CBLC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.89642004
2bile acid and bile salt transport (GO:0015721)6.34670759
3regulation of water loss via skin (GO:0033561)6.01491208
4establishment of skin barrier (GO:0061436)5.95708968
5sulfur amino acid catabolic process (GO:0000098)5.89469796
6L-phenylalanine catabolic process (GO:0006559)5.87562064
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.87562064
8L-phenylalanine metabolic process (GO:0006558)5.74139820
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.74139820
10aromatic amino acid family catabolic process (GO:0009074)5.31216142
11multicellular organismal water homeostasis (GO:0050891)5.15686446
12cysteine metabolic process (GO:0006534)5.01152188
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.00819830
14indole-containing compound catabolic process (GO:0042436)4.87118729
15indolalkylamine catabolic process (GO:0046218)4.87118729
16tryptophan catabolic process (GO:0006569)4.87118729
17keratinocyte proliferation (GO:0043616)4.82581988
18kynurenine metabolic process (GO:0070189)4.79163249
19negative regulation of keratinocyte proliferation (GO:0010839)4.60581737
20glyoxylate metabolic process (GO:0046487)4.57156067
21tryptophan metabolic process (GO:0006568)4.52469674
22urea cycle (GO:0000050)4.43267662
23urea metabolic process (GO:0019627)4.43267662
24cellular glucuronidation (GO:0052695)4.38924382
25high-density lipoprotein particle remodeling (GO:0034375)4.37141624
26homocysteine metabolic process (GO:0050667)4.34666143
27regulation of triglyceride catabolic process (GO:0010896)4.33072434
28NADH metabolic process (GO:0006734)4.30262055
29bile acid biosynthetic process (GO:0006699)4.28718336
30positive regulation of Cdc42 GTPase activity (GO:0043089)4.25309040
31amino-acid betaine metabolic process (GO:0006577)4.20534752
32water homeostasis (GO:0030104)4.18635654
33positive regulation of pseudopodium assembly (GO:0031274)4.18471238
34keratinization (GO:0031424)4.18300667
35complement activation, alternative pathway (GO:0006957)4.16682833
36GDP-mannose metabolic process (GO:0019673)4.15415618
37serine family amino acid catabolic process (GO:0009071)4.14298799
38ethanol oxidation (GO:0006069)4.13740137
39negative regulation of cholesterol transport (GO:0032375)4.10174653
40negative regulation of sterol transport (GO:0032372)4.10174653
41bile acid metabolic process (GO:0008206)4.08586634
42nitrogen cycle metabolic process (GO:0071941)4.04678201
43phospholipid efflux (GO:0033700)4.04090669
44drug transmembrane transport (GO:0006855)4.03952764
45positive regulation of epidermal cell differentiation (GO:0045606)4.03794374
46angiotensin maturation (GO:0002003)4.02483663
47reverse cholesterol transport (GO:0043691)4.00207290
48drug catabolic process (GO:0042737)4.00134799
49gap junction assembly (GO:0016264)3.99801886
50flavonoid metabolic process (GO:0009812)3.96486250
51glucuronate metabolic process (GO:0019585)3.95839191
52uronic acid metabolic process (GO:0006063)3.95839191
53regulation of protein activation cascade (GO:2000257)3.95763574
54regulation of cholesterol homeostasis (GO:2000188)3.94369740
55regulation of cholesterol esterification (GO:0010872)3.94257867
56epoxygenase P450 pathway (GO:0019373)3.93513168
57epithelial cell-cell adhesion (GO:0090136)3.93032261
58acylglycerol homeostasis (GO:0055090)3.91326401
59triglyceride homeostasis (GO:0070328)3.91326401
60alpha-linolenic acid metabolic process (GO:0036109)3.90245274
61aromatic amino acid family metabolic process (GO:0009072)3.90186927
62plasma lipoprotein particle remodeling (GO:0034369)3.88896061
63protein-lipid complex remodeling (GO:0034368)3.88896061
64macromolecular complex remodeling (GO:0034367)3.88896061
65protein carboxylation (GO:0018214)3.88640626
66peptidyl-glutamic acid carboxylation (GO:0017187)3.88640626
67intestinal cholesterol absorption (GO:0030299)3.86942805
68negative regulation of fibrinolysis (GO:0051918)3.86342202
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.84754684
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81718808
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.80374609
72lysine catabolic process (GO:0006554)3.78948632
73lysine metabolic process (GO:0006553)3.78948632
74phospholipid homeostasis (GO:0055091)3.78357862
75regulation of complement activation (GO:0030449)3.74445961
76cellular ketone body metabolic process (GO:0046950)3.72866673
77regulation of fibrinolysis (GO:0051917)3.69726487
78ethanol metabolic process (GO:0006067)3.66816135
79regulation of pseudopodium assembly (GO:0031272)3.66489842
80intestinal absorption (GO:0050892)3.65252589
81primary alcohol catabolic process (GO:0034310)3.64740366
82regulation of bile acid biosynthetic process (GO:0070857)3.63198388
83COPI coating of Golgi vesicle (GO:0048205)3.62427275
84Golgi transport vesicle coating (GO:0048200)3.62427275
85cellular modified amino acid catabolic process (GO:0042219)3.62013441
86alkaloid metabolic process (GO:0009820)3.61271462
87positive regulation of lipoprotein lipase activity (GO:0051006)3.61093356
88positive regulation of triglyceride lipase activity (GO:0061365)3.61093356
89cholesterol homeostasis (GO:0042632)3.58817309
90intestinal epithelial cell development (GO:0060576)3.58053455
91activation of Rac GTPase activity (GO:0032863)3.55941923
92alpha-amino acid catabolic process (GO:1901606)3.55821556
93sterol homeostasis (GO:0055092)3.54807044
