CATSPERD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.93312474
2binding of sperm to zona pellucida (GO:0007339)9.72313427
3plasma membrane fusion (GO:0045026)9.43892815
4motile cilium assembly (GO:0044458)9.24481916
5cell wall macromolecule catabolic process (GO:0016998)9.24210072
6cell wall macromolecule metabolic process (GO:0044036)9.24210072
7* cell-cell recognition (GO:0009988)9.23592210
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.11228320
9cilium movement (GO:0003341)9.02343135
10spermatid development (GO:0007286)8.87489422
11male meiosis (GO:0007140)8.64239146
12regulation of cilium movement (GO:0003352)8.40934245
13* reproduction (GO:0000003)8.16251425
14synaptonemal complex organization (GO:0070193)7.84977795
15synaptonemal complex assembly (GO:0007130)7.59878374
16* single fertilization (GO:0007338)6.82764025
17left/right axis specification (GO:0070986)6.73552432
18DNA methylation involved in gamete generation (GO:0043046)6.57035638
19male meiosis I (GO:0007141)6.19714694
20* fertilization (GO:0009566)5.91054096
21* spermatogenesis (GO:0007283)5.78987146
22* male gamete generation (GO:0048232)5.76985727
23microtubule bundle formation (GO:0001578)5.71754168
24one-carbon compound transport (GO:0019755)5.64359229
25negative regulation of inclusion body assembly (GO:0090084)5.51345616
26* sperm capacitation (GO:0048240)5.49800033
27microtubule depolymerization (GO:0007019)5.33738613
28chromosome organization involved in meiosis (GO:0070192)5.31106271
29* gamete generation (GO:0007276)5.29919776
30meiotic nuclear division (GO:0007126)5.18035661
31germ cell development (GO:0007281)5.11508257
32ventricular system development (GO:0021591)5.09474345
33meiosis I (GO:0007127)5.01983402
34* cellular process involved in reproduction in multicellular organism (GO:0022412)5.00826888
35glomerular epithelial cell development (GO:0072310)4.92815515
36meiotic cell cycle (GO:0051321)4.90292396
37organic cation transport (GO:0015695)4.88835682
38regulation of microtubule-based movement (GO:0060632)4.87450025
39seminiferous tubule development (GO:0072520)4.84847087
40regulation of interleukin-13 production (GO:0032656)4.83853038
41vitamin transmembrane transport (GO:0035461)4.71794395
42primary alcohol catabolic process (GO:0034310)4.66244916
43regulation of interleukin-5 production (GO:0032674)4.52585520
44calcium ion-dependent exocytosis (GO:0017156)4.51620632
45regulation of inclusion body assembly (GO:0090083)4.43203021
46phosphatidylethanolamine biosynthetic process (GO:0006646)4.33205349
47left/right pattern formation (GO:0060972)4.29926092
48microtubule severing (GO:0051013)4.28250217
49* cell recognition (GO:0008037)4.26941101
50protein localization to cilium (GO:0061512)4.24656397
51ethanol metabolic process (GO:0006067)4.23411534
52* multicellular organismal reproductive process (GO:0048609)4.14536426
53gene silencing by RNA (GO:0031047)4.06155111
54phosphatidylethanolamine metabolic process (GO:0046337)4.05165988
55axoneme assembly (GO:0035082)4.05030130
56intraciliary transport (GO:0042073)4.02584654
57monoubiquitinated protein deubiquitination (GO:0035520)3.99227852
58genitalia morphogenesis (GO:0035112)3.96070495
59negative regulation of T cell differentiation in thymus (GO:0033085)3.95934210
60cell projection assembly (GO:0030031)3.95219432
61pyrimidine-containing compound transmembrane transport (GO:0072531)3.93013551
62response to xenobiotic stimulus (GO:0009410)3.87412434
63regulation of centriole replication (GO:0046599)3.80924895
64establishment of apical/basal cell polarity (GO:0035089)3.77565510
65diterpenoid biosynthetic process (GO:0016102)3.69091816
66spermatid nucleus differentiation (GO:0007289)3.67565408
67regulation of female gonad development (GO:2000194)3.58129010
68establishment of monopolar cell polarity (GO:0061162)3.53340477
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.53340477
70cytoplasmic microtubule organization (GO:0031122)3.51833227
71glycerol ether metabolic process (GO:0006662)3.47631333
72microtubule-based movement (GO:0007018)3.47234001
73chaperone-mediated protein complex assembly (GO:0051131)3.45459112
74meiotic cell cycle process (GO:1903046)3.44925540
75protein polyglutamylation (GO:0018095)3.44243393
76tolerance induction (GO:0002507)3.41175295
77lung epithelium development (GO:0060428)3.38247841
78alditol metabolic process (GO:0019400)3.34121740
79* multicellular organismal development (GO:0007275)3.31894386
80centriole assembly (GO:0098534)3.28911773
81ethanol oxidation (GO:0006069)3.25474981
82rRNA methylation (GO:0031167)3.23961985
83cilium organization (GO:0044782)3.23773591
84regulation of meiosis I (GO:0060631)3.22076388
85ether metabolic process (GO:0018904)3.21876276
86negative regulation of organelle assembly (GO:1902116)3.21232815
87establishment of tissue polarity (GO:0007164)3.18369351
88establishment of planar polarity (GO:0001736)3.18369351
89centriole replication (GO:0007099)3.16007132
90synapsis (GO:0007129)3.15457696
91chromosome condensation (GO:0030261)3.12580089
92nucleoside diphosphate phosphorylation (GO:0006165)3.12031276
93cilium assembly (GO:0042384)3.08310955
94regulation of germinal center formation (GO:0002634)3.05876311
95amino-acid betaine transport (GO:0015838)3.05717279
96carnitine transport (GO:0015879)3.05717279
97cilium morphogenesis (GO:0060271)3.02807764
98DNA packaging (GO:0006323)3.02546218
99carnitine transmembrane transport (GO:1902603)3.02521015
100single strand break repair (GO:0000012)2.99674245
101protein refolding (GO:0042026)2.98750787
102negative regulation of humoral immune response (GO:0002921)2.96729002
103polyol catabolic process (GO:0046174)2.96566651
104nuclear pore complex assembly (GO:0051292)2.96429590
105protein targeting to Golgi (GO:0000042)2.94067916
106glycerol metabolic process (GO:0006071)2.93945325
107lactate metabolic process (GO:0006089)2.92557512
108establishment of protein localization to Golgi (GO:0072600)2.91561509
109smoothened signaling pathway (GO:0007224)2.89360404
110gene silencing (GO:0016458)2.88555824
111interferon-gamma secretion (GO:0072643)2.88389693
112regulation of protein polyubiquitination (GO:1902914)2.84869816
113cellular component assembly involved in morphogenesis (GO:0010927)2.83845341
114nucleus organization (GO:0006997)2.82307971
115regulation of cilium assembly (GO:1902017)2.77845261
116negative regulation of immunoglobulin mediated immune response (GO:0002890)2.77355864
117negative regulation of B cell mediated immunity (GO:0002713)2.77355864
118regulation of spindle checkpoint (GO:0090231)2.77219206
119exogenous drug catabolic process (GO:0042738)2.76925948
120peptidyl-glutamic acid modification (GO:0018200)2.76683525
121organelle assembly (GO:0070925)2.76296490
122determination of left/right symmetry (GO:0007368)2.74725332
123retinal rod cell development (GO:0046548)2.73586227
124retinoic acid metabolic process (GO:0042573)2.72391745
125protein K11-linked deubiquitination (GO:0035871)2.71675289
126protein localization to Golgi apparatus (GO:0034067)2.71141439
127GTP biosynthetic process (GO:0006183)2.69543732
128nonmotile primary cilium assembly (GO:0035058)2.68531985
129microtubule-based process (GO:0007017)2.68139529
130retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67511061
131microtubule polymerization or depolymerization (GO:0031109)2.66358309
132sequestering of actin monomers (GO:0042989)2.64706638
133aldehyde catabolic process (GO:0046185)2.63962672
134regulation of interleukin-6 biosynthetic process (GO:0045408)2.63877179
135determination of bilateral symmetry (GO:0009855)2.59651390
136positive regulation of tolerance induction (GO:0002645)2.58099295
137glycolytic process (GO:0006096)2.48295771
138DNA alkylation (GO:0006305)2.48206191
139DNA methylation (GO:0006306)2.48206191
140cilium or flagellum-dependent cell motility (GO:0001539)15.5534375
141fusion of sperm to egg plasma membrane (GO:0007342)12.4286569
142* sperm motility (GO:0030317)11.6277046
143axonemal dynein complex assembly (GO:0070286)10.8037140
144piRNA metabolic process (GO:0034587)10.5521011
145* sperm-egg recognition (GO:0035036)10.3775369
146acrosome assembly (GO:0001675)10.3417263
147epithelial cilium movement (GO:0003351)10.1994275
148* multicellular organism reproduction (GO:0032504)10.0168104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.68830501
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40923312
3EZH2_22144423_ChIP-Seq_EOC_Human4.30777540
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.88799001
5DROSHA_22980978_ChIP-Seq_HELA_Human3.13214424
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63580987
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.60439270
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38323233
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21367410
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20860582
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19952377
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16367675
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.12577639
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07889485
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06350903
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6177728
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97332433
18KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94366155
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89531411
20VDR_22108803_ChIP-Seq_LS180_Human1.83216163
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80783533
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71732796
23STAT1_17558387_ChIP-Seq_HELA_Human1.63199685
24ZNF274_21170338_ChIP-Seq_K562_Hela1.62800768
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.58453686
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.56599786
27FUS_26573619_Chip-Seq_HEK293_Human1.55699271
28AR_21572438_ChIP-Seq_LNCaP_Human1.54622201
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53209405
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52525372
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.50782095
32ETV1_20927104_ChIP-Seq_GIST48_Human1.50143494
33GBX2_23144817_ChIP-Seq_PC3_Human1.49151752
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.48536341
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48037360
36NANOG_20526341_ChIP-Seq_ESCs_Human1.47568982
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47189315
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.46380613
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44735884
40PHF8_20622853_ChIP-Seq_HELA_Human1.44665266
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44373890
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.43760248
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42115971
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41763319
45FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40988552
46CTCF_20526341_ChIP-Seq_ESCs_Human1.40828045
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.40541559
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40075756
49TP53_18474530_ChIP-ChIP_U2OS_Human1.39970006
50AHR_22903824_ChIP-Seq_MCF-7_Human1.39817012
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39706061
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39102175
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37724991
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.36875900
55RBPJ_21746931_ChIP-Seq_IB4_Human1.36780030
56MYC_19829295_ChIP-Seq_ESCs_Human1.35265309
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35100263
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33648372
59SMC4_20622854_ChIP-Seq_HELA_Human1.33445601
60PHF8_20622854_ChIP-Seq_HELA_Human1.32881492
61SMAD4_21799915_ChIP-Seq_A2780_Human1.32563499
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.32471881
63TP63_22573176_ChIP-Seq_HFKS_Human1.31521100
64ERA_21632823_ChIP-Seq_H3396_Human1.31043013
65OCT4_20526341_ChIP-Seq_ESCs_Human1.30902498
66PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30786444
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30567201
68TP63_23658742_ChIP-Seq_EP156T_Human1.30209198
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30150607
70SMRT_27268052_Chip-Seq_Bcells_Human1.29994427
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29425985
72STAT3_23295773_ChIP-Seq_U87_Human1.29141809
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28531427
74TBL1_22424771_ChIP-Seq_293T_Human1.28516266
75NFYB_21822215_ChIP-Seq_K562_Human1.28196739
76CEBPB_22108803_ChIP-Seq_LS180_Human1.27703703
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26484664
78TAF2_19829295_ChIP-Seq_ESCs_Human1.25660077
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24982800
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24336196
81KDM2B_26808549_Chip-Seq_REH_Human1.23897339
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23383262
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21713396
84CTCF_27219007_Chip-Seq_Bcells_Human1.20910214
85SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20559392
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20204107
87P300_27268052_Chip-Seq_Bcells_Human1.20047356
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20005703
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19498967
90P68_20966046_ChIP-Seq_HELA_Human1.19482911
91CBP_20019798_ChIP-Seq_JUKART_Human1.19382729
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19382729
93NFYA_21822215_ChIP-Seq_K562_Human1.19053501
94STAT1_20625510_ChIP-Seq_HELA_Human1.18364581
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18289292
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17973566
97GATA6_21074721_ChIP-Seq_CACO-2_Human1.17317406
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16259194
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.16006807
100AR_25329375_ChIP-Seq_VCAP_Human1.15034015
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14840437
102TCF4_23295773_ChIP-Seq_U87_Human1.14805296
103E2F1_20622854_ChIP-Seq_HELA_Human1.14692612
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14472358
105P53_21459846_ChIP-Seq_SAOS-2_Human1.13399179
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13106924
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.12813848
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12276571
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.12202019
110ER_23166858_ChIP-Seq_MCF-7_Human1.11966137
111RUNX2_22187159_ChIP-Seq_PCA_Human1.11342595
112FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10467789
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.10421195
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09626474
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.09174380
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.09147927
117ERG_20517297_ChIP-Seq_VCAP_Human1.08817655
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08423994
119P300_19829295_ChIP-Seq_ESCs_Human1.07488523
120GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07421005
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07156387
122RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05841402
123RNF2_27304074_Chip-Seq_NSC_Mouse1.05806446
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05740005
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05733107
126CBP_21632823_ChIP-Seq_H3396_Human1.05252843
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.05088743
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04987771
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.04978549
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.04729958
131EZH2_27294783_Chip-Seq_NPCs_Mouse1.04427108
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03872280
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03787226
134ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03735492
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03625754
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03625754
137CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03419795
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03382840
139GF1_26923725_Chip-Seq_HPCs_Mouse1.03158524
140NCOR_22424771_ChIP-Seq_293T_Human1.02854661
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02827283
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02711871
143CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02597834
144OCT4_18555785_Chip-Seq_ESCs_Mouse1.01373330
145BCL6_27268052_Chip-Seq_Bcells_Human1.01348667
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00198565
147SPI1_26923725_Chip-Seq_HPCs_Mouse0.99855093
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99399771
149REST_21632747_ChIP-Seq_MESCs_Mouse0.99379741
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.99067094
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97849639
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97714160
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97068929
154P53_22387025_ChIP-Seq_ESCs_Mouse0.95560067
155P300_18555785_Chip-Seq_ESCs_Mouse0.94722862
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94625082
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.93915840
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93143022
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.91987051
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91930720
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91536716
162CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90914022
163STAT3_18555785_Chip-Seq_ESCs_Mouse0.90283832
164SOX2_21211035_ChIP-Seq_LN229_Human0.89994461
165KLF4_18555785_Chip-Seq_ESCs_Mouse0.89820405
166FOXA1_25329375_ChIP-Seq_VCAP_Human0.89603160
167FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89603160
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89256383
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88365265
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88245148
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88126739
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.87053264
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86630376
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86150151
175PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86134657
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.84939249
177SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84634865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.84271112
2MP0008877_abnormal_DNA_methylation5.56318408
3MP0001929_abnormal_gametogenesis5.45985161
4MP0002653_abnormal_ependyma_morphology4.08446963
5MP0002210_abnormal_sex_determination3.84776561
6MP0001145_abnormal_male_reproductive3.25509768
7MP0002161_abnormal_fertility/fecundity3.17338138
8MP0000653_abnormal_sex_gland2.86542075
9MP0004043_abnormal_pH_regulation2.56502072
10MP0008789_abnormal_olfactory_epithelium2.47269537
11MP0009780_abnormal_chondrocyte_physiolo2.15883845
12MP0000566_synostosis2.06726741
13MP0005394_taste/olfaction_phenotype2.03775040
14MP0005499_abnormal_olfactory_system2.03775040
15MP0005410_abnormal_fertilization14.2594172
16MP0002277_abnormal_respiratory_mucosa1.98289622
17MP0001485_abnormal_pinna_reflex1.85821333
18MP0005395_other_phenotype1.82229785
19MP0002160_abnormal_reproductive_system1.82186663
20MP0002282_abnormal_trachea_morphology1.81742473
21MP0003136_yellow_coat_color1.77011540
22MP0005670_abnormal_white_adipose1.74648812
23MP0005551_abnormal_eye_electrophysiolog1.64648144
24MP0003646_muscle_fatigue1.58167722
25MP0008058_abnormal_DNA_repair1.57376582
26MP0001984_abnormal_olfaction1.56806065
27MP0005623_abnormal_meninges_morphology1.55779493
28MP0010094_abnormal_chromosome_stability1.49954701
29MP0000383_abnormal_hair_follicle1.47404121
30MP0008057_abnormal_DNA_replication1.46589455
31MP0008872_abnormal_physiological_respon1.45929800
32MP0005647_abnormal_sex_gland1.45870323
33MP0002735_abnormal_chemical_nociception1.39032203
34MP0000678_abnormal_parathyroid_gland1.34359102
35MP0001486_abnormal_startle_reflex1.32923581
36MP0001968_abnormal_touch/_nociception1.30064543
37MP0008007_abnormal_cellular_replicative1.29084106
38MP0003656_abnormal_erythrocyte_physiolo1.21005940
39MP0008995_early_reproductive_senescence1.19745071
40MP0001502_abnormal_circadian_rhythm1.18625151
41MP0000026_abnormal_inner_ear1.17391405
42MP0010678_abnormal_skin_adnexa1.16794146
43MP0009046_muscle_twitch1.14929187
44MP0001348_abnormal_lacrimal_gland1.13748476
45MP0002249_abnormal_larynx_morphology1.12948067
46MP0003111_abnormal_nucleus_morphology1.11539207
47MP0003195_calcinosis1.09626420
48MP0001963_abnormal_hearing_physiology1.08966350
49MP0002168_other_aberrant_phenotype1.07769521
50MP0001765_abnormal_ion_homeostasis1.05894466
51MP0002139_abnormal_hepatobiliary_system1.05060624
52MP0005389_reproductive_system_phenotype1.03601081
53MP0003786_premature_aging1.02703461
54MP0001664_abnormal_digestion1.02028111
55MP0005220_abnormal_exocrine_pancreas1.01078892
56MP0003011_delayed_dark_adaptation0.99592399
57MP0002638_abnormal_pupillary_reflex0.93089820
58MP0002736_abnormal_nociception_after0.92360519
59MP0002734_abnormal_mechanical_nocicepti0.92049396
60MP0009643_abnormal_urine_homeostasis0.91231166
61MP0000569_abnormal_digit_pigmentation0.89068887
62MP0001986_abnormal_taste_sensitivity0.88651081
63MP0002132_abnormal_respiratory_system0.87890135
64MP0004233_abnormal_muscle_weight0.86229883
65MP0009745_abnormal_behavioral_response0.85404241
66MP0003183_abnormal_peptide_metabolism0.85374641
67MP0010030_abnormal_orbit_morphology0.84681399
68MP0002136_abnormal_kidney_physiology0.80642351
69MP0005365_abnormal_bile_salt0.78353032
70MP0005423_abnormal_somatic_nervous0.77600254
71MP0002138_abnormal_hepatobiliary_system0.76084776
72MP0002557_abnormal_social/conspecific_i0.75394566
73MP0002229_neurodegeneration0.75348439
74MP0004742_abnormal_vestibular_system0.74503935
75MP0000358_abnormal_cell_content/0.74267232
76MP0001666_abnormal_nutrient_absorption0.73893327
77MP0000631_abnormal_neuroendocrine_gland0.73537379
78MP0002272_abnormal_nervous_system0.73132484
79MP0004134_abnormal_chest_morphology0.72687612
80MP0005310_abnormal_salivary_gland0.71961857
81MP0001970_abnormal_pain_threshold0.70635551
82MP0003693_abnormal_embryo_hatching0.70177940
83MP0000015_abnormal_ear_pigmentation0.69301176
84MP0001119_abnormal_female_reproductive0.69265146
85MP0001501_abnormal_sleep_pattern0.68175836
86MP0004019_abnormal_vitamin_homeostasis0.65407773
87MP0001944_abnormal_pancreas_morphology0.65272115
88MP0005408_hypopigmentation0.64385254
89MP0003950_abnormal_plasma_membrane0.62805689
90MP0003119_abnormal_digestive_system0.62433019
91MP0003699_abnormal_female_reproductive0.61377552
92MP0005636_abnormal_mineral_homeostasis0.60774506
93MP0001905_abnormal_dopamine_level0.60269951
94MP0002572_abnormal_emotion/affect_behav0.58224960
95MP0005646_abnormal_pituitary_gland0.57777926
96MP0002234_abnormal_pharynx_morphology0.56590278
97MP0002909_abnormal_adrenal_gland0.56528679
98MP0005451_abnormal_body_composition0.56450165
99MP0002928_abnormal_bile_duct0.56207733
100MP0000681_abnormal_thyroid_gland0.55842039
101MP0008875_abnormal_xenobiotic_pharmacok0.55791472
102MP0000470_abnormal_stomach_morphology0.54754532
103MP0001756_abnormal_urination0.54717294
104MP0002233_abnormal_nose_morphology0.52515419
105MP0003077_abnormal_cell_cycle0.52507084
106MP0001346_abnormal_lacrimal_gland0.52284118
107MP0003115_abnormal_respiratory_system0.51357265
108MP0001324_abnormal_eye_pigmentation0.50140632
109MP0003878_abnormal_ear_physiology0.49313257
110MP0005377_hearing/vestibular/ear_phenot0.49313257
111MP0005085_abnormal_gallbladder_physiolo0.48591089
112MP0002102_abnormal_ear_morphology0.48375544
113MP0005083_abnormal_biliary_tract0.43715802
114MP0002822_catalepsy0.40472707
115MP0003252_abnormal_bile_duct0.40320150
116MP0001730_embryonic_growth_arrest0.40088102
117MP0001545_abnormal_hematopoietic_system0.38982526
118MP0005397_hematopoietic_system_phenotyp0.38982526
119MP0010307_abnormal_tumor_latency0.37972142
120MP0004133_heterotaxia0.37503194
121MP0003718_maternal_effect0.37371024
122MP0001851_eye_inflammation0.36795617
123MP0000534_abnormal_ureter_morphology0.36493863
124MP0003936_abnormal_reproductive_system0.35729190
125MP0004808_abnormal_hematopoietic_stem0.34189355
126MP0000313_abnormal_cell_death0.33823769
127MP0009697_abnormal_copulation0.33015908
128MP0002084_abnormal_developmental_patter0.30663937
129MP0003879_abnormal_hair_cell0.29847192
130MP0002163_abnormal_gland_morphology0.29247015
131MP0004264_abnormal_extraembryonic_tissu0.28791586
132MP0000427_abnormal_hair_cycle0.28227524
133MP0001293_anophthalmia0.26495536
134MP0001764_abnormal_homeostasis0.26391568
135MP0010329_abnormal_lipoprotein_level0.26279015
136MP0005360_urolithiasis0.25728153
137MP0001270_distended_abdomen0.24797682
138MP0002405_respiratory_system_inflammati0.24506226
139MP0001873_stomach_inflammation0.24067388
140MP0006036_abnormal_mitochondrial_physio0.23962034
141MP0003315_abnormal_perineum_morphology0.23829532
142MP0001672_abnormal_embryogenesis/_devel0.23712306
143MP0005380_embryogenesis_phenotype0.23712306
144MP0001697_abnormal_embryo_size0.23380470
145MP0002876_abnormal_thyroid_physiology0.22945740
146MP0005253_abnormal_eye_physiology0.22942430
147MP0001919_abnormal_reproductive_system0.22735550
148MP0005076_abnormal_cell_differentiation0.22425255
149MP0006082_CNS_inflammation0.21866570
150MP0002269_muscular_atrophy0.21800659
151MP0005391_vision/eye_phenotype0.21450344
152MP0005319_abnormal_enzyme/_coenzyme0.21260022
153MP0005666_abnormal_adipose_tissue0.19586794
154MP0003861_abnormal_nervous_system0.19449693
155MP0000639_abnormal_adrenal_gland0.19354877
156MP0001727_abnormal_embryo_implantation0.19077688

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.30695747
2Abnormal respiratory motile cilium morphology (HP:0005938)8.72640104
3Abnormal respiratory epithelium morphology (HP:0012253)8.72640104
4Rhinitis (HP:0012384)7.99807227
5Abnormal ciliary motility (HP:0012262)7.65451181
6Chronic bronchitis (HP:0004469)7.08251344
7Infertility (HP:0000789)6.29386145
8Nasal polyposis (HP:0100582)6.26687735
9Abnormality of the nasal mucosa (HP:0000433)5.03377523
10Bronchiectasis (HP:0002110)4.69034131
11Bronchitis (HP:0012387)4.35350064
12Nephronophthisis (HP:0000090)4.07664437
13Chronic hepatic failure (HP:0100626)4.06709791
14Occipital encephalocele (HP:0002085)3.77839553
15Male infertility (HP:0003251)3.55421100
16Recurrent sinusitis (HP:0011108)3.37688217
17Gonadotropin excess (HP:0000837)3.36939380
18Recurrent otitis media (HP:0000403)3.36209382
19Pancreatic cysts (HP:0001737)3.28424576
20Abnormality of the renal medulla (HP:0100957)3.26775216
21Abnormality of the lower motor neuron (HP:0002366)3.25568094
22Tubulointerstitial nephritis (HP:0001970)3.09614630
23Abnormal spermatogenesis (HP:0008669)2.96724800
24Fibular hypoplasia (HP:0003038)2.92874153
25Medial flaring of the eyebrow (HP:0010747)2.91569269
26Impulsivity (HP:0100710)2.86251838
27Amyotrophic lateral sclerosis (HP:0007354)2.60059723
28Tubulointerstitial abnormality (HP:0001969)2.57721742
29Recurrent bronchitis (HP:0002837)2.53415878
30Atelectasis (HP:0100750)2.46455939
31Hyperactive renin-angiotensin system (HP:0000841)2.43620161
32Tubular atrophy (HP:0000092)2.42968502
33Supernumerary spleens (HP:0009799)2.39228038
34Chronic otitis media (HP:0000389)2.38211156
35Molar tooth sign on MRI (HP:0002419)2.36954641
36Abnormality of midbrain morphology (HP:0002418)2.36954641
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29261859
38Azoospermia (HP:0000027)2.25754812
39Postaxial foot polydactyly (HP:0001830)2.24838237
40Upper motor neuron abnormality (HP:0002127)2.18083233
41Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16828631
42Absent epiphyses (HP:0010577)2.16828631
43Anencephaly (HP:0002323)2.13984997
44Hyperkalemia (HP:0002153)2.13525377
45Tubulointerstitial fibrosis (HP:0005576)2.09305616
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1402288
47Absent/shortened dynein arms (HP:0200106)11.8649989
48Dynein arm defect of respiratory motile cilia (HP:0012255)11.8649989
49Short ribs (HP:0000773)1.99833748
50Abnormality of macular pigmentation (HP:0008002)1.99595234
51Abnormality of the renal cortex (HP:0011035)1.98061007
52Decreased central vision (HP:0007663)1.95283490
53Male pseudohermaphroditism (HP:0000037)1.94074215
54Absent frontal sinuses (HP:0002688)1.93769531
55Cone-rod dystrophy (HP:0000548)1.92267825
56Congenital hepatic fibrosis (HP:0002612)1.90343328
57Gait imbalance (HP:0002141)1.88087151
58Pancreatic fibrosis (HP:0100732)1.88012094
59Renal dysplasia (HP:0000110)1.87165790
60Aplasia/Hypoplasia of the fibula (HP:0006492)1.86967320
61Congenital primary aphakia (HP:0007707)1.86643736
62Sclerocornea (HP:0000647)1.85959891
63Attenuation of retinal blood vessels (HP:0007843)1.85051126
64Short femoral neck (HP:0100864)1.80721788
65Decreased circulating renin level (HP:0003351)1.77062070
66Abnormality of permanent molar morphology (HP:0011071)1.76494132
67Abnormality of the dental root (HP:0006486)1.76494132
68Taurodontia (HP:0000679)1.76494132
69Heterotopia (HP:0002282)1.76182834
70Spastic tetraparesis (HP:0001285)1.75022608
71Impaired proprioception (HP:0010831)1.74906420
72Postaxial hand polydactyly (HP:0001162)1.73852040
73Broad distal phalanx of finger (HP:0009836)1.73769019
74Stage 5 chronic kidney disease (HP:0003774)1.71113934
75Severe visual impairment (HP:0001141)1.69893575
7611 pairs of ribs (HP:0000878)1.68954529
77Cystic liver disease (HP:0006706)1.67674365
78Degeneration of anterior horn cells (HP:0002398)1.65824303
79Abnormality of the anterior horn cell (HP:0006802)1.65824303
80Bony spicule pigmentary retinopathy (HP:0007737)1.65813207
81Polydipsia (HP:0001959)1.65745155
82Abnormal drinking behavior (HP:0030082)1.65745155
83Chronic sinusitis (HP:0011109)1.65526233
84Nephrogenic diabetes insipidus (HP:0009806)1.64377256
85Microglossia (HP:0000171)1.62837479
86Abnormality of molar morphology (HP:0011070)1.60752122
87Abnormality of molar (HP:0011077)1.60752122
88Bile duct proliferation (HP:0001408)1.60107432
89Abnormal biliary tract physiology (HP:0012439)1.60107432
90Abnormality of the hepatic vasculature (HP:0006707)1.57659914
91Abnormality of dentin (HP:0010299)1.57493971
92Abnormality of the dental pulp (HP:0006479)1.56815535
93Irregular epiphyses (HP:0010582)1.56209851
94Short thorax (HP:0010306)1.54828920
95Furrowed tongue (HP:0000221)1.54423133
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54344894
97Oculomotor apraxia (HP:0000657)1.52400700
98Flattened epiphyses (HP:0003071)1.52217714
99Abnormal gallbladder physiology (HP:0012438)1.51485879
100Cholecystitis (HP:0001082)1.51485879
101Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.49198428
102Preaxial hand polydactyly (HP:0001177)1.47411290
103True hermaphroditism (HP:0010459)1.47408517
104Fetal akinesia sequence (HP:0001989)1.46053757
105Renal salt wasting (HP:0000127)1.45388972
106Abnormal rod and cone electroretinograms (HP:0008323)1.44604658
107Poor coordination (HP:0002370)1.43154830
108Polyuria (HP:0000103)1.42723355
109Portal hypertension (HP:0001409)1.41671094
110Facial cleft (HP:0002006)1.40677859
111Nephropathy (HP:0000112)1.39283510
112Abnormality of renal excretion (HP:0011036)1.38675216
113Median cleft lip (HP:0000161)1.37480855
114J-shaped sella turcica (HP:0002680)1.36984270
115Intellectual disability, moderate (HP:0002342)1.34016447
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32985985
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.32674059
118Type II lissencephaly (HP:0007260)1.32550378
119Breast carcinoma (HP:0003002)1.31239945
120Abnormal urine output (HP:0012590)1.30390321
121Hyperaldosteronism (HP:0000859)1.30259131
122Aplasia/Hypoplasia of the lens (HP:0008063)1.28784829
123Abnormality of ocular smooth pursuit (HP:0000617)1.28615262
124Hypophosphatemic rickets (HP:0004912)1.27708012
125Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.26616547
126Abnormality of chloride homeostasis (HP:0011422)1.26501257
127Hyponatremia (HP:0002902)1.24925261
128Asplenia (HP:0001746)1.24912250
129Abnormality of renin-angiotensin system (HP:0000847)1.24278279
130Genital tract atresia (HP:0001827)1.24222999
131Aplasia/Hypoplasia of the spleen (HP:0010451)1.23827719
132Short nail (HP:0001799)1.22136984
133Disproportionate short-trunk short stature (HP:0003521)1.22114358
134Abnormality of the epiphysis of the femoral head (HP:0010574)1.20881901
135Sloping forehead (HP:0000340)1.19922680
136Bell-shaped thorax (HP:0001591)1.19233318
137Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.18296477
138Retinitis pigmentosa (HP:0000510)1.16595703
139Aplasia of the musculature (HP:0100854)1.15008072
140Pendular nystagmus (HP:0012043)1.13965543
141Popliteal pterygium (HP:0009756)1.09158832
142Absent speech (HP:0001344)1.06684649
143Abdominal situs inversus (HP:0003363)1.06608349
144Abnormality of abdominal situs (HP:0011620)1.06608349
145Abnormality of the labia majora (HP:0012881)1.06357238
146Amelogenesis imperfecta (HP:0000705)1.04820607
147Abnormality of dental color (HP:0011073)1.04371638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.89787489
2PDK38.89787489
3PDK26.01455368
4INSRR4.94208242
5TESK14.58301977
6MST43.66230957
7PRKD33.65739202
8ICK2.85128051
9EPHA22.70395959
10STK392.33366580
11PNCK2.16192704
12NEK22.15426887
13WNK42.14619062
14MAP4K22.04029461
15PTK2B1.85090899
16TLK11.74149338
17ADRBK21.68347626
18MAP3K21.63572622
19FRK1.37424627
20MAPK151.36288526
21STK381.34797429
22NME11.33263043
23BRD41.29279216
24CCNB11.26156543
25STK31.15987439
26AKT31.14244755
27DYRK31.08692174
28CDK191.07390690
29ZAK1.02421513
30WEE11.01310792
31PLK20.96034310
32PLK40.91777306
33ACVR1B0.91027711
34TTK0.89954316
35DYRK1B0.89799089
36WNK10.89019465
37PDK10.88545034
38MAP3K70.87385463
39PASK0.87175781
40GRK10.86979527
41TESK20.86655107
42STK38L0.83906214
43MAP3K90.79160273
44PINK10.77097719
45ADRBK10.72325672
46CDC70.72209527
47BMPR1B0.69961838
48MET0.69490219
49ATR0.68123056
50PRKCI0.66728068
51MAP2K60.65894151
52PIK3CG0.61842693
53IRAK10.61261524
54CHEK20.61186296
55CHEK10.54230731
56BRAF0.50011264
57PLK10.47666453
58MAP3K130.47505275
59IRAK20.47308436
60EEF2K0.44589780
61RPS6KA20.44194968
62MUSK0.41655029
63ATM0.40188076
64TRPM70.39960851
65BUB10.39914438
66MARK20.39817216
67NEK60.37944880
68PRKACA0.37919057
69RPS6KA50.37879164
70SGK10.37870598
71CAMK1G0.36898380
72MTOR0.35044633
73PBK0.33679350
74TYRO30.33650418
75YES10.32958266
76PDPK10.32894447
77PKN10.31037339
78LMTK20.30922746
79MAP2K10.30495135
80PRKAA20.30151625
81ROCK10.30000610
82LRRK20.29709037
83STK110.29679761
84PRKCA0.29612820
85STK160.29305416
86PAK10.29096183
87EPHA40.28676330
88LATS10.27869648
89CAMK2A0.27358878
90PRKCD0.26595568
91RPS6KB10.25664562
92CAMK10.25463876
93MAPKAPK30.24639135
94PRKAA10.24447296
95CDK80.23486010
96AKT20.23117990
97ERBB20.22693233
98STK100.22372225
99MST1R0.21562523
100PRKCE0.20947861
101CDK70.20585808
102TXK0.20565380
103MAP3K80.20218089
104CDK90.20146890
105PRKCG0.19827670
106RPS6KA60.18316887
107MAP3K110.17928407
108CDK120.16411420
109MAP2K70.16010643
110CDK30.15975144
111PAK20.15971867
112RPS6KA40.12999065
113ERN10.12807616
114AURKA0.11091689
115BRSK20.10644640
116EIF2AK20.10497284
117MAP3K40.10395556
118ZAP700.08725664
119PIM20.08437898
120CDK10.08389941
121CDK20.08152518
122BRSK10.07982403
123PRKCQ0.06987769
124AURKB0.06629013
125CSNK2A10.05217316
126PRKCZ0.04451520
127PRKG20.04278292
128RPS6KB20.03876739
129PAK40.03671298
130CAMKK10.03665435
131ERBB40.03543804
132GSK3B0.03500340
133ABL10.02610866
134PRKACG0.02077521
135DDR20.02041420
136MAP3K30.01868887
137FER0.01810928
138BCKDK0.01750244
139PRKG10.01245507
140CSK0.01191743
141MAPK8-0.0381133
142ARAF-0.0380282
143PTK6-0.0347921
144PRKDC-0.0284846
145MAP3K5-0.0273328
146RIPK4-0.0261130
147PAK6-0.0239694
148RPS6KA1-0.0224132
149OXSR1-0.0220160
150NTRK2-0.0206971
151WNK3-0.0129632
152STK24-0.0111451

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.09299190
2Pyruvate metabolism_Homo sapiens_hsa006204.32172512
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.80061131
4Basal transcription factors_Homo sapiens_hsa030223.21335341
5Propanoate metabolism_Homo sapiens_hsa006402.88126738
6Tyrosine metabolism_Homo sapiens_hsa003502.63741347
7Caffeine metabolism_Homo sapiens_hsa002322.62142278
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61277467
9Fanconi anemia pathway_Homo sapiens_hsa034602.60699104
10Fatty acid biosynthesis_Homo sapiens_hsa000612.59362032
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39356488
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.35723731
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29809239
14Glucagon signaling pathway_Homo sapiens_hsa049222.29692908
15Linoleic acid metabolism_Homo sapiens_hsa005912.26476602
16Selenocompound metabolism_Homo sapiens_hsa004502.22402892
17Dorso-ventral axis formation_Homo sapiens_hsa043202.22028582
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21456636
19Olfactory transduction_Homo sapiens_hsa047402.20972429
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.16758680
21Pentose phosphate pathway_Homo sapiens_hsa000302.12647069
22beta-Alanine metabolism_Homo sapiens_hsa004101.92848710
23Butanoate metabolism_Homo sapiens_hsa006501.79187082
24Oocyte meiosis_Homo sapiens_hsa041141.77758000
25Glycerolipid metabolism_Homo sapiens_hsa005611.73272892
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.71071361
27RNA transport_Homo sapiens_hsa030131.69272656
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57053583
29Phototransduction_Homo sapiens_hsa047441.55592721
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53598262
31mRNA surveillance pathway_Homo sapiens_hsa030151.51430471
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48364049
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.47572852
34Nicotine addiction_Homo sapiens_hsa050331.45940833
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45125481
36Fructose and mannose metabolism_Homo sapiens_hsa000511.43258999
37Carbon metabolism_Homo sapiens_hsa012001.42340210
38PPAR signaling pathway_Homo sapiens_hsa033201.41060032
39Antigen processing and presentation_Homo sapiens_hsa046121.38317493
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37263680
41Huntingtons disease_Homo sapiens_hsa050161.30639715
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25704769
43Nitrogen metabolism_Homo sapiens_hsa009101.24266654
44Salivary secretion_Homo sapiens_hsa049701.22191980
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19259901
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19138022
47Ether lipid metabolism_Homo sapiens_hsa005651.15101200
48Purine metabolism_Homo sapiens_hsa002301.14830049
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13743562
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13250920
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10071237
52Amphetamine addiction_Homo sapiens_hsa050311.09617569
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07880442
54Fatty acid degradation_Homo sapiens_hsa000711.06509233
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05228023
