CASZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.78589706
2regulation of rhodopsin mediated signaling pathway (GO:0022400)6.69790391
3rhodopsin mediated signaling pathway (GO:0016056)6.54541594
4establishment of skin barrier (GO:0061436)6.50751914
5regulation of water loss via skin (GO:0033561)6.27366123
6photoreceptor cell maintenance (GO:0045494)5.77451044
7retinal cone cell development (GO:0046549)5.31281401
8photoreceptor cell development (GO:0042461)5.26264996
9detection of light stimulus involved in visual perception (GO:0050908)5.15812392
10detection of light stimulus involved in sensory perception (GO:0050962)5.15812392
11eye photoreceptor cell development (GO:0042462)5.10952941
12hemidesmosome assembly (GO:0031581)4.95435416
13ventricular cardiac muscle cell action potential (GO:0086005)4.83828868
14keratinocyte proliferation (GO:0043616)4.76726723
15keratinization (GO:0031424)4.75821137
16multicellular organismal water homeostasis (GO:0050891)4.61539796
17cell communication involved in cardiac conduction (GO:0086065)4.39464895
18cilium or flagellum-dependent cell motility (GO:0001539)4.33896499
19sarcomere organization (GO:0045214)4.29399353
20detection of visible light (GO:0009584)4.26157741
21eye photoreceptor cell differentiation (GO:0001754)4.22895179
22photoreceptor cell differentiation (GO:0046530)4.22895179
23phototransduction (GO:0007602)4.21496262
24phototransduction, visible light (GO:0007603)4.21434925
25hair cycle (GO:0042633)4.21335397
26molting cycle (GO:0042303)4.21335397
27detection of light stimulus (GO:0009583)4.21068934
28axonemal dynein complex assembly (GO:0070286)4.14973069
29retinal rod cell development (GO:0046548)4.08101433
30intermediate filament organization (GO:0045109)4.07543710
31motile cilium assembly (GO:0044458)3.94819044
32keratinocyte differentiation (GO:0030216)3.91458626
33endothelial cell chemotaxis (GO:0035767)3.86319187
34regulation of cardioblast differentiation (GO:0051890)3.84461079
35visual perception (GO:0007601)3.82156462
36regulation of heart rate by cardiac conduction (GO:0086091)3.81938728
37sensory perception of light stimulus (GO:0050953)3.81763354
38muscle filament sliding (GO:0030049)3.80215172
39actin-myosin filament sliding (GO:0033275)3.80215172
40peptide cross-linking (GO:0018149)3.71027582
41negative regulation of keratinocyte proliferation (GO:0010839)3.69020749
42actin-mediated cell contraction (GO:0070252)3.67200642
43skeletal muscle contraction (GO:0003009)3.64389807
44positive regulation of guanylate cyclase activity (GO:0031284)3.63030425
45water homeostasis (GO:0030104)3.61720759
46cardiac conduction (GO:0061337)3.57981485
47plasma membrane repair (GO:0001778)3.56532820
48cardiac myofibril assembly (GO:0055003)3.53242832
49sphingoid metabolic process (GO:0046519)3.51941571
50regulation of skeletal muscle contraction (GO:0014819)3.51560983
51epidermal cell differentiation (GO:0009913)3.50776710
52epithelial cell differentiation involved in prostate gland development (GO:0060742)3.47902401
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.41317753
54myofibril assembly (GO:0030239)3.36903445
55atrioventricular valve morphogenesis (GO:0003181)3.34543505
56cardiac muscle contraction (GO:0060048)3.33408062
57regulation of guanylate cyclase activity (GO:0031282)3.33236125
58protein-chromophore linkage (GO:0018298)3.30866274
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.29469149
60GMP metabolic process (GO:0046037)3.28454294
61cardiac right ventricle morphogenesis (GO:0003215)3.23980577
62carnitine transmembrane transport (GO:1902603)3.23337210
63negative regulation of potassium ion transmembrane transport (GO:1901380)3.20474476
64carnitine shuttle (GO:0006853)3.18204074
65cardiac muscle cell action potential (GO:0086001)3.17446422
66regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17121617
67cilium movement (GO:0003341)3.14064960
68cardiac muscle cell action potential involved in contraction (GO:0086002)3.09274616
69adult heart development (GO:0007512)3.08760731
70negative regulation of myotube differentiation (GO:0010832)3.07677983
71detection of external stimulus (GO:0009581)3.05725183
72epidermis development (GO:0008544)3.04997776
73ectoderm development (GO:0007398)3.04620930
74response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.03517872
75retina development in camera-type eye (GO:0060041)3.02299017
76quaternary ammonium group transport (GO:0015697)3.02289656
77carnitine transport (GO:0015879)3.02245470
78amino-acid betaine transport (GO:0015838)3.02245470
79insulin-like growth factor receptor signaling pathway (GO:0048009)3.01613110
80positive regulation of fatty acid beta-oxidation (GO:0032000)3.00171684
81striated muscle atrophy (GO:0014891)2.99170466
82sphingosine metabolic process (GO:0006670)2.98607110
83intestinal epithelial cell development (GO:0060576)2.98068930
84detection of abiotic stimulus (GO:0009582)2.97961103
85cardiac muscle tissue morphogenesis (GO:0055008)2.97936056
86actin filament-based movement (GO:0030048)2.97760130
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97756443
88phospholipid scrambling (GO:0017121)2.97584859
89response to inactivity (GO:0014854)2.97129396
90striated muscle contraction (GO:0006941)2.96026019
91ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.91989523
92hair cell differentiation (GO:0035315)2.91501106
93epithelial cell-cell adhesion (GO:0090136)2.90473003
94diol metabolic process (GO:0034311)2.90361346
95regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90212877
96regulation of relaxation of muscle (GO:1901077)2.86439391
97histone H3-K36 demethylation (GO:0070544)2.86245265
98relaxation of cardiac muscle (GO:0055119)2.86066469
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85732022
100skeletal muscle adaptation (GO:0043501)2.83804210
101cardiac muscle cell development (GO:0055013)2.81825952
102actomyosin structure organization (GO:0031032)2.81413842
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80248144
104regulation of fatty acid beta-oxidation (GO:0031998)2.80176808
105muscle tissue morphogenesis (GO:0060415)2.79635749
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78643426
107cardiac cell development (GO:0055006)2.77641814
108keratinocyte development (GO:0003334)2.76866449
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75656893
110chemical homeostasis within a tissue (GO:0048875)2.72579213
111apical protein localization (GO:0045176)2.71355673
112intermediate filament cytoskeleton organization (GO:0045104)2.68361797
113regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67647758
114regulation of actin filament-based movement (GO:1903115)2.67444148
115intermediate filament-based process (GO:0045103)2.67358427
116surfactant homeostasis (GO:0043129)2.67320064
117cell junction maintenance (GO:0034331)2.65141259
118negative regulation of fatty acid transport (GO:2000192)2.64629902
119striated muscle adaptation (GO:0014888)2.64297141
120sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63471368
121regulation of phospholipase A2 activity (GO:0032429)2.61965137
122receptor guanylyl cyclase signaling pathway (GO:0007168)2.59942203
123cell-cell junction maintenance (GO:0045217)2.58926985
124cellular response to light stimulus (GO:0071482)2.57276610
125fatty acid transmembrane transport (GO:1902001)2.56346775
126establishment of planar polarity (GO:0001736)2.55054369
127establishment of tissue polarity (GO:0007164)2.55054369
128regulation of heart rate (GO:0002027)2.53906278
129outflow tract septum morphogenesis (GO:0003148)2.53885241
130muscle atrophy (GO:0014889)2.53714315
131linoleic acid metabolic process (GO:0043651)2.52767509
132regulation of fatty acid oxidation (GO:0046320)2.49403610
133glandular epithelial cell differentiation (GO:0002067)2.48186173
134positive regulation of histone deacetylation (GO:0031065)2.45357868
135positive regulation of fatty acid oxidation (GO:0046321)2.45299921
136calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.43964210
137creatine metabolic process (GO:0006600)2.40997220
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.36352417
139regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.36071415
140cardiac muscle hypertrophy (GO:0003300)2.35954201
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.35732620
142lung epithelium development (GO:0060428)2.35644174
143left/right pattern formation (GO:0060972)2.33880876
144syncytium formation by plasma membrane fusion (GO:0000768)2.32524857
145ear development (GO:0043583)2.30807920
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28029152
147semaphorin-plexin signaling pathway (GO:0071526)2.27579327
148negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27186396
149asymmetric protein localization (GO:0008105)2.26097835
150positive regulation of keratinocyte differentiation (GO:0045618)2.25398738
151regulation of keratinocyte differentiation (GO:0045616)2.24359584
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23489782
153peptidyl-tyrosine autophosphorylation (GO:0038083)2.22250607
154myoblast fusion (GO:0007520)2.21786981
155positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.19589022
156striated muscle hypertrophy (GO:0014897)2.19322922
157phosphatidylserine acyl-chain remodeling (GO:0036150)2.19192905
158desmosome organization (GO:0002934)10.3945098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.52091445
2* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.55081889
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43975975
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.11042029
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.01388656
6TP63_17297297_ChIP-ChIP_HaCaT_Human10.3064798
7CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95207649
8ESR1_21235772_ChIP-Seq_MCF-7_Human1.95064900
9EZH2_22144423_ChIP-Seq_EOC_Human1.94193232
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.92472186
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90068575
12P63_26484246_Chip-Seq_KERATINOCYTES_Human1.86393554
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85956714
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80218096
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.73843334
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69520181
17CDX2_20551321_ChIP-Seq_CACO-2_Human1.68248717
18* TCF4_18268006_ChIP-ChIP_LS174T_Human1.63749829
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62107951
20AHR_22903824_ChIP-Seq_MCF-7_Human1.60187727
