CBFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.03477963
2positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.03477963
3positive regulation of mitotic sister chromatid separation (GO:1901970)5.03477963
4DNA unwinding involved in DNA replication (GO:0006268)3.96823093
5viral mRNA export from host cell nucleus (GO:0046784)3.80438367
6ribosome assembly (GO:0042255)3.80044363
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70882378
8positive regulation of chromosome segregation (GO:0051984)3.68832196
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64014218
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50853668
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50853668
12positive regulation of gamma-delta T cell activation (GO:0046645)3.44532513
13nuclear pore complex assembly (GO:0051292)3.38094494
14viral transcription (GO:0019083)3.30396339
15ribosomal small subunit assembly (GO:0000028)3.29201274
16regulation of protein heterodimerization activity (GO:0043497)3.28149120
17translational termination (GO:0006415)3.23245510
18mitotic sister chromatid segregation (GO:0000070)3.20655215
19antigen processing and presentation of endogenous antigen (GO:0019883)3.14543373
20mitotic sister chromatid cohesion (GO:0007064)3.13727330
21nuclear pore organization (GO:0006999)3.12648727
22response to xenobiotic stimulus (GO:0009410)3.08860996
23mitotic metaphase plate congression (GO:0007080)3.03637406
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03165351
25regulation of mitotic spindle organization (GO:0060236)3.01140183
26translational elongation (GO:0006414)2.86314861
27protein localization to kinetochore (GO:0034501)2.86238946
28regulation of gamma-delta T cell differentiation (GO:0045586)2.81166700
29positive regulation of granulocyte differentiation (GO:0030854)2.79922390
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79783830
31positive regulation of B cell differentiation (GO:0045579)2.77031937
32DNA strand elongation involved in DNA replication (GO:0006271)2.74566014
33regulation of DNA damage checkpoint (GO:2000001)2.74061672
34establishment of chromosome localization (GO:0051303)2.73986286
35germ cell migration (GO:0008354)2.70528548
36translesion synthesis (GO:0019985)2.70337280
37negative regulation of RNA splicing (GO:0033119)2.69158336
38pore complex assembly (GO:0046931)2.68840300
39response to arsenic-containing substance (GO:0046685)2.68616818
40DNA topological change (GO:0006265)2.68034705
41negative regulation of phagocytosis (GO:0050765)2.64869243
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64613639
43dosage compensation (GO:0007549)2.64374994
44DNA duplex unwinding (GO:0032508)2.63865186
45RNA stabilization (GO:0043489)2.62946722
46mRNA stabilization (GO:0048255)2.62946722
47mitotic chromosome condensation (GO:0007076)2.61874213
48metaphase plate congression (GO:0051310)2.61871152
49DNA geometric change (GO:0032392)2.61605380
50translational initiation (GO:0006413)2.61085042
51mitochondrial DNA replication (GO:0006264)2.60530734
52regulation of B cell differentiation (GO:0045577)2.60106928
53attachment of spindle microtubules to kinetochore (GO:0008608)2.58486341
54mitotic nuclear envelope disassembly (GO:0007077)2.58455605
55sister chromatid cohesion (GO:0007062)2.58074947
56response to interleukin-15 (GO:0070672)2.57699714
57protein targeting to ER (GO:0045047)2.57053062
58T cell apoptotic process (GO:0070231)2.56391893
59DNA strand elongation (GO:0022616)2.56028615
60positive regulation of histone H3-K4 methylation (GO:0051571)2.55565382
61telomere maintenance via semi-conservative replication (GO:0032201)2.55003347
62viral life cycle (GO:0019058)2.54708869
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54635947
64hepatocyte apoptotic process (GO:0097284)2.54447581
65cotranslational protein targeting to membrane (GO:0006613)2.54378631
663-UTR-mediated mRNA stabilization (GO:0070935)2.53208868
67necroptotic process (GO:0070266)2.52814313
68mitotic recombination (GO:0006312)2.52472857
69regulation of RNA export from nucleus (GO:0046831)2.52463607
70IMP metabolic process (GO:0046040)2.51480691
71B cell proliferation (GO:0042100)2.50686822
72kinetochore organization (GO:0051383)2.50510593
73alternative mRNA splicing, via spliceosome (GO:0000380)2.48873507
74establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48374175
75nuclear envelope disassembly (GO:0051081)2.47746313
76membrane disassembly (GO:0030397)2.47746313
77isotype switching (GO:0045190)2.46559149
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.46559149
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.46559149
80regulation of gamma-delta T cell activation (GO:0046643)2.46326270
81non-recombinational repair (GO:0000726)2.45670895
82double-strand break repair via nonhomologous end joining (GO:0006303)2.45670895
83nuclear envelope organization (GO:0006998)2.45105255
84DNA double-strand break processing (GO:0000729)2.43660980
85cellular response to interleukin-15 (GO:0071350)2.43184694
86leukocyte aggregation (GO:0070486)2.42411753
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42317928
88telomere maintenance via recombination (GO:0000722)2.42234779
89IMP biosynthetic process (GO:0006188)2.42178774
