CBLN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.86817457
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86195557
3synaptic vesicle exocytosis (GO:0016079)5.78583353
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62572476
5vocalization behavior (GO:0071625)5.50155812
6sodium ion export (GO:0071436)5.49664343
7glutamate secretion (GO:0014047)5.37612228
8regulation of synaptic vesicle exocytosis (GO:2000300)5.33250964
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23108177
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.20699188
11protein localization to synapse (GO:0035418)5.11695365
12regulation of glutamate receptor signaling pathway (GO:1900449)5.06760647
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89358052
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.87776847
15synaptic vesicle maturation (GO:0016188)4.87385782
16L-amino acid import (GO:0043092)4.79164765
17regulation of synaptic vesicle transport (GO:1902803)4.66976889
18negative regulation of dendrite morphogenesis (GO:0050774)4.64348709
19locomotory exploration behavior (GO:0035641)4.64235209
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.63185890
21neurotransmitter secretion (GO:0007269)4.60560091
22presynaptic membrane assembly (GO:0097105)4.51882982
23neuronal action potential propagation (GO:0019227)4.45645515
24postsynaptic membrane organization (GO:0001941)4.37572539
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.30403860
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.29294739
27neurotransmitter-gated ion channel clustering (GO:0072578)4.24004089
28glutamate receptor signaling pathway (GO:0007215)4.22065361
29presynaptic membrane organization (GO:0097090)4.21006716
30exploration behavior (GO:0035640)4.17305413
31cellular sodium ion homeostasis (GO:0006883)4.17188575
32synaptic transmission, glutamatergic (GO:0035249)4.15125545
33neuron-neuron synaptic transmission (GO:0007270)4.14927602
34amino acid import (GO:0043090)4.13533534
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.12084555
36potassium ion import (GO:0010107)4.11334784
37neuron recognition (GO:0008038)4.08662418
38potassium ion homeostasis (GO:0055075)4.06309273
39positive regulation of dendritic spine development (GO:0060999)4.00929368
40regulation of voltage-gated calcium channel activity (GO:1901385)3.93837874
41response to histamine (GO:0034776)3.93315164
42layer formation in cerebral cortex (GO:0021819)3.92534600
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91703644
44positive regulation of synapse assembly (GO:0051965)3.89829674
45neurotransmitter transport (GO:0006836)3.88994341
46proline transport (GO:0015824)3.87778268
47gamma-aminobutyric acid transport (GO:0015812)3.81086203
48regulation of neuronal synaptic plasticity (GO:0048168)3.76767786
49dendritic spine morphogenesis (GO:0060997)3.76530106
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71634842
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70888364
52regulation of postsynaptic membrane potential (GO:0060078)3.69832879
53regulation of neurotransmitter levels (GO:0001505)3.68750576
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.63196786
55cell communication by electrical coupling (GO:0010644)3.62943703
56startle response (GO:0001964)3.59441199
57membrane depolarization during action potential (GO:0086010)3.59324044
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55719461
59positive regulation of membrane potential (GO:0045838)3.55284016
60long-term synaptic potentiation (GO:0060291)3.51083566
61neuromuscular process controlling balance (GO:0050885)3.50861988
62synaptic vesicle endocytosis (GO:0048488)3.49968412
63regulation of dendritic spine development (GO:0060998)3.49872583
64axonal fasciculation (GO:0007413)3.49638634
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.48380856
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44341091
67activation of protein kinase A activity (GO:0034199)3.43742942
