CBFA2T3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.81597903
2definitive hemopoiesis (GO:0060216)5.86059259
3megakaryocyte development (GO:0035855)5.43796687
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73922984
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.71256436
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.71256436
7modulation by symbiont of host immune response (GO:0052553)4.71256436
8positive regulation by symbiont of host defense response (GO:0052509)4.71256436
9modulation by symbiont of host defense response (GO:0052031)4.71256436
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.71256436
11response to peptidoglycan (GO:0032494)4.61136315
12negative regulation of erythrocyte differentiation (GO:0045647)4.45118253
13antigen processing and presentation of endogenous antigen (GO:0019883)4.34090840
14positive regulation of B cell differentiation (GO:0045579)4.29073164
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.22379483
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.22379483
17antigen processing and presentation via MHC class Ib (GO:0002475)4.21939927
18viral transcription (GO:0019083)4.19485529
19positive regulation of gamma-delta T cell activation (GO:0046645)4.12012756
20detection of bacterium (GO:0016045)4.10670571
21negative regulation of cell killing (GO:0031342)4.08585554
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08585554
23response to interferon-beta (GO:0035456)4.07655621
24lymphoid progenitor cell differentiation (GO:0002320)4.04908892
25detection of other organism (GO:0098543)4.00492298
26platelet dense granule organization (GO:0060155)3.99306027
27response to muramyl dipeptide (GO:0032495)3.92711857
28embryonic hemopoiesis (GO:0035162)3.91302436
29mature B cell differentiation involved in immune response (GO:0002313)3.87691789
30translational termination (GO:0006415)3.85940670
31regulation of mast cell activation involved in immune response (GO:0033006)3.78080790
32T cell homeostasis (GO:0043029)3.77940063
33regulation of erythrocyte differentiation (GO:0045646)3.74762419
34ribosomal small subunit biogenesis (GO:0042274)3.72202007
35mature B cell differentiation (GO:0002335)3.69278107
36regulation of granulocyte differentiation (GO:0030852)3.62336912
37regulation of B cell receptor signaling pathway (GO:0050855)3.61530372
38positive thymic T cell selection (GO:0045059)3.60533645
39leukocyte aggregation (GO:0070486)3.60465544
40macrophage activation involved in immune response (GO:0002281)3.59947928
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59189852
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59169236
43negative regulation of phagocytosis (GO:0050765)3.59144108
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.54211968
45response to host immune response (GO:0052572)3.52781645
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52781645
47germinal center formation (GO:0002467)3.51487955
48regulation of B cell differentiation (GO:0045577)3.49929142
49lymph node development (GO:0048535)3.49848287
50cotranslational protein targeting to membrane (GO:0006613)3.46268600
51protein targeting to ER (GO:0045047)3.46120826
52regulation of leukocyte degranulation (GO:0043300)3.44876342
53positive regulation of mast cell activation (GO:0033005)3.40964777
54mast cell activation (GO:0045576)3.37987521
55endosome to melanosome transport (GO:0035646)3.37767990
56endosome to pigment granule transport (GO:0043485)3.37767990
57myeloid dendritic cell activation (GO:0001773)3.35241934
58defense response to protozoan (GO:0042832)3.31644060
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30327855
60positive regulation of mast cell degranulation (GO:0043306)3.29734914
61positive regulation of mast cell activation involved in immune response (GO:0033008)3.29734914
62regulation of mast cell activation (GO:0033003)3.29443755
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29044278
64protein localization to endoplasmic reticulum (GO:0070972)3.28968457
65B cell mediated immunity (GO:0019724)3.27644317
66DNA deamination (GO:0045006)3.26038890
67translational elongation (GO:0006414)3.25448062
68regulation of interferon-beta biosynthetic process (GO:0045357)3.24554017
69negative thymic T cell selection (GO:0045060)3.23061820
70B cell receptor signaling pathway (GO:0050853)3.22540819
71secretory granule organization (GO:0033363)3.21409240
72response to type I interferon (GO:0034340)3.21294396
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21284231
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.20282790
75cellular response to type I interferon (GO:0071357)3.18747289
76type I interferon signaling pathway (GO:0060337)3.18747289
77response to protozoan (GO:0001562)3.18084131
78negative regulation of T cell mediated immunity (GO:0002710)3.17610474
79response to host (GO:0075136)3.17489854
80response to host defenses (GO:0052200)3.17489854
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.17489854
82neutrophil activation (GO:0042119)3.16471809
83CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.15473430
84regulation of antigen processing and presentation (GO:0002577)3.14049597
