CATSPER4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* multicellular organism reproduction (GO:0032504)9.91080436
2acrosome assembly (GO:0001675)9.78544061
3axonemal dynein complex assembly (GO:0070286)9.77634102
4epithelial cilium movement (GO:0003351)9.39812614
5* sperm-egg recognition (GO:0035036)9.36212773
6cilium or flagellum-dependent cell motility (GO:0001539)9.31423521
7motile cilium assembly (GO:0044458)8.99610784
8plasma membrane fusion (GO:0045026)8.70093800
9regulation of gonadotropin secretion (GO:0032276)8.40934209
10* cell-cell recognition (GO:0009988)8.34053487
11binding of sperm to zona pellucida (GO:0007339)8.25365422
12rhodopsin mediated signaling pathway (GO:0016056)8.16189749
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.11770185
14* reproduction (GO:0000003)7.92853153
15spermatid development (GO:0007286)7.87701953
16cilium movement (GO:0003341)7.78251518
17tachykinin receptor signaling pathway (GO:0007217)7.75249765
18histone H3-K36 demethylation (GO:0070544)7.71705114
19regulation of cilium movement (GO:0003352)7.58192962
20* single fertilization (GO:0007338)6.75762192
21piRNA metabolic process (GO:0034587)6.47650879
22positive regulation of uterine smooth muscle contraction (GO:0070474)6.20156382
23regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.10938143
24microtubule depolymerization (GO:0007019)6.05702076
25male meiosis (GO:0007140)5.89673088
26spermatogenesis (GO:0007283)5.55149479
27male gamete generation (GO:0048232)5.53491717
28* fertilization (GO:0009566)5.53313171
29organic cation transport (GO:0015695)5.53138149
30* sperm capacitation (GO:0048240)5.52491351
31positive regulation of vascular permeability (GO:0043117)5.42817223
32gamete generation (GO:0007276)5.12791810
33synaptonemal complex organization (GO:0070193)5.10337454
34outflow tract septum morphogenesis (GO:0003148)4.95960262
35synaptonemal complex assembly (GO:0007130)4.88102423
36regulation of uterine smooth muscle contraction (GO:0070472)4.83007169
37positive regulation of neurotransmitter secretion (GO:0001956)4.77297461
38negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.72396654
39negative regulation of inclusion body assembly (GO:0090084)4.60028180
40calcium ion-dependent exocytosis (GO:0017156)4.56566246
41melanin biosynthetic process (GO:0042438)4.51474631
42regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.46357406
43ventricular system development (GO:0021591)4.45852958
44tooth mineralization (GO:0034505)4.44259611
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.40860065
46* cellular process involved in reproduction in multicellular organism (GO:0022412)4.38824767
47secondary metabolite biosynthetic process (GO:0044550)4.38333490
48phasic smooth muscle contraction (GO:0014821)4.38229716
49germ cell development (GO:0007281)4.37639100
50tongue development (GO:0043586)4.36629907
51regulation of microtubule-based movement (GO:0060632)4.11132380
52male meiosis I (GO:0007141)4.10088012
53interferon-gamma secretion (GO:0072643)4.07582768
54negative regulation of metanephros development (GO:0072217)4.06047840
55DNA methylation involved in gamete generation (GO:0043046)4.04043941
56* cell recognition (GO:0008037)4.03400134
57glycerol ether metabolic process (GO:0006662)4.02848127
58seminiferous tubule development (GO:0072520)4.02570631
59rRNA methylation (GO:0031167)4.01744674
60multicellular organismal reproductive process (GO:0048609)4.00233706
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.98893252
62regulation of female gonad development (GO:2000194)3.95582725
63regulation of rhodopsin mediated signaling pathway (GO:0022400)3.95039040
64melanin metabolic process (GO:0006582)3.91283592
65positive regulation of male gonad development (GO:2000020)3.89583938
66beta-amyloid metabolic process (GO:0050435)3.86990079
67chromosome organization involved in meiosis (GO:0070192)3.84161416
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.82723971
69gonadal mesoderm development (GO:0007506)3.80675924
70centriole assembly (GO:0098534)3.77602664
71ether metabolic process (GO:0018904)3.75379339
72spermatid nucleus differentiation (GO:0007289)3.72359190
73DNA double-strand break processing (GO:0000729)3.71473808
74left/right pattern formation (GO:0060972)3.69510297
75regulation of megakaryocyte differentiation (GO:0045652)3.64246166
76phosphatidylethanolamine metabolic process (GO:0046337)3.54985730
77regulation of inclusion body assembly (GO:0090083)3.53637606
78synapsis (GO:0007129)3.50143500
79microtubule severing (GO:0051013)3.48923831
80single strand break repair (GO:0000012)3.47988076
81C4-dicarboxylate transport (GO:0015740)3.43233414
82rRNA modification (GO:0000154)3.40693102
83meiotic nuclear division (GO:0007126)3.40012352
84protein K11-linked deubiquitination (GO:0035871)3.38008892
85positive regulation of interleukin-4 production (GO:0032753)3.37068260
86* multicellular organismal development (GO:0007275)3.36231394
87negative regulation of telomere maintenance (GO:0032205)3.33245691
88negative regulation of skeletal muscle tissue development (GO:0048642)3.28805147
89positive regulation of neurotransmitter transport (GO:0051590)3.25300556
90phosphatidylglycerol biosynthetic process (GO:0006655)3.21924880
91cranial suture morphogenesis (GO:0060363)3.19560602
92cellular response to light stimulus (GO:0071482)3.16407795
93negative regulation of heart rate (GO:0010459)3.15679755
94cilium organization (GO:0044782)3.11862705
95retinoic acid receptor signaling pathway (GO:0048384)3.10743498
96regulation of actin nucleation (GO:0051125)3.08558999
97cilium assembly (GO:0042384)3.08175070
98peptidyl-arginine omega-N-methylation (GO:0035247)3.06879013
99DNA packaging (GO:0006323)3.04713705
100bone trabecula formation (GO:0060346)3.02545035
101negative regulation of cAMP-mediated signaling (GO:0043951)3.02186962
102phototransduction (GO:0007602)3.01683577
103regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.00215181
104response to interferon-beta (GO:0035456)2.98994637