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.40307995
69regulation of vesicle fusion (GO:0031338)3.38461307
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37812262
71neuromuscular process controlling posture (GO:0050884)3.37696121
72regulation of ARF protein signal transduction (GO:0032012)3.36960372
73positive regulation of neurotransmitter secretion (GO:0001956)3.36823044
74detection of calcium ion (GO:0005513)3.36802151
75long-term memory (GO:0007616)3.36009671
76positive regulation of neurotransmitter transport (GO:0051590)3.33066559
77neuronal ion channel clustering (GO:0045161)3.32294511
78regulation of neurotransmitter secretion (GO:0046928)3.31465589
79auditory behavior (GO:0031223)3.29500718
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28834672
81positive regulation of synapse maturation (GO:0090129)3.28553179
82cerebellar granule cell differentiation (GO:0021707)3.28462765
83negative regulation of dendrite development (GO:2000171)3.28182784
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27422841
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27063184
86synapse assembly (GO:0007416)3.26285958
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25186810
88neurotransmitter uptake (GO:0001504)3.24585929
89regulation of synaptic plasticity (GO:0048167)3.24418253
90regulation of synapse structural plasticity (GO:0051823)3.21813824
91mechanosensory behavior (GO:0007638)3.21386609
92transmission of nerve impulse (GO:0019226)3.21237939
93regulation of synapse maturation (GO:0090128)3.15163622
94behavioral response to cocaine (GO:0048148)3.15062742
95membrane depolarization (GO:0051899)3.14761299
96righting reflex (GO:0060013)3.14555336
97social behavior (GO:0035176)3.14252213
98intraspecies interaction between organisms (GO:0051703)3.14252213
99cerebellar Purkinje cell differentiation (GO:0021702)3.14250849
100regulation of synapse assembly (GO:0051963)3.13074416
101positive regulation of synaptic transmission (GO:0050806)3.12112592
102regulation of neurotransmitter transport (GO:0051588)3.10619906
103regulation of exocytosis (GO:0017157)3.10102550
104mating behavior (GO:0007617)3.09410264
105cellular potassium ion homeostasis (GO:0030007)3.08620281
106serotonin metabolic process (GO:0042428)3.08190300
107membrane hyperpolarization (GO:0060081)3.07844689
108regulation of glutamate secretion (GO:0014048)3.07566608
109dendritic spine organization (GO:0097061)3.07541535
110regulation of dendritic spine morphogenesis (GO:0061001)3.07105103
111establishment of synaptic vesicle localization (GO:0097480)3.06935673
112synaptic vesicle transport (GO:0048489)3.06935673
113neuromuscular synaptic transmission (GO:0007274)3.04252507
114synapse organization (GO:0050808)3.03820354
115neuromuscular process (GO:0050905)3.03465283
116synaptic transmission (GO:0007268)3.01333745
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00552797
118potassium ion transmembrane transport (GO:0071805)3.00036165
119cellular potassium ion transport (GO:0071804)3.00036165
120regulation of respiratory system process (GO:0044065)2.99714768
121regulation of protein kinase A signaling (GO:0010738)2.99183273
122phosphorelay signal transduction system (GO:0000160)2.98327599
123behavioral fear response (GO:0001662)2.98226012
124behavioral defense response (GO:0002209)2.98226012
125chemosensory behavior (GO:0007635)2.97994539
126axon ensheathment in central nervous system (GO:0032291)2.97519959
127central nervous system myelination (GO:0022010)2.97519959
128cell differentiation in hindbrain (GO:0021533)2.97375178
129regulation of calcium ion-dependent exocytosis (GO:0017158)2.97238464
130learning (GO:0007612)2.97180321
131vesicle transport along microtubule (GO:0047496)2.96812101
132acidic amino acid transport (GO:0015800)2.96579777
133prepulse inhibition (GO:0060134)2.96212157
134calcium ion-dependent exocytosis (GO:0017156)2.95893079
135regulation of synaptic transmission (GO:0050804)2.94512385
