

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ventricular system development (GO:0021591) | 9.89543145 |
| 2 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 9.80593832 |
| 3 | GTP biosynthetic process (GO:0006183) | 9.74460488 |
| 4 | nucleoside diphosphate phosphorylation (GO:0006165) | 9.12035679 |
| 5 | UTP biosynthetic process (GO:0006228) | 8.85450423 |
| 6 | UTP metabolic process (GO:0046051) | 8.11940172 |
| 7 | motile cilium assembly (GO:0044458) | 8.06674221 |
| 8 | left/right axis specification (GO:0070986) | 7.59916046 |
| 9 | CTP biosynthetic process (GO:0006241) | 6.43762381 |
| 10 | CTP metabolic process (GO:0046036) | 6.43762381 |
| 11 | guanosine-containing compound biosynthetic process (GO:1901070) | 6.39804523 |
| 12 | intraciliary transport (GO:0042073) | 6.30207937 |
| 13 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 6.00534874 |
| 14 | microtubule bundle formation (GO:0001578) | 5.78645757 |
| 15 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 5.63209408 |
| 16 | * cilium organization (GO:0044782) | 5.51313806 |
| 17 | cilium assembly (GO:0042384) | 5.37456965 |
| 18 | regulation of cilium movement (GO:0003352) | 5.36786635 |
| 19 | nucleotide phosphorylation (GO:0046939) | 4.96103834 |
| 20 | regulation of macrophage chemotaxis (GO:0010758) | 4.90580138 |
| 21 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 4.80253477 |
| 22 | microtubule-based movement (GO:0007018) | 4.60629770 |
| 23 | cellular component assembly involved in morphogenesis (GO:0010927) | 4.58294160 |
| 24 | cilium morphogenesis (GO:0060271) | 4.39454337 |
| 25 | nucleoside diphosphate metabolic process (GO:0009132) | 4.32915296 |
| 26 | behavioral response to nicotine (GO:0035095) | 4.30206999 |
| 27 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 4.18025918 |
| 28 | sperm motility (GO:0030317) | 4.10148333 |
| 29 | one-carbon compound transport (GO:0019755) | 4.05227038 |
| 30 | response to pheromone (GO:0019236) | 4.05205686 |
| 31 | regulation of mononuclear cell migration (GO:0071675) | 4.04888891 |
| 32 | cell projection assembly (GO:0030031) | 4.03360549 |
| 33 | otic vesicle formation (GO:0030916) | 3.89163552 |
| 34 | indole-containing compound catabolic process (GO:0042436) | 3.86989681 |
| 35 | indolalkylamine catabolic process (GO:0046218) | 3.86989681 |
| 36 | tryptophan catabolic process (GO:0006569) | 3.86989681 |
| 37 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 3.81222801 |
| 38 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 3.80809656 |
| 39 | L-fucose catabolic process (GO:0042355) | 3.78417947 |
| 40 | fucose catabolic process (GO:0019317) | 3.78417947 |
| 41 | L-fucose metabolic process (GO:0042354) | 3.78417947 |
| 42 | DNA deamination (GO:0045006) | 3.78038979 |
| 43 | pyrimidine ribonucleotide biosynthetic process (GO:0009220) | 3.72509395 |
| 44 | ADP metabolic process (GO:0046031) | 3.63137250 |
| 45 | cellular ketone body metabolic process (GO:0046950) | 3.62758761 |
| 46 | spermatid development (GO:0007286) | 3.61811237 |
| 47 | microtubule severing (GO:0051013) | 3.58390065 |
| 48 | kynurenine metabolic process (GO:0070189) | 3.56053807 |
| 49 | indolalkylamine metabolic process (GO:0006586) | 3.54285137 |
| 50 | regulation of inclusion body assembly (GO:0090083) | 3.53280706 |
| 51 | negative regulation of inclusion body assembly (GO:0090084) | 3.48678567 |
| 52 | cornea development in camera-type eye (GO:0061303) | 3.48648181 |
| 53 | tryptophan metabolic process (GO:0006568) | 3.47982614 |
| 54 | ketone body metabolic process (GO:1902224) | 3.31895952 |
| 55 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.30352348 |
| 56 | pyrimidine ribonucleotide metabolic process (GO:0009218) | 3.30163397 |
| 57 | left/right pattern formation (GO:0060972) | 3.29239854 |
| 58 | platelet dense granule organization (GO:0060155) | 3.26678017 |
| 59 | brain morphogenesis (GO:0048854) | 3.24447073 |
| 60 | negative regulation of astrocyte differentiation (GO:0048712) | 3.20206054 |
| 61 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.16981452 |
| 62 | protein localization to cilium (GO:0061512) | 3.15004599 |
| 63 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.14343163 |
| 64 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.12949396 |
| 65 | negative regulation of mast cell activation (GO:0033004) | 3.11599917 |
| 66 | protein complex biogenesis (GO:0070271) | 3.09042911 |
| 67 | regulation of microtubule-based movement (GO:0060632) | 3.08190160 |
| 68 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.06957835 |
| 69 | cellular biogenic amine catabolic process (GO:0042402) | 3.04811228 |
| 70 | amine catabolic process (GO:0009310) | 3.04811228 |
| 71 | piRNA metabolic process (GO:0034587) | 3.04542616 |
| 72 | photoreceptor cell maintenance (GO:0045494) | 3.04012334 |
| 73 | cytochrome complex assembly (GO:0017004) | 3.03877833 |
| 74 | detection of light stimulus involved in visual perception (GO:0050908) | 3.03206652 |
| 75 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.03206652 |
| 76 | mannosylation (GO:0097502) | 3.00115176 |
| 77 | single fertilization (GO:0007338) | 3.00001531 |
| 78 | exogenous drug catabolic process (GO:0042738) | 2.98360936 |
| 79 | determination of left/right symmetry (GO:0007368) | 2.98300244 |
| 80 | neural tube formation (GO:0001841) | 2.98024197 |
| 81 | regulation of pigment cell differentiation (GO:0050932) | 2.97951048 |
| 82 | respiratory chain complex IV assembly (GO:0008535) | 2.97041697 |
| 83 | sperm-egg recognition (GO:0035036) | 2.96993212 |
| 84 | binding of sperm to zona pellucida (GO:0007339) | 2.96809460 |
| 85 | multicellular organismal aging (GO:0010259) | 2.94822840 |
| 86 | lung epithelium development (GO:0060428) | 2.94575024 |
| 87 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.92889453 |
| 88 | organic cation transport (GO:0015695) | 2.91279592 |
| 89 | retinal cone cell development (GO:0046549) | 2.90739316 |
| 90 | acrosome reaction (GO:0007340) | 2.86079207 |
| 91 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.84808387 |
| 92 | nonmotile primary cilium assembly (GO:0035058) | 2.83958432 |
| 93 | determination of bilateral symmetry (GO:0009855) | 2.83619963 |
| 94 | central nervous system myelination (GO:0022010) | 2.83353766 |
| 95 | axon ensheathment in central nervous system (GO:0032291) | 2.83353766 |
| 96 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.82987018 |
| 97 | microglial cell activation (GO:0001774) | 2.82316411 |
| 98 | positive regulation of developmental pigmentation (GO:0048087) | 2.81463239 |
| 99 | ubiquinone biosynthetic process (GO:0006744) | 2.81053175 |
| 100 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.80502382 |
| 101 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.80281655 |
| 102 | NADH dehydrogenase complex assembly (GO:0010257) | 2.80281655 |
| 103 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.80281655 |