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58918302
22ZNF263_19887448_ChIP-Seq_K562_Human1.56666697
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56476338
24* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56316621
25* RUNX1_27514584_Chip-Seq_MCF-7_Human1.54931510
26VDR_22108803_ChIP-Seq_LS180_Human1.52054725
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50486851
28TCF7_22412390_ChIP-Seq_EML_Mouse1.48658117
29* CREB1_26743006_Chip-Seq_LNCaP_Human1.47999995
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.47470993
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.47470993
32KDM2B_26808549_Chip-Seq_DND41_Human1.42696049
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.41397052
34* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41361625
35* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41361625
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40795042
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38085307
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36435817
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.36268160
40* SMC4_20622854_ChIP-Seq_HELA_Human1.36035359
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.35078327
42KLF5_25053715_ChIP-Seq_YYC3_Human1.33778570
43SOX2_20726797_ChIP-Seq_SW620_Human1.29694218
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28953099
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27966639
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.22392006
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21824356
48* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21522876
49CJUN_26792858_Chip-Seq_BT549_Human1.20039125
50* TP63_22573176_ChIP-Seq_HFKS_Human1.19804347
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19488236
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.18063770
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17232292
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.16639427
55* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16524418
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.15763932
57* TP63_23658742_ChIP-Seq_EP156T_Human1.15683583
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.15678144
59* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14989549
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14844816
61* CTCF_27219007_Chip-Seq_Bcells_Human1.14376762
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13038659
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12193585
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.11833794
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11305372
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11218757
67* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10224971
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09371357
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.09290142
70GATA4_25053715_ChIP-Seq_YYC3_Human1.08940689
71DROSHA_22980978_ChIP-Seq_HELA_Human1.08597100
72* P68_20966046_ChIP-Seq_HELA_Human1.07718221
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05596138
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05317877
75* BCAT_22108803_ChIP-Seq_LS180_Human1.03936659
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03857979
77* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03241492
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.02770216
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.02563217
80* KDM2B_26808549_Chip-Seq_K562_Human1.01988922
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.00852361
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00648309
83GATA1_19941826_ChIP-Seq_K562_Human1.00123047
84RXR_22158963_ChIP-Seq_LIVER_Mouse0.99612386
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98956914
86* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97952155
87EGR1_19032775_ChIP-ChIP_M12_Human0.97414607
88* RNF2_27304074_Chip-Seq_ESCs_Mouse0.97089704
89AR_21572438_ChIP-Seq_LNCaP_Human0.96823694
90* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96412021
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96354780
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96085602
93* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95687515
94* EZH2_27304074_Chip-Seq_ESCs_Mouse0.95291945
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94869018
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94375785
97* RACK7_27058665_Chip-Seq_MCF-7_Human0.94215246
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.93685035
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.91771803
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91017856
101* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89370623
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88828055
103* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88620527
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88259806
105* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86582420
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86582381
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86198887
108VDR_21846776_ChIP-Seq_THP-1_Human0.86160601
109RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84582836
110EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84582836
111* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84346775
112* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84335870
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83036007
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80852565
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80027057
116* TCF4_22108803_ChIP-Seq_LS180_Human0.79797487
117* ATF3_27146783_Chip-Seq_COLON_Human0.79454228
118* UBF1/2_26484160_Chip-Seq_HMECs_Human0.78741765
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.77936880
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77038929
121NANOG_20526341_ChIP-Seq_ESCs_Human0.73741366
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73257649
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73233668
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73124561
125RXR_22108803_ChIP-Seq_LS180_Human0.72482601
126* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72197157
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72093204
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.71941548
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71767087
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70318976
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69825155
132TP53_16413492_ChIP-PET_HCT116_Human0.68906182
133* LXR_22292898_ChIP-Seq_THP-1_Human0.68009538
134* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.67510125
135* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67427471
136* RBPJ_21746931_ChIP-Seq_IB4_Human0.67160456
137GATA1_22025678_ChIP-Seq_K562_Human0.66548057
138GATA2_19941826_ChIP-Seq_K562_Human0.66439441
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.66333545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.05083211
2MP0003011_delayed_dark_adaptation4.66828772
3MP0003941_abnormal_skin_development4.31635760
4MP0010234_abnormal_vibrissa_follicle4.30670260
5MP0005551_abnormal_eye_electrophysiolog4.20623253
6MP0006072_abnormal_retinal_apoptosis3.60486703
7MP0000579_abnormal_nail_morphology3.26661848
8MP0005253_abnormal_eye_physiology3.06478866
9MP0005275_abnormal_skin_tensile3.00123978
10MP0002098_abnormal_vibrissa_morphology2.96904831
11MP0005501_abnormal_skin_physiology2.91211050
12MP0003950_abnormal_plasma_membrane2.68295296
13MP0002254_reproductive_system_inflammat2.61741292
14MP0002822_catalepsy2.33928711
15MP0004084_abnormal_cardiac_muscle2.28222572
16MP0002837_dystrophic_cardiac_calcinosis2.26607295
17MP0009780_abnormal_chondrocyte_physiolo2.18309458
18MP0002249_abnormal_larynx_morphology2.18282578
19MP0002060_abnormal_skin_morphology2.15972776
20MP0001216_abnormal_epidermal_layer2.15735002
21MP0004858_abnormal_nervous_system2.14363254
22MP0004510_myositis2.09200418
23MP0004381_abnormal_hair_follicle2.06555798
24MP0005670_abnormal_white_adipose2.06409445
25MP0005076_abnormal_cell_differentiation2.06095256
26MP0001346_abnormal_lacrimal_gland2.02643140
27MP0000751_myopathy2.02241714
28MP0000566_synostosis2.01648264
29MP0004215_abnormal_myocardial_fiber1.92380863
30MP0010678_abnormal_skin_adnexa1.90635307
31MP0000383_abnormal_hair_follicle1.82704388
32MP0000647_abnormal_sebaceous_gland1.81426818
33MP0004036_abnormal_muscle_relaxation1.76634437
34MP0000377_abnormal_hair_follicle1.76417751
35MP0003646_muscle_fatigue1.75015341
36MP0010771_integument_phenotype1.74875094
37MP0000749_muscle_degeneration1.74578572
38MP0004043_abnormal_pH_regulation1.71564618
39MP0003453_abnormal_keratinocyte_physiol1.67381718
40MP0001324_abnormal_eye_pigmentation1.57411381
41MP0005330_cardiomyopathy1.55958394
42MP0004947_skin_inflammation1.55595078
43MP0003705_abnormal_hypodermis_morpholog1.52972620
44MP0003828_pulmonary_edema1.51609689
45MP0005451_abnormal_body_composition1.51222519
46MP0004130_abnormal_muscle_cell1.50582211
47MP0002638_abnormal_pupillary_reflex1.50450001
48MP0000467_abnormal_esophagus_morphology1.49715548
49MP0002009_preneoplasia1.49459552
50MP0003566_abnormal_cell_adhesion1.48006790
51MP0005195_abnormal_posterior_eye1.47438383
52MP0002972_abnormal_cardiac_muscle1.46810094
53MP0000762_abnormal_tongue_morphology1.46438249
54MP0000427_abnormal_hair_cycle1.46380296
55MP0005666_abnormal_adipose_tissue1.41137977
56MP0002234_abnormal_pharynx_morphology1.40844818
57MP0003879_abnormal_hair_cell1.35252583
58MP0002090_abnormal_vision1.34648261
59MP0001765_abnormal_ion_homeostasis1.32548705
60MP0004233_abnormal_muscle_weight1.32423518
61MP0005391_vision/eye_phenotype1.29101871
62MP0000747_muscle_weakness1.28658179
63MP0001873_stomach_inflammation1.27983714
64MP0000733_abnormal_muscle_development1.26486816
65MP0005620_abnormal_muscle_contractility1.26187246
66MP0002653_abnormal_ependyma_morphology1.23408281
67MP0002108_abnormal_muscle_morphology1.22583030
68MP0000750_abnormal_muscle_regeneration1.19285132
69MP0002127_abnormal_cardiovascular_syste1.15567201
70MP0009379_abnormal_foot_pigmentation1.14924429
71MP0004087_abnormal_muscle_fiber1.14913232
72MP0001664_abnormal_digestion1.11426501
73MP0004782_abnormal_surfactant_physiolog1.10992369
74MP0010630_abnormal_cardiac_muscle1.08113648
75MP0005375_adipose_tissue_phenotype1.07606033
76MP0004264_abnormal_extraembryonic_tissu1.05916077
77MP0010386_abnormal_urinary_bladder1.05900761