90cellular protein complex disassembly (GO:0043624)2.42053932
91protein localization to chromosome, centromeric region (GO:0071459)2.41699363
92COPII vesicle coating (GO:0048208)2.41617586
93regulation of sister chromatid cohesion (GO:0007063)2.41386981
94microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.40871713
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40727931
96glucocorticoid receptor signaling pathway (GO:0042921)2.40482727
97regulation of sister chromatid segregation (GO:0033045)2.39852795
98regulation of mitotic sister chromatid separation (GO:0010965)2.39852795
99regulation of mitotic sister chromatid segregation (GO:0033047)2.39852795
100proteasome assembly (GO:0043248)2.39121537
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37939277
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.37939277
103regulation of thymocyte apoptotic process (GO:0070243)2.37790343
104rRNA methylation (GO:0031167)2.37606255
105natural killer cell differentiation (GO:0001779)2.37390512
106ER overload response (GO:0006983)2.37283909
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.36877393
108positive thymic T cell selection (GO:0045059)2.35348830
109positive regulation of lamellipodium assembly (GO:0010592)2.34911601
110regulation of chromosome segregation (GO:0051983)2.34165833
111nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.33807825
112protein localization to endoplasmic reticulum (GO:0070972)2.33293167
113lymphocyte apoptotic process (GO:0070227)2.32815988
114histamine secretion (GO:0001821)2.32482895
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.32279670
116negative T cell selection (GO:0043383)2.31580392
117protein K6-linked ubiquitination (GO:0085020)2.31492285
118maturation of SSU-rRNA (GO:0030490)2.29988830
119sister chromatid segregation (GO:0000819)2.29959773
120positive regulation of alpha-beta T cell proliferation (GO:0046641)2.29727468
121lactate metabolic process (GO:0006089)2.28554750
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.28149954
123protein complex disassembly (GO:0043241)2.27353837
124negative thymic T cell selection (GO:0045060)2.27026386
125corticosteroid receptor signaling pathway (GO:0031958)2.26278363
126ribosomal small subunit biogenesis (GO:0042274)2.24932034
127negative regulation of DNA repair (GO:0045738)2.24726848
128B cell receptor signaling pathway (GO:0050853)2.24150175
129megakaryocyte development (GO:0035855)2.24058209
130T cell homeostasis (GO:0043029)2.24024997
131DNA replication initiation (GO:0006270)2.23919958
132chromatin assembly (GO:0031497)2.23640202
133morphogenesis of an endothelium (GO:0003159)2.22215189
134endothelial tube morphogenesis (GO:0061154)2.22215189
135formation of translation preinitiation complex (GO:0001731)2.22062088
136chromosome condensation (GO:0030261)2.21338807
137interferon-gamma production (GO:0032609)2.21046693
138heterochromatin organization (GO:0070828)2.19385271
139spindle assembly involved in mitosis (GO:0090307)2.19128463
140negative regulation of thymocyte apoptotic process (GO:0070244)2.18501514
141nuclear-transcribed mRNA catabolic process (GO:0000956)2.18149234
142actin nucleation (GO:0045010)2.17973731
143regulation of B cell receptor signaling pathway (GO:0050855)2.17533462
144regulation of RIG-I signaling pathway (GO:0039535)2.16842221
145poly(A)+ mRNA export from nucleus (GO:0016973)2.16566260
146chromosome segregation (GO:0007059)2.16122421
147folic acid-containing compound biosynthetic process (GO:0009396)2.16005124
148* definitive hemopoiesis (GO:0060216)2.14937110
149ribosome biogenesis (GO:0042254)2.14727655
150somatic recombination of immunoglobulin gene segments (GO:0016447)2.13895457
151regulation of translational termination (GO:0006449)2.13400160
152regulation of mRNA stability (GO:0043488)2.13126670
153DNA packaging (GO:0006323)2.12938025
154protein localization to chromosome (GO:0034502)2.12817200
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.12720998
156histone mRNA catabolic process (GO:0071044)2.12441608
157positive regulation of histone deacetylation (GO:0031065)2.12272097
158regulation of histone H3-K9 methylation (GO:0051570)2.11059015
159regulation of spindle organization (GO:0090224)2.10198956
160postreplication repair (GO:0006301)2.09382585
161histone-serine phosphorylation (GO:0035404)2.09291750
162mRNA catabolic process (GO:0006402)2.09215137
163negative regulation of B cell proliferation (GO:0030889)2.08635541
164negative regulation of cell killing (GO:0031342)2.08284136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15474657
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.17206448
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.06885420
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84974414
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31961604
6* MYC_22102868_ChIP-Seq_BL_Human3.13444566
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98133253
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59632093
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47074539
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.46692603
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.37957273
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35368509
