CATSPER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcription originates upstream of this locus in diphosphoinositol pentakisphosphate kinase 1 pseudogene 1 and is represented by GeneID:110006325. Related pseudogenes are found next to this locus on chromosome 15 and on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.88322483
2epithelial cilium movement (GO:0003351)9.76626864
3binding of sperm to zona pellucida (GO:0007339)9.58425370
4* cell-cell recognition (GO:0009988)9.46067230
5piRNA metabolic process (GO:0034587)9.22558693
6* reproduction (GO:0000003)8.85984578
7motile cilium assembly (GO:0044458)8.75691864
8male meiosis (GO:0007140)8.70456369
9spermatid development (GO:0007286)8.65994421
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.63278998
11cilium movement (GO:0003341)8.46044109
12regulation of cilium movement (GO:0003352)8.20091495
13sperm capacitation (GO:0048240)7.71880351
14synaptonemal complex organization (GO:0070193)7.55558169
15* single fertilization (GO:0007338)7.31571385
16synaptonemal complex assembly (GO:0007130)7.27230054
17* fertilization (GO:0009566)6.19497102
18DNA methylation involved in gamete generation (GO:0043046)5.72193588
19negative regulation of inclusion body assembly (GO:0090084)5.68363205
20* spermatogenesis (GO:0007283)5.47521199
21male meiosis I (GO:0007141)5.47241110
22microtubule severing (GO:0051013)5.46834302
23* male gamete generation (GO:0048232)5.45494974
24behavioral response to nicotine (GO:0035095)5.39677212
25ventricular system development (GO:0021591)5.38213209
26organic cation transport (GO:0015695)5.16964105
27chromosome organization involved in meiosis (GO:0070192)5.05807151
28* gamete generation (GO:0007276)5.02407251
29cellular process involved in reproduction in multicellular organism (GO:0022412)4.98108309
30protein polyglutamylation (GO:0018095)4.94304949
31germ cell development (GO:0007281)4.86040202
32regulation of microtubule-based movement (GO:0060632)4.83483399
33microtubule depolymerization (GO:0007019)4.80638737
34calcium ion-dependent exocytosis (GO:0017156)4.75246678
35meiotic nuclear division (GO:0007126)4.71317560
36* cell recognition (GO:0008037)4.64367414
37regulation of inclusion body assembly (GO:0090083)4.59456197
38intraciliary transport (GO:0042073)4.59114920
39spermatid nucleus differentiation (GO:0007289)4.44864073
40protein localization to cilium (GO:0061512)4.42712379
41meiosis I (GO:0007127)4.36500385
42fucose catabolic process (GO:0019317)4.29852206
43L-fucose metabolic process (GO:0042354)4.29852206
44L-fucose catabolic process (GO:0042355)4.29852206
45tryptophan catabolic process (GO:0006569)4.07152147
46indole-containing compound catabolic process (GO:0042436)4.07152147
47indolalkylamine catabolic process (GO:0046218)4.07152147
48seminiferous tubule development (GO:0072520)4.05303885
49left/right pattern formation (GO:0060972)3.99697993
50monoubiquitinated protein deubiquitination (GO:0035520)3.97884093
51* multicellular organismal reproductive process (GO:0048609)3.90037655
52indolalkylamine metabolic process (GO:0006586)3.89453505
53kynurenine metabolic process (GO:0070189)3.86890600
54meiotic cell cycle (GO:0051321)3.81779851
55detection of light stimulus involved in visual perception (GO:0050908)3.78950516
56detection of light stimulus involved in sensory perception (GO:0050962)3.78950516
57axoneme assembly (GO:0035082)3.74761407
58glycerol ether metabolic process (GO:0006662)3.73321474
59cellular ketone body metabolic process (GO:0046950)3.72582572
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67435074
61genitalia morphogenesis (GO:0035112)3.60647493
62centriole replication (GO:0007099)3.59656030
63response to pheromone (GO:0019236)3.51866567
64tryptophan metabolic process (GO:0006568)3.49269865
65cilium organization (GO:0044782)3.45637763
66ether metabolic process (GO:0018904)3.44550317
67protein K11-linked deubiquitination (GO:0035871)3.37620482
68centriole assembly (GO:0098534)3.36317128
69cilium morphogenesis (GO:0060271)3.35252741
70cilium assembly (GO:0042384)3.34432530
71ketone body metabolic process (GO:1902224)3.30390917
72DNA deamination (GO:0045006)3.29999425
73microtubule-based movement (GO:0007018)3.26820602
74gamma-aminobutyric acid transport (GO:0015812)3.22356446
75cellular component assembly involved in morphogenesis (GO:0010927)3.21763517
76regulation of spindle checkpoint (GO:0090231)3.19702098
77lactate metabolic process (GO:0006089)3.18167891
78synapsis (GO:0007129)3.15362133
79neuronal action potential (GO:0019228)3.15036159
80microtubule polymerization or depolymerization (GO:0031109)3.14968054
81single strand break repair (GO:0000012)3.13643280
82peptidyl-glutamic acid modification (GO:0018200)3.12549349
83* multicellular organismal development (GO:0007275)3.10767336
84negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07982776
85carnitine transmembrane transport (GO:1902603)3.06093016
86indole-containing compound metabolic process (GO:0042430)3.04515490
87amino-acid betaine transport (GO:0015838)3.04429508
88carnitine transport (GO:0015879)3.04429508
89auditory receptor cell stereocilium organization (GO:0060088)3.04381835
90respiratory chain complex IV assembly (GO:0008535)3.02622647
91negative regulation of organelle assembly (GO:1902116)2.99805510
92regulation of action potential (GO:0098900)2.99507940
93neuronal action potential propagation (GO:0019227)2.95889843
94establishment of protein localization to Golgi (GO:0072600)2.95345267
95reflex (GO:0060004)2.89122058
96gene silencing by RNA (GO:0031047)2.88353690
97alditol metabolic process (GO:0019400)2.88110730
98preassembly of GPI anchor in ER membrane (GO:0016254)2.84946577
99meiotic cell cycle process (GO:1903046)2.84207555
