CATSPER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.75503533
2* reproduction (GO:0000003)9.00719486
3* plasma membrane fusion (GO:0045026)8.66936887
4cilium movement (GO:0003341)8.57626363
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.07414052
6sperm capacitation (GO:0048240)7.81068845
7piRNA metabolic process (GO:0034587)7.72287523
8male meiosis (GO:0007140)7.68582035
9synaptonemal complex organization (GO:0070193)7.49234168
10* single fertilization (GO:0007338)7.45102080
11synaptonemal complex assembly (GO:0007130)7.24499535
12negative regulation of inclusion body assembly (GO:0090084)7.10318279
13neutrophil activation involved in immune response (GO:0002283)6.90694433
14* spermatogenesis (GO:0007283)6.65353989
15* male gamete generation (GO:0048232)6.62904701
16microtubule depolymerization (GO:0007019)6.58841785
17* regulation of cilium movement (GO:0003352)6.50574649
18organic cation transport (GO:0015695)6.46793437
19* fertilization (GO:0009566)6.37332146
20* gamete generation (GO:0007276)6.08837445
21regulation of inclusion body assembly (GO:0090083)5.86584432
22ventricular system development (GO:0021591)5.67201594
23calcium ion-dependent exocytosis (GO:0017156)5.65006061
24germ cell development (GO:0007281)5.56978968
25* cellular process involved in reproduction in multicellular organism (GO:0022412)5.43419958
26male meiosis I (GO:0007141)5.27048719
27microtubule severing (GO:0051013)5.14039685
28chromosome organization involved in meiosis (GO:0070192)4.97767283
29* cell recognition (GO:0008037)4.91509056
30DNA methylation involved in gamete generation (GO:0043046)4.89322458
31glycerol ether metabolic process (GO:0006662)4.84424316
32* multicellular organismal reproductive process (GO:0048609)4.80724411
33spermatid nucleus differentiation (GO:0007289)4.71569503
34chromosome condensation (GO:0030261)4.68154671
35left/right pattern formation (GO:0060972)4.67895896
36response to peptidoglycan (GO:0032494)4.58992939
37positive regulation of mast cell activation (GO:0033005)4.58928127
38seminiferous tubule development (GO:0072520)4.57844614
39meiotic nuclear division (GO:0007126)4.47773828
40ether metabolic process (GO:0018904)4.47662835
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46769714
42DNA packaging (GO:0006323)4.42369531
43regulation of mast cell degranulation (GO:0043304)4.36569751
44neutrophil activation (GO:0042119)4.33262984
45granulocyte activation (GO:0036230)4.21302486
46meiosis I (GO:0007127)4.19810905
47positive regulation of mast cell activation involved in immune response (GO:0033008)4.09846525
48positive regulation of mast cell degranulation (GO:0043306)4.09846525
49protein polyglutamylation (GO:0018095)4.06776789
50regulation of mast cell activation involved in immune response (GO:0033006)4.05498669
51chaperone-mediated protein complex assembly (GO:0051131)3.97314972
52adenosine receptor signaling pathway (GO:0001973)3.91403533
53leukocyte degranulation (GO:0043299)3.89382675
54myeloid cell activation involved in immune response (GO:0002275)3.89030399
55* multicellular organismal development (GO:0007275)3.85517902
56genitalia morphogenesis (GO:0035112)3.82807627
57monoubiquitinated protein deubiquitination (GO:0035520)3.72013462
58negative regulation of interleukin-12 production (GO:0032695)3.71616978
59regulation of mast cell activation (GO:0033003)3.71608908
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67737261
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67737261
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.67737261
63modulation by symbiont of host immune response (GO:0052553)3.67737261
64positive regulation by symbiont of host defense response (GO:0052509)3.67737261
65modulation by symbiont of host defense response (GO:0052031)3.67737261
66macrophage activation involved in immune response (GO:0002281)3.65864724
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.65080830
68regulation of leukocyte degranulation (GO:0043300)3.63485217
69single strand break repair (GO:0000012)3.63249148
70* regulation of microtubule-based movement (GO:0060632)3.58400812
71leukocyte migration involved in inflammatory response (GO:0002523)3.56981644
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56117435
73negative regulation of cell killing (GO:0031342)3.56117435
74protein localization to cilium (GO:0061512)3.52303761
75lipoxygenase pathway (GO:0019372)3.52197026
76meiotic cell cycle (GO:0051321)3.51993681
77sexual reproduction (GO:0019953)3.48794996
78positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.48422742
79positive regulation of leukocyte degranulation (GO:0043302)3.45098548
80regulation of spindle checkpoint (GO:0090231)3.41801105
81protein refolding (GO:0042026)3.36237906
82microtubule polymerization or depolymerization (GO:0031109)3.33833482
83immunoglobulin mediated immune response (GO:0016064)3.33745351
84negative regulation of interleukin-17 production (GO:0032700)3.30196053
85regulation of T-helper 2 cell differentiation (GO:0045628)3.28953883
86amino-acid betaine transport (GO:0015838)3.27333194
87carnitine transport (GO:0015879)3.27333194
88regulation of platelet activation (GO:0010543)3.26830977
89regulation of platelet aggregation (GO:0090330)3.26271709
90barbed-end actin filament capping (GO:0051016)3.24410147
91cellular response to thyroid hormone stimulus (GO:0097067)3.22685228
92glycolytic process (GO:0006096)3.21089442
93detection of other organism (GO:0098543)3.19014589
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18360093
95protein K11-linked deubiquitination (GO:0035871)3.16891420
96negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16709170
97regulation of interleukin-17 production (GO:0032660)3.15550082
98mitotic sister chromatid cohesion (GO:0007064)3.15124369
99carnitine transmembrane transport (GO:1902603)3.12702066
100nucleoside diphosphate phosphorylation (GO:0006165)3.11833853
101G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.07530868
102cilium organization (GO:0044782)3.05372559
103nucleus organization (GO:0006997)3.04968588
104polyol catabolic process (GO:0046174)3.04734813
105cellular extravasation (GO:0045123)3.04696793
106angiogenesis involved in wound healing (GO:0060055)3.02452450
107microtubule-based movement (GO:0007018)3.00937932
108intraciliary transport (GO:0042073)3.00689983
109synapsis (GO:0007129)2.99665936
110positive regulation of macrophage differentiation (GO:0045651)2.98241837
111mast cell activation (GO:0045576)2.98107686
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97565921
113peptide catabolic process (GO:0043171)2.97396656
114negative regulation of organelle assembly (GO:1902116)2.97135588
115detection of bacterium (GO:0016045)2.96808918
116antigen processing and presentation of endogenous antigen (GO:0019883)2.96658675
117positive regulation of gamma-delta T cell activation (GO:0046645)2.96610388