78MP0000538_abnormal_urinary_bladder1.05353925
79MP0005310_abnormal_salivary_gland1.05251376
80MP0008775_abnormal_heart_ventricle1.03317544
81MP0003137_abnormal_impulse_conducting0.99357550
82MP0001544_abnormal_cardiovascular_syste0.97694168
83MP0005385_cardiovascular_system_phenoty0.97694168
84MP0001191_abnormal_skin_condition0.95216792
85MP0002332_abnormal_exercise_endurance0.93579335
86MP0005367_renal/urinary_system_phenotyp0.91649477
87MP0000516_abnormal_urinary_system0.91649477
88MP0004085_abnormal_heartbeat0.91058470
89MP0004484_altered_response_of0.90379431
90MP0009931_abnormal_skin_appearance0.89530300
91MP0006138_congestive_heart_failure0.89489613
92MP0002877_abnormal_melanocyte_morpholog0.88579934
93MP0001986_abnormal_taste_sensitivity0.87743968
94MP0004185_abnormal_adipocyte_glucose0.85824929
95MP0003878_abnormal_ear_physiology0.85534599
96MP0005377_hearing/vestibular/ear_phenot0.85534599
97MP0003045_fibrosis0.85246789
98MP0002106_abnormal_muscle_physiology0.85129441
99MP0010155_abnormal_intestine_physiology0.82803498
100MP0005187_abnormal_penis_morphology0.81873500
101MP0002971_abnormal_brown_adipose0.81065194
102MP0002269_muscular_atrophy0.79869954
103MP0000462_abnormal_digestive_system0.77365579
104MP0000613_abnormal_salivary_gland0.77304494
105MP0000367_abnormal_coat/_hair0.76642443
106MP0004145_abnormal_muscle_electrophysio0.74797224
107MP0000470_abnormal_stomach_morphology0.74649042
108MP0008004_abnormal_stomach_pH0.74113926
109MP0008789_abnormal_olfactory_epithelium0.73995611
110MP0002138_abnormal_hepatobiliary_system0.70952368
111MP0009643_abnormal_urine_homeostasis0.70672711
112MP0005369_muscle_phenotype0.69784118
113MP0000759_abnormal_skeletal_muscle0.69205704
114MP0002229_neurodegeneration0.67756432
115MP0003191_abnormal_cellular_cholesterol0.67668299
116MP0004019_abnormal_vitamin_homeostasis0.66597854
117MP0002168_other_aberrant_phenotype0.66285985
118MP0001666_abnormal_nutrient_absorption0.65309023
119MP0005409_darkened_coat_color0.65130088
120MP0002909_abnormal_adrenal_gland0.64743284
121MP0009115_abnormal_fat_cell0.64707619
122MP0003183_abnormal_peptide_metabolism0.64038522
123MP0001188_hyperpigmentation0.63788932
124MP0002752_abnormal_somatic_nervous0.63508165
125MP0005248_abnormal_Harderian_gland0.62506121
126MP0008961_abnormal_basal_metabolism0.62169590
127MP0000465_gastrointestinal_hemorrhage0.61607673
128MP0000537_abnormal_urethra_morphology0.60335385
129MP0002166_altered_tumor_susceptibility0.60002631
130MP0000678_abnormal_parathyroid_gland0.58856760
131MP0001270_distended_abdomen0.57374585
132MP0002277_abnormal_respiratory_mucosa0.56926049
133MP0010030_abnormal_orbit_morphology0.56299837
134MP0001784_abnormal_fluid_regulation0.55520602
135MP0010352_gastrointestinal_tract_polyps0.54004153

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.82674699
2Absent rod-and cone-mediated responses on ERG (HP:0007688)7.14493407
3Bony spicule pigmentary retinopathy (HP:0007737)6.51875521
4Abnormal rod and cone electroretinograms (HP:0008323)6.36494780
5Right ventricular cardiomyopathy (HP:0011663)6.21985594
6Central scotoma (HP:0000603)6.02605472
7Pigmentary retinal degeneration (HP:0001146)5.61561117
8Pendular nystagmus (HP:0012043)5.06201168
9Chorioretinal atrophy (HP:0000533)4.98855706
10Scotoma (HP:0000575)4.73327175
11Ventricular tachycardia (HP:0004756)4.71554283
12Abnormality of macular pigmentation (HP:0008002)4.68669054
13Dyschromatopsia (HP:0007641)4.53711753
14Lip pit (HP:0100267)4.48232600
15Sudden death (HP:0001699)4.45864141
16Attenuation of retinal blood vessels (HP:0007843)4.37276264
17Abolished electroretinogram (ERG) (HP:0000550)4.22632562
18Woolly hair (HP:0002224)4.02032750
19Hyporeflexia of lower limbs (HP:0002600)3.99369978
20Decreased central vision (HP:0007663)3.96435862
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.85970888
22Hypotrichosis (HP:0001006)3.83582474
23Increased IgE level (HP:0003212)3.74900746
24Posterior subcapsular cataract (HP:0007787)3.70052669
25Abnormal respiratory epithelium morphology (HP:0012253)3.68925274
26Abnormal respiratory motile cilium morphology (HP:0005938)3.68925274
27Keratoconus (HP:0000563)3.66677416
28Increased corneal curvature (HP:0100692)3.66677416
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.60438596
30Absent/shortened dynein arms (HP:0200106)3.60438596
31Abnormality of the fingertips (HP:0001211)3.56700607
32Severe visual impairment (HP:0001141)3.50951666
33Macular degeneration (HP:0000608)3.44414922
34Syncope (HP:0001279)3.43370820
35Abnormal ciliary motility (HP:0012262)3.43155044
36Hyperkalemia (HP:0002153)3.40173698
37Abnormal respiratory motile cilium physiology (HP:0012261)3.35560272
38Obstructive sleep apnea (HP:0002870)3.27493344
39Ventricular fibrillation (HP:0001663)3.27293918
40Cone-rod dystrophy (HP:0000548)3.24864069
41Plantar hyperkeratosis (HP:0007556)3.21715164
42Chronic bronchitis (HP:0004469)3.20422308
43Rhinitis (HP:0012384)3.18526957
44Popliteal pterygium (HP:0009756)3.18420230
45Photophobia (HP:0000613)3.17524009
46Congenital sensorineural hearing impairment (HP:0008527)3.16706155
47Broad face (HP:0000283)3.15087826
48Type II diabetes mellitus (HP:0005978)3.11939371
49Calf muscle hypertrophy (HP:0008981)3.11349261
50Hyperactive renin-angiotensin system (HP:0000841)3.07768923