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83584809
101behavioral response to ethanol (GO:0048149)2.82754363
102neural tube formation (GO:0001841)2.79846443
103nonmotile primary cilium assembly (GO:0035058)2.78652699
104cytochrome complex assembly (GO:0017004)2.78013308
105protein complex biogenesis (GO:0070271)2.77663193
106cellular biogenic amine catabolic process (GO:0042402)2.77507268
107amine catabolic process (GO:0009310)2.77507268
108tachykinin receptor signaling pathway (GO:0007217)2.76734134
109negative regulation of mast cell activation (GO:0033004)2.76309871
110cAMP catabolic process (GO:0006198)2.76076740
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75842387
112photoreceptor cell maintenance (GO:0045494)2.75019825
113water-soluble vitamin biosynthetic process (GO:0042364)2.73339574
114polyol catabolic process (GO:0046174)2.71660059
115cellular response to ATP (GO:0071318)2.71220667
116sulfation (GO:0051923)2.70698968
117glycerol metabolic process (GO:0006071)2.68558618
118nucleoside diphosphate phosphorylation (GO:0006165)2.67005881
119primary amino compound metabolic process (GO:1901160)2.65302474
120dopamine transport (GO:0015872)2.65100129
121transmission of nerve impulse (GO:0019226)2.64026587
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63886931
123regulation of centriole replication (GO:0046599)2.63750632
124serotonin metabolic process (GO:0042428)2.63133860
125retinal cone cell development (GO:0046549)2.62796546
126* membrane depolarization during action potential (GO:0086010)2.62378853
127dendritic spine morphogenesis (GO:0060997)2.60538368
128rRNA catabolic process (GO:0016075)2.59959453
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58535496
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.58535496
131NADH dehydrogenase complex assembly (GO:0010257)2.58535496
132synaptic transmission, glutamatergic (GO:0035249)2.57661493
133cyclic nucleotide catabolic process (GO:0009214)2.56174262
134chaperone-mediated protein complex assembly (GO:0051131)2.55340034
135regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55328615
136regulation of meiosis I (GO:0060631)2.55039631
137proline transport (GO:0015824)2.54413796
138protein localization to Golgi apparatus (GO:0034067)2.54388044
139protein refolding (GO:0042026)2.54264211
140synaptic transmission, cholinergic (GO:0007271)2.54086476
141NAD biosynthetic process (GO:0009435)2.53688289
142axon ensheathment in central nervous system (GO:0032291)2.53678253
143central nervous system myelination (GO:0022010)2.53678253
144photoreceptor cell development (GO:0042461)2.53148040
145oxidative demethylation (GO:0070989)2.52882752
146rhodopsin mediated signaling pathway (GO:0016056)2.52596811
147negative regulation of skeletal muscle tissue development (GO:0048642)2.51570612
148aromatic amino acid family catabolic process (GO:0009074)2.51218642
149reciprocal DNA recombination (GO:0035825)2.50159139
150reciprocal meiotic recombination (GO:0007131)2.50159139
151nephron tubule morphogenesis (GO:0072078)2.47469691
152nephron epithelium morphogenesis (GO:0072088)2.47469691
153regulation of hexokinase activity (GO:1903299)2.47383419
154regulation of glucokinase activity (GO:0033131)2.47383419
155GTP biosynthetic process (GO:0006183)2.47108830
156positive regulation of fatty acid transport (GO:2000193)2.46849591
157regulation of response to osmotic stress (GO:0047484)2.46478369
158fucosylation (GO:0036065)2.46228734
159glycerophospholipid catabolic process (GO:0046475)2.46008136
160glutamate receptor signaling pathway (GO:0007215)2.45889393
161inositol phosphate catabolic process (GO:0071545)2.45324067
162signal peptide processing (GO:0006465)2.45074241
163mitochondrial respiratory chain complex assembly (GO:0033108)2.44259854
164benzene-containing compound metabolic process (GO:0042537)2.42560858
165platelet dense granule organization (GO:0060155)2.40648876
166inner ear receptor stereocilium organization (GO:0060122)2.40602334
167positive regulation of defense response to virus by host (GO:0002230)2.39381417
168startle response (GO:0001964)2.38842022
169single-organism membrane fusion (GO:0044801)2.37926268
170sexual reproduction (GO:0019953)2.28648492
171regulation of acrosome reaction (GO:0060046)2.25210995
172fatty acid elongation (GO:0030497)2.24420107
173nucleus organization (GO:0006997)2.24319208
174DNA packaging (GO:0006323)2.23795261
175organelle assembly (GO:0070925)2.22327805
176cilium or flagellum-dependent cell motility (GO:0001539)14.4749083
177fusion of sperm to egg plasma membrane (GO:0007342)13.0555697
178* sperm motility (GO:0030317)11.5687789
179acrosome assembly (GO:0001675)11.1648492
180* multicellular organism reproduction (GO:0032504)10.8318540
181cell wall macromolecule catabolic process (GO:0016998)10.7326909
182cell wall macromolecule metabolic process (GO:0044036)10.7326909
183* sperm-egg recognition (GO:0035036)10.6151400
184axonemal dynein complex assembly (GO:0070286)10.5485830
185acrosome reaction (GO:0007340)10.1590486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.27438781
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.41388937
3EZH2_22144423_ChIP-Seq_EOC_Human4.16544125
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.62004129
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58542943
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53217790
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.50428163
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48982027
9IGF1R_20145208_ChIP-Seq_DFB_Human2.46369000
10VDR_22108803_ChIP-Seq_LS180_Human2.41768964
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23543291
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.15998526
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09818821