118interferon-gamma secretion (GO:0072643)2.95388125
119alditol metabolic process (GO:0019400)2.94395180
120meiotic cell cycle process (GO:1903046)2.93812140
121cilium assembly (GO:0042384)2.92190070
122sequestering of actin monomers (GO:0042989)2.90256849
123thrombin receptor signaling pathway (GO:0070493)2.90008254
124lactate metabolic process (GO:0006089)2.88740625
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87563628
126GTP biosynthetic process (GO:0006183)2.87363775
127cellular component assembly involved in morphogenesis (GO:0010927)2.85295988
128positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85185014
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83029428
130cilium morphogenesis (GO:0060271)2.82137351
131detection of molecule of bacterial origin (GO:0032490)2.81053823
132gene silencing by RNA (GO:0031047)2.81053050
133RNA localization (GO:0006403)2.79629906
134axoneme assembly (GO:0035082)2.79162636
135leukocyte aggregation (GO:0070486)2.78544849
136microglial cell activation (GO:0001774)2.76470553
137peptidyl-glutamic acid modification (GO:0018200)2.76458960
138regulated secretory pathway (GO:0045055)2.75576186
139glycosphingolipid catabolic process (GO:0046479)2.75499899
140positive regulation of type 2 immune response (GO:0002830)2.74999622
141detection of external biotic stimulus (GO:0098581)2.74684130
142RNA destabilization (GO:0050779)2.73983029
143response to thyroid hormone (GO:0097066)2.73211282
144regulation of regulated secretory pathway (GO:1903305)2.72569944
145B cell mediated immunity (GO:0019724)2.72297048
146G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71725534
147pinocytosis (GO:0006907)2.70102838
148negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69269953
149platelet aggregation (GO:0070527)2.69105523
150macrophage activation (GO:0042116)2.69047752
151regulation of T cell mediated cytotoxicity (GO:0001914)2.68872591
152positive regulation of interleukin-17 production (GO:0032740)2.68797184
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.66268953
154response to muramyl dipeptide (GO:0032495)2.66158753
155myeloid leukocyte activation (GO:0002274)2.65925673
156regulation of interferon-beta biosynthetic process (GO:0045357)2.65404180
157regulation of superoxide anion generation (GO:0032928)2.65208522
158positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63018266
159positive regulation of monocyte chemotaxis (GO:0090026)2.62765962
160positive regulation of macrophage activation (GO:0043032)2.60999346
161negative regulation of platelet activation (GO:0010544)2.58788099
162protein localization to endosome (GO:0036010)2.58596745
163mast cell degranulation (GO:0043303)2.57490712
164mast cell activation involved in immune response (GO:0002279)2.57490712
165regulation of cilium assembly (GO:1902017)2.55975143
166negative regulation of skeletal muscle tissue development (GO:0048642)2.55899912
167UTP biosynthetic process (GO:0006228)2.55205798
168purinergic receptor signaling pathway (GO:0035587)2.54658159
169response to host immune response (GO:0052572)2.54595681
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54595681
171positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52647244
172positive regulation of regulated secretory pathway (GO:1903307)2.51885431
173nuclear pore complex assembly (GO:0051292)2.51387042
174amino sugar catabolic process (GO:0046348)2.49969244
175detection of biotic stimulus (GO:0009595)2.49937374
176antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49409282
177membrane raft organization (GO:0031579)2.48409859
178positive regulation of interleukin-6 production (GO:0032755)2.47889127
179regulation of centriole replication (GO:0046599)2.47354980
180positive regulation of tumor necrosis factor production (GO:0032760)2.47280668
181phagocytosis, engulfment (GO:0006911)2.46263608
182hypotonic response (GO:0006971)2.46128760
183NIK/NF-kappaB signaling (GO:0038061)2.45543329
184positive regulation of isotype switching (GO:0045830)2.44499612
185regulation of homotypic cell-cell adhesion (GO:0034110)2.44392371
186* sperm motility (GO:0030317)13.9457895
187acrosome reaction (GO:0007340)12.4491811
188cell wall macromolecule catabolic process (GO:0016998)12.0758013
189cell wall macromolecule metabolic process (GO:0044036)12.0758013
190acrosome assembly (GO:0001675)11.9882942
191* fusion of sperm to egg plasma membrane (GO:0007342)11.6702163
192* sperm-egg recognition (GO:0035036)11.4983320
193cilium or flagellum-dependent cell motility (GO:0001539)10.8284662
194binding of sperm to zona pellucida (GO:0007339)10.8095506
195* multicellular organism reproduction (GO:0032504)10.6629683
196axonemal dynein complex assembly (GO:0070286)10.6307173
197epithelial cilium movement (GO:0003351)10.3294799
198* cell-cell recognition (GO:0009988)10.2705521
199spermatid development (GO:0007286)10.0213686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.39140376
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.53125140
3EZH2_22144423_ChIP-Seq_EOC_Human4.45862165
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.74289917
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.26837051
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.17570935
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16918093
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93805797
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87924124
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79614337
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73197709
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67579220
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64893307
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.54728557
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53087262
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48919371
17SPI1_23127762_ChIP-Seq_K562_Human2.48005268
18VDR_22108803_ChIP-Seq_LS180_Human2.47962395
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.31160257
20SCL_19346495_ChIP-Seq_HPC-7_Human2.25647233
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20293607
22VDR_24763502_ChIP-Seq_THP-1_Human2.19639513
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19082564
24SPI1_23547873_ChIP-Seq_NB4_Human2.18759033
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17950117
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17155051
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.16462368
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15366724
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.11651545
30VDR_21846776_ChIP-Seq_THP-1_Human2.11231323
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09879277
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08980589
33GATA1_26923725_Chip-Seq_HPCs_Mouse2.05612855
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.04490513
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03415467
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.03094920
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.02959699
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01416207
39FLI1_27457419_Chip-Seq_LIVER_Mouse2.00850686
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99900864
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98948766
42ZNF274_21170338_ChIP-Seq_K562_Hela1.97273041
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.90666098
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87819114
45LXR_22292898_ChIP-Seq_THP-1_Human1.85920398
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83268604
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82598236
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79427242
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78353770
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76521701
51MAF_26560356_Chip-Seq_TH1_Human1.75982220
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72140889
53STAT1_17558387_ChIP-Seq_HELA_Human1.71658156
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70984189
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70044568
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68944980
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68530660
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.65747419
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64441552
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63262876
61UTX_26944678_Chip-Seq_JUKART_Human1.62833602
62* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61374202
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59558294
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.58706665
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58295801
66* BCL6_27268052_Chip-Seq_Bcells_Human1.58264950
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57572917
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57274245
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57008904
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54652641
71* BCOR_27268052_Chip-Seq_Bcells_Human1.53676039
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.53362001
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52175469
74CBP_20019798_ChIP-Seq_JUKART_Human1.51824521
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51824521
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.51434572
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50734441
78GATA1_19941826_ChIP-Seq_K562_Human1.50182769
79MYB_26560356_Chip-Seq_TH2_Human1.49297462
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.48825759
81KDM2B_26808549_Chip-Seq_REH_Human1.47651705
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46745905
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45867959
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45306177
85RUNX_20019798_ChIP-Seq_JUKART_Human1.44504558
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.44303867
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.44300982
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42970284
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42580120
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42275073
91MAF_26560356_Chip-Seq_TH2_Human1.39872595
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39773332
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39124218
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38018534
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.36341075
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36199853
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.34923318
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34014756
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33062664
100TCF7_22412390_ChIP-Seq_EML_Mouse1.32869155
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32465191
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32250313
103LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31207303
104FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31043339
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30268658
106VDR_24787735_ChIP-Seq_THP-1_Human1.29571364
107SPI1_20517297_ChIP-Seq_HL60_Human1.29183535
108P53_21459846_ChIP-Seq_SAOS-2_Human1.28442199
109NCOR1_26117541_ChIP-Seq_K562_Human1.28092694
110TFEB_21752829_ChIP-Seq_HELA_Human1.27739176
111REST_21632747_ChIP-Seq_MESCs_Mouse1.27398968
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.24529342
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23711896
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23640330
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23217620
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23000860
117MYC_22102868_ChIP-Seq_BL_Human1.22892872
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22078683
119MYB_26560356_Chip-Seq_TH1_Human1.21259703
120GF1_26923725_Chip-Seq_HPCs_Mouse1.20582438
121* GATA3_21867929_ChIP-Seq_TH1_Mouse1.20411868
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20151037
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19951324
124KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19592164
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19516431
126GATA2_19941826_ChIP-Seq_K562_Human1.19222066
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18907827
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18682536
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17540654
130RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16580873
131* P68_20966046_ChIP-Seq_HELA_Human1.16200475
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15958157
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15958157
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15880634
135STAT1_20625510_ChIP-Seq_HELA_Human1.15876997
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15795973
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15774139
138RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15425941
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15398746
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13782813
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13549763
142TAF15_26573619_Chip-Seq_HEK293_Human1.13318540
143* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12587841
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12301933
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12249004
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11843449
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11777888
148EGR1_19374776_ChIP-ChIP_THP-1_Human1.11718872
149VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10040797
150CRX_20693478_ChIP-Seq_RETINA_Mouse1.10009216
151SPI1_26923725_Chip-Seq_HPCs_Mouse1.09960407
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09634705
153NANOG_18555785_Chip-Seq_ESCs_Mouse1.09236188
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09216409