56Chemical carcinogenesis_Homo sapiens_hsa052041.04655058
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01598546
58Circadian rhythm_Homo sapiens_hsa047101.00915360
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00815259
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94260753
61ABC transporters_Homo sapiens_hsa020100.93883938
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92623751
63Fat digestion and absorption_Homo sapiens_hsa049750.88200128
64Homologous recombination_Homo sapiens_hsa034400.87212690
65Fatty acid metabolism_Homo sapiens_hsa012120.87051485
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.86479882
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85815988
68Calcium signaling pathway_Homo sapiens_hsa040200.79744569
69Tryptophan metabolism_Homo sapiens_hsa003800.78697883
70Starch and sucrose metabolism_Homo sapiens_hsa005000.78241976
71Pyrimidine metabolism_Homo sapiens_hsa002400.77208459
72Ovarian steroidogenesis_Homo sapiens_hsa049130.76255190
73Serotonergic synapse_Homo sapiens_hsa047260.75620000
74Legionellosis_Homo sapiens_hsa051340.75052482
75Collecting duct acid secretion_Homo sapiens_hsa049660.72684282
76Renin-angiotensin system_Homo sapiens_hsa046140.68892035
77RNA degradation_Homo sapiens_hsa030180.68772917
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68104779
79p53 signaling pathway_Homo sapiens_hsa041150.66943878
80cAMP signaling pathway_Homo sapiens_hsa040240.64063748
81Tight junction_Homo sapiens_hsa045300.58610542
82Glutathione metabolism_Homo sapiens_hsa004800.58152502
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57288462
84Cell cycle_Homo sapiens_hsa041100.56886055
85Cocaine addiction_Homo sapiens_hsa050300.56200974
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56017440
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54705042
88Metabolic pathways_Homo sapiens_hsa011000.54347745
89Retinol metabolism_Homo sapiens_hsa008300.54298697
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52236435
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.51590451
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.51367828
93Arginine and proline metabolism_Homo sapiens_hsa003300.48329639
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48202427
95Mineral absorption_Homo sapiens_hsa049780.48119139
96VEGF signaling pathway_Homo sapiens_hsa043700.47270763
97N-Glycan biosynthesis_Homo sapiens_hsa005100.46701421
98Renin secretion_Homo sapiens_hsa049240.44928787
99Nucleotide excision repair_Homo sapiens_hsa034200.42824507
100AMPK signaling pathway_Homo sapiens_hsa041520.42767488
101Alcoholism_Homo sapiens_hsa050340.41934923
102Arachidonic acid metabolism_Homo sapiens_hsa005900.41413146
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.39970911
104Synaptic vesicle cycle_Homo sapiens_hsa047210.39875391
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39429134
106Phenylalanine metabolism_Homo sapiens_hsa003600.36705960
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36181089
108Morphine addiction_Homo sapiens_hsa050320.33916110
109Basal cell carcinoma_Homo sapiens_hsa052170.33517872
110Sphingolipid metabolism_Homo sapiens_hsa006000.33150625
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32376880
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32011245
113Insulin secretion_Homo sapiens_hsa049110.31935879
114Systemic lupus erythematosus_Homo sapiens_hsa053220.31547878
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30928817
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29625003
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28034731
118Circadian entrainment_Homo sapiens_hsa047130.27835034
119Complement and coagulation cascades_Homo sapiens_hsa046100.27284414
120Protein digestion and absorption_Homo sapiens_hsa049740.26882479
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.26373396
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26310107
123Regulation of autophagy_Homo sapiens_hsa041400.25872911
124Cardiac muscle contraction_Homo sapiens_hsa042600.25524158
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25467630
126Taste transduction_Homo sapiens_hsa047420.25045561
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24896194
128Long-term potentiation_Homo sapiens_hsa047200.24889869
129Pancreatic secretion_Homo sapiens_hsa049720.24143931
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24013689
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23023233
132Bile secretion_Homo sapiens_hsa049760.22940239
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22472791
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22452855
135Sulfur relay system_Homo sapiens_hsa041220.22226587
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.21047053
137Vitamin digestion and absorption_Homo sapiens_hsa049770.20942842
138Endocytosis_Homo sapiens_hsa041440.20827133
139Choline metabolism in cancer_Homo sapiens_hsa052310.19952950
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19760760
141Spliceosome_Homo sapiens_hsa030400.18759169
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16319237
143Glutamatergic synapse_Homo sapiens_hsa047240.16149337
144Hedgehog signaling pathway_Homo sapiens_hsa043400.15650760
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14637858
146Gastric acid secretion_Homo sapiens_hsa049710.14338662
147Histidine metabolism_Homo sapiens_hsa003400.14133691
148Hematopoietic cell lineage_Homo sapiens_hsa046400.13754227
149Peroxisome_Homo sapiens_hsa041460.13746129
150RNA polymerase_Homo sapiens_hsa030200.11872185

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