13VDR_21846776_ChIP-Seq_THP-1_Human2.31654969
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28324819
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24686428
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21173529
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18708012
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.11972842
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05394194
20MYB_26560356_Chip-Seq_TH2_Human1.95121881
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94802785
22MAF_26560356_Chip-Seq_TH1_Human1.94763551
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91813434
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.90069830
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85960822
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83330559
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.81597362
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.79157672
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79108659
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77297744
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74155757
32AR_21909140_ChIP-Seq_LNCAP_Human1.73963000
33TCF7_22412390_ChIP-Seq_EML_Mouse1.73679339
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72111172
35UTX_26944678_Chip-Seq_JUKART_Human1.69665879
36VDR_24763502_ChIP-Seq_THP-1_Human1.65752578
37MYB_26560356_Chip-Seq_TH1_Human1.65252782
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64603838
39SPI1_23547873_ChIP-Seq_NB4_Human1.63672953
40SCL_19346495_ChIP-Seq_HPC-7_Human1.62272466
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61757734
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61694796
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59852994
44* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58554507
45DCP1A_22483619_ChIP-Seq_HELA_Human1.57818662
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56961163
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.54531163
48ELK1_19687146_ChIP-ChIP_HELA_Human1.51685631
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.50557300
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48694483
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48656253
52* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48302699
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.47771441
54CIITA_25753668_ChIP-Seq_RAJI_Human1.45747971
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44351101
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44286637
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.43799820
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.42738817
59RUNX_20019798_ChIP-Seq_JUKART_Human1.41566227
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39929160
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.37545151
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36357058
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35994182
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34080694
65XRN2_22483619_ChIP-Seq_HELA_Human1.32865498
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32825911
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.31513377
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30799622
69* KDM2B_26808549_Chip-Seq_DND41_Human1.30760034
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26398951
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25303511
72GATA1_22025678_ChIP-Seq_K562_Human1.24966183
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23591204
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23288696
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22356400
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21942246
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21812824
78TFEB_21752829_ChIP-Seq_HELA_Human1.21768271
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18202251
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17720197
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.17120131
82VDR_23849224_ChIP-Seq_CD4+_Human1.16025063
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15028438
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13745647
85* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12802425
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12028599
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11386192
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10681431
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.10179366
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09937401
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08728625
92* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08006667
93* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07631882
94PU_27001747_Chip-Seq_BMDM_Mouse1.06837108
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05829293
96MAF_26560356_Chip-Seq_TH2_Human1.05598654
97CLOCK_20551151_ChIP-Seq_293T_Human1.04557223
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04181180
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03330641
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03010524
101GATA3_27048872_Chip-Seq_THYMUS_Human0.99660625
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99542630
103SPI1_23127762_ChIP-Seq_K562_Human0.98891645