| 104 | protein polyglutamylation (GO:0018095) | 2.78209812 |
| 105 | fusion of sperm to egg plasma membrane (GO:0007342) | 2.76671557 |
| 106 | specification of symmetry (GO:0009799) | 2.76549478 |
| 107 | adaptation of signaling pathway (GO:0023058) | 2.73231305 |
| 108 | GPI anchor metabolic process (GO:0006505) | 2.73034123 |
| 109 | glomerular epithelial cell development (GO:0072310) | 2.71888049 |
| 110 | drug catabolic process (GO:0042737) | 2.70406026 |
| 111 | ubiquinone metabolic process (GO:0006743) | 2.69591129 |
| 112 | lateral ventricle development (GO:0021670) | 2.68552086 |
| 113 | response to xenobiotic stimulus (GO:0009410) | 2.68129052 |
| 114 | auditory receptor cell stereocilium organization (GO:0060088) | 2.67476820 |
| 115 | rRNA catabolic process (GO:0016075) | 2.67278832 |
| 116 | DNA methylation involved in gamete generation (GO:0043046) | 2.67118205 |
| 117 | meiotic cell cycle (GO:0051321) | 2.67107585 |
| 118 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.66922821 |
| 119 | pyrimidine nucleotide biosynthetic process (GO:0006221) | 2.66317555 |
| 120 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.64923981 |
| 121 | benzene-containing compound metabolic process (GO:0042537) | 2.64771067 |
| 122 | embryonic digestive tract development (GO:0048566) | 2.64241412 |
| 123 | fertilization (GO:0009566) | 2.62849525 |
| 124 | protein-cofactor linkage (GO:0018065) | 2.62607692 |
| 125 | multicellular organism reproduction (GO:0032504) | 2.61081805 |
| 126 | cell-cell recognition (GO:0009988) | 2.60875552 |
| 127 | male meiosis I (GO:0007141) | 2.60711888 |
| 128 | oxygen transport (GO:0015671) | 2.59949244 |
| 129 | proline transport (GO:0015824) | 2.59226916 |
| 130 | indole-containing compound metabolic process (GO:0042430) | 2.59210222 |
| 131 | negative regulation of telomere maintenance (GO:0032205) | 2.55660786 |
| 132 | NAD biosynthetic process (GO:0009435) | 2.54218453 |
| 133 | regulation of germinal center formation (GO:0002634) | 2.53724547 |
| 134 | smoothened signaling pathway (GO:0007224) | 2.51368904 |
| 135 | embryonic camera-type eye development (GO:0031076) | 2.50025926 |
| 136 | positive regulation of prostaglandin secretion (GO:0032308) | 2.49983962 |
| 137 | oligodendrocyte differentiation (GO:0048709) | 2.49202838 |
| 138 | positive regulation of extracellular matrix organization (GO:1903055) | 2.49052379 |
| 139 | positive regulation of meiosis (GO:0045836) | 2.48148940 |
| 140 | protein refolding (GO:0042026) | 2.48101694 |
| 141 | cell wall macromolecule catabolic process (GO:0016998) | 2.46480049 |
| 142 | cell wall macromolecule metabolic process (GO:0044036) | 2.46480049 |
| 143 | sperm capacitation (GO:0048240) | 2.45722730 |
| 144 | acrosome assembly (GO:0001675) | 2.43513007 |
| 145 | spermatogenesis (GO:0007283) | 2.42945438 |
| 146 | gamma-aminobutyric acid transport (GO:0015812) | 2.42474057 |
| 147 | positive regulation of fatty acid transport (GO:2000193) | 2.42369395 |
| 148 | purine ribonucleoside diphosphate metabolic process (GO:0009179) | 2.41869720 |
| 149 | purine nucleoside diphosphate metabolic process (GO:0009135) | 2.41869720 |
| 150 | male gamete generation (GO:0048232) | 2.41131626 |
| 151 | Sertoli cell development (GO:0060009) | 2.39469400 |
| 152 | centriole replication (GO:0007099) | 2.37119635 |
| 153 | regulation of hexokinase activity (GO:1903299) | 2.36517160 |
| 154 | regulation of glucokinase activity (GO:0033131) | 2.36517160 |
| 155 | regulation of memory T cell differentiation (GO:0043380) | 2.36463066 |
| 156 | inositol phosphate catabolic process (GO:0071545) | 2.33604332 |
| 157 | polyol catabolic process (GO:0046174) | 2.33556731 |
| 158 | centriole assembly (GO:0098534) | 2.33055693 |
| 159 | GPI anchor biosynthetic process (GO:0006506) | 2.32800371 |
| 160 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.31728740 |
| 161 | photoreceptor cell development (GO:0042461) | 2.30501393 |
| 162 | aldehyde catabolic process (GO:0046185) | 2.29921956 |
| 163 | phosphatidylethanolamine metabolic process (GO:0046337) | 2.28805964 |
| 164 | quinone biosynthetic process (GO:1901663) | 2.28394129 |
| 165 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.27900345 |
| 166 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.27900345 |
| 167 | aromatic amino acid family catabolic process (GO:0009074) | 2.27325267 |
| 168 | spinal cord motor neuron differentiation (GO:0021522) | 2.25972888 |
| 169 | cilium movement (GO:0003341) | 16.3555612 |
| 170 | axonemal dynein complex assembly (GO:0070286) | 14.9275265 |
| 171 | cilium or flagellum-dependent cell motility (GO:0001539) | 13.5304045 |
| 172 | axoneme assembly (GO:0035082) | 12.5594041 |
| 173 | epithelial cilium movement (GO:0003351) | 12.3376874 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZNF274_21170338_ChIP-Seq_K562_Hela | 4.01175055 |
| 2 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.70182502 |
| 3 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 3.36069451 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.34283594 |
| 5 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.20856575 |
| 6 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.77737164 |
| 7 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.44191400 |
| 8 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.33107712 |
| 9 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 2.32161276 |
| 10 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.19545771 |
| 11 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 2.09674653 |
| 12 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.00094566 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.99575172 |
| 14 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.88122323 |
| 15 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.86023796 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.85189510 |
| 17 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.82660884 |
| 18 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.82476436 |
| 19 | EWS_26573619_Chip-Seq_HEK293_Human | 1.79686638 |
| 20 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.78930122 |
| 21 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.76560754 |
| 22 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.75243142 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.74224061 |
| 24 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.71581307 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.68284821 |
| 26 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.66533334 |
| 27 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.66473950 |
| 28 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.65232145 |
| 29 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.64504838 |
| 30 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.62192008 |
| 31 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.57028014 |
| 32 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.56568730 |