94regulation of keratinocyte proliferation (GO:0010837)3.53641780
95acute-phase response (GO:0006953)3.52998054
96pyrimidine nucleoside catabolic process (GO:0046135)3.51162676
97exogenous drug catabolic process (GO:0042738)3.49671752
98cell-substrate junction assembly (GO:0007044)3.48144401
99benzene-containing compound metabolic process (GO:0042537)3.47487930
100short-chain fatty acid metabolic process (GO:0046459)3.46786995
101cellular amino acid catabolic process (GO:0009063)3.46226033
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.45941212
103purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45501315
1043-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45501315
105regulation of cholesterol metabolic process (GO:0090181)3.45067411
106regulation of guanylate cyclase activity (GO:0031282)3.44390362
107tyrosine metabolic process (GO:0006570)3.43988245
108fat-soluble vitamin biosynthetic process (GO:0042362)3.39835006
109carnitine metabolic process (GO:0009437)3.39606225
110drug transport (GO:0015893)3.38878387
111indolalkylamine metabolic process (GO:0006586)3.38345481
112citrulline biosynthetic process (GO:0019240)3.38096485
113serine family amino acid metabolic process (GO:0009069)3.37481948
114renal system process involved in regulation of blood volume (GO:0001977)3.37391914
115glutamate metabolic process (GO:0006536)3.33046536
116proline biosynthetic process (GO:0006561)3.31443292
117plasma lipoprotein particle assembly (GO:0034377)3.30085053
118positive regulation of epidermis development (GO:0045684)3.29637546
119cholesterol efflux (GO:0033344)3.27856735
120response to nitrosative stress (GO:0051409)3.27279840
121bundle of His cell to Purkinje myocyte communication (GO:0086069)3.25656145
122fatty acid oxidation (GO:0019395)3.24370465
123urate metabolic process (GO:0046415)3.24206978
124cellular biogenic amine catabolic process (GO:0042402)3.23791429
125amine catabolic process (GO:0009310)3.23791429
126drug metabolic process (GO:0017144)3.22634391
127arginine metabolic process (GO:0006525)3.22526682
128plasma lipoprotein particle clearance (GO:0034381)3.20958385
129ketone body metabolic process (GO:1902224)3.20268302
130branching involved in mammary gland duct morphogenesis (GO:0060444)3.19578917
131proline metabolic process (GO:0006560)3.19170337
132lipoprotein metabolic process (GO:0042157)3.18802738
133tight junction assembly (GO:0070830)3.18641739
134serine family amino acid biosynthetic process (GO:0009070)3.16813254
135lipid oxidation (GO:0034440)3.16746414
136keratinocyte differentiation (GO:0030216)3.13264079
137regulation of keratinocyte differentiation (GO:0045616)3.08455947
138protein autoprocessing (GO:0016540)3.06355910
139glutamine family amino acid biosynthetic process (GO:0009084)3.05367537
140positive regulation of keratinocyte differentiation (GO:0045618)3.00957268
141citrulline metabolic process (GO:0000052)2.97874348
142intermediate filament organization (GO:0045109)2.94106620
143epidermal cell differentiation (GO:0009913)2.91535288
144nucleotide-sugar biosynthetic process (GO:0009226)2.88838700
145regulation of viral release from host cell (GO:1902186)2.87910879
146regulation of cholesterol biosynthetic process (GO:0045540)2.86005370
147negative regulation of cell fate specification (GO:0009996)2.82768387
148regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.81367453
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.81245651
150regulation of vitamin metabolic process (GO:0030656)2.80780663
151epidermis development (GO:0008544)2.78254746
152keratinocyte development (GO:0003334)2.78073267
153renal filtration (GO:0097205)2.76335304
154cell-cell junction assembly (GO:0007043)2.74344977
155fructose metabolic process (GO:0006000)2.73404458
156regulation of epidermal cell differentiation (GO:0045604)2.73204788
157O-glycan processing (GO:0016266)2.72488626
158regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.71092217
159endocrine process (GO:0050886)2.71092217
160regulation of systemic arterial blood pressure by hormone (GO:0001990)2.71092217
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69524969
162phenylpropanoid metabolic process (GO:0009698)2.69161381
163positive regulation of respiratory burst (GO:0060267)2.66724219
164maintenance of gastrointestinal epithelium (GO:0030277)2.66456310
165renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.66113746
166antimicrobial humoral response (GO:0019730)2.64738878
167regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64141910
168regulation of epidermis development (GO:0045682)2.63754773
169surfactant homeostasis (GO:0043129)2.63633446
170sphingomyelin metabolic process (GO:0006684)2.63455331
171protein retention in ER lumen (GO:0006621)2.63440859
172regulation of systemic arterial blood pressure (GO:0003073)2.62400331
173regulation of metalloenzyme activity (GO:0048552)2.61538619
174retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58904866
175regulation of respiratory burst (GO:0060263)2.58863910
176negative regulation of epidermis development (GO:0045683)2.58403718
177diterpenoid biosynthetic process (GO:0016102)2.57230577
178atrioventricular valve morphogenesis (GO:0003181)2.56662657
179glutathione biosynthetic process (GO:0006750)2.52918362
180vitamin transmembrane transport (GO:0035461)2.52596567
181auditory receptor cell differentiation (GO:0042491)2.52504374
