CATSPER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.92638329
2epithelial cilium movement (GO:0003351)9.51883655
3spermatid development (GO:0007286)9.13552125
4motile cilium assembly (GO:0044458)8.68639094
5regulation of cilium movement (GO:0003352)8.44685850
6cilium movement (GO:0003341)8.27843767
7male meiosis (GO:0007140)8.15144324
8* single fertilization (GO:0007338)7.88313976
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.48534972
10piRNA metabolic process (GO:0034587)7.19404970
11synaptonemal complex organization (GO:0070193)7.06759552
12synaptonemal complex assembly (GO:0007130)7.03960736
13* sperm capacitation (GO:0048240)6.57865198
14* fertilization (GO:0009566)6.36317659
15organic cation transport (GO:0015695)6.02273097
16spermatid nucleus differentiation (GO:0007289)5.91767194
17spermatogenesis (GO:0007283)5.86095968
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.84639861
19male gamete generation (GO:0048232)5.83758762
20ventricular system development (GO:0021591)5.57612784
21microtubule depolymerization (GO:0007019)5.51620922
22mitotic metaphase plate congression (GO:0007080)5.49411784
23gamete generation (GO:0007276)5.38107227
24microtubule severing (GO:0051013)5.25624332
25calcium ion-dependent exocytosis (GO:0017156)5.21904958
26negative regulation of inclusion body assembly (GO:0090084)5.21144426
27* cellular process involved in reproduction in multicellular organism (GO:0022412)5.20846811
28* cell recognition (GO:0008037)5.19879178
29germ cell development (GO:0007281)5.01908014
30mitotic sister chromatid segregation (GO:0000070)4.96912502
31regulation of microtubule-based movement (GO:0060632)4.96851638
32regulation of inclusion body assembly (GO:0090083)4.93798407
33chromosome organization involved in meiosis (GO:0070192)4.89778799
34male meiosis I (GO:0007141)4.83806004
35metaphase plate congression (GO:0051310)4.81245072
36sister chromatid segregation (GO:0000819)4.63846693
37mitochondrion distribution (GO:0048311)4.62074540
38DNA methylation involved in gamete generation (GO:0043046)4.59526212
39meiotic nuclear division (GO:0007126)4.49580363
40positive regulation of mRNA processing (GO:0050685)4.48182808
41protein polyglutamylation (GO:0018095)4.45340098
42establishment of chromosome localization (GO:0051303)4.31755901
43multicellular organismal reproductive process (GO:0048609)4.22985350
44misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.15264454
45inner ear receptor cell differentiation (GO:0060113)4.09281404
46glycerol ether metabolic process (GO:0006662)4.00053358
47monoubiquitinated protein deubiquitination (GO:0035520)3.92593670
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.90695400
49positive regulation of mRNA metabolic process (GO:1903313)3.88774718
50positive regulation of mRNA 3-end processing (GO:0031442)3.86505851
51mitotic chromosome condensation (GO:0007076)3.84556006
52chaperone-mediated protein complex assembly (GO:0051131)3.82460753
53regulation of mitotic spindle organization (GO:0060236)3.82042662
54positive regulation of RNA splicing (GO:0033120)3.81985163
55genitalia morphogenesis (GO:0035112)3.79498837
56meiosis I (GO:0007127)3.78926438
57skeletal muscle adaptation (GO:0043501)3.78367079
58protein localization to kinetochore (GO:0034501)3.76490693
59DNA ligation (GO:0006266)3.74953067
60seminiferous tubule development (GO:0072520)3.72758044
61left/right pattern formation (GO:0060972)3.69936932
62actin-myosin filament sliding (GO:0033275)3.69055307
63muscle filament sliding (GO:0030049)3.69055307
64ether metabolic process (GO:0018904)3.69011944
65striated muscle atrophy (GO:0014891)3.67723681
66short-term memory (GO:0007614)3.65968222
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.62171394
68protein complex localization (GO:0031503)3.56371875
69protein localization to chromosome, centromeric region (GO:0071459)3.51296713
70regulation of spindle organization (GO:0090224)3.50590217
71negative regulation of potassium ion transmembrane transport (GO:1901380)3.50445133
72amino-acid betaine transport (GO:0015838)3.50121377
73carnitine transport (GO:0015879)3.50121377
74muscle atrophy (GO:0014889)3.49077919
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.48710455
76regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.47199281
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.47199281
78cell fate commitment involved in formation of primary germ layer (GO:0060795)3.46841610
79axoneme assembly (GO:0035082)3.45526733
80carnitine transmembrane transport (GO:1902603)3.42269722
81protein localization to cilium (GO:0061512)3.41620206
82ribosome assembly (GO:0042255)3.40912481
83* multicellular organismal development (GO:0007275)3.37610499
84lysine catabolic process (GO:0006554)3.33617474
85lysine metabolic process (GO:0006553)3.33617474
86regulation of mRNA 3-end processing (GO:0031440)3.33055273
87NADH metabolic process (GO:0006734)3.31659319
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.29531373
89regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.29531373
90post-embryonic morphogenesis (GO:0009886)3.29116040
91protein prenylation (GO:0018342)3.27647247
92prenylation (GO:0097354)3.27647247
93mitochondrion localization (GO:0051646)3.26672319
94mitochondrial RNA metabolic process (GO:0000959)3.26651059
95chromosome condensation (GO:0030261)3.25454674
96regulation of proton transport (GO:0010155)3.24309506
97notochord development (GO:0030903)3.20122057
98positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.18160752
99macroautophagy (GO:0016236)3.16396399
100very-low-density lipoprotein particle assembly (GO:0034379)3.14383051
101regulation of penile erection (GO:0060405)3.12759921
102positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.12695174
103intraciliary transport (GO:0042073)3.11511138
104synapsis (GO:0007129)3.11384444
105protein K11-linked deubiquitination (GO:0035871)3.08026114
106mitotic sister chromatid cohesion (GO:0007064)3.08008209
107DNA packaging (GO:0006323)3.05109948
108cilium organization (GO:0044782)3.04681525
109sarcoplasmic reticulum calcium ion transport (GO:0070296)3.04667605
110establishment of integrated proviral latency (GO:0075713)3.03164351
111tolerance induction (GO:0002507)3.02668366
112maternal placenta development (GO:0001893)3.01517675
113single strand break repair (GO:0000012)3.00316786
114meiotic cell cycle (GO:0051321)2.99209265
115regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.99192200
116positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.99192200
117cellular component assembly involved in morphogenesis (GO:0010927)2.98300398
118regulation of monocyte differentiation (GO:0045655)2.97818140
119cellular protein complex localization (GO:0034629)2.93687737
120cilium assembly (GO:0042384)2.92679992
121sexual reproduction (GO:0019953)2.92495626
122negative regulation of organelle assembly (GO:1902116)2.91667930
123regulation of response to osmotic stress (GO:0047484)2.91223379
124positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.89545375
125response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.89215257
126positive regulation of macrophage activation (GO:0043032)2.89140091
127tricarboxylic acid cycle (GO:0006099)2.88234184
128microtubule-based movement (GO:0007018)2.87986239
129regulation of chromosome segregation (GO:0051983)2.86513396
130RNA destabilization (GO:0050779)2.84769573
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84229161
132auditory receptor cell stereocilium organization (GO:0060088)2.83509651
133peptidyl-glutamic acid modification (GO:0018200)2.82705288
134alditol metabolic process (GO:0019400)2.82536064
135rRNA catabolic process (GO:0016075)2.81398773
136microtubule polymerization or depolymerization (GO:0031109)2.81255556
137chromosome segregation (GO:0007059)2.81082506
138response to misfolded protein (GO:0051788)2.80741764
139apoptotic DNA fragmentation (GO:0006309)2.80738939
140lactate metabolic process (GO:0006089)2.80614429
141regulation of spindle checkpoint (GO:0090231)2.78969849
142specification of organ identity (GO:0010092)2.77751348
143cellular hyperosmotic response (GO:0071474)2.77546741
144cilium morphogenesis (GO:0060271)2.73501326
145glycolytic process (GO:0006096)2.73207699
146regulation of exit from mitosis (GO:0007096)2.73177778
147actin-mediated cell contraction (GO:0070252)2.73157034
148regulation of superoxide anion generation (GO:0032928)2.72284052
149centriole assembly (GO:0098534)2.71306285
150positive regulation of mRNA catabolic process (GO:0061014)2.71154199
151ribosome biogenesis (GO:0042254)2.70481681
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70395500
153snRNA transcription (GO:0009301)2.69385598
154positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.67733299
155meiotic cell cycle process (GO:1903046)2.66219946
156establishment of mitotic spindle localization (GO:0040001)2.65859330
157centrosome duplication (GO:0051298)2.64470070
158mitotic nuclear envelope disassembly (GO:0007077)2.62594753
159transcription from mitochondrial promoter (GO:0006390)2.62220937
160phospholipid efflux (GO:0033700)2.60091721
161positive regulation of cell size (GO:0045793)2.59198635
162centriole replication (GO:0007099)2.58696554
163polyol catabolic process (GO:0046174)2.57868160
164response to histamine (GO:0034776)2.56757318
165DNA topological change (GO:0006265)2.56222353
166transcription elongation from RNA polymerase I promoter (GO:0006362)2.55945667
167mitotic G1 DNA damage checkpoint (GO:0031571)2.55254641
168regulation of centriole replication (GO:0046599)2.55058896
169nucleoside diphosphate phosphorylation (GO:0006165)2.52339748
170neuroblast proliferation (GO:0007405)2.51697800
171mechanoreceptor differentiation (GO:0042490)2.51517868
172single-organism membrane fusion (GO:0044801)2.50023507
173glycerol metabolic process (GO:0006071)2.49500045
174regulation of mRNA catabolic process (GO:0061013)2.49225543
175quaternary ammonium group transport (GO:0015697)2.48812275
176nucleus organization (GO:0006997)2.44386160
177GTP biosynthetic process (GO:0006183)2.38738743
178protein refolding (GO:0042026)2.34783825
179regulation of cytokine production involved in inflammatory response (GO:1900015)2.24001541
180regulation of inositol phosphate biosynthetic process (GO:0010919)2.23801329
181gene silencing by RNA (GO:0031047)2.23283253
182cell wall macromolecule metabolic process (GO:0044036)14.9741193
183cell wall macromolecule catabolic process (GO:0016998)14.9741193
184fusion of sperm to egg plasma membrane (GO:0007342)14.8450871
185acrosome assembly (GO:0001675)13.3612493
186* sperm motility (GO:0030317)12.3829912
187* multicellular organism reproduction (GO:0032504)12.3501284
188cilium or flagellum-dependent cell motility (GO:0001539)12.0670853
189* sperm-egg recognition (GO:0035036)11.9701988
190plasma membrane fusion (GO:0045026)11.2694518
191acrosome reaction (GO:0007340)11.0805756
192* cell-cell recognition (GO:0009988)10.7061312
193binding of sperm to zona pellucida (GO:0007339)10.4421366
194* reproduction (GO:0000003)10.1750887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.99115913
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.23958847
3FOXM1_23109430_ChIP-Seq_U2OS_Human6.20560096
4E2F7_22180533_ChIP-Seq_HELA_Human4.63601677
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35804795
6EZH2_22144423_ChIP-Seq_EOC_Human3.27403293
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09695960
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92100951
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78645396
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78179221
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60309137
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55880690
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.54825562
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.53285044
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51508243
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47587844
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42853176
18AR_21909140_ChIP-Seq_LNCAP_Human2.38980522
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.32086198
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24988186
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24341506
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15114623
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11012758
24DCP1A_22483619_ChIP-Seq_HELA_Human2.10804892
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.10065780
26VDR_22108803_ChIP-Seq_LS180_Human2.08949553
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07576987
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06641192
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97225967
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96994559
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96922216
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.95804587