51Abnormality of secondary sexual hair (HP:0009888)3.06423764
52Abnormality of the axillary hair (HP:0100134)3.06423764
53Fragile nails (HP:0001808)3.02593503
54Nasal polyposis (HP:0100582)3.00749273
55Decreased circulating renin level (HP:0003351)2.99391963
56Pili torti (HP:0003777)2.92456440
57Muscle fiber inclusion bodies (HP:0100299)2.88408664
58Palmoplantar hyperkeratosis (HP:0000972)2.85686298
59Prolonged QT interval (HP:0001657)2.85566038
60Exercise-induced myalgia (HP:0003738)2.82827727
61Onycholysis (HP:0001806)2.82500745
62Muscle hypertrophy of the lower extremities (HP:0008968)2.78006309
63Atrial fibrillation (HP:0005110)2.75701851
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.74271769
65Abnormality of the calf musculature (HP:0001430)2.73933266
66Milia (HP:0001056)2.73338729
67Asymmetric septal hypertrophy (HP:0001670)2.68436789
68Palmar hyperkeratosis (HP:0010765)2.66820538
69Malnutrition (HP:0004395)2.66532238
70Abnormality of the nasal mucosa (HP:0000433)2.65875418
71Distal lower limb muscle weakness (HP:0009053)2.63305110
72Nemaline bodies (HP:0003798)2.62353985
73Primary atrial arrhythmia (HP:0001692)2.58440797
74Constricted visual fields (HP:0001133)2.56925099
75Congenital ichthyosiform erythroderma (HP:0007431)2.51632689
76Alopecia of scalp (HP:0002293)2.51090307
77Germ cell neoplasia (HP:0100728)2.50940382
78Depressed nasal tip (HP:0000437)2.50846731
79Myopathic facies (HP:0002058)2.48968371
80Subcapsular cataract (HP:0000523)2.47038863
81Abnormality of the dental root (HP:0006486)2.46110662
82Taurodontia (HP:0000679)2.46110662
83Abnormality of permanent molar morphology (HP:0011071)2.46110662
84Supraventricular tachycardia (HP:0004755)2.45911620
85Palmoplantar keratoderma (HP:0000982)2.45527123
86Muscle fiber splitting (HP:0003555)2.45170111
87Abnormality of nail color (HP:0100643)2.43769211
88Bronchiectasis (HP:0002110)2.43518239
89Supraventricular arrhythmia (HP:0005115)2.39007158
90Ulnar deviation of the wrist (HP:0003049)2.38341430
91Ventricular arrhythmia (HP:0004308)2.35874669
92EMG: neuropathic changes (HP:0003445)2.34056322
93Flat acetabular roof (HP:0003180)2.33302334
94Subaortic stenosis (HP:0001682)2.32914578
95Abnormality of the left ventricular outflow tract (HP:0011103)2.32914578
96Lipoatrophy (HP:0100578)2.29886243
97Vitreoretinal degeneration (HP:0000655)2.29613388
98Progressive visual loss (HP:0000529)2.28620057
99Laryngomalacia (HP:0001601)2.24919870
100Increased connective tissue (HP:0009025)2.24467272
101Palpitations (HP:0001962)2.24447136
102Curly hair (HP:0002212)2.23807120
103Neoplasm of the heart (HP:0100544)2.23499226
104Abnormality of molar (HP:0011077)2.22582955
105Abnormality of molar morphology (HP:0011070)2.22582955
106Natal tooth (HP:0000695)2.21629737
107Abnormality of the dental pulp (HP:0006479)2.20737800
108Congenital malformation of the right heart (HP:0011723)2.19403650
109Double outlet right ventricle (HP:0001719)2.19403650
110Dysmetric saccades (HP:0000641)2.17356202
111Exercise-induced muscle cramps (HP:0003710)2.15286424
112Retinitis pigmentosa (HP:0000510)2.14254044
113Advanced eruption of teeth (HP:0006288)2.12552731
114Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12180341
115Sparse lateral eyebrow (HP:0005338)2.12155617
116Parakeratosis (HP:0001036)2.10845918
117Bulbar palsy (HP:0001283)2.08602576
118Amelogenesis imperfecta (HP:0000705)2.06353219
119Abnormality of the gastric mucosa (HP:0004295)2.05572774
120Mildly elevated creatine phosphokinase (HP:0008180)2.03449907
121Sparse scalp hair (HP:0002209)2.02810383
122Choroideremia (HP:0001139)2.01989259
123Corneal erosion (HP:0200020)2.01299925
124Skin pits (HP:0100276)2.00768766
125Type 1 muscle fiber predominance (HP:0003803)1.98146630
126Aplasia of the musculature (HP:0100854)1.97988178
127Areflexia of lower limbs (HP:0002522)1.97426072
128Abnormal EKG (HP:0003115)1.96880359
129Aplasia cutis congenita (HP:0001057)1.96280053
130Erythema (HP:0010783)1.96249606
131Down-sloping shoulders (HP:0200021)1.95303933
132Round ear (HP:0100830)1.93206002
133Dilated cardiomyopathy (HP:0001644)1.92851310
134Difficulty running (HP:0009046)1.92522153
135Abnormal blistering of the skin (HP:0008066)1.92153088
136Hypoplastic labia majora (HP:0000059)1.91154934
137Atelectasis (HP:0100750)1.91073053
138Abnormality of the neuromuscular junction (HP:0003398)1.90102274
139Fatigable weakness (HP:0003473)1.90102274
140Hamartoma of the eye (HP:0010568)1.89815890
141Conjunctival hamartoma (HP:0100780)1.89468545
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.87733441
143Eczematoid dermatitis (HP:0000976)1.85662137
144Bronchomalacia (HP:0002780)1.85369704
145Abnormality of the aortic arch (HP:0012303)1.84725224
146Genetic anticipation (HP:0003743)1.84393702
147Bundle branch block (HP:0011710)1.83906913
148Bell-shaped thorax (HP:0001591)1.83874694
149EMG: myopathic abnormalities (HP:0003458)1.81556618
150Thin bony cortex (HP:0002753)1.81282430
151Neck muscle weakness (HP:0000467)1.78821328
152Abnormality of the labia majora (HP:0012881)1.78290304
153Distal arthrogryposis (HP:0005684)1.75742555
154Abnormality of the salivary glands (HP:0010286)1.74211927
155Nail dystrophy (HP:0008404)1.69891688
156Pterygium (HP:0001059)1.68248272