136ATP hydrolysis coupled proton transport (GO:0015991)2.94500978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.57385321
2GBX2_23144817_ChIP-Seq_PC3_Human4.18890343
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11238353
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05990872
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99397611
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.68490228
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61429161
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59931600
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59931600
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58992971
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57028569
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.54400277
13TAF15_26573619_Chip-Seq_HEK293_Human2.51683773
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49798622
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48618125
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46317019
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37362420
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37322855
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.36445011
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32736691
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21609961
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.16357834
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09433457
24DROSHA_22980978_ChIP-Seq_HELA_Human2.07635905
25AR_21572438_ChIP-Seq_LNCaP_Human2.06089839
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04075133
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.03066294
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.02658761
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.98344840
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89217109
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84412446
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.84004498
33P300_19829295_ChIP-Seq_ESCs_Human1.78378424
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78169458
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69400669
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66138798
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62607112
38ZNF274_21170338_ChIP-Seq_K562_Hela1.62520213
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.61773179
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59980342
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59849215
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58098051
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55731482
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53067321
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48027639
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47691636
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44416793
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.43965732
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43864169
50RNF2_27304074_Chip-Seq_NSC_Mouse1.41451079
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40694847
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40115217
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39639355
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39132125
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36883692
56FUS_26573619_Chip-Seq_HEK293_Human1.36811991
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36075830
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35640421
59* AR_25329375_ChIP-Seq_VCAP_Human1.34768628
60VDR_22108803_ChIP-Seq_LS180_Human1.33401200
61IGF1R_20145208_ChIP-Seq_DFB_Human1.31412721
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.27758517
63* STAT3_23295773_ChIP-Seq_U87_Human1.23900111
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.23562217
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21320294
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19032502