104FOXP3_21729870_ChIP-Seq_TREG_Human0.98348555
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98286025
106* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97924671
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97876783
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97815487
109* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97709375
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.97577637
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97541099
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97459855
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96873156
114TTF2_22483619_ChIP-Seq_HELA_Human0.95094122
115* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94605141
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94264069
117* CHD1_26751641_Chip-Seq_LNCaP_Human0.94130359
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.94012381
119* NCOR1_26117541_ChIP-Seq_K562_Human0.93916364
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93340643
121CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93209454
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91667239
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91631406
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91631406
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91533020
126KDM5A_27292631_Chip-Seq_BREAST_Human0.91445702
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91319437
128ATF3_27146783_Chip-Seq_COLON_Human0.91291744
129GATA3_26560356_Chip-Seq_TH2_Human0.91225129
130* BRD4_25478319_ChIP-Seq_HGPS_Human0.89826045
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89386038
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87456109
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86738881
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86168821
135ETS1_20019798_ChIP-Seq_JURKAT_Human0.83302678
136* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81360031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps2.97978888
2MP0003300_gastrointestinal_ulcer2.54390161
3MP0002396_abnormal_hematopoietic_system2.44567316
4MP0003705_abnormal_hypodermis_morpholog2.39630871
5MP0010307_abnormal_tumor_latency2.29557592
6MP0002166_altered_tumor_susceptibility2.13541761
7MP0006054_spinal_hemorrhage2.10650776
8MP0001835_abnormal_antigen_presentation2.06541192
9MP0008438_abnormal_cutaneous_collagen2.05150355
10MP0003763_abnormal_thymus_physiology2.04664466
11* MP0004808_abnormal_hematopoietic_stem2.02094752
12MP0005076_abnormal_cell_differentiation2.01124541
13MP0009278_abnormal_bone_marrow1.92514326
14MP0000685_abnormal_immune_system1.91908842
15MP0003303_peritoneal_inflammation1.89270437
16MP0010094_abnormal_chromosome_stability1.84394107
17MP0003890_abnormal_embryonic-extraembry1.81404223
18MP0002006_tumorigenesis1.80834686
19MP0003693_abnormal_embryo_hatching1.74724980
20MP0004957_abnormal_blastocyst_morpholog1.68965654
21* MP0001800_abnormal_humoral_immune1.67759045
22MP0003077_abnormal_cell_cycle1.67214152
23* MP0002398_abnormal_bone_marrow1.63733849
24MP0003566_abnormal_cell_adhesion1.60727323
25MP0003806_abnormal_nucleotide_metabolis1.60289954
26* MP0002452_abnormal_antigen_presenting1.56555375
27MP0003436_decreased_susceptibility_to1.56173029
28MP0000733_abnormal_muscle_development1.55102980
29MP0008057_abnormal_DNA_replication1.54421655
30MP0005671_abnormal_response_to1.53752021
31MP0009697_abnormal_copulation1.53590160
32MP0000490_abnormal_crypts_of1.51591996
33MP0000465_gastrointestinal_hemorrhage1.49847378
34MP0005397_hematopoietic_system_phenotyp1.47860332
35MP0001545_abnormal_hematopoietic_system1.47860332
36* MP0002420_abnormal_adaptive_immunity1.47198141
37MP0009333_abnormal_splenocyte_physiolog1.46762836
38MP0008007_abnormal_cellular_replicative1.46094908
39MP0005000_abnormal_immune_tolerance1.46033968
40* MP0001819_abnormal_immune_cell1.44663024
41MP0005387_immune_system_phenotype1.41163900
42MP0001790_abnormal_immune_system1.41163900
43MP0003111_abnormal_nucleus_morphology1.39689431
44MP0010234_abnormal_vibrissa_follicle1.38807340
45* MP0000703_abnormal_thymus_morphology1.38373615
46* MP0002722_abnormal_immune_system1.36208578
47MP0005023_abnormal_wound_healing1.35444925
48* MP0002723_abnormal_immune_serum1.34977208
49MP0005310_abnormal_salivary_gland1.33893953
50MP0005275_abnormal_skin_tensile1.32370203
51* MP0000716_abnormal_immune_system1.32030349
52MP0004947_skin_inflammation1.29484933
53MP0000350_abnormal_cell_proliferation1.29220556
54* MP0000689_abnormal_spleen_morphology1.29039376
55MP0002877_abnormal_melanocyte_morpholog1.27467065
56* MP0002405_respiratory_system_inflammati1.24503248
57MP0010155_abnormal_intestine_physiology1.23783318
58MP0010678_abnormal_skin_adnexa1.21952208
59MP0000858_altered_metastatic_potential1.20058191
60MP0003786_premature_aging1.18741809
61* MP0002429_abnormal_blood_cell1.18701540
62MP0006082_CNS_inflammation1.18580821
63MP0003448_altered_tumor_morphology1.18137319
64MP0001873_stomach_inflammation1.18089046
65MP0003279_aneurysm1.17907500
66MP0002019_abnormal_tumor_incidence1.17896792
67MP0004197_abnormal_fetal_growth/weight/1.17570166
68MP0001730_embryonic_growth_arrest1.15066781
69MP0001879_abnormal_lymphatic_vessel1.13997084
70MP0002933_joint_inflammation1.13730307
