CAV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.99488272
2actin-myosin filament sliding (GO:0033275)9.99488272
3sarcomere organization (GO:0045214)9.65257273
4cardiac myofibril assembly (GO:0055003)8.82244554
5myofibril assembly (GO:0030239)8.35627458
6actin-mediated cell contraction (GO:0070252)8.29703636
7skeletal muscle fiber development (GO:0048741)7.39940848
8cardiac muscle contraction (GO:0060048)6.98736586
9* negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.93720695
10muscle atrophy (GO:0014889)6.69200315
11myotube cell development (GO:0014904)6.60803020
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.58283242
13muscle cell fate commitment (GO:0042693)6.56931747
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.51230322
15striated muscle contraction (GO:0006941)6.41205094
16actomyosin structure organization (GO:0031032)6.29641367
17* negative regulation of potassium ion transmembrane transport (GO:1901380)6.27145495
18actin filament-based movement (GO:0030048)6.21559860
19sarcoplasmic reticulum calcium ion transport (GO:0070296)6.18412793
20regulation of relaxation of muscle (GO:1901077)6.14532974
21tricarboxylic acid cycle (GO:0006099)6.11804705
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.10444943
23skeletal muscle tissue regeneration (GO:0043403)6.06057117
24* cardiac muscle cell development (GO:0055013)6.00784481
25skeletal muscle tissue development (GO:0007519)5.88457180
26skeletal muscle contraction (GO:0003009)5.83747856
27positive regulation of myoblast differentiation (GO:0045663)5.78503961
28* plasma membrane repair (GO:0001778)5.78247610
29regulation of actin filament-based movement (GO:1903115)5.78015702
30cardiac muscle tissue morphogenesis (GO:0055008)5.73005765
31adult heart development (GO:0007512)5.67404119
32* regulation of skeletal muscle contraction (GO:0014819)5.66580154
33* cardiac cell development (GO:0055006)5.63916620
34cardiac muscle hypertrophy (GO:0003300)5.45703849
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.39853665
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.36029760
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.30895094
38heart process (GO:0003015)5.24390899
39heart contraction (GO:0060047)5.24390899
40muscle tissue morphogenesis (GO:0060415)5.23319139
41striated muscle hypertrophy (GO:0014897)5.23026347
42regulation of cell communication by electrical coupling (GO:0010649)5.21559834
43* positive regulation of myotube differentiation (GO:0010831)5.19582110
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.17247195
45carnitine shuttle (GO:0006853)5.04979634
46response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.01235794
47bundle of His cell to Purkinje myocyte communication (GO:0086069)4.85558355
48myotube differentiation (GO:0014902)4.84630284
49* regulation of striated muscle contraction (GO:0006942)4.83486514
50* muscle organ development (GO:0007517)4.80543420
51* muscle structure development (GO:0061061)4.75111593
52* ventricular cardiac muscle cell action potential (GO:0086005)4.71968705
53* regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.71137121
54regulation of acyl-CoA biosynthetic process (GO:0050812)4.70987424
55muscle hypertrophy (GO:0014896)4.63891786
56regulation of the force of heart contraction (GO:0002026)4.59150928
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55140293
58* muscle cell cellular homeostasis (GO:0046716)4.54099914
59muscle contraction (GO:0006936)4.39433624
60muscle adaptation (GO:0043500)4.31412414
61fatty acid transmembrane transport (GO:1902001)4.31049439
62regulation of coenzyme metabolic process (GO:0051196)4.30111533
63regulation of cofactor metabolic process (GO:0051193)4.30111533
64energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27953517
65ATP synthesis coupled proton transport (GO:0015986)4.27953517
66response to inactivity (GO:0014854)4.18897754
67cell communication involved in cardiac conduction (GO:0086065)4.15883541
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.15769128
69regulation of myoblast differentiation (GO:0045661)4.12706951
70* regulation of membrane repolarization (GO:0060306)4.12584518
71striated muscle tissue development (GO:0014706)4.09005663
72* heart trabecula formation (GO:0060347)4.08712715
73ribonucleoprotein complex disassembly (GO:0032988)4.07256648
74negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.07191061
75muscle system process (GO:0003012)4.06142230
76regulation of ATPase activity (GO:0043462)4.02021455
77regulation of ATP catabolic process (GO:1903289)4.02021455
78regulation of skeletal muscle cell differentiation (GO:2001014)4.01520857
79cardiac muscle adaptation (GO:0014887)4.00495547
80cardiac muscle hypertrophy in response to stress (GO:0014898)4.00495547
81muscle hypertrophy in response to stress (GO:0003299)4.00495547
82creatine metabolic process (GO:0006600)3.98425272
83* striated muscle cell development (GO:0055002)3.98395491
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97572048