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94980484
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.91915977
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91261818
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.90597413
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87736158
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.87205518
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84668746
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81529731
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80135242
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.80074005
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78775744
44ZNF263_19887448_ChIP-Seq_K562_Human1.77519732
45ZNF274_21170338_ChIP-Seq_K562_Hela1.75998298
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.71713946
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68347155
48KDM2B_26808549_Chip-Seq_REH_Human1.66282776
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64490500
50BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.63267230
51CBP_20019798_ChIP-Seq_JUKART_Human1.62810918
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62810918
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62722849
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62404613
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62345392
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.62253521
57P68_20966046_ChIP-Seq_HELA_Human1.62072950
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60575695
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60538096
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57523345
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56967107
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56534581
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56257555
64STAT1_17558387_ChIP-Seq_HELA_Human1.55576791
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.55354790
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.53013617
67KDM5A_27292631_Chip-Seq_BREAST_Human1.52205464
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50495990
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48164376
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.48161945
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47851584
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45653651
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.45518302
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.45507907
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.44801194
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44521121
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44489749
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.44294776
79XRN2_22483619_ChIP-Seq_HELA_Human1.43218427
80P300_18555785_Chip-Seq_ESCs_Mouse1.42998052
81P53_22387025_ChIP-Seq_ESCs_Mouse1.42620233
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41897601
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41497830
84GATA3_21867929_ChIP-Seq_TH1_Mouse1.40866999
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.40254410
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40069344
87KLF4_18555785_Chip-Seq_ESCs_Mouse1.39458858
88RNF2_27304074_Chip-Seq_NSC_Mouse1.38690616
89WDR5_24793694_ChIP-Seq_LNCAP_Human1.38668373
90TFEB_21752829_ChIP-Seq_HELA_Human1.38553833
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37357247
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37190116
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37086269
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.36719084
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35411873
96FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35323418
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34485204
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34216133
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33514765
100GATA1_22025678_ChIP-Seq_K562_Human1.32835104
101SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30985296
102GF1_26923725_Chip-Seq_HPCs_Mouse1.30961394
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30461900
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.30404986
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29984416
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.29910312
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29825629
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.29587124
109LXR_22292898_ChIP-Seq_THP-1_Human1.28506976
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.28356106
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27178214
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26563594
113RACK7_27058665_Chip-Seq_MCF-7_Human1.25785631
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24395238
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.23867422
116LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23226067
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23215075
118REST_21632747_ChIP-Seq_MESCs_Mouse1.21245350
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.20039138
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19467962
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19132731
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19101080
123SMC4_20622854_ChIP-Seq_HELA_Human1.18077714
124NMYC_18555785_Chip-Seq_ESCs_Mouse1.17726239
125BCOR_27268052_Chip-Seq_Bcells_Human1.17646225
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17428408
127SRF_21415370_ChIP-Seq_HL-1_Mouse1.17219398
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16832213
129MYC_22102868_ChIP-Seq_BL_Human1.15188263
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14927773
131PU1_27457419_Chip-Seq_LIVER_Mouse1.14687805
132GATA6_25053715_ChIP-Seq_YYC3_Human1.14458571
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13434355
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12575748
135ZFX_18555785_Chip-Seq_ESCs_Mouse1.12465940
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11912286
137* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11339197
138E2F1_21310950_ChIP-Seq_MCF-7_Human1.11206522
139* SPI1_26923725_Chip-Seq_HPCs_Mouse1.09143161
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08308381
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08091958
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07957702
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07883424
144ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07481770
145PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06695144
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06285498
147P53_21459846_ChIP-Seq_SAOS-2_Human1.05569613
148GABP_19822575_ChIP-Seq_HepG2_Human1.05414685
149ELK3_25401928_ChIP-Seq_HUVEC_Human1.05312252
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04656819
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04234465
152NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03792469
153* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02860846
154MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02800427
155GF1B_26923725_Chip-Seq_HPCs_Mouse1.02488833
156MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01332116
157KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00982393
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00981374
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00976272
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00976272
161E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00927334
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99881609
163E2F1_20622854_ChIP-Seq_HELA_Human0.99575038
164SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99353519
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98896968
166VDR_21846776_ChIP-Seq_THP-1_Human0.98713751
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.96881465
168FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96642432
169TET1_21490601_ChIP-Seq_MESCs_Mouse0.96084785
170KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95628588
171SA1_27219007_Chip-Seq_Bcells_Human0.94817417
172TAF15_26573619_Chip-Seq_HEK293_Human0.94448348
173OCT4_20526341_ChIP-Seq_ESCs_Human0.94379196
174RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94019824
175GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93910562
176NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93796320
177ER_23166858_ChIP-Seq_MCF-7_Human0.93252835
178CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93090582
179SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92703309
180BCL6_27268052_Chip-Seq_Bcells_Human0.91702082
181CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91609426
182HNFA_21074721_ChIP-Seq_CACO-2_Human0.90384687
183CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89614580
184ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89529132
185RARA_24833708_ChIP-Seq_LIVER_Mouse0.89262571
186LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88863341
187KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88411208
188FOXP3_21729870_ChIP-Seq_TREG_Human0.88282311
189SOX9_26525672_Chip-Seq_HEART_Mouse0.87965539
190STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87255368
191ATF3_27146783_Chip-Seq_COLON_Human0.86166931
192* PHF8_20622854_ChIP-Seq_HELA_Human0.85975705
193ELF1_20517297_ChIP-Seq_JURKAT_Human0.85880991
194SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85788649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.87317869
2* MP0001929_abnormal_gametogenesis5.22709741
3MP0008877_abnormal_DNA_methylation4.22687614
4MP0005451_abnormal_body_composition3.81956393
5MP0002837_dystrophic_cardiac_calcinosis3.56373729
6MP0002210_abnormal_sex_determination3.36381053
7* MP0002161_abnormal_fertility/fecundity3.13452401
8MP0002653_abnormal_ependyma_morphology3.00815513
9MP0001145_abnormal_male_reproductive2.87503540
10MP0009840_abnormal_foam_cell2.85373480
11MP0003806_abnormal_nucleotide_metabolis2.76780994
12MP0005670_abnormal_white_adipose2.60379051
13MP0005623_abnormal_meninges_morphology2.59024218
14MP0000653_abnormal_sex_gland2.56098068
15MP0000749_muscle_degeneration2.50924642
16MP0008260_abnormal_autophagy2.49495209
17MP0005330_cardiomyopathy2.48166356
18MP0005058_abnormal_lysosome_morphology2.47189037
19MP0003693_abnormal_embryo_hatching2.44869710
20MP0002877_abnormal_melanocyte_morpholog2.39474093
21MP0008007_abnormal_cellular_replicative2.21273272
22MP0003111_abnormal_nucleus_morphology2.18370613
23MP0009046_muscle_twitch2.10798505
24MP0003646_muscle_fatigue2.10207839
25MP0004215_abnormal_myocardial_fiber2.06900477
26MP0003828_pulmonary_edema2.03794838
27MP0001485_abnormal_pinna_reflex2.01225547
28MP0005410_abnormal_fertilization15.4929085
29MP0004185_abnormal_adipocyte_glucose1.95230306
30MP0004957_abnormal_blastocyst_morpholog1.91717322
31MP0000751_myopathy1.76031687
32MP0000747_muscle_weakness1.68074491
33MP0003077_abnormal_cell_cycle1.65906228
34MP0004233_abnormal_muscle_weight1.63622503
35MP0006138_congestive_heart_failure1.61751493
36MP0008961_abnormal_basal_metabolism1.58942815
37MP0003191_abnormal_cellular_cholesterol1.43781546
38MP0004087_abnormal_muscle_fiber1.43166637
39MP0002282_abnormal_trachea_morphology1.39914725
40MP0001765_abnormal_ion_homeostasis1.38313144
41MP0001984_abnormal_olfaction1.37240858
42MP0008058_abnormal_DNA_repair1.19544366
43MP0003172_abnormal_lysosome_physiology1.19453949
44MP0001853_heart_inflammation1.19147504
45MP0003137_abnormal_impulse_conducting1.16019434
46MP0003011_delayed_dark_adaptation1.15557506
47MP0000343_altered_response_to1.14778819
48MP0002160_abnormal_reproductive_system1.14424691
49MP0001730_embryonic_growth_arrest1.13634655
50MP0005647_abnormal_sex_gland1.11783987
51MP0002332_abnormal_exercise_endurance1.11539383
52MP0003943_abnormal_hepatobiliary_system1.02082872
53MP0002638_abnormal_pupillary_reflex1.01055900
54MP0005076_abnormal_cell_differentiation0.99997691
55MP0002972_abnormal_cardiac_muscle0.99653701
56MP0003950_abnormal_plasma_membrane0.98135541
57MP0008995_early_reproductive_senescence0.98116641
58MP0004264_abnormal_extraembryonic_tissu0.98082109
59MP0000759_abnormal_skeletal_muscle0.97159511
60MP0008775_abnormal_heart_ventricle0.96238896
61MP0010630_abnormal_cardiac_muscle0.95589640
62MP0005083_abnormal_biliary_tract0.93517566
63MP0003221_abnormal_cardiomyocyte_apopto0.91565266
64MP0008932_abnormal_embryonic_tissue0.88897822
65MP0000462_abnormal_digestive_system0.87706885
66MP0003195_calcinosis0.87048690
67MP0005375_adipose_tissue_phenotype0.86645779
68MP0003329_amyloid_beta_deposits0.86518366
69MP0002971_abnormal_brown_adipose0.85042851
70MP0001727_abnormal_embryo_implantation0.84648191
71MP0002080_prenatal_lethality0.83595623
72MP0002106_abnormal_muscle_physiology0.83219229
73MP0009333_abnormal_splenocyte_physiolog0.83034577
74MP0002970_abnormal_white_adipose0.81761241
75MP0000569_abnormal_digit_pigmentation0.81545186