182prostanoid metabolic process (GO:0006692)2.50317722
183prostaglandin metabolic process (GO:0006693)2.50317722
184desmosome organization (GO:0002934)10.1977474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.89406324
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.21665037
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.74485077
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.73236036
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.00907975
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.84211561
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33824883
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.59034105
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44387633
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39987219
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09726526
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.46199985
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43197367
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40067145
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.25214220
16* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04343149
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97301851
18* GATA4_25053715_ChIP-Seq_YYC3_Human1.85905365
19* SOX2_20726797_ChIP-Seq_SW620_Human1.79040998
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.77087631
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73662321
22CLOCK_20551151_ChIP-Seq_293T_Human1.71638761
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.67848642
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.64031134
25GATA6_25053715_ChIP-Seq_YYC3_Human1.62003657
26* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61694995
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58564801
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58510655
29* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57857796
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56085535
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51673439
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49611672
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.49446155
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45854452
35* KLF5_25053715_ChIP-Seq_YYC3_Human1.45572075
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.40927923
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33767269
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33384669
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31313806
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29359259
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.29322717
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27638484
43RACK7_27058665_Chip-Seq_MCF-7_Human1.27459152
44TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26308061
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25731347
46P68_20966046_ChIP-Seq_HELA_Human1.24681416
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.23480965
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21972972
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21871830
50SMC4_20622854_ChIP-Seq_HELA_Human1.21336024
51* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21175724
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21128118
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20136042
54ZNF263_19887448_ChIP-Seq_K562_Human1.19797644
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15280226
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14537922
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.14346096
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13300962
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13119359
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12871881
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11979252
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11126163
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11052070
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08085930
65FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07214921
66SA1_27219007_Chip-Seq_Bcells_Human1.07157770
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06950948
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04590490
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04158035
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04030758
71ATF3_27146783_Chip-Seq_COLON_Human1.03874876
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03419717
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03042318
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.02983414
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02249549
76LXR_22292898_ChIP-Seq_THP-1_Human1.02057909
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01324228
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01113684
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00352577
80VDR_21846776_ChIP-Seq_THP-1_Human0.99969508
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98888174
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.97962743
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97736125
84* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97496486
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97220481
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97177722
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.97096217