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18766757
68* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15657243
69* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12366587
70TCF4_23295773_ChIP-Seq_U87_Human1.12000277
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11957281
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11619018
73* AR_19668381_ChIP-Seq_PC3_Human1.09203164
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08916519
75* RUNX2_22187159_ChIP-Seq_PCA_Human1.08644368
76* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08245542
77* ER_23166858_ChIP-Seq_MCF-7_Human1.08239487
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.08218800
79JUN_21703547_ChIP-Seq_K562_Human1.05731929
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03115127
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02150010
82* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01838654
83KDM2B_26808549_Chip-Seq_K562_Human1.01653942
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.00800732
85TP53_18474530_ChIP-ChIP_U2OS_Human0.99330135
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98974055
87AHR_22903824_ChIP-Seq_MCF-7_Human0.98463942
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98428040
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98310960
90* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97981874
91* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97901894
92* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97493657
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96472684
94RING1B_27294783_Chip-Seq_NPCs_Mouse0.95861925
95* PRDM14_20953172_ChIP-Seq_ESCs_Human0.95526570
96BCAT_22108803_ChIP-Seq_LS180_Human0.94892856
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93635362
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.93235063
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92951338
100ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92562497
101WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91454813
102* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91419308
103* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91419308
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89693286
105TP53_16413492_ChIP-PET_HCT116_Human0.89226186
106EWS_26573619_Chip-Seq_HEK293_Human0.88638363
107* KDM2B_26808549_Chip-Seq_REH_Human0.88007206
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86981735
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86505971
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.85906641
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.85187066
112CTCF_27219007_Chip-Seq_Bcells_Human0.82580860
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81991021
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.80891311
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79754689
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79055057
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78546877
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.78393052
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.77272682
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77107233
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77104443
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.76499436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.82949694
2MP0004859_abnormal_synaptic_plasticity5.02870528
3MP0003635_abnormal_synaptic_transmissio4.01657562
4MP0009745_abnormal_behavioral_response3.33892615
5MP0009046_muscle_twitch3.31631211
6MP0004270_analgesia3.29175097
7MP0001968_abnormal_touch/_nociception3.28705222
8MP0002064_seizures3.21659352
9MP0002063_abnormal_learning/memory/cond3.17278794
10MP0002572_abnormal_emotion/affect_behav2.92063162
11MP0005423_abnormal_somatic_nervous2.85575418
12MP0006276_abnormal_autonomic_nervous2.81779198
13MP0003122_maternal_imprinting2.66449158
14MP0002272_abnormal_nervous_system2.60455498