157Thick nail (HP:0001805)1.65322921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42181651
2GRK13.91835744
3MST43.19637906
4OBSCN3.17378407
5MAPK153.02485951
6EEF2K3.00506769
7SIK12.98026958
8LMTK22.82615287
9EPHB22.69126018
10TAOK32.64075672
11MAPKAPK32.64031960
12MST1R2.58103937
13STK242.38040789
14SMG12.28176897
15FER2.22398207
16INSRR2.21894797
17MYLK2.16115549
18PKN22.10999737
19AKT31.97586369
20DMPK1.96156168
21MARK21.93834952
22TTN1.92591072
23MAP3K31.86559233
24CAMK1D1.85514978
25ICK1.83229436
26BMPR1B1.74561611
27FRK1.71532967
28PHKG11.68917179
29PHKG21.68917179
30ERN11.63538895
31MAP3K21.63470886
32PRKD21.60532013
33PIK3CA1.57457819
34MAP3K61.42761521
35NME11.41082698
36ZAK1.38168414
37LATS11.37955762
38CAMK1G1.35204763
39RIPK11.33498595
40PIK3CG1.22324476
41HIPK21.22223447
42SIK21.19673643
43PINK11.18999181
44PRKD31.18494941
45EPHA31.17810830
46MTOR1.16221769
47MAP3K101.14870524
48TRPM71.13224689
49MAP2K21.11445298
50MAP3K71.11335311
51TIE11.09588216
52PTK61.09443027
53RPS6KB21.07362242
54TGFBR11.06694616
55WNK41.03347193
56PIM20.98082339
57BRD40.97636526
58CDC42BPA0.97298842
59EPHA20.91372289
60PRKD10.90647201
61CDK120.89216994
62MUSK0.87853506
63ROCK10.84795076
64EPHB10.83919258
65ERBB30.82391238
66DYRK1B0.81149790
67RPS6KA20.79548651
68PRKG20.78315542
69STK38L0.77910074
70MAP2K60.77540300
71PRKAA20.76436515
72ERBB20.76281561
73TBK10.75942260
74SGK4940.75447168
75SGK2230.75447168
76MAP3K10.75335102
77IRAK10.74792018
78MAP3K140.72587788
79CAMK2D0.71460931
80RPS6KL10.70448233
81RPS6KC10.70448233
82WNK10.65112603
83ADRBK10.64667062
84PRKCE0.64635882
85CHUK0.64359915
86NUAK10.63232518
87PRKCI0.62809737
88FGFR30.61025388
89CAMK40.60723113
90IKBKE0.60575180
91RET0.60321183
92MAPKAPK20.60196679
93NLK0.59626188
94TNK20.57217038
95STK390.57031843
96RPS6KA60.56805389
97LRRK20.55556849
98GRK70.54912197
99MAP2K30.53669764
100MAPK120.53644858
101PRKAA10.53403154
102CAMK10.53239456
103BCR0.50933043
104CDK90.49827124
105PDPK10.49099026
106TAOK10.47557167
107IRAK20.46128600
108IRAK30.45769508
109CDK30.45600183
110MAPK70.44376170
111PRPF4B0.42581591
112RPS6KA10.41598328
113STK380.41549154
114SGK20.41315426
115IRAK40.39684000
116PRKCZ0.39246967
117FGFR40.38198159
118SGK30.38038542
119STK110.37533231
120PRKACA0.37186713
121ITK0.36971171
122PDK20.36543288
123TEC0.36516685
124MAP2K10.35984666
125MAPK40.35939691
126DDR20.34460209
127MAP2K40.32968969
128PRKACG0.32633110
129MET0.32161867
130RPS6KB10.32058024
131PAK30.31980445
132NEK90.31858712
133MAPK110.31518987
134IKBKB0.31172257
135MAPK80.31163717
136CSNK1D0.30235893
137PKN10.29973785

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.53214311
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53835764
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.22017591
4Cardiac muscle contraction_Homo sapiens_hsa042602.20725569
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16933252
6Dilated cardiomyopathy_Homo sapiens_hsa054142.04173073
7Histidine metabolism_Homo sapiens_hsa003401.88866136
8Mineral absorption_Homo sapiens_hsa049781.74410970
9Fat digestion and absorption_Homo sapiens_hsa049751.68045376
10Fatty acid biosynthesis_Homo sapiens_hsa000611.59508687
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.50212395
12Sphingolipid metabolism_Homo sapiens_hsa006001.49648617
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40001143
14Tight junction_Homo sapiens_hsa045301.31985230
15Renin-angiotensin system_Homo sapiens_hsa046141.28900019
16Choline metabolism in cancer_Homo sapiens_hsa052311.22454875
17Protein digestion and absorption_Homo sapiens_hsa049741.18765251
18Circadian rhythm_Homo sapiens_hsa047101.15743462
19Galactose metabolism_Homo sapiens_hsa000521.14436402
20Starch and sucrose metabolism_Homo sapiens_hsa005001.13316383
21Adherens junction_Homo sapiens_hsa045201.12755818
22Ovarian steroidogenesis_Homo sapiens_hsa049131.11908119
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08580404
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07622162
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07407611
26PPAR signaling pathway_Homo sapiens_hsa033201.06107025
27Insulin secretion_Homo sapiens_hsa049111.05995352
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03650446
29ABC transporters_Homo sapiens_hsa020101.01752825
30Olfactory transduction_Homo sapiens_hsa047401.00426327
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00153231
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98334300
33Retinol metabolism_Homo sapiens_hsa008300.97903564
34Linoleic acid metabolism_Homo sapiens_hsa005910.95286066
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95084154
36mTOR signaling pathway_Homo sapiens_hsa041500.93805013
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92725671
38Renin secretion_Homo sapiens_hsa049240.91900456
39Pancreatic secretion_Homo sapiens_hsa049720.90777535
40Caffeine metabolism_Homo sapiens_hsa002320.90619205
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88715789
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87577050
43Prostate cancer_Homo sapiens_hsa052150.87050178
44Bile secretion_Homo sapiens_hsa049760.86397453
45Ether lipid metabolism_Homo sapiens_hsa005650.85085425
46Insulin resistance_Homo sapiens_hsa049310.83837421