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96901691
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95351759
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92388269
17RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.90970560
18EWS_26573619_Chip-Seq_HEK293_Human1.89408773
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.86643434
20P300_19829295_ChIP-Seq_ESCs_Human1.85370664
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74596936
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.73544051
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72961037
24TAL1_26923725_Chip-Seq_HPCs_Mouse1.70489257
25TAF15_26573619_Chip-Seq_HEK293_Human1.67231094
26STAT3_23295773_ChIP-Seq_U87_Human1.65987020
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63598676
28BCAT_22108803_ChIP-Seq_LS180_Human1.63377632
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.61707578
30ZNF274_21170338_ChIP-Seq_K562_Hela1.59426393
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.58398259
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.56505189
33TP53_22573176_ChIP-Seq_HFKS_Human1.53823954
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53700574
35CBP_20019798_ChIP-Seq_JUKART_Human1.53700574
36KDM2B_26808549_Chip-Seq_REH_Human1.53060316
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52760222
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.52552258
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50292547
40DROSHA_22980978_ChIP-Seq_HELA_Human1.49724166
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49033488
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48548540
43P53_22387025_ChIP-Seq_ESCs_Mouse1.47687897
44STAT1_17558387_ChIP-Seq_HELA_Human1.47524458
45P300_18555785_Chip-Seq_ESCs_Mouse1.46589980
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46264100
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.46007034
48AR_25329375_ChIP-Seq_VCAP_Human1.45589715
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.45352826
50SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44965230
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.43308822
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42680443
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.41689784
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41375488
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40876848
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40453777
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39587769
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.38844115
59* KLF4_18555785_Chip-Seq_ESCs_Mouse1.35002583
60RNF2_27304074_Chip-Seq_NSC_Mouse1.34178086
61AR_21572438_ChIP-Seq_LNCaP_Human1.34100227
62RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33921618
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.33762658
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33102019
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31432595
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.30781491
67ER_23166858_ChIP-Seq_MCF-7_Human1.30626179
68GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30097676
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29136653
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.27593901
71TCF4_22108803_ChIP-Seq_LS180_Human1.27142839
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26763304
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26480773
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26340280
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.25996656
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.25610020
77SOX2_19829295_ChIP-Seq_ESCs_Human1.25601088
78NANOG_19829295_ChIP-Seq_ESCs_Human1.25601088
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.24858825
80* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24823063
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23958022
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.23958022
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23309894
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23309894
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23250877
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22767757
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.22212661
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.21075494
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20853795
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.19956690
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19665266
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19656527
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19609057
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.19532840
95PU1_27457419_Chip-Seq_LIVER_Mouse1.18229502
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17327070
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.17170348
98IRF1_19129219_ChIP-ChIP_H3396_Human1.17085910
99* CTCF_18555785_Chip-Seq_ESCs_Mouse1.17052642
100* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16928013
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16623205
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.15043177
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.14805004
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13969219
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13869570
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13037397
107REST_21632747_ChIP-Seq_MESCs_Mouse1.12339620
108SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12285742
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11756756
110GATA3_21867929_ChIP-Seq_TH1_Mouse1.11322574
111GF1_26923725_Chip-Seq_HPCs_Mouse1.11033742
112WDR5_24793694_ChIP-Seq_LNCAP_Human1.09874668
