CAST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20795046
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.11520353
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.11520353
4hemidesmosome assembly (GO:0031581)3.95098666
5antigen processing and presentation of endogenous antigen (GO:0019883)3.68183710
6low-density lipoprotein particle clearance (GO:0034383)3.37116717
7desmosome organization (GO:0002934)3.29798027
8iron ion import (GO:0097286)3.26075799
9protein localization to endosome (GO:0036010)3.14332779
10cell adhesion mediated by integrin (GO:0033627)3.13279940
11regulation of interleukin-12 biosynthetic process (GO:0045075)3.09973581
12skin morphogenesis (GO:0043589)3.08264703
13barbed-end actin filament capping (GO:0051016)2.98130708
14negative regulation of complement activation (GO:0045916)2.95378487
15bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94101267
16endodermal cell differentiation (GO:0035987)2.93543029
17positive regulation of gamma-delta T cell activation (GO:0046645)2.92996180
18positive regulation of natural killer cell differentiation (GO:0032825)2.91259352
19surfactant homeostasis (GO:0043129)2.85774584
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79750551
21apoptotic cell clearance (GO:0043277)2.78526726
22negative regulation of humoral immune response (GO:0002921)2.78096611
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70340392
24membrane raft organization (GO:0031579)2.70337977
25regulation of T cell tolerance induction (GO:0002664)2.70135046
26plasma membrane repair (GO:0001778)2.70105312
27hepatocyte apoptotic process (GO:0097284)2.69720537
28regulation of cholesterol storage (GO:0010885)2.66802658
29macroautophagy (GO:0016236)2.66247724
30regulation of water loss via skin (GO:0033561)2.64551298
31leukocyte aggregation (GO:0070486)2.64516756
32negative regulation of protein activation cascade (GO:2000258)2.64119418
33skeletal muscle adaptation (GO:0043501)2.61784915
34positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61123511
35regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61057283
36cell-substrate junction assembly (GO:0007044)2.59645989
37positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59630305
38Golgi transport vesicle coating (GO:0048200)2.58526327
39COPI coating of Golgi vesicle (GO:0048205)2.58526327
40positive regulation of receptor recycling (GO:0001921)2.58012760
41striated muscle atrophy (GO:0014891)2.58009325
42Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56577146
43regulation of metalloenzyme activity (GO:0048552)2.56371430
44negative regulation of protein localization to plasma membrane (GO:1903077)2.54806861
45regulation of transforming growth factor beta1 production (GO:0032908)2.53880844
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53719480
47keratinocyte proliferation (GO:0043616)2.53652813
48establishment of skin barrier (GO:0061436)2.53306933
49growth hormone receptor signaling pathway (GO:0060396)2.51461307
50regulation of natural killer cell differentiation (GO:0032823)2.51365830
51regulation of necroptotic process (GO:0060544)2.49568769
52positive regulation of p38MAPK cascade (GO:1900745)2.44860648
53vascular endothelial growth factor signaling pathway (GO:0038084)2.44110492
54wound healing, spreading of epidermal cells (GO:0035313)2.44038969
55neutrophil activation involved in immune response (GO:0002283)2.43377798
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43026602
57regulation of gamma-delta T cell differentiation (GO:0045586)2.42323713
58regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42068986
59cellular response to thyroid hormone stimulus (GO:0097067)2.41699022
60positive regulation of interferon-alpha production (GO:0032727)2.40473745
61regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40321310
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.39717583
63negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.38520672
64cellular response to interferon-alpha (GO:0035457)2.38023019
65cellular response to epinephrine stimulus (GO:0071872)2.35314092
66collagen fibril organization (GO:0030199)2.34967379
67cytoskeletal anchoring at plasma membrane (GO:0007016)2.34841799
68regulation of extracellular matrix disassembly (GO:0010715)2.34564865
69regulation of sequestering of triglyceride (GO:0010889)2.34077592
70regulation of response to interferon-gamma (GO:0060330)2.33670904
71cell-substrate adherens junction assembly (GO:0007045)2.33642613
72focal adhesion assembly (GO:0048041)2.33642613
73negative regulation of anoikis (GO:2000811)2.33175305
74negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.32957542
75response to epinephrine (GO:0071871)2.31212031
76response to laminar fluid shear stress (GO:0034616)2.30887411
77regulation of interferon-alpha production (GO:0032647)2.28991114
78pinocytosis (GO:0006907)2.28733931
79positive regulation of tolerance induction (GO:0002645)2.28525141
80membrane protein ectodomain proteolysis (GO:0006509)2.26786790
81peptide catabolic process (GO:0043171)2.26765889
82epithelial cell-cell adhesion (GO:0090136)2.26531154
83regulation of gamma-delta T cell activation (GO:0046643)2.26445674
84peptide cross-linking (GO:0018149)2.26288904
85negative regulation of fatty acid transport (GO:2000192)2.26224605
