | 2.93677468 |
| 108 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.92718883 |
| 109 | superoxide anion generation (GO:0042554) | 2.92096572 |
| 110 | negative regulation of interleukin-1 production (GO:0032692) | 2.92042024 |
| 111 | purinergic receptor signaling pathway (GO:0035587) | 2.90931928 |
| 112 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.90792915 |
| 113 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.90646213 |
| 114 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.89768759 |
| 115 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.89747614 |
| 116 | regulation of regulatory T cell differentiation (GO:0045589) | 2.89741106 |
| 117 | positive regulation of mast cell activation (GO:0033005) | 2.89497663 |
| 118 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.88412439 |
| 119 | negative regulation of cell killing (GO:0031342) | 2.87753009 |
| 120 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.87753009 |
| 121 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.87702634 |
| 122 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.87070692 |
| 123 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 2.86713174 |
| 124 | negative regulation of B cell mediated immunity (GO:0002713) | 2.86713174 |
| 125 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.86397684 |
| 126 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.86292318 |
| 127 | regulation of mast cell activation (GO:0033003) | 2.84978401 |
| 128 | negative thymic T cell selection (GO:0045060) | 2.84763979 |
| 129 | cellular defense response (GO:0006968) | 2.84574215 |
| 130 | positive thymic T cell selection (GO:0045059) | 2.84438449 |
| 131 | modulation by virus of host process (GO:0019054) | 2.84315989 |
| 132 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.83832392 |
| 133 | negative regulation of mast cell activation (GO:0033004) | 2.83747184 |
| 134 | leukocyte degranulation (GO:0043299) | 2.80984234 |
| 135 | regulation of mast cell degranulation (GO:0043304) | 2.80758846 |
| 136 | positive regulation of macrophage differentiation (GO:0045651) | 2.79614965 |
| 137 | mature B cell differentiation (GO:0002335) | 2.77077207 |
| 138 | negative T cell selection (GO:0043383) | 2.75820795 |
| 139 | modulation by symbiont of host cellular process (GO:0044068) | 2.74530645 |
| 140 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.73453454 |
| 141 | cytokine secretion (GO:0050663) | 2.73152368 |
| 142 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.71785471 |
| 143 | positive regulation of mast cell degranulation (GO:0043306) | 2.71547424 |
| 144 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.71547424 |
| 145 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.71414002 |
| 146 | regulation of gamma-delta T cell activation (GO:0046643) | 2.69709319 |
| 147 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.69615694 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 5.62863821 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.60296238 |
| 3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.26215616 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.11204691 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.50637769 |
| 6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.49657862 |
| 7 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.35066847 |
| 8 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.06450969 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.81728603 |
| 10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.79157327 |
| 11 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.35526200 |
| 12 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.28365225 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.28188666 |
| 14 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.19062835 |
| 15 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.15621508 |
| 16 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.07590635 |
| 17 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.67912549 |
| 18 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.62626159 |
| 19 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.59227757 |
| 20 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.51569625 |
| 21 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.46056931 |
| 22 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.38449099 |
| 23 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.38444128 |
| 24 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.34049224 |
| 25 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.27795847 |
| 26 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.27320327 |
| 27 | MYB_26560356_Chip-Seq_TH2_Human | 2.20851507 |