15MP0002736_abnormal_nociception_after2.55924603
16MP0001501_abnormal_sleep_pattern2.55395941
17MP0002734_abnormal_mechanical_nocicepti2.54413119
18MP0001486_abnormal_startle_reflex2.43897777
19MP0001440_abnormal_grooming_behavior2.28617770
20MP0002067_abnormal_sensory_capabilities2.16463958
21MP0003787_abnormal_imprinting2.12967027
22MP0005645_abnormal_hypothalamus_physiol2.06174855
23MP0002733_abnormal_thermal_nociception2.01716663
24MP0002184_abnormal_innervation1.91640507
25MP0005386_behavior/neurological_phenoty1.91048295
26MP0004924_abnormal_behavior1.91048295
27MP0001529_abnormal_vocalization1.90835961
28MP0002735_abnormal_chemical_nociception1.89736294
29MP0000778_abnormal_nervous_system1.87504437
30MP0001970_abnormal_pain_threshold1.87429027
31MP0002557_abnormal_social/conspecific_i1.83687587
32MP0001905_abnormal_dopamine_level1.78914194
33MP0002909_abnormal_adrenal_gland1.70792971
34MP0003329_amyloid_beta_deposits1.59901386
35MP0003879_abnormal_hair_cell1.57950829
36MP0009780_abnormal_chondrocyte_physiolo1.54995955
37MP0002837_dystrophic_cardiac_calcinosis1.54195832
38MP0005646_abnormal_pituitary_gland1.52606024
39MP0004811_abnormal_neuron_physiology1.47360710
40MP0000955_abnormal_spinal_cord1.41413034
41MP0002066_abnormal_motor_capabilities/c1.41049377
42MP0001188_hyperpigmentation1.39806311
43MP0004142_abnormal_muscle_tone1.39004589
44MP0001502_abnormal_circadian_rhythm1.38607567
45MP0008569_lethality_at_weaning1.36428991
46MP0002882_abnormal_neuron_morphology1.31975426
47MP0000751_myopathy1.31763966
48MP0001984_abnormal_olfaction1.29437483
49MP0000013_abnormal_adipose_tissue1.21801781
50MP0004147_increased_porphyrin_level1.21729992
51MP0004858_abnormal_nervous_system1.21526919
52MP0003633_abnormal_nervous_system1.18289232
53MP0000920_abnormal_myelination1.16922442
54MP0003121_genomic_imprinting1.14992259
55MP0001485_abnormal_pinna_reflex1.10333014
56MP0002152_abnormal_brain_morphology1.07463139
57MP0000569_abnormal_digit_pigmentation1.06010915
58MP0004742_abnormal_vestibular_system1.05615504
59MP0008872_abnormal_physiological_respon1.02243101
60MP0005535_abnormal_body_temperature0.99968418
61MP0004145_abnormal_muscle_electrophysio0.98238113
62MP0002822_catalepsy0.98055032
63MP0003631_nervous_system_phenotype0.97176764
64MP0003123_paternal_imprinting0.96091957
65MP0004885_abnormal_endolymph0.95523063
66MP0005551_abnormal_eye_electrophysiolog0.93423422
67MP0000631_abnormal_neuroendocrine_gland0.93253605
68MP0010386_abnormal_urinary_bladder0.91109315
69MP0002229_neurodegeneration0.90532006
70MP0002876_abnormal_thyroid_physiology0.89250278
71MP0001963_abnormal_hearing_physiology0.87234990
72MP0003283_abnormal_digestive_organ0.86953287
73MP0002069_abnormal_eating/drinking_beha0.86167135
74MP0008874_decreased_physiological_sensi0.85986491
75MP0002090_abnormal_vision0.84484303
76MP0004085_abnormal_heartbeat0.82389899
77MP0008877_abnormal_DNA_methylation0.81699300
78MP0004215_abnormal_myocardial_fiber0.80054704
79MP0001664_abnormal_digestion0.78022781
80MP0003183_abnormal_peptide_metabolism0.76282428
81MP0001348_abnormal_lacrimal_gland0.75998306
82MP0003075_altered_response_to0.75903478
83MP0001177_atelectasis0.72516134
84MP0002752_abnormal_somatic_nervous0.72440883
85MP0003634_abnormal_glial_cell0.71941680
86MP0005623_abnormal_meninges_morphology0.71488755
87MP0001986_abnormal_taste_sensitivity0.70364573
88MP0005394_taste/olfaction_phenotype0.70059002
89MP0005499_abnormal_olfactory_system0.70059002
90MP0001943_abnormal_respiration0.69616010
91MP0006072_abnormal_retinal_apoptosis0.68029567
92MP0004484_altered_response_of0.66322634
93MP0000639_abnormal_adrenal_gland0.64373284
94MP0005167_abnormal_blood-brain_barrier0.63380214
95MP0002102_abnormal_ear_morphology0.62230822
96MP0000604_amyloidosis0.61797326
97MP0003632_abnormal_nervous_system0.57946578
98MP0000026_abnormal_inner_ear0.57119878
99MP0005379_endocrine/exocrine_gland_phen0.56996945
100MP0002638_abnormal_pupillary_reflex0.56829793