47Oxidative phosphorylation_Homo sapiens_hsa001900.82962643
48Type II diabetes mellitus_Homo sapiens_hsa049300.82396392
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81393867
50Estrogen signaling pathway_Homo sapiens_hsa049150.79452421
51Alzheimers disease_Homo sapiens_hsa050100.77782245
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76148440
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75926319
54Chemical carcinogenesis_Homo sapiens_hsa052040.75168463
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.74632699
56Prolactin signaling pathway_Homo sapiens_hsa049170.74360136
57Basal cell carcinoma_Homo sapiens_hsa052170.73863319
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73099757
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72413016
60Renal cell carcinoma_Homo sapiens_hsa052110.71575209
61beta-Alanine metabolism_Homo sapiens_hsa004100.71376136
62TNF signaling pathway_Homo sapiens_hsa046680.70265078
63FoxO signaling pathway_Homo sapiens_hsa040680.68782792
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68056894
65Gastric acid secretion_Homo sapiens_hsa049710.67892985
66Oxytocin signaling pathway_Homo sapiens_hsa049210.66127097
67Arachidonic acid metabolism_Homo sapiens_hsa005900.66112847
68Cholinergic synapse_Homo sapiens_hsa047250.66045287
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.65193450
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64996917
71ECM-receptor interaction_Homo sapiens_hsa045120.64541072
72Arginine biosynthesis_Homo sapiens_hsa002200.64274940
73Lysine degradation_Homo sapiens_hsa003100.64247953
74ErbB signaling pathway_Homo sapiens_hsa040120.64219641
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62655000
76Tyrosine metabolism_Homo sapiens_hsa003500.62179751
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59808629
78Dorso-ventral axis formation_Homo sapiens_hsa043200.58463953
79Inositol phosphate metabolism_Homo sapiens_hsa005620.58151648
80Melanogenesis_Homo sapiens_hsa049160.56816131
81Endometrial cancer_Homo sapiens_hsa052130.55372436
82Parkinsons disease_Homo sapiens_hsa050120.54543664
83Fructose and mannose metabolism_Homo sapiens_hsa000510.54080648
84Fatty acid degradation_Homo sapiens_hsa000710.54031430
85Arginine and proline metabolism_Homo sapiens_hsa003300.53523663
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.53492506
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.53372978
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52751908
89Hippo signaling pathway_Homo sapiens_hsa043900.52601574
90GnRH signaling pathway_Homo sapiens_hsa049120.52351857
91Vitamin digestion and absorption_Homo sapiens_hsa049770.51824143
92Amoebiasis_Homo sapiens_hsa051460.51380716
93Insulin signaling pathway_Homo sapiens_hsa049100.51295298
94Glucagon signaling pathway_Homo sapiens_hsa049220.50635053
95Viral myocarditis_Homo sapiens_hsa054160.50048572
96Salivary secretion_Homo sapiens_hsa049700.50003890
97MAPK signaling pathway_Homo sapiens_hsa040100.49854475
98Calcium signaling pathway_Homo sapiens_hsa040200.49341994
99cAMP signaling pathway_Homo sapiens_hsa040240.49062060
100Taste transduction_Homo sapiens_hsa047420.48969789
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48430895
102Thyroid cancer_Homo sapiens_hsa052160.48273524
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48015273
104Hedgehog signaling pathway_Homo sapiens_hsa043400.47019192
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46496744
106HIF-1 signaling pathway_Homo sapiens_hsa040660.46177649
107Non-small cell lung cancer_Homo sapiens_hsa052230.46020230
108Glycerolipid metabolism_Homo sapiens_hsa005610.45977560
109Sulfur metabolism_Homo sapiens_hsa009200.45539519
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.44922147
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44918171
112Serotonergic synapse_Homo sapiens_hsa047260.44438858
113Notch signaling pathway_Homo sapiens_hsa043300.44250322
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.44108970
115Toxoplasmosis_Homo sapiens_hsa051450.41487839
116Acute myeloid leukemia_Homo sapiens_hsa052210.41312137
117Fatty acid elongation_Homo sapiens_hsa000620.41078199
118Circadian entrainment_Homo sapiens_hsa047130.40330561
119Synaptic vesicle cycle_Homo sapiens_hsa047210.40286901
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37965497
121Phenylalanine metabolism_Homo sapiens_hsa003600.36704100
122VEGF signaling pathway_Homo sapiens_hsa043700.35646739
123Proteoglycans in cancer_Homo sapiens_hsa052050.35524393
124Focal adhesion_Homo sapiens_hsa045100.35027344
125Axon guidance_Homo sapiens_hsa043600.34519490
126Wnt signaling pathway_Homo sapiens_hsa043100.34281148
127Bladder cancer_Homo sapiens_hsa052190.33325349
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33121561
129Huntingtons disease_Homo sapiens_hsa050160.33002645
130Salmonella infection_Homo sapiens_hsa051320.32198275
131Hepatitis C_Homo sapiens_hsa051600.31723046
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.30511219
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.30193141
134AMPK signaling pathway_Homo sapiens_hsa041520.30134048
135Vibrio cholerae infection_Homo sapiens_hsa051100.29240997

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »