CBLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.84648315
2neuron cell-cell adhesion (GO:0007158)5.80596913
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61247745
4synaptic vesicle exocytosis (GO:0016079)5.24982806
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15673470
6response to pheromone (GO:0019236)5.07586405
7regulation of glutamate receptor signaling pathway (GO:1900449)4.97555981
8glutamate secretion (GO:0014047)4.84854675
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.74652439
10protein localization to synapse (GO:0035418)4.69905289
11regulation of synaptic vesicle exocytosis (GO:2000300)4.68570579
12neuron recognition (GO:0008038)4.66039880
13cellular potassium ion homeostasis (GO:0030007)4.60367751
14locomotory exploration behavior (GO:0035641)4.53784796
15startle response (GO:0001964)4.52481152
16neurotransmitter secretion (GO:0007269)4.51709154
17axonal fasciculation (GO:0007413)4.45031450
18neuronal action potential propagation (GO:0019227)4.41702030
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41181035
20auditory behavior (GO:0031223)4.39396639
21synaptic vesicle maturation (GO:0016188)4.38746136
22sodium ion export (GO:0071436)4.33882843
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30160673
24presynaptic membrane organization (GO:0097090)4.28074756
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.19628538
26regulation of synaptic vesicle transport (GO:1902803)4.12991338
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.12210777
28pyrimidine nucleobase catabolic process (GO:0006208)4.07589938
29presynaptic membrane assembly (GO:0097105)4.05324163
30postsynaptic membrane organization (GO:0001941)3.92138275
31neurotransmitter-gated ion channel clustering (GO:0072578)3.88905474
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87638805
33exploration behavior (GO:0035640)3.86199082
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.81877793
35cerebellar Purkinje cell differentiation (GO:0021702)3.79524119
36layer formation in cerebral cortex (GO:0021819)3.78541959
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76901407
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70930855
39regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.69493004
40cell migration in hindbrain (GO:0021535)3.69347138
41neuron-neuron synaptic transmission (GO:0007270)3.69096687
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.66119064
43synaptic transmission, glutamatergic (GO:0035249)3.62896742
44* positive regulation of synapse assembly (GO:0051965)3.62659118
45serotonin metabolic process (GO:0042428)3.62069843
46regulation of neuronal synaptic plasticity (GO:0048168)3.60920436
47glutamate receptor signaling pathway (GO:0007215)3.60352294
48neurotransmitter transport (GO:0006836)3.58361320
49transmission of nerve impulse (GO:0019226)3.57137095
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.55036544
51cell communication by electrical coupling (GO:0010644)3.54057038
52L-amino acid import (GO:0043092)3.52058326
53potassium ion homeostasis (GO:0055075)3.50806483
54response to auditory stimulus (GO:0010996)3.50178761
55gamma-aminobutyric acid transport (GO:0015812)3.48263826
56positive regulation of dendritic spine development (GO:0060999)3.47646405
57negative regulation of dendrite morphogenesis (GO:0050774)3.45886514
58positive regulation of synapse maturation (GO:0090129)3.42729838
59dendritic spine morphogenesis (GO:0060997)3.42311940
60behavioral fear response (GO:0001662)3.40389297
61behavioral defense response (GO:0002209)3.40389297
62urinary tract smooth muscle contraction (GO:0014848)3.37269380
63regulation of dendritic spine morphogenesis (GO:0061001)3.35381322
64mechanosensory behavior (GO:0007638)3.33111432
65regulation of voltage-gated calcium channel activity (GO:1901385)3.32240031
66neuronal ion channel clustering (GO:0045161)3.31957247
67regulation of neurotransmitter levels (GO:0001505)3.31032712
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28836719
69regulation of synapse structural plasticity (GO:0051823)3.28602549
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.27898807
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27481696
72negative regulation of dendrite development (GO:2000171)3.26723158
73synaptic vesicle endocytosis (GO:0048488)3.25665393
74regulation of neurotransmitter transport (GO:0051588)3.22507311
75nucleobase catabolic process (GO:0046113)3.22128229
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21230517