71MP0008058_abnormal_DNA_repair1.11837553
72MP0005025_abnormal_response_to1.11292763
73MP0003567_abnormal_fetal_cardiomyocyte1.10327241
74MP0002419_abnormal_innate_immunity1.09792108
75MP0009785_altered_susceptibility_to1.09595017
76MP0002009_preneoplasia1.08498785
77MP0005464_abnormal_platelet_physiology1.07426730
78MP0002163_abnormal_gland_morphology1.06005578
79MP0003091_abnormal_cell_migration1.04444258
80MP0000015_abnormal_ear_pigmentation1.04236103
81MP0001853_heart_inflammation1.03870632
82MP0000013_abnormal_adipose_tissue1.03746200
83MP0002148_abnormal_hypersensitivity_rea1.03061592
84* MP0003943_abnormal_hepatobiliary_system1.01770715
85MP0005075_abnormal_melanosome_morpholog1.01752614
86* MP0002086_abnormal_extraembryonic_tissu0.98794519
87* MP0000313_abnormal_cell_death0.98397420
88MP0000569_abnormal_digit_pigmentation0.97720367
89MP0001697_abnormal_embryo_size0.97317913
90MP0008932_abnormal_embryonic_tissue0.96689575
91MP0005503_abnormal_tendon_morphology0.96634952
92MP0009053_abnormal_anal_canal0.94153486
93MP0001915_intracranial_hemorrhage0.93662018
94MP0003656_abnormal_erythrocyte_physiolo0.93077701
95MP0001533_abnormal_skeleton_physiology0.92877026
96MP0001661_extended_life_span0.92652864
97MP0002088_abnormal_embryonic_growth/wei0.90549652
98MP0003984_embryonic_growth_retardation0.90536129
99MP0000428_abnormal_craniofacial_morphol0.89194766
100MP0001216_abnormal_epidermal_layer0.87160238
101MP0005220_abnormal_exocrine_pancreas0.86937801
102MP0005380_embryogenesis_phenotype0.85827729
103MP0001672_abnormal_embryogenesis/_devel0.85827729
104MP0001727_abnormal_embryo_implantation0.85663991
105MP0003828_pulmonary_edema0.84978250
106* MP0002080_prenatal_lethality0.83930069
107MP0003453_abnormal_keratinocyte_physiol0.83850363
108MP0002084_abnormal_developmental_patter0.83451918
109MP0002060_abnormal_skin_morphology0.82863815
110MP0002269_muscular_atrophy0.81479609
111MP0003866_abnormal_defecation0.81323309
112MP0001845_abnormal_inflammatory_respons0.81290684
113MP0001958_emphysema0.80529481
114MP0000377_abnormal_hair_follicle0.80164379
115MP0005257_abnormal_intraocular_pressure0.80106563
116MP0002254_reproductive_system_inflammat0.80057784
117MP0000537_abnormal_urethra_morphology0.80018741
118MP0002925_abnormal_cardiovascular_devel0.79282230
119MP0002693_abnormal_pancreas_physiology0.79150334
120MP0004185_abnormal_adipocyte_glucose0.78974733
121MP0002085_abnormal_embryonic_tissue0.78269709
122MP0003123_paternal_imprinting0.78085112
123MP0001849_ear_inflammation0.78075157
124MP0005390_skeleton_phenotype0.77958393
125MP0006072_abnormal_retinal_apoptosis0.77619232
126MP0005058_abnormal_lysosome_morphology0.76397993
127MP0005408_hypopigmentation0.75279545
128MP0000358_abnormal_cell_content/0.75097696
129MP0005621_abnormal_cell_physiology0.73773979
130MP0000427_abnormal_hair_cycle0.73080810
131MP0000627_abnormal_mammary_gland0.71744833
132MP0005379_endocrine/exocrine_gland_phen0.71721607
133MP0001191_abnormal_skin_condition0.71543080
134MP0003172_abnormal_lysosome_physiology0.70318685
135MP0003724_increased_susceptibility_to0.69379499
136MP0001851_eye_inflammation0.68975151

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)3.81560206
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58592583
3Chromsome breakage (HP:0040012)3.37425935
4Abnormality of the pancreatic islet cells (HP:0006476)3.34088562
5Abnormality of endocrine pancreas physiology (HP:0012093)3.34088562
6Hyperinsulinemic hypoglycemia (HP:0000825)3.30422072
7Increased density of long bones (HP:0006392)3.30084465
8Stomatitis (HP:0010280)3.12559654
9Pancreatic islet-cell hyperplasia (HP:0004510)3.06928924
10Protrusio acetabuli (HP:0003179)3.04526993
11Abnormality of DNA repair (HP:0003254)3.01938550
12Combined immunodeficiency (HP:0005387)2.90464588
13Myelodysplasia (HP:0002863)2.78807903
14Abnormality of chromosome stability (HP:0003220)2.77057982
15Severe combined immunodeficiency (HP:0004430)2.76447517
16Short 4th metacarpal (HP:0010044)2.71171100
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71171100
18Ankyloglossia (HP:0010296)2.69836652
19Abnormality of oral frenula (HP:0000190)2.68318538
20Symptomatic seizures (HP:0011145)2.67939003
21* Acute myeloid leukemia (HP:0004808)2.67663185
22Thrombocytosis (HP:0001894)2.65537485
23Syringomyelia (HP:0003396)2.59349302
24Spinal cord lesions (HP:0100561)2.59349302
25Cellulitis (HP:0100658)2.58879297
26Subacute progressive viral hepatitis (HP:0006572)2.55528569
27Hematochezia (HP:0002573)2.55377592
28T lymphocytopenia (HP:0005403)2.54687796
29Recurrent viral infections (HP:0004429)2.50362922
30Hypoglycemic coma (HP:0001325)2.44339839
31Chronic mucocutaneous candidiasis (HP:0002728)2.43880078
32Recurrent cutaneous fungal infections (HP:0011370)2.43880078
33Abnormal foot bone ossification (HP:0010675)2.43572895
34Abnormality of the preputium (HP:0100587)2.41425544
35Abnormality of T cell number (HP:0011839)2.40171882
36Acute hepatic failure (HP:0006554)2.39132117
37Entropion (HP:0000621)2.37356926
38Fatigue (HP:0012378)2.36605432
39Cystic hygroma (HP:0000476)2.35884240
40IgM deficiency (HP:0002850)2.34095566
41Eczematoid dermatitis (HP:0000976)2.30519752
42Chronic diarrhea (HP:0002028)2.29814382