86stress fiber assembly (GO:0043149)2.25875046
87negative regulation of lipid storage (GO:0010888)2.24712766
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.24592484
89embryonic process involved in female pregnancy (GO:0060136)2.23714798
90negative regulation of protein autophosphorylation (GO:0031953)2.23598834
91detection of other organism (GO:0098543)2.23533165
92JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.23514020
93COPII vesicle coating (GO:0048208)2.23205787
94regulation of early endosome to late endosome transport (GO:2000641)2.23164779
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.21878284
96actin filament-based movement (GO:0030048)2.21643835
97renal filtration (GO:0097205)2.21299515
98leukocyte cell-cell adhesion (GO:0007159)2.21042834
99actin-mediated cell contraction (GO:0070252)2.19756957
100multicellular organismal water homeostasis (GO:0050891)2.19491867
101positive regulation of endothelial cell apoptotic process (GO:2000353)2.19357873
102regulation of tolerance induction (GO:0002643)2.19267051
103mesodermal cell differentiation (GO:0048333)2.19101981
104fibril organization (GO:0097435)2.18267929
105regulation of interferon-beta biosynthetic process (GO:0045357)2.17781925
106positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17411428
107regulation of anoikis (GO:2000209)2.17132539
108sarcomere organization (GO:0045214)2.15910402
109muscle atrophy (GO:0014889)2.15751451
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.15284083
111cellular response to growth hormone stimulus (GO:0071378)2.11646332
112positive regulation of lipid storage (GO:0010884)2.10790392
113negative regulation of necroptotic process (GO:0060546)2.10696937
114antigen processing and presentation via MHC class Ib (GO:0002475)2.10587606
115integrin-mediated signaling pathway (GO:0007229)2.10343165
116detection of bacterium (GO:0016045)2.09469182
117regulation of tight junction assembly (GO:2000810)2.09401413
118tyrosine phosphorylation of STAT protein (GO:0007260)2.08893573
119positive thymic T cell selection (GO:0045059)2.08473937
120regulation of necrotic cell death (GO:0010939)2.07835172
121negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.07553691
122negative thymic T cell selection (GO:0045060)2.07232869
123fibroblast migration (GO:0010761)2.06904769
124response to thyroid hormone (GO:0097066)2.06488983
125positive regulation by symbiont of host defense response (GO:0052509)2.06181411
126modulation by symbiont of host defense response (GO:0052031)2.06181411
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.06181411
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.06181411
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.06181411
130modulation by symbiont of host immune response (GO:0052553)2.06181411
131keratinization (GO:0031424)2.05716354
132negative T cell selection (GO:0043383)2.05338607
133negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.05034435
134cellular extravasation (GO:0045123)2.04814116
135keratan sulfate catabolic process (GO:0042340)2.04794476
136chemical homeostasis within a tissue (GO:0048875)2.04548418
137muscle filament sliding (GO:0030049)2.03701223
138actin-myosin filament sliding (GO:0033275)2.03701223
139angiogenesis involved in wound healing (GO:0060055)2.03697501
140response to interferon-alpha (GO:0035455)2.03649164
141adherens junction assembly (GO:0034333)2.03599670
142response to type I interferon (GO:0034340)2.03586508
143import into cell (GO:0098657)2.03466515
144positive regulation of macrophage differentiation (GO:0045651)2.03253223
145regulation of transforming growth factor beta2 production (GO:0032909)2.02641462
146heterotypic cell-cell adhesion (GO:0034113)2.02384157
147hypotonic response (GO:0006971)2.02366555
148platelet-derived growth factor receptor signaling pathway (GO:0048008)2.02283934
149actomyosin structure organization (GO:0031032)2.02269901
150interferon-gamma-mediated signaling pathway (GO:0060333)2.02185537
151regulation of integrin activation (GO:0033623)2.01908769
152ventricular cardiac muscle cell action potential (GO:0086005)2.01478806
153negative regulation of interleukin-12 production (GO:0032695)2.01425174
154establishment of endothelial barrier (GO:0061028)2.01392842
155positive regulation of reactive oxygen species metabolic process (GO:2000379)2.00853092
156glomerular epithelial cell development (GO:0072310)2.00184814
157basement membrane organization (GO:0071711)2.00114260
158keratinocyte differentiation (GO:0030216)2.00102803
159protein hydroxylation (GO:0018126)1.99466566
160fatty acid transmembrane transport (GO:1902001)1.99267389
161natural killer cell mediated cytotoxicity (GO:0042267)1.99128913
162natural killer cell mediated immunity (GO:0002228)1.99128913
163cellular response to arsenic-containing substance (GO:0071243)1.98455141
164valine metabolic process (GO:0006573)1.98081947
165positive regulation of extracellular matrix organization (GO:1903055)1.97684955
166regulation of B cell receptor signaling pathway (GO:0050855)1.97599432
167actin filament depolymerization (GO:0030042)1.97135018
168extracellular fibril organization (GO:0043206)1.95362177
169carnitine transmembrane transport (GO:1902603)1.95350217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.51204622