| 33 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.52751036 |
| 34 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.52220460 |
| 35 | P300_19829295_ChIP-Seq_ESCs_Human | 1.50828313 |
| 36 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.49576320 |
| 37 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.49576320 |
| 38 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.49357428 |
| 39 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.47536050 |
| 40 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.46711092 |
| 41 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.46554841 |
| 42 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.46067272 |
| 43 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.43419018 |
| 44 | AR_20517297_ChIP-Seq_VCAP_Human | 1.43017551 |
| 45 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.42903514 |
| 46 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.41335313 |
| 47 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.40662298 |
| 48 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.40355909 |
| 49 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.40299159 |
| 50 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.40299159 |
| 51 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.40130938 |
| 52 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.40023563 |
| 53 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.38304165 |
| 54 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.38205518 |
| 55 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.38205355 |
| 56 | NCOR_22424771_ChIP-Seq_293T_Human | 1.36910464 |
| 57 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.36581104 |
| 58 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.35577731 |
| 59 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.35245408 |
| 60 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.35230366 |
| 61 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.34393119 |
| 62 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.34393119 |
| 63 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.34333393 |
| 64 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.33417271 |
| 65 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.33153562 |
| 66 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.33055691 |
| 67 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.32039201 |
| 68 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.31857530 |
| 69 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.31716802 |
| 70 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.31668140 |
| 71 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.31666932 |
| 72 | AR_25329375_ChIP-Seq_VCAP_Human | 1.30906207 |
| 73 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.30587552 |
| 74 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.30443328 |
| 75 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.30329998 |
| 76 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.29338692 |
| 77 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.29157634 |
| 78 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28598351 |
| 79 | GATA3_26560356_Chip-Seq_TH2_Human | 1.27565161 |
| 80 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.27188173 |
| 81 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.27180843 |
| 82 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.25311443 |
| 83 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.22519660 |
| 84 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.22464455 |
| 85 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.21341740 |
| 86 | FUS_26573619_Chip-Seq_HEK293_Human | 1.20690068 |
| 87 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.20624158 |
| 88 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.20430173 |
| 89 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.19928416 |
| 90 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.19638123 |
| 91 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.19224041 |
| 92 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.19199623 |
| 93 | STAT3_23295773_ChIP-Seq_U87_Human | 1.18837949 |
| 94 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.18635231 |
| 95 | TBL1_22424771_ChIP-Seq_293T_Human | 1.18100539 |
| 96 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.18019964 |
| 97 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.18018397 |
| 98 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.17856644 |
| 99 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.17758999 |
| 100 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.16899619 |
| 101 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.16845989 |
| 102 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.15059388 |
| 103 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.14785116 |
| 104 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.14193145 |
| 105 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.14058723 |
| 106 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.13576461 |
| 107 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.12784391 |
| 108 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.12666137 |
| 109 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.12558391 |
| 110 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.12239690 |
| 111 | ERA_21632823_ChIP-Seq_H3396_Human | 1.11377561 |
| 112 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.11160721 |
| 113 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.10814686 |
| 114 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.10776218 |
| 115 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.10322742 |
| 116 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.09913911 |
| 117 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.09819141 |
| 118 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.09124598 |
| 119 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.08764125 |
| 120 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.07507691 |
| 121 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.07488360 |
| 122 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.07427826 |
| 123 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.07288123 |
| 124 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.07283988 |
| 125 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.07254891 |
| 126 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07233050 |
| 127 | LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.07221438 |
| 128 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.06887691 |
| 129 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.06758848 |
| 130 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06631255 |
| 131 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.06451522 |
| 132 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06296411 |
| 133 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.06162763 |