105meiotic cell cycle (GO:0051321)2.97999362
106chromosome condensation (GO:0030261)2.96518073
107meiosis I (GO:0007127)2.92315366
108microtubule polymerization or depolymerization (GO:0031109)2.91640280
109detection of light stimulus (GO:0009583)2.89716572
110regulation of male gonad development (GO:2000018)2.86531348
111protein polyglutamylation (GO:0018095)2.84874253
112positive regulation of membrane potential (GO:0045838)2.83867163
113regulation of ruffle assembly (GO:1900027)2.82050887
114neuronal ion channel clustering (GO:0045161)2.79601713
115regulation of hair follicle development (GO:0051797)2.78275878
116intraciliary transport (GO:0042073)2.77801694
117negative regulation of kidney development (GO:0090185)2.77686512
118regulation of stem cell maintenance (GO:2000036)2.77292236
119cellular response to interferon-beta (GO:0035458)2.76333936
120protein localization to cilium (GO:0061512)2.76107782
121regulation of transcription involved in cell fate commitment (GO:0060850)2.75991909
122negative regulation of epidermal cell differentiation (GO:0045605)2.75839127
123cellular ketone body metabolic process (GO:0046950)2.75509152
124cellular component assembly involved in morphogenesis (GO:0010927)2.73702885
125peptidyl-arginine N-methylation (GO:0035246)2.73052818
126peptidyl-arginine methylation (GO:0018216)2.73052818
127detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.73002033
128GTP biosynthetic process (GO:0006183)2.71588474
129embryonic camera-type eye development (GO:0031076)2.71108009
130G-protein coupled receptor internalization (GO:0002031)2.69287276
131female gonad development (GO:0008585)2.68833230
132adenosine metabolic process (GO:0046085)2.67538577
133positive regulation of monocyte chemotaxis (GO:0090026)2.66891858
134positive regulation of interleukin-17 production (GO:0032740)2.66288237
135centriole replication (GO:0007099)2.65679639
136detection of temperature stimulus (GO:0016048)2.63690780
137polyol transport (GO:0015791)2.63535911
138polyol catabolic process (GO:0046174)2.62801643
139GMP metabolic process (GO:0046037)2.61879321
140mesenchymal to epithelial transition (GO:0060231)2.61333404
141membrane protein ectodomain proteolysis (GO:0006509)2.61046861
142negative regulation of viral transcription (GO:0032897)2.60085377
143sequestering of actin monomers (GO:0042989)2.59492998
144cilium morphogenesis (GO:0060271)2.59218306
145positive regulation of amine transport (GO:0051954)2.59067980
146axoneme assembly (GO:0035082)2.58510498
147positive regulation of catenin import into nucleus (GO:0035413)2.58112078
148negative regulation of T cell apoptotic process (GO:0070233)2.57535838
149cardiolipin metabolic process (GO:0032048)2.57167195
150histone arginine methylation (GO:0034969)2.56960265
151regulation of glucocorticoid secretion (GO:2000849)2.56514813
152endocytic recycling (GO:0032456)2.55902468
153positive regulation of protein kinase C signaling (GO:0090037)2.49069601
154genitalia morphogenesis (GO:0035112)2.46895106
155cornea development in camera-type eye (GO:0061303)2.44391073
156microglial cell activation (GO:0001774)2.44353606
157G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.44196751
158nucleoside diphosphate phosphorylation (GO:0006165)2.42566015
159RNA destabilization (GO:0050779)2.41050707
160positive regulation of macrophage activation (GO:0043032)2.37155399
161lactate metabolic process (GO:0006089)2.36520448
162regulation of cytokine production involved in inflammatory response (GO:1900015)2.35331436
163peptidyl-glutamic acid modification (GO:0018200)2.33098195
164left/right axis specification (GO:0070986)2.32913043
165regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.32303022
166regulation of spindle checkpoint (GO:0090231)2.32156231
167RNA localization (GO:0006403)2.27465325
168startle response (GO:0001964)2.26640209
169fucose catabolic process (GO:0019317)2.24590156
170L-fucose metabolic process (GO:0042354)2.24590156
171L-fucose catabolic process (GO:0042355)2.24590156
172appendage development (GO:0048736)2.23210300
173limb development (GO:0060173)2.23210300
174protein-chromophore linkage (GO:0018298)13.2513929
175* sperm motility (GO:0030317)11.6133903
176fusion of sperm to egg plasma membrane (GO:0007342)11.5848982
177response to pheromone (GO:0019236)10.9711750
178acrosome reaction (GO:0007340)10.3960625
179cell wall macromolecule catabolic process (GO:0016998)10.3727954
180cell wall macromolecule metabolic process (GO:0044036)10.3727954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.91858377
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.83614393
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32859164
4EZH2_22144423_ChIP-Seq_EOC_Human3.98895513
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.36585522
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30151560
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.27472896
8PCGF2_27294783_Chip-Seq_ESCs_Mouse3.05257989
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96164019
10VDR_22108803_ChIP-Seq_LS180_Human2.50110195
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48316836
12EGR1_19032775_ChIP-ChIP_M12_Human2.35030670
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.33778645
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.24538211
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.23458691
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.16535721
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14471870
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13558352
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.11918722
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.08384379
21NANOG_20526341_ChIP-Seq_ESCs_Human2.02113991
22AR_21572438_ChIP-Seq_LNCaP_Human1.94860411
23TAF15_26573619_Chip-Seq_HEK293_Human1.87764012
24RAC3_21632823_ChIP-Seq_H3396_Human1.86588219
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.86274039
26BCOR_27268052_Chip-Seq_Bcells_Human1.86211907
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.85301071