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08441655
156ATF3_27146783_Chip-Seq_COLON_Human1.07826198
157RNF2_27304074_Chip-Seq_NSC_Mouse1.05668966
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05331853
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04555312
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04090386
161SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03595062
162OCT4_18555785_Chip-Seq_ESCs_Mouse1.03431683
163NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00935146
164ESET_19884257_ChIP-Seq_ESCs_Mouse1.00457377
165EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00117756
166MYC_27129775_Chip-Seq_CORNEA_Mouse1.00045633
167* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99988731
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99259997
169P53_22387025_ChIP-Seq_ESCs_Mouse0.99233030
170RACK7_27058665_Chip-Seq_MCF-7_Human0.99090162
171RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98609927
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97576624
173RARA_24833708_ChIP-Seq_LIVER_Mouse0.96189554
174ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95801553
175OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95522302
176EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94471329
177GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94307696
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.94106049
179PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93965421
180EZH2_27294783_Chip-Seq_NPCs_Mouse0.93913001
181CMYC_18555785_Chip-Seq_ESCs_Mouse0.93537994
182SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92983590
183P300_18555785_Chip-Seq_ESCs_Mouse0.92447693
184KLF4_18555785_Chip-Seq_ESCs_Mouse0.92405042
185SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91596348
186ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91281827
187* ERG_20517297_ChIP-Seq_VCAP_Human0.90501187
188NFYB_21822215_ChIP-Seq_K562_Human0.90027537
189CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89944328
190NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89089344
191PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88449503
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87980124
193GF1B_26923725_Chip-Seq_HPCs_Mouse0.87827329
194LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87560946
195STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87545243
196SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87314346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.13977688
2MP0001929_abnormal_gametogenesis5.60888732
3MP0005464_abnormal_platelet_physiology4.53012766
4MP0008877_abnormal_DNA_methylation4.35028397
5MP0005058_abnormal_lysosome_morphology3.65214885
6MP0003436_decreased_susceptibility_to3.55915655
7MP0002210_abnormal_sex_determination3.48570541
8MP0003724_increased_susceptibility_to3.45635836
9* MP0002161_abnormal_fertility/fecundity3.33884739
10MP0001835_abnormal_antigen_presentation3.20381334
11MP0004510_myositis3.06455748
12MP0003303_peritoneal_inflammation2.99787936
13MP0001145_abnormal_male_reproductive2.95124699
14MP0005670_abnormal_white_adipose2.90260506
15MP0002148_abnormal_hypersensitivity_rea2.88601811
16MP0002653_abnormal_ependyma_morphology2.73207805
17MP0002419_abnormal_innate_immunity2.66733298
18MP0003191_abnormal_cellular_cholesterol2.64069959
19MP0000343_altered_response_to2.62325945
20MP0000653_abnormal_sex_gland2.55238549
21MP0005000_abnormal_immune_tolerance2.55219747
22MP0005671_abnormal_response_to2.46453116
23MP0006082_CNS_inflammation2.39525734
24MP0005025_abnormal_response_to2.29250858
25MP0009785_altered_susceptibility_to2.24543121
26MP0001533_abnormal_skeleton_physiology2.22048921
27MP0002723_abnormal_immune_serum2.14592335
28MP0002452_abnormal_antigen_presenting2.09733419
29MP0000685_abnormal_immune_system2.07726264
30MP0003828_pulmonary_edema2.00844693
31* MP0005410_abnormal_fertilization16.2076544
32MP0003075_altered_response_to1.99287464
33MP0005387_immune_system_phenotype1.92202863
34MP0001790_abnormal_immune_system1.92202863
35MP0008004_abnormal_stomach_pH1.91967509
36MP0005623_abnormal_meninges_morphology1.86728768
37MP0000858_altered_metastatic_potential1.85112526
38MP0001800_abnormal_humoral_immune1.84973204
39MP0004947_skin_inflammation1.84425802
40MP0002420_abnormal_adaptive_immunity1.83786509
41MP0003172_abnormal_lysosome_physiology1.83522513
42MP0001819_abnormal_immune_cell1.83492100
43MP0005083_abnormal_biliary_tract1.75511556
44MP0009840_abnormal_foam_cell1.74550417
45MP0003300_gastrointestinal_ulcer1.71819826
46MP0005451_abnormal_body_composition1.70894532
47MP0009764_decreased_sensitivity_to1.70490293
48MP0002998_abnormal_bone_remodeling1.69540961
49MP0001845_abnormal_inflammatory_respons1.65099873
50MP0000465_gastrointestinal_hemorrhage1.64477271
51MP0003646_muscle_fatigue1.57375080
52MP0001853_heart_inflammation1.56617300
53MP0002282_abnormal_trachea_morphology1.52984065
54MP0010155_abnormal_intestine_physiology1.52833759
55MP0003806_abnormal_nucleotide_metabolis1.52264438
56MP0002160_abnormal_reproductive_system1.50884529
57MP0003566_abnormal_cell_adhesion1.41343270
58MP0002398_abnormal_bone_marrow1.41258395
59MP0002877_abnormal_melanocyte_morpholog1.39801312
60MP0008469_abnormal_protein_level1.38879194
61MP0009333_abnormal_splenocyte_physiolog1.37923115
62MP0003656_abnormal_erythrocyte_physiolo1.36536364
63MP0000716_abnormal_immune_system1.35092781
64MP0005164_abnormal_response_to1.30796701
65MP0002132_abnormal_respiratory_system1.29458124
66MP0008260_abnormal_autophagy1.23304220
67MP0002429_abnormal_blood_cell1.23115095
68MP0004233_abnormal_muscle_weight1.21882707
69MP0005166_decreased_susceptibility_to1.20142729
70MP0002722_abnormal_immune_system1.19909626
71MP0000689_abnormal_spleen_morphology1.18523521
72MP0005165_increased_susceptibility_to1.16462728
73MP0001851_eye_inflammation1.16372897
74MP0003448_altered_tumor_morphology1.16340917
75MP0009046_muscle_twitch1.10106347
76MP0000249_abnormal_blood_vessel1.08627953
77MP0005310_abnormal_salivary_gland1.05977564
78MP0002332_abnormal_exercise_endurance1.05035271
79MP0003453_abnormal_keratinocyte_physiol1.02287676
80MP0009763_increased_sensitivity_to1.01772102
81MP0005647_abnormal_sex_gland1.00764949
82MP0005390_skeleton_phenotype0.99890810
83MP0001984_abnormal_olfaction0.99138415
84MP0003763_abnormal_thymus_physiology0.98730311
85MP0003091_abnormal_cell_migration0.96207247
86MP0008058_abnormal_DNA_repair0.95543476
87MP0008995_early_reproductive_senescence0.92812356
88MP0006054_spinal_hemorrhage0.91147935
89MP0001663_abnormal_digestive_system0.90531051
90MP0004883_abnormal_blood_vessel0.89357141
91MP0005023_abnormal_wound_healing0.87702933
92MP0001542_abnormal_bone_strength0.87106909
93MP0003795_abnormal_bone_structure0.84279439
94MP0003866_abnormal_defecation0.82086068
95MP0009765_abnormal_xenobiotic_induced0.81741548
96MP0003878_abnormal_ear_physiology0.81562146