| 28 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.16352051 |
| 29 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.15443396 |
| 30 | * VDR_24763502_ChIP-Seq_THP-1_Human | 2.11880084 |
| 31 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.99813401 |
| 32 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.96863379 |
| 33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.94304457 |
| 34 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.92204296 |
| 35 | GATA1_22025678_ChIP-Seq_K562_Human | 1.90185208 |
| 36 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.89999175 |
| 37 | MYB_26560356_Chip-Seq_TH1_Human | 1.87770585 |
| 38 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.83255583 |
| 39 | MYC_22102868_ChIP-Seq_BL_Human | 1.82152684 |
| 40 | MAF_26560356_Chip-Seq_TH1_Human | 1.81930087 |
| 41 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77394590 |
| 42 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.75569864 |
| 43 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74021608 |
| 44 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.73940329 |
| 45 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.73048626 |
| 46 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.67644812 |
| 47 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.64801443 |
| 48 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.58566697 |
| 49 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.55923937 |
| 50 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.55510475 |
| 51 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.52134162 |
| 52 | UTX_26944678_Chip-Seq_JUKART_Human | 1.52127380 |
| 53 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.46500282 |
| 54 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.37385186 |
| 55 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.36473890 |
| 56 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.32400920 |
| 57 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.31617121 |
| 58 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.29023971 |
| 59 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.25953371 |
| 60 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.22435957 |
| 61 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.20992860 |
| 62 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.16296113 |
| 63 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10745601 |
| 64 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.10723205 |
| 65 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07931001 |
| 66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05747187 |
| 67 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.05347921 |
| 68 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.03941255 |
| 69 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.01843548 |
| 70 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01758285 |
| 71 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.00929164 |
| 72 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.98530367 |
| 73 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98267264 |
| 74 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.96283234 |
| 75 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96020342 |
| 76 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.95605274 |
| 77 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.95000090 |
| 78 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.92207736 |
| 79 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.91248374 |
| 80 | MAF_26560356_Chip-Seq_TH2_Human | 0.86057509 |
| 81 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85825723 |
| 82 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.81768200 |
| 83 | * GATA2_19941826_ChIP-Seq_K562_Human | 0.81302065 |
| 84 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.80663175 |
| 85 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.80086220 |
| 86 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.79477472 |
| 87 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.78700409 |
| 88 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.76765490 |
| 89 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.76636562 |
| 90 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76432266 |
| 91 | GATA3_26560356_Chip-Seq_TH1_Human | 0.76141012 |
| 92 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.76028634 |
| 93 | * TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.74248209 |
| 94 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.74077883 |
| 95 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.73687477 |
| 96 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.73484358 |
| 97 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.73332860 |