85respiratory electron transport chain (GO:0022904)3.93661332
86positive regulation of skeletal muscle tissue development (GO:0048643)3.92592682
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.92001058
88striated muscle adaptation (GO:0014888)3.89746118
89oxidative phosphorylation (GO:0006119)3.85932875
90regulation of alkaline phosphatase activity (GO:0010692)3.85387616
91electron transport chain (GO:0022900)3.82571046
92positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.81526871
93negative regulation of striated muscle cell apoptotic process (GO:0010664)3.81387859
94* myoblast fusion (GO:0007520)3.71802611
95skeletal muscle adaptation (GO:0043501)3.71792644
96carnitine transmembrane transport (GO:1902603)3.70468168
97regulation of cardioblast differentiation (GO:0051890)3.69313059
98activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.68549823
99* regulation of heart rate (GO:0002027)3.67774991
100glucan biosynthetic process (GO:0009250)3.67387791
101glycogen biosynthetic process (GO:0005978)3.67387791
102response to activity (GO:0014823)3.66497476
103muscle fiber development (GO:0048747)3.64548362
104NADH metabolic process (GO:0006734)3.62459038
105glycogen catabolic process (GO:0005980)3.60856294
106muscle tissue development (GO:0060537)3.59221469
107cell communication by electrical coupling (GO:0010644)3.58034254
108regulation of cardiac muscle cell contraction (GO:0086004)3.57226403
109cytidine metabolic process (GO:0046087)3.57198203
110cytidine catabolic process (GO:0006216)3.57198203
111cytidine deamination (GO:0009972)3.57198203
112* regulation of sarcomere organization (GO:0060297)3.54827396
113pyrimidine ribonucleoside catabolic process (GO:0046133)3.49698750
114ventricular cardiac muscle cell development (GO:0055015)3.48224894
115regulation of sulfur metabolic process (GO:0042762)3.47601751
116* regulation of cardiac muscle contraction (GO:0055117)3.47427051
117* regulation of heart contraction (GO:0008016)3.46413715
1182-oxoglutarate metabolic process (GO:0006103)3.44541701
119* regulation of muscle contraction (GO:0006937)3.43425863
120* muscle cell development (GO:0055001)3.42808003
121* regulation of muscle system process (GO:0090257)3.40054552
122response to muscle activity (GO:0014850)3.40027148
123negative regulation of calcium ion transmembrane transport (GO:1903170)3.38459542
124negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.38459542
125glucan catabolic process (GO:0009251)3.37282132
126regulation of skeletal muscle fiber development (GO:0048742)3.36264910
127* cardiac muscle cell action potential involved in contraction (GO:0086002)3.36183722
128carnitine transport (GO:0015879)3.36154007
129amino-acid betaine transport (GO:0015838)3.36154007
130striated muscle atrophy (GO:0014891)3.35393234
131* cardiac muscle cell action potential (GO:0086001)3.34285161
132positive regulation of cation channel activity (GO:2001259)3.34033048
133neuromuscular synaptic transmission (GO:0007274)3.33947811
134mitochondrial genome maintenance (GO:0000002)3.18894066
135* syncytium formation by plasma membrane fusion (GO:0000768)3.18598783
136* regulation of myotube differentiation (GO:0010830)3.15710396
137* regulation of calcium ion transmembrane transporter activity (GO:1901019)3.13440362
138* regulation of calcium ion transmembrane transport (GO:1903169)3.13440362
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.11228184
140cellular polysaccharide catabolic process (GO:0044247)3.10964650
141response to parathyroid hormone (GO:0071107)3.10366033
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95827525
143organelle disassembly (GO:1903008)2.95736386
144muscle organ morphogenesis (GO:0048644)2.92190103
145skeletal muscle cell differentiation (GO:0035914)2.90612403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.32613243
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.75630555
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.35789256
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.10872156
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.10872156
6VDR_22108803_ChIP-Seq_LS180_Human3.95312636
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.76459687
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.58309921
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.51713304
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.46061317
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.32311890
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08589944
13ZNF263_19887448_ChIP-Seq_K562_Human3.02652401
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69440688
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.64639070
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55325327
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55325327
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55325327
19GATA4_21415370_ChIP-Seq_HL-1_Mouse2.39819921
20IGF1R_20145208_ChIP-Seq_DFB_Human2.31937890
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25542430
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.11327080
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09118877
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07776036
25NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.90718506
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86938226
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86110934
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83292542
29CLOCK_20551151_ChIP-Seq_293T_Human1.81106490
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.79120593
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.73120524
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68543256
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63302491
34EZH2_22144423_ChIP-Seq_EOC_Human1.58498912
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56848095
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54603647
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.49104495
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41207171
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38072858
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36753068
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34651910
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33363488
43CTCF_27219007_Chip-Seq_Bcells_Human1.31048854
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30313818
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30036851
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25509494
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25391078
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25007818
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24640148
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22355039
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20137122
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18815175
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18125507
54KDM2B_26808549_Chip-Seq_DND41_Human1.17387224
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.17232320
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.16416270
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16372283
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15428640
59RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14156090
60TP63_22573176_ChIP-Seq_HFKS_Human1.14062421
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12663073
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12161190
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.09001727
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.08890271
65LXR_22292898_ChIP-Seq_THP-1_Human1.08850913
66SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08333155
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08054075
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.07697134
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07079996
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06500625
71RACK7_27058665_Chip-Seq_MCF-7_Human1.06031604
72DROSHA_22980978_ChIP-Seq_HELA_Human1.05355391
73ATF3_27146783_Chip-Seq_COLON_Human1.04409771
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04236085
75* CJUN_26792858_Chip-Seq_BT549_Human1.02878960
76GATA1_19941826_ChIP-Seq_K562_Human1.01994904
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01832032
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.01650716
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01619952
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.99065143
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98183847
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97318721
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97085600
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96964665
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96412225
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.95851852
87SPI1_20517297_ChIP-Seq_HL60_Human0.95645718
88ZFX_18555785_Chip-Seq_ESCs_Mouse0.94911056
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94442349
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94382070
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93754296
92P53_22387025_ChIP-Seq_ESCs_Mouse0.93702587
93OCT4_20526341_ChIP-Seq_ESCs_Human0.93418614
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93119477
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92641415
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92421204
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.92190362
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91512473
99GATA1_22025678_ChIP-Seq_K562_Human0.91039028
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.90145201
101SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90072225
102CTCF_21964334_Chip-Seq_Bcells_Human0.88568890
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86841574
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86716040
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86019848
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86019848