43Abnormality of the calcaneus (HP:0008364)2.26184343
44Osteolytic defects of the hand bones (HP:0009699)2.25992129
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.25992129
46Abnormality of chromosome segregation (HP:0002916)2.25228326
47Deep philtrum (HP:0002002)2.25016923
48Transitional cell carcinoma of the bladder (HP:0006740)2.25014629
49Cerebral aneurysm (HP:0004944)2.24775908
50Hyperglycemia (HP:0003074)2.23406907
51Metaphyseal dysplasia (HP:0100255)2.22882932
52Recurrent bronchitis (HP:0002837)2.21613371
53Ketoacidosis (HP:0001993)2.21529728
54Squamous cell carcinoma (HP:0002860)2.20645343
55Type I diabetes mellitus (HP:0100651)2.19672773
56Prominent metopic ridge (HP:0005487)2.19440517
57Ankle contracture (HP:0006466)2.18914948
58Autoimmune hemolytic anemia (HP:0001890)2.17236704
59Aortic aneurysm (HP:0004942)2.16541859
60Recurrent fungal infections (HP:0002841)2.12557734
61Bicuspid aortic valve (HP:0001647)2.12003765
62Bladder carcinoma (HP:0002862)2.11950052
63Bladder neoplasm (HP:0009725)2.11950052
64Poikiloderma (HP:0001029)2.09458987
65Thyroid carcinoma (HP:0002890)2.09170016
66Ulnar deviation of the wrist (HP:0003049)2.09072371
67Abnormality of T cells (HP:0002843)2.08997395
68Selective tooth agenesis (HP:0001592)2.06203548
69Spondylolisthesis (HP:0003302)2.06011638
70Elevated erythrocyte sedimentation rate (HP:0003565)2.05718588
71Deviation of the thumb (HP:0009603)2.04968537
72Myositis (HP:0100614)2.04372092
73Asymmetry of the thorax (HP:0001555)2.03195610
74Curly hair (HP:0002212)2.03160086
75Recurrent skin infections (HP:0001581)2.03156104
76Premature rupture of membranes (HP:0001788)2.02616488
77Overlapping toe (HP:0001845)2.02295520
78Aortic dissection (HP:0002647)2.01579966
79Cervical subluxation (HP:0003308)2.01516671
80Persistence of primary teeth (HP:0006335)2.01165509
81Cutaneous melanoma (HP:0012056)2.01082736
82Relative macrocephaly (HP:0004482)2.00043957
83Acute lymphatic leukemia (HP:0006721)1.99881965
84Clubbing of toes (HP:0100760)1.99691707
85Menstrual irregularities (HP:0000858)1.99587760
86Ulnar bowing (HP:0003031)1.98338594
87Mitral valve prolapse (HP:0001634)1.98058281
88Abnormality of the fingertips (HP:0001211)1.98012250
89Chronic otitis media (HP:0000389)1.96129425
90Embryonal renal neoplasm (HP:0011794)1.95762670
91Prominent nose (HP:0000448)1.95678247
92Abnormality of the peritoneum (HP:0002585)1.95388963
93Pustule (HP:0200039)1.94813991
94Proximal placement of thumb (HP:0009623)1.94599988
95Melanoma (HP:0002861)1.94388204
96Dilatation of the ascending aorta (HP:0005111)1.93529880
97Papilloma (HP:0012740)1.92729367
98Verrucae (HP:0200043)1.92729367
99Calcaneovalgus deformity (HP:0001848)1.92679418
100Reticulocytopenia (HP:0001896)1.90827475
101Rectal prolapse (HP:0002035)1.89911998
102Volvulus (HP:0002580)1.88706124
103Abnormality of the 4th metacarpal (HP:0010012)1.88224605
104Sandal gap (HP:0001852)1.86760608
105Colon cancer (HP:0003003)1.86536845
106Cafe-au-lait spot (HP:0000957)1.86192752
107Thoracolumbar scoliosis (HP:0002944)1.85557217
108Orthostatic hypotension (HP:0001278)1.84839652
109Shallow orbits (HP:0000586)1.84662702
110Exocrine pancreatic insufficiency (HP:0001738)1.84013073
111Abnormality of B cell number (HP:0010975)1.83185080
112B lymphocytopenia (HP:0010976)1.83185080
113IgG deficiency (HP:0004315)1.83005298
114High pitched voice (HP:0001620)1.82371585
115Abnormality of the prostate (HP:0008775)1.80773776
116Osteomyelitis (HP:0002754)1.79822549
117Bone marrow hypocellularity (HP:0005528)1.79794089
118Recurrent abscess formation (HP:0002722)1.79679603
119Papillary thyroid carcinoma (HP:0002895)1.79563631
120Spontaneous hematomas (HP:0007420)1.79484703
121Aplastic anemia (HP:0001915)1.78998343
122Hypergonadotropic hypogonadism (HP:0000815)1.78972705
123Viral hepatitis (HP:0006562)1.78844893
124Distal arthrogryposis (HP:0005684)1.77071301
125Short middle phalanx of the 5th finger (HP:0004220)1.76912730
126Slender build (HP:0001533)1.76475071
127Vacuolated lymphocytes (HP:0001922)1.76035631
128Genu recurvatum (HP:0002816)1.75058401
129Abnormality of T cell physiology (HP:0011840)1.74982955
130Duodenal stenosis (HP:0100867)1.74847973
131Small intestinal stenosis (HP:0012848)1.74847973
132Recurrent bacterial skin infections (HP:0005406)1.74679186
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.74436304
134Pancytopenia (HP:0001876)1.73989361
135Deformed tarsal bones (HP:0008119)1.73629604
136Peritonitis (HP:0002586)1.73249597
137Absent frontal sinuses (HP:0002688)1.71453813
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71205357
139Thyroiditis (HP:0100646)1.71205219
140Lower limb hyperreflexia (HP:0002395)1.71095583
141Abnormal platelet volume (HP:0011876)1.70934353
142Hallux valgus (HP:0001822)1.70516707
143Deviation of the hallux (HP:0010051)1.69964993
144Nephroblastoma (Wilms tumor) (HP:0002667)1.69497507
145Lymphedema (HP:0001004)1.68249963
146Radial bowing (HP:0002986)1.68006155
147Hyperacusis (HP:0010780)1.67949771
148Thin bony cortex (HP:0002753)1.67471297
149Micronodular cirrhosis (HP:0001413)1.67425830
150Increased nuchal translucency (HP:0010880)1.66539397
151Chest pain (HP:0100749)1.66507164
152Meningitis (HP:0001287)1.65638660
153Single umbilical artery (HP:0001195)1.65414980