76MP0003656_abnormal_erythrocyte_physiolo0.79880161
77MP0005408_hypopigmentation0.77297727
78MP0004510_myositis0.77117760
79MP0002092_abnormal_eye_morphology0.76836794
80MP0005636_abnormal_mineral_homeostasis0.76713863
81MP0005551_abnormal_eye_electrophysiolog0.75037579
82MP0004019_abnormal_vitamin_homeostasis0.73733549
83MP0005671_abnormal_response_to0.72542414
84MP0004036_abnormal_muscle_relaxation0.71434854
85MP0008004_abnormal_stomach_pH0.70559754
86MP0001849_ear_inflammation0.67945633
87MP0005380_embryogenesis_phenotype0.67936349
88MP0001672_abnormal_embryogenesis/_devel0.67936349
89MP0005666_abnormal_adipose_tissue0.67892866
90MP0005360_urolithiasis0.66939203
91MP0006036_abnormal_mitochondrial_physio0.66620018
92MP0005253_abnormal_eye_physiology0.66466127
93MP0005385_cardiovascular_system_phenoty0.65908354
94MP0001544_abnormal_cardiovascular_syste0.65908354
95MP0010307_abnormal_tumor_latency0.65398048
96MP0000313_abnormal_cell_death0.65017272
97MP0005620_abnormal_muscle_contractility0.64783895
98MP0000609_abnormal_liver_physiology0.64118747
99MP0002102_abnormal_ear_morphology0.64027149
100MP0005266_abnormal_metabolism0.62472884
101MP0001661_extended_life_span0.62330925
102MP0001697_abnormal_embryo_size0.61292051
103MP0004742_abnormal_vestibular_system0.60764376
104MP0005389_reproductive_system_phenotype0.59995356
105MP0003699_abnormal_female_reproductive0.58873246
106MP0003984_embryonic_growth_retardation0.58851409
107MP0006035_abnormal_mitochondrial_morpho0.57767504
108MP0003633_abnormal_nervous_system0.55985211
109MP0001905_abnormal_dopamine_level0.52315440
110MP0000358_abnormal_cell_content/0.51352464
111MP0000604_amyloidosis0.50513728
112MP0003631_nervous_system_phenotype0.48831175
113MP0001764_abnormal_homeostasis0.47199048
114MP0001324_abnormal_eye_pigmentation0.46732154
115MP0005365_abnormal_bile_salt0.46359026
116MP0001119_abnormal_female_reproductive0.46248642
117MP0002139_abnormal_hepatobiliary_system0.44686121
118MP0002928_abnormal_bile_duct0.43989516
119MP0002269_muscular_atrophy0.43246608
120MP0010094_abnormal_chromosome_stability0.40792722
121MP0005391_vision/eye_phenotype0.40377143
122MP0000427_abnormal_hair_cycle0.39269954
123MP0009115_abnormal_fat_cell0.39177767
124MP0002229_neurodegeneration0.37218386
125MP0003136_yellow_coat_color0.36802574
126MP0004145_abnormal_muscle_electrophysio0.35630760
127MP0003718_maternal_effect0.35050733
128MP0002132_abnormal_respiratory_system0.33460198
129MP0001968_abnormal_touch/_nociception0.33236033
130MP0004084_abnormal_cardiac_muscle0.32811862
131MP0008875_abnormal_xenobiotic_pharmacok0.31781499
132MP0002796_impaired_skin_barrier0.31352902
133MP0003879_abnormal_hair_cell0.30211014
134MP0001293_anophthalmia0.29437275
135MP0005195_abnormal_posterior_eye0.29169968
136MP0009250_abnormal_appendicular_skeleto0.28751302
137MP0005535_abnormal_body_temperature0.28209669
138MP0003634_abnormal_glial_cell0.28111232
139MP0004381_abnormal_hair_follicle0.28101143
140MP0002234_abnormal_pharynx_morphology0.27151442
141MP0003959_abnormal_lean_body0.26964813
142MP0002118_abnormal_lipid_homeostasis0.26491875
143MP0005319_abnormal_enzyme/_coenzyme0.26236899
144MP0003632_abnormal_nervous_system0.25796271
145MP0002572_abnormal_emotion/affect_behav0.25501949
146MP0000579_abnormal_nail_morphology0.25448608
147MP0005377_hearing/vestibular/ear_phenot0.24363457
148MP0003878_abnormal_ear_physiology0.24363457
149MP0003786_premature_aging0.24263679
150MP0001986_abnormal_taste_sensitivity0.23483481
151MP0002736_abnormal_nociception_after0.23356921
152MP0004130_abnormal_muscle_cell0.23083522
153MP0008569_lethality_at_weaning0.22619072
154MP0009745_abnormal_behavioral_response0.21975175
155MP0000920_abnormal_myelination0.21677743
156MP0004811_abnormal_neuron_physiology0.21529552
157MP0002752_abnormal_somatic_nervous0.21401822
158MP0009697_abnormal_copulation0.20598735
159MP0002557_abnormal_social/conspecific_i0.20435246
160MP0000026_abnormal_inner_ear0.19470194
161MP0002152_abnormal_brain_morphology0.19377356
162MP0002295_abnormal_pulmonary_circulatio0.19362953
163MP0006072_abnormal_retinal_apoptosis0.19322314
164MP0003635_abnormal_synaptic_transmissio0.18236416
165MP0001486_abnormal_startle_reflex0.17285428
166MP0005395_other_phenotype0.17198091

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.49458466
2Abnormal respiratory epithelium morphology (HP:0012253)8.48848393
3Abnormal respiratory motile cilium morphology (HP:0005938)8.48848393
4Abnormal ciliary motility (HP:0012262)8.01740373
5Rhinitis (HP:0012384)7.89695852
6Chronic bronchitis (HP:0004469)6.79604621
7Nasal polyposis (HP:0100582)6.36189836
8Infertility (HP:0000789)5.88408802
9Abnormality of the nasal mucosa (HP:0000433)5.17178711
10Bronchiectasis (HP:0002110)4.65840974
11Bronchitis (HP:0012387)4.55878746
12Exercise-induced myalgia (HP:0003738)4.31321340
13Nephronophthisis (HP:0000090)4.30341000
14Right ventricular cardiomyopathy (HP:0011663)4.22885304
15Male infertility (HP:0003251)4.14795286
16Potter facies (HP:0002009)3.88716698
17Facial shape deformation (HP:0011334)3.88716698
18Abnormal spermatogenesis (HP:0008669)3.77102408
19Recurrent sinusitis (HP:0011108)3.65366747
20Retinal atrophy (HP:0001105)3.64794300
21Bilateral sensorineural hearing impairment (HP:0008619)3.58061731
2211 pairs of ribs (HP:0000878)3.41394319
23Recurrent otitis media (HP:0000403)3.41193644
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24196362
25Abnormality of polysaccharide metabolism (HP:0011012)3.24196362
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24196362
27Abnormality of the renal medulla (HP:0100957)3.22089656
28Redundant skin (HP:0001582)3.21456492
29Medial flaring of the eyebrow (HP:0010747)3.21073317
30Progressive muscle weakness (HP:0003323)3.15005981
31Recurrent bronchitis (HP:0002837)3.06728163
32Ventricular tachycardia (HP:0004756)3.06200539
33Ragged-red muscle fibers (HP:0003200)3.01034277
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99843999
35Sudden death (HP:0001699)2.99058816
36EMG: myopathic abnormalities (HP:0003458)2.95466989
37Tubulointerstitial nephritis (HP:0001970)2.91256663
38Chromsome breakage (HP:0040012)2.87205992
39Increased connective tissue (HP:0009025)2.86350991
40Mucopolysacchariduria (HP:0008155)2.77803896
41Urinary glycosaminoglycan excretion (HP:0003541)2.77803896
42Dysostosis multiplex (HP:0000943)2.76566948
43Fetal akinesia sequence (HP:0001989)2.75132968
44Azoospermia (HP:0000027)2.74107014