77synapse assembly (GO:0007416)3.21172930
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20021866
79cell communication involved in cardiac conduction (GO:0086065)3.19303941
80* regulation of synapse assembly (GO:0051963)3.17906536
81regulation of glutamate secretion (GO:0014048)3.17831430
82regulation of postsynaptic membrane potential (GO:0060078)3.17813652
83proline transport (GO:0015824)3.17547936
84membrane hyperpolarization (GO:0060081)3.16607669
85neurotransmitter uptake (GO:0001504)3.16416752
86cell differentiation in hindbrain (GO:0021533)3.16210902
87negative regulation of microtubule polymerization (GO:0031115)3.14220688
88neuromuscular process controlling balance (GO:0050885)3.12289439
89primary amino compound metabolic process (GO:1901160)3.12146275
90fear response (GO:0042596)3.11555985
91dendrite development (GO:0016358)3.10436266
92regulation of neurotransmitter secretion (GO:0046928)3.10280889
93long-term synaptic potentiation (GO:0060291)3.09938644
94regulation of dendritic spine development (GO:0060998)3.09154925
95potassium ion import (GO:0010107)3.08490845
96establishment of mitochondrion localization (GO:0051654)3.07057440
97axon ensheathment in central nervous system (GO:0032291)3.06443593
98central nervous system myelination (GO:0022010)3.06443593
99membrane depolarization during action potential (GO:0086010)3.05721058
100regulation of penile erection (GO:0060405)3.05681413
101positive regulation of neurotransmitter transport (GO:0051590)3.03998675
102social behavior (GO:0035176)3.02476865
103intraspecies interaction between organisms (GO:0051703)3.02476865
104neuromuscular synaptic transmission (GO:0007274)3.02027307
105long-term memory (GO:0007616)3.01655388
106adult walking behavior (GO:0007628)3.01303932
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01097055
108regulation of vesicle fusion (GO:0031338)3.00523632
109dendritic spine organization (GO:0097061)3.00172533
110cellular sodium ion homeostasis (GO:0006883)3.00087547
111positive regulation of neurotransmitter secretion (GO:0001956)2.99921615
112cerebellar granule cell differentiation (GO:0021707)2.99533779
113central nervous system projection neuron axonogenesis (GO:0021952)2.98908482
114membrane depolarization (GO:0051899)2.98855973
115negative regulation of amino acid transport (GO:0051956)2.98830832
116positive regulation of membrane potential (GO:0045838)2.98586474
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98062238
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97857380
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97672266
120regulation of synaptic plasticity (GO:0048167)2.96658238
121mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.95710932
122learning (GO:0007612)2.94178306
123dendrite morphogenesis (GO:0048813)2.93934236
124energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.92780688
125ATP hydrolysis coupled proton transport (GO:0015991)2.92780688
126regulation of synaptic transmission, GABAergic (GO:0032228)2.92590633
127regulation of cAMP-dependent protein kinase activity (GO:2000479)2.91620303
128positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91244658
129sensory perception of pain (GO:0019233)2.91008909
130activation of protein kinase A activity (GO:0034199)2.90540140
131synaptic transmission (GO:0007268)2.89419163
132transferrin transport (GO:0033572)2.89178380
133regulation of synapse maturation (GO:0090128)2.84701421
134synapse organization (GO:0050808)2.82836984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.84539283
2GBX2_23144817_ChIP-Seq_PC3_Human4.00065640
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15981312
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07332242
5TAF15_26573619_Chip-Seq_HEK293_Human2.98632354
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90898485
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.82808507
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67781691
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67781691
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67087115
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63895512
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62601294
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61042442
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55266272
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.54019315
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53217725
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52730101
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.40536172
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36372402
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30523284
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28451848
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.24539019
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21867943
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18227034
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18085452
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.14643238
27IGF1R_20145208_ChIP-Seq_DFB_Human1.99622348
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99218815
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93880167
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.93206775
31AR_21572438_ChIP-Seq_LNCaP_Human1.93189099
32DROSHA_22980978_ChIP-Seq_HELA_Human1.79750143
33RNF2_27304074_Chip-Seq_NSC_Mouse1.79235662
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.74213908
35SMAD4_21799915_ChIP-Seq_A2780_Human1.70028335
36P300_19829295_ChIP-Seq_ESCs_Human1.69690352
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68768253
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68168438
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60548526
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58394813
41* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55149495
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52122420
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47242620
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44902933
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42674738
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41859535
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36668304
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35720097
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35548507
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35066663
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.33853661
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33036395
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.30713733
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29402801
55ZNF274_21170338_ChIP-Seq_K562_Hela1.29150478
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27091024
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26955131
58AR_25329375_ChIP-Seq_VCAP_Human1.26912198
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19260362
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.18566523
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.18380525
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17520145
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16044094
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16013899
65ER_23166858_ChIP-Seq_MCF-7_Human1.14676660
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13529114
67FUS_26573619_Chip-Seq_HEK293_Human1.11856334
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11586459
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11586459
70* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11046471
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.10612083
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10237019
73STAT3_23295773_ChIP-Seq_U87_Human1.09123329
74AHR_22903824_ChIP-Seq_MCF-7_Human1.08938622
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08138238
76JUN_21703547_ChIP-Seq_K562_Human1.06561714
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05091566
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04951979
79AR_19668381_ChIP-Seq_PC3_Human1.04937194
80TCF4_23295773_ChIP-Seq_U87_Human1.04625122
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.04586715
82* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03952994
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.02978553
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00496307
85* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00482551
86KDM2B_26808549_Chip-Seq_K562_Human0.99917599
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99738472
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99098157
89* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98149691
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97984671
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97145544
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96803381
93* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96383190
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94971894
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.92820660
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92270556
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92001684
98VDR_22108803_ChIP-Seq_LS180_Human0.90974140
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90534579
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89849171
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89780893
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.89246830
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87214323
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87149847
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86464927
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86011238
107KDM2B_26808549_Chip-Seq_REH_Human0.85936944
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84426475
109* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84211314
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83859970
111* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82616649
112SOX9_26525672_Chip-Seq_HEART_Mouse0.81609865
113* TP53_20018659_ChIP-ChIP_R1E_Mouse0.81125440
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81053758
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80226970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.76828336
2MP0004859_abnormal_synaptic_plasticity4.72757549
3MP0003635_abnormal_synaptic_transmissio3.59641125
4MP0005423_abnormal_somatic_nervous3.45028411
5MP0006276_abnormal_autonomic_nervous3.29680382
6MP0003122_maternal_imprinting3.28371348
7MP0002063_abnormal_learning/memory/cond3.05813036
8MP0009745_abnormal_behavioral_response3.05415835
9MP0004270_analgesia3.02930537
10MP0001968_abnormal_touch/_nociception2.95844373
11MP0002064_seizures2.93382373
12MP0009046_muscle_twitch2.83565297
13MP0002735_abnormal_chemical_nociception2.63324815
14MP0002734_abnormal_mechanical_nocicepti2.59884183
15MP0002572_abnormal_emotion/affect_behav2.58914589
16MP0002272_abnormal_nervous_system2.32662862
17MP0001440_abnormal_grooming_behavior2.30076312
18MP0000778_abnormal_nervous_system2.26374249
19MP0002736_abnormal_nociception_after2.24088008
20MP0001486_abnormal_startle_reflex2.23076973
21MP0002733_abnormal_thermal_nociception2.22100577
22MP0005645_abnormal_hypothalamus_physiol2.17089283
23MP0002184_abnormal_innervation2.16402733
24MP0001501_abnormal_sleep_pattern2.12645273
25MP0001970_abnormal_pain_threshold2.08714607
26MP0003787_abnormal_imprinting2.07776347
27MP0001984_abnormal_olfaction1.99773779
28MP0002557_abnormal_social/conspecific_i1.93599524
29MP0002067_abnormal_sensory_capabilities1.92718458
30MP0005646_abnormal_pituitary_gland1.89335628
31MP0004142_abnormal_muscle_tone1.75782224
32MP0002822_catalepsy1.74753551
33MP0001529_abnormal_vocalization1.72232797
34MP0003121_genomic_imprinting1.71546673
35MP0004811_abnormal_neuron_physiology1.61515110
36MP0009780_abnormal_chondrocyte_physiolo1.59479615
37MP0000955_abnormal_spinal_cord1.53867945
38MP0004924_abnormal_behavior1.51353283
39MP0005386_behavior/neurological_phenoty1.51353283
40MP0008569_lethality_at_weaning1.44777341
41MP0002882_abnormal_neuron_morphology1.44545224
42MP0003329_amyloid_beta_deposits1.42740938
43MP0002909_abnormal_adrenal_gland1.39108491
44MP0004858_abnormal_nervous_system1.37900058
45MP0002066_abnormal_motor_capabilities/c1.35740900
46MP0000751_myopathy1.32173766
47MP0001502_abnormal_circadian_rhythm1.29509258
48MP0010386_abnormal_urinary_bladder1.25740231
49MP0002876_abnormal_thyroid_physiology1.25719324
50MP0001188_hyperpigmentation1.24748305
51MP0003690_abnormal_glial_cell1.24176630
52MP0003879_abnormal_hair_cell1.23295625
53MP0001986_abnormal_taste_sensitivity1.19083331
54MP0002638_abnormal_pupillary_reflex1.16786307
55MP0008995_early_reproductive_senescence1.13848667
56MP0002837_dystrophic_cardiac_calcinosis1.13576395
57MP0002152_abnormal_brain_morphology1.12294266
58MP0001905_abnormal_dopamine_level1.12294183
59MP0004742_abnormal_vestibular_system1.07316933
60MP0000631_abnormal_neuroendocrine_gland1.07163674
61MP0000920_abnormal_myelination1.02556010
62MP0002102_abnormal_ear_morphology1.01245333
63MP0003123_paternal_imprinting1.00351297
64MP0000604_amyloidosis0.99459271
65MP0002653_abnormal_ependyma_morphology0.99212301
66MP0002752_abnormal_somatic_nervous0.98075681
67MP0004885_abnormal_endolymph0.97852880
68MP0002069_abnormal_eating/drinking_beha0.97149319