| 98 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.72912595 |
| 99 | * TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.71736899 |
| 100 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.71724514 |
| 101 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71378858 |
| 102 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.71134538 |
| 103 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.70978256 |
| 104 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.70803412 |
| 105 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.70711566 |
| 106 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.70345924 |
| 107 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.68712881 |
| 108 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.68156590 |
| 109 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.67653906 |
| 110 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.64688978 |
| 111 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.64471938 |
| 112 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.64448916 |
| 113 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.64243621 |
| 114 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.61770575 |
| 115 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.61287727 |
| 116 | GATA1_19941826_ChIP-Seq_K562_Human | 0.60105908 |
| 117 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.60072423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 5.40120808 |
| 2 | MP0003436_decreased_susceptibility_to | 3.41987242 |
| 3 | MP0005671_abnormal_response_to | 3.37631830 |
| 4 | MP0005000_abnormal_immune_tolerance | 3.15579595 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 3.13678313 |
| 6 | MP0009785_altered_susceptibility_to | 3.12861611 |
| 7 | MP0000685_abnormal_immune_system | 3.08588614 |
| 8 | MP0002419_abnormal_innate_immunity | 3.08027323 |
| 9 | MP0002452_abnormal_antigen_presenting | 2.91620298 |
| 10 | MP0001800_abnormal_humoral_immune | 2.89211838 |
| 11 | MP0005025_abnormal_response_to | 2.79676396 |
| 12 | MP0006082_CNS_inflammation | 2.78667280 |
| 13 | MP0002723_abnormal_immune_serum | 2.65143253 |
| 14 | MP0005464_abnormal_platelet_physiology | 2.63904748 |
| 15 | MP0001790_abnormal_immune_system | 2.61789536 |
| 16 | MP0005387_immune_system_phenotype | 2.61789536 |
| 17 | MP0003303_peritoneal_inflammation | 2.59186929 |
| 18 | MP0001819_abnormal_immune_cell | 2.57039644 |
| 19 | MP0002420_abnormal_adaptive_immunity | 2.56165796 |
| 20 | MP0003763_abnormal_thymus_physiology | 2.52930846 |
| 21 | MP0002405_respiratory_system_inflammati | 2.33408965 |
| 22 | MP0003724_increased_susceptibility_to | 2.05172475 |
| 23 | MP0002398_abnormal_bone_marrow | 2.04827778 |
| 24 | MP0000716_abnormal_immune_system | 2.01134886 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 1.98021252 |
| 26 | MP0003191_abnormal_cellular_cholesterol | 1.94264584 |
| 27 | MP0001853_heart_inflammation | 1.83831791 |
| 28 | MP0005058_abnormal_lysosome_morphology | 1.80743730 |
| 29 | MP0002396_abnormal_hematopoietic_system | 1.80421179 |
| 30 | MP0001845_abnormal_inflammatory_respons | 1.79331313 |
| 31 | MP0001533_abnormal_skeleton_physiology | 1.77418039 |
| 32 | MP0000689_abnormal_spleen_morphology | 1.75597461 |
| 33 | MP0005310_abnormal_salivary_gland | 1.73981820 |
| 34 | MP0003183_abnormal_peptide_metabolism | 1.73889835 |
| 35 | MP0010155_abnormal_intestine_physiology | 1.71226723 |
| 36 | MP0000343_altered_response_to | 1.70407958 |
| 37 | MP0004947_skin_inflammation | 1.67920708 |
| 38 | MP0002722_abnormal_immune_system | 1.65824343 |
| 39 | MP0002429_abnormal_blood_cell | 1.65544934 |
| 40 | MP0001873_stomach_inflammation | 1.63169746 |
| 41 | MP0002254_reproductive_system_inflammat | 1.60450674 |
| 42 | MP0004381_abnormal_hair_follicle | 1.55040069 |
| 43 | MP0002166_altered_tumor_susceptibility | 1.54715617 |
| 44 | MP0002006_tumorigenesis | 1.52007088 |
| 45 | MP0008004_abnormal_stomach_pH | 1.51811752 |
| 46 | MP0004510_myositis | 1.42469172 |
| 47 | MP0003172_abnormal_lysosome_physiology | 1.42072365 |
| 48 | MP0002933_joint_inflammation | 1.40407441 |
| 49 | MP0003075_altered_response_to | 1.34748875 |
| 50 | MP0001851_eye_inflammation | 1.31971912 |
| 51 | MP0008469_abnormal_protein_level | 1.31073731 |
| 52 | MP0000703_abnormal_thymus_morphology | 1.30141558 |
| 53 | MP0009278_abnormal_bone_marrow | 1.28708090 |
| 54 | MP0003300_gastrointestinal_ulcer | 1.28413108 |
| 55 | MP0008260_abnormal_autophagy | 1.26347855 |
| 56 | MP0003448_altered_tumor_morphology | 1.25541415 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.25054554 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.25054554 |