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.67597979
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.53440334
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13955257
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06315266
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95580884
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91203451
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78929471
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59979356
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.58666646
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.55269939
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.50407354
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.45540763
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.43089005
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30795266
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18857018
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13086332
18CLOCK_20551151_ChIP-Seq_293T_Human2.09339622
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08266812
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07863546
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06388273
22* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02066499
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01430463
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98813507
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97116343
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91271988
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82794239
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82439201
29* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82198479
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82115077
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78423017
32* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75771149
33* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75771149
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75682447
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68824409
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65239396
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.63331559
38* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61723175
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61687432
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.58681787
41MYB_26560356_Chip-Seq_TH2_Human1.57913512
42MAF_26560356_Chip-Seq_TH1_Human1.57139851
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57139449
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.56554367
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55974236
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54953089
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54474462
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.54030856
49RUNX_20019798_ChIP-Seq_JUKART_Human1.52626249
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51643427
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50261839
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.50065377
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.47026289
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45664551
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.44664426
56CJUN_26792858_Chip-Seq_BT549_Human1.43105838
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40016418
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34913537
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.31836183
60TP63_23658742_ChIP-Seq_EP156T_Human1.31426610
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31258942
62MYB_26560356_Chip-Seq_TH1_Human1.29261847
63ATF3_27146783_Chip-Seq_COLON_Human1.27840748
64SOX2_20726797_ChIP-Seq_SW620_Human1.25241936
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24456815
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24116155
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23674240
68UTX_26944678_Chip-Seq_JUKART_Human1.23208000
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22758729
70VDR_24763502_ChIP-Seq_THP-1_Human1.22442645
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21040765
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20553716
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20521372
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20331951
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.19349772
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18974559
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.18545993
78VDR_21846776_ChIP-Seq_THP-1_Human1.18074907
79TCF7_22412390_ChIP-Seq_EML_Mouse1.17040476
80GATA1_19941826_ChIP-Seq_K562_Human1.16905442
81AHR_22903824_ChIP-Seq_MCF-7_Human1.16784100
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.14694822
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.14694822
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14677472
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14465958
86* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14190070
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.13837040
88* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13502766
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12999410
90PU_27001747_Chip-Seq_BMDM_Mouse1.12503610
91SPI1_23547873_ChIP-Seq_NB4_Human1.12497996
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12301675
93VDR_24787735_ChIP-Seq_THP-1_Human1.11896184
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11328854
95GATA4_25053715_ChIP-Seq_YYC3_Human1.11252115
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10550820
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08815794
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08792210
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08748053
100SPI1_23127762_ChIP-Seq_K562_Human1.05585857
101FOXA2_19822575_ChIP-Seq_HepG2_Human1.05546873
102ZNF263_19887448_ChIP-Seq_K562_Human1.05435439
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04872174
104TP53_16413492_ChIP-PET_HCT116_Human1.04762369
105GATA1_22025678_ChIP-Seq_K562_Human1.02729599
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02289790
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02289790
108* GATA6_25053715_ChIP-Seq_YYC3_Human1.02113530
109GATA3_27048872_Chip-Seq_THYMUS_Human1.01745820
110BRD4_25478319_ChIP-Seq_HGPS_Human1.01556588
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.01319354
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01033968
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00521089
114RACK7_27058665_Chip-Seq_MCF-7_Human1.00442647
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.00195379
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99094968
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98801774
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98465838
119* KLF5_25053715_ChIP-Seq_YYC3_Human0.98119418
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.97953104
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97900196
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97328099
123SCL_19346495_ChIP-Seq_HPC-7_Human0.96555843
124GATA2_19941826_ChIP-Seq_K562_Human0.95949582
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94229736
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94052618
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92603107
128MYC_22102868_ChIP-Seq_BL_Human0.91115034
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91049855
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90085950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.54202655
2MP0005275_abnormal_skin_tensile3.25163754
3MP0003705_abnormal_hypodermis_morpholog3.15073688
4MP0003566_abnormal_cell_adhesion2.44647178
5MP0010352_gastrointestinal_tract_polyps2.11664841
6MP0003436_decreased_susceptibility_to2.09223940
7MP0005451_abnormal_body_composition1.97285749
8MP0003300_gastrointestinal_ulcer1.93652347
9MP0001835_abnormal_antigen_presentation1.92829376
10MP0002166_altered_tumor_susceptibility1.83637542
11MP0004947_skin_inflammation1.82967064
12MP0002060_abnormal_skin_morphology1.82723383
13MP0005023_abnormal_wound_healing1.79798515
14MP0003279_aneurysm1.79766825
15MP0010234_abnormal_vibrissa_follicle1.77712737
16MP0009785_altered_susceptibility_to1.76429957
17MP0006054_spinal_hemorrhage1.69683410
18MP0000685_abnormal_immune_system1.66106935
19MP0000751_myopathy1.61281491
20MP0002796_impaired_skin_barrier1.60889475
21MP0004036_abnormal_muscle_relaxation1.60045296
22MP0009780_abnormal_chondrocyte_physiolo1.59334132
23MP0005409_darkened_coat_color1.54687323
24MP0002006_tumorigenesis1.48756336
25MP0005330_cardiomyopathy1.46464494
26MP0010155_abnormal_intestine_physiology1.45089584
27MP0002877_abnormal_melanocyte_morpholog1.44596119
28MP0003191_abnormal_cellular_cholesterol1.44408081
29MP0005165_increased_susceptibility_to1.42608803
30MP0000343_altered_response_to1.39201600
31MP0001533_abnormal_skeleton_physiology1.39053673
32MP0003724_increased_susceptibility_to1.38976810
33MP0010678_abnormal_skin_adnexa1.38523619
34MP0003453_abnormal_keratinocyte_physiol1.38280159
35MP0005164_abnormal_response_to1.37683323
36MP0001873_stomach_inflammation1.37032096
37MP0006138_congestive_heart_failure1.36334368
38MP0005000_abnormal_immune_tolerance1.35520913
39MP0002419_abnormal_innate_immunity1.35286379
40MP0001958_emphysema1.35091656
41MP0005025_abnormal_response_to1.33678723
42MP0003303_peritoneal_inflammation1.32483005
43MP0004272_abnormal_basement_membrane1.32043694
44MP0002148_abnormal_hypersensitivity_rea1.31345629
45MP0005671_abnormal_response_to1.31306404
46MP0001790_abnormal_immune_system1.30973166
47MP0005387_immune_system_phenotype1.30973166
48MP0003091_abnormal_cell_migration1.29283622
49MP0003448_altered_tumor_morphology1.28104514
50MP0000013_abnormal_adipose_tissue1.27792960
51MP0008260_abnormal_autophagy1.27388090
52MP0004185_abnormal_adipocyte_glucose1.26379204
53MP0002405_respiratory_system_inflammati1.26232005
54MP0004084_abnormal_cardiac_muscle1.25756577
55MP0002452_abnormal_antigen_presenting1.25165772
56MP0002933_joint_inflammation1.25028632
57MP0005503_abnormal_tendon_morphology1.24404204
58MP0003656_abnormal_erythrocyte_physiolo1.23547529
59MP0000858_altered_metastatic_potential1.22320726
60MP0001800_abnormal_humoral_immune1.21195011
61MP0004484_altered_response_of1.21172060
62MP0003828_pulmonary_edema1.19236382
63MP0004264_abnormal_extraembryonic_tissu1.18286947
64MP0005076_abnormal_cell_differentiation1.17994513
65MP0005670_abnormal_white_adipose1.17160170
66MP0001243_abnormal_dermal_layer1.16966303
67MP0003045_fibrosis1.16847943
68MP0004130_abnormal_muscle_cell1.16265225
69MP0006082_CNS_inflammation1.15402882
70MP0002332_abnormal_exercise_endurance1.13715827
71MP0000579_abnormal_nail_morphology1.13528199
72MP0005501_abnormal_skin_physiology1.13398403
73MP0001851_eye_inflammation1.13359239
74MP0001216_abnormal_epidermal_layer1.13211836
75MP0002896_abnormal_bone_mineralization1.11945410
76MP0000003_abnormal_adipose_tissue1.11166280
77MP0008004_abnormal_stomach_pH1.10737746
78MP0005257_abnormal_intraocular_pressure1.10631110
79MP0005375_adipose_tissue_phenotype1.10041472
80MP0005464_abnormal_platelet_physiology1.09026853
81MP0005666_abnormal_adipose_tissue1.08696966
82MP0002254_reproductive_system_inflammat1.07967591
83MP0001819_abnormal_immune_cell1.07136926
84MP0002420_abnormal_adaptive_immunity1.07074979
85MP0002723_abnormal_immune_serum1.06784238
86MP0003763_abnormal_thymus_physiology1.06560541
87MP0001845_abnormal_inflammatory_respons1.06167601
88MP0001853_heart_inflammation1.05579316
89MP0004215_abnormal_myocardial_fiber1.05059101
90MP0002972_abnormal_cardiac_muscle1.03910958
91MP0001849_ear_inflammation1.03598445
92MP0000733_abnormal_muscle_development1.02027488
93MP0009333_abnormal_splenocyte_physiolog1.00000332
94MP0005397_hematopoietic_system_phenotyp0.99547049
95MP0001545_abnormal_hematopoietic_system0.99547049
96MP0005166_decreased_susceptibility_to0.98627257
97MP0004510_myositis0.98462621
98MP0002998_abnormal_bone_remodeling0.98419977
99MP0005058_abnormal_lysosome_morphology0.96295500
100MP0000749_muscle_degeneration0.96141130
101MP0009384_cardiac_valve_regurgitation0.95623188
102MP0010368_abnormal_lymphatic_system0.95579807
103MP0000750_abnormal_muscle_regeneration0.93561591
104MP0004087_abnormal_muscle_fiber0.92432577
105MP0010307_abnormal_tumor_latency0.90894460
106MP0010630_abnormal_cardiac_muscle0.90853678
107MP0009840_abnormal_foam_cell0.90227067
108MP0004808_abnormal_hematopoietic_stem0.89816879
109MP0004883_abnormal_blood_vessel0.89776410
110MP0002269_muscular_atrophy0.88849578
111MP0005390_skeleton_phenotype0.87901588
112MP0003941_abnormal_skin_development0.87629297
113MP0000249_abnormal_blood_vessel0.87628092
114MP0003950_abnormal_plasma_membrane0.87048321
115MP0003183_abnormal_peptide_metabolism0.86625385
116MP0000467_abnormal_esophagus_morphology0.86115709
117MP0000767_abnormal_smooth_muscle0.85638584
118MP0000759_abnormal_skeletal_muscle0.85138009
119MP0008469_abnormal_protein_level0.84223229
120MP0009278_abnormal_bone_marrow0.83610289
121MP0008775_abnormal_heart_ventricle0.82181576
122MP0000383_abnormal_hair_follicle0.82009012
123MP0000465_gastrointestinal_hemorrhage0.81385489
124MP0001879_abnormal_lymphatic_vessel0.81308746
125MP0002398_abnormal_bone_marrow0.80799231
126MP0004233_abnormal_muscle_weight0.80587311
127MP0002837_dystrophic_cardiac_calcinosis0.79368306
128MP0009931_abnormal_skin_appearance0.79363654
129MP0005623_abnormal_meninges_morphology0.79174914
130MP0000716_abnormal_immune_system0.78337115
131MP0000762_abnormal_tongue_morphology0.77790890
132MP0003075_altered_response_to0.77783924
133MP0002971_abnormal_brown_adipose0.77412007
134MP0000747_muscle_weakness0.77386703
135MP0009764_decreased_sensitivity_to0.77198481
136MP0001191_abnormal_skin_condition0.76727621
137MP0005360_urolithiasis0.76691526
138MP0001544_abnormal_cardiovascular_syste0.76437457
139MP0005385_cardiovascular_system_phenoty0.76437457
140MP0003186_abnormal_redox_activity0.75838901

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.86805770
2Protrusio acetabuli (HP:0003179)3.77953814
3Increased connective tissue (HP:0009025)3.72079077
4Premature rupture of membranes (HP:0001788)3.51822141
5Eczematoid dermatitis (HP:0000976)3.46907943
6Pustule (HP:0200039)3.41817465
7Atrophic scars (HP:0001075)3.24331336
8Osteolytic defects of the hand bones (HP:0009699)3.08960359
9Osteolytic defects of the phalanges of the hand (HP:0009771)3.08960359
10Peritonitis (HP:0002586)3.03409162
11Vascular tortuosity (HP:0004948)2.98362876
12Arterial tortuosity (HP:0005116)2.97541918
13Aortic dissection (HP:0002647)2.94685494
14Alopecia of scalp (HP:0002293)2.94621055
15Cervical subluxation (HP:0003308)2.93309551
16Aortic aneurysm (HP:0004942)2.83239325
17Type 1 muscle fiber predominance (HP:0003803)2.70867564
18Hyporeflexia of lower limbs (HP:0002600)2.70316695
19Ankle contracture (HP:0006466)2.70196344
20Myocardial infarction (HP:0001658)2.69672603
21Cerebral aneurysm (HP:0004944)2.68673312
22Autoimmune thrombocytopenia (HP:0001973)2.64387639
23Ventricular tachycardia (HP:0004756)2.63333946
24Thick nail (HP:0001805)2.62684650
25Recurrent abscess formation (HP:0002722)2.62056840
26Myositis (HP:0100614)2.52832657
27Fragile skin (HP:0001030)2.52767134
28Nasal polyposis (HP:0100582)2.51041051
29Exercise-induced myalgia (HP:0003738)2.46472170
30Abnormality of the nasal mucosa (HP:0000433)2.44728338
31Broad metatarsal (HP:0001783)2.43986611
32Exercise-induced muscle cramps (HP:0003710)2.42562463
33Vertebral compression fractures (HP:0002953)2.41339791
34Milia (HP:0001056)2.35600998
35Distal lower limb muscle weakness (HP:0009053)2.35164729
36Dilatation of the ascending aorta (HP:0005111)2.32085097