| 134 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.05328950 |
| 135 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.04494202 |
| 136 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04210826 |
| 137 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.03798794 |
| 138 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.03612388 |
| 139 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.03439457 |
| 140 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.03344297 |
| 141 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.02577680 |
| 142 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.02456712 |
| 143 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.01979093 |
| 144 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.01882782 |
| 145 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.01750302 |
| 146 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.01564987 |
| 147 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.01305476 |
| 148 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01196352 |
| 149 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00973150 |
| 150 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.00929800 |
| 151 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.00911129 |
| 152 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.00596018 |
| 153 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.00471383 |
| 154 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.98835174 |
| 155 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.98835174 |
| 156 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.97732838 |
| 157 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.97183046 |
| 158 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.97026228 |
| 159 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.97026228 |
| 160 | TCF4_23295773_ChIP-Seq_U87_Human | 0.97006433 |
| 161 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96912037 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 8.85741297 |
| 2 | MP0002653_abnormal_ependyma_morphology | 4.76673115 |
| 3 | MP0005623_abnormal_meninges_morphology | 4.65933543 |
| 4 | MP0008004_abnormal_stomach_pH | 4.48257773 |
| 5 | MP0005410_abnormal_fertilization | 3.76852641 |
| 6 | MP0005646_abnormal_pituitary_gland | 3.55652041 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 3.49299675 |
| 8 | MP0004133_heterotaxia | 2.66083867 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.47991879 |
| 10 | MP0003195_calcinosis | 2.47146082 |
| 11 | MP0002254_reproductive_system_inflammat | 2.38573250 |
| 12 | MP0002102_abnormal_ear_morphology | 2.34206295 |
| 13 | MP0001440_abnormal_grooming_behavior | 2.31741783 |
| 14 | MP0003950_abnormal_plasma_membrane | 2.27008592 |
| 15 | MP0004043_abnormal_pH_regulation | 2.19848399 |
| 16 | MP0009046_muscle_twitch | 2.16731613 |
| 17 | MP0003690_abnormal_glial_cell | 2.11289472 |
| 18 | MP0003011_delayed_dark_adaptation | 2.10867194 |
| 19 | MP0004858_abnormal_nervous_system | 2.02953386 |
| 20 | MP0008872_abnormal_physiological_respon | 2.01726531 |
| 21 | MP0003698_abnormal_male_reproductive | 1.97617915 |
| 22 | MP0003787_abnormal_imprinting | 1.89704664 |
| 23 | MP0002928_abnormal_bile_duct | 1.89497124 |
| 24 | MP0005377_hearing/vestibular/ear_phenot | 1.73455166 |
| 25 | MP0003878_abnormal_ear_physiology | 1.73455166 |
| 26 | MP0000372_irregular_coat_pigmentation | 1.73040826 |
| 27 | MP0002160_abnormal_reproductive_system | 1.71654610 |
| 28 | MP0002837_dystrophic_cardiac_calcinosis | 1.68146084 |
| 29 | MP0003279_aneurysm | 1.63502906 |
| 30 | MP0000049_abnormal_middle_ear | 1.63188849 |
| 31 | MP0002282_abnormal_trachea_morphology | 1.62061363 |
| 32 | MP0009384_cardiac_valve_regurgitation | 1.61020505 |
| 33 | MP0001929_abnormal_gametogenesis | 1.59158504 |
| 34 | MP0008789_abnormal_olfactory_epithelium | 1.55076351 |
| 35 | MP0001501_abnormal_sleep_pattern | 1.53178618 |
| 36 | MP0000569_abnormal_digit_pigmentation | 1.52881999 |
| 37 | MP0005084_abnormal_gallbladder_morpholo | 1.48815307 |
| 38 | MP0003646_muscle_fatigue | 1.46242871 |
| 39 | MP0004859_abnormal_synaptic_plasticity | 1.44690628 |
| 40 | MP0002249_abnormal_larynx_morphology | 1.41849616 |
| 41 | MP0005671_abnormal_response_to | 1.40567769 |
| 42 | MP0004885_abnormal_endolymph | 1.33695592 |
| 43 | MP0004147_increased_porphyrin_level | 1.33234552 |
| 44 | MP0005647_abnormal_sex_gland | 1.32182468 |
| 45 | MP0003634_abnormal_glial_cell | 1.31039602 |
| 46 | MP0002735_abnormal_chemical_nociception | 1.30665801 |
| 47 | MP0002132_abnormal_respiratory_system | 1.27365270 |
| 48 | MP0004381_abnormal_hair_follicle | 1.27212245 |
| 49 | MP0002210_abnormal_sex_determination | 1.25603560 |
| 50 | MP0002572_abnormal_emotion/affect_behav | 1.24866225 |
| 51 | MP0006276_abnormal_autonomic_nervous | 1.22082056 |
| 52 | MP0000427_abnormal_hair_cycle | 1.21852740 |
| 53 | MP0002064_seizures | 1.21130951 |
| 54 | MP0001851_eye_inflammation | 1.20568441 |
| 55 | MP0001984_abnormal_olfaction | 1.20474059 |
| 56 | MP0009745_abnormal_behavioral_response | 1.20303742 |
| 57 | MP0003718_maternal_effect | 1.19012128 |
| 58 | MP0005379_endocrine/exocrine_gland_phen | 1.18210714 |
| 59 | MP0003937_abnormal_limbs/digits/tail_de | 1.18081397 |
| 60 | MP0000383_abnormal_hair_follicle | 1.17992903 |
| 61 | MP0009764_decreased_sensitivity_to | 1.16202877 |
| 62 | MP0002138_abnormal_hepatobiliary_system | 1.15911593 |
| 63 | MP0000428_abnormal_craniofacial_morphol | 1.15612083 |
| 64 | MP0002736_abnormal_nociception_after | 1.14728721 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 1.14551330 |
| 66 | MP0003075_altered_response_to | 1.13892299 |
| 67 | MP0005389_reproductive_system_phenotype | 1.12343770 |
| 68 | MP0005174_abnormal_tail_pigmentation | 1.12333049 |
| 69 | MP0005085_abnormal_gallbladder_physiolo | 1.11882542 |
| 70 | MP0001486_abnormal_startle_reflex | 1.08877325 |
| 71 | MP0003938_abnormal_ear_development | 1.07893530 |
| 72 | MP0009780_abnormal_chondrocyte_physiolo | 1.05275504 |
| 73 | MP0005670_abnormal_white_adipose | 1.04211661 |
| 74 | MP0003635_abnormal_synaptic_transmissio | 1.02131430 |
| 75 | MP0004742_abnormal_vestibular_system | 1.01977763 |
| 76 | MP0001905_abnormal_dopamine_level | 0.99670353 |
| 77 | MP0005394_taste/olfaction_phenotype | 0.99608694 |
| 78 | MP0005499_abnormal_olfactory_system | 0.99608694 |
| 79 | MP0002161_abnormal_fertility/fecundity | 0.99351859 |
| 80 | MP0002733_abnormal_thermal_nociception | 0.99157488 |
| 81 | MP0001968_abnormal_touch/_nociception | 0.99104097 |
| 82 | MP0001765_abnormal_ion_homeostasis | 0.98535297 |
| 83 | MP0001764_abnormal_homeostasis | 0.98342381 |
| 84 | MP0004019_abnormal_vitamin_homeostasis | 0.98135090 |
| 85 | MP0002332_abnormal_exercise_endurance | 0.97917675 |
| 86 | MP0002133_abnormal_respiratory_system | 0.97039359 |
| 87 | MP0005388_respiratory_system_phenotype | 0.97039359 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.95670276 |