85cellular response to interferon-beta (GO:0035458)3.13619630
86mast cell degranulation (GO:0043303)3.11805801
87mast cell activation involved in immune response (GO:0002279)3.11805801
88regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09456917
89myeloid cell activation involved in immune response (GO:0002275)3.07789508
90regulation of regulated secretory pathway (GO:1903305)3.06791028
91thymic T cell selection (GO:0045061)3.05687514
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.04999713
93viral life cycle (GO:0019058)3.04899030
94T cell selection (GO:0045058)3.02870860
95* granulocyte differentiation (GO:0030851)3.01874398
96maturation of SSU-rRNA (GO:0030490)3.01115572
97Peyers patch development (GO:0048541)3.01088515
98mucosal-associated lymphoid tissue development (GO:0048537)3.01088515
99detection of external biotic stimulus (GO:0098581)3.00589004
100cellular extravasation (GO:0045123)3.00021675
101negative T cell selection (GO:0043383)2.99183025
102respiratory burst (GO:0045730)2.98366147
103myeloid cell development (GO:0061515)2.98050938
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97229800
105negative regulation of interleukin-12 production (GO:0032695)2.95622359
1063-UTR-mediated mRNA stabilization (GO:0070935)2.94682740
107myeloid dendritic cell differentiation (GO:0043011)2.93483933
108cellular protein complex disassembly (GO:0043624)2.93146182
109response to interleukin-15 (GO:0070672)2.92778241
110leukocyte degranulation (GO:0043299)2.92605115
111regulation of gamma-delta T cell differentiation (GO:0045586)2.91498959
112positive regulation of granulocyte differentiation (GO:0030854)2.91373209
113negative regulation of leukocyte mediated immunity (GO:0002704)2.90767675
114positive regulation of B cell activation (GO:0050871)2.89653161
115negative regulation of viral genome replication (GO:0045071)2.89109612
116response to interferon-alpha (GO:0035455)2.87828246
117energy homeostasis (GO:0097009)2.86859335
118immunoglobulin mediated immune response (GO:0016064)2.86720559
119Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86442591
120positive regulation of antigen processing and presentation (GO:0002579)2.86292260
121leukocyte homeostasis (GO:0001776)2.85309366
122erythrocyte maturation (GO:0043249)2.83968408
123protoporphyrinogen IX biosynthetic process (GO:0006782)2.83828792
124lymphocyte homeostasis (GO:0002260)2.83723284
125protein complex disassembly (GO:0043241)2.83684186
126positive regulation of respiratory burst (GO:0060267)2.83658139
127histone H3-K4 trimethylation (GO:0080182)2.83128596
128neutrophil activation involved in immune response (GO:0002283)2.80222421
129respiratory chain complex IV assembly (GO:0008535)2.79970796
130regulation of B cell apoptotic process (GO:0002902)2.79866996
131NIK/NF-kappaB signaling (GO:0038061)2.79435983
132natural killer cell differentiation (GO:0001779)2.79194558
133protein-DNA complex disassembly (GO:0032986)2.78858464
134nucleosome disassembly (GO:0006337)2.78858464
135execution phase of apoptosis (GO:0097194)2.78855099
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.78735783
137cellular response to exogenous dsRNA (GO:0071360)2.78612098
138granulocyte activation (GO:0036230)2.78606607
139positive T cell selection (GO:0043368)2.77047360
140negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76968238
141regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76230850
142regulation of gamma-delta T cell activation (GO:0046643)2.75592478
143deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75250751
144B cell differentiation (GO:0030183)2.74707500
145interferon-gamma-mediated signaling pathway (GO:0060333)2.73322751
146positive regulation of regulated secretory pathway (GO:1903307)2.69213248
147histamine transport (GO:0051608)2.68977662
148positive regulation of Rap GTPase activity (GO:0032854)2.68932141
149positive regulation of erythrocyte differentiation (GO:0045648)2.67040961
150antigen receptor-mediated signaling pathway (GO:0050851)2.66793210
151erythrocyte differentiation (GO:0030218)2.66699206
152macromolecular complex disassembly (GO:0032984)2.66014568
153negative regulation of multicellular organism growth (GO:0040015)2.65287561
154T cell lineage commitment (GO:0002360)2.63582315
155regulation of mast cell degranulation (GO:0043304)2.61184128
156regulation of necroptotic process (GO:0060544)2.59415562
157dendritic cell differentiation (GO:0097028)2.56888092
158translational initiation (GO:0006413)2.54615893
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53531228
160positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.53490087
161regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53260054
162positive regulation of megakaryocyte differentiation (GO:0045654)2.52580041
163cellular response to thyroid hormone stimulus (GO:0097067)2.50114697
164negative regulation of granulocyte differentiation (GO:0030853)2.49709628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SCL_19346495_ChIP-Seq_HPC-7_Human5.42359655
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.32282873
3E2F7_22180533_ChIP-Seq_HELA_Human4.12186231