69MP0001963_abnormal_hearing_physiology0.94186647
70MP0005551_abnormal_eye_electrophysiolog0.93050537
71MP0004510_myositis0.91865422
72MP0002751_abnormal_autonomic_nervous0.91490675
73MP0000566_synostosis0.90271272
74MP0000538_abnormal_urinary_bladder0.86251322
75MP0004147_increased_porphyrin_level0.86175571
76MP0004134_abnormal_chest_morphology0.85442796
77MP0004085_abnormal_heartbeat0.83697997
78MP0002229_neurodegeneration0.82147767
79MP0000569_abnormal_digit_pigmentation0.81580119
80MP0001664_abnormal_digestion0.80613324
81MP0003633_abnormal_nervous_system0.78338456
82MP0003183_abnormal_peptide_metabolism0.77546697
83MP0003631_nervous_system_phenotype0.76516673
84MP0008874_decreased_physiological_sensi0.75999250
85MP0005499_abnormal_olfactory_system0.75373200
86MP0005394_taste/olfaction_phenotype0.75373200
87MP0001299_abnormal_eye_distance/0.73452199
88MP0003646_muscle_fatigue0.71102945
89MP0004145_abnormal_muscle_electrophysio0.70668587
90MP0000026_abnormal_inner_ear0.69892522
91MP0001943_abnormal_respiration0.69565012
92MP0008260_abnormal_autophagy0.68296181
93MP0003861_abnormal_nervous_system0.67512932
94MP0008872_abnormal_physiological_respon0.67446358
95MP0008877_abnormal_DNA_methylation0.65220243
96MP0005187_abnormal_penis_morphology0.64669444
97MP0000639_abnormal_adrenal_gland0.64609076
98MP0005409_darkened_coat_color0.64042315
99MP0001177_atelectasis0.63735431
100MP0003137_abnormal_impulse_conducting0.63396874
101MP0001485_abnormal_pinna_reflex0.63316055
102MP0004130_abnormal_muscle_cell0.63111300
103MP0000534_abnormal_ureter_morphology0.62726404
104MP0000013_abnormal_adipose_tissue0.62711900
105MP0010769_abnormal_survival0.62086296
106MP0002082_postnatal_lethality0.61374512
107MP0010770_preweaning_lethality0.61374512
108MP0008961_abnormal_basal_metabolism0.61239407
109MP0003634_abnormal_glial_cell0.60326701
110MP0003632_abnormal_nervous_system0.59990817
111MP0003075_altered_response_to0.59295062
112MP0005253_abnormal_eye_physiology0.58280597
113MP0005535_abnormal_body_temperature0.58269678
114MP0000579_abnormal_nail_morphology0.58241625
115MP0010768_mortality/aging0.57896841
116MP0002282_abnormal_trachea_morphology0.56895557
117MP0003283_abnormal_digestive_organ0.49163802
118MP0001346_abnormal_lacrimal_gland0.48706026

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27796957
2Atonic seizures (HP:0010819)5.55281150
3Febrile seizures (HP:0002373)5.26444042
4Focal seizures (HP:0007359)5.26415193
5Myokymia (HP:0002411)5.20267726
6Epileptic encephalopathy (HP:0200134)5.04545360
7Polyphagia (HP:0002591)4.93358484
8Failure to thrive in infancy (HP:0001531)4.80029452
9Hyperventilation (HP:0002883)4.30103920
10Abnormal eating behavior (HP:0100738)4.18318649
11Abnormality of binocular vision (HP:0011514)4.17564892
12Diplopia (HP:0000651)4.17564892
13Absence seizures (HP:0002121)4.17019537
14Neurofibrillary tangles (HP:0002185)3.84273492
15Dialeptic seizures (HP:0011146)3.83168634
16Abnormal hair whorl (HP:0010721)3.77363165
17Papilledema (HP:0001085)3.75080760
18Broad-based gait (HP:0002136)3.63259806
19Progressive cerebellar ataxia (HP:0002073)3.58516399
20Generalized tonic-clonic seizures (HP:0002069)3.44788338
21Visual hallucinations (HP:0002367)3.32376734
22Esotropia (HP:0000565)3.25486731
23Progressive inability to walk (HP:0002505)3.14756665
24Sleep apnea (HP:0010535)3.07708469
25Abnormality of the labia minora (HP:0012880)3.04687062
26Poor suck (HP:0002033)3.01628973
27Cerebral inclusion bodies (HP:0100314)3.01264858
28Pheochromocytoma (HP:0002666)2.98875460
29Ankle clonus (HP:0011448)2.94953995
30Oligomenorrhea (HP:0000876)2.90036648
31Neuroendocrine neoplasm (HP:0100634)2.88349312
32Excessive salivation (HP:0003781)2.85708395
33Drooling (HP:0002307)2.85708395
34Amblyopia (HP:0000646)2.85169784
35Supranuclear gaze palsy (HP:0000605)2.70327567
36Limb dystonia (HP:0002451)2.65128357
37Hypoventilation (HP:0002791)2.63720819
38Gait imbalance (HP:0002141)2.63230989
39Specific learning disability (HP:0001328)2.62057305
40Absent speech (HP:0001344)2.61914130
41Truncal ataxia (HP:0002078)2.58629183
42Protruding tongue (HP:0010808)2.57168212
43Narrow nasal bridge (HP:0000446)2.55004022
44Inability to walk (HP:0002540)2.53450510
45Obstructive sleep apnea (HP:0002870)2.51492565
46Poor eye contact (HP:0000817)2.50980839
47Fetal akinesia sequence (HP:0001989)2.49283320
48Hemiplegia (HP:0002301)2.48564845
49Abnormal social behavior (HP:0012433)2.48533406
50Impaired social interactions (HP:0000735)2.48533406
51Blue irides (HP:0000635)2.47441832
52Agitation (HP:0000713)2.45989958
53Hyperthyroidism (HP:0000836)2.45228639
54Generalized hypotonia (HP:0001290)2.44167178
55Epileptiform EEG discharges (HP:0011182)2.40738721
56Dysdiadochokinesis (HP:0002075)2.38651361
57Urinary urgency (HP:0000012)2.36812145
58Exotropia (HP:0000577)2.36725464
59Action tremor (HP:0002345)2.33834218
60EEG with generalized epileptiform discharges (HP:0011198)2.33318547
61Impaired vibration sensation in the lower limbs (HP:0002166)2.29454859
62Genetic anticipation (HP:0003743)2.25369078
63Gaze-evoked nystagmus (HP:0000640)2.25048228
64Morphological abnormality of the pyramidal tract (HP:0002062)2.25017999
65Hypsarrhythmia (HP:0002521)2.23522269
66Hypoplasia of the brainstem (HP:0002365)2.23298149
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23298149
68Anxiety (HP:0000739)2.22587650
69Annular pancreas (HP:0001734)2.20741958
70Spastic gait (HP:0002064)2.19856978
71Mutism (HP:0002300)2.18838657
72Depression (HP:0000716)2.18790885
73Impaired smooth pursuit (HP:0007772)2.18056231
74Intention tremor (HP:0002080)2.15089203
75Spastic tetraparesis (HP:0001285)2.14910294
76Medial flaring of the eyebrow (HP:0010747)2.14245282
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.11232108
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11232108
79Congenital primary aphakia (HP:0007707)2.11211727
80Termporal pattern (HP:0011008)2.10991030
81Insidious onset (HP:0003587)2.10991030
82Neuronal loss in central nervous system (HP:0002529)2.10604987
83Vitreoretinal degeneration (HP:0000655)2.05886027
84Growth hormone deficiency (HP:0000824)2.05838342
85Hemiparesis (HP:0001269)2.05508395
86Clonus (HP:0002169)2.05204305
87Delusions (HP:0000746)2.03763006
88Tetraplegia (HP:0002445)2.03497079
89Nephrogenic diabetes insipidus (HP:0009806)1.98770859
90Torticollis (HP:0000473)1.96017788
91Dysmetria (HP:0001310)1.95150856
92Abnormality of the vocal cords (HP:0008777)1.91787969
93Abnormality of the corticospinal tract (HP:0002492)1.91471121
94Syncope (HP:0001279)1.91393967
95Abnormality of salivation (HP:0100755)1.90947401
96Akinesia (HP:0002304)1.90112813
97Abnormality of pain sensation (HP:0010832)1.89746743
98Impaired pain sensation (HP:0007328)1.89746743
99Impaired vibratory sensation (HP:0002495)1.89504621
100Lissencephaly (HP:0001339)1.89015674
101Prolonged QT interval (HP:0001657)1.86590875
102Abnormality of ocular smooth pursuit (HP:0000617)1.85989530
103Generalized myoclonic seizures (HP:0002123)1.84600007
104Urinary bladder sphincter dysfunction (HP:0002839)1.83784853
105Aplasia involving bones of the upper limbs (HP:0009823)1.83686030
106Aplasia of the phalanges of the hand (HP:0009802)1.83686030
107Aplasia involving bones of the extremities (HP:0009825)1.83686030
108Incomplete penetrance (HP:0003829)1.82911865
109Focal dystonia (HP:0004373)1.81895862
110Scanning speech (HP:0002168)1.81653218
111Spastic tetraplegia (HP:0002510)1.81337398
112Acute necrotizing encephalopathy (HP:0006965)1.80760873
113Psychosis (HP:0000709)1.80367683
114Open mouth (HP:0000194)1.80348449
115Neoplasm of the peripheral nervous system (HP:0100007)1.80050079
116Stereotypic behavior (HP:0000733)1.80043022
117Insomnia (HP:0100785)1.79534073
118Irregular epiphyses (HP:0010582)1.78984548
119Abnormal EKG (HP:0003115)1.78967101
120Amyotrophic lateral sclerosis (HP:0007354)1.78793346
121Status epilepticus (HP:0002133)1.78758437
122Hip dysplasia (HP:0001385)1.77622208
123Apathy (HP:0000741)1.77238061
124Abnormal mitochondria in muscle tissue (HP:0008316)1.76138272
125Postural instability (HP:0002172)1.74897045
126Sudden death (HP:0001699)1.74628283
127Rigidity (HP:0002063)1.74571043
128Inappropriate behavior (HP:0000719)1.73722385
129Bradykinesia (HP:0002067)1.73215954
130Craniofacial dystonia (HP:0012179)1.72665932
131Abnormality of the lower motor neuron (HP:0002366)1.72026829
132Shoulder girdle muscle weakness (HP:0003547)1.70382150
133Gait ataxia (HP:0002066)1.69754845
134Lower limb muscle weakness (HP:0007340)1.68969691
135Sporadic (HP:0003745)1.67893790
136Intellectual disability, severe (HP:0010864)1.67050398
137Megalencephaly (HP:0001355)1.67005349
138Cerebral hypomyelination (HP:0006808)1.64734728
139Peripheral hypomyelination (HP:0007182)1.62661776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.76387484
2NTRK34.21703514
3MARK13.96863719
4MAP3K123.30092440
5MAP3K93.10504520
6SIK33.07738465
7MAP3K42.87297679
8MAP2K72.84251759
9PRKD32.71815503
10MINK12.64647376
11NTRK22.60641306
12EPHA42.23298056