107* FOXH1_21741376_ChIP-Seq_ESCs_Human0.85792933
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85407668
109P68_20966046_ChIP-Seq_HELA_Human0.84853287
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.83075573
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.82715177
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82650357
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82214440
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81984319
115NFI_21473784_ChIP-Seq_ESCs_Mouse0.81864390
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81684277
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81419758
118MYC_27129775_Chip-Seq_CORNEA_Mouse0.81232996
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.80745740
120SA1_27219007_Chip-Seq_Bcells_Human0.80556355
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80414455
122GBX2_23144817_ChIP-Seq_PC3_Human0.80103662
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80004995
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79755481
125BCL6_27268052_Chip-Seq_Bcells_Human0.78936150
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78786109
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78727337
128* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78206556
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77982822
130HTT_18923047_ChIP-ChIP_STHdh_Human0.77813178
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77742849
132SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77343455
133PU1_27457419_Chip-Seq_LIVER_Mouse0.77317888
134RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77254455
135SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77219234
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77151204
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77123096
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.76820444
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.76812087
140SOX11_22085726_ChIP-Seq_ESNs_Mouse0.76629920
141CBP_20019798_ChIP-Seq_JUKART_Human0.76499683
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76109613
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75803116
144GATA2_19941826_ChIP-Seq_K562_Human0.75422976
145EZH2_27294783_Chip-Seq_ESCs_Mouse0.73300357
146GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72842120
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72569373
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71473230
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.71310965
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.71241816
151E2F1_20622854_ChIP-Seq_HELA_Human0.71078828
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70885579
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70885579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.55087101
2MP0004084_abnormal_cardiac_muscle5.62533575
3MP0003646_muscle_fatigue5.48355281
4* MP0000751_myopathy4.95547193
5MP0004036_abnormal_muscle_relaxation4.53457082
6* MP0000749_muscle_degeneration4.48488399
7MP0004215_abnormal_myocardial_fiber4.39140524
8* MP0005330_cardiomyopathy3.67667426
9* MP0004087_abnormal_muscle_fiber3.34565375
10MP0004145_abnormal_muscle_electrophysio3.33089754
11MP0000750_abnormal_muscle_regeneration3.13689291
12* MP0002972_abnormal_cardiac_muscle3.03600729
13* MP0002106_abnormal_muscle_physiology2.93657998
14* MP0005620_abnormal_muscle_contractility2.93565343
15MP0003137_abnormal_impulse_conducting2.71897860
16MP0008775_abnormal_heart_ventricle2.69493447
17MP0000747_muscle_weakness2.66543312
18MP0005385_cardiovascular_system_phenoty2.48188999
19MP0001544_abnormal_cardiovascular_syste2.48188999
20* MP0010630_abnormal_cardiac_muscle2.47982904
21* MP0002269_muscular_atrophy2.43338864
22* MP0000759_abnormal_skeletal_muscle2.43140607
23* MP0005369_muscle_phenotype2.41068984
24MP0004130_abnormal_muscle_cell2.39998949
25MP0004484_altered_response_of2.38705005
26MP0006138_congestive_heart_failure2.25227661
27MP0003828_pulmonary_edema2.09105672
28MP0004233_abnormal_muscle_weight1.97129493
29MP0004085_abnormal_heartbeat1.92104081
30MP0003221_abnormal_cardiomyocyte_apopto1.85257025
31MP0004510_myositis1.75035840
32MP0006036_abnormal_mitochondrial_physio1.69671098
33MP0002127_abnormal_cardiovascular_syste1.67036464
34MP0002332_abnormal_exercise_endurance1.52310123
35MP0003567_abnormal_fetal_cardiomyocyte1.31102958
36MP0000733_abnormal_muscle_development1.30215117
37MP0002108_abnormal_muscle_morphology1.24371057
38MP0005666_abnormal_adipose_tissue1.24006769
39MP0003279_aneurysm1.19057012
40MP0002234_abnormal_pharynx_morphology1.16267683
41MP0010030_abnormal_orbit_morphology1.14032878
42* MP0000266_abnormal_heart_morphology1.11740739
43MP0000343_altered_response_to1.09455180
44MP0001542_abnormal_bone_strength1.08572820
45MP0008438_abnormal_cutaneous_collagen1.08184681
46MP0010368_abnormal_lymphatic_system1.04212930
47MP0006035_abnormal_mitochondrial_morpho0.94437659
48MP0005165_increased_susceptibility_to0.92003060
49MP0004185_abnormal_adipocyte_glucose0.91943343