| 89 | MP0001986_abnormal_taste_sensitivity | 0.95181738 |
| 90 | MP0005636_abnormal_mineral_homeostasis | 0.94989586 |
| 91 | MP0005551_abnormal_eye_electrophysiolog | 0.94884250 |
| 92 | MP0009250_abnormal_appendicular_skeleto | 0.94514307 |
| 93 | MP0002148_abnormal_hypersensitivity_rea | 0.94120351 |
| 94 | MP0003880_abnormal_central_pattern | 0.93766024 |
| 95 | MP0001485_abnormal_pinna_reflex | 0.93420643 |
| 96 | MP0002909_abnormal_adrenal_gland | 0.93410966 |
| 97 | MP0001177_atelectasis | 0.92194240 |
| 98 | MP0001853_heart_inflammation | 0.92140939 |
| 99 | MP0002557_abnormal_social/conspecific_i | 0.92061132 |
| 100 | MP0006036_abnormal_mitochondrial_physio | 0.91928966 |
| 101 | MP0002938_white_spotting | 0.91828827 |
| 102 | MP0005083_abnormal_biliary_tract | 0.89970651 |
| 103 | MP0010386_abnormal_urinary_bladder | 0.89109316 |
| 104 | MP0005195_abnormal_posterior_eye | 0.87166737 |
| 105 | MP0001879_abnormal_lymphatic_vessel | 0.86559670 |
| 106 | MP0005253_abnormal_eye_physiology | 0.86196985 |
| 107 | MP0002116_abnormal_craniofacial_bone | 0.86008916 |
| 108 | MP0002229_neurodegeneration | 0.85904269 |
| 109 | MP0003806_abnormal_nucleotide_metabolis | 0.85835902 |
| 110 | MP0005165_increased_susceptibility_to | 0.85458139 |
| 111 | MP0009115_abnormal_fat_cell | 0.85257269 |
| 112 | MP0001270_distended_abdomen | 0.83730974 |
| 113 | MP0002876_abnormal_thyroid_physiology | 0.83581604 |
| 114 | MP0001145_abnormal_male_reproductive | 0.83499039 |
| 115 | MP0002295_abnormal_pulmonary_circulatio | 0.83202579 |
| 116 | MP0002272_abnormal_nervous_system | 0.82826754 |
| 117 | MP0004924_abnormal_behavior | 0.82688414 |
| 118 | MP0005386_behavior/neurological_phenoty | 0.82688414 |
| 119 | MP0001919_abnormal_reproductive_system | 0.82273296 |
| 120 | MP0005332_abnormal_amino_acid | 0.82009266 |
| 121 | MP0000230_abnormal_systemic_arterial | 0.81757207 |
| 122 | MP0001502_abnormal_circadian_rhythm | 0.81462650 |
| 123 | MP0000653_abnormal_sex_gland | 0.81110959 |
| 124 | MP0005365_abnormal_bile_salt | 0.80920247 |
| 125 | MP0001529_abnormal_vocalization | 0.80833002 |
| 126 | MP0002067_abnormal_sensory_capabilities | 0.79935992 |
| 127 | MP0003633_abnormal_nervous_system | 0.78394321 |
| 128 | MP0003724_increased_susceptibility_to | 0.78374212 |
| 129 | MP0008058_abnormal_DNA_repair | 0.77850534 |
| 130 | MP0000778_abnormal_nervous_system | 0.77847522 |
| 131 | MP0002109_abnormal_limb_morphology | 0.77147188 |
| 132 | MP0002152_abnormal_brain_morphology | 0.77039334 |
| 133 | MP0002277_abnormal_respiratory_mucosa | 0.76682867 |
| 134 | MP0003252_abnormal_bile_duct | 0.76067424 |
| 135 | MP0009785_altered_susceptibility_to | 0.76033538 |
| 136 | MP0002063_abnormal_learning/memory/cond | 0.75490198 |
| 137 | MP0005391_vision/eye_phenotype | 0.75240386 |
| 138 | MP0004142_abnormal_muscle_tone | 0.72022608 |
| 139 | MP0005167_abnormal_blood-brain_barrier | 0.69436990 |
| 140 | MP0006072_abnormal_retinal_apoptosis | 0.68135013 |
| 141 | MP0003942_abnormal_urinary_system | 0.67840324 |
| 142 | MP0002638_abnormal_pupillary_reflex | 0.67461502 |
| 143 | MP0000470_abnormal_stomach_morphology | 0.66358659 |
| 144 | MP0003755_abnormal_palate_morphology | 0.66002805 |
| 145 | MP0002734_abnormal_mechanical_nocicepti | 0.63829457 |
| 146 | MP0003861_abnormal_nervous_system | 0.63300432 |
| 147 | MP0004883_abnormal_blood_vessel | 0.63263448 |
| 148 | MP0006292_abnormal_olfactory_placode | 0.63070008 |
| 149 | MP0008995_early_reproductive_senescence | 0.62703760 |
| 150 | MP0000432_abnormal_head_morphology | 0.62010866 |
| 151 | MP0008569_lethality_at_weaning | 0.61382031 |
| 152 | MP0005645_abnormal_hypothalamus_physiol | 0.61273703 |
| 153 | MP0002127_abnormal_cardiovascular_syste | 0.60081610 |
| 154 | MP0001970_abnormal_pain_threshold | 0.58756583 |
| 155 | MP0004484_altered_response_of | 0.56581351 |
| 156 | MP0003943_abnormal_hepatobiliary_system | 0.56314968 |
| 157 | MP0002092_abnormal_eye_morphology | 0.55920206 |
| 158 | MP0000026_abnormal_inner_ear | 0.55866618 |
| 159 | MP0001340_abnormal_eyelid_morphology | 0.54805057 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal respiratory motile cilium morphology (HP:0005938) | 9.44660624 |
| 2 | Abnormal respiratory epithelium morphology (HP:0012253) | 9.44660624 |
| 3 | Absent/shortened dynein arms (HP:0200106) | 8.02258598 |
| 4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 8.02258598 |
| 5 | Chronic bronchitis (HP:0004469) | 6.76909178 |
| 6 | Bronchiectasis (HP:0002110) | 5.59251414 |
| 7 | Nasal polyposis (HP:0100582) | 4.72665715 |
| 8 | Pancreatic fibrosis (HP:0100732) | 4.36523615 |
| 9 | True hermaphroditism (HP:0010459) | 4.17414021 |
| 10 | Abnormality of the nasal mucosa (HP:0000433) | 3.89077272 |
| 11 | Chronic sinusitis (HP:0011109) | 3.49510905 |
| 12 | Recurrent sinusitis (HP:0011108) | 3.47517608 |
| 13 | Congenital stationary night blindness (HP:0007642) | 3.36966051 |
| 14 | Bronchitis (HP:0012387) | 3.33409810 |
| 15 | Supernumerary spleens (HP:0009799) | 3.32619888 |
| 16 | Nephronophthisis (HP:0000090) | 3.29272742 |
| 17 | Bile duct proliferation (HP:0001408) | 3.22883199 |
| 18 | Abnormal biliary tract physiology (HP:0012439) | 3.22883199 |
| 19 | Abnormality of the renal cortex (HP:0011035) | 3.17308180 |
| 20 | Infertility (HP:0000789) | 3.16436778 |
| 21 | Occipital encephalocele (HP:0002085) | 3.13297455 |
| 22 | Median cleft lip (HP:0000161) | 3.09459779 |
| 23 | Abnormality of dentin (HP:0010299) | 3.06754309 |
| 24 | Pancreatic cysts (HP:0001737) | 2.87186417 |
| 25 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.86836257 |
| 26 | Cystic liver disease (HP:0006706) | 2.76118240 |
| 27 | Tubulointerstitial nephritis (HP:0001970) | 2.69949138 |
| 28 | Congenital hepatic fibrosis (HP:0002612) | 2.68208610 |
| 29 | Attenuation of retinal blood vessels (HP:0007843) | 2.60264041 |
| 30 | Medial flaring of the eyebrow (HP:0010747) | 2.59838964 |
| 31 | Molar tooth sign on MRI (HP:0002419) | 2.58976996 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 2.58976996 |
| 33 | Abolished electroretinogram (ERG) (HP:0000550) | 2.56975286 |
| 34 | Abnormality of permanent molar morphology (HP:0011071) | 2.56678468 |
| 35 | Abnormality of the dental root (HP:0006486) | 2.56678468 |
| 36 | Taurodontia (HP:0000679) | 2.56678468 |
| 37 | Type II lissencephaly (HP:0007260) | 2.55552391 |
| 38 | Postaxial foot polydactyly (HP:0001830) | 2.55494210 |
| 39 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.52756280 |
| 40 | Recurrent otitis media (HP:0000403) | 2.51971502 |
| 41 | Decreased central vision (HP:0007663) | 2.50385214 |
| 42 | Male infertility (HP:0003251) | 2.48894005 |
| 43 | Abnormality of the renal medulla (HP:0100957) | 2.41931578 |
| 44 | Abnormality of the dental pulp (HP:0006479) | 2.41512342 |
| 45 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.38969808 |
| 46 | Abnormality of molar (HP:0011077) | 2.37825253 |