37Bundle branch block (HP:0011710)2.31413379
38Malnutrition (HP:0004395)2.31117805
39Elevated erythrocyte sedimentation rate (HP:0003565)2.30074542
40Increased mean platelet volume (HP:0011877)2.28318851
41Abnormality of nail color (HP:0100643)2.26508028
42Spondylolisthesis (HP:0003302)2.23232248
43Recurrent gram-negative bacterial infections (HP:0005420)2.22849003
44Recurrent bacterial skin infections (HP:0005406)2.21934884
45Orchitis (HP:0100796)2.21248631
46Abnormal platelet volume (HP:0011876)2.19070812
47Increased variability in muscle fiber diameter (HP:0003557)2.18190301
48Muscle fiber splitting (HP:0003555)2.17201983
49Difficulty climbing stairs (HP:0003551)2.16545543
50Increased IgE level (HP:0003212)2.15194833
51Cardiovascular calcification (HP:0011915)2.15036705
52Hematochezia (HP:0002573)2.12360683
53Facial diplegia (HP:0001349)2.07590369
54Abnormality of liposaccharide metabolism (HP:0010968)2.06131009
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.06131009
56Abnormality of glycolipid metabolism (HP:0010969)2.06131009
57Plantar hyperkeratosis (HP:0007556)2.05085103
58Flat acetabular roof (HP:0003180)2.04524217
59Asymmetric septal hypertrophy (HP:0001670)2.04090080
60Mitral valve prolapse (HP:0001634)2.03907140
61Mitral stenosis (HP:0001718)2.03792819
62Glucose intolerance (HP:0000833)2.02846696
63Lipoatrophy (HP:0100578)2.00216245
64Cupped ribs (HP:0000887)1.99030636
65Follicular hyperkeratosis (HP:0007502)1.98761809
66Interstitial pulmonary disease (HP:0006530)1.98102040
67Natal tooth (HP:0000695)1.97655962
68Centrally nucleated skeletal muscle fibers (HP:0003687)1.97345126
69Spinal rigidity (HP:0003306)1.95943365
70Increased density of long bones (HP:0006392)1.95634872
71Neck muscle weakness (HP:0000467)1.95627288
72Recurrent fungal infections (HP:0002841)1.94918852
73Vascular calcification (HP:0004934)1.94096012
74Distal lower limb amyotrophy (HP:0008944)1.93878151
75Nemaline bodies (HP:0003798)1.92913186
76Arterial thrombosis (HP:0004420)1.92646660
77Frequent falls (HP:0002359)1.91550062
78Onycholysis (HP:0001806)1.90710125
79Nail dystrophy (HP:0008404)1.88561348
80Periodontitis (HP:0000704)1.88069222
81Shallow orbits (HP:0000586)1.87191190
82EMG: myopathic abnormalities (HP:0003458)1.84922174
83Abnormal blistering of the skin (HP:0008066)1.84880606
84Difficulty running (HP:0009046)1.84799678
85Mildly elevated creatine phosphokinase (HP:0008180)1.84640750
86Polycythemia (HP:0001901)1.83635991
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83442062
88Radial bowing (HP:0002986)1.83291616
89Aneurysm (HP:0002617)1.82459702
90Ventricular arrhythmia (HP:0004308)1.81655852
91Reduced subcutaneous adipose tissue (HP:0003758)1.79696572
92Muscle fiber inclusion bodies (HP:0100299)1.78466401
93Advanced eruption of teeth (HP:0006288)1.78418712
94Ridged nail (HP:0001807)1.77584833
95Fragile nails (HP:0001808)1.77498726
96Broad face (HP:0000283)1.77348377
97Amyloidosis (HP:0011034)1.77015252
98Gingivitis (HP:0000230)1.76135982
99Nonimmune hydrops fetalis (HP:0001790)1.75988900
100Palmoplantar hyperkeratosis (HP:0000972)1.75670697
101Abnormal foot bone ossification (HP:0010675)1.74772828
102Absent frontal sinuses (HP:0002688)1.74126428
103Rhabdomyolysis (HP:0003201)1.74081661
104Conjunctival hamartoma (HP:0100780)1.73093516
105Axonal loss (HP:0003447)1.72604232
106Ankyloglossia (HP:0010296)1.72476716
107Mucopolysacchariduria (HP:0008155)1.72473649
108Urinary glycosaminoglycan excretion (HP:0003541)1.72473649
109Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71766529
110Ulnar deviation of the wrist (HP:0003049)1.70840538
111Hypoplasia of dental enamel (HP:0006297)1.70762151
112Woolly hair (HP:0002224)1.70649787
113Hydroxyprolinuria (HP:0003080)1.70601113
114Abnormality of proline metabolism (HP:0010907)1.70601113
115Atrial fibrillation (HP:0005110)1.70598525
116Short nail (HP:0001799)1.70330384
117Abnormal glucose tolerance (HP:0001952)1.70261216
118Blue sclerae (HP:0000592)1.69811233
119Myoglobinuria (HP:0002913)1.69569307
120Coarse hair (HP:0002208)1.68040355
121Abnormality of macrophages (HP:0004311)1.67606767
122Soft skin (HP:0000977)1.67438528
123Skin ulcer (HP:0200042)1.67262772
124Abnormality of skeletal muscle fiber size (HP:0012084)1.67050421
125Recurrent bronchitis (HP:0002837)1.66703350
126Subacute progressive viral hepatitis (HP:0006572)1.66678540
127Gastrointestinal infarctions (HP:0005244)1.66371558
128Abnormality of T cell number (HP:0011839)1.66019429
129Elbow flexion contracture (HP:0002987)1.65364757
130Wormian bones (HP:0002645)1.64732802
131Ulnar bowing (HP:0003031)1.64601238
132Acanthosis nigricans (HP:0000956)1.64304235
133Slender build (HP:0001533)1.64039274
134Abnormality of oral frenula (HP:0000190)1.63968641
135Esophageal varix (HP:0002040)1.63222020
136Dilated cardiomyopathy (HP:0001644)1.62918577
137Abnormality of the distal phalanges of the toes (HP:0010182)1.62648008
138Hyperactive renin-angiotensin system (HP:0000841)1.62606731
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62464302
140Abnormality of polysaccharide metabolism (HP:0011012)1.62464302
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62464302
142Retrobulbar optic neuritis (HP:0100654)1.62342854
143Optic neuritis (HP:0100653)1.62342854