97MP0005377_hearing/vestibular/ear_phenot0.81562146
98MP0003115_abnormal_respiratory_system0.80081216
99MP0008874_decreased_physiological_sensi0.79799258
100MP0003638_abnormal_response/metabolism_0.77224256
101MP0005167_abnormal_blood-brain_barrier0.76810678
102MP0005389_reproductive_system_phenotype0.75792261
103MP0000703_abnormal_thymus_morphology0.75712601
104* MP0001765_abnormal_ion_homeostasis0.74434663
105MP0003011_delayed_dark_adaptation0.66504723
106MP0005084_abnormal_gallbladder_morpholo0.64157509
107MP0005636_abnormal_mineral_homeostasis0.63736479
108MP0000750_abnormal_muscle_regeneration0.63175817
109MP0003950_abnormal_plasma_membrane0.62821385
110MP0005666_abnormal_adipose_tissue0.61410603
111MP0005584_abnormal_enzyme/coenzyme_acti0.60870348
112MP0001873_stomach_inflammation0.59375271
113MP0000920_abnormal_myelination0.57334508
114MP0000490_abnormal_crypts_of0.56630035
115MP0002928_abnormal_bile_duct0.56190531
116MP0000569_abnormal_digit_pigmentation0.55206538
117MP0001324_abnormal_eye_pigmentation0.53578813
118MP0002234_abnormal_pharynx_morphology0.53052990
119MP0004036_abnormal_muscle_relaxation0.52956111
120MP0000609_abnormal_liver_physiology0.52703852
121MP0010094_abnormal_chromosome_stability0.50763885
122MP0000358_abnormal_cell_content/0.50664524
123MP0001764_abnormal_homeostasis0.50551931
124MP0003699_abnormal_female_reproductive0.50278361
125MP0009278_abnormal_bone_marrow0.50238402
126MP0001545_abnormal_hematopoietic_system0.49758350
127MP0005397_hematopoietic_system_phenotyp0.49758350
128MP0001293_anophthalmia0.47939665
129MP0005253_abnormal_eye_physiology0.47448367
130MP0003329_amyloid_beta_deposits0.46923354
131MP0005551_abnormal_eye_electrophysiolog0.40590628
132MP0000534_abnormal_ureter_morphology0.40431275
133MP0009115_abnormal_fat_cell0.39198545
134MP0002269_muscular_atrophy0.38393648
135MP0008057_abnormal_DNA_replication0.35067012
136MP0005391_vision/eye_phenotype0.34909976
137MP0006036_abnormal_mitochondrial_physio0.34659511
138MP0003879_abnormal_hair_cell0.34551857
139MP0003786_premature_aging0.34380516
140MP0002736_abnormal_nociception_after0.33824321
141MP0003633_abnormal_nervous_system0.32883838
142MP0002295_abnormal_pulmonary_circulatio0.32360460
143MP0001119_abnormal_female_reproductive0.30291147
144MP0003942_abnormal_urinary_system0.29690863
145MP0004133_heterotaxia0.29651613
146MP0002971_abnormal_brown_adipose0.29497145
147MP0003111_abnormal_nucleus_morphology0.29243397
148MP0003787_abnormal_imprinting0.28020408
149MP0001727_abnormal_embryo_implantation0.26849276
150MP0008961_abnormal_basal_metabolism0.25561431
151MP0004019_abnormal_vitamin_homeostasis0.25310815
152MP0001730_embryonic_growth_arrest0.24996651
153MP0004811_abnormal_neuron_physiology0.24388419
154MP0008007_abnormal_cellular_replicative0.24069383
155MP0004742_abnormal_vestibular_system0.24053337
156MP0003631_nervous_system_phenotype0.24010158
157MP0003948_abnormal_gas_homeostasis0.23521428
158MP0003045_fibrosis0.23025560
159MP0000604_amyloidosis0.22936786
160MP0003861_abnormal_nervous_system0.22790912
161MP0005423_abnormal_somatic_nervous0.21650839
162MP0005375_adipose_tissue_phenotype0.20823776
163MP0000751_myopathy0.20820418
164MP0002152_abnormal_brain_morphology0.20795487
165MP0002169_no_abnormal_phenotype0.20234871
166MP0002873_normal_phenotype0.19987083
167MP0002139_abnormal_hepatobiliary_system0.17579752
168MP0004145_abnormal_muscle_electrophysio0.17210952
169MP0002102_abnormal_ear_morphology0.17174795
170MP0009697_abnormal_copulation0.16768652
171MP0006035_abnormal_mitochondrial_morpho0.16715466
172MP0002092_abnormal_eye_morphology0.16649023
173MP0000313_abnormal_cell_death0.16615348
174MP0002405_respiratory_system_inflammati0.16314090
175MP0008569_lethality_at_weaning0.16240061
176MP0001348_abnormal_lacrimal_gland0.15925972
177MP0001661_extended_life_span0.15787432
178MP0001986_abnormal_taste_sensitivity0.15616747
179MP0004808_abnormal_hematopoietic_stem0.15524013
180MP0001968_abnormal_touch/_nociception0.15515785
181MP0003959_abnormal_lean_body0.14577683
182MP0010307_abnormal_tumor_latency0.13721462
183MP0004270_analgesia0.13630115
184MP0004043_abnormal_pH_regulation0.13626772
185MP0002229_neurodegeneration0.13392414
186MP0005195_abnormal_posterior_eye0.13260722

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.45244038
2Abnormal respiratory motile cilium morphology (HP:0005938)9.26841662
3Abnormal respiratory epithelium morphology (HP:0012253)9.26841662
4Abnormal ciliary motility (HP:0012262)7.58554617
5Rhinitis (HP:0012384)7.58046160
6Chronic bronchitis (HP:0004469)7.23954562
7Nasal polyposis (HP:0100582)6.48731866
8* Infertility (HP:0000789)6.05511546
9Petechiae (HP:0000967)5.52272618
10Abnormality of the nasal mucosa (HP:0000433)5.35098282
11Prolonged bleeding time (HP:0003010)5.21327330
12Purpura (HP:0000979)5.02173341
13Abnormality of macrophages (HP:0004311)4.93002353
14Bronchitis (HP:0012387)4.79691742
15Abnormality of glycolipid metabolism (HP:0010969)4.71697688
16Abnormality of liposaccharide metabolism (HP:0010968)4.71697688
17Abnormality of glycosphingolipid metabolism (HP:0004343)4.71697688
18Menorrhagia (HP:0000132)4.57753189
19Bronchiectasis (HP:0002110)4.55166865
20Nephronophthisis (HP:0000090)4.38144522
21Abnormal platelet volume (HP:0011876)4.28540298
22Epistaxis (HP:0000421)4.25965518
23Eczematoid dermatitis (HP:0000976)4.20166199
24Increased mean platelet volume (HP:0011877)4.19693402
25Recurrent abscess formation (HP:0002722)4.02655907
26Recurrent bacterial skin infections (HP:0005406)3.79937765
27Stomatitis (HP:0010280)3.70249666
28Dysostosis multiplex (HP:0000943)3.69756669
29Myositis (HP:0100614)3.50886883
30Gingival bleeding (HP:0000225)3.48872744
31Recurrent sinusitis (HP:0011108)3.47048360
32Abnormal platelet function (HP:0011869)3.46788855
33Impaired platelet aggregation (HP:0003540)3.46788855
34Increased cerebral lipofuscin (HP:0011813)3.45200964
35Recurrent otitis media (HP:0000403)3.42399321
36Hepatosplenomegaly (HP:0001433)3.42247702
37Orchitis (HP:0100796)3.41183220
38Vacuolated lymphocytes (HP:0001922)3.39867099
39Amyloidosis (HP:0011034)3.38567932
40Elevated erythrocyte sedimentation rate (HP:0003565)3.31394092
41Abnormality of the renal medulla (HP:0100957)3.30836396
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20719065
43Recurrent bronchitis (HP:0002837)3.16849862
44Retrobulbar optic neuritis (HP:0100654)3.12444497
45Optic neuritis (HP:0100653)3.12444497
46Myocardial infarction (HP:0001658)3.03443778
47Chronic obstructive pulmonary disease (HP:0006510)3.01758353
48Obstructive lung disease (HP:0006536)3.01758353
49Tubulointerstitial nephritis (HP:0001970)2.92961236
50Impulsivity (HP:0100710)2.86440433
51Axonal loss (HP:0003447)2.85998020
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.80326749
53Spontaneous hematomas (HP:0007420)2.77957294
54Molar tooth sign on MRI (HP:0002419)2.73155343