101MP0010770_preweaning_lethality0.56649086
102MP0002082_postnatal_lethality0.56649086
103MP0001346_abnormal_lacrimal_gland0.56631509
104MP0010769_abnormal_survival0.54403524
105MP0003690_abnormal_glial_cell0.53167766
106MP0004233_abnormal_muscle_weight0.52209345
107MP0003861_abnormal_nervous_system0.51493255
108MP0010768_mortality/aging0.50897424
109MP0003956_abnormal_body_size0.50884379
110MP0004130_abnormal_muscle_cell0.45848730
111MP0003137_abnormal_impulse_conducting0.45408103
112MP0001765_abnormal_ion_homeostasis0.44170406

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.89176867
2Focal seizures (HP:0007359)5.51450678
3Visual hallucinations (HP:0002367)5.43514740
4Epileptic encephalopathy (HP:0200134)5.23151541
5Atonic seizures (HP:0010819)5.17650253
6Myokymia (HP:0002411)4.84912506
7Hyperventilation (HP:0002883)4.56958180
8Absence seizures (HP:0002121)4.55163039
9Febrile seizures (HP:0002373)4.34885656
10Dialeptic seizures (HP:0011146)4.15592686
11Generalized tonic-clonic seizures (HP:0002069)4.10779992
12Progressive cerebellar ataxia (HP:0002073)3.96182959
13Broad-based gait (HP:0002136)3.93193235
14Limb dystonia (HP:0002451)3.59702403
15Intention tremor (HP:0002080)3.58365190
16Excessive salivation (HP:0003781)3.38145684
17Drooling (HP:0002307)3.38145684
18Abnormal eating behavior (HP:0100738)3.24071503
19Polyphagia (HP:0002591)3.21766704
20Supranuclear gaze palsy (HP:0000605)3.11418110
21Impaired vibration sensation in the lower limbs (HP:0002166)3.09300180
22Truncal ataxia (HP:0002078)3.08572006
23Poor eye contact (HP:0000817)3.04739322
24Progressive inability to walk (HP:0002505)2.99291583
25Amblyopia (HP:0000646)2.97313047
26Annular pancreas (HP:0001734)2.90656989
27Gaze-evoked nystagmus (HP:0000640)2.90239065
28Depression (HP:0000716)2.87923726
29Failure to thrive in infancy (HP:0001531)2.84213355
30Obstructive sleep apnea (HP:0002870)2.84079794
31Ankle clonus (HP:0011448)2.83682342
32Anxiety (HP:0000739)2.83094408
33Tetraplegia (HP:0002445)2.77792583
34Dysdiadochokinesis (HP:0002075)2.74053412
35Papilledema (HP:0001085)2.73209135
36Cerebral hypomyelination (HP:0006808)2.72846547
37Neuronal loss in central nervous system (HP:0002529)2.69786121
38Mutism (HP:0002300)2.68129732
39Epileptiform EEG discharges (HP:0011182)2.66777713
40Protruding tongue (HP:0010808)2.65749268
41Impaired social interactions (HP:0000735)2.65727371
42Abnormal social behavior (HP:0012433)2.65727371
43Insidious onset (HP:0003587)2.63836633
44Termporal pattern (HP:0011008)2.63836633
45Hypoventilation (HP:0002791)2.63769540
46Agitation (HP:0000713)2.62148235
47Action tremor (HP:0002345)2.60684866
48Pheochromocytoma (HP:0002666)2.60311493
49Hemiparesis (HP:0001269)2.60061993
50Fetal akinesia sequence (HP:0001989)2.59945348
51Abnormal hair whorl (HP:0010721)2.58489902
52Urinary bladder sphincter dysfunction (HP:0002839)2.56864776
53Dysmetria (HP:0001310)2.56631362
54Neuroendocrine neoplasm (HP:0100634)2.54899237
55Abnormality of the corticospinal tract (HP:0002492)2.54775732
56Cerebral inclusion bodies (HP:0100314)2.51521353
57Inability to walk (HP:0002540)2.48518376
58Apathy (HP:0000741)2.46386271
59Delusions (HP:0000746)2.45623610
60Gait imbalance (HP:0002141)2.44143682
61EEG with generalized epileptiform discharges (HP:0011198)2.42433354
62Poor suck (HP:0002033)2.41474788
63Impaired smooth pursuit (HP:0007772)2.37289724
64Diplopia (HP:0000651)2.37021821
65Abnormality of binocular vision (HP:0011514)2.37021821
66Urinary urgency (HP:0000012)2.36925289
67Narrow nasal bridge (HP:0000446)2.36035288
68Rigidity (HP:0002063)2.33632236
69Abnormality of the labia minora (HP:0012880)2.30510533
70Incomplete penetrance (HP:0003829)2.30009949
71Absent speech (HP:0001344)2.29185389
72Abnormality of saccadic eye movements (HP:0000570)2.25686405
73Bradykinesia (HP:0002067)2.25598845
74Torticollis (HP:0000473)2.25519108
75Hypsarrhythmia (HP:0002521)2.25351171
76Spastic gait (HP:0002064)2.24759978
77Clonus (HP:0002169)2.24601657