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.83950620
29* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81990369
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.79886061
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79555585
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77864367
33AR_20517297_ChIP-Seq_VCAP_Human1.74618232
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.72052764
35* CTCF_27219007_Chip-Seq_Bcells_Human1.69777423
36GBX2_23144817_ChIP-Seq_PC3_Human1.69143797
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.68614717
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66753240
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66512201
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62952983
41P53_22387025_ChIP-Seq_ESCs_Mouse1.60087322
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.59635837
43STAT1_17558387_ChIP-Seq_HELA_Human1.57377834
44KDM2B_26808549_Chip-Seq_REH_Human1.55322644
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55220672
46SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54579945
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52796103
48* BCL6_27268052_Chip-Seq_Bcells_Human1.52459879
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.52403772
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.52243228
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51890336
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51362526
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.51224430
54P300_18555785_Chip-Seq_ESCs_Mouse1.50395877
55TAF2_19829295_ChIP-Seq_ESCs_Human1.49295746
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49191002
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.47425863
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.46040886
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45793500
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45630976
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.43982390
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43811970
63OCT4_20526341_ChIP-Seq_ESCs_Human1.42307020
64RNF2_27304074_Chip-Seq_NSC_Mouse1.42292629
65ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42064854
66DROSHA_22980978_ChIP-Seq_HELA_Human1.41508991
67* SA1_27219007_Chip-Seq_Bcells_Human1.41246404
68SMC4_20622854_ChIP-Seq_HELA_Human1.40412677
69PU1_27457419_Chip-Seq_LIVER_Mouse1.40180724
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39994543
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39994543
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.39611633
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.39297243
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.39193285
75NANOG_19829295_ChIP-Seq_ESCs_Human1.38053076
76SOX2_19829295_ChIP-Seq_ESCs_Human1.38053076
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.37922232
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37555968
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.36780373
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.35063597
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33807132
82MYC_19829295_ChIP-Seq_ESCs_Human1.32891897
83FUS_26573619_Chip-Seq_HEK293_Human1.32232330
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29493490
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28949074
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28876672
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.28628569
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28429304
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28335098
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.27800642
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27328359
92AR_25329375_ChIP-Seq_VCAP_Human1.25447708
93P300_19829295_ChIP-Seq_ESCs_Human1.25283563
94CDX2_22108803_ChIP-Seq_LS180_Human1.25261744
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.25158355
96CIITA_25753668_ChIP-Seq_RAJI_Human1.25145430
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.23996616
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23996616
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22602161
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21508366
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21289993
102CBP_20019798_ChIP-Seq_JUKART_Human1.21289993
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.20847709
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20344474
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19597400
106ERG_20517297_ChIP-Seq_VCAP_Human1.19227408
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16828016
108RXR_22108803_ChIP-Seq_LS180_Human1.16611303
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16552738
110ERA_21632823_ChIP-Seq_H3396_Human1.16260687
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15531213
112* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14762381
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.14368207
114REST_21632747_ChIP-Seq_MESCs_Mouse1.14019981
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13985536
116ER_23166858_ChIP-Seq_MCF-7_Human1.13875525
117GF1_26923725_Chip-Seq_HPCs_Mouse1.12581504
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12399247
119* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11518089
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10764528
121GATA3_21867929_ChIP-Seq_CD8_Mouse1.10435091
122WDR5_24793694_ChIP-Seq_LNCAP_Human1.10411151
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08831349
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08831349
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08831349
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07606139
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05354446
128SMAD4_21799915_ChIP-Seq_A2780_Human1.04677447
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04310975
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04259963
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03449768
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.02659080