| 59 | MP0002998_abnormal_bone_remodeling | 1.22525603 |
| 60 | MP0004808_abnormal_hematopoietic_stem | 1.20707934 |
| 61 | MP0009764_decreased_sensitivity_to | 1.19806398 |
| 62 | MP0000858_altered_metastatic_potential | 1.19022653 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 1.16797289 |
| 64 | MP0003828_pulmonary_edema | 1.14521343 |
| 65 | MP0005174_abnormal_tail_pigmentation | 1.14260863 |
| 66 | MP0004883_abnormal_blood_vessel | 1.12394321 |
| 67 | MP0000490_abnormal_crypts_of | 1.10654113 |
| 68 | MP0009840_abnormal_foam_cell | 1.10043383 |
| 69 | MP0000015_abnormal_ear_pigmentation | 1.08901056 |
| 70 | MP0010307_abnormal_tumor_latency | 1.07300984 |
| 71 | MP0003656_abnormal_erythrocyte_physiolo | 1.05860207 |
| 72 | MP0002132_abnormal_respiratory_system | 1.04366862 |
| 73 | MP0000465_gastrointestinal_hemorrhage | 1.03984443 |
| 74 | MP0005390_skeleton_phenotype | 1.02170410 |
| 75 | MP0005167_abnormal_blood-brain_barrier | 1.00521389 |
| 76 | MP0001986_abnormal_taste_sensitivity | 0.99258207 |
| 77 | MP0008007_abnormal_cellular_replicative | 0.94962937 |
| 78 | MP0005166_decreased_susceptibility_to | 0.93533463 |
| 79 | MP0010352_gastrointestinal_tract_polyps | 0.90954638 |
| 80 | MP0002009_preneoplasia | 0.90629201 |
| 81 | MP0005075_abnormal_melanosome_morpholog | 0.87700628 |
| 82 | MP0004484_altered_response_of | 0.85992494 |
| 83 | MP0009763_increased_sensitivity_to | 0.85754099 |
| 84 | MP0003690_abnormal_glial_cell | 0.84685550 |
| 85 | MP0000249_abnormal_blood_vessel | 0.84241671 |
| 86 | MP0004130_abnormal_muscle_cell | 0.83609972 |
| 87 | MP0004782_abnormal_surfactant_physiolog | 0.79920938 |
| 88 | MP0005164_abnormal_response_to | 0.76866128 |
| 89 | MP0003195_calcinosis | 0.72362701 |
| 90 | MP0002138_abnormal_hepatobiliary_system | 0.72342559 |
| 91 | MP0008877_abnormal_DNA_methylation | 0.71323772 |
| 92 | MP0003566_abnormal_cell_adhesion | 0.69885360 |
| 93 | MP0003795_abnormal_bone_structure | 0.69531605 |
| 94 | MP0000767_abnormal_smooth_muscle | 0.68870592 |
| 95 | MP0005023_abnormal_wound_healing | 0.67609886 |
| 96 | MP0000569_abnormal_digit_pigmentation | 0.67238223 |
| 97 | MP0003279_aneurysm | 0.66128361 |
| 98 | MP0005076_abnormal_cell_differentiation | 0.65935174 |
| 99 | MP0003866_abnormal_defecation | 0.65094804 |
| 100 | MP0000371_diluted_coat_color | 0.64919944 |
| 101 | MP0009115_abnormal_fat_cell | 0.64734433 |
| 102 | MP0003646_muscle_fatigue | 0.62556065 |
| 103 | MP0005451_abnormal_body_composition | 0.61959235 |
| 104 | MP0002332_abnormal_exercise_endurance | 0.59406310 |
| 105 | MP0003453_abnormal_keratinocyte_physiol | 0.58006580 |
| 106 | MP0002095_abnormal_skin_pigmentation | 0.57808536 |
| 107 | MP0002019_abnormal_tumor_incidence | 0.57610188 |
| 108 | MP0001663_abnormal_digestive_system | 0.56649897 |
| 109 | MP0002693_abnormal_pancreas_physiology | 0.55648675 |
| 110 | MP0005535_abnormal_body_temperature | 0.54780060 |
| 111 | MP0009765_abnormal_xenobiotic_induced | 0.54192168 |
| 112 | MP0003045_fibrosis | 0.53869926 |
| 113 | MP0008873_increased_physiological_sensi | 0.53754951 |
| 114 | MP0008874_decreased_physiological_sensi | 0.52720298 |
| 115 | MP0005377_hearing/vestibular/ear_phenot | 0.52458761 |
| 116 | MP0003878_abnormal_ear_physiology | 0.52458761 |
| 117 | MP0003091_abnormal_cell_migration | 0.51803554 |
| 118 | MP0000604_amyloidosis | 0.50148116 |
| 119 | MP0005376_homeostasis/metabolism_phenot | 0.49733106 |
| 120 | MP0005388_respiratory_system_phenotype | 0.47595370 |
| 121 | MP0002133_abnormal_respiratory_system | 0.47595370 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 6.84187882 |
| 2 | Recurrent abscess formation (HP:0002722) | 6.57129968 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 5.92013135 |
| 4 | Systemic lupus erythematosus (HP:0002725) | 4.67670736 |
| 5 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.58217227 |
| 6 | Gastrointestinal infarctions (HP:0005244) | 4.51964263 |
| 7 | Recurrent fungal infections (HP:0002841) | 4.42533401 |
| 8 | Agnosia (HP:0010524) | 4.40203631 |
| 9 | Stomatitis (HP:0010280) | 4.36686122 |
| 10 | Myositis (HP:0100614) | 4.23611796 |
| 11 | Prostate neoplasm (HP:0100787) | 4.21954306 |
| 12 | Mediastinal lymphadenopathy (HP:0100721) | 4.21364634 |
| 13 | Recurrent skin infections (HP:0001581) | 3.98153307 |
| 14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.83510688 |
| 15 | Abnormality of macrophages (HP:0004311) | 3.79484577 |
| 16 | Optic neuritis (HP:0100653) | 3.78475111 |
| 17 | Retrobulbar optic neuritis (HP:0100654) | 3.78475111 |
| 18 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.74223557 |
| 19 | Recurrent cutaneous fungal infections (HP:0011370) | 3.74223557 |
| 20 | Orchitis (HP:0100796) | 3.70551524 |
| 21 | Obstructive lung disease (HP:0006536) | 3.65505136 |
| 22 | Chronic obstructive pulmonary disease (HP:0006510) | 3.65505136 |
| 23 | Glomerulonephritis (HP:0000099) | 3.62162174 |
| 24 | Gingivitis (HP:0000230) | 3.57345888 |
| 25 | Cellulitis (HP:0100658) | 3.54527371 |
| 26 | Spontaneous hematomas (HP:0007420) | 3.51456113 |
| 27 | Meningitis (HP:0001287) | 3.45510258 |
| 28 | Recurrent viral infections (HP:0004429) | 3.42273166 |
| 29 | Chest pain (HP:0100749) | 3.36809995 |
| 30 | Anorexia (HP:0002039) | 3.21678170 |
| 31 | Peritonitis (HP:0002586) | 3.20168062 |
| 32 | Agammaglobulinemia (HP:0004432) | 3.18199761 |
| 33 | Vacuolated lymphocytes (HP:0001922) | 3.17358203 |
| 34 | Episodic fever (HP:0001954) | 3.13833762 |
| 35 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.07269712 |
| 36 | IgM deficiency (HP:0002850) | 3.05994020 |
| 37 | Gingival bleeding (HP:0000225) | 3.02456695 |
| 38 | Thyroiditis (HP:0100646) | 3.00178524 |
| 39 | Vasculitis (HP:0002633) | 2.99461909 |
| 40 | Pulmonary infiltrates (HP:0002113) | 2.96285419 |
| 41 | Osteomyelitis (HP:0002754) | 2.95593518 |
| 42 | Pulmonary embolism (HP:0002204) | 2.92115890 |
| 43 | Gangrene (HP:0100758) | 2.84620305 |
| 44 | Eosinophilia (HP:0001880) | 2.78746724 |
| 45 | Hypochromic anemia (HP:0001931) | 2.74250939 |
| 46 | Keratoconjunctivitis (HP:0001096) | 2.73835716 |
| 47 | Panhypogammaglobulinemia (HP:0003139) | 2.73225805 |
| 48 | Abnormality of the prostate (HP:0008775) | 2.72460104 |
| 49 | Abnormality of glycolipid metabolism (HP:0010969) | 2.71899273 |
| 50 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.71899273 |
| 51 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.71899273 |
| 52 | Hypochromic microcytic anemia (HP:0004840) | 2.69624740 |
| 53 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.67430859 |
| 54 | Inflammation of the large intestine (HP:0002037) | 2.66779760 |
| 55 | Chronic diarrhea (HP:0002028) | 2.66042911 |
| 56 | Increased cerebral lipofuscin (HP:0011813) | 2.65135452 |
| 57 | Leukocytosis (HP:0001974) | 2.64706516 |
| 58 | Colitis (HP:0002583) | 2.64149860 |
| 59 | Keratoconjunctivitis sicca (HP:0001097) | 2.62471250 |
| 60 | Gastrointestinal inflammation (HP:0004386) | 2.61734553 |
| 61 | Urticaria (HP:0001025) | 2.60182373 |
| 62 | Hematochezia (HP:0002573) | 2.59386071 |
| 63 | Recurrent pneumonia (HP:0006532) | 2.58976535 |
| 64 | Abnormality of eosinophils (HP:0001879) | 2.58156405 |
| 65 | Abnormality of the pleura (HP:0002103) | 2.56199592 |
| 66 | Severe combined immunodeficiency (HP:0004430) | 2.54334395 |
| 67 | Autoimmune thrombocytopenia (HP:0001973) | 2.54167953 |
| 68 | Petechiae (HP:0000967) | 2.50118727 |
| 69 | Abnormality of T cell number (HP:0011839) | 2.48837718 |
| 70 | Periodontitis (HP:0000704) | 2.47340278 |
| 71 | Keratitis (HP:0000491) | 2.46023578 |
| 72 | Chronic otitis media (HP:0000389) | 2.44363818 |
| 73 | Pustule (HP:0200039) | 2.42129526 |
| 74 | Interstitial pulmonary disease (HP:0006530) | 2.39950192 |
| 75 | Abnormality of the peritoneum (HP:0002585) | 2.39772297 |
| 76 | Arterial thrombosis (HP:0004420) | 2.37913600 |
| 77 | Increased IgM level (HP:0003496) | 2.35431890 |
| 78 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.34538218 |
| 79 | Osteolytic defects of the hand bones (HP:0009699) | 2.34538218 |
| 80 | Vertigo (HP:0002321) | 2.33442140 |
| 81 | Abnormality of T cells (HP:0002843) | 2.32088429 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 2.32079383 |
| 83 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.31963643 |
| 84 | Granulocytopenia (HP:0001913) | 2.31812661 |
| 85 | Basal ganglia calcification (HP:0002135) | 2.31626006 |
| 86 | Increased IgE level (HP:0003212) | 2.31598506 |
| 87 | Prolonged bleeding time (HP:0003010) | 2.30521099 |
| 88 | Recurrent lower respiratory tract infections (HP:0002783) | 2.28572818 |
| 89 | Abnormality of the endocardium (HP:0004306) | 2.28151567 |
| 90 | T lymphocytopenia (HP:0005403) | 2.27849547 |
| 91 | Dysostosis multiplex (HP:0000943) | 2.27193703 |
| 92 | Sepsis (HP:0100806) | 2.26459393 |
| 93 | Autoimmune hemolytic anemia (HP:0001890) | 2.24833907 |
| 94 | Disinhibition (HP:0000734) | 2.24548757 |
| 95 | Combined immunodeficiency (HP:0005387) | 2.24537437 |
| 96 | B lymphocytopenia (HP:0010976) | 2.21800152 |
| 97 | Abnormality of B cell number (HP:0010975) | 2.21800152 |
| 98 | Microcytic anemia (HP:0001935) | 2.21448030 |
| 99 | Glomerulopathy (HP:0100820) | 2.18254243 |
| 100 | Epistaxis (HP:0000421) | 2.17766157 |
| 101 | Alveolar cell carcinoma (HP:0006519) | 2.16398428 |
| 102 | Hemoptysis (HP:0002105) | 2.16175004 |
| 103 | Complement deficiency (HP:0004431) | 2.15533862 |
| 104 | Acne (HP:0001061) | 2.12708618 |