154Abnormality of the fetal cardiovascular system (HP:0010948)1.65414980
155Abnormal umbilical cord blood vessels (HP:0011403)1.65414980
156Basal cell carcinoma (HP:0002671)1.65151754
157Arterial thrombosis (HP:0004420)1.64839737
158Mesomelia (HP:0003027)1.63751711
159Broad palm (HP:0001169)1.63281309
160Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63000519
161Mitral regurgitation (HP:0001653)1.62579897
162Type 1 muscle fiber predominance (HP:0003803)1.62009613
163Panhypogammaglobulinemia (HP:0003139)1.61618740
164Eosinophilia (HP:0001880)1.60845031
165Muscle fiber inclusion bodies (HP:0100299)1.58980914
166Delayed closure of the anterior fontanelle (HP:0001476)1.55793470
167Abnormality of cells of the lymphoid lineage (HP:0012140)1.55581527
168Bowel diverticulosis (HP:0005222)1.55126399
169Lymphopenia (HP:0001888)1.54777343
170Cutis marmorata (HP:0000965)1.54656598
171Long eyelashes (HP:0000527)1.54618920
172Lymphoma (HP:0002665)1.54274865
173IgA deficiency (HP:0002720)1.53971816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.14110683
2MAP4K13.00030631
3MAP3K102.95165902
4PKN22.79562584
5TRIB32.69754022
6CDC72.32371659
7TTN2.24514114
8STK102.19749316
9LRRK22.15864491
10SCYL21.94348260
11IRAK31.79862451
12NEK21.78332223
13TGFBR11.78045789
14JAK31.76671975
15RPS6KA41.71814686
16NEK91.67988262
17NUAK11.65848178
18MAP3K21.64984914
19ZAP701.54302052
20RPS6KB21.53248898
21CDK61.51608799
22CDK121.50848313
23EIF2AK21.50492229
24MAP2K31.47469875
25KSR21.46666667
26TTK1.41144564
27MAP3K131.39995539
28BTK1.38553817
29RAF11.37988863
30BMPR21.36722932
31NME21.35521930
32FGFR31.34630003
33PTK61.33987887
34TXK1.32955238
35PBK1.31909427
36YES11.30738310
37BLK1.30499718
38ITK1.28945238
39NEK11.27957999
40MAP3K81.26346923
41MAP3K121.26221418
42PLK41.23295353
43TYK21.20174039
44ERBB31.19145260
45STK31.18141368
46TAF11.17109175
47CDK41.16848026
48TRPM71.16769000
49FLT31.15816755
50PLK31.13884039
51PASK1.12765469
52CSF1R1.12361960
53IRAK11.12070392
54PIM11.11955063
55TGFBR21.11748292
56WEE11.10532431
57TEC1.10054757
58MKNK11.09700586
59KIT1.07600236
60ACVR1B1.05870505
61CSK1.05565281
62PIM21.01842009
63KSR10.99697492
64PDGFRA0.99257697
65PAK40.98409743
66TESK20.92567444
67EIF2AK10.91916050
68TBK10.91804939
69KDR0.91525537
70NLK0.90361033
71STK240.88690468
72SMG10.88666844
73CLK10.88646061
74ERBB40.85886814
75LCK0.85733590
76GRK60.85080249
77STK40.84908604
78EPHA30.84587896
79BRSK20.83892070
80AKT30.83665694
81IKBKB0.83522666
82HCK0.82851078
83PDGFRB0.81590529
84MAP4K20.81372687
85ALK0.81356960
86MAP3K10.80898453
87MST40.80626651
88PRPF4B0.79832572
89AURKB0.78300263
90SRPK10.76762555
91ERN10.74754514
92ATR0.73670261
93PAK20.73503562
94MARK30.71322787
95EIF2AK30.71192096
96ILK0.70960424
97DMPK0.70725426
98SYK0.70048887
99CDK70.69849896
100MOS0.69355093
101RIPK10.68284313
102CDK90.67961551
103FGFR40.67883846
104EPHB10.67831463
105JAK10.66320048
106MAPKAPK30.66260636
107DDR20.65896634
108MKNK20.64443579
109BRD40.64198310
110CHUK0.63642861
111MAPK110.63414250
112PNCK0.62641655
113TSSK60.62508418
114BMPR1B0.62218265
115DYRK30.61851949
116FGFR10.61285732
117MAP3K140.60802474
118MELK0.60561928
119STK390.60539172
120CHEK20.59446314
121FRK0.58694826
122LATS10.56762569
123DYRK1B0.56187158
124IRAK20.55988911
125BUB10.55935708
126CHEK10.55614607
127MTOR0.55545920
128TAOK30.55256337
129LYN0.54459657
130TESK10.53062339
131CDK80.51862343
132MATK0.51388102
133PLK10.51125096
134BMX0.50054972
135LIMK10.49510952
136MAP3K30.49505987
137HIPK20.49501485
138MAPKAPK20.47038142
139ATM0.46177982
140FGFR20.44743081
141TAOK20.43359834
142STK38L0.42208600
143STK160.41186980
144CDK30.40881899

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.64599139
2Mismatch repair_Homo sapiens_hsa034302.00183299
3Type I diabetes mellitus_Homo sapiens_hsa049401.93303460
4Primary immunodeficiency_Homo sapiens_hsa053401.91516398
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89189178
6Antigen processing and presentation_Homo sapiens_hsa046121.83239640
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.80662329
8Cell cycle_Homo sapiens_hsa041101.77799768
9Leishmaniasis_Homo sapiens_hsa051401.70875756
10Ribosome_Homo sapiens_hsa030101.68114161
11B cell receptor signaling pathway_Homo sapiens_hsa046621.67296919
12Chronic myeloid leukemia_Homo sapiens_hsa052201.67093937
13Viral myocarditis_Homo sapiens_hsa054161.57213096
14Small cell lung cancer_Homo sapiens_hsa052221.51196895
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.51147815
16Measles_Homo sapiens_hsa051621.50532343
17Spliceosome_Homo sapiens_hsa030401.50347772
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48204434
19Autoimmune thyroid disease_Homo sapiens_hsa053201.44705325
20Nucleotide excision repair_Homo sapiens_hsa034201.40955063
21Osteoclast differentiation_Homo sapiens_hsa043801.40810509
22Viral carcinogenesis_Homo sapiens_hsa052031.40492361
23Base excision repair_Homo sapiens_hsa034101.39610201
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37720163
25T cell receptor signaling pathway_Homo sapiens_hsa046601.37632349
26Shigellosis_Homo sapiens_hsa051311.36281362
27Toxoplasmosis_Homo sapiens_hsa051451.36174883
28RNA transport_Homo sapiens_hsa030131.35685751
29p53 signaling pathway_Homo sapiens_hsa041151.32932360