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.01992400
134GATA3_21867929_ChIP-Seq_TH1_Mouse1.01881696
135RUNX2_22187159_ChIP-Seq_PCA_Human1.01593712
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01333438
137* HNFA_21074721_ChIP-Seq_CACO-2_Human1.01121307
138HOXB7_26014856_ChIP-Seq_BT474_Human1.01069614
139E2F1_20622854_ChIP-Seq_HELA_Human0.99758185
140NCOR_22424771_ChIP-Seq_293T_Human0.98784634
141ZNF274_21170338_ChIP-Seq_K562_Hela0.98122598
142EZH2_27294783_Chip-Seq_ESCs_Mouse0.98029300
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97430297
144* ETV1_20927104_ChIP-Seq_GIST48_Human0.96887378
145GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96318031
146SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96000472
147ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95954942
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95762946
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95544476
150STAT3_23295773_ChIP-Seq_U87_Human0.95456497
151* NFYB_21822215_ChIP-Seq_K562_Human0.95161228
152* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95042328
153CBP_21632823_ChIP-Seq_H3396_Human0.94298576
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91614858
155SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91001784
156ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90930346
157TCF4_23295773_ChIP-Seq_U87_Human0.90841422
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90219016
159SMRT_27268052_Chip-Seq_Bcells_Human0.89016405
160* PHF8_20622853_ChIP-Seq_HELA_Human0.88656840
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87952393
162TCF4_22108803_ChIP-Seq_LS180_Human0.87684605
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.87660196
164STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87636490
165* SPI1_20517297_ChIP-Seq_HL60_Human0.86949869
166* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86549700
167ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86530383
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86472566
169RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86132206
170* P53_21459846_ChIP-Seq_SAOS-2_Human0.85948744
171CEBPB_22108803_ChIP-Seq_LS180_Human0.85619414
172FOXH1_21741376_ChIP-Seq_EPCs_Human0.85154679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive4.59733237
2* MP0001929_abnormal_gametogenesis4.00297834
3MP0000372_irregular_coat_pigmentation3.74714224
4MP0002822_catalepsy3.43727881
5MP0004043_abnormal_pH_regulation3.25341438
6MP0005670_abnormal_white_adipose3.18451493
7MP0008877_abnormal_DNA_methylation3.00808842
8MP0008057_abnormal_DNA_replication2.99970360
9MP0001502_abnormal_circadian_rhythm2.79196646
10MP0001661_extended_life_span2.75181748
11MP0003191_abnormal_cellular_cholesterol2.57886369
12MP0002210_abnormal_sex_determination2.52572230
13MP0000566_synostosis2.38768373
14* MP0002161_abnormal_fertility/fecundity2.28882588
15MP0003787_abnormal_imprinting2.19804237
16MP0005410_abnormal_fertilization12.9657709
17MP0001145_abnormal_male_reproductive1.91203604
18MP0002102_abnormal_ear_morphology1.87104800
19MP0006292_abnormal_olfactory_placode1.85830869
20MP0004142_abnormal_muscle_tone1.75059638
21MP0003950_abnormal_plasma_membrane1.73609888
22MP0002282_abnormal_trachea_morphology1.72427158
23MP0000653_abnormal_sex_gland1.69696771
24MP0001986_abnormal_taste_sensitivity1.66447708
25MP0001984_abnormal_olfaction1.65383743
26MP0008995_early_reproductive_senescence1.64584356
27MP0001835_abnormal_antigen_presentation1.62981304
28MP0003123_paternal_imprinting1.58551304
29MP0003806_abnormal_nucleotide_metabolis1.56495804
30MP0003011_delayed_dark_adaptation1.55656837
31MP0002277_abnormal_respiratory_mucosa1.52545942
32MP0003136_yellow_coat_color1.48242932
33MP0002148_abnormal_hypersensitivity_rea1.47899005
34MP0009780_abnormal_chondrocyte_physiolo1.46937587
35MP0002138_abnormal_hepatobiliary_system1.44484149
36MP0005646_abnormal_pituitary_gland1.43871860
37MP0004381_abnormal_hair_follicle1.37212793
38MP0001905_abnormal_dopamine_level1.32003631
39MP0005647_abnormal_sex_gland1.30608016
40MP0003941_abnormal_skin_development1.29134753
41MP0002653_abnormal_ependyma_morphology1.28354276
42MP0000516_abnormal_urinary_system1.27333157
43MP0005367_renal/urinary_system_phenotyp1.27333157
44MP0005409_darkened_coat_color1.23596552
45MP0005551_abnormal_eye_electrophysiolog1.23460508
46MP0003718_maternal_effect1.22994780
47MP0002876_abnormal_thyroid_physiology1.22199361
48MP0005376_homeostasis/metabolism_phenot1.21044816
49MP0005379_endocrine/exocrine_gland_phen1.13565388
50MP0004185_abnormal_adipocyte_glucose1.13256762
51MP0000383_abnormal_hair_follicle1.13116754
52MP0010386_abnormal_urinary_bladder1.10225376
53MP0002160_abnormal_reproductive_system1.09925872
54MP0000678_abnormal_parathyroid_gland1.09664120
55MP0002132_abnormal_respiratory_system1.08339109
56MP0005377_hearing/vestibular/ear_phenot1.06876552
57MP0003878_abnormal_ear_physiology1.06876552
58MP0004215_abnormal_myocardial_fiber1.04579580
59MP0000537_abnormal_urethra_morphology1.02272131
60MP0008872_abnormal_physiological_respon1.02034130
61MP0002249_abnormal_larynx_morphology0.99268729
62MP0005253_abnormal_eye_physiology0.98263134
63MP0003786_premature_aging0.97996232
64MP0005671_abnormal_response_to0.97860072
65MP0006138_congestive_heart_failure0.97393914
66MP0003252_abnormal_bile_duct0.96616135
67MP0002928_abnormal_bile_duct0.94835397
68MP0002163_abnormal_gland_morphology0.94599403
69MP0008004_abnormal_stomach_pH0.92932582
70MP0002234_abnormal_pharynx_morphology0.92690733
71MP0002638_abnormal_pupillary_reflex0.92334195
72MP0008058_abnormal_DNA_repair0.90473535
73MP0001188_hyperpigmentation0.90403844
74MP0002735_abnormal_chemical_nociception0.89740869
75MP0001790_abnormal_immune_system0.88280571
76MP0005387_immune_system_phenotype0.88280571
77MP0009046_muscle_twitch0.86969939
78MP0003119_abnormal_digestive_system0.82566736
79MP0002693_abnormal_pancreas_physiology0.81635712
80MP0005195_abnormal_posterior_eye0.81022835
81MP0000681_abnormal_thyroid_gland0.79818253
82MP0004147_increased_porphyrin_level0.79373152