| 105 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.12559821 |
| 106 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.12514088 |
| 107 | Lymphopenia (HP:0001888) | 2.12371943 |
| 108 | Upper motor neuron abnormality (HP:0002127) | 2.08362705 |
| 109 | Spondylolisthesis (HP:0003302) | 2.06917465 |
| 110 | Stomach cancer (HP:0012126) | 2.05286985 |
| 111 | Amyloidosis (HP:0011034) | 2.04883143 |
| 112 | Gastrointestinal stroma tumor (HP:0100723) | 2.04694470 |
| 113 | Abnormality of complement system (HP:0005339) | 2.01850287 |
| 114 | Hepatosplenomegaly (HP:0001433) | 2.01530558 |
| 115 | Encephalitis (HP:0002383) | 2.00142592 |
| 116 | Nephritis (HP:0000123) | 2.00111488 |
| 117 | Polyneuropathy (HP:0001271) | 1.99433745 |
| 118 | Intestinal fistula (HP:0100819) | 1.99333008 |
| 119 | Recurrent bronchitis (HP:0002837) | 1.99329715 |
| 120 | Axonal loss (HP:0003447) | 1.99174323 |
| 121 | Lymphoma (HP:0002665) | 1.98290252 |
| 122 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.95989181 |
| 123 | Premature loss of primary teeth (HP:0006323) | 1.94943589 |
| 124 | Hypergammaglobulinemia (HP:0010702) | 1.93740024 |
| 125 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.93252777 |
| 126 | Rectal fistula (HP:0100590) | 1.90976801 |
| 127 | Rectovaginal fistula (HP:0000143) | 1.90976801 |
| 128 | Increased serum ferritin (HP:0003281) | 1.90713397 |
| 129 | IgG deficiency (HP:0004315) | 1.89597414 |
| 130 | Abnormality of iron homeostasis (HP:0011031) | 1.89580952 |
| 131 | Abnormal platelet volume (HP:0011876) | 1.89577951 |
| 132 | Viral hepatitis (HP:0006562) | 1.85996014 |
| 133 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.85048464 |
| 134 | Joint swelling (HP:0001386) | 1.83906889 |
| 135 | Acute hepatic failure (HP:0006554) | 1.82384606 |
| 136 | Skin rash (HP:0000988) | 1.78108805 |
| 137 | Abnormality of the pericardium (HP:0001697) | 1.77414072 |
| 138 | Abnormality of the fingertips (HP:0001211) | 1.77413694 |
| 139 | Increased CSF protein (HP:0002922) | 1.77167761 |
| 140 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.76495861 |
| 141 | Cheilitis (HP:0100825) | 1.73892198 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TGFBR2 | 3.72893381 |
| 2 | MAP3K14 | 3.56444423 |
| 3 | MAP4K1 | 3.47866815 |
| 4 | BLK | 3.29204414 |
| 5 | MAP3K10 | 3.27101049 |
| 6 | TXK | 2.84334917 |
| 7 | IRAK4 | 2.76183462 |
| 8 | STK10 | 2.60197142 |
| 9 | TYK2 | 2.40317377 |
| 10 | CSF1R | 2.30608356 |
| 11 | IKBKE | 2.28605004 |
| 12 | KIT | 2.16476507 |
| 13 | GRK7 | 2.09252528 |
| 14 | RIPK4 | 2.08454743 |
| 15 | BTK | 2.05910229 |
| 16 | PIK3CG | 2.01881284 |
| 17 | TBK1 | 1.99921968 |
| 18 | IKBKB | 1.93621451 |
| 19 | IRAK1 | 1.82204869 |
| 20 | TEC | 1.72734762 |
| 21 | ZAP70 | 1.71303538 |
| 22 | CLK1 | 1.70593049 |
| 23 | HCK | 1.68660826 |
| 24 | EPHB1 | 1.66524429 |
| 25 | ITK | 1.60863681 |
| 26 | EIF2AK2 | 1.60850429 |
| 27 | TGFBR1 | 1.56057608 |
| 28 | CHUK | 1.55535371 |
| 29 | JAK3 | 1.55205948 |
| 30 | SYK | 1.54384288 |
| 31 | IRAK3 | 1.50687492 |
| 32 | MAP3K2 | 1.43780964 |
| 33 | TNK2 | 1.41130163 |
| 34 | MAP3K3 | 1.37933572 |
| 35 | FLT3 | 1.37701438 |
| 36 | LCK | 1.35682261 |
| 37 | JAK1 | 1.33461556 |
| 38 | LYN | 1.31974137 |
| 39 | PIM1 | 1.26717786 |
| 40 | KSR2 | 1.26095615 |
| 41 | CDK8 | 1.25872784 |
| 42 | BMPR2 | 1.25143352 |
| 43 | CSK | 1.22124740 |
| 44 | BMPR1B | 1.17144546 |
| 45 | FGFR3 | 1.08267530 |
| 46 | MAP3K1 | 1.07902776 |
| 47 | PINK1 | 1.07286801 |
| 48 | PIM2 | 1.05499645 |
| 49 | MAPK15 | 1.05232558 |
| 50 | IRAK2 | 1.03216743 |
| 51 | TAOK3 | 1.03130598 |
| 52 | SIK3 | 1.02067501 |
| 53 | MAP3K13 | 1.01849931 |
| 54 | MAP3K11 | 0.98972546 |
| 55 | MATK | 0.98732234 |
| 56 | MAPKAPK2 | 0.98667623 |
| 57 | YES1 | 0.96848970 |
| 58 | PTK2B | 0.96161562 |
| 59 | TAOK1 | 0.96025438 |
| 60 | FRK | 0.95370269 |
| 61 | GRK6 | 0.94884814 |
| 62 | CDK9 | 0.93869992 |
| 63 | WNK1 | 0.89544410 |
| 64 | MOS | 0.87337478 |
| 65 | JAK2 | 0.84904316 |
| 66 | NEK9 | 0.82582265 |
| 67 | LRRK2 | 0.81077517 |
| 68 | CAMKK2 | 0.80779820 |
| 69 | EEF2K | 0.77740956 |
| 70 | FES | 0.75541920 |
| 71 | DAPK2 | 0.74038130 |
| 72 | ACVR1B | 0.73573291 |
| 73 | NLK | 0.71852142 |
| 74 | MAPK7 | 0.69953595 |
| 75 | GRK5 | 0.69098551 |
| 76 | ERN1 | 0.67043038 |
| 77 | MST4 | 0.66623239 |
| 78 | TSSK6 | 0.65603425 |
| 79 | MAP3K5 | 0.65199626 |
| 80 | FGFR4 | 0.64994757 |
| 81 | ADRBK2 | 0.64984338 |
| 82 | RAF1 | 0.64726129 |
| 83 | EPHA3 | 0.62897958 |
| 84 | CDK7 | 0.59925543 |
| 85 | HIPK2 | 0.58031340 |
| 86 | MARK2 | 0.56688428 |
| 87 | PRPF4B | 0.56281505 |
| 88 | MAP2K3 | 0.55441179 |
| 89 | PRKD2 | 0.54440819 |
| 90 | ADRBK1 | 0.53007577 |
| 91 | MARK3 | 0.52400271 |
| 92 | PDPK1 | 0.51537131 |