45Gastrointestinal stroma tumor (HP:0100723)2.67724413
46Molar tooth sign on MRI (HP:0002419)2.67587374
47Abnormality of midbrain morphology (HP:0002418)2.67587374
48Hypokalemic alkalosis (HP:0001949)2.63689041
49Birth length less than 3rd percentile (HP:0003561)2.59454924
50Gonadotropin excess (HP:0000837)2.58289742
51Tubulointerstitial abnormality (HP:0001969)2.58267974
52Muscle fiber inclusion bodies (HP:0100299)2.57286490
53Tubular atrophy (HP:0000092)2.57214815
54Difficulty climbing stairs (HP:0003551)2.54649940
55Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.52256901
56Increased circulating renin level (HP:0000848)2.51670115
57Thoracic kyphosis (HP:0002942)2.46659870
58Impaired proprioception (HP:0010831)2.46543171
59Abnormality of chloride homeostasis (HP:0011422)2.43821713
60Multiple enchondromatosis (HP:0005701)2.43777041
61Axonal loss (HP:0003447)2.41028727
62Duplicated collecting system (HP:0000081)2.40557935
63Myoglobinuria (HP:0002913)2.39762058
64Metaphyseal cupping (HP:0003021)2.38556800
65Impulsivity (HP:0100710)2.37953013
66Nemaline bodies (HP:0003798)2.36158225
67Tongue fasciculations (HP:0001308)2.34984613
68Increased serum pyruvate (HP:0003542)2.34864294
69Progressive hearing impairment (HP:0001730)2.27137325
70Rhabdomyolysis (HP:0003201)2.25803046
71Trismus (HP:0000211)2.22898020
72Progressive external ophthalmoplegia (HP:0000590)2.22702785
73Poor eye contact (HP:0000817)2.19692020
74Hyperactive renin-angiotensin system (HP:0000841)2.17060540
75Severe muscular hypotonia (HP:0006829)2.14547598
76Tubulointerstitial fibrosis (HP:0005576)2.13360275
77Muscle fibrillation (HP:0010546)2.11392849
78Chronic sinusitis (HP:0011109)2.11334015
79Decreased central vision (HP:0007663)2.10648545
80Abnormality of the periventricular white matter (HP:0002518)2.10279185
81Abnormality of glycolysis (HP:0004366)2.09629798
82Abnormality of saccadic eye movements (HP:0000570)2.08976119
83Exercise-induced muscle cramps (HP:0003710)2.08930307
84Postaxial foot polydactyly (HP:0001830)2.08723380
85Optic nerve hypoplasia (HP:0000609)2.07930536
86Vertebral hypoplasia (HP:0008417)2.07018748
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07018748
88Hyponatremia (HP:0002902)2.06992944
89Breast hypoplasia (HP:0003187)2.06307195
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04229502
91Diaphragmatic weakness (HP:0009113)2.04207083
92Gait imbalance (HP:0002141)2.02926608
93Congenital primary aphakia (HP:0007707)2.01749297
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0363046
95Dynein arm defect of respiratory motile cilia (HP:0012255)12.3588992
96Absent/shortened dynein arms (HP:0200106)12.3588992
97Congenital hepatic fibrosis (HP:0002612)1.98204533
98Abnormality of pyrimidine metabolism (HP:0004353)1.97813283
99Round ear (HP:0100830)1.97735781
100Cerebellar dysplasia (HP:0007033)1.97693280
101J-shaped sella turcica (HP:0002680)1.95766722
102Nuclear cataract (HP:0100018)1.95079963
103Stage 5 chronic kidney disease (HP:0003774)1.94749166
104Pancreatic fibrosis (HP:0100732)1.92353657
105Volvulus (HP:0002580)1.92023275
106Abnormality of fatty-acid metabolism (HP:0004359)1.91979380
107Missing ribs (HP:0000921)1.91080098
108Morphological abnormality of the inner ear (HP:0011390)1.90047453
109Microglossia (HP:0000171)1.88766645
110Abnormality of dental color (HP:0011073)1.88045391
111Metabolic alkalosis (HP:0200114)1.87969565
112Breech presentation (HP:0001623)1.87255039
113B lymphocytopenia (HP:0010976)1.86537641
114Polydipsia (HP:0001959)1.84797105
115Abnormal drinking behavior (HP:0030082)1.84797105
116Abnormality of the renal cortex (HP:0011035)1.84176211
117Xanthomatosis (HP:0000991)1.83964697
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.83874569
119Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80405800
120Generalized aminoaciduria (HP:0002909)1.79802274
121Paralysis (HP:0003470)1.79189798
122Occipital encephalocele (HP:0002085)1.79096561
123Ulnar deviation of the wrist (HP:0003049)1.78332742
124Increased cerebral lipofuscin (HP:0011813)1.77933780
125Renal salt wasting (HP:0000127)1.77703517
126Confusion (HP:0001289)1.77581404
127Personality changes (HP:0000751)1.75536087
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74958536
129Increased nuchal translucency (HP:0010880)1.74681652
130Dilated cardiomyopathy (HP:0001644)1.74329857
131Lipoatrophy (HP:0100578)1.73501308
132Proximal placement of thumb (HP:0009623)1.73413673
133Abnormal vertebral ossification (HP:0100569)1.73285235
134Increased density of long bones (HP:0006392)1.72752083
135Genital tract atresia (HP:0001827)1.71648794
136Progressive microcephaly (HP:0000253)1.71299032
137Abnormality of B cell number (HP:0010975)1.70230757
138Abnormality of the renal collecting system (HP:0004742)1.70160099
139Facial cleft (HP:0002006)1.70044613
140Renal dysplasia (HP:0000110)1.69145133
141Abnormal enzyme/coenzyme activity (HP:0012379)1.68933095
142Limb-girdle muscle atrophy (HP:0003797)1.68914638
143Abnormal tarsal ossification (HP:0008369)1.68617252
144Abnormality of the dental root (HP:0006486)1.67237296
145Taurodontia (HP:0000679)1.67237296
146Abnormality of permanent molar morphology (HP:0011071)1.67237296
147Nephrogenic diabetes insipidus (HP:0009806)1.66521364
148Aplasia/Hypoplasia of the lens (HP:0008063)1.66170904
149Spastic tetraparesis (HP:0001285)1.66022196
150Median cleft lip (HP:0000161)1.63332323
151Postaxial hand polydactyly (HP:0001162)1.62780657
152Vaginal atresia (HP:0000148)1.61733821
153Chronic hepatic failure (HP:0100626)1.60510324
154Abnormality of molar (HP:0011077)1.60107558
155Abnormality of molar morphology (HP:0011070)1.60107558
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.60036096
157Absent frontal sinuses (HP:0002688)1.59850819
158Neurofibrillary tangles (HP:0002185)1.59641629
159Fibular hypoplasia (HP:0003038)1.57361928
160Cholecystitis (HP:0001082)1.57059812
161Abnormal gallbladder physiology (HP:0012438)1.57059812
162Slow saccadic eye movements (HP:0000514)1.54820586
163Short ribs (HP:0000773)1.54346968
164Abnormality of renal excretion (HP:0011036)1.53513099
165Abnormality of ocular smooth pursuit (HP:0000617)1.52233391
166Abnormality of the dental pulp (HP:0006479)1.51340580
167Poor coordination (HP:0002370)1.49394326
168Limb ataxia (HP:0002070)1.47017924
169Impaired smooth pursuit (HP:0007772)1.44783506
170Cystic liver disease (HP:0006706)1.42043136
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.41954045
172Deformed sella turcica (HP:0002681)1.41693290