| 47 | Abnormality of molar morphology (HP:0011070) | 2.37825253 |
| 48 | Gait imbalance (HP:0002141) | 2.33437582 |
| 49 | Back pain (HP:0003418) | 2.32569882 |
| 50 | Tubular atrophy (HP:0000092) | 2.32516750 |
| 51 | Congenital primary aphakia (HP:0007707) | 2.32362065 |
| 52 | Renal cortical cysts (HP:0000803) | 2.27072120 |
| 53 | Fibular hypoplasia (HP:0003038) | 2.24457662 |
| 54 | Hyperventilation (HP:0002883) | 2.23701562 |
| 55 | Chronic hepatic failure (HP:0100626) | 2.23130273 |
| 56 | Esophageal neoplasm (HP:0100751) | 2.20547361 |
| 57 | Neoplasm of head and neck (HP:0012288) | 2.20547361 |
| 58 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.17173168 |
| 59 | Polyuria (HP:0000103) | 2.13143028 |
| 60 | Stomatitis (HP:0010280) | 2.11499717 |
| 61 | Preaxial hand polydactyly (HP:0001177) | 2.08185892 |
| 62 | Male pseudohermaphroditism (HP:0000037) | 2.01449126 |
| 63 | Mitochondrial inheritance (HP:0001427) | 2.00696805 |
| 64 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 12.7945186 |
| 65 | Abnormal respiratory motile cilium physiology (HP:0012261) | 12.4310755 |
| 66 | Abnormal ciliary motility (HP:0012262) | 12.1533521 |
| 67 | Rhinitis (HP:0012384) | 10.1251057 |
| 68 | Progressive inability to walk (HP:0002505) | 1.98098804 |
| 69 | Inability to walk (HP:0002540) | 1.98008582 |
| 70 | Abdominal situs inversus (HP:0003363) | 1.97758924 |
| 71 | Abnormality of abdominal situs (HP:0011620) | 1.97758924 |
| 72 | Decreased circulating renin level (HP:0003351) | 1.97492836 |
| 73 | Pendular nystagmus (HP:0012043) | 1.95534306 |
| 74 | Increased CSF lactate (HP:0002490) | 1.95304512 |
| 75 | Facial cleft (HP:0002006) | 1.93517761 |
| 76 | Anencephaly (HP:0002323) | 1.93419997 |
| 77 | Stage 5 chronic kidney disease (HP:0003774) | 1.92953481 |
| 78 | Nephrogenic diabetes insipidus (HP:0009806) | 1.92842277 |
| 79 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.92528216 |
| 80 | Increased corneal curvature (HP:0100692) | 1.90292825 |
| 81 | Keratoconus (HP:0000563) | 1.90292825 |
| 82 | Stomach cancer (HP:0012126) | 1.89986084 |
| 83 | 3-Methylglutaconic aciduria (HP:0003535) | 1.88171959 |
| 84 | Asplenia (HP:0001746) | 1.87693560 |
| 85 | Severe visual impairment (HP:0001141) | 1.85372701 |
| 86 | Postaxial hand polydactyly (HP:0001162) | 1.85104314 |
| 87 | Acute necrotizing encephalopathy (HP:0006965) | 1.84547734 |
| 88 | Abnormality of macular pigmentation (HP:0008002) | 1.83990677 |
| 89 | Absent speech (HP:0001344) | 1.83764090 |
| 90 | Abnormal sex determination (HP:0012244) | 1.83052070 |
| 91 | Sex reversal (HP:0012245) | 1.83052070 |
| 92 | Genital tract atresia (HP:0001827) | 1.82578228 |
| 93 | Large for gestational age (HP:0001520) | 1.82474956 |
| 94 | Hypothermia (HP:0002045) | 1.81143021 |
| 95 | Hepatocellular necrosis (HP:0001404) | 1.79886837 |
| 96 | Congenital, generalized hypertrichosis (HP:0004540) | 1.78051050 |
| 97 | Neonatal short-limb short stature (HP:0008921) | 1.77914171 |
| 98 | Gaze-evoked nystagmus (HP:0000640) | 1.77227708 |
| 99 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.75588190 |
| 100 | Hypotelorism (HP:0000601) | 1.74492335 |
| 101 | Agitation (HP:0000713) | 1.73889290 |
| 102 | Abnormal urine output (HP:0012590) | 1.71835203 |
| 103 | Oculomotor apraxia (HP:0000657) | 1.71027325 |
| 104 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.70126445 |
| 105 | Single umbilical artery (HP:0001195) | 1.70126445 |
| 106 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.70126445 |
| 107 | Lissencephaly (HP:0001339) | 1.69309980 |
| 108 | Retinitis pigmentosa (HP:0000510) | 1.68862085 |
| 109 | Cerebellar dysplasia (HP:0007033) | 1.68229099 |
| 110 | Poor coordination (HP:0002370) | 1.67690965 |
| 111 | Chronic otitis media (HP:0000389) | 1.67347116 |
| 112 | Progressive macrocephaly (HP:0004481) | 1.66992449 |
| 113 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.66212885 |
| 114 | Hepatic necrosis (HP:0002605) | 1.65717660 |
| 115 | Tubulointerstitial fibrosis (HP:0005576) | 1.65515366 |
| 116 | Retinal dysplasia (HP:0007973) | 1.64402464 |
| 117 | Acute encephalopathy (HP:0006846) | 1.63806892 |
| 118 | Concave nail (HP:0001598) | 1.62646370 |
| 119 | Abnormality of renal excretion (HP:0011036) | 1.61987574 |
| 120 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.61587385 |
| 121 | Tubulointerstitial abnormality (HP:0001969) | 1.60922107 |
| 122 | Broad distal phalanx of finger (HP:0009836) | 1.60469443 |
| 123 | Broad-based gait (HP:0002136) | 1.60242072 |
| 124 | Hemiparesis (HP:0001269) | 1.60162898 |
| 125 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.59446504 |
| 126 | Aplasia of the phalanges of the hand (HP:0009802) | 1.57368317 |
| 127 | Aplasia involving bones of the extremities (HP:0009825) | 1.57368317 |
| 128 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.57368317 |
| 129 | Vaginal atresia (HP:0000148) | 1.57177407 |
| 130 | Sclerocornea (HP:0000647) | 1.56200366 |
| 131 | Ectopic anus (HP:0004397) | 1.46839837 |
| 132 | Furrowed tongue (HP:0000221) | 1.46712185 |
| 133 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 1.45450722 |
| 134 | Atelectasis (HP:0100750) | 1.38970344 |
| 135 | Short nail (HP:0001799) | 1.38666596 |
| 136 | Nephropathy (HP:0000112) | 1.37668651 |
| 137 | Abnormal drinking behavior (HP:0030082) | 1.37076353 |
| 138 | Polydipsia (HP:0001959) | 1.37076353 |
| 139 | Transposition of the great arteries (HP:0001669) | 1.32327887 |
| 140 | Abnormal connection of the cardiac segments (HP:0011545) | 1.32327887 |
| 141 | Abnormal ventriculo-arterial connection (HP:0011563) | 1.32327887 |
| 142 | Megalencephaly (HP:0001355) | 1.30208428 |
| 143 | Hypodontia (HP:0000668) | 1.30130863 |
| 144 | Polycystic kidney dysplasia (HP:0000113) | 1.28124551 |
| 145 | Aplasia/Hypoplasia of the scapulae (HP:0006713) | 1.27174445 |
| 146 | Hypoplastic scapulae (HP:0000882) | 1.27174445 |
| 147 | Short thorax (HP:0010306) | 1.26237779 |
| 148 | Epileptic encephalopathy (HP:0200134) | 1.24280439 |
| 149 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.23004326 |
| 150 | Omphalocele (HP:0001539) | 1.21944052 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAPK15 | 8.80894261 |
| 2 | PNCK | 6.74301804 |
| 3 | FRK | 5.18324213 |
| 4 | BMPR1B | 3.17767132 |
| 5 | MAP4K2 | 3.00313909 |
| 6 | MST4 | 2.72938274 |
| 7 | TAOK3 | 2.60281702 |
| 8 | NUAK1 | 2.60001853 |
| 9 | TLK1 | 2.59474985 |
| 10 | PDK4 | 2.54447719 |
| 11 | PDK3 | 2.54447719 |
| 12 | PDK2 | 2.54179995 |
| 13 | ZAK | 2.47844014 |
| 14 | WNK3 | 2.24588988 |
| 15 | WNK4 | 2.16504223 |
| 16 | INSRR | 2.02640827 |
| 17 | WEE1 | 1.97209338 |
| 18 | GRK1 | 1.94434436 |
| 19 | TXK | 1.84799827 |
| 20 | LMTK2 | 1.79281812 |
| 21 | NTRK2 | 1.71216562 |
| 22 | VRK1 | 1.69795998 |
| 23 | MAPK13 | 1.68348894 |
| 24 | TRIM28 | 1.66748531 |
| 25 | OXSR1 | 1.55516069 |
| 26 | BCKDK | 1.50492002 |
| 27 | CASK | 1.48101147 |
| 28 | STK39 | 1.44769792 |