88UBF1/2_26484160_Chip-Seq_HMECs_Human0.97017766
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96871406
90* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96834494
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95583425
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95214721
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94494947
94BCL6_27268052_Chip-Seq_Bcells_Human0.91390415
95ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90905466
96* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90742376
97KDM2B_26808549_Chip-Seq_K562_Human0.90230450
98AR_21909140_ChIP-Seq_LNCAP_Human0.90041115
99RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88893885
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88322519
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85606648
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84204194
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83781170
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82134231
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81701913
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.80903403
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80086703
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79949257
109* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79657657
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78474043
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77263933
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.77143859
113* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76860972
114* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76684095
115HTT_18923047_ChIP-ChIP_STHdh_Human0.76122342
116TAF2_19829295_ChIP-Seq_ESCs_Human0.76064381
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75345112
118GATA1_22025678_ChIP-Seq_K562_Human0.75331912
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74677879
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73408774
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73408774
122VDR_22108803_ChIP-Seq_LS180_Human0.73338298
123EGR1_19032775_ChIP-ChIP_M12_Human0.68189740
124CREB1_26743006_Chip-Seq_LNCaP_Human0.67450209
125NANOG_18692474_ChIP-Seq_MEFs_Mouse0.67209485
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66787682
127* TP63_22573176_ChIP-Seq_HFKS_Human0.66587196
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66257702
129BCOR_27268052_Chip-Seq_Bcells_Human0.65042934
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.64470061
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63458867
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63058926
133CTCF_27219007_Chip-Seq_Bcells_Human0.63046818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.41137367
2MP0005360_urolithiasis6.30185530
3MP0010234_abnormal_vibrissa_follicle6.01916703
4MP0005085_abnormal_gallbladder_physiolo5.12276187
5MP0008875_abnormal_xenobiotic_pharmacok4.63719440
6MP0005365_abnormal_bile_salt4.39921140
7MP0003252_abnormal_bile_duct3.56043616
8MP0001666_abnormal_nutrient_absorption3.39703962
9MP0000566_synostosis3.31683439
10MP0003806_abnormal_nucleotide_metabolis3.18902326
11MP0004019_abnormal_vitamin_homeostasis2.97908773
12MP0010329_abnormal_lipoprotein_level2.70092331
13MP0010352_gastrointestinal_tract_polyps2.53379047
14MP0003283_abnormal_digestive_organ2.52098892
15MP0009840_abnormal_foam_cell2.43952468
16MP0003195_calcinosis2.34063689
17MP0009379_abnormal_foot_pigmentation2.28920406
18MP0005409_darkened_coat_color2.26373383
19MP0000678_abnormal_parathyroid_gland2.25741262
20MP0003941_abnormal_skin_development2.22589806
21MP0005332_abnormal_amino_acid2.19755172
22MP0002138_abnormal_hepatobiliary_system2.19332887
23MP0005083_abnormal_biliary_tract2.04425608
24MP0004264_abnormal_extraembryonic_tissu2.03024680
25MP0003191_abnormal_cellular_cholesterol2.02198674
26MP0009643_abnormal_urine_homeostasis1.79204758
27MP0009053_abnormal_anal_canal1.67590109
28MP0002796_impaired_skin_barrier1.67295593
29MP0002118_abnormal_lipid_homeostasis1.66095394
30MP0010771_integument_phenotype1.63932371
31MP0002822_catalepsy1.62752918
32MP0003705_abnormal_hypodermis_morpholog1.58519026
33MP0005451_abnormal_body_composition1.56504401
34MP0005023_abnormal_wound_healing1.56124633
35MP0000609_abnormal_liver_physiology1.54821993
36MP0003868_abnormal_feces_composition1.53280115
37MP0000462_abnormal_digestive_system1.43972756
38MP0005275_abnormal_skin_tensile1.42446990
39MP0005319_abnormal_enzyme/_coenzyme1.40262700
40MP0003300_gastrointestinal_ulcer1.37940396
41MP0002254_reproductive_system_inflammat1.32933923
42MP0010678_abnormal_skin_adnexa1.32526377
43MP0005377_hearing/vestibular/ear_phenot1.32523552
44MP0003878_abnormal_ear_physiology1.32523552
45MP0005636_abnormal_mineral_homeostasis1.31738271
46MP0004381_abnormal_hair_follicle1.30302538
47MP0000490_abnormal_crypts_of1.26576605
48MP0004858_abnormal_nervous_system1.25162779
49MP0002098_abnormal_vibrissa_morphology1.23694676
50MP0001756_abnormal_urination1.21950237
51MP0008260_abnormal_autophagy1.17348015
52MP0005584_abnormal_enzyme/coenzyme_acti1.14379771
53MP0004043_abnormal_pH_regulation1.13317072
54MP0003183_abnormal_peptide_metabolism1.11192930
55MP0003693_abnormal_embryo_hatching1.04872211
56MP0004272_abnormal_basement_membrane1.03272431
57MP0003453_abnormal_keratinocyte_physiol1.03194345
58MP0001764_abnormal_homeostasis1.03139241