13MAP2K42.00587984
14MAPK131.94367348
15KSR11.90497138
16DAPK21.88964559
17BCR1.82371310
18WNK31.79191412
19PAK61.66100682
20SIK21.63368486
21CDK191.58821868
22UHMK11.55071512
23PLK21.41837179
24PNCK1.41511582
25CDK51.34143140
26GRK51.26743809
27DAPK11.24509431
28LIMK11.24339670
29TNIK1.21844491
30CCNB11.20601415
31PHKG21.20468007
32PHKG11.20468007
33NME11.15714119
34PRKCG1.15497131
35OBSCN1.12091359
36PRPF4B1.09705259
37AKT31.04297693
38ERBB41.03739464
39PRKCH1.00218538
40MAPK120.99918888
41MAP3K110.99264368
42TYRO30.92743065
43DYRK20.92599318
44CDK180.92436828
45CAMK1D0.90843859
46OXSR10.90421268
47EPHB20.87735748
48CAMK2A0.87625241
49FES0.86076788
50IRAK20.85953666
51LATS20.85444695
52NTRK10.84452968
53SGK2230.83446374
54SGK4940.83446374
55MUSK0.82845115
56CDK140.81822557
57ERBB30.81687192
58DYRK1A0.79893168
59CSNK1G20.79476067
60CDK150.77101715
61KSR20.75008491
62PRKCE0.74331771
63LMTK20.73474293
64BMPR1B0.73115235
65PDGFRA0.70598403
66PAK30.70179918
67CAMK40.67371592
68SGK20.65793449
69CDK11A0.64836357
70FER0.64026175
71CAMK2B0.63571832
72RIPK40.61738847
73CAMKK20.58981790
74TNK20.57930130
75ADRBK20.57838281
76CAMKK10.56503662
77PRKCZ0.56378630
78CSNK1G30.54591678
79ADRBK10.52998051
80ALK0.52930517
81MAPK100.52289736
82CAMK10.51984145
83ARAF0.50874846
84TSSK60.48392849
85MAPK40.47699728
86RPS6KA20.44239837
87MARK20.44116685
88SGK10.41788224
89BMPR20.41763854
90PKN10.41405168
91EPHA30.41156468
92GRK70.40696672
93DDR20.40069367
94PDK40.40011369
95PDK30.40011369
96STK380.39924241
97STK110.39889305
98CAMK1G0.39380552
99ROCK10.39328308
100PRKG10.38826333
101ROCK20.37918313
102RET0.37147268
103FGFR20.36612325
104CAMK2G0.36124575
105CSNK1A1L0.35996700
106PKN20.35321682
107RPS6KA30.33756210
108PRKACA0.33633551
109PRKCB0.32474731
110DAPK30.32376592
111PDK10.32369051
112PINK10.32107241
113FYN0.31819049
114PRKCA0.31026914
115PIK3CA0.30072701
116SGK30.29982241
117CAMK2D0.29801574
118MAP3K10.27290761
119MAPK80.25710423
120PRKACB0.25571596
121CSNK1E0.24438247
122PDGFRB0.22761837
123GSK3B0.22302117
124CSNK1D0.21348826

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28080306
2Synaptic vesicle cycle_Homo sapiens_hsa047214.09154618
3GABAergic synapse_Homo sapiens_hsa047272.79357139
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70198924
5Collecting duct acid secretion_Homo sapiens_hsa049662.65864974
6Olfactory transduction_Homo sapiens_hsa047402.50252169
7Morphine addiction_Homo sapiens_hsa050322.44437742
8Circadian entrainment_Homo sapiens_hsa047132.32849520
9Glutamatergic synapse_Homo sapiens_hsa047242.27432476
10Taste transduction_Homo sapiens_hsa047422.12767179
11Dopaminergic synapse_Homo sapiens_hsa047282.01148053
12Long-term potentiation_Homo sapiens_hsa047202.00579546
13Amphetamine addiction_Homo sapiens_hsa050311.87467128
14Oxidative phosphorylation_Homo sapiens_hsa001901.86780695
15Serotonergic synapse_Homo sapiens_hsa047261.84179524
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79436380
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76833904
18Vibrio cholerae infection_Homo sapiens_hsa051101.76405058
19Insulin secretion_Homo sapiens_hsa049111.75570762
20Cholinergic synapse_Homo sapiens_hsa047251.73666088
21Salivary secretion_Homo sapiens_hsa049701.71440195
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70481989
23Long-term depression_Homo sapiens_hsa047301.69418596
24Axon guidance_Homo sapiens_hsa043601.61058243
25Cardiac muscle contraction_Homo sapiens_hsa042601.53936485
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53160377
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50430536
28Cocaine addiction_Homo sapiens_hsa050301.43136255
29Phototransduction_Homo sapiens_hsa047441.40485092
30Gastric acid secretion_Homo sapiens_hsa049711.34839531
31Gap junction_Homo sapiens_hsa045401.34513953
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32896347
33Parkinsons disease_Homo sapiens_hsa050121.32348893
34Oxytocin signaling pathway_Homo sapiens_hsa049211.31949802
35Calcium signaling pathway_Homo sapiens_hsa040201.30700975
36Renin secretion_Homo sapiens_hsa049241.29219940
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27830696
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27818979
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27588105
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27526598
41Alzheimers disease_Homo sapiens_hsa050101.18088002
42GnRH signaling pathway_Homo sapiens_hsa049121.03183906
43ErbB signaling pathway_Homo sapiens_hsa040121.00147596