| 93 | PRKCD | 0.50130111 |
| 94 | BRD4 | 0.48616966 |
| 95 | TRPM7 | 0.48094476 |
| 96 | RPS6KA4 | 0.47358546 |
| 97 | RPS6KL1 | 0.46527966 |
| 98 | RPS6KC1 | 0.46527966 |
| 99 | PRKCQ | 0.46451107 |
| 100 | RPS6KA6 | 0.46251111 |
| 101 | SIK2 | 0.46068362 |
| 102 | STK11 | 0.44337663 |
| 103 | MAPK4 | 0.43841429 |
| 104 | MAP2K6 | 0.42924392 |
| 105 | CDK3 | 0.41993412 |
| 106 | MAP3K7 | 0.41291109 |
| 107 | MAP3K6 | 0.41031272 |
| 108 | KSR1 | 0.40751169 |
| 109 | EGFR | 0.40267426 |
| 110 | IGF1R | 0.39693967 |
| 111 | CDK12 | 0.39335709 |
| 112 | CDK6 | 0.38984488 |
| 113 | SGK2 | 0.37384065 |
| 114 | STK38 | 0.37358522 |
| 115 | PAK4 | 0.37194693 |
| 116 | SGK3 | 0.37169254 |
| 117 | MKNK1 | 0.37063668 |
| 118 | CDK4 | 0.36118515 |
| 119 | ABL1 | 0.35050109 |
| 120 | RPS6KA2 | 0.34407804 |
| 121 | RET | 0.33637933 |
| 122 | MAPKAPK5 | 0.32690155 |
| 123 | CDC42BPA | 0.32317414 |
| 124 | CAMK4 | 0.31981252 |
| 125 | FYN | 0.31630110 |
| 126 | STK4 | 0.31322252 |
| 127 | PTK6 | 0.29946174 |
| 128 | MAPK12 | 0.29867751 |
| 129 | MELK | 0.29866026 |
| 130 | VRK1 | 0.29775428 |
| 131 | CAMKK1 | 0.29116698 |
| 132 | ERBB3 | 0.28730359 |
| 133 | FGR | 0.28479777 |
| 134 | PDK1 | 0.25885238 |
| 135 | MAPK3 | 0.25844469 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 2.98980784 |
| 2 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.95080005 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.87313400 |
| 4 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.67959917 |
| 5 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.60314036 |
| 6 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.55853956 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.51934499 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.29908921 |
| 9 | Measles_Homo sapiens_hsa05162 | 2.28528122 |
| 10 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.26203199 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.18716082 |
| 12 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.14105986 |
| 13 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.10779380 |
| 14 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.07886359 |
| 15 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.06108318 |
| 16 | Legionellosis_Homo sapiens_hsa05134 | 2.06059070 |
| 17 | Other glycan degradation_Homo sapiens_hsa00511 | 1.85413621 |
| 18 | Tuberculosis_Homo sapiens_hsa05152 | 1.76782934 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.76702500 |
| 20 | Malaria_Homo sapiens_hsa05144 | 1.76346306 |
| 21 | Pertussis_Homo sapiens_hsa05133 | 1.71400513 |
| 22 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.65846408 |
| 23 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.64371289 |
| 24 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.63430261 |
| 25 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.59472632 |
| 26 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.58083383 |
| 27 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.54735432 |
| 28 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.54193850 |
| 29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.52588984 |
| 30 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.49185672 |
| 31 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.46456462 |
| 32 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.45571172 |
| 33 | Influenza A_Homo sapiens_hsa05164 | 1.45426272 |
| 34 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.43561917 |
| 35 | Lysosome_Homo sapiens_hsa04142 | 1.41668188 |
| 36 | Apoptosis_Homo sapiens_hsa04210 | 1.34945220 |
| 37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.32780983 |
| 38 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.32673708 |
| 39 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.28959733 |
| 40 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.26322365 |
| 41 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.26166449 |
| 42 | Salmonella infection_Homo sapiens_hsa05132 | 1.24176797 |
| 43 | Hepatitis B_Homo sapiens_hsa05161 | 1.21984281 |
| 44 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.19716568 |
| 45 | Phagosome_Homo sapiens_hsa04145 | 1.19322300 |
| 46 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.16779112 |
| 47 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.16772012 |
| 48 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.15907461 |
| 49 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.15720549 |
| 50 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.11948034 |
| 51 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.06332588 |
| 52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.05074790 |
| 53 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.02918541 |