59MP0005084_abnormal_gallbladder_morpholo1.01703869
60MP0003566_abnormal_cell_adhesion1.01658816
61MP0001765_abnormal_ion_homeostasis1.00550243
62MP0002234_abnormal_pharynx_morphology1.00251069
63MP0000627_abnormal_mammary_gland0.97242674
64MP0003866_abnormal_defecation0.97229026
65MP0005076_abnormal_cell_differentiation0.95500216
66MP0005501_abnormal_skin_physiology0.93966529
67MP0003186_abnormal_redox_activity0.91072998
68MP0005058_abnormal_lysosome_morphology0.88701386
69MP0000477_abnormal_intestine_morphology0.88222646
70MP0000858_altered_metastatic_potential0.87497243
71MP0004782_abnormal_surfactant_physiolog0.87157055
72MP0001216_abnormal_epidermal_layer0.86165737
73MP0004947_skin_inflammation0.83491658
74MP0002136_abnormal_kidney_physiology0.82873964
75MP0000598_abnormal_liver_morphology0.82677147
76MP0009780_abnormal_chondrocyte_physiolo0.81947969
77MP0000003_abnormal_adipose_tissue0.81003521
78MP0005167_abnormal_blood-brain_barrier0.80692637
79MP0000367_abnormal_coat/_hair0.78804660
80MP0005381_digestive/alimentary_phenotyp0.78550751
81MP0005375_adipose_tissue_phenotype0.78090092
82MP0010155_abnormal_intestine_physiology0.75859343
83MP0000377_abnormal_hair_follicle0.75282440
84MP0002089_abnormal_postnatal_growth/wei0.75151912
85MP0005220_abnormal_exocrine_pancreas0.73692184
86MP0000604_amyloidosis0.72792134
87MP0002876_abnormal_thyroid_physiology0.72626476
88MP0003315_abnormal_perineum_morphology0.71892345
89MP0009642_abnormal_blood_homeostasis0.71501123
90MP0005666_abnormal_adipose_tissue0.70625516
91MP0001663_abnormal_digestive_system0.70406500
92MP0002249_abnormal_larynx_morphology0.70249240
93MP0001664_abnormal_digestion0.68062760
94MP0005670_abnormal_white_adipose0.67171086
95MP0002060_abnormal_skin_morphology0.66904820
96MP0004957_abnormal_blastocyst_morpholog0.66713547
97MP0000537_abnormal_urethra_morphology0.66550006
98MP0004185_abnormal_adipocyte_glucose0.65931380
99MP0000538_abnormal_urinary_bladder0.64325316
100MP0000013_abnormal_adipose_tissue0.63588517
101MP0000762_abnormal_tongue_morphology0.63054122
102MP0009764_decreased_sensitivity_to0.62434494
103MP0001873_stomach_inflammation0.61859508
104MP0000427_abnormal_hair_cycle0.60456112
105MP0005408_hypopigmentation0.60104532
106MP0001881_abnormal_mammary_gland0.58746150
107MP0008469_abnormal_protein_level0.58143484
108MP0000470_abnormal_stomach_morphology0.58110553
109MP0001188_hyperpigmentation0.57656335
110MP0005257_abnormal_intraocular_pressure0.57087276
111MP0001191_abnormal_skin_condition0.56807651
112MP0003011_delayed_dark_adaptation0.56275057
113MP0002111_abnormal_tail_morphology0.55773582
114MP0010030_abnormal_orbit_morphology0.55071620
115MP0005647_abnormal_sex_gland0.54870468
116MP0003718_maternal_effect0.53878932
117MP0000467_abnormal_esophagus_morphology0.53775312
118MP0008872_abnormal_physiological_respon0.52903556
119MP0002078_abnormal_glucose_homeostasis0.51835063
120MP0003045_fibrosis0.51779542
121MP0000613_abnormal_salivary_gland0.51204666
122MP0005395_other_phenotype0.51190858
123MP0009765_abnormal_xenobiotic_induced0.50597858
124MP0002928_abnormal_bile_duct0.50047444
125MP0003638_abnormal_response/metabolism_0.49363960
126MP0005376_homeostasis/metabolism_phenot0.48676317
127MP0009763_increased_sensitivity_to0.48436385
128MP0001849_ear_inflammation0.47492404
129MP0002132_abnormal_respiratory_system0.47469982
130MP0000579_abnormal_nail_morphology0.47319215
131MP0002168_other_aberrant_phenotype0.45164562
132MP0000383_abnormal_hair_follicle0.44573771
133MP0009931_abnormal_skin_appearance0.44440144
134MP0005166_decreased_susceptibility_to0.42532031

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.77179402
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.51019447
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.39663539
4Plantar hyperkeratosis (HP:0007556)5.33362916
5Abnormality of nail color (HP:0100643)5.22329422
6Xanthomatosis (HP:0000991)5.20917659
7Milia (HP:0001056)4.88293378
8Deep venous thrombosis (HP:0002625)4.86729414
9Palmoplantar hyperkeratosis (HP:0000972)4.64177491
10Hypobetalipoproteinemia (HP:0003563)4.61236926
11Abnormal hair laboratory examination (HP:0003328)4.57144252
12Hyperlipoproteinemia (HP:0010980)4.35093408
13Palmar hyperkeratosis (HP:0010765)4.30840987
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.24353385
15Prolonged partial thromboplastin time (HP:0003645)4.07675626
16Thick nail (HP:0001805)4.03853955
17Hyperglycinuria (HP:0003108)3.91759685
18Flat acetabular roof (HP:0003180)3.76058169
19Hypolipoproteinemia (HP:0010981)3.70503629
20Hyperammonemia (HP:0001987)3.57263820
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56521160
22Gout (HP:0001997)3.53095903
23Complement deficiency (HP:0004431)3.52277542
24Malnutrition (HP:0004395)3.50203004
25Hyperglycinemia (HP:0002154)3.50045164
26Hypoglycemic coma (HP:0001325)3.49323784
27Fat malabsorption (HP:0002630)3.45503864
28Nail dystrophy (HP:0008404)3.43266534
29Hypoalphalipoproteinemia (HP:0003233)3.38632484
30Abnormality of serine family amino acid metabolism (HP:0010894)3.38149083
31Abnormality of glycine metabolism (HP:0010895)3.38149083
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.36046128
33Ridged nail (HP:0001807)3.34514873
34Abnormal blistering of the skin (HP:0008066)3.29694098
35Right ventricular cardiomyopathy (HP:0011663)3.27910536
36Abnormality of purine metabolism (HP:0004352)3.19332184
37Atrophic scars (HP:0001075)3.19194116