55Abnormality of midbrain morphology (HP:0002418)2.73155343
56Tubular atrophy (HP:0000092)2.72049272
57Recurrent gram-negative bacterial infections (HP:0005420)2.62142732
58Mediastinal lymphadenopathy (HP:0100721)2.61379502
59Tubulointerstitial abnormality (HP:0001969)2.54816562
60Fatigue (HP:0012378)2.54075503
61Increased serum ferritin (HP:0003281)2.49635888
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48324957
63Gonadotropin excess (HP:0000837)2.47411144
64Azoospermia (HP:0000027)2.46845674
65Gingivitis (HP:0000230)2.46157099
66Episodic fever (HP:0001954)2.45520691
67Abnormal gallbladder physiology (HP:0012438)2.40214031
68Cholecystitis (HP:0001082)2.40214031
69Distal lower limb muscle weakness (HP:0009053)2.38830804
70Medial flaring of the eyebrow (HP:0010747)2.38069185
71Disinhibition (HP:0000734)2.37297124
72Arterial thrombosis (HP:0004420)2.28126612
73Dyschromatopsia (HP:0007641)2.25848513
74Recurrent skin infections (HP:0001581)2.25735935
75Vertebral compression fractures (HP:0002953)2.24735804
76Urticaria (HP:0001025)2.24605001
77Upper limb muscle weakness (HP:0003484)2.22472486
78Glomerulopathy (HP:0100820)2.17313732
79Distal lower limb amyotrophy (HP:0008944)2.16617828
80Recurrent fungal infections (HP:0002841)2.15655986
81Abnormality of polysaccharide metabolism (HP:0011012)2.15187117
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15187117
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15187117
84Abnormality of iron homeostasis (HP:0011031)2.14702170
85Systemic lupus erythematosus (HP:0002725)2.13385539
86Progressive neurologic deterioration (HP:0002344)2.11662365
87Pulmonary infiltrates (HP:0002113)2.09536771
88Tubulointerstitial fibrosis (HP:0005576)2.08752553
89Bruising susceptibility (HP:0000978)2.08178958
90Decreased central vision (HP:0007663)2.08123770
91Spastic tetraparesis (HP:0001285)2.07363200
92Encephalitis (HP:0002383)2.06211290
93Hypertensive crisis (HP:0100735)2.05068016
94Gastrointestinal infarctions (HP:0005244)2.04887573
95Severe visual impairment (HP:0001141)2.04319101
96Vasculitis (HP:0002633)2.04202197
97Abnormality of lateral ventricle (HP:0030047)2.03467860
98Urinary glycosaminoglycan excretion (HP:0003541)2.02667395
99Mucopolysacchariduria (HP:0008155)2.02667395
100Upper motor neuron abnormality (HP:0002127)2.02046170
101Pustule (HP:0200039)2.01961710
102Hypertriglyceridemia (HP:0002155)2.00842483
103Conjunctival telangiectasia (HP:0000524)2.00466702
104Absent/shortened dynein arms (HP:0200106)13.6689407
105Dynein arm defect of respiratory motile cilia (HP:0012255)13.6689407
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4546737
107Interstitial pulmonary disease (HP:0006530)1.99500010
108Keratoconjunctivitis sicca (HP:0001097)1.99222554
109Autoimmune thrombocytopenia (HP:0001973)1.98605756
110Postaxial foot polydactyly (HP:0001830)1.95751772
111Increased IgM level (HP:0003496)1.95587463
112Vertigo (HP:0002321)1.93425405
113Chest pain (HP:0100749)1.91699701
114Choroideremia (HP:0001139)1.91590573
115Polyneuropathy (HP:0001271)1.91134542
116Hyperlipoproteinemia (HP:0010980)1.90092998
117Abnormality of the common coagulation pathway (HP:0010990)1.88695159
118Polydipsia (HP:0001959)1.88577973
119Abnormal drinking behavior (HP:0030082)1.88577973
120Paralysis (HP:0003470)1.87751194
121Arthralgia (HP:0002829)1.87507003
122Congenital hepatic fibrosis (HP:0002612)1.87105742
123Thrombocytosis (HP:0001894)1.86308394
124Stage 5 chronic kidney disease (HP:0003774)1.85489532
125Keratoconjunctivitis (HP:0001096)1.85418661
126Spondylolisthesis (HP:0003302)1.85277440
127Pulmonary fibrosis (HP:0002206)1.84496732
128Joint swelling (HP:0001386)1.84047238
129Anorexia (HP:0002039)1.81881254
130Meningitis (HP:0001287)1.81794490
131* Abnormal spermatogenesis (HP:0008669)1.81455987
132Prolonged neonatal jaundice (HP:0006579)1.81163190
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81091430
134Heterotopia (HP:0002282)1.80349378
135Joint hemorrhage (HP:0005261)1.80079941
136Nuclear cataract (HP:0100018)1.79295280
137Mutism (HP:0002300)1.77979118
138Mucosal telangiectasiae (HP:0100579)1.77711875
139Abnormality of the renal cortex (HP:0011035)1.77050411
140Abnormal biliary tract physiology (HP:0012439)1.74158298
141Bile duct proliferation (HP:0001408)1.74158298
142Short ribs (HP:0000773)1.72309971
143Abnormality of the lower motor neuron (HP:0002366)1.67356529
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66517424
145Abnormality of renal excretion (HP:0011036)1.66128913
146Fibular hypoplasia (HP:0003038)1.65683364
147Bell-shaped thorax (HP:0001591)1.65658459
148Hemorrhage of the eye (HP:0011885)1.65054680
149Oculomotor apraxia (HP:0000657)1.62512894
150Absent frontal sinuses (HP:0002688)1.61085772
151J-shaped sella turcica (HP:0002680)1.56785973
152Abnormality of dentin (HP:0010299)1.54886908
153Deformed sella turcica (HP:0002681)1.54129703
154Abnormality of permanent molar morphology (HP:0011071)1.52869623
155Abnormality of the dental root (HP:0006486)1.52869623
156Taurodontia (HP:0000679)1.52869623
157Renal dysplasia (HP:0000110)1.49560037
158Facial cleft (HP:0002006)1.48789002
159Postaxial hand polydactyly (HP:0001162)1.47702920
160Microglossia (HP:0000171)1.46041425
161Asymmetric septal hypertrophy (HP:0001670)1.45794675
162Neurofibrillary tangles (HP:0002185)1.45279875
163Decreased electroretinogram (ERG) amplitude (HP:0000654)1.44822881
164Cystic liver disease (HP:0006706)1.43636053
165Abnormality of molar morphology (HP:0011070)1.42999388
166Abnormality of molar (HP:0011077)1.42999388
167Hemiparesis (HP:0001269)1.41413462
168Amyotrophic lateral sclerosis (HP:0007354)1.41130212
169Pancreatic fibrosis (HP:0100732)1.40614866
170Abnormality of the dental pulp (HP:0006479)1.40426147
171Abnormal urine output (HP:0012590)1.40268443
172Chronic sinusitis (HP:0011109)1.37181511
173Aplasia/Hypoplasia of the lens (HP:0008063)1.34113978
174Bundle branch block (HP:0011710)1.31836320
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30558480
176Absent epiphyses (HP:0010577)1.30558480
177Short thorax (HP:0010306)1.29348496
178Nephropathy (HP:0000112)1.28404078
179Median cleft lip (HP:0000161)1.27433968
180Impaired proprioception (HP:0010831)1.27284587
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.27084348
182Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.26691820
183Abnormality of saccadic eye movements (HP:0000570)1.24115614
184Constricted visual fields (HP:0001133)1.22899252
185Broad distal phalanx of finger (HP:0009836)1.21743204
186Cerebral inclusion bodies (HP:0100314)1.19811547
187Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19113294
188Pachygyria (HP:0001302)1.18880048
189Polyuria (HP:0000103)1.18310761
190Truncal obesity (HP:0001956)1.17249126
191Hypercholesterolemia (HP:0003124)1.17166812
192Abnormality of the sella turcica (HP:0002679)1.15551419
193Cerebellar dysplasia (HP:0007033)1.15333920