144Abnormality of the calf musculature (HP:0001430)1.61609154
145Tetraparesis (HP:0002273)1.61604069
146Abnormality of complement system (HP:0005339)1.61440745
147Sudden death (HP:0001699)1.60951300
148Palmar hyperkeratosis (HP:0010765)1.60902974
149Nephritis (HP:0000123)1.59350828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.54658923
2TRIB32.84505772
3ERN12.28717049
4PKN22.27795929
5MAP4K12.07791083
6STK102.04055553
7NEK92.00584069
8TRPM71.90398730
9TYK21.89625763
10MAP3K21.85568700
11RIPK11.82117468
12TBK11.80818560
13JAK31.79168753
14MAP3K141.76916298
15LRRK21.72382128
16MAP3K31.69222788
17PRPF4B1.68775673
18FGFR41.68572616
19PDK41.67607096
20PDK31.67607096
21TESK11.63050001
22CDC42BPA1.62750489
23JAK11.62432926
24MST1R1.60455873
25TGFBR21.54632881
26PIK3CA1.42834333
27FGFR31.42401546
28TXK1.41654469
29MAP2K31.38883931
30ZAP701.34768302
31MST41.34497307
32PDK21.33978734
33MAP3K131.30908989
34PIM21.27914337
35LATS11.27009703
36FRK1.26418847
37EPHB11.24433857
38PTK61.23487162
39STK381.23005340
40MAPKAPK31.22353690
41RPS6KA41.22337063
42EPHA21.21502672
43DDR21.18435286
44LMTK21.17723084
45IKBKE1.17065349
46PDGFRA1.16831126
47NME21.16064123
48ITK1.15428738
49CSK1.14259604
50MAP3K61.13899208
51FLT31.10553443
52SIK11.10069345
53EPHA31.07232775
54MOS1.06147092
55STK31.04281373
56KIT1.03687893
57CAMK1D1.02935212
58KSR21.00948028
59MYLK1.00263008
60SCYL20.99865835
61MAP3K100.99751435
62EEF2K0.99430038
63MAP3K10.96266542
64KDR0.95966206
65TGFBR10.94192417
66PRKG20.94114454
67IKBKB0.93777943
68ICK0.93673705
69BLK0.93535837
70BMPR20.93401925
71CDK60.90529565
72PRKAA20.88472277
73PIM10.84862593
74BMX0.83401085
75DMPK0.80182876
76STK240.79281481
77OBSCN0.78163785
78PDPK10.77267262
79LATS20.77151181
80TEC0.77145615
81FER0.76957916
82PIK3CG0.76326502
83MARK30.76290349
84PDGFRB0.74534304
85PTK2B0.74439533
86HCK0.74241030
87MAP3K120.73056433
88PTK20.70662998
89PAK40.70582520
90CSF1R0.70523646
91CHUK0.70307033
92MAPK70.69562706
93MAPK110.68447728
94ARAF0.68358059
95STK40.67450167
96LCK0.66911800
97JAK20.64452354
98RIPK40.62601739
99CDK120.60757063
100RPS6KB20.60030646
101ROCK10.60021662
102MAPK120.59849949
103MELK0.59239449
104IRAK40.58670422
105PRKD20.57518394
106EPHB20.56743669
107PAK20.56340288
108BTK0.55823679
109AKT30.55320976
110FGFR10.54934223
111SGK30.54892525
112WNK10.54818413
113STK38L0.51752271
114MAP3K50.51678607
115MAP3K80.50546535
116ROCK20.50516009
117MAPKAPK20.49720321
118IRAK30.48734302
119PRKD10.48662171
120NUAK10.47239477
121MARK20.47189438
122RET0.45833763
123MET0.45731771
124ILK0.45479686
125PDK10.45280544
126GRK70.45186347
127MAP3K110.44764113
128ERBB30.42107555
129TAOK10.41846339
130NEK60.41344427
131HIPK20.41125468
132GRK60.40776111
133TAOK30.40232118
134MAP2K10.39905779
135MTOR0.39401068
136NLK0.39070918
137MAP3K70.38977850
138ERBB40.38858334
139ABL10.38109586
140BCKDK0.37763357
141ACVR1B0.37548701

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.26423192
2Leishmaniasis_Homo sapiens_hsa051402.18194767
3Malaria_Homo sapiens_hsa051441.92192832
4Staphylococcus aureus infection_Homo sapiens_hsa051501.85975650
5Toxoplasmosis_Homo sapiens_hsa051451.79149758
6ECM-receptor interaction_Homo sapiens_hsa045121.78413407
7Viral myocarditis_Homo sapiens_hsa054161.77404177
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71442492
9Osteoclast differentiation_Homo sapiens_hsa043801.64371032
10Leukocyte transendothelial migration_Homo sapiens_hsa046701.62059460
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.61112388
12Legionellosis_Homo sapiens_hsa051341.56993598
13Antigen processing and presentation_Homo sapiens_hsa046121.56136028
14Measles_Homo sapiens_hsa051621.51846251
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48798663
16Focal adhesion_Homo sapiens_hsa045101.45945505
17Graft-versus-host disease_Homo sapiens_hsa053321.45331717
18Small cell lung cancer_Homo sapiens_hsa052221.40133716
19Adherens junction_Homo sapiens_hsa045201.37870872
20PPAR signaling pathway_Homo sapiens_hsa033201.36887226
21Amoebiasis_Homo sapiens_hsa051461.36602403
22Fatty acid degradation_Homo sapiens_hsa000711.31420076
23Hematopoietic cell lineage_Homo sapiens_hsa046401.30862285
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.30845932
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.29716118
26TNF signaling pathway_Homo sapiens_hsa046681.28423345
27Apoptosis_Homo sapiens_hsa042101.27392887
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25977312
29Allograft rejection_Homo sapiens_hsa053301.25830776
30Salmonella infection_Homo sapiens_hsa051321.24898906
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23864935
32Shigellosis_Homo sapiens_hsa051311.23273069
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22315714
34Pertussis_Homo sapiens_hsa051331.21452839
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18700111
36Proteoglycans in cancer_Homo sapiens_hsa052051.17901236
37Primary immunodeficiency_Homo sapiens_hsa053401.15574684
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14134644
39Tuberculosis_Homo sapiens_hsa051521.11862047
40Renal cell carcinoma_Homo sapiens_hsa052111.11692605
41Complement and coagulation cascades_Homo sapiens_hsa046101.08619938
42Circadian rhythm_Homo sapiens_hsa047101.07941337
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.07311625