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.32536223
31MicroRNAs in cancer_Homo sapiens_hsa052061.31346572
32Protein export_Homo sapiens_hsa030601.31083221
33Thyroid cancer_Homo sapiens_hsa052161.30900072
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30746623
35Pancreatic cancer_Homo sapiens_hsa052121.30430304
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30208917
37Hepatitis B_Homo sapiens_hsa051611.30066068
38Herpes simplex infection_Homo sapiens_hsa051681.29928987
39HTLV-I infection_Homo sapiens_hsa051661.25791921
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25548511
41Legionellosis_Homo sapiens_hsa051341.25209019
42Colorectal cancer_Homo sapiens_hsa052101.24436733
43Basal transcription factors_Homo sapiens_hsa030221.23281564
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21204690
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21060276
46Hematopoietic cell lineage_Homo sapiens_hsa046401.20755296
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20483691
48Acute myeloid leukemia_Homo sapiens_hsa052211.19882914
49Apoptosis_Homo sapiens_hsa042101.17606845
50Epstein-Barr virus infection_Homo sapiens_hsa051691.17056894
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.13235699
52Platelet activation_Homo sapiens_hsa046111.12410214
53Proteoglycans in cancer_Homo sapiens_hsa052051.12144174
54Adherens junction_Homo sapiens_hsa045201.11883089
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.10361779
56Proteasome_Homo sapiens_hsa030501.09177311
57Systemic lupus erythematosus_Homo sapiens_hsa053221.08861621
58Focal adhesion_Homo sapiens_hsa045101.08379103
59Other glycan degradation_Homo sapiens_hsa005111.07267502
60Non-homologous end-joining_Homo sapiens_hsa034501.05823084
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04480272
62Homologous recombination_Homo sapiens_hsa034401.04376817
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03335282
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.02508836
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00325151
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97802381
67TNF signaling pathway_Homo sapiens_hsa046680.96487172
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.95866783
69Non-small cell lung cancer_Homo sapiens_hsa052230.95689692
70TGF-beta signaling pathway_Homo sapiens_hsa043500.95427555
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93588158
72N-Glycan biosynthesis_Homo sapiens_hsa005100.93124065
73One carbon pool by folate_Homo sapiens_hsa006700.92415526
74mRNA surveillance pathway_Homo sapiens_hsa030150.91890938
75Salmonella infection_Homo sapiens_hsa051320.89679372
76Prostate cancer_Homo sapiens_hsa052150.89466198
77Malaria_Homo sapiens_hsa051440.88032138
78Pertussis_Homo sapiens_hsa051330.87743691
79Selenocompound metabolism_Homo sapiens_hsa004500.87305728
80ECM-receptor interaction_Homo sapiens_hsa045120.86889209
81Rheumatoid arthritis_Homo sapiens_hsa053230.86752794
82Influenza A_Homo sapiens_hsa051640.86454410
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85698755
84Tuberculosis_Homo sapiens_hsa051520.84556997
85Dorso-ventral axis formation_Homo sapiens_hsa043200.83076075
86mTOR signaling pathway_Homo sapiens_hsa041500.82385035
87VEGF signaling pathway_Homo sapiens_hsa043700.78033962
88Endometrial cancer_Homo sapiens_hsa052130.77498733
89Pathways in cancer_Homo sapiens_hsa052000.76175523
90RNA degradation_Homo sapiens_hsa030180.75191131
91Allograft rejection_Homo sapiens_hsa053300.74518770
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74323870
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73342405
94Regulation of autophagy_Homo sapiens_hsa041400.72484024
95Chemokine signaling pathway_Homo sapiens_hsa040620.70853103
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.69227360
97HIF-1 signaling pathway_Homo sapiens_hsa040660.69201575
98Prolactin signaling pathway_Homo sapiens_hsa049170.69005925
99Pyrimidine metabolism_Homo sapiens_hsa002400.68158826
100Asthma_Homo sapiens_hsa053100.68030152
101FoxO signaling pathway_Homo sapiens_hsa040680.65935796
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65131163
103Bladder cancer_Homo sapiens_hsa052190.65047090
104Inositol phosphate metabolism_Homo sapiens_hsa005620.64480933
105Renal cell carcinoma_Homo sapiens_hsa052110.63537542
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63465941
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63352057
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62233080
109Graft-versus-host disease_Homo sapiens_hsa053320.61899703
110Amoebiasis_Homo sapiens_hsa051460.61718587
111Fanconi anemia pathway_Homo sapiens_hsa034600.60895972
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60668892
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60197981
114Glioma_Homo sapiens_hsa052140.60126078
115Hippo signaling pathway_Homo sapiens_hsa043900.59553988
116Notch signaling pathway_Homo sapiens_hsa043300.59536397
117Hepatitis C_Homo sapiens_hsa051600.59444012
118Lysine degradation_Homo sapiens_hsa003100.52849407
119Glutathione metabolism_Homo sapiens_hsa004800.51185701
120Oocyte meiosis_Homo sapiens_hsa041140.47050148
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.43729731

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