| 29 | TGFBR2 | 1.41766586 |
| 30 | GRK7 | 1.32456284 |
| 31 | GRK5 | 1.23049306 |
| 32 | MAPKAPK3 | 1.19637092 |
| 33 | MAP2K7 | 1.19383823 |
| 34 | MAP3K4 | 1.15025054 |
| 35 | TEC | 1.13510620 |
| 36 | PTK2B | 1.12724996 |
| 37 | KIT | 1.10011686 |
| 38 | CDC42BPA | 1.09104681 |
| 39 | PAK2 | 1.05205807 |
| 40 | STK10 | 1.03010186 |
| 41 | MAP3K6 | 1.01826572 |
| 42 | ADRBK2 | 1.01700596 |
| 43 | ITK | 1.01157651 |
| 44 | BCR | 1.00228294 |
| 45 | EPHA4 | 0.97619904 |
| 46 | NME1 | 0.97195242 |
| 47 | IKBKB | 0.96092838 |
| 48 | CDK12 | 0.96055795 |
| 49 | TGFBR1 | 0.95412953 |
| 50 | BRSK2 | 0.95162080 |
| 51 | CDK8 | 0.94974136 |
| 52 | CDK3 | 0.94775747 |
| 53 | CSNK1G3 | 0.94406456 |
| 54 | RPS6KA2 | 0.92268363 |
| 55 | RIPK4 | 0.89412350 |
| 56 | NTRK3 | 0.89330936 |
| 57 | VRK2 | 0.88248806 |
| 58 | BMPR2 | 0.88056257 |
| 59 | PLK2 | 0.87009954 |
| 60 | CSNK1G2 | 0.86592986 |
| 61 | MAP2K2 | 0.84351579 |
| 62 | PAK3 | 0.83390127 |
| 63 | PRKCG | 0.81661168 |
| 64 | CSNK1G1 | 0.79922378 |
| 65 | ERBB3 | 0.77303745 |
| 66 | PRKCQ | 0.76276060 |
| 67 | STK3 | 0.74488829 |
| 68 | PAK6 | 0.74425102 |
| 69 | MUSK | 0.74054072 |
| 70 | MAPK7 | 0.73298002 |
| 71 | CSNK1A1L | 0.72563873 |
| 72 | DYRK2 | 0.70260241 |
| 73 | DAPK2 | 0.69813129 |
| 74 | RAF1 | 0.68716984 |
| 75 | PHKG2 | 0.68463082 |
| 76 | PHKG1 | 0.68463082 |
| 77 | MAP2K6 | 0.68106172 |
| 78 | FGR | 0.66540661 |
| 79 | GSK3A | 0.65982895 |
| 80 | RPS6KL1 | 0.65361119 |
| 81 | RPS6KC1 | 0.65361119 |
| 82 | SIK1 | 0.64836329 |
| 83 | IRAK4 | 0.64193449 |
| 84 | IRAK1 | 0.62009976 |
| 85 | YES1 | 0.61409013 |
| 86 | SYK | 0.60724155 |
| 87 | TIE1 | 0.60477884 |
| 88 | TNK2 | 0.60182365 |
| 89 | CAMKK1 | 0.59852321 |
| 90 | DYRK3 | 0.58598786 |
| 91 | GRK6 | 0.57101814 |
| 92 | ROCK2 | 0.56563600 |
| 93 | MAPKAPK5 | 0.55766012 |
| 94 | ADRBK1 | 0.55580248 |
| 95 | ICK | 0.54576383 |
| 96 | EPHA3 | 0.53193251 |
| 97 | PBK | 0.52220642 |
| 98 | PLK4 | 0.52162603 |
| 99 | MOS | 0.50922766 |
| 100 | RPS6KA6 | 0.50607331 |
| 101 | PRKCI | 0.50203100 |
| 102 | STK11 | 0.49738746 |
| 103 | ROCK1 | 0.49679554 |
| 104 | DMPK | 0.49249950 |
| 105 | CAMK2A | 0.47200845 |
| 106 | MATK | 0.46487179 |
| 107 | PIK3CA | 0.46354107 |
| 108 | PINK1 | 0.45777606 |
| 109 | LYN | 0.44819183 |
| 110 | CSNK1A1 | 0.44735614 |
| 111 | CAMKK2 | 0.44071228 |
| 112 | IGF1R | 0.43502216 |
| 113 | DDR2 | 0.43262713 |
| 114 | FER | 0.43000178 |
| 115 | CHUK | 0.42917182 |
| 116 | HCK | 0.42473299 |
| 117 | MST1R | 0.42414323 |
| 118 | PRKG1 | 0.41404089 |
| 119 | IKBKE | 0.41354154 |
| 120 | PRKCA | 0.40358067 |
| 121 | AURKA | 0.39921413 |
| 122 | FGFR2 | 0.39545386 |
| 123 | PRKCZ | 0.39084260 |
| 124 | STK16 | 0.37997850 |
| 125 | FLT3 | 0.37651569 |
| 126 | EIF2AK3 | 0.37476395 |
| 127 | BRD4 | 0.37462237 |
| 128 | MARK3 | 0.37327055 |
| 129 | PKN1 | 0.36940741 |
| 130 | MAPK12 | 0.36758250 |
| 131 | STK38L | 0.36221398 |
| 132 | NEK6 | 0.36152345 |
| 133 | ABL1 | 0.36104195 |
| 134 | PRKACA | 0.35859519 |
| 135 | MARK1 | 0.35278006 |
| 136 | CSNK1D | 0.34718891 |
| 137 | RPS6KA4 | 0.34086484 |
| 138 | MAPKAPK2 | 0.33280391 |
| 139 | MAP4K1 | 0.33166328 |
| 140 | CAMK1 | 0.32880988 |
| 141 | PRKD2 | 0.31490770 |
| 142 | OBSCN | 0.31124473 |
| 143 | EGFR | 0.30617574 |
| 144 | PRKDC | 0.30141983 |
| 145 | PRKACG | 0.29603057 |
| 146 | MKNK2 | 0.29577284 |
| 147 | ARAF | 0.29526486 |
| 148 | SRC | 0.28880572 |
| 149 | PIM2 | 0.28191355 |
| 150 | ACVR1B | 0.27958711 |
| 151 | PRKCE | 0.27738519 |
| 152 | PLK3 | 0.27712539 |
| 153 | RPS6KA5 | 0.27587996 |
| 154 | FES | 0.27527108 |
| 155 | PRKACB | 0.26576478 |
| 156 | LATS2 | 0.26275365 |
| 157 | WNK1 | 0.26080758 |
| 158 | RPS6KA3 | 0.26050971 |
| 159 | KSR2 | 0.25482734 |
| 160 | MAPK10 | 0.25116121 |
| 161 | TTK | 0.24683662 |
| 162 | TRPM7 | 0.24588167 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Huntingtons disease_Homo sapiens_hsa05016 | 3.45421302 |
| 2 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 3.39908114 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.88172074 |
| 4 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.66038557 |
| 5 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.48604472 |
| 6 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.39460852 |
| 7 | Nicotine addiction_Homo sapiens_hsa05033 | 2.18816409 |
| 8 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.06021827 |
| 9 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.05323584 |
| 10 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.01775747 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.98790388 |
| 12 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.98521341 |
| 13 | Asthma_Homo sapiens_hsa05310 | 1.97006066 |
| 14 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.88870234 |
| 15 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.83275243 |
| 16 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.82575229 |
| 17 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.76398333 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.73595581 |
| 19 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.69768156 |
| 20 | Mineral absorption_Homo sapiens_hsa04978 | 1.67467936 |
| 21 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.66637209 |
| 22 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.66561154 |
| 23 | Salivary secretion_Homo sapiens_hsa04970 | 1.58706960 |
| 24 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.57824815 |
| 25 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.54524622 |
| 26 | Olfactory transduction_Homo sapiens_hsa04740 | 1.52500410 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.52285274 |
| 28 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.52102189 |
| 29 | Peroxisome_Homo sapiens_hsa04146 | 1.51766748 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.50012322 |
| 31 | RNA polymerase_Homo sapiens_hsa03020 | 1.49609328 |
| 32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.46835506 |
| 33 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.45663106 |
| 34 | Protein export_Homo sapiens_hsa03060 | 1.45188764 |
| 35 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.42053895 |
| 36 | Renin secretion_Homo sapiens_hsa04924 | 1.39873167 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.39847689 |
| 38 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.37786908 |
| 39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.36749355 |
| 40 | Cocaine addiction_Homo sapiens_hsa05030 | 1.35019980 |
| 41 | Circadian entrainment_Homo sapiens_hsa04713 | 1.33503084 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.32347779 |
| 43 | Circadian rhythm_Homo sapiens_hsa04710 | 1.27023106 |
| 44 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.26894897 |
| 45 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.25069046 |
| 46 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.25046762 |
| 47 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.23250984 |