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06512745
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06219291
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02994078
47Influenza A_Homo sapiens_hsa051640.99700225
48Chronic myeloid leukemia_Homo sapiens_hsa052200.98711304
49Insulin resistance_Homo sapiens_hsa049310.98337182
50Platelet activation_Homo sapiens_hsa046110.97202595
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94739525
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94628774
53Starch and sucrose metabolism_Homo sapiens_hsa005000.94434540
54B cell receptor signaling pathway_Homo sapiens_hsa046620.90495053
55Acute myeloid leukemia_Homo sapiens_hsa052210.89877263
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89870673
57T cell receptor signaling pathway_Homo sapiens_hsa046600.88595263
58Sphingolipid metabolism_Homo sapiens_hsa006000.88476989
59Insulin signaling pathway_Homo sapiens_hsa049100.87157272
60VEGF signaling pathway_Homo sapiens_hsa043700.86697250
61Histidine metabolism_Homo sapiens_hsa003400.86631711
62Non-small cell lung cancer_Homo sapiens_hsa052230.85884888
63GnRH signaling pathway_Homo sapiens_hsa049120.85460226
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85205871
65Herpes simplex infection_Homo sapiens_hsa051680.84646737
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84248056
67Propanoate metabolism_Homo sapiens_hsa006400.83627105
68HIF-1 signaling pathway_Homo sapiens_hsa040660.83028615
69Mineral absorption_Homo sapiens_hsa049780.82750200
70p53 signaling pathway_Homo sapiens_hsa041150.82711557
71Pancreatic cancer_Homo sapiens_hsa052120.82701925
72Dilated cardiomyopathy_Homo sapiens_hsa054140.82666230
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79334183
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78693129
75Hepatitis C_Homo sapiens_hsa051600.78257513
76Phagosome_Homo sapiens_hsa041450.78019260
77Hepatitis B_Homo sapiens_hsa051610.77886634
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77714443
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.77692778
80Endocytosis_Homo sapiens_hsa041440.77342768
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76763494
82Dorso-ventral axis formation_Homo sapiens_hsa043200.76331201
83Renin-angiotensin system_Homo sapiens_hsa046140.76106072
84Fat digestion and absorption_Homo sapiens_hsa049750.75989196
85Carbon metabolism_Homo sapiens_hsa012000.74024624
86Fructose and mannose metabolism_Homo sapiens_hsa000510.73661185
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72916431
88Renin secretion_Homo sapiens_hsa049240.72598354
89Lysosome_Homo sapiens_hsa041420.72276838
90Pentose phosphate pathway_Homo sapiens_hsa000300.70109876
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69897269
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69697854
93Protein digestion and absorption_Homo sapiens_hsa049740.69672803
94Endometrial cancer_Homo sapiens_hsa052130.69137602
95Inositol phosphate metabolism_Homo sapiens_hsa005620.68916150
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68722006
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68354634
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67730622
99Phenylalanine metabolism_Homo sapiens_hsa003600.67493852
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67171463
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66689778
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66292140
103Tight junction_Homo sapiens_hsa045300.66058845
104Bladder cancer_Homo sapiens_hsa052190.65879928
105Other glycan degradation_Homo sapiens_hsa005110.65544934
106Prolactin signaling pathway_Homo sapiens_hsa049170.64619015
107Fatty acid metabolism_Homo sapiens_hsa012120.63716566
108Sulfur metabolism_Homo sapiens_hsa009200.63136562
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62743349
110Viral carcinogenesis_Homo sapiens_hsa052030.62547833
111Arginine biosynthesis_Homo sapiens_hsa002200.61643382
112Fatty acid biosynthesis_Homo sapiens_hsa000610.60950115
113FoxO signaling pathway_Homo sapiens_hsa040680.60659676
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.59920356
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59917755
116Chemical carcinogenesis_Homo sapiens_hsa052040.59209940
117mTOR signaling pathway_Homo sapiens_hsa041500.58958478
118Pancreatic secretion_Homo sapiens_hsa049720.58760143
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.58280672
120MicroRNAs in cancer_Homo sapiens_hsa052060.56942838
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.56627964
122Autoimmune thyroid disease_Homo sapiens_hsa053200.56145023
123Galactose metabolism_Homo sapiens_hsa000520.55998945
124Thyroid cancer_Homo sapiens_hsa052160.55268258
125Prostate cancer_Homo sapiens_hsa052150.54893247
126HTLV-I infection_Homo sapiens_hsa051660.53940747
127Tryptophan metabolism_Homo sapiens_hsa003800.53598425
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.53536560
129Rheumatoid arthritis_Homo sapiens_hsa053230.52082078
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51324354
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50315001
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50005173

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