113GATA3_21867929_ChIP-Seq_CD8_Mouse1.09276567
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.09172204
115* NCOR_22424771_ChIP-Seq_293T_Human1.09061967
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08110115
117FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07971398
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07720509
119TCF4_23295773_ChIP-Seq_U87_Human1.06355563
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06336342
121FUS_26573619_Chip-Seq_HEK293_Human1.06195113
122AR_20517297_ChIP-Seq_VCAP_Human1.04760286
123HOXB7_26014856_ChIP-Seq_BT474_Human1.04333850
124SOX9_26525672_Chip-Seq_HEART_Mouse1.03491779
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02691560
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01407645
127TP53_16413492_ChIP-PET_HCT116_Human1.00583110
128LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.99570270
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99505255
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99376352
131CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99171936
132SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98942994
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98855528
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98263528
135GBX2_23144817_ChIP-Seq_PC3_Human0.96981709
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96589963
137CDX2_22108803_ChIP-Seq_LS180_Human0.96579593
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96170623
139* MYC_19829295_ChIP-Seq_ESCs_Human0.95116989
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94997375
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94244895
142P53_21459846_ChIP-Seq_SAOS-2_Human0.94187239
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.94058405
144EZH2_27294783_Chip-Seq_ESCs_Mouse0.93143594
145GF1B_26923725_Chip-Seq_HPCs_Mouse0.92255865
146TBL1_22424771_ChIP-Seq_293T_Human0.90583836
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90407330
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89624715
149NFYB_21822215_ChIP-Seq_K562_Human0.89538821
150* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89124776
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88396228
152SMAD4_21799915_ChIP-Seq_A2780_Human0.87479730
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85639727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.57469938
2MP0001929_abnormal_gametogenesis5.05877398
3MP0008877_abnormal_DNA_methylation4.89868754
4MP0002210_abnormal_sex_determination3.46772086
5MP0002653_abnormal_ependyma_morphology3.39915933
6* MP0002161_abnormal_fertility/fecundity2.96149357
7MP0001145_abnormal_male_reproductive2.90090252
8MP0001968_abnormal_touch/_nociception2.65742277
9MP0000653_abnormal_sex_gland2.56154941
10MP0009745_abnormal_behavioral_response2.24941359
11MP0001501_abnormal_sleep_pattern2.23035450
12MP0008872_abnormal_physiological_respon2.13544267
13MP0002837_dystrophic_cardiac_calcinosis2.12145132
14* MP0005410_abnormal_fertilization14.1403852
15MP0002736_abnormal_nociception_after1.97344723
16MP0002735_abnormal_chemical_nociception1.93953461
17MP0002638_abnormal_pupillary_reflex1.92261812
18MP0003950_abnormal_plasma_membrane1.88078145
19MP0001984_abnormal_olfaction1.88044583
20MP0005623_abnormal_meninges_morphology1.81918423
21MP0008875_abnormal_xenobiotic_pharmacok1.78556792
22MP0006276_abnormal_autonomic_nervous1.78023584
23MP0009046_muscle_twitch1.77303783
24MP0006072_abnormal_retinal_apoptosis1.76806547
25MP0003635_abnormal_synaptic_transmissio1.62408725
26MP0002160_abnormal_reproductive_system1.59931672
27MP0006292_abnormal_olfactory_placode1.57495770
28MP0000920_abnormal_myelination1.53450153
29MP0005174_abnormal_tail_pigmentation1.52477608
30MP0001970_abnormal_pain_threshold1.51880379
31MP0000427_abnormal_hair_cycle1.51869363
32MP0002733_abnormal_thermal_nociception1.49930846
33MP0000372_irregular_coat_pigmentation1.48951713
34MP0002063_abnormal_learning/memory/cond1.46127964
35MP0004924_abnormal_behavior1.43861301
36MP0005386_behavior/neurological_phenoty1.43861301
37MP0004147_increased_porphyrin_level1.41562234
38MP0005670_abnormal_white_adipose1.40339865
39MP0008058_abnormal_DNA_repair1.34982017
40MP0002557_abnormal_social/conspecific_i1.34361732
41MP0008057_abnormal_DNA_replication1.30029145
42MP0004145_abnormal_muscle_electrophysio1.28090607
43MP0002067_abnormal_sensory_capabilities1.27498461
44MP0003136_yellow_coat_color1.20559109
45MP0004134_abnormal_chest_morphology1.19787566
46MP0002938_white_spotting1.16977043
47MP0002734_abnormal_mechanical_nocicepti1.16722669
48MP0003011_delayed_dark_adaptation1.13894114
49MP0001529_abnormal_vocalization1.13149547
50MP0005647_abnormal_sex_gland1.13010695
51MP0005084_abnormal_gallbladder_morpholo1.12864475
52MP0005551_abnormal_eye_electrophysiolog1.11161044
53MP0003646_muscle_fatigue1.08044996
54MP0010386_abnormal_urinary_bladder1.07720196
55MP0001502_abnormal_circadian_rhythm1.00079980
56MP0000566_synostosis0.99592465
57MP0002282_abnormal_trachea_morphology0.98754933
58MP0001986_abnormal_taste_sensitivity0.98295106
59MP0005167_abnormal_blood-brain_barrier0.98226407
60MP0003045_fibrosis0.98083314
61MP0000230_abnormal_systemic_arterial0.96095033
62MP0000383_abnormal_hair_follicle0.93912524
63MP0002693_abnormal_pancreas_physiology0.93412197
64MP0003806_abnormal_nucleotide_metabolis0.93132237
65MP0004859_abnormal_synaptic_plasticity0.92038841
66MP0002184_abnormal_innervation0.90986306
67MP0002909_abnormal_adrenal_gland0.90792985
68MP0002102_abnormal_ear_morphology0.90615990
69MP0005171_absent_coat_pigmentation0.89809046
70MP0001765_abnormal_ion_homeostasis0.87812294
71MP0002822_catalepsy0.85755530
72MP0002095_abnormal_skin_pigmentation0.85176991
73MP0004043_abnormal_pH_regulation0.84373775