83MP0005503_abnormal_tendon_morphology0.77865427
84MP0006072_abnormal_retinal_apoptosis0.77811079
85MP0006082_CNS_inflammation0.74478251
86MP0009785_altered_susceptibility_to0.74384586
87MP0002736_abnormal_nociception_after0.73486680
88MP0009333_abnormal_splenocyte_physiolog0.72595135
89MP0004085_abnormal_heartbeat0.72562693
90MP0003436_decreased_susceptibility_to0.72400674
91MP0009250_abnormal_appendicular_skeleto0.71577305
92MP0003724_increased_susceptibility_to0.70809861
93MP0008775_abnormal_heart_ventricle0.70544984
94MP0000049_abnormal_middle_ear0.69866963
95MP0002752_abnormal_somatic_nervous0.69719212
96MP0008874_decreased_physiological_sensi0.69212679
97MP0004130_abnormal_muscle_cell0.68588046
98MP0001968_abnormal_touch/_nociception0.67846737
99MP0009745_abnormal_behavioral_response0.67363819
100MP0005623_abnormal_meninges_morphology0.67358020
101MP0000026_abnormal_inner_ear0.67247015
102MP0004742_abnormal_vestibular_system0.66994504
103MP0005075_abnormal_melanosome_morpholog0.66949146
104MP0005266_abnormal_metabolism0.66907952
105MP0004782_abnormal_surfactant_physiolog0.66174597
106MP0009053_abnormal_anal_canal0.66136805
107MP0005451_abnormal_body_composition0.66026999
108MP0001765_abnormal_ion_homeostasis0.63522253
109MP0002405_respiratory_system_inflammati0.63205188
110MP0001348_abnormal_lacrimal_gland0.61594026
111MP0003045_fibrosis0.60809546
112MP0001764_abnormal_homeostasis0.58797488
113MP0003121_genomic_imprinting0.58724532
114MP0005174_abnormal_tail_pigmentation0.58489039
115MP0001324_abnormal_eye_pigmentation0.56870715
116MP0001486_abnormal_startle_reflex0.55555597
117MP0002109_abnormal_limb_morphology0.53292772
118MP0003936_abnormal_reproductive_system0.53170387
119MP0001346_abnormal_lacrimal_gland0.52878675
120MP0005389_reproductive_system_phenotype0.52737149
121MP0000613_abnormal_salivary_gland0.51965504
122MP0002229_neurodegeneration0.51858956
123MP0009379_abnormal_foot_pigmentation0.51633116
124MP0004134_abnormal_chest_morphology0.51512806
125MP0001270_distended_abdomen0.50937475
126MP0005025_abnormal_response_to0.50785931
127MP0002098_abnormal_vibrissa_morphology0.50708580
128MP0000762_abnormal_tongue_morphology0.50329290
129MP0005423_abnormal_somatic_nervous0.50153046
130MP0004019_abnormal_vitamin_homeostasis0.50086189
131MP0005310_abnormal_salivary_gland0.48419639
132MP0002419_abnormal_innate_immunity0.47700917
133MP0003942_abnormal_urinary_system0.47359557
134MP0005666_abnormal_adipose_tissue0.47125602
135MP0005000_abnormal_immune_tolerance0.46960060
136MP0001533_abnormal_skeleton_physiology0.46026237
137MP0001529_abnormal_vocalization0.44726226
138MP0003646_muscle_fatigue0.44476208
139MP0002127_abnormal_cardiovascular_syste0.43174955
140MP0000631_abnormal_neuroendocrine_gland0.43164261
141MP0004036_abnormal_muscle_relaxation0.42511165
142MP0005391_vision/eye_phenotype0.42364654
143MP0003935_abnormal_craniofacial_develop0.42168198
144MP0002067_abnormal_sensory_capabilities0.41872014
145MP0000538_abnormal_urinary_bladder0.41814149
146MP0000432_abnormal_head_morphology0.41460043
147MP0008875_abnormal_xenobiotic_pharmacok0.41397629
148MP0002733_abnormal_thermal_nociception0.41167535
149MP0000639_abnormal_adrenal_gland0.40758760
150MP0002095_abnormal_skin_pigmentation0.40286802
151MP0009384_cardiac_valve_regurgitation0.38352145
152MP0003137_abnormal_impulse_conducting0.38291213
153MP0005408_hypopigmentation0.38277013
154MP0003938_abnormal_ear_development0.37848789
155MP0000703_abnormal_thymus_morphology0.37256395
156MP0002909_abnormal_adrenal_gland0.36763933
157MP0001963_abnormal_hearing_physiology0.35870139
158MP0002332_abnormal_exercise_endurance0.35723161
159MP0002933_joint_inflammation0.35399945
160MP0004145_abnormal_muscle_electrophysio0.33264758
161MP0003315_abnormal_perineum_morphology0.33173110
162MP0003633_abnormal_nervous_system0.33148524
163MP0002233_abnormal_nose_morphology0.33098742
164MP0000470_abnormal_stomach_morphology0.32664978

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.04337993
2Abnormal respiratory epithelium morphology (HP:0012253)8.04337993
3Abnormal respiratory motile cilium physiology (HP:0012261)7.71978780
4Abnormality of dentin (HP:0010299)7.58861360
5Hyperactive renin-angiotensin system (HP:0000841)6.67718960
6Abnormal ciliary motility (HP:0012262)6.64216607
7Tinnitus (HP:0000360)6.02294041
8Rhinitis (HP:0012384)5.97164080
9Chronic bronchitis (HP:0004469)5.37750752
10Hypokalemic alkalosis (HP:0001949)4.90455862
11Abnormal rod and cone electroretinograms (HP:0008323)4.80493471
12Infertility (HP:0000789)4.61880351
13Renal salt wasting (HP:0000127)4.39458777
14Nasal polyposis (HP:0100582)4.34157546
15Abnormality of chloride homeostasis (HP:0011422)3.88956406
16Decreased circulating renin level (HP:0003351)3.80629144
17Bronchiectasis (HP:0002110)3.77890706
18Hyperaldosteronism (HP:0000859)3.74972504
19Severe visual impairment (HP:0001141)3.73964640
20Conical tooth (HP:0000698)3.44142870
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41840513
22Squamous cell carcinoma (HP:0002860)3.41419680
23Nephronophthisis (HP:0000090)3.37234251
24IgM deficiency (HP:0002850)3.36795878
25Multiple enchondromatosis (HP:0005701)3.32397620
26Hyponatremia (HP:0002902)3.30995383
27Abnormality of the nasal mucosa (HP:0000433)3.26459101
28Abnormal spermatogenesis (HP:0008669)3.23172679
29Abnormality of renin-angiotensin system (HP:0000847)3.18961842
30Recurrent sinusitis (HP:0011108)3.18569842
31Bronchitis (HP:0012387)3.14266511
32Tubulointerstitial nephritis (HP:0001970)3.13236625
33Pancreatic cysts (HP:0001737)3.02509067
34Abnormality of the renal medulla (HP:0100957)2.98496581
35Abnormality of incisor morphology (HP:0011063)2.94936186
36Congenital stationary night blindness (HP:0007642)2.94731439
37Hypokalemia (HP:0002900)2.89409781
38Increased circulating renin level (HP:0000848)2.87370575
39Confusion (HP:0001289)2.81770749
40Onycholysis (HP:0001806)2.75054736
41Abnormality of sodium homeostasis (HP:0010931)2.65746598
42Azoospermia (HP:0000027)2.64411562