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91410593
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73316746
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.45598045
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27917621
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.11612026
9* MYC_22102868_ChIP-Seq_BL_Human3.10022655
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.09061522
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06844548
12* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.05627354
13VDR_21846776_ChIP-Seq_THP-1_Human2.87814969
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.87168812
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.85089137
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.69435100
17* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.65879572
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.48657280
19GATA1_22025678_ChIP-Seq_K562_Human2.45482538
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.40982293
21* SPI1_23547873_ChIP-Seq_NB4_Human2.40792607
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.40120211
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39193986
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.34411167
25TCF7_22412390_ChIP-Seq_EML_Mouse2.27261786
26VDR_24763502_ChIP-Seq_THP-1_Human2.19992185
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18792247
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16909534
29* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.13102224
30* GATA1_19941827_ChIP-Seq_MEL_Mouse2.11429572
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10984321
32GATA1_22383799_ChIP-Seq_G1ME_Mouse2.09312660
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.07476911
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05997426
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04098856
36MAF_26560356_Chip-Seq_TH1_Human2.02432729
37RUNX1_22412390_ChIP-Seq_EML_Mouse2.02202201
38CIITA_25753668_ChIP-Seq_RAJI_Human2.00158836
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.96586657
40* MYB_26560356_Chip-Seq_TH2_Human1.93761678
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93395747
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88175735
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87557257
44MYB_26560356_Chip-Seq_TH1_Human1.84807061
45* LXR_22292898_ChIP-Seq_THP-1_Human1.84017338
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82010462
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.80002276
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79100123
49SPI1_23127762_ChIP-Seq_K562_Human1.77816541
50UTX_26944678_Chip-Seq_JUKART_Human1.76468504
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.74449408
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68471136
53* NCOR1_26117541_ChIP-Seq_K562_Human1.68402614
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68387489
55RUNX_20019798_ChIP-Seq_JUKART_Human1.63504056
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.62515753
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.57545658
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55672233
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54352873
60* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49033319
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48146437
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47111444
63P68_20966046_ChIP-Seq_HELA_Human1.45963341
64BCOR_27268052_Chip-Seq_Bcells_Human1.40612014
65VDR_23849224_ChIP-Seq_CD4+_Human1.35027057
66MAF_26560356_Chip-Seq_TH2_Human1.30958046
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29875353
68FOXP3_21729870_ChIP-Seq_TREG_Human1.29426734
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26030524
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.25469876
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23690669
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21181472
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21159964
74* GATA2_21666600_ChIP-Seq_HMVEC_Human1.21063617
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20319252
76* GATA2_19941826_ChIP-Seq_K562_Human1.19756346
77ETS1_22383799_ChIP-Seq_G1ME_Mouse1.19074321
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18719037
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.18663507
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16639650
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16401018
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15741405
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14805295
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14557339
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.13973021
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13178198
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.13107334
88* KDM2B_26808549_Chip-Seq_DND41_Human1.12239818
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11321154
90* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10435198
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08551132
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07845815