74MP0003787_abnormal_imprinting0.81739365
75MP0003718_maternal_effect0.80596903
76MP0002234_abnormal_pharynx_morphology0.79840090
77MP0001440_abnormal_grooming_behavior0.79595180
78MP0005451_abnormal_body_composition0.79538742
79MP0001919_abnormal_reproductive_system0.79445796
80MP0001764_abnormal_homeostasis0.79270569
81MP0005448_abnormal_energy_balance0.78745463
82MP0004233_abnormal_muscle_weight0.77735304
83MP0002882_abnormal_neuron_morphology0.76107395
84MP0005646_abnormal_pituitary_gland0.75940017
85MP0000026_abnormal_inner_ear0.75323259
86MP0003878_abnormal_ear_physiology0.75074331
87MP0005377_hearing/vestibular/ear_phenot0.75074331
88MP0010329_abnormal_lipoprotein_level0.74356877
89MP0005379_endocrine/exocrine_gland_phen0.74154688
90MP0004215_abnormal_myocardial_fiber0.73667629
91MP0005253_abnormal_eye_physiology0.71610743
92MP0008260_abnormal_autophagy0.71258577
93MP0003121_genomic_imprinting0.70673746
94MP0005389_reproductive_system_phenotype0.69957747
95MP0009697_abnormal_copulation0.66848629
96MP0001293_anophthalmia0.66428995
97MP0001324_abnormal_eye_pigmentation0.65907863
98MP0005365_abnormal_bile_salt0.65653751
99MP0004742_abnormal_vestibular_system0.64213050
100MP0003329_amyloid_beta_deposits0.63903331
101MP0002928_abnormal_bile_duct0.62891843
102MP0002272_abnormal_nervous_system0.62106936
103MP0001661_extended_life_span0.61960997
104MP0008995_early_reproductive_senescence0.61804675
105MP0002229_neurodegeneration0.60559267
106MP0006036_abnormal_mitochondrial_physio0.58911859
107MP0005645_abnormal_hypothalamus_physiol0.57851722
108MP0003690_abnormal_glial_cell0.57305242
109MP0003634_abnormal_glial_cell0.56979497
110MP0004036_abnormal_muscle_relaxation0.56961153
111MP0004270_analgesia0.56148183
112MP0005423_abnormal_somatic_nervous0.56038377
113MP0001905_abnormal_dopamine_level0.55754660
114MP0004142_abnormal_muscle_tone0.55518327
115MP0003633_abnormal_nervous_system0.55194321
116MP0003631_nervous_system_phenotype0.55110232
117MP0001486_abnormal_startle_reflex0.54883752
118MP0002876_abnormal_thyroid_physiology0.54620196
119MP0003195_calcinosis0.53226445
120MP0005636_abnormal_mineral_homeostasis0.52728242
121MP0003880_abnormal_central_pattern0.51628863
122MP0003699_abnormal_female_reproductive0.48344032
123MP0005195_abnormal_posterior_eye0.48185045
124MP0002163_abnormal_gland_morphology0.48119953
125MP0000462_abnormal_digestive_system0.47633478
126MP0000569_abnormal_digit_pigmentation0.46435629
127MP0000015_abnormal_ear_pigmentation0.44332684
128MP0005408_hypopigmentation0.43947904
129MP0000778_abnormal_nervous_system0.43751558
130MP0003943_abnormal_hepatobiliary_system0.43004471
131MP0004133_heterotaxia0.42585031
132MP0010094_abnormal_chromosome_stability0.39640678
133MP0005391_vision/eye_phenotype0.38991917
134MP0003632_abnormal_nervous_system0.37459059
135MP0001119_abnormal_female_reproductive0.37298469
136MP0000358_abnormal_cell_content/0.36485800
137MP0001963_abnormal_hearing_physiology0.36485034
138MP0005409_darkened_coat_color0.35647541
139MP0006082_CNS_inflammation0.35366151
140MP0002752_abnormal_somatic_nervous0.34045008
141MP0002971_abnormal_brown_adipose0.33910433
142MP0004885_abnormal_endolymph0.33668188
143MP0003786_premature_aging0.32653170
144MP0005075_abnormal_melanosome_morpholog0.32613475
145MP0001485_abnormal_pinna_reflex0.32418463
146MP0002152_abnormal_brain_morphology0.32187369
147MP0002572_abnormal_emotion/affect_behav0.31707974
148MP0000631_abnormal_neuroendocrine_gland0.31621159
149MP0002064_seizures0.31110873
150MP0008569_lethality_at_weaning0.30942892
151MP0003183_abnormal_peptide_metabolism0.30405786
152MP0000647_abnormal_sebaceous_gland0.29520570
153MP0002118_abnormal_lipid_homeostasis0.29361642

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.87383900
2Abnormal respiratory epithelium morphology (HP:0012253)8.14804720
3Abnormal respiratory motile cilium morphology (HP:0005938)8.14804720
4Rhinitis (HP:0012384)7.34352765
5Abnormal ciliary motility (HP:0012262)7.25554031
6Chronic bronchitis (HP:0004469)6.76433954
7Infertility (HP:0000789)5.44652750
8Nasal polyposis (HP:0100582)5.35021406
9Nephronophthisis (HP:0000090)4.75905029
10Bronchiectasis (HP:0002110)4.35924713
11Bronchitis (HP:0012387)4.27806905
12Abnormality of the nasal mucosa (HP:0000433)4.22237760
13Congenital stationary night blindness (HP:0007642)4.00486245
14Abnormality of the renal medulla (HP:0100957)3.83910662
15Medial flaring of the eyebrow (HP:0010747)3.42353971
16Type II lissencephaly (HP:0007260)3.37771845
17Attenuation of retinal blood vessels (HP:0007843)3.25759833
18Tubulointerstitial nephritis (HP:0001970)3.19519538
19Recurrent sinusitis (HP:0011108)3.19459885
20Hyperventilation (HP:0002883)3.15607962
21Abnormal rod and cone electroretinograms (HP:0008323)3.15547140
22Recurrent otitis media (HP:0000403)3.06162270
23Molar tooth sign on MRI (HP:0002419)3.03620678
24Abnormality of midbrain morphology (HP:0002418)3.03620678
25Progressive cerebellar ataxia (HP:0002073)3.01904642
26Gaze-evoked nystagmus (HP:0000640)2.96101918
27Male infertility (HP:0003251)2.93233927
28Febrile seizures (HP:0002373)2.80824974
29Abnormal spermatogenesis (HP:0008669)2.80624873
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77866803
31Tubular atrophy (HP:0000092)2.76472998
32Genetic anticipation (HP:0003743)2.71775142
33Abolished electroretinogram (ERG) (HP:0000550)2.68157708
34Tubulointerstitial abnormality (HP:0001969)2.67545689
35Recurrent bronchitis (HP:0002837)2.62055538
36Cerebellar dysplasia (HP:0007033)2.61655574
37Abnormality of the renal cortex (HP:0011035)2.56819337
38Focal seizures (HP:0007359)2.51813287
39Decreased circulating renin level (HP:0003351)2.51437288
40Postaxial foot polydactyly (HP:0001830)2.49086000
41Broad-based gait (HP:0002136)2.48999126