43Decreased central vision (HP:0007663)2.62561985
44Sclerocornea (HP:0000647)2.57919188
45Medial flaring of the eyebrow (HP:0010747)2.53226319
46Recurrent otitis media (HP:0000403)2.46975352
47Male infertility (HP:0003251)2.46726519
48Molar tooth sign on MRI (HP:0002419)2.46381642
49Abnormality of midbrain morphology (HP:0002418)2.46381642
50Constricted visual fields (HP:0001133)2.45486516
51Fibular hypoplasia (HP:0003038)2.42102933
52Abnormality of macular pigmentation (HP:0008002)2.41625346
53Hyperlipoproteinemia (HP:0010980)2.39998985
54Bony spicule pigmentary retinopathy (HP:0007737)2.39269736
55Bell-shaped thorax (HP:0001591)2.37968476
56Alkalosis (HP:0001948)2.36663235
57Pendular nystagmus (HP:0012043)2.35979669
58Spontaneous hematomas (HP:0007420)2.32975067
59Widely patent fontanelles and sutures (HP:0004492)2.28790312
60Abnormality of the parietal bone (HP:0002696)2.28458964
61IgG deficiency (HP:0004315)2.25354186
62Abnormal cartilage morphology (HP:0002763)2.25191076
63Chronic hepatic failure (HP:0100626)2.24924584
64Metabolic alkalosis (HP:0200114)2.24569289
65Tubulointerstitial abnormality (HP:0001969)2.24068266
66Preauricular pit (HP:0004467)2.21508412
67Periauricular skin pits (HP:0100277)2.21508412
68Central scotoma (HP:0000603)2.20371345
69Abolished electroretinogram (ERG) (HP:0000550)2.19762082
70Dyschromatopsia (HP:0007641)2.17889843
71Abnormality of potassium homeostasis (HP:0011042)2.15301590
72Epidermoid cyst (HP:0200040)2.13098201
73Resting tremor (HP:0002322)2.12215774
74Polyuria (HP:0000103)2.12119995
75Occipital encephalocele (HP:0002085)2.11068008
76Rectal prolapse (HP:0002035)2.11024193
77Mixed hearing impairment (HP:0000410)2.06800491
78True hermaphroditism (HP:0010459)2.06620140
79Abnormal urine output (HP:0012590)2.01935942
80Tubular atrophy (HP:0000092)2.00285547
81Dynein arm defect of respiratory motile cilia (HP:0012255)11.7100569
82Absent/shortened dynein arms (HP:0200106)11.7100569
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6925318
84Bilateral sensorineural hearing impairment (HP:0008619)10.4567660
85Sensorimotor neuropathy (HP:0007141)1.99578245
86Absent epiphyses (HP:0010577)1.93200721
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93200721
88Abnormality of the renal cortex (HP:0011035)1.92503783
89Abnormality of the dental pulp (HP:0006479)1.91406749
90Congenital hepatic fibrosis (HP:0002612)1.91309548
91Urinary bladder sphincter dysfunction (HP:0002839)1.89581244
92Dry hair (HP:0011359)1.89499126
93Absent frontal sinuses (HP:0002688)1.89486744
94Epiphyseal dysplasia (HP:0002656)1.86710228
95Aplasia/Hypoplasia of the macula (HP:0008059)1.86655213
96Renal dysplasia (HP:0000110)1.86489978
97Impulsivity (HP:0100710)1.84470897
98Type 2 muscle fiber atrophy (HP:0003554)1.84380750
99Concave nail (HP:0001598)1.84142834
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83914415
101Postaxial foot polydactyly (HP:0001830)1.82387052
102Status epilepticus (HP:0002133)1.81479271
103Irregular epiphyses (HP:0010582)1.81471184
104Gonadotropin excess (HP:0000837)1.81319098
105Retrobulbar optic neuritis (HP:0100654)1.80768606
106Optic neuritis (HP:0100653)1.80768606
107Attenuation of retinal blood vessels (HP:0007843)1.80181417
108Stage 5 chronic kidney disease (HP:0003774)1.79907233
109Vitreoretinal degeneration (HP:0000655)1.78341350
110Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78207841
111Male pseudohermaphroditism (HP:0000037)1.76651796
112Chronic sinusitis (HP:0011109)1.76331211
113Aplasia cutis congenita (HP:0001057)1.75676752
114Abnormality of the neuromuscular junction (HP:0003398)1.75545623
115Fatigable weakness (HP:0003473)1.75545623
116Bile duct proliferation (HP:0001408)1.75101272
117Abnormal biliary tract physiology (HP:0012439)1.75101272
118Optic nerve hypoplasia (HP:0000609)1.75037267
119Short thorax (HP:0010306)1.73013349
120Abdominal situs inversus (HP:0003363)1.72337180
121Abnormality of abdominal situs (HP:0011620)1.72337180
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70984113
123Nephropathy (HP:0000112)1.70788477
124Short femoral neck (HP:0100864)1.70713648
125Scotoma (HP:0000575)1.70075418
126Aplasia/Hypoplasia affecting the retina (HP:0008061)1.69648575
127Anencephaly (HP:0002323)1.68153351
128Recurrent bronchitis (HP:0002837)1.65277017
129Abnormality of the dental root (HP:0006486)1.65023215
130Taurodontia (HP:0000679)1.65023215
131Abnormality of permanent molar morphology (HP:0011071)1.65023215
132Abnormality of molar morphology (HP:0011070)1.63496037
133Abnormality of molar (HP:0011077)1.63496037
134Median cleft lip (HP:0000161)1.63477021
135Absent eyebrow (HP:0002223)1.62462377
136Self-mutilation (HP:0000742)1.60282561
137Orchitis (HP:0100796)1.60215057
138Nonprogressive disorder (HP:0003680)1.59895848
139Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.59879753
140Supernumerary spleens (HP:0009799)1.59829374
141Septo-optic dysplasia (HP:0100842)1.59608036
142Preaxial hand polydactyly (HP:0001177)1.59496947
143Tubulointerstitial fibrosis (HP:0005576)1.58422632
144Duplicated collecting system (HP:0000081)1.57223548
145Hypoplastic ischia (HP:0003175)1.57200859
146Chorioretinal atrophy (HP:0000533)1.56905756
147Aplasia/Hypoplasia of the lens (HP:0008063)1.54911554
148Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.54608946
149Muscle fiber atrophy (HP:0100295)1.54054343
150Abnormality of the frontal sinuses (HP:0002687)1.52808581
151Facial cleft (HP:0002006)1.51748434
152Upper limb muscle weakness (HP:0003484)1.49588843
153Pancreatic fibrosis (HP:0100732)1.48846026
154Abnormality of renal excretion (HP:0011036)1.47074161
155Oculomotor apraxia (HP:0000657)1.45749947
15611 pairs of ribs (HP:0000878)1.45408193
157Cystic liver disease (HP:0006706)1.44967424
158Abnormal drinking behavior (HP:0030082)1.43648173
159Polydipsia (HP:0001959)1.43648173
160Amelogenesis imperfecta (HP:0000705)1.43571138
161Chromsome breakage (HP:0040012)1.42220585
162Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.41154860
163Abnormality of renal resorption (HP:0011038)1.39754186