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.07674487
94PU_27001747_Chip-Seq_BMDM_Mouse1.06939370
95RACK7_27058665_Chip-Seq_MCF-7_Human1.06859738
96* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04729762
97CTCF_21964334_Chip-Seq_Bcells_Human1.04040754
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02956899
99* GATA1_19941826_ChIP-Seq_K562_Human1.02440942
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.00654730
101P300_27268052_Chip-Seq_Bcells_Human1.00079407
102* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99561101
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.99324585
104* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99015852
105PHF8_20622854_ChIP-Seq_HELA_Human0.98280858
106SPI1_20517297_ChIP-Seq_HL60_Human0.98186728
107E2F1_20622854_ChIP-Seq_HELA_Human0.97427517
108* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96549244
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96220392
110GATA3_27048872_Chip-Seq_THYMUS_Human0.95376092
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95251880
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94734802
113XRN2_22483619_ChIP-Seq_HELA_Human0.93993062
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92853166
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91861455
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86492388
117EST1_17652178_ChIP-ChIP_JURKAT_Human0.82780926
118CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81768452
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81411005
120* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81370589
121* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81062355
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81058698
123GATA3_26560356_Chip-Seq_TH2_Human0.80201282
124* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79324099
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78937598
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.78838780
127BCL6_27268052_Chip-Seq_Bcells_Human0.78719408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.31934550
2MP0002396_abnormal_hematopoietic_system3.58901049
3MP0005174_abnormal_tail_pigmentation3.24744260
4MP0005671_abnormal_response_to2.80127531
5MP0004808_abnormal_hematopoietic_stem2.75476928
6MP0005397_hematopoietic_system_phenotyp2.67881095
7MP0001545_abnormal_hematopoietic_system2.67881095
8MP0000685_abnormal_immune_system2.66881202
9MP0009379_abnormal_foot_pigmentation2.51475437
10MP0004510_myositis2.46948096
11MP0006292_abnormal_olfactory_placode2.40850873
12MP0000465_gastrointestinal_hemorrhage2.39563513
13MP0005075_abnormal_melanosome_morpholog2.37757249
14MP0009785_altered_susceptibility_to2.36573098
15MP0004147_increased_porphyrin_level2.35789073
16MP0001800_abnormal_humoral_immune2.34264591
17MP0000015_abnormal_ear_pigmentation2.29324354
18* MP0002398_abnormal_bone_marrow2.28298086
19MP0005464_abnormal_platelet_physiology2.23390500
20MP0002148_abnormal_hypersensitivity_rea2.22131238
21MP0002452_abnormal_antigen_presenting2.19412884
22MP0005025_abnormal_response_to2.16195063
23MP0001819_abnormal_immune_cell2.15177288
24MP0002420_abnormal_adaptive_immunity2.14919076
25MP0002095_abnormal_skin_pigmentation2.13280914
26MP0005387_immune_system_phenotype2.12983689
27MP0001790_abnormal_immune_system2.12983689
28MP0002723_abnormal_immune_serum2.09148918
29MP0003763_abnormal_thymus_physiology2.07958318
30MP0005000_abnormal_immune_tolerance1.94104998
31MP0000490_abnormal_crypts_of1.93030745
32* MP0000716_abnormal_immune_system1.91816964
33MP0009278_abnormal_bone_marrow1.87864555
34MP0002419_abnormal_innate_immunity1.87475950
35MP0002166_altered_tumor_susceptibility1.87394022
36MP0003303_peritoneal_inflammation1.86625078
37MP0001873_stomach_inflammation1.86085272
38MP0003724_increased_susceptibility_to1.84405181
39MP0005451_abnormal_body_composition1.80899501
40* MP0000689_abnormal_spleen_morphology1.73792373
41* MP0002429_abnormal_blood_cell1.71568494
42* MP0002722_abnormal_immune_system1.68214347
43MP0003436_decreased_susceptibility_to1.65501016
44MP0005409_darkened_coat_color1.59956947
45MP0001986_abnormal_taste_sensitivity1.58271855
46MP0001188_hyperpigmentation1.53402978
47MP0002877_abnormal_melanocyte_morpholog1.52661777
48MP0006054_spinal_hemorrhage1.50824038
49MP0000703_abnormal_thymus_morphology1.47805133
50MP0010155_abnormal_intestine_physiology1.47527235
51MP0003866_abnormal_defecation1.46714944
52MP0001853_heart_inflammation1.42226388
53MP0008260_abnormal_autophagy1.41854781
54MP0003693_abnormal_embryo_hatching1.38897162
55MP0005310_abnormal_salivary_gland1.37532410
56MP0001879_abnormal_lymphatic_vessel1.34421009
57MP0009333_abnormal_splenocyte_physiolog1.33843383
58MP0008995_early_reproductive_senescence1.32960193
59MP0002405_respiratory_system_inflammati1.32395524
60MP0004381_abnormal_hair_follicle1.31105898
61MP0010368_abnormal_lymphatic_system1.28477010
62MP0004947_skin_inflammation1.28121638
63MP0003191_abnormal_cellular_cholesterol1.27697993
64MP0003787_abnormal_imprinting1.25738333
65MP0002006_tumorigenesis1.25264922
66MP0003943_abnormal_hepatobiliary_system1.24954619