50MP0005670_abnormal_white_adipose0.90646537
51* MP0003950_abnormal_plasma_membrane0.89975433
52MP0003705_abnormal_hypodermis_morpholog0.89141470
53MP0005375_adipose_tissue_phenotype0.87498540
54MP0001661_extended_life_span0.86034660
55MP0005275_abnormal_skin_tensile0.85990252
56MP0002102_abnormal_ear_morphology0.85791059
57MP0005623_abnormal_meninges_morphology0.83680379
58MP0005266_abnormal_metabolism0.83432629
59MP0002249_abnormal_larynx_morphology0.83132745
60MP0003566_abnormal_cell_adhesion0.81638930
61MP0002128_abnormal_blood_circulation0.78559972
62MP0004272_abnormal_basement_membrane0.77215539
63MP0000230_abnormal_systemic_arterial0.72754625
64MP0002822_catalepsy0.71847296
65MP0000013_abnormal_adipose_tissue0.70739045
66MP0003806_abnormal_nucleotide_metabolis0.70667479
67MP0005451_abnormal_body_composition0.70660859
68MP0002971_abnormal_brown_adipose0.68910672
69MP0000767_abnormal_smooth_muscle0.67355592
70MP0002734_abnormal_mechanical_nocicepti0.65966186
71MP0001879_abnormal_lymphatic_vessel0.61830811
72MP0008789_abnormal_olfactory_epithelium0.60401888
73MP0004134_abnormal_chest_morphology0.60321426
74MP0005503_abnormal_tendon_morphology0.60256004
75MP0002896_abnormal_bone_mineralization0.59721160
76MP0002114_abnormal_axial_skeleton0.58099711
77MP0000003_abnormal_adipose_tissue0.54928249
78MP0000467_abnormal_esophagus_morphology0.51363331
79MP0002925_abnormal_cardiovascular_devel0.48377038
80MP0004043_abnormal_pH_regulation0.45442675
81MP0002933_joint_inflammation0.45430786
82MP0009384_cardiac_valve_regurgitation0.45231810
83MP0002909_abnormal_adrenal_gland0.43719604
84MP0000372_irregular_coat_pigmentation0.42421717
85MP0009250_abnormal_appendicular_skeleto0.40929194
86MP0001943_abnormal_respiration0.40634924
87MP0005166_decreased_susceptibility_to0.40597627
88MP0004147_increased_porphyrin_level0.40113959
89MP0003879_abnormal_hair_cell0.39879183
90MP0002078_abnormal_glucose_homeostasis0.39267515
91MP0001614_abnormal_blood_vessel0.38943893
92MP0001784_abnormal_fluid_regulation0.38026071
93MP0004883_abnormal_blood_vessel0.37774498
94MP0005187_abnormal_penis_morphology0.35270771
95MP0003948_abnormal_gas_homeostasis0.35256924
96MP0001958_emphysema0.34649136
97MP0003984_embryonic_growth_retardation0.34470206
98MP0002088_abnormal_embryonic_growth/wei0.33777293
99MP0001485_abnormal_pinna_reflex0.33093077
100MP0008961_abnormal_basal_metabolism0.32637529
101* MP0005319_abnormal_enzyme/_coenzyme0.32314289
102MP0003959_abnormal_lean_body0.30462871
103MP0005595_abnormal_vascular_smooth0.29133493
104MP0005376_homeostasis/metabolism_phenot0.28844472
105MP0001346_abnormal_lacrimal_gland0.28415362
106MP0003011_delayed_dark_adaptation0.26074712
107MP0002877_abnormal_melanocyte_morpholog0.25182541
108MP0001299_abnormal_eye_distance/0.24730059
109MP0000762_abnormal_tongue_morphology0.24257688
110MP0004142_abnormal_muscle_tone0.24012189
111MP0009780_abnormal_chondrocyte_physiolo0.23860372
112MP0001727_abnormal_embryo_implantation0.23620366
113MP0000249_abnormal_blood_vessel0.21884174
114MP0008770_decreased_survivor_rate0.21217470
115MP0003385_abnormal_body_wall0.20856496
116MP0005334_abnormal_fat_pad0.20495010
117MP0003045_fibrosis0.20494433
118MP0003941_abnormal_skin_development0.20151914
119MP0005535_abnormal_body_temperature0.19513619
120MP0004858_abnormal_nervous_system0.18562155
121MP0005452_abnormal_adipose_tissue0.18557765
122MP0005377_hearing/vestibular/ear_phenot0.18141084
123MP0003878_abnormal_ear_physiology0.18141084
124MP0002133_abnormal_respiratory_system0.17323733
125MP0005388_respiratory_system_phenotype0.17323733
126MP0004270_analgesia0.16397002
127MP0009115_abnormal_fat_cell0.16304773
128MP0002295_abnormal_pulmonary_circulatio0.16288306

Predicted human phenotypes

RankGene SetZ-score
1* Sudden death (HP:0001699)6.89378813
2Muscle fiber splitting (HP:0003555)6.14511619
3Ventricular tachycardia (HP:0004756)5.96106794
4* Calf muscle hypertrophy (HP:0008981)5.92241204
5* Exercise-induced myalgia (HP:0003738)5.79330380
6Popliteal pterygium (HP:0009756)5.73928604
7* Muscle hypertrophy of the lower extremities (HP:0008968)5.63526937
8Muscle fiber inclusion bodies (HP:0100299)5.56246486
9* Exercise-induced muscle cramps (HP:0003710)5.55089583
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.52225802
11Hyporeflexia of lower limbs (HP:0002600)5.51777722
12Type 1 muscle fiber predominance (HP:0003803)5.39755486
13* Abnormality of the calf musculature (HP:0001430)5.27393171
14Atrial fibrillation (HP:0005110)5.08508763
15EMG: myopathic abnormalities (HP:0003458)5.03532308
16Nemaline bodies (HP:0003798)4.97320119
17Type 2 muscle fiber atrophy (HP:0003554)4.90757316
18Lipoatrophy (HP:0100578)4.86300625
19Myoglobinuria (HP:0002913)4.82006547
20Fetal akinesia sequence (HP:0001989)4.78801765
21Primary atrial arrhythmia (HP:0001692)4.75185768
22Supraventricular tachycardia (HP:0004755)4.58944950
23Supraventricular arrhythmia (HP:0005115)4.50800787
24Muscle fiber atrophy (HP:0100295)4.44961572
25Difficulty running (HP:0009046)4.36318514