42Gonadotropin excess (HP:0000837)2.43424899
43Focal motor seizures (HP:0011153)2.43267465
44Pancreatic fibrosis (HP:0100732)2.38753484
45Furrowed tongue (HP:0000221)2.33863459
46Protruding tongue (HP:0010808)2.33639364
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.31464364
48Absent speech (HP:0001344)2.29082866
49Renal cortical cysts (HP:0000803)2.25091813
50Hemiparesis (HP:0001269)2.22618250
51Congenital hepatic fibrosis (HP:0002612)2.21221221
52Bony spicule pigmentary retinopathy (HP:0007737)2.20437640
53Abnormal biliary tract physiology (HP:0012439)2.20296807
54Bile duct proliferation (HP:0001408)2.20296807
55Bell-shaped thorax (HP:0001591)2.20280433
56Abnormality of the pons (HP:0007361)2.19672942
57Abnormality of alanine metabolism (HP:0010916)2.19414642
58Hyperalaninemia (HP:0003348)2.19414642
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19414642
60Congenital primary aphakia (HP:0007707)2.18612083
61Sclerocornea (HP:0000647)2.17939662
62Gait imbalance (HP:0002141)2.16746938
63Lissencephaly (HP:0001339)2.16493742
64Large for gestational age (HP:0001520)2.16001504
65Inability to walk (HP:0002540)2.13277008
66Stomach cancer (HP:0012126)2.12656943
67Hypothermia (HP:0002045)2.12433257
68Fibular hypoplasia (HP:0003038)2.12120875
69Hypoplasia of the pons (HP:0012110)2.08892585
70J-shaped sella turcica (HP:0002680)2.08888079
71Clumsiness (HP:0002312)2.08715162
72Microglossia (HP:0000171)2.07088310
73Tubulointerstitial fibrosis (HP:0005576)2.06579596
74Polydipsia (HP:0001959)2.05845523
75Abnormal drinking behavior (HP:0030082)2.05845523
76Male pseudohermaphroditism (HP:0000037)2.05019011
77Anencephaly (HP:0002323)2.04922366
78Azoospermia (HP:0000027)2.04517682
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03950564
80Severe muscular hypotonia (HP:0006829)2.03828169
81Thyroiditis (HP:0100646)2.00044447
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3308473
83Absent/shortened dynein arms (HP:0200106)11.9955911
84Dynein arm defect of respiratory motile cilia (HP:0012255)11.9955911
85Mitochondrial inheritance (HP:0001427)1.99722463
86Increased CSF lactate (HP:0002490)1.99219218
87Nephrogenic diabetes insipidus (HP:0009806)1.98707936
88Decreased central vision (HP:0007663)1.97471702
89Pendular nystagmus (HP:0012043)1.96955341
903-Methylglutaconic aciduria (HP:0003535)1.96300367
91Renal dysplasia (HP:0000110)1.95428889
92Keratoconus (HP:0000563)1.95122028
93Increased corneal curvature (HP:0100692)1.95122028
94Fair hair (HP:0002286)1.93801255
95Impulsivity (HP:0100710)1.93707904
96Chronic hepatic failure (HP:0100626)1.91280028
97Dialeptic seizures (HP:0011146)1.90943519
98Congenital, generalized hypertrichosis (HP:0004540)1.90819748
99Stage 5 chronic kidney disease (HP:0003774)1.90313381
100Spastic tetraparesis (HP:0001285)1.89275136
101Pachygyria (HP:0001302)1.88750409
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.86381905
103Supernumerary spleens (HP:0009799)1.86378908
104Limb dystonia (HP:0002451)1.86366739
105Epileptic encephalopathy (HP:0200134)1.85287976
106Constricted visual fields (HP:0001133)1.85158772
107Postaxial hand polydactyly (HP:0001162)1.84934228
108Widely spaced teeth (HP:0000687)1.84904343
109Genital tract atresia (HP:0001827)1.84390031
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83716688
111Abnormality of macular pigmentation (HP:0008002)1.81277062
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81125989
113Retinal dysplasia (HP:0007973)1.81083682
114Ketosis (HP:0001946)1.79087020
115Vaginal atresia (HP:0000148)1.78727024
116Oculomotor apraxia (HP:0000657)1.78426780
117Progressive inability to walk (HP:0002505)1.78067549
118Ketoacidosis (HP:0001993)1.77192830
119Acute necrotizing encephalopathy (HP:0006965)1.75900562
120Progressive macrocephaly (HP:0004481)1.74664799
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.74599944
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74599944
123Optic disc pallor (HP:0000543)1.74334858
124Abnormality of renal excretion (HP:0011036)1.73418675
125Hepatocellular necrosis (HP:0001404)1.73107563
126True hermaphroditism (HP:0010459)1.72962362
127Congenital sensorineural hearing impairment (HP:0008527)1.72536905
128Agitation (HP:0000713)1.70339785
129Poor coordination (HP:0002370)1.69110679
130Nephropathy (HP:0000112)1.68744486
131Hepatic necrosis (HP:0002605)1.67846204
132Chronic sinusitis (HP:0011109)1.67098492
133Abnormality of the dental root (HP:0006486)1.64753505
134Taurodontia (HP:0000679)1.64753505
135Abnormality of permanent molar morphology (HP:0011071)1.64753505
136Cystic liver disease (HP:0006706)1.62791777
137Abnormality of saccadic eye movements (HP:0000570)1.60690416
138Impaired proprioception (HP:0010831)1.60429757
139Aplasia/Hypoplasia of the lens (HP:0008063)1.60320389
140Abnormality of the dental pulp (HP:0006479)1.60209022
141Dyschromatopsia (HP:0007641)1.59766384
142Neurofibrillary tangles (HP:0002185)1.56268422
143Pancreatic cysts (HP:0001737)1.56076876
144Abnormality of molar (HP:0011077)1.55110942
145Abnormality of molar morphology (HP:0011070)1.55110942
146Amyotrophic lateral sclerosis (HP:0007354)1.53747949
147Abnormality of dentin (HP:0010299)1.53516764
148Abnormality of the lower motor neuron (HP:0002366)1.52122301
149Absent frontal sinuses (HP:0002688)1.50185877
150Polyuria (HP:0000103)1.48487090
151Abnormal urine output (HP:0012590)1.48161609
152Short ribs (HP:0000773)1.47927417
153Cholecystitis (HP:0001082)1.46651918
154Abnormal gallbladder physiology (HP:0012438)1.46651918
155Absent epiphyses (HP:0010577)1.46308930
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46308930
157Median cleft lip (HP:0000161)1.44569613
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.41114860
159Sensory axonal neuropathy (HP:0003390)1.40313591