164Optic disc pallor (HP:0000543)1.39682399
165Congenital sensorineural hearing impairment (HP:0008527)1.38388546
166Aplasia/Hypoplasia of the fibula (HP:0006492)1.38081503
167Alveolar cell carcinoma (HP:0006519)1.37353792
168Cone-rod dystrophy (HP:0000548)1.34838321
169Hyperkalemia (HP:0002153)1.34577993
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.33949297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.79584778
2PDK35.79584778
3SIK15.65523387
4SIK25.32759826
5TESK14.68702149
6PDK24.56116076
7CDK193.29580037
8CASK3.09554871
9ICK2.94767200
10NEK12.86866293
11MARK32.84187945
12PRKD32.77389622
13DDR22.31457462
14TESK22.14200901
15WNK41.93229279
16NLK1.92320718
17JAK31.90774314
18MAP3K111.87785342
19MAP3K101.75552726
20MAP3K141.75439661
21STK38L1.61516797
22TXK1.61319876
23ADRBK21.61231267
24CDK81.60992836
25STK391.50659459
26MAP2K61.49704546
27GRK71.48421531
28MELK1.47726719
29IRAK41.44602349
30CCNB11.41453047
31TAOK21.41379402
32NEK61.38980929
33INSRR1.38465705
34MUSK1.34647945
35IRAK11.33028666
36TRPM71.30559967
37BMPR21.21369435
38STK381.19329774
39PINK11.16362790
40IRAK21.14423705
41YES11.13322407
42MAPK151.11771819
43ITK1.05909879
44CDK31.05174125
45ZAK1.04931061
46BLK1.04892810
47RIPK41.04216382
48PTK2B1.03629001
49LATS11.02857910
50MST1R1.02532151
51FGR1.01194985
52DYRK1B0.99276714
53PRKAA10.94178113
54EIF2AK20.91071709
55TAOK30.89798344
56STK160.89201852
57MAP3K30.84513544
58KIT0.83996875
59MAP3K70.83817099
60BRSK20.79186087
61PRPF4B0.78660977
62ERBB40.76908479
63FRK0.75390526
64CHEK20.74607638
65MST40.73912116
66MARK20.71762979
67EPHB20.71083007
68GRK10.70661715
69PLK20.69442560
70TNK20.69222437
71WNK10.69142931
72IKBKB0.68135329
73PDK10.67585595
74PLK30.67490332
75STK30.67388767
76OXSR10.63373968
77PNCK0.63016361
78STK240.61505358
79VRK10.59804803
80MKNK20.58703544
81PLK40.58533419
82MAP2K70.57440090
83NME10.57005982
84CDK40.56593790
85IRAK30.55163042
86CDK90.52904527
87LCK0.52528251
88IKBKE0.52346515
89BTK0.52315350
90TGFBR10.52228301
91TNIK0.50862157
92BCR0.50450892
93TEC0.49279712
94PBK0.47318360
95NEK20.46109069
96CLK10.45841956
97CSK0.45565271
98SIK30.45539790
99MAP2K20.44890204
100MAPK70.43147324
101OBSCN0.42203477
102CAMK10.41275432
103ERBB20.39598676
104NUAK10.39233430
105MAPKAPK50.39219591
106PRKCB0.38082432
107PKN10.37532927
108EIF2AK30.35844614
109PASK0.35779796
110BRD40.35681431
111FGFR40.35426263
112DYRK1A0.34708096
113MKNK10.34199032
114ATR0.34012329
115STK110.33721627
116SRPK10.33245440
117VRK20.32904817
118TSSK60.32781728
119MAP3K50.32680057
120RPS6KB10.32381275
121EGFR0.32348097
122CAMKK20.32178578
123PRKG20.31990670
124NTRK30.31701757
125LMTK20.31212217
126TTK0.31086055
127PRKCH0.29895203
128PRKG10.28573716
129PRKCQ0.28497646
130DYRK30.28349145
131PRKCG0.27955599
132LYN0.27156014
133PIK3CA0.26350665
134WNK30.26266436
135TIE10.25875711
136PRKCE0.25106069
137PRKCD0.24668841
138PRKCZ0.24118902
139CAMKK10.23426965
140TYK20.23323531
141PRKACA0.22476650
142MAP4K20.21481938
143ATM0.21220213
144CDK70.21126770
145ERBB30.20057919
146PLK10.19695033
147RPS6KA60.18898022
148BMPR1B0.18886131
149PDPK10.17877642
150PIK3CG0.17485857
151MAPK110.17328778
152PRKACB0.17327831
153PHKG20.16472641
154PHKG10.16472641
155RPS6KA50.16215520
156PRKAA20.13986569
157CAMK1D0.13821709
158PRKCA0.13630560
159MAPK140.12647651

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.25201810
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.08780512
3Linoleic acid metabolism_Homo sapiens_hsa005913.05165614
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04866316
5Caffeine metabolism_Homo sapiens_hsa002322.80868669
6Fatty acid biosynthesis_Homo sapiens_hsa000612.63358620
7Selenocompound metabolism_Homo sapiens_hsa004502.58502003
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.42086137
9Arachidonic acid metabolism_Homo sapiens_hsa005902.40982078
10Folate biosynthesis_Homo sapiens_hsa007902.35991800
11Fanconi anemia pathway_Homo sapiens_hsa034602.35578802
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.17900097
13Ether lipid metabolism_Homo sapiens_hsa005652.10773105
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89579958
15Basal transcription factors_Homo sapiens_hsa030221.88018243
16Sphingolipid metabolism_Homo sapiens_hsa006001.84469310
17Other glycan degradation_Homo sapiens_hsa005111.81510432
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76013657
19Protein export_Homo sapiens_hsa030601.75844142
20Phototransduction_Homo sapiens_hsa047441.64310773
21GABAergic synapse_Homo sapiens_hsa047271.64278033
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64215398
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61453101
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60226435
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59578913
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59467898
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.53597725
28Taste transduction_Homo sapiens_hsa047421.49125536
29Autoimmune thyroid disease_Homo sapiens_hsa053201.47442733
30Nitrogen metabolism_Homo sapiens_hsa009101.38774359
31Mineral absorption_Homo sapiens_hsa049781.36452799
32Ribosome_Homo sapiens_hsa030101.36188460
33RNA transport_Homo sapiens_hsa030131.36140560
34Allograft rejection_Homo sapiens_hsa053301.35701144
35Nicotine addiction_Homo sapiens_hsa050331.35694369
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.30879235
37Vitamin B6 metabolism_Homo sapiens_hsa007501.29680988
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29161607
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22713554
40Purine metabolism_Homo sapiens_hsa002301.18990203
41Protein digestion and absorption_Homo sapiens_hsa049741.17557937
42Sulfur metabolism_Homo sapiens_hsa009201.15293018
43RNA polymerase_Homo sapiens_hsa030201.14705082
44Amphetamine addiction_Homo sapiens_hsa050311.13976370
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.13551443
46Homologous recombination_Homo sapiens_hsa034401.11738286
47Peroxisome_Homo sapiens_hsa041461.11451714