26Amniotic constriction ring (HP:0009775)4.35392828
27Abnormality of placental membranes (HP:0011409)4.35392828
28Increased connective tissue (HP:0009025)4.35273077
29Right ventricular cardiomyopathy (HP:0011663)4.33236561
30Distal arthrogryposis (HP:0005684)4.23148448
31* Abnormality of the left ventricular outflow tract (HP:0011103)4.09355856
32* Subaortic stenosis (HP:0001682)4.09355856
33Dilated cardiomyopathy (HP:0001644)4.08182225
34Syncope (HP:0001279)3.99285731
35Abnormal finger flexion creases (HP:0006143)3.84662040
36Bundle branch block (HP:0011710)3.81140118
37Palpitations (HP:0001962)3.81031116
38Rhabdomyolysis (HP:0003201)3.78589529
39Difficulty climbing stairs (HP:0003551)3.49680170
40Round ear (HP:0100830)3.46075344
41* Ventricular arrhythmia (HP:0004308)3.33126802
42* Prolonged QT interval (HP:0001657)3.29091591
43Heart block (HP:0012722)3.19711757
44Aplasia of the musculature (HP:0100854)3.18043853
45Abnormality of skeletal muscle fiber size (HP:0012084)3.17480058
46Abnormality of the calcaneus (HP:0008364)3.15315782
47Ventricular fibrillation (HP:0001663)3.13310278
48Increased variability in muscle fiber diameter (HP:0003557)3.06834125
49Abnormal atrioventricular conduction (HP:0005150)3.05401585
50Myopathic facies (HP:0002058)3.04597529
51* Asymmetric septal hypertrophy (HP:0001670)3.02342324
52Atrioventricular block (HP:0001678)3.01754913
53Metatarsus adductus (HP:0001840)3.00582714
54Easy fatigability (HP:0003388)2.93960259
55* Neck muscle weakness (HP:0000467)2.88766096
56Mildly elevated creatine phosphokinase (HP:0008180)2.87159626
57Distal lower limb muscle weakness (HP:0009053)2.85024762
58* Myotonia (HP:0002486)2.82043484
59Areflexia of lower limbs (HP:0002522)2.80465869
60Ulnar deviation of the wrist (HP:0003049)2.74052858
61Left ventricular hypertrophy (HP:0001712)2.61000028
62EMG: neuropathic changes (HP:0003445)2.60096224
63Abnormal mitochondria in muscle tissue (HP:0008316)2.58855506
64Generalized muscle weakness (HP:0003324)2.58613389
65Acute necrotizing encephalopathy (HP:0006965)2.57631402
66Rimmed vacuoles (HP:0003805)2.56204544
67Nonprogressive disorder (HP:0003680)2.54334935
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.54193341
69Pterygium (HP:0001059)2.53506758
70Limb-girdle muscle atrophy (HP:0003797)2.48373737
71Thin ribs (HP:0000883)2.47050642
72Hepatic necrosis (HP:0002605)2.41603244
73* Abnormal EKG (HP:0003115)2.38204996
74Palmoplantar keratoderma (HP:0000982)2.36940377
75Respiratory insufficiency due to muscle weakness (HP:0002747)2.34410517
76Scapular winging (HP:0003691)2.33785844
77* Muscle stiffness (HP:0003552)2.32519789
78Conjunctival hamartoma (HP:0100780)2.26451512
79Akinesia (HP:0002304)2.25570959
80Distal lower limb amyotrophy (HP:0008944)2.23711355
81Hypoplastic ischia (HP:0003175)2.23225505
82Muscular dystrophy (HP:0003560)2.23108370
83Frequent falls (HP:0002359)2.22333179
84Calcaneovalgus deformity (HP:0001848)2.21406735
85Ragged-red muscle fibers (HP:0003200)2.20327794
86Acute encephalopathy (HP:0006846)2.16801232
87Hip contracture (HP:0003273)2.15069348
88Abnormality of the foot musculature (HP:0001436)2.14859547
89Spinal rigidity (HP:0003306)2.14110367
90Progressive macrocephaly (HP:0004481)2.12672164
91Facial diplegia (HP:0001349)2.12086799
92* Gowers sign (HP:0003391)2.12011964
93Bulbar palsy (HP:0001283)2.11409919
94Testicular atrophy (HP:0000029)2.10266215
95Hepatocellular necrosis (HP:0001404)2.10009360
96Trismus (HP:0000211)2.09757075
97Exercise intolerance (HP:0003546)2.08984500
98Ketoacidosis (HP:0001993)2.07571082
99Mitochondrial inheritance (HP:0001427)2.05482944
100Absent phalangeal crease (HP:0006109)2.05283767
101Breech presentation (HP:0001623)2.04010041
102Progressive muscle weakness (HP:0003323)2.01925580
103Weak cry (HP:0001612)2.01264748
104Proximal amyotrophy (HP:0007126)2.00672239
105Malignant hyperthermia (HP:0002047)2.00399799
106Fatigable weakness (HP:0003473)2.00096589
107Abnormality of the neuromuscular junction (HP:0003398)2.00096589
108Limited hip movement (HP:0008800)1.99950601
109Foot dorsiflexor weakness (HP:0009027)1.99423671
110Increased muscle lipid content (HP:0009058)1.97991297
111Hypoglycemic coma (HP:0001325)1.96502474
112Deformed tarsal bones (HP:0008119)1.95910146
113Poor suck (HP:0002033)1.94707780
114Pheochromocytoma (HP:0002666)1.94018937
115Increased CSF lactate (HP:0002490)1.93838576
116Slender build (HP:0001533)1.93743535
117Abnormality of the ischium (HP:0003174)1.93091927
118Waddling gait (HP:0002515)1.93054396
119Long clavicles (HP:0000890)1.91545208
120Cerebral edema (HP:0002181)1.89536172
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89452793
122Cystic hygroma (HP:0000476)1.87373785
123Limb-girdle muscle weakness (HP:0003325)1.85248408
124Abnormality of the shoulder girdle musculature (HP:0001435)1.84593638
125Aortic aneurysm (HP:0004942)1.83872195
126Sudden cardiac death (HP:0001645)1.83310701
127Rocker bottom foot (HP:0001838)1.79854597
128Webbed neck (HP:0000465)1.76937462
129Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75498501