| 48 | GABAergic synapse_Homo sapiens_hsa04727 | 1.22299374 |
| 49 | Insulin secretion_Homo sapiens_hsa04911 | 1.21170992 |
| 50 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.19122057 |
| 51 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.16934430 |
| 52 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.14532419 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.14505251 |
| 54 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.13845596 |
| 55 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.13533910 |
| 56 | Basal transcription factors_Homo sapiens_hsa03022 | 1.12096009 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11954564 |
| 58 | Alzheimers disease_Homo sapiens_hsa05010 | 1.09846712 |
| 59 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.09709476 |
| 60 | Long-term potentiation_Homo sapiens_hsa04720 | 1.09385074 |
| 61 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.07935931 |
| 62 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.07481519 |
| 63 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.05900433 |
| 64 | Phototransduction_Homo sapiens_hsa04744 | 1.05832179 |
| 65 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.04582741 |
| 66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.03253105 |
| 67 | ABC transporters_Homo sapiens_hsa02010 | 1.02998288 |
| 68 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.01429400 |
| 69 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.00095172 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.95802905 |
| 71 | Prion diseases_Homo sapiens_hsa05020 | 0.95480731 |
| 72 | Taste transduction_Homo sapiens_hsa04742 | 0.95326596 |
| 73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.94478640 |
| 74 | Purine metabolism_Homo sapiens_hsa00230 | 0.93846354 |
| 75 | Proteasome_Homo sapiens_hsa03050 | 0.92576480 |
| 76 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.92331432 |
| 77 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.92295644 |
| 78 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.91605280 |
| 79 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.89171363 |
| 80 | RNA degradation_Homo sapiens_hsa03018 | 0.87796762 |
| 81 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87546976 |
| 82 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.87143075 |
| 83 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.85312089 |
| 84 | Melanogenesis_Homo sapiens_hsa04916 | 0.84991564 |
| 85 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.84949019 |
| 86 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.84838013 |
| 87 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.83075732 |
| 88 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.82725236 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82703706 |
| 90 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.81661683 |
| 91 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.80384396 |
| 92 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.79812945 |
| 93 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.78065950 |
| 94 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.76060573 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.75856544 |
| 96 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.75142186 |
| 97 | Long-term depression_Homo sapiens_hsa04730 | 0.73183875 |
| 98 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.71112427 |
| 99 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.70271674 |
| 100 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.70013184 |
| 101 | Morphine addiction_Homo sapiens_hsa05032 | 0.69897389 |
| 102 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.69889702 |
| 103 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.67701482 |
| 104 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.67461365 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.66456050 |
| 106 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66164092 |
| 107 | Gap junction_Homo sapiens_hsa04540 | 0.64947292 |
| 108 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64278110 |
| 109 | Parkinsons disease_Homo sapiens_hsa05012 | 0.63395767 |
| 110 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.62623542 |
| 111 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.62525138 |
| 112 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.62343453 |
| 113 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.60834868 |
| 114 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60517564 |
| 115 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.56162019 |
| 116 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.55789644 |
| 117 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.55302631 |
| 118 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.54806044 |
| 119 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.53532393 |
| 120 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52099847 |
| 121 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.50769901 |
| 122 | Retinol metabolism_Homo sapiens_hsa00830 | 0.50605200 |
| 123 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.50540242 |
| 124 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.49891277 |
| 125 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.49068428 |
| 126 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48511244 |
| 127 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.48451331 |
| 128 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.47387785 |
| 129 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.47205923 |
| 130 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46993210 |
| 131 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.46002924 |
| 132 | Homologous recombination_Homo sapiens_hsa03440 | 0.45613308 |
| 133 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.45156868 |
| 134 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.44759068 |
| 135 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.44032036 |
| 136 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.43116029 |
| 137 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.42996499 |
| 138 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.42962481 |
| 139 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.42895352 |
| 140 | Phagosome_Homo sapiens_hsa04145 | 0.41767904 |
| 141 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.41649608 |
| 142 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.41391750 |
| 143 | Lysosome_Homo sapiens_hsa04142 | 0.41231476 |
| 144 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.40893530 |
| 145 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.39848656 |
| 146 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.36290715 |
| 147 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.36004947 |
| 148 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34830115 |
| 149 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.34543859 |