| 54 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.01023329 |
| 55 | Shigellosis_Homo sapiens_hsa05131 | 0.98521404 |
| 56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.97155104 |
| 57 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.96154614 |
| 58 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.93210674 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90669232 |
| 60 | Viral myocarditis_Homo sapiens_hsa05416 | 0.87573581 |
| 61 | Platelet activation_Homo sapiens_hsa04611 | 0.85707874 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.78185549 |
| 63 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.76544369 |
| 64 | HTLV-I infection_Homo sapiens_hsa05166 | 0.75858008 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.74540004 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.73933008 |
| 67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.70837859 |
| 68 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.70251123 |
| 69 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.70198977 |
| 70 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.69053413 |
| 71 | Hepatitis C_Homo sapiens_hsa05160 | 0.67106567 |
| 72 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.61262163 |
| 73 | Amoebiasis_Homo sapiens_hsa05146 | 0.60239861 |
| 74 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.59187719 |
| 75 | Colorectal cancer_Homo sapiens_hsa05210 | 0.58553606 |
| 76 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.54157592 |
| 77 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54104720 |
| 78 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.52954612 |
| 79 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.52282164 |
| 80 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.48864054 |
| 81 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.48646775 |
| 82 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.48617912 |
| 83 | Mismatch repair_Homo sapiens_hsa03430 | 0.47813193 |
| 84 | Prion diseases_Homo sapiens_hsa05020 | 0.47735146 |
| 85 | Insulin resistance_Homo sapiens_hsa04931 | 0.47396218 |
| 86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.46557542 |
| 87 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.45536258 |
| 88 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.43417594 |
| 89 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.42488994 |
| 90 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.41893502 |
| 91 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.39824216 |
| 92 | Endocytosis_Homo sapiens_hsa04144 | 0.37847199 |
| 93 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.37747577 |
| 94 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.37497846 |
| 95 | Olfactory transduction_Homo sapiens_hsa04740 | 0.37406619 |
| 96 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.37390595 |
| 97 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.37078397 |
| 98 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36583750 |
| 99 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33193335 |
| 100 | Morphine addiction_Homo sapiens_hsa05032 | 0.32855176 |
| 101 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.32567695 |
| 102 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.32149889 |
| 103 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.31809836 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.31444549 |
| 105 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.31371884 |
| 106 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.30701041 |
| 107 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.29635746 |
| 108 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29211228 |
| 109 | Base excision repair_Homo sapiens_hsa03410 | 0.28951102 |
| 110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.28907750 |
| 111 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.28875881 |
| 112 | Pathways in cancer_Homo sapiens_hsa05200 | 0.27759083 |
| 113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.25837611 |
| 114 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.25425969 |
| 115 | Homologous recombination_Homo sapiens_hsa03440 | 0.24297080 |
| 116 | Endometrial cancer_Homo sapiens_hsa05213 | 0.23692443 |
| 117 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.23592102 |
| 118 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.23501492 |
| 119 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.23353118 |
| 120 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.22426638 |
| 121 | Prostate cancer_Homo sapiens_hsa05215 | 0.21833961 |
| 122 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.17898374 |
| 123 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.16638444 |