48Primary immunodeficiency_Homo sapiens_hsa053401.08648370
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07531684
50Pyruvate metabolism_Homo sapiens_hsa006201.05577163
51Huntingtons disease_Homo sapiens_hsa050161.03858127
52Rheumatoid arthritis_Homo sapiens_hsa053231.02719192
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.00915538
54Hedgehog signaling pathway_Homo sapiens_hsa043401.00330989
55Graft-versus-host disease_Homo sapiens_hsa053321.00108236
56Basal cell carcinoma_Homo sapiens_hsa052170.97692721
57Glucagon signaling pathway_Homo sapiens_hsa049220.97595761
58Arginine and proline metabolism_Homo sapiens_hsa003300.96631877
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96409136
60Cholinergic synapse_Homo sapiens_hsa047250.95586156
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93418535
62Renin secretion_Homo sapiens_hsa049240.92800470
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92327521
64Calcium signaling pathway_Homo sapiens_hsa040200.91690472
65Cardiac muscle contraction_Homo sapiens_hsa042600.91479731
66Regulation of autophagy_Homo sapiens_hsa041400.91441290
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91255393
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90594067
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90302214
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.90051841
71Glycerolipid metabolism_Homo sapiens_hsa005610.90000055
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88633526
73Glutathione metabolism_Homo sapiens_hsa004800.88181174
74Collecting duct acid secretion_Homo sapiens_hsa049660.87995730
75Antigen processing and presentation_Homo sapiens_hsa046120.86460951
76Proteasome_Homo sapiens_hsa030500.85918054
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85648768
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82032610
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81385312
80Asthma_Homo sapiens_hsa053100.81329416
81Dorso-ventral axis formation_Homo sapiens_hsa043200.78757490
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78434072
83Legionellosis_Homo sapiens_hsa051340.78232482
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77938962
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76311387
86Chemical carcinogenesis_Homo sapiens_hsa052040.76302007
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74736094
88Wnt signaling pathway_Homo sapiens_hsa043100.73952521
89Butanoate metabolism_Homo sapiens_hsa006500.73003318
90TGF-beta signaling pathway_Homo sapiens_hsa043500.72548141
91Vitamin digestion and absorption_Homo sapiens_hsa049770.72502277
92Morphine addiction_Homo sapiens_hsa050320.70905068
93PPAR signaling pathway_Homo sapiens_hsa033200.70680093
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.70443520
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69738521
96Insulin secretion_Homo sapiens_hsa049110.69370763
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66154831
98Melanogenesis_Homo sapiens_hsa049160.65352353
99Herpes simplex infection_Homo sapiens_hsa051680.64475142
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64293735
101Malaria_Homo sapiens_hsa051440.63641734
102Measles_Homo sapiens_hsa051620.63347632
103Type I diabetes mellitus_Homo sapiens_hsa049400.62926070
104Hippo signaling pathway_Homo sapiens_hsa043900.61875636
105Oxidative phosphorylation_Homo sapiens_hsa001900.60674567
106Hematopoietic cell lineage_Homo sapiens_hsa046400.59643507
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58634921
108Retinol metabolism_Homo sapiens_hsa008300.58330267
109Fructose and mannose metabolism_Homo sapiens_hsa000510.57261020
110Pancreatic secretion_Homo sapiens_hsa049720.56681911
111Endocytosis_Homo sapiens_hsa041440.56435268
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.55429147
113Gastric acid secretion_Homo sapiens_hsa049710.53822539
114Glutamatergic synapse_Homo sapiens_hsa047240.53271156
115Fat digestion and absorption_Homo sapiens_hsa049750.52252740
116cAMP signaling pathway_Homo sapiens_hsa040240.50908003
117ABC transporters_Homo sapiens_hsa020100.50775225
118Base excision repair_Homo sapiens_hsa034100.50726774
119Phagosome_Homo sapiens_hsa041450.50647934
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.50563411
121Bile secretion_Homo sapiens_hsa049760.48809515
122Propanoate metabolism_Homo sapiens_hsa006400.48362394
123RNA degradation_Homo sapiens_hsa030180.46868136
124Serotonergic synapse_Homo sapiens_hsa047260.46842874
125Circadian entrainment_Homo sapiens_hsa047130.44838371
126Alcoholism_Homo sapiens_hsa050340.44813510
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44584332
128Fatty acid elongation_Homo sapiens_hsa000620.44273799
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44052941
130Thyroid hormone synthesis_Homo sapiens_hsa049180.43861321
131ECM-receptor interaction_Homo sapiens_hsa045120.43554424
132Olfactory transduction_Homo sapiens_hsa047400.43096560
133Salivary secretion_Homo sapiens_hsa049700.42334313
134Alzheimers disease_Homo sapiens_hsa050100.42122307
135Tryptophan metabolism_Homo sapiens_hsa003800.41691508
136Toxoplasmosis_Homo sapiens_hsa051450.41182625
137TNF signaling pathway_Homo sapiens_hsa046680.39839049
138Metabolic pathways_Homo sapiens_hsa011000.39155197
139Influenza A_Homo sapiens_hsa051640.38717119
140Systemic lupus erythematosus_Homo sapiens_hsa053220.38103429
141Inositol phosphate metabolism_Homo sapiens_hsa005620.38048769
142Cocaine addiction_Homo sapiens_hsa050300.37848234
143Pyrimidine metabolism_Homo sapiens_hsa002400.37348117
144African trypanosomiasis_Homo sapiens_hsa051430.36650919
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33803845
146Ovarian steroidogenesis_Homo sapiens_hsa049130.33219731
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32695095
148mRNA surveillance pathway_Homo sapiens_hsa030150.32112986
149Chemokine signaling pathway_Homo sapiens_hsa040620.30833033
150Pathways in cancer_Homo sapiens_hsa052000.30770473
151Thyroid cancer_Homo sapiens_hsa052160.30308864

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