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97800272
45Huntingtons disease_Homo sapiens_hsa050160.95129826
46cAMP signaling pathway_Homo sapiens_hsa040240.91685126
47Melanogenesis_Homo sapiens_hsa049160.88103990
48Estrogen signaling pathway_Homo sapiens_hsa049150.88089150
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87564633
50Glioma_Homo sapiens_hsa052140.87538435
51Phagosome_Homo sapiens_hsa041450.81057078
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78537605
53Oocyte meiosis_Homo sapiens_hsa041140.78248350
54Type II diabetes mellitus_Homo sapiens_hsa049300.75277499
55Butanoate metabolism_Homo sapiens_hsa006500.75082712
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73769093
57Type I diabetes mellitus_Homo sapiens_hsa049400.70954410
58Fatty acid biosynthesis_Homo sapiens_hsa000610.70942021
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70448961
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68965010
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67726177
62Dilated cardiomyopathy_Homo sapiens_hsa054140.67426471
63Bile secretion_Homo sapiens_hsa049760.65458884
64Rheumatoid arthritis_Homo sapiens_hsa053230.62472780
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62224009
66MAPK signaling pathway_Homo sapiens_hsa040100.62151630
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.60840587
68Ras signaling pathway_Homo sapiens_hsa040140.57919820
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.57535664
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57207896
71Alcoholism_Homo sapiens_hsa050340.56840298
72VEGF signaling pathway_Homo sapiens_hsa043700.56232010
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56210218
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.51802009
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.50776837
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49919521
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49673063
78Wnt signaling pathway_Homo sapiens_hsa043100.47795023
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45262477
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45163804
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44862399
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43754043
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43292873
84Inositol phosphate metabolism_Homo sapiens_hsa005620.43056767
85Dorso-ventral axis formation_Homo sapiens_hsa043200.41162085
86Pancreatic secretion_Homo sapiens_hsa049720.40827849
87Thyroid hormone synthesis_Homo sapiens_hsa049180.40706798
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40480004
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40251554
90Vitamin B6 metabolism_Homo sapiens_hsa007500.40249751
91Mineral absorption_Homo sapiens_hsa049780.39837958
92Endometrial cancer_Homo sapiens_hsa052130.39515395
93Histidine metabolism_Homo sapiens_hsa003400.39373834
94Hippo signaling pathway_Homo sapiens_hsa043900.39313474
95Choline metabolism in cancer_Homo sapiens_hsa052310.38715018
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38556839
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38083823
98Ovarian steroidogenesis_Homo sapiens_hsa049130.37314762
99Hedgehog signaling pathway_Homo sapiens_hsa043400.36868668
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36157978
101Rap1 signaling pathway_Homo sapiens_hsa040150.35305633
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34711808
103Glucagon signaling pathway_Homo sapiens_hsa049220.33503129
104Insulin signaling pathway_Homo sapiens_hsa049100.33387148
105Renal cell carcinoma_Homo sapiens_hsa052110.32557078
106Circadian rhythm_Homo sapiens_hsa047100.31220674
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30883087
108Melanoma_Homo sapiens_hsa052180.30681699
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30479298
110Endocytosis_Homo sapiens_hsa041440.30473365
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29755468
112Colorectal cancer_Homo sapiens_hsa052100.29060353
113Prion diseases_Homo sapiens_hsa050200.28718179
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.27816471
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27707115
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25411194
117Ether lipid metabolism_Homo sapiens_hsa005650.23307683
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.22680503
119AMPK signaling pathway_Homo sapiens_hsa041520.20132435

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