78Abnormality of salivation (HP:0100755)2.24334954
79Increased circulating renin level (HP:0000848)2.23189860
80Postural instability (HP:0002172)2.23072714
81Generalized myoclonic seizures (HP:0002123)2.22494549
82Postural tremor (HP:0002174)2.22124638
83Genetic anticipation (HP:0003743)2.21839728
84Blue irides (HP:0000635)2.21504255
85Neurofibrillary tangles (HP:0002185)2.20836837
86Diminished motivation (HP:0000745)2.20741488
87Dysmetric saccades (HP:0000641)2.20333434
88Spastic tetraparesis (HP:0001285)2.19799173
89Oligomenorrhea (HP:0000876)2.19552718
90Specific learning disability (HP:0001328)2.16002693
91Scanning speech (HP:0002168)2.15133947
92Ventricular fibrillation (HP:0001663)2.14667269
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13318475
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.13318475
95Psychosis (HP:0000709)2.12486432
96Hemiplegia (HP:0002301)2.12342408
97Esotropia (HP:0000565)2.11643873
98Dynein arm defect of respiratory motile cilia (HP:0012255)2.08983357
99Absent/shortened dynein arms (HP:0200106)2.08983357
100Focal dystonia (HP:0004373)2.07006400
101Split foot (HP:0001839)2.05925585
102Stereotypic behavior (HP:0000733)2.05183261
103Status epilepticus (HP:0002133)2.05055307
104Sleep apnea (HP:0010535)2.04163417
105Acute necrotizing encephalopathy (HP:0006965)2.02265336
106Akinesia (HP:0002304)2.00933583
107Progressive macrocephaly (HP:0004481)2.00257368
108Hyperthyroidism (HP:0000836)2.00105181
109Congenital primary aphakia (HP:0007707)1.99287912
110Lower limb muscle weakness (HP:0007340)1.98491469
111Abnormality of ocular smooth pursuit (HP:0000617)1.96476368
112Generalized hypotonia (HP:0001290)1.96372573
113Impaired vibratory sensation (HP:0002495)1.96207459
114Craniofacial dystonia (HP:0012179)1.93274630
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91339406
116Gait ataxia (HP:0002066)1.90417169
117Abnormality of the lower motor neuron (HP:0002366)1.86762081
118Syncope (HP:0001279)1.86334429
119Peripheral hypomyelination (HP:0007182)1.83453470
120Choreoathetosis (HP:0001266)1.80622768
121Abnormal EKG (HP:0003115)1.79987389
122Prolonged QT interval (HP:0001657)1.79945556
123Bundle branch block (HP:0011710)1.78338394
124Rapidly progressive (HP:0003678)1.75951565
125Bronchomalacia (HP:0002780)1.75712414
126Memory impairment (HP:0002354)1.73558233
127Morphological abnormality of the pyramidal tract (HP:0002062)1.65788390
128Heterochromia iridis (HP:0001100)1.65709182
129Lower limb asymmetry (HP:0100559)1.65177633
130Renal salt wasting (HP:0000127)1.61839849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.67859329
2MAP3K123.89438125
3NTRK33.76406203
4MAP3K93.44762168
5MAP3K43.31126658
6MARK13.14722932
7EPHA42.99093886
8MAP2K72.78881931
9PINK12.77346732
10MINK12.42018982
11DAPK22.39681548
12CDK192.33528562
13MAP2K42.27018911
14NTRK22.21787780
15PLK22.12231607
16PAK61.85515965
17DAPK11.70407283
18PNCK1.69593701
19MAPK131.65102164
20GRK51.49042081
21KSR11.48212062
22KSR21.46173760
23ARAF1.46138108
24SIK21.45729830
25RIPK41.42807022
26NTRK11.41019060
27TNIK1.36431394
28OXSR11.32248144
29CDK51.31480205
30LATS21.20138209
31CCNB11.18938813
32PRKCG1.18384193
33CAMK2A1.18137625
34UHMK11.17169230
35WNK31.08802561
36AKT31.08774091
37CAMKK11.07765030
38MAP3K131.03701129
39FES1.00986178
40CAMK2B0.98186516
41CSNK1G20.97442664
42CDK180.94013925
43CAMKK20.92879690
44NEK60.92375226
45CAMK40.91544462
46CDK150.90386975
47CDK140.90184409
48PHKG20.88755348
49PHKG10.88755348
50NME10.88381138
51PRKD30.84067141
52PAK30.80481266
53CDK11A0.79595039
54SGK2230.77331026
55SGK4940.77331026
56GRK70.74906195
57PDK10.72671444
58TYRO30.72172085
59BCR0.69162190
60SGK20.68052864
61STK110.68020531
62RIPK10.67885075
63BRAF0.67443309
64BMPR20.66226768
65SCYL20.65632811
66MAP3K20.64477245
67CAMK2D0.64216526
68TSSK60.63834854
69ADRBK10.63347008
70STK380.63089950
71MAPKAPK50.62298666
72FGR0.60913456
73BRSK10.60786901
74PTK2B0.59759208
75SGK10.59719486
76INSRR0.58429717
77CSNK1G30.57871942
78PRPF4B0.56864463