194Abnormality of ocular smooth pursuit (HP:0000617)1.15013311
195Loss of speech (HP:0002371)1.14282025
196Congenital primary aphakia (HP:0007707)1.14159917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.06379284
2PDK38.06379284
3TESK16.04355531
4PRKD35.76173424
5PDK25.27492778
6ICK4.39360010
7IRAK33.67133549
8NME22.76875693
9BLK2.64367427
10PTK2B2.46695238
11MAP2K32.29447919
12PNCK2.25547168
13SIK32.22233832
14WNK42.21908501
15ARAF2.15982137
16MAP3K32.15304419
17STK392.11804124
18TAOK32.11516962
19TAOK21.87192600
20PIM21.82761006
21ERN11.81306427
22BMX1.76558952
23STK381.74889302
24BMPR21.74655563
25MAP3K111.74636226
26NEK21.69823059
27IRAK41.66358633
28FGR1.63202417
29IKBKB1.61238121
30DYRK1B1.53387939
31TBK11.51513942
32MST1R1.47048933
33MAP3K141.45518105
34MATK1.44889031
35BTK1.42212902
36EPHB11.39847142
37FES1.38770528
38MOS1.34628194
39MAP3K131.30430596
40SYK1.27228452
41EPHA21.27117901
42MAP4K11.22189179
43MYLK1.18967783
44LIMK11.18624672
45ILK1.18287766
46HCK1.17941897
47JAK31.12954996
48GRK71.12553021
49PRPF4B1.11739402
50ABL21.10969977
51PDK11.10955545
52TGFBR21.09912555
53TXK1.06452465
54GRK61.06338468
55PIK3CG1.04505953
56TYK21.02243517
57TRPM71.00805815
58MST40.98815816
59MAPK150.96536277
60TYRO30.95510939
61DDR20.94522028
62MAP3K10.90829364
63DYRK30.89964532
64LYN0.88864276
65TEC0.86908354
66WNK10.85704751
67JAK10.78116070
68BCKDK0.77428888
69EIF2AK10.75493395
70PASK0.68483710
71PRKD20.68359670
72TTK0.68048884
73STK30.67984021
74SIK10.67225072
75CAMK1G0.66905169
76PDPK10.65072848
77IKBKE0.63460718
78KIT0.62490462
79LCK0.61611580
80TNK20.60288197
81MAP2K60.59104299
82RIPK40.57844226
83EEF2K0.57029735
84CHEK20.56978237
85CCNB10.56769589
86LMTK20.56649870
87MAPKAPK30.56072633
88MAPKAPK20.55614412
89IRAK10.50941279
90TESK20.50248806
91CAMKK20.47789872
92SIK20.46025079
93STK38L0.44131825
94JAK20.43800927
95RAF10.43470494
96TTN0.43368585
97MAP3K50.43277287
98PAK10.42459199
99CHEK10.42294948
100PINK10.41810221
101STK160.41470397
102MAP3K80.38260148
103LRRK20.37506745
104FYN0.35979645
105DAPK10.34955139
106MUSK0.34442588
107EPHB20.34328422
108WEE10.34255477
109MAP3K120.34213576
110PRKCG0.33941454
111NTRK20.33242516
112PAK20.32264786
113PRKD10.31756954
114EPHA30.30828958
115ITK0.30117945
116HIPK20.29619818
117DAPK30.29610447
118RPS6KA20.29308665
119ATM0.29251812
120MTOR0.28017740
121NEK60.26841459
122ATR0.26557190
123IRAK20.25409602
124MAPKAPK50.24464248
125MARK20.23559481
126PAK40.22089165
127PRKAA10.20134917
128BRSK20.20019805
129CDC70.19634780
130MAP3K100.19413600
131CAMKK10.19133068
132RPS6KB10.15233625
133PLK10.14109742
134PLK40.13569120
135PRKCZ0.13275323
136PRKG20.12586080
137PRKCQ0.10783197
138ZAP700.09345759
139BRSK10.08769452
140CDK60.08279839
141GSK3B0.07518373
142CDK150.07114250
143CSNK1D0.07030120
144CSNK2A10.06409858
145STK110.05538395
146RPS6KA10.05510352
147TAOK10.05263700
148CDK180.04635980
149PRKG10.04418214
150CDK11A0.04397832
151CDK20.04298107
152CDK10.04064093
153PKN10.03501951
154PRKACG0.03501008
155CSNK2A20.03481802
156CAMK2A0.02957032
157MAPK80.02906679
158PRKCD0.02558932
159STK100.02208186
160BRAF0.02071103
161MARK30.02067683
162PRKCB0.01859572
163CDK40.01534782
164CDK120.01081556
165CDK140.00335883
166PDGFRB0.00264826
167PRKCA0.00255806
168PRKACB-0.0258314
169PRKACA-0.0215166
170RPS6KA3-0.0171166
171PIM1-0.0131412
172PRKDC-0.0117057
173CSK-0.0115812
174WNK3-0.0089845
175EGFR-0.0080145
176MAP3K4-0.0078633
177MAP2K7-0.0048097
178CSF1R-0.0028327

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.53623681
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51642196
3Vitamin B6 metabolism_Homo sapiens_hsa007503.53871544
4Pyruvate metabolism_Homo sapiens_hsa006203.53712753
5Other glycan degradation_Homo sapiens_hsa005113.01988696
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.00241195
7Linoleic acid metabolism_Homo sapiens_hsa005912.87395232
8Propanoate metabolism_Homo sapiens_hsa006402.79554675
9Osteoclast differentiation_Homo sapiens_hsa043802.63435294
10Glucagon signaling pathway_Homo sapiens_hsa049222.61568597
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.59772505
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.50796466
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38504968
14Lysosome_Homo sapiens_hsa041422.37253528
15Leishmaniasis_Homo sapiens_hsa051402.31301538
16Basal transcription factors_Homo sapiens_hsa030222.19229560
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16169498
18Malaria_Homo sapiens_hsa051442.13041056
19Staphylococcus aureus infection_Homo sapiens_hsa051502.04339552
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02317035
21Glycerolipid metabolism_Homo sapiens_hsa005611.98005188
22Tuberculosis_Homo sapiens_hsa051521.95122010
23Platelet activation_Homo sapiens_hsa046111.94358130
24Hematopoietic cell lineage_Homo sapiens_hsa046401.93759513
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.93292233
26PPAR signaling pathway_Homo sapiens_hsa033201.91489966
27Graft-versus-host disease_Homo sapiens_hsa053321.89052370
28Allograft rejection_Homo sapiens_hsa053301.86135605
29Pentose phosphate pathway_Homo sapiens_hsa000301.85256005
30Dorso-ventral axis formation_Homo sapiens_hsa043201.84688546
31Selenocompound metabolism_Homo sapiens_hsa004501.81475155
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.75865025
33Rheumatoid arthritis_Homo sapiens_hsa053231.75366334
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73926031
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.72465432
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71392505
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70916093
38Phagosome_Homo sapiens_hsa041451.69086298
39Oocyte meiosis_Homo sapiens_hsa041141.65080325
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.64467305
41Shigellosis_Homo sapiens_hsa051311.61881176
42Fructose and mannose metabolism_Homo sapiens_hsa000511.60451171
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56957968
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53821721
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52110718
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.51990470
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50760437
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.50342720
49Mineral absorption_Homo sapiens_hsa049781.49015936
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48847401
51Amphetamine addiction_Homo sapiens_hsa050311.47217602
52Pertussis_Homo sapiens_hsa051331.45776331
53Fanconi anemia pathway_Homo sapiens_hsa034601.43834398
54Autoimmune thyroid disease_Homo sapiens_hsa053201.43436099
55Fatty acid degradation_Homo sapiens_hsa000711.42005624
56Toxoplasmosis_Homo sapiens_hsa051451.41233725
57Fatty acid metabolism_Homo sapiens_hsa012121.40949925
58Carbon metabolism_Homo sapiens_hsa012001.36863418
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35961434
60Chemokine signaling pathway_Homo sapiens_hsa040621.34296385