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17588351
39Ketosis (HP:0001946)3.17456147
40Abnormal cartilage morphology (HP:0002763)3.12438531
41Conjugated hyperbilirubinemia (HP:0002908)3.08552245
42Epidermoid cyst (HP:0200040)3.05461809
43Posterior subcapsular cataract (HP:0007787)2.99395853
44Abnormality of nucleobase metabolism (HP:0010932)2.95909986
45Pterygium (HP:0001059)2.91604053
46Hypotrichosis (HP:0001006)2.91014883
47Abnormality of fatty-acid metabolism (HP:0004359)2.90425134
48Late onset (HP:0003584)2.90363406
49Abdominal distention (HP:0003270)2.88206505
50Hyperactive renin-angiotensin system (HP:0000841)2.86205099
51Sparse eyelashes (HP:0000653)2.83461344
52Lip pit (HP:0100267)2.82445389
53Joint hemorrhage (HP:0005261)2.82435597
54Thin bony cortex (HP:0002753)2.82375148
55Abnormality of the common coagulation pathway (HP:0010990)2.80099579
56Hypercholesterolemia (HP:0003124)2.79941182
57Esophageal varix (HP:0002040)2.75030602
58Focal segmental glomerulosclerosis (HP:0000097)2.75008240
59Hypoplasia of dental enamel (HP:0006297)2.70636865
60Abnormal tarsal ossification (HP:0008369)2.69663827
61Cupped ribs (HP:0000887)2.69093783
62Increased purine levels (HP:0004368)2.63913035
63Hyperuricemia (HP:0002149)2.63913035
64Abnormality of complement system (HP:0005339)2.62215679
65Popliteal pterygium (HP:0009756)2.61473894
66Ketoacidosis (HP:0001993)2.61079893
67Abnormality of the salivary glands (HP:0010286)2.60322331
68Abnormality of methionine metabolism (HP:0010901)2.59353057
69Ileus (HP:0002595)2.57140468
70Neonatal short-limb short stature (HP:0008921)2.54933637
71Abnormality of the intrinsic pathway (HP:0010989)2.52361423
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51032568
73Dicarboxylic aciduria (HP:0003215)2.51032568
74Selective tooth agenesis (HP:0001592)2.49194803
75Abnormality of pyrimidine metabolism (HP:0004353)2.49065591
76Vascular calcification (HP:0004934)2.48778722
77Symphalangism affecting the phalanges of the hand (HP:0009773)2.47826069
78Hydroxyprolinuria (HP:0003080)2.41668631
79Abnormality of proline metabolism (HP:0010907)2.41668631
80Alkalosis (HP:0001948)2.39095302
81Glomerulosclerosis (HP:0000096)2.37532668
82Abnormality of urine glucose concentration (HP:0011016)2.36757242
83Glycosuria (HP:0003076)2.36757242
84Trismus (HP:0000211)2.34191831
85Fragile nails (HP:0001808)2.34077652
86Abnormality of chloride homeostasis (HP:0011422)2.33959238
87Vertebral clefting (HP:0008428)2.33509140
88Villous atrophy (HP:0011473)2.33171711
89Abnormality of small intestinal villus morphology (HP:0011472)2.33171711
90Steatorrhea (HP:0002570)2.33073300
91Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.32124982
92Abnormality of carpal bone ossification (HP:0006257)2.31652893
93Erythema (HP:0010783)2.30942062
94Metabolic acidosis (HP:0001942)2.30303450
95Advanced eruption of teeth (HP:0006288)2.30006818
96Curly hair (HP:0002212)2.29162145
97Hyperbilirubinemia (HP:0002904)2.28655204
98Oral leukoplakia (HP:0002745)2.27371671
99Fragile skin (HP:0001030)2.26976373
100Widely patent fontanelles and sutures (HP:0004492)2.26777539
101Abnormality of renin-angiotensin system (HP:0000847)2.26228242
102Amelogenesis imperfecta (HP:0000705)2.25948487
103Irritability (HP:0000737)2.23569881
104Generalized aminoaciduria (HP:0002909)2.23167722
105Lethargy (HP:0001254)2.22537915
106Proximal tubulopathy (HP:0000114)2.21580447
107Cardiovascular calcification (HP:0011915)2.17739392
108Hepatocellular carcinoma (HP:0001402)2.17705339
109Acanthosis nigricans (HP:0000956)2.15502524
110Distal lower limb amyotrophy (HP:0008944)2.14568388
111Vacuolated lymphocytes (HP:0001922)2.14474210
112Dry hair (HP:0011359)2.14326324
113Mildly elevated creatine phosphokinase (HP:0008180)2.14235317
114Abnormality of the distal phalanx of the thumb (HP:0009617)2.14218483
115Pancreatitis (HP:0001733)2.13241696
116Natal tooth (HP:0000695)2.12233486
117Hemorrhage of the eye (HP:0011885)2.11624876
118Myocardial infarction (HP:0001658)2.11400725
119Pili torti (HP:0003777)2.11397925
120Abnormality of the gastric mucosa (HP:0004295)2.09376142
121Subcapsular cataract (HP:0000523)2.08832188
122Abnormality of permanent molar morphology (HP:0011071)2.08313406
123Abnormality of the dental root (HP:0006486)2.08313406
124Taurodontia (HP:0000679)2.08313406
125Abnormality of the distal phalanges of the toes (HP:0010182)2.07861017
126Hypoglycemic seizures (HP:0002173)2.07693702
127Upper limb amyotrophy (HP:0009129)2.05663639
128Distal upper limb amyotrophy (HP:0007149)2.05663639
129Decreased circulating renin level (HP:0003351)2.04911761
130Axonal loss (HP:0003447)2.01846350
131Hyperphosphaturia (HP:0003109)2.01201139
132Rickets (HP:0002748)2.00948390
133Delayed CNS myelination (HP:0002188)1.99846478
134Hyperglycemia (HP:0003074)1.98135892
135Ankyloglossia (HP:0010296)1.97572539
136Abnormality of serum amino acid levels (HP:0003112)1.97340113
137Flat capital femoral epiphysis (HP:0003370)1.97297628
138Hyperparathyroidism (HP:0000843)1.96685822
139Corneal erosion (HP:0200020)1.96513420
140Bronchomalacia (HP:0002780)1.96460855
141Ventricular tachycardia (HP:0004756)1.94984395
142Dehydration (HP:0001944)1.93444032
143Palmoplantar keratoderma (HP:0000982)1.93302923
144Woolly hair (HP:0002224)1.93225096
145Systemic lupus erythematosus (HP:0002725)1.92294706
146Visceral angiomatosis (HP:0100761)1.91161956
147Oligodontia (HP:0000677)1.90674609