173Heterotopia (HP:0002282)1.40378724
174Oculomotor apraxia (HP:0000657)1.37789812
175Bile duct proliferation (HP:0001408)1.36376616
176Abnormal biliary tract physiology (HP:0012439)1.36376616
177Abnormality of dentin (HP:0010299)1.36233951
178Nephropathy (HP:0000112)1.31508040
179Dyschromatopsia (HP:0007641)1.30069254
180Attenuation of retinal blood vessels (HP:0007843)1.29631352
181Spontaneous abortion (HP:0005268)1.26906875
182Pachygyria (HP:0001302)1.24834584
183Bell-shaped thorax (HP:0001591)1.21737603
184Abnormal urine output (HP:0012590)1.21418171
185Asymmetric septal hypertrophy (HP:0001670)1.21009915
186Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.20489470
187True hermaphroditism (HP:0010459)1.19068373
188Abnormality of the lower motor neuron (HP:0002366)1.18512088
189Easy fatigability (HP:0003388)1.18370835
190Cerebral inclusion bodies (HP:0100314)1.18309925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.70285442
2PDK38.70285442
3PDK25.58211912
4PRPF4B5.51390286
5PRKD34.60042943
6TESK14.54291245
7TAOK24.13340130
8TSSK64.07413272
9ICK3.65034022
10NEK13.53184392
11PBK3.08162012
12STK392.75642721
13IRAK32.71467971
14WNK42.63506813
15PTK2B2.51925996
16BUB12.35921355
17BMPR21.87162209
18MST41.76998372
19LATS21.47422516
20NME11.44530964
21NME21.42599276
22STK381.41194060
23PNCK1.32815149
24PHKG21.29747801
25PHKG11.29747801
26LMTK21.29408370
27CDC42BPA1.26227859
28STK161.22243648
29RPS6KB21.19972069
30MUSK1.15273060
31TRIB31.08963351
32TAOK11.03439348
33DYRK1B1.02981896
34IRAK11.02448916
35PDK11.00038361
36TRPM70.99528057
37NEK20.97215535
38GRK60.97077948
39SRPK10.96113495
40NEK90.95310311
41CDK190.93783122
42TLK10.91023271
43MAP3K140.89644419
44WNK10.88876211
45MAPK110.81835264
46STK38L0.81280368
47MAP2K30.80706015
48MAP2K60.79052790
49ABL20.78906972
50ACVR1B0.77597841
51ZAK0.76767259
52IRAK20.76339247
53MAP2K70.76057074
54TTN0.74216828
55EPHA20.71361519
56STK40.69959325
57CHEK20.69562086
58TYRO30.69514637
59OBSCN0.69450440
60NTRK20.68118251
61LATS10.67027166
62SIK10.66895458
63MAPK150.66375284
64TBK10.65849626
65MST1R0.64745261
66MAP3K80.63866732
67TXK0.63747694
68EIF2AK20.61944265
69ERBB30.60540209
70PIK3CG0.58313785
71TTK0.58244257
72BRSK20.57248147
73CASK0.53197330
74WEE10.52176340
75STK30.52114457
76AURKB0.51810325
77CDK40.50855033
78EIF2AK10.46716625
79PDPK10.46104752
80MAP3K30.45928308
81PLK40.45145661
82CAMK1D0.45064644
83MAPK120.44640910
84MKNK20.44266661
85MELK0.41227829
86CDK70.41045714
87AKT20.39514975
88PRKCI0.39309983
89BMPR1B0.39191535
90PRKCG0.38276069
91CHEK10.38072342
92DYRK30.37407732
93PLK30.37148861
94ALK0.36875837
95SMG10.36412570
96MAPKAPK20.36216016
97PINK10.35009906
98CDK120.34892449
99ZAP700.34752745
100CCNB10.33287218
101CLK10.33228994
102MARK30.33021697
103MAP3K40.33005413
104IKBKB0.32920239
105NEK60.32911204
106PAK10.32907094
107TIE10.28799583
108EEF2K0.27432004
109PRKAA10.26780985
110ROCK10.26128518
111RPS6KA10.26073882
112BRAF0.25594466
113RPS6KA20.25557541
114CAMK1G0.25485197
115STK100.25365532
116ADRBK20.24399283
117STK240.23945783
118MAP2K40.23144398
119KSR20.23040913
120OXSR10.22688101
121MARK20.21906362
122PASK0.21318278
123PRKCQ0.20979573
124PKN10.20838459
125RIPK40.20271132
126ATM0.19517804
127PRKG20.19003752
128MAPKAPK50.18062674
129MAPKAPK30.17362793
130MET0.12127335
131RPS6KB10.11921526
132PLK10.11607593
133STK110.11533756
134BRSK10.09958623
135CDK50.09558043
136EPHB10.09553362
137GRK10.09339986
138CAMK2A0.09098517
139ATR0.07580275
140PRKACG0.07576704
141PRKCZ0.06468961
142CSNK2A20.06216016
143PRKG10.05848291
144CDK150.05460257
145CSNK2A10.04743211
146TNIK0.04644982
147GSK3B0.04088789
148PRKACA0.04069255
149CSNK1D0.03825496
150PRKCA0.03810882
151EGFR0.03496435
152MAP3K50.03273466
153PRKAA20.03181537
154PRKCB0.03177919
155TESK20.03015832
156CDK180.02165278
157PRKCD0.01601463
158MTOR0.01238664
159AURKA0.00951509
160PRKACB0.00744746
161CDK10.00517741
162PAK20.00441529
163YES10.00024276
164MAP3K1-0.0012379

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.09244252
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.85723199
3Propanoate metabolism_Homo sapiens_hsa006403.54439620
4Pyruvate metabolism_Homo sapiens_hsa006203.52877763
5Fatty acid biosynthesis_Homo sapiens_hsa000613.43060459
6Pentose phosphate pathway_Homo sapiens_hsa000302.86985272
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76059275
8Non-homologous end-joining_Homo sapiens_hsa034502.68345031
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.65211280
10Linoleic acid metabolism_Homo sapiens_hsa005912.55894693
11Basal transcription factors_Homo sapiens_hsa030222.46932219
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.43802543
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36952647
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36116668
15Other glycan degradation_Homo sapiens_hsa005112.33441910
16Glucagon signaling pathway_Homo sapiens_hsa049222.22163355
17PPAR signaling pathway_Homo sapiens_hsa033202.14961337
18One carbon pool by folate_Homo sapiens_hsa006702.13089418
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07088936
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04309153
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00964984
22Fanconi anemia pathway_Homo sapiens_hsa034602.00860287
23Renin-angiotensin system_Homo sapiens_hsa046141.94440346
24Carbon metabolism_Homo sapiens_hsa012001.84952475
25Sulfur metabolism_Homo sapiens_hsa009201.84267464
26DNA replication_Homo sapiens_hsa030301.77843822
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75310839
28Nucleotide excision repair_Homo sapiens_hsa034201.71545448
29Huntingtons disease_Homo sapiens_hsa050161.71461828
30Glycerolipid metabolism_Homo sapiens_hsa005611.69068561
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66043105
32Spliceosome_Homo sapiens_hsa030401.65204100
33Base excision repair_Homo sapiens_hsa034101.65061514
34Selenocompound metabolism_Homo sapiens_hsa004501.60915695
35Fatty acid degradation_Homo sapiens_hsa000711.58300121
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.57274487
37Cell cycle_Homo sapiens_hsa041101.53474638
38Ether lipid metabolism_Homo sapiens_hsa005651.52573082
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52264370
40Fatty acid metabolism_Homo sapiens_hsa012121.51862067
41Cardiac muscle contraction_Homo sapiens_hsa042601.47516224
42Oocyte meiosis_Homo sapiens_hsa041141.47034616
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43186710
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41131716