61Viral myocarditis_Homo sapiens_hsa054161.33724771
62Fat digestion and absorption_Homo sapiens_hsa049751.31967939
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31601512
64Cardiac muscle contraction_Homo sapiens_hsa042601.31406794
65TNF signaling pathway_Homo sapiens_hsa046681.31289374
66Influenza A_Homo sapiens_hsa051641.29836374
67Ether lipid metabolism_Homo sapiens_hsa005651.28851315
68Acute myeloid leukemia_Homo sapiens_hsa052211.26889116
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26207509
70Asthma_Homo sapiens_hsa053101.25301333
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25128222
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25094509
73Intestinal immune network for IgA production_Homo sapiens_hsa046721.23724332
74Apoptosis_Homo sapiens_hsa042101.23138359
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.20420671
76Huntingtons disease_Homo sapiens_hsa050161.17511941
77Renin secretion_Homo sapiens_hsa049241.16677430
78Antigen processing and presentation_Homo sapiens_hsa046121.16322023
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16183326
80Measles_Homo sapiens_hsa051621.08951866
81Type I diabetes mellitus_Homo sapiens_hsa049401.06886958
82Herpes simplex infection_Homo sapiens_hsa051681.05424084
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03883304
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03466022
85T cell receptor signaling pathway_Homo sapiens_hsa046601.03008238
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02779623
87Galactose metabolism_Homo sapiens_hsa000521.02585847
88African trypanosomiasis_Homo sapiens_hsa051431.02556084
89mRNA surveillance pathway_Homo sapiens_hsa030151.02339579
90Purine metabolism_Homo sapiens_hsa002300.97743965
91RNA transport_Homo sapiens_hsa030130.96528793
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93924022
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.91494497
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.89985968
95Biosynthesis of amino acids_Homo sapiens_hsa012300.89112402
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88393521
97Renin-angiotensin system_Homo sapiens_hsa046140.86755051
98Pancreatic cancer_Homo sapiens_hsa052120.85244643
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85059542
100Hepatitis B_Homo sapiens_hsa051610.83236810
101Insulin secretion_Homo sapiens_hsa049110.82209862
102Estrogen signaling pathway_Homo sapiens_hsa049150.81173432
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.80382884
104Glutathione metabolism_Homo sapiens_hsa004800.78561494
105Primary immunodeficiency_Homo sapiens_hsa053400.78542427
106Bile secretion_Homo sapiens_hsa049760.75747261
107Bladder cancer_Homo sapiens_hsa052190.75419989
108Hedgehog signaling pathway_Homo sapiens_hsa043400.75102024
109Thyroid hormone synthesis_Homo sapiens_hsa049180.74764440
110Chemical carcinogenesis_Homo sapiens_hsa052040.72767087
111Amoebiasis_Homo sapiens_hsa051460.72184408
112Long-term potentiation_Homo sapiens_hsa047200.70671596
113Arachidonic acid metabolism_Homo sapiens_hsa005900.69755027
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69006334
115Collecting duct acid secretion_Homo sapiens_hsa049660.68969695
116Non-small cell lung cancer_Homo sapiens_hsa052230.68877594
117Viral carcinogenesis_Homo sapiens_hsa052030.66323662
118Legionellosis_Homo sapiens_hsa051340.64745350
119Epstein-Barr virus infection_Homo sapiens_hsa051690.62165134
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.59664672
121ABC transporters_Homo sapiens_hsa020100.57470327
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57427262
123Calcium signaling pathway_Homo sapiens_hsa040200.57125264
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56926044
125Chronic myeloid leukemia_Homo sapiens_hsa052200.56470348
126Hepatitis C_Homo sapiens_hsa051600.55995151
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55778571
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55154658
129Vibrio cholerae infection_Homo sapiens_hsa051100.52871789
130Salivary secretion_Homo sapiens_hsa049700.51972967
131Pancreatic secretion_Homo sapiens_hsa049720.51894146
132Protein digestion and absorption_Homo sapiens_hsa049740.51852758
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.50671452
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50128259
135Endocytosis_Homo sapiens_hsa041440.48593206
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47566779
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46387322
138Inositol phosphate metabolism_Homo sapiens_hsa005620.46283791
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.44637174
140Taste transduction_Homo sapiens_hsa047420.43171869
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.42709065
142AMPK signaling pathway_Homo sapiens_hsa041520.42006631
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40761419
144Gastric acid secretion_Homo sapiens_hsa049710.40303394
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39938469
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39316661
147Systemic lupus erythematosus_Homo sapiens_hsa053220.36918656
148Prion diseases_Homo sapiens_hsa050200.36563023
149VEGF signaling pathway_Homo sapiens_hsa043700.35429841
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35249182
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35161980
152Synaptic vesicle cycle_Homo sapiens_hsa047210.33970784
153Metabolic pathways_Homo sapiens_hsa011000.33697200
154Renal cell carcinoma_Homo sapiens_hsa052110.33602418
155Circadian entrainment_Homo sapiens_hsa047130.33390033
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32821987
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.32522286
158HTLV-I infection_Homo sapiens_hsa051660.32452368
159Complement and coagulation cascades_Homo sapiens_hsa046100.32063300
160Sphingolipid metabolism_Homo sapiens_hsa006000.31175727
161Focal adhesion_Homo sapiens_hsa045100.31081314
162cAMP signaling pathway_Homo sapiens_hsa040240.30989337
163Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29871346
164Sulfur metabolism_Homo sapiens_hsa009200.26382005
165Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20641870
166Cocaine addiction_Homo sapiens_hsa050300.17668319
167Pyrimidine metabolism_Homo sapiens_hsa002400.16615929
168Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14537675
169Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14401303
170Alcoholism_Homo sapiens_hsa050340.13827703
171HIF-1 signaling pathway_Homo sapiens_hsa040660.10391118
172Salmonella infection_Homo sapiens_hsa051320.10034030
173B cell receptor signaling pathway_Homo sapiens_hsa046620.08813385
174Type II diabetes mellitus_Homo sapiens_hsa049300.07191195
175Glutamatergic synapse_Homo sapiens_hsa047240.06908302
176Wnt signaling pathway_Homo sapiens_hsa043100.04533236
177RNA degradation_Homo sapiens_hsa030180.04056535

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