148Abnormality of molar (HP:0011077)1.90282458
149Abnormality of molar morphology (HP:0011070)1.90282458
150Amniotic constriction ring (HP:0009775)1.89722960
151Abnormality of placental membranes (HP:0011409)1.89722960
152Congenital ichthyosiform erythroderma (HP:0007431)1.89406136
153Onycholysis (HP:0001806)1.89313960
154Nephrolithiasis (HP:0000787)1.89222340
155Sparse scalp hair (HP:0002209)1.86955933
156Broad face (HP:0000283)1.86900278
157Delayed epiphyseal ossification (HP:0002663)1.84735487
158Abnormality of the dental pulp (HP:0006479)1.84123701
159Anonychia (HP:0001798)1.83942022
160Symptomatic seizures (HP:0011145)1.83920901
161Abnormality of the 1st metacarpal (HP:0010009)1.83892650
162Alopecia of scalp (HP:0002293)1.82932222
163Absent eyelashes (HP:0000561)1.82866055
164Neonatal onset (HP:0003623)1.81107950
165Spontaneous abortion (HP:0005268)1.80899727
166Spastic diplegia (HP:0001264)1.80399152
167Neonatal death (HP:0003811)1.79047042
168Hyponatremia (HP:0002902)1.78247550
169Cervical subluxation (HP:0003308)1.75518822
170Septate vagina (HP:0001153)1.75137207
171Pustule (HP:0200039)1.74423589
172Hyperphosphatemia (HP:0002905)1.71996124
173Blepharitis (HP:0000498)1.71105522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK39.11694156
2MST1R5.53101951
3PIK3CA4.28291564
4EPHB23.61819275
5EPHA23.08246330
6FRK3.02974621
7MAP2K22.76034678
8MAP3K22.42014619
9RIPK12.34596654
10BCKDK2.31046764
11MET2.16289181
12SMG12.10780313
13KSR22.01243697
14ERN11.99350801
15NME21.90070232
16SIK11.80563429
17IRAK31.79019588
18MST41.77097103
19FGFR41.74173335
20PTK61.57600075
21MAPK151.49399402
22LMTK21.43123631
23PTK21.35568913
24TAOK11.34584112
25STK241.32414915
26MAP2K11.31679392
27STK38L1.20673529
28PIK3CG1.19498611
29NME11.17594385
30WNK31.13686563
31GRK61.11650431
32INSRR1.11349601
33ARAF1.06441257
34FER1.04162880
35ERBB41.04049793
36MAP3K31.03201982
37TESK20.97290930
38PDGFRA0.94838458
39PRKG20.93018880
40MAP3K10.92917930
41ACVR1B0.92288458
42EEF2K0.89939794
43MAP3K140.88084304
44PBK0.86363707
45WNK40.86010687
46LATS10.82948873
47EPHB10.80689607
48NUAK10.80349604
49PKN20.80153241
50ERBB20.76377820
51NTRK10.72510334
52PIM20.72093440
53RPS6KB20.71757266
54LATS20.68422693
55MAP3K60.66716932
56MAPK110.66381570
57EPHA30.65916895
58CDK120.63699465
59DDR20.62279643
60MYLK0.59675641
61MAP3K110.59359435
62MAP3K70.59356406
63MAP3K80.58839909
64PRKD20.58618507
65PRKCI0.58265158
66TRIB30.57798498
67CDC42BPA0.55881520
68TESK10.54701969
69MUSK0.51660599
70CAMK2D0.50369623
71MAP2K60.42743790
72PAK40.39749788
73CSK0.39417272
74OXSR10.38574455
75FLT30.35915784
76DAPK10.35715146
77ILK0.35563079
78CAMK2G0.35351105
79NLK0.34759258
80MAP2K30.33792087
81CDK60.33380354
82STK100.33136271
83RPS6KA40.32523598
84ICK0.31274677
85DYRK1B0.30606244
86BRAF0.30488373
87PRKAA20.30173138
88JAK20.29926468
89RPS6KA20.28225535
90MAP3K90.27179544
91MARK20.26740285
92GSK3A0.26605536
93KDR0.26283032
94MAPKAPK20.25888638
95RET0.25657175
96ABL20.25469719
97ITK0.25096212
98PRPF4B0.23793562
99CDK70.23686072
100DMPK0.22986043
101MAP3K100.22480815
102PDPK10.22187660
103TBK10.21107245
104SIK30.20789569
105IRAK20.20773626
106MAP3K130.20398326
107PDK20.19557351
108CDK90.18870319
109GRK10.18624943
110MAPKAPK30.17857341
111MATK0.17756760
112STK30.16985855
113LRRK20.16848742
114SCYL20.16393463
115PRKCA0.16257213
116PRKCQ0.16048751
117STK380.15708021
118TYK20.15652643
119SGK4940.15334771
120SGK2230.15334771
121IRAK10.14899961
122TLK10.14714559
123AKT30.14538112
124PRKAA10.14331244
125SGK30.13617467
126PRKACG0.13405126
127MELK0.13130528
128PRKCZ0.12567135
129STK390.11853292
130MTOR0.10838589
131AURKB0.09425721
132* SRC0.08391391
133CHUK0.08387847
134FGFR10.08232040
135BMX0.08049533
136IGF1R0.07664690
137MAP3K120.07596952

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.41716686
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26651226
3Sulfur metabolism_Homo sapiens_hsa009203.22791583
4Nitrogen metabolism_Homo sapiens_hsa009102.67231769
5Arginine biosynthesis_Homo sapiens_hsa002202.55529183
6Fatty acid degradation_Homo sapiens_hsa000712.45131976
7Tryptophan metabolism_Homo sapiens_hsa003802.45056285
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42933489
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.41213032
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35281933
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21127340
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19445331
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18994215
14Bile secretion_Homo sapiens_hsa049762.13326776
15Chemical carcinogenesis_Homo sapiens_hsa052042.12566039
16Histidine metabolism_Homo sapiens_hsa003402.11588833
17Fat digestion and absorption_Homo sapiens_hsa049752.08903725
18Butanoate metabolism_Homo sapiens_hsa006502.07143148
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00255468
20Complement and coagulation cascades_Homo sapiens_hsa046101.98178601
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.94448016
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93217074
23Caffeine metabolism_Homo sapiens_hsa002321.91873626
24PPAR signaling pathway_Homo sapiens_hsa033201.82221894
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79989849
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.77026165
27Peroxisome_Homo sapiens_hsa041461.73258819
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.69289683