45Mineral absorption_Homo sapiens_hsa049781.38322568
46Lysosome_Homo sapiens_hsa041421.34408536
47Biosynthesis of amino acids_Homo sapiens_hsa012301.33271682
48Fructose and mannose metabolism_Homo sapiens_hsa000511.27515148
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25464038
50Prion diseases_Homo sapiens_hsa050201.22422698
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18982082
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.16611427
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15702401
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15246636
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.13797570
56Dilated cardiomyopathy_Homo sapiens_hsa054141.11282467
57Dorso-ventral axis formation_Homo sapiens_hsa043201.08730927
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05850338
59Mismatch repair_Homo sapiens_hsa034301.03824539
60RNA degradation_Homo sapiens_hsa030181.01861872
61Pyrimidine metabolism_Homo sapiens_hsa002401.01601654
62Fat digestion and absorption_Homo sapiens_hsa049751.01545562
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99342266
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98331147
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96636831
66Tryptophan metabolism_Homo sapiens_hsa003800.92851284
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92315364
68Butanoate metabolism_Homo sapiens_hsa006500.91232956
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89743676
70Antigen processing and presentation_Homo sapiens_hsa046120.87439525
71Arachidonic acid metabolism_Homo sapiens_hsa005900.86639156
72Legionellosis_Homo sapiens_hsa051340.85360432
73mRNA surveillance pathway_Homo sapiens_hsa030150.84142676
74Chemical carcinogenesis_Homo sapiens_hsa052040.83329997
75Sulfur relay system_Homo sapiens_hsa041220.83273932
76Renin secretion_Homo sapiens_hsa049240.82780775
77Purine metabolism_Homo sapiens_hsa002300.80557976
78ABC transporters_Homo sapiens_hsa020100.78406012
79Amphetamine addiction_Homo sapiens_hsa050310.77214032
80Bile secretion_Homo sapiens_hsa049760.75649482
81Glutathione metabolism_Homo sapiens_hsa004800.74509820
82Arginine and proline metabolism_Homo sapiens_hsa003300.73717171
83p53 signaling pathway_Homo sapiens_hsa041150.69056009
84Galactose metabolism_Homo sapiens_hsa000520.65872241
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63442088
86Metabolic pathways_Homo sapiens_hsa011000.63182330
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63085665
88Insulin secretion_Homo sapiens_hsa049110.59778750
89Herpes simplex infection_Homo sapiens_hsa051680.58782764
90Lysine degradation_Homo sapiens_hsa003100.57715612
91Taste transduction_Homo sapiens_hsa047420.56211469
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.55688765
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55226477
94Notch signaling pathway_Homo sapiens_hsa043300.53437836
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52410127
96Arginine biosynthesis_Homo sapiens_hsa002200.51726820
97Complement and coagulation cascades_Homo sapiens_hsa046100.51094243
98Peroxisome_Homo sapiens_hsa041460.50290505
99Calcium signaling pathway_Homo sapiens_hsa040200.48063074
100Thyroid hormone synthesis_Homo sapiens_hsa049180.47750858
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46826652
102Starch and sucrose metabolism_Homo sapiens_hsa005000.46678944
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.46152472
104RNA transport_Homo sapiens_hsa030130.45103386
105Tyrosine metabolism_Homo sapiens_hsa003500.44953174
106Fatty acid elongation_Homo sapiens_hsa000620.44918097
107AMPK signaling pathway_Homo sapiens_hsa041520.44915434
108Caffeine metabolism_Homo sapiens_hsa002320.44637513
109Tight junction_Homo sapiens_hsa045300.44634943
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42257764
111Collecting duct acid secretion_Homo sapiens_hsa049660.41978503
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41664741
113Protein digestion and absorption_Homo sapiens_hsa049740.40298670
114beta-Alanine metabolism_Homo sapiens_hsa004100.40097249
115Inositol phosphate metabolism_Homo sapiens_hsa005620.39780120
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38452535
117Proteasome_Homo sapiens_hsa030500.36299565
118Endocytosis_Homo sapiens_hsa041440.35168309
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35079287
120Retinol metabolism_Homo sapiens_hsa008300.34983048
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.34132369
122Systemic lupus erythematosus_Homo sapiens_hsa053220.33287640
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33216906
124Epstein-Barr virus infection_Homo sapiens_hsa051690.32700354
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32396256
126Homologous recombination_Homo sapiens_hsa034400.31310735
127Synaptic vesicle cycle_Homo sapiens_hsa047210.30418866
128Pancreatic secretion_Homo sapiens_hsa049720.30090051
129cAMP signaling pathway_Homo sapiens_hsa040240.29117728
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27713484
131N-Glycan biosynthesis_Homo sapiens_hsa005100.27457641
132MAPK signaling pathway_Homo sapiens_hsa040100.27048244
133Insulin signaling pathway_Homo sapiens_hsa049100.26690179
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.26683170
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26477024
136HTLV-I infection_Homo sapiens_hsa051660.26083896
137Estrogen signaling pathway_Homo sapiens_hsa049150.25934205
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25788118
139Folate biosynthesis_Homo sapiens_hsa007900.25760213
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25506835
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.25045315
142Sphingolipid metabolism_Homo sapiens_hsa006000.24602120
143Ovarian steroidogenesis_Homo sapiens_hsa049130.24572235
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23129555
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22591753
146Histidine metabolism_Homo sapiens_hsa003400.22426381
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.22170584
148Salivary secretion_Homo sapiens_hsa049700.22039121
149Small cell lung cancer_Homo sapiens_hsa052220.21523742
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19198892
151Gastric acid secretion_Homo sapiens_hsa049710.16762282
152Phenylalanine metabolism_Homo sapiens_hsa003600.16568727
153Oxidative phosphorylation_Homo sapiens_hsa001900.15530885

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