130Hypoplastic heart (HP:0001961)1.68380932
131Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.68180669
132Lower limb amyotrophy (HP:0007210)1.67729659
133Ulnar deviation of finger (HP:0009465)1.66927331
134Arterial tortuosity (HP:0005116)1.61161202
135Steppage gait (HP:0003376)1.61158505
136Increased serum pyruvate (HP:0003542)1.55690386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.57034794
2TTN5.90006611
3PHKG24.03269672
4PHKG14.03269672
5MYLK3.47430729
6CCNB13.17016737
7PDK43.06085542
8PDK33.06085542
9DMPK2.96690021
10PKN22.83710679
11TRIB32.83674021
12LMTK22.82851749
13MUSK2.73305765
14MAPKAPK52.62121860
15STK242.39839433
16PIK3CA2.31468315
17NEK12.30415215
18CDK82.18865822
19BCKDK1.98718405
20PDK21.84344792
21TIE11.82781597
22PINK11.72294843
23PIK3CG1.62231852
24ILK1.37102360
25MAP2K31.27287163
26MAP3K71.26571575
27MAPK121.24407967
28NME11.17665884
29PAK31.16739894
30STK38L1.10161753
31PRKD11.08016451
32ZAK1.07878700
33CDC42BPA1.05112627
34ROCK11.04520313
35CAMK2D0.99616734
36MAPKAPK30.96927302
37TRPM70.94671080
38GRK70.92511499
39MARK10.87554023
40DAPK30.87249831
41MAP3K50.86680204
42MELK0.85900683
43SCYL20.85405917
44RIPK10.84547202
45PRKAA10.82881271
46MAP3K30.82491528
47EEF2K0.79663847
48PRKAA20.73209277
49PAK60.72262939
50STK40.70210547
51FLT30.70100127
52WNK40.68318114
53PDGFRA0.67478715
54PKN10.62384283
55INSRR0.62241677
56ROCK20.61592257
57EPHB10.61333051
58CDK90.61146346
59MAPK40.59889972
60PTK2B0.57277691
61DDR20.55819064
62MARK20.54929242
63MAP3K100.54623088
64TGFBR20.53196579
65STK380.51504688
66CAMK40.49675935
67CAMK2B0.49355503
68AKT20.48102321
69CAMK2A0.47869556
70SIK10.45463576
71WNK10.43508260
72RPS6KL10.41865522
73RPS6KC10.41865522
74KDR0.41755817
75ERBB30.41346240
76NEK90.41067083
77PTK60.40636898
78ARAF0.40304177
79CAMK2G0.39698173
80LIMK10.38825123
81CAMK10.36430933
82ICK0.36132259
83DYRK1B0.35164455
84RPS6KA60.35020459
85PRKACA0.34560009
86* PRKACB0.33360489
87NME20.33016175
88MAP2K40.32605016
89PRKD30.32250264
90CDK40.32059625
91MAP3K120.31404798
92EPHB20.31344916
93PDPK10.31084381
94PRKCE0.29559988
95LATS20.29242442
96PRKACG0.26704771
97LATS10.25311941
98MAPK110.24854164
99MAP3K130.24501370
100PRKG10.24114048
101PDK10.23118958
102STK390.22297042
103PRKCH0.22058315
104MAP2K60.21866283
105PAK20.21831456
106TNK20.21518649
107MTOR0.21396157
108FER0.20849488
109PRKG20.19347442
110MAP2K10.19252278
111LRRK20.19066185
112RPS6KA10.18912382
113DAPK20.18660602
114MAPK70.15684272
115EIF2AK30.14626769
116MOS0.14566501
117RPS6KA30.14286175
118MAPK100.13710170
119MAPK130.13464017
120SGK10.11960313
121SGK30.11260627
122PTK20.11190586
123STK160.11179199
124RET0.10822132
125MAP3K110.10801951
126FGFR40.09912015
127KSR20.09546898
128TAOK10.09168159
129RPS6KB10.08888801
130JAK10.08819559
131PLK20.08318910
132PRKCA0.06464611
133SGK20.06212921
134CDK11A0.05529826
135ABL10.05250627
136RPS6KB20.04812340
137CDK190.04159822
138FGFR10.03704628
139MAPK80.02446917
140PRKDC0.01523077

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.73774924
2Cardiac muscle contraction_Homo sapiens_hsa042604.75571294
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.18241555
4Dilated cardiomyopathy_Homo sapiens_hsa054144.14834198
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.08911269
6Parkinsons disease_Homo sapiens_hsa050123.29543490
7Oxidative phosphorylation_Homo sapiens_hsa001903.15226818
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92733487
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.82632996
10Propanoate metabolism_Homo sapiens_hsa006402.82153575
11Fatty acid degradation_Homo sapiens_hsa000712.48232682
12Alzheimers disease_Homo sapiens_hsa050102.44423844
13Carbon metabolism_Homo sapiens_hsa012002.39222576
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22343794
15Huntingtons disease_Homo sapiens_hsa050162.01849393
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.97614188
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88329719
18Viral myocarditis_Homo sapiens_hsa054161.85169533
19Fatty acid metabolism_Homo sapiens_hsa012121.81803121
20Pyruvate metabolism_Homo sapiens_hsa006201.65078943
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40891813
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32290612
23Starch and sucrose metabolism_Homo sapiens_hsa005001.23581137
24Biosynthesis of amino acids_Homo sapiens_hsa012301.19143194
25Glucagon signaling pathway_Homo sapiens_hsa049221.17737461
26Insulin resistance_Homo sapiens_hsa049311.13602302
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10395299
28Histidine metabolism_Homo sapiens_hsa003401.05337019
29Butanoate metabolism_Homo sapiens_hsa006501.04126453
30Insulin signaling pathway_Homo sapiens_hsa049101.03620215
31Fatty acid elongation_Homo sapiens_hsa000620.99984515
32Adipocytokine signaling pathway_Homo sapiens_hsa049200.99940335
33Tight junction_Homo sapiens_hsa045300.90597910
34* Focal adhesion_Homo sapiens_hsa045100.88001915
35PPAR signaling pathway_Homo sapiens_hsa033200.86099404