29Propanoate metabolism_Homo sapiens_hsa006401.65163482
30beta-Alanine metabolism_Homo sapiens_hsa004101.61347072
31Retinol metabolism_Homo sapiens_hsa008301.58145631
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53419429
33Phenylalanine metabolism_Homo sapiens_hsa003601.52967692
34Folate biosynthesis_Homo sapiens_hsa007901.50904222
35Fatty acid metabolism_Homo sapiens_hsa012121.49679412
36Tyrosine metabolism_Homo sapiens_hsa003501.46022108
37Sulfur relay system_Homo sapiens_hsa041221.43515776
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39985412
39Selenocompound metabolism_Homo sapiens_hsa004501.37390226
40Pyruvate metabolism_Homo sapiens_hsa006201.37182484
41Starch and sucrose metabolism_Homo sapiens_hsa005001.35526821
42Mineral absorption_Homo sapiens_hsa049781.34437299
43Vitamin digestion and absorption_Homo sapiens_hsa049771.25693753
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20691701
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16927416
46Glutathione metabolism_Homo sapiens_hsa004801.14348336
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11574056
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.09392769
49Carbon metabolism_Homo sapiens_hsa012001.08494855
50ABC transporters_Homo sapiens_hsa020101.06845946
51Staphylococcus aureus infection_Homo sapiens_hsa051501.06677441
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05339035
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.02488560
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99568996
55Glycerolipid metabolism_Homo sapiens_hsa005610.99160919
56Arginine and proline metabolism_Homo sapiens_hsa003300.97959666
57Steroid biosynthesis_Homo sapiens_hsa001000.96874640
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95874725
59Biosynthesis of amino acids_Homo sapiens_hsa012300.94413271
60Fatty acid elongation_Homo sapiens_hsa000620.92225113
61Sphingolipid metabolism_Homo sapiens_hsa006000.90885322
62Galactose metabolism_Homo sapiens_hsa000520.85352315
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78855804
64Pentose phosphate pathway_Homo sapiens_hsa000300.76956723
65Notch signaling pathway_Homo sapiens_hsa043300.76634746
66Linoleic acid metabolism_Homo sapiens_hsa005910.74324227
67* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69271232
68Fructose and mannose metabolism_Homo sapiens_hsa000510.67818218
69Ether lipid metabolism_Homo sapiens_hsa005650.67364515
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63523946
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62032568
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59518025
73Renin-angiotensin system_Homo sapiens_hsa046140.56123637
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52642402
75ECM-receptor interaction_Homo sapiens_hsa045120.52001219
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51345947
77Metabolic pathways_Homo sapiens_hsa011000.51180398
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50737054
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47970940
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44870156
81N-Glycan biosynthesis_Homo sapiens_hsa005100.44266234
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.43892898
83Lysine degradation_Homo sapiens_hsa003100.39610988
84Vibrio cholerae infection_Homo sapiens_hsa051100.36523938
85Glucagon signaling pathway_Homo sapiens_hsa049220.33156199
86Amoebiasis_Homo sapiens_hsa051460.29736971
87Tight junction_Homo sapiens_hsa045300.27937000
88Protein digestion and absorption_Homo sapiens_hsa049740.27753793
89Arachidonic acid metabolism_Homo sapiens_hsa005900.27627446
90Bladder cancer_Homo sapiens_hsa052190.25655085
91One carbon pool by folate_Homo sapiens_hsa006700.24912215
92Small cell lung cancer_Homo sapiens_hsa052220.24561676
93Prion diseases_Homo sapiens_hsa050200.24076147
94AMPK signaling pathway_Homo sapiens_hsa041520.23944177
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.23795029
96* Insulin signaling pathway_Homo sapiens_hsa049100.23069709
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22006685
98Hepatitis C_Homo sapiens_hsa051600.21905248
99Fatty acid biosynthesis_Homo sapiens_hsa000610.21729040
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21168551
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20889133
102Salmonella infection_Homo sapiens_hsa051320.20089113
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19998752
104Focal adhesion_Homo sapiens_hsa045100.18963056
105Thyroid hormone synthesis_Homo sapiens_hsa049180.17166764
106Other glycan degradation_Homo sapiens_hsa005110.16671244
107GnRH signaling pathway_Homo sapiens_hsa049120.15191502
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13282728
109Insulin resistance_Homo sapiens_hsa049310.12571635
110Thyroid cancer_Homo sapiens_hsa052160.09741482
111Vitamin B6 metabolism_Homo sapiens_hsa007500.09678862
112Pancreatic secretion_Homo sapiens_hsa049720.04449815
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.04161983
114Oxidative phosphorylation_Homo sapiens_hsa001900.02923085
115Adherens junction_Homo sapiens_hsa045200.02127390
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.00313206
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0234141
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0177852
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0052423

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