67MP0001845_abnormal_inflammatory_respons1.16241089
68MP0003828_pulmonary_edema1.15658047
69MP0002138_abnormal_hepatobiliary_system1.13668013
70MP0010094_abnormal_chromosome_stability1.07380573
71MP0002638_abnormal_pupillary_reflex1.05943329
72MP0005083_abnormal_biliary_tract1.05239804
73MP0000681_abnormal_thyroid_gland1.01902174
74MP0002693_abnormal_pancreas_physiology1.01268734
75MP0000569_abnormal_digit_pigmentation1.01055118
76MP0008058_abnormal_DNA_repair0.99896059
77MP0001663_abnormal_digestive_system0.98598905
78MP0008007_abnormal_cellular_replicative0.96480903
79MP0009764_decreased_sensitivity_to0.95625065
80MP0002876_abnormal_thyroid_physiology0.91872802
81MP0008469_abnormal_protein_level0.91340552
82MP0003183_abnormal_peptide_metabolism0.91186405
83MP0005058_abnormal_lysosome_morphology0.89067814
84MP0003806_abnormal_nucleotide_metabolis0.87687288
85MP0006082_CNS_inflammation0.86228129
86MP0002822_catalepsy0.85772538
87MP0005379_endocrine/exocrine_gland_phen0.84017423
88MP0000313_abnormal_cell_death0.83258782
89MP0006036_abnormal_mitochondrial_physio0.82741646
90MP0002132_abnormal_respiratory_system0.82622587
91MP0005535_abnormal_body_temperature0.82597740
92MP0005645_abnormal_hypothalamus_physiol0.82242792
93MP0001851_eye_inflammation0.80073823
94MP0003300_gastrointestinal_ulcer0.79529955
95MP0008057_abnormal_DNA_replication0.78773400
96MP0001944_abnormal_pancreas_morphology0.78684159
97MP0002019_abnormal_tumor_incidence0.78285501
98MP0005220_abnormal_exocrine_pancreas0.78038257
99MP0003656_abnormal_erythrocyte_physiolo0.75736541
100MP0008874_decreased_physiological_sensi0.75215938
101MP0005084_abnormal_gallbladder_morpholo0.74028050
102MP0002163_abnormal_gland_morphology0.73059260
103MP0008004_abnormal_stomach_pH0.72326805
104MP0003077_abnormal_cell_cycle0.72260603
105MP0009765_abnormal_xenobiotic_induced0.70239603
106MP0005076_abnormal_cell_differentiation0.69934086
107MP0000678_abnormal_parathyroid_gland0.69489456
108MP0000372_irregular_coat_pigmentation0.69278367
109MP0002009_preneoplasia0.67560969
110MP0003075_altered_response_to0.67118076
111MP0000371_diluted_coat_color0.65312705
112MP0003172_abnormal_lysosome_physiology0.64972338
113MP0003646_muscle_fatigue0.64451252
114MP0009763_increased_sensitivity_to0.62997681
115MP0003111_abnormal_nucleus_morphology0.61815844
116MP0009931_abnormal_skin_appearance0.61618989
117MP0000858_altered_metastatic_potential0.61524404
118MP0003868_abnormal_feces_composition0.61298723
119MP0001502_abnormal_circadian_rhythm0.59630370
120MP0002075_abnormal_coat/hair_pigmentati0.58972701
121MP0004185_abnormal_adipocyte_glucose0.57959257
122MP0008961_abnormal_basal_metabolism0.57729029
123MP0005666_abnormal_adipose_tissue0.57587423
124MP0002653_abnormal_ependyma_morphology0.54489122
125MP0002933_joint_inflammation0.54411083
126MP0005334_abnormal_fat_pad0.53804077
127MP0001533_abnormal_skeleton_physiology0.53372352
128MP0009115_abnormal_fat_cell0.52357983
129MP0002083_premature_death0.49837399
130MP0005166_decreased_susceptibility_to0.49467312
131MP0000609_abnormal_liver_physiology0.49244056
132MP0004145_abnormal_muscle_electrophysio0.47702580
133MP0005381_digestive/alimentary_phenotyp0.46807792

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.75681482
2Thrombocytosis (HP:0001894)4.98679528
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.60388384
4Petechiae (HP:0000967)4.53906890
5Prolonged bleeding time (HP:0003010)4.42271615
6Agammaglobulinemia (HP:0004432)4.26523845
7Aplastic anemia (HP:0001915)4.16660658
8Panhypogammaglobulinemia (HP:0003139)4.10396166
9Abnormality of macrophages (HP:0004311)3.82158937
10IgM deficiency (HP:0002850)3.62075161
11Increased IgE level (HP:0003212)3.61372592
12Abnormal number of erythroid precursors (HP:0012131)3.58901068
13Stomatitis (HP:0010280)3.56646717
14Reticulocytopenia (HP:0001896)3.50389024
15Recurrent viral infections (HP:0004429)3.47126980
16Abnormality of cells of the erythroid lineage (HP:0012130)3.43115304
17Cellulitis (HP:0100658)3.39359767
18Recurrent bacterial skin infections (HP:0005406)3.38277804
19Recurrent abscess formation (HP:0002722)3.36771277
20Cerebral palsy (HP:0100021)3.24828558
21Orchitis (HP:0100796)3.22355453
22Recurrent gram-negative bacterial infections (HP:0005420)3.22354772
23Chronic otitis media (HP:0000389)3.16014112
24Hypertensive crisis (HP:0100735)3.15899100
25Meningitis (HP:0001287)3.14647090
26Epistaxis (HP:0000421)3.12363668
27Recurrent cutaneous fungal infections (HP:0011370)3.11969924
28Chronic mucocutaneous candidiasis (HP:0002728)3.11969924
29Recurrent fungal infections (HP:0002841)3.10283077
30Urticaria (HP:0001025)3.04165909
31Inflammation of the large intestine (HP:0002037)3.03588655
32Gastrointestinal inflammation (HP:0004386)3.01890200
33Colitis (HP:0002583)3.00577088
34Abnormal platelet function (HP:0011869)2.99847901
35Impaired platelet aggregation (HP:0003540)2.99847901
36Abnormality of the fingertips (HP:0001211)2.99840285
37Gastrointestinal stroma tumor (HP:0100723)2.96962266
38Spontaneous hematomas (HP:0007420)2.93002000
39Retrobulbar optic neuritis (HP:0100654)2.90383797
40Optic neuritis (HP:0100653)2.90383797