36Oxytocin signaling pathway_Homo sapiens_hsa049210.85799864
37Calcium signaling pathway_Homo sapiens_hsa040200.83979817
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83764253
39HIF-1 signaling pathway_Homo sapiens_hsa040660.79475829
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78344126
41AMPK signaling pathway_Homo sapiens_hsa041520.76037163
42Nitrogen metabolism_Homo sapiens_hsa009100.75677196
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75096572
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.73162238
45Galactose metabolism_Homo sapiens_hsa000520.69690649
46Arginine and proline metabolism_Homo sapiens_hsa003300.64882604
47ECM-receptor interaction_Homo sapiens_hsa045120.63984188
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63964310
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.61329677
50Lysine degradation_Homo sapiens_hsa003100.61141713
51Salivary secretion_Homo sapiens_hsa049700.60888910
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59675181
53Arginine biosynthesis_Homo sapiens_hsa002200.58739201
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57284226
55Tryptophan metabolism_Homo sapiens_hsa003800.56846259
56beta-Alanine metabolism_Homo sapiens_hsa004100.54637876
57Long-term potentiation_Homo sapiens_hsa047200.54615542
58Selenocompound metabolism_Homo sapiens_hsa004500.54504424
59Fructose and mannose metabolism_Homo sapiens_hsa000510.52169189
60Type II diabetes mellitus_Homo sapiens_hsa049300.50856399
61Phenylalanine metabolism_Homo sapiens_hsa003600.46693267
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46634476
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45611851
64Amoebiasis_Homo sapiens_hsa051460.45546885
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43988641
66Renin secretion_Homo sapiens_hsa049240.42982149
67Gastric acid secretion_Homo sapiens_hsa049710.42279806
68Circadian rhythm_Homo sapiens_hsa047100.42009014
69Adherens junction_Homo sapiens_hsa045200.41932833
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40270747
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36935565
72Insulin secretion_Homo sapiens_hsa049110.36827249
73Fatty acid biosynthesis_Homo sapiens_hsa000610.36378032
74cAMP signaling pathway_Homo sapiens_hsa040240.35172660
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.34149075
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32721477
77Peroxisome_Homo sapiens_hsa041460.31445658
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31212073
79Amphetamine addiction_Homo sapiens_hsa050310.25595863
80Melanogenesis_Homo sapiens_hsa049160.25468115
81GnRH signaling pathway_Homo sapiens_hsa049120.24856428
82* Proteoglycans in cancer_Homo sapiens_hsa052050.24152584
83* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23321886
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23235485
85ABC transporters_Homo sapiens_hsa020100.22846345
86Platelet activation_Homo sapiens_hsa046110.22539588
87Long-term depression_Homo sapiens_hsa047300.22235185
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20584954
89Metabolic pathways_Homo sapiens_hsa011000.19838656
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19623653
91Colorectal cancer_Homo sapiens_hsa052100.19339451
92VEGF signaling pathway_Homo sapiens_hsa043700.19108293
93mTOR signaling pathway_Homo sapiens_hsa041500.18134631
94Circadian entrainment_Homo sapiens_hsa047130.18113274
95Renal cell carcinoma_Homo sapiens_hsa052110.17990717
96Glioma_Homo sapiens_hsa052140.17867799
97Olfactory transduction_Homo sapiens_hsa047400.15836096
98Wnt signaling pathway_Homo sapiens_hsa043100.15303600
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14923235
100Tyrosine metabolism_Homo sapiens_hsa003500.14132992
101Ovarian steroidogenesis_Homo sapiens_hsa049130.14059124
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13982314
103Phototransduction_Homo sapiens_hsa047440.13770275
104FoxO signaling pathway_Homo sapiens_hsa040680.13576605
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12601105
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11945912
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11270077
108Gap junction_Homo sapiens_hsa045400.09468168
109Protein digestion and absorption_Homo sapiens_hsa049740.08823222
110Cholinergic synapse_Homo sapiens_hsa047250.08806761
111MAPK signaling pathway_Homo sapiens_hsa040100.08762066
112Bile secretion_Homo sapiens_hsa049760.07911315
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.07234628
114Pentose phosphate pathway_Homo sapiens_hsa000300.06945409
115Pancreatic secretion_Homo sapiens_hsa049720.06635477
116Small cell lung cancer_Homo sapiens_hsa052220.04566939
117Toxoplasmosis_Homo sapiens_hsa051450.04318772
118Fat digestion and absorption_Homo sapiens_hsa049750.04127876
119Dorso-ventral axis formation_Homo sapiens_hsa043200.03440864
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03282527
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02159683

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