160Optic nerve hypoplasia (HP:0000609)1.38966741
161Aplasia/Hypoplasia of the fibula (HP:0006492)1.32311010
162Vascular calcification (HP:0004934)1.32276952
163Deformed sella turcica (HP:0002681)1.32225326
164Short thorax (HP:0010306)1.30232382
165Occipital encephalocele (HP:0002085)1.27020796
166Choroideremia (HP:0001139)1.26632743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.18497819
2PDK38.18497819
3FRK6.84332098
4PDK25.47477300
5STK394.06947622
6TESK13.91814688
7WNK43.31592226
8PRKD33.21176880
9ICK3.03888865
10PTK2B2.45187043
11MAP4K22.26280567
12GRK12.22969842
13MAPK132.09473142
14TLK12.00561867
15PNCK1.99326494
16DAPK21.91665925
17WNK11.61917394
18NTRK31.48920166
19PAK31.44057921
20MAPK151.43372144
21CAMKK21.38952187
22OXSR11.32463750
23MARK11.26748999
24BMPR1B1.20103664
25ADRBK11.19422291
26CCNB11.12796420
27PBK1.11409877
28NEK61.08301665
29PHKG11.05661215
30PHKG21.05661215
31MKNK20.98448208
32TNK20.97056988
33EPHA40.95816064
34KIT0.93693404
35PDK10.93396997
36IRAK10.92654632
37NTRK20.90506618
38BCR0.89079938
39PLK40.87263898
40STK380.87231735
41NEK20.84667968
42CSNK1G20.77692175
43CASK0.77265463
44DYRK20.74867148
45TGFBR10.74246723
46STK30.74110739
47PKN10.73007790
48MUSK0.71442500
49TEC0.70520739
50PASK0.69864362
51CSNK1G30.69830597
52CSNK1G10.69101152
53EPHB10.68848053
54STK110.66835304
55CSNK1A1L0.65600376
56CAMKK10.65400993
57BCKDK0.65349566
58CAMK10.64481712
59DYRK30.63694735
60IKBKB0.61559446
61DYRK1B0.59895407
62INSRR0.59681054
63SYK0.57449328
64PINK10.56986675
65ITK0.56084388
66TRIM280.54512173
67PDPK10.52820461
68CAMK1G0.51974284
69BRSK20.51806174
70MAP2K40.51611776
71PLK20.51080654
72SGK20.50826046
73EPHA30.50752790
74MAPKAPK30.49778603
75NLK0.49585661
76TYRO30.48964901
77SIK20.47942056
78TRPM70.47417735
79MAP2K60.46978427
80MAPKAPK50.46805496
81WNK30.46262100
82ATR0.45738338
83CDK190.45691024
84IRAK20.44772330
85PRKCH0.44604947
86CSNK1A10.44132721
87SGK10.43176158
88CHEK20.41725529
89PAK60.41546905
90PRKAA20.40622952
91TESK20.40201170
92PRKCI0.40136766
93MAP2K70.39267308
94MINK10.38304568
95STK38L0.38124503
96PRKCQ0.37944038
97VRK10.37357302
98PRKCA0.37267263
99LMTK20.37174360
100CHEK10.36645605
101CHUK0.35669124
102FER0.35580946
103NME10.34794176
104FGFR20.34586712
105CLK10.34316763
106FLT30.33806330
107YES10.33498693
108GRK50.32478622
109PIK3CG0.32466250
110ATM0.30222056
111BMPR20.29019794
112CAMK2G0.28734142
113OBSCN0.28524888
114TNIK0.28041598
115CDC70.27543117
116CAMK2A0.27509890
117MARK20.27315231
118BRAF0.26711881
119PRKG10.25771477
120PRKCG0.25623579
121CDK30.24890438
122PAK10.24640014
123CAMK2D0.23004356
124TTK0.21898858
125RPS6KB10.21526392
126ERBB30.21274917
127MET0.19931499
128SGK4940.19744671
129SGK2230.19744671
130ACVR1B0.18300629
131ZAK0.17817534
132CSF1R0.17677807
133PRKACB0.17459926
134ZAP700.15169258
135CAMK2B0.15106777
136MAP3K40.14879727
137CSNK1D0.14627675
138NUAK10.14456423
139AKT30.13628164
140STK160.12520208
141RPS6KA50.12294687
142GSK3B0.10578881
143TXK0.09607583
144MTOR0.09578642
145PRKAA10.09353109
146ADRBK20.09015997
147PIK3CA0.08952997
148CDK10.07250708
149PRKCE0.07167473
150PDGFRB0.06521955
151MAPK80.06447399
152PRKCZ0.06392054
153CSNK2A10.05379801
154PRKCD0.05235447
155PRKACA0.05196811
156TAOK30.05095613

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.15252084
2Pyruvate metabolism_Homo sapiens_hsa006203.86741055
3Propanoate metabolism_Homo sapiens_hsa006403.47392330
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.10414103
5Fatty acid biosynthesis_Homo sapiens_hsa000613.01296574
6Basal transcription factors_Homo sapiens_hsa030222.92373144
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75228413
8Nicotine addiction_Homo sapiens_hsa050332.68916811
9Linoleic acid metabolism_Homo sapiens_hsa005912.68601024
10Nitrogen metabolism_Homo sapiens_hsa009102.44316311
11Fatty acid elongation_Homo sapiens_hsa000622.32220442
12Butanoate metabolism_Homo sapiens_hsa006502.30421366
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26214084
14Pentose phosphate pathway_Homo sapiens_hsa000302.23804117
15Selenocompound metabolism_Homo sapiens_hsa004502.17338989
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.06693502
17Ether lipid metabolism_Homo sapiens_hsa005652.01910872
18Dorso-ventral axis formation_Homo sapiens_hsa043201.98126614
19Fanconi anemia pathway_Homo sapiens_hsa034601.93593929
20Caffeine metabolism_Homo sapiens_hsa002321.93440673
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88626652
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88231845
23Tryptophan metabolism_Homo sapiens_hsa003801.86516169
24Huntingtons disease_Homo sapiens_hsa050161.81819243
25Morphine addiction_Homo sapiens_hsa050321.80528794
26Fatty acid metabolism_Homo sapiens_hsa012121.78765944
27Steroid biosynthesis_Homo sapiens_hsa001001.78413901
28Glucagon signaling pathway_Homo sapiens_hsa049221.78290023
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75007481
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70493711
31Glycerolipid metabolism_Homo sapiens_hsa005611.66116823
32Circadian entrainment_Homo sapiens_hsa047131.54236633
33GABAergic synapse_Homo sapiens_hsa047271.50104915
34Protein export_Homo sapiens_hsa030601.47129797
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44900410
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43713131
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42994524
38Fatty acid degradation_Homo sapiens_hsa000711.41826644
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.41714876
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39177794
41PPAR signaling pathway_Homo sapiens_hsa033201.37772534
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36740380
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32969568