41Acute lymphatic leukemia (HP:0006721)2.88375274
42Abnormality of T cell physiology (HP:0011840)2.84565030
43Elevated erythrocyte sedimentation rate (HP:0003565)2.80940183
44Osteomyelitis (HP:0002754)2.76978893
45Gastrointestinal infarctions (HP:0005244)2.75662497
46Granulocytopenia (HP:0001913)2.75620597
47Hypochromic anemia (HP:0001931)2.71734343
48Type 2 muscle fiber atrophy (HP:0003554)2.68813481
49Type I transferrin isoform profile (HP:0003642)2.65336170
50Spinal cord lesions (HP:0100561)2.64595656
51Syringomyelia (HP:0003396)2.64595656
52Broad face (HP:0000283)2.59797480
53Tented upper lip vermilion (HP:0010804)2.59580989
54Hypochromic microcytic anemia (HP:0004840)2.59168194
55Recurrent skin infections (HP:0001581)2.57883041
56Sepsis (HP:0100806)2.57081718
57Large eyes (HP:0001090)2.55558590
58Myositis (HP:0100614)2.55543946
59Reduced antithrombin III activity (HP:0001976)2.54383267
60Muscle fiber atrophy (HP:0100295)2.52235684
61Reticulocytosis (HP:0001923)2.50354570
62Pallor (HP:0000980)2.49798188
63Myelodysplasia (HP:0002863)2.49148489
64B lymphocytopenia (HP:0010976)2.47951108
65Abnormality of B cell number (HP:0010975)2.47951108
66Recurrent bronchitis (HP:0002837)2.47438534
67Papilloma (HP:0012740)2.44767644
68Verrucae (HP:0200043)2.44767644
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.43812618
70Abnormal platelet volume (HP:0011876)2.41308489
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38782476
72Leukocytosis (HP:0001974)2.38427609
73Acute myeloid leukemia (HP:0004808)2.38423933
74Episodic fever (HP:0001954)2.37712485
75Recurrent sinusitis (HP:0011108)2.34846866
76Hyperthyroidism (HP:0000836)2.32511452
77Gingivitis (HP:0000230)2.32472223
78Thyroiditis (HP:0100646)2.32197429
79Abnormality of the nasal mucosa (HP:0000433)2.31747016
80Increased serum ferritin (HP:0003281)2.30143938
81Chest pain (HP:0100749)2.29137088
82Keratoconjunctivitis sicca (HP:0001097)2.26448695
83Increased IgM level (HP:0003496)2.25059559
84Seborrheic dermatitis (HP:0001051)2.24758044
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23776736
86Neutropenia (HP:0001875)2.23657972
87Abnormality of iron homeostasis (HP:0011031)2.23251175
88Microcytic anemia (HP:0001935)2.23079572
89Skin rash (HP:0000988)2.22971892
90Encephalitis (HP:0002383)2.20803756
91Abnormality of T cells (HP:0002843)2.20731125
92Fatigue (HP:0012378)2.20723209
93Abnormality of DNA repair (HP:0003254)2.19269757
94Pulmonary fibrosis (HP:0002206)2.18162607
95Optic nerve coloboma (HP:0000588)2.17284083
96Hyperacusis (HP:0010780)2.16224818
97Gingival bleeding (HP:0000225)2.07835612
98Polycythemia (HP:0001901)2.07589446
99Obstructive lung disease (HP:0006536)2.07492986
100Chronic obstructive pulmonary disease (HP:0006510)2.07492986
101Viral hepatitis (HP:0006562)2.05571473
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05551498
103Exertional dyspnea (HP:0002875)2.04096134
104Albinism (HP:0001022)2.04028400
105Hypergammaglobulinemia (HP:0010702)2.03470167
106Amaurosis fugax (HP:0100576)2.03442638
107Hemoptysis (HP:0002105)2.03177226
108Purpura (HP:0000979)2.03032682
109Chromsome breakage (HP:0040012)2.02895352
110Clubbing of toes (HP:0100760)2.02845905
111Mediastinal lymphadenopathy (HP:0100721)2.02394991
112Hypoproteinemia (HP:0003075)2.02206952
113Pulmonary embolism (HP:0002204)2.01648172
114Pulmonary infiltrates (HP:0002113)2.01397740
115Skin ulcer (HP:0200042)1.99669490
11611 pairs of ribs (HP:0000878)1.99181852
117Keratoconjunctivitis (HP:0001096)1.99072101
118Nasal polyposis (HP:0100582)1.95118692
119Abnormality of the pleura (HP:0002103)1.93001261
120Abnormality of the columella (HP:0009929)1.92997591
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.92557347
122Autoimmune hemolytic anemia (HP:0001890)1.92386018
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92031635
124Abnormal protein N-linked glycosylation (HP:0012347)1.92031635
125Abnormal protein glycosylation (HP:0012346)1.92031635
126Abnormal glycosylation (HP:0012345)1.92031635
127Hepatosplenomegaly (HP:0001433)1.91863613
128Vasculitis (HP:0002633)1.91845617
129Vertigo (HP:0002321)1.91584740
130Menorrhagia (HP:0000132)1.90317077
131Lymphopenia (HP:0001888)1.90048174
132Truncus arteriosus (HP:0001660)1.90032920
133Abnormality of the thoracic spine (HP:0100711)1.89284597
134Abnormal gallbladder physiology (HP:0012438)1.89048774
135Cholecystitis (HP:0001082)1.89048774
136Volvulus (HP:0002580)1.88674839
137Arterial thrombosis (HP:0004420)1.88575580
138Slow saccadic eye movements (HP:0000514)1.88270204
139Visual hallucinations (HP:0002367)1.86529654
140Eczematoid dermatitis (HP:0000976)1.85303488
141Abnormality of the prostate (HP:0008775)1.84665092
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.82632371
143Hypothermia (HP:0002045)1.82513734
144Easy fatigability (HP:0003388)1.81117212
145IgG deficiency (HP:0004315)1.79785674
146Recurrent lower respiratory tract infections (HP:0002783)1.76537726
147Lymphoma (HP:0002665)1.76042799
148Synophrys (HP:0000664)1.73512872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.50488258
2ERN13.43445191
3MAP4K13.20297193
4IRAK42.86962294
5TAOK32.84631929