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27340529
45Serotonergic synapse_Homo sapiens_hsa047261.27076630
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.26779219
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24663914
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.23932657
49Salivary secretion_Homo sapiens_hsa049701.23243040
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20785009
51Cardiac muscle contraction_Homo sapiens_hsa042601.13958160
52Sulfur metabolism_Homo sapiens_hsa009201.12227772
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10328645
54Carbon metabolism_Homo sapiens_hsa012001.08386606
55Peroxisome_Homo sapiens_hsa041461.05909540
56ABC transporters_Homo sapiens_hsa020101.04838487
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01221069
58Ovarian steroidogenesis_Homo sapiens_hsa049131.01045374
59Regulation of autophagy_Homo sapiens_hsa041401.00710644
60Glutathione metabolism_Homo sapiens_hsa004801.00345225
61Purine metabolism_Homo sapiens_hsa002300.99992589
62RNA polymerase_Homo sapiens_hsa030200.97019896
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96866629
64Oocyte meiosis_Homo sapiens_hsa041140.96281525
65Arachidonic acid metabolism_Homo sapiens_hsa005900.95295990
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95216741
67Asthma_Homo sapiens_hsa053100.92082943
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91143524
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91078096
70Allograft rejection_Homo sapiens_hsa053300.90151192
71Amphetamine addiction_Homo sapiens_hsa050310.90114537
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89993013
73Dopaminergic synapse_Homo sapiens_hsa047280.85979393
74Primary immunodeficiency_Homo sapiens_hsa053400.84400777
75Chemical carcinogenesis_Homo sapiens_hsa052040.84228161
76beta-Alanine metabolism_Homo sapiens_hsa004100.81941174
77mRNA surveillance pathway_Homo sapiens_hsa030150.80870651
78Histidine metabolism_Homo sapiens_hsa003400.79145607
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.78725769
80Fructose and mannose metabolism_Homo sapiens_hsa000510.77751682
81Sphingolipid metabolism_Homo sapiens_hsa006000.75614526
82Cocaine addiction_Homo sapiens_hsa050300.73977717
83Cholinergic synapse_Homo sapiens_hsa047250.73794899
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73438860
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72966663
86Biosynthesis of amino acids_Homo sapiens_hsa012300.71694112
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71669321
88Metabolic pathways_Homo sapiens_hsa011000.70460696
89Long-term depression_Homo sapiens_hsa047300.69611859
90Renin secretion_Homo sapiens_hsa049240.69067561
91Circadian rhythm_Homo sapiens_hsa047100.68774671
92Mineral absorption_Homo sapiens_hsa049780.67958087
93Autoimmune thyroid disease_Homo sapiens_hsa053200.65757763
94One carbon pool by folate_Homo sapiens_hsa006700.64958875
95Synaptic vesicle cycle_Homo sapiens_hsa047210.64828619
96Retinol metabolism_Homo sapiens_hsa008300.64767613
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.64515582
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63283338
99cAMP signaling pathway_Homo sapiens_hsa040240.63059233
100Oxytocin signaling pathway_Homo sapiens_hsa049210.62571396
101Gastric acid secretion_Homo sapiens_hsa049710.62060655
102Non-homologous end-joining_Homo sapiens_hsa034500.61802621
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60736454
104Collecting duct acid secretion_Homo sapiens_hsa049660.59460393
105Fat digestion and absorption_Homo sapiens_hsa049750.59358754
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57394599
107Vitamin digestion and absorption_Homo sapiens_hsa049770.55115066
108Oxidative phosphorylation_Homo sapiens_hsa001900.53979987
109RNA degradation_Homo sapiens_hsa030180.53784699
110Taste transduction_Homo sapiens_hsa047420.53124659
111Homologous recombination_Homo sapiens_hsa034400.47598429
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47259056
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43916405
114Renin-angiotensin system_Homo sapiens_hsa046140.42697539
115Insulin secretion_Homo sapiens_hsa049110.41917417
116Antigen processing and presentation_Homo sapiens_hsa046120.41824879
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39523975
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38280118
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34665739
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32921634
121Graft-versus-host disease_Homo sapiens_hsa053320.31160502
122RNA transport_Homo sapiens_hsa030130.31041802
123Alzheimers disease_Homo sapiens_hsa050100.30917829
124Legionellosis_Homo sapiens_hsa051340.30768512
125Rheumatoid arthritis_Homo sapiens_hsa053230.27975070
126Type I diabetes mellitus_Homo sapiens_hsa049400.27178913
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26613139
128Calcium signaling pathway_Homo sapiens_hsa040200.25480744
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.24214184
130Proteasome_Homo sapiens_hsa030500.24210232
131N-Glycan biosynthesis_Homo sapiens_hsa005100.23468440
132Lysine degradation_Homo sapiens_hsa003100.23382591
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20887296
134Phototransduction_Homo sapiens_hsa047440.20238502
135Complement and coagulation cascades_Homo sapiens_hsa046100.18526468
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.18425137
137Pancreatic secretion_Homo sapiens_hsa049720.17655766
138Glutamatergic synapse_Homo sapiens_hsa047240.16922914
139Parkinsons disease_Homo sapiens_hsa050120.16847686
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15374447
141Olfactory transduction_Homo sapiens_hsa047400.14828675

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