6TIE12.31329693
7TNIK2.13993206
8TRIB32.09545997
9GRK62.06697268
10BTK2.02944342
11JAK31.99738016
12MUSK1.98928034
13FES1.86853368
14TGFBR11.83910622
15MAP2K71.78098721
16EEF2K1.77322968
17MAP3K111.76987259
18SYK1.74158272
19TEC1.72262853
20FLT31.71473791
21CSF1R1.69918418
22TBK11.64343480
23TYK21.58926234
24MAP3K141.55404332
25SIK21.54742300
26STK161.53024854
27BLK1.52225642
28TGFBR21.46181574
29MKNK21.45255940
30SCYL21.45189689
31MATK1.44070957
32IKBKE1.43803513
33MAP3K61.42701311
34TESK21.41905849
35PIM21.41463802
36RIPK41.38712962
37MAP3K11.34966428
38SMG11.34470678
39IKBKB1.32288289
40PIM11.32252468
41NME21.30063893
42SRPK11.28470613
43ZAP701.28177792
44MARK21.26498521
45TNK21.25384803
46DYRK31.23952623
47IRAK31.20385951
48MAP2K31.18677322
49MAP3K121.17047634
50MAPK121.16213668
51SIK31.15319127
52CHUK1.14984226
53CDK121.14309871
54TAOK11.13869049
55CDK191.13816835
56VRK11.06916630
57CDK81.06084290
58MKNK11.05643578
59KDR0.96978954
60BRD40.95556828
61LRRK20.93678156
62PRKD20.93129794
63HIPK20.91797283
64LYN0.91707536
65CLK10.91621975
66MAP2K20.91536512
67TXK0.89976999
68MAP3K100.89120450
69RPS6KA60.86221622
70PDK10.86029359
71MARK30.85830388
72SIK10.84642756
73ITK0.84002224
74RPS6KB20.81516494
75CAMK10.81110510
76PKN20.79458103
77KSR20.75600064
78YES10.74686467
79RPS6KL10.72920593
80RPS6KC10.72920593
81MAPK40.72207334
82PDPK10.70897867
83RPS6KA20.69412593
84CDK40.68946458
85LCK0.67819144
86HCK0.67506061
87MAP2K60.67231409
88TAOK20.66159182
89PRKCQ0.64855864
90DAPK10.63245169
91ATR0.62830495
92BCKDK0.62673259
93RAF10.62480924
94NLK0.61537983
95MYLK0.61235689
96ACVR1B0.60853241
97PASK0.59427702
98CCNB10.59109968
99MAP2K40.58947093
100IRAK20.58414848
101MAPK130.56781931
102CDK90.54808614
103MAPKAPK50.53611112
104MAP3K70.53289666
105DAPK20.52533982
106MAPK70.51303821
107CAMKK10.50364094
108MAP3K30.49548544
109SGK20.49402772
110RET0.49147730
111MAP3K130.48000132
112MAPK30.47405864
113STK100.47240849
114JAK10.46663907
115PTK60.46174098
116CDC42BPA0.45876886
117CAMKK20.44869827
118FYN0.44544883
119EPHB10.44517088
120RPS6KA40.44030758
121FGFR30.43986861
122JAK20.43286485
123CDK70.43199707
124MAPK110.42756342
125ICK0.42191761
126FGR0.41897555
127ZAK0.41630474
128BMPR1B0.40322641
129RPS6KA50.39973071
130BMPR20.39524365
131BRSK20.39512296
132IRAK10.39333373
133DYRK1B0.39280055
134RPS6KB10.38555722
135STK40.37736557
136ALK0.37197424
137PRPF4B0.36861825
138CSK0.35502791
139PRKD10.34347734
140PIK3CG0.33233316

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.31483605
2Primary immunodeficiency_Homo sapiens_hsa053402.56284197
3Graft-versus-host disease_Homo sapiens_hsa053322.52287259
4DNA replication_Homo sapiens_hsa030302.28978718
5B cell receptor signaling pathway_Homo sapiens_hsa046622.26133238
6Staphylococcus aureus infection_Homo sapiens_hsa051502.07727302
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05344444
8Leishmaniasis_Homo sapiens_hsa051402.01614895
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80220640
10Measles_Homo sapiens_hsa051621.74348059
11Base excision repair_Homo sapiens_hsa034101.72679701
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.69428474
13Herpes simplex infection_Homo sapiens_hsa051681.68074123
14Mismatch repair_Homo sapiens_hsa034301.59659009
15Antigen processing and presentation_Homo sapiens_hsa046121.58588781
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57772455
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.57441577
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.56105860
19Hematopoietic cell lineage_Homo sapiens_hsa046401.55916183
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54271568
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53472623
22Acute myeloid leukemia_Homo sapiens_hsa052211.53126633
23Osteoclast differentiation_Homo sapiens_hsa043801.50937446
24Spliceosome_Homo sapiens_hsa030401.49133223
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.47076435
26Platelet activation_Homo sapiens_hsa046111.44023958
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40277814
28Homologous recombination_Homo sapiens_hsa034401.36234708
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30961002
30Influenza A_Homo sapiens_hsa051641.28260420
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26943106
32Other glycan degradation_Homo sapiens_hsa005111.26705176
33RNA degradation_Homo sapiens_hsa030181.23569123
34Protein export_Homo sapiens_hsa030601.20794943
35Fanconi anemia pathway_Homo sapiens_hsa034601.18189033
36Hepatitis B_Homo sapiens_hsa051611.16145982
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15507687
38Pertussis_Homo sapiens_hsa051331.14049720
39Non-homologous end-joining_Homo sapiens_hsa034501.13958507
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13187259
41Toxoplasmosis_Homo sapiens_hsa051451.12701942
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.10855135
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07846821
44Chemokine signaling pathway_Homo sapiens_hsa040621.06033914
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.04746387
46Apoptosis_Homo sapiens_hsa042101.04527436
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01828748
48Shigellosis_Homo sapiens_hsa051311.01621964
49N-Glycan biosynthesis_Homo sapiens_hsa005100.99645919
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99325630
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97399969
52Allograft rejection_Homo sapiens_hsa053300.96261334
53Tuberculosis_Homo sapiens_hsa051520.94974210
54Pyrimidine metabolism_Homo sapiens_hsa002400.94051704
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92869367
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.92026332
57Chronic myeloid leukemia_Homo sapiens_hsa052200.90905736
58Nucleotide excision repair_Homo sapiens_hsa034200.89616864
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87783938
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86750578
61mTOR signaling pathway_Homo sapiens_hsa041500.85803310
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85179500
63Prolactin signaling pathway_Homo sapiens_hsa049170.85070067
64TNF signaling pathway_Homo sapiens_hsa046680.84256651
65Rheumatoid arthritis_Homo sapiens_hsa053230.84034224
66Notch signaling pathway_Homo sapiens_hsa043300.84002374
67Phagosome_Homo sapiens_hsa041450.81595221
68Cell cycle_Homo sapiens_hsa041100.78970880
69Asthma_Homo sapiens_hsa053100.77006894
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75706836
71RNA polymerase_Homo sapiens_hsa030200.72920432
72Renal cell carcinoma_Homo sapiens_hsa052110.72220864
73Endometrial cancer_Homo sapiens_hsa052130.71713092
74Epstein-Barr virus infection_Homo sapiens_hsa051690.71490885
75Non-small cell lung cancer_Homo sapiens_hsa052230.70084904
76Inositol phosphate metabolism_Homo sapiens_hsa005620.69155148
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.68594028
78Choline metabolism in cancer_Homo sapiens_hsa052310.65123028
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.62974490
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62329758
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62243525
82Colorectal cancer_Homo sapiens_hsa052100.61088228
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61079467
84Purine metabolism_Homo sapiens_hsa002300.60750621
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60710559
86Salmonella infection_Homo sapiens_hsa051320.60537633
87ErbB signaling pathway_Homo sapiens_hsa040120.59116033
88p53 signaling pathway_Homo sapiens_hsa041150.58527196
89T cell receptor signaling pathway_Homo sapiens_hsa046600.57488525
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56564714
91Pancreatic cancer_Homo sapiens_hsa052120.55013798
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.54295593
93Malaria_Homo sapiens_hsa051440.54224864
94Pentose phosphate pathway_Homo sapiens_hsa000300.54151914
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53981877
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53569726
97HTLV-I infection_Homo sapiens_hsa051660.53167088
98Dorso-ventral axis formation_Homo sapiens_hsa043200.53103534
99African trypanosomiasis_Homo sapiens_hsa051430.52953331
100Type II diabetes mellitus_Homo sapiens_hsa049300.52413218
101Viral carcinogenesis_Homo sapiens_hsa052030.51408083
102Type I diabetes mellitus_Homo sapiens_hsa049400.50344418
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50144723
104Long-term potentiation_Homo sapiens_hsa047200.49763527
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49553801
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.49363715
107Endocytosis_Homo sapiens_hsa041440.47759569
108Legionellosis_Homo sapiens_hsa051340.47300322
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.46941772
110Small cell lung cancer_Homo sapiens_hsa052220.45756680
111GnRH signaling pathway_Homo sapiens_hsa049120.45740198
112Hepatitis C_Homo sapiens_hsa051600.45346362
113Circadian entrainment_Homo sapiens_hsa047130.44908985
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44633909
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43639791
116Viral myocarditis_Homo sapiens_hsa054160.43280472
117Basal transcription factors_Homo sapiens_hsa030220.42309962
118Regulation of autophagy_Homo sapiens_hsa041400.41435659
119Alcoholism_Homo sapiens_hsa050340.41349233
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41120982
121Autoimmune thyroid disease_Homo sapiens_hsa053200.39631207
122Insulin resistance_Homo sapiens_hsa049310.39570018
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39562144
124FoxO signaling pathway_Homo sapiens_hsa040680.39398722
125Insulin signaling pathway_Homo sapiens_hsa049100.39349825
126Glioma_Homo sapiens_hsa052140.39147203
127HIF-1 signaling pathway_Homo sapiens_hsa040660.37653576
128Morphine addiction_Homo sapiens_hsa050320.37633527
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37151157
130Circadian rhythm_Homo sapiens_hsa047100.35779649
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34259970
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34256771
133MAPK signaling pathway_Homo sapiens_hsa040100.34083430
134VEGF signaling pathway_Homo sapiens_hsa043700.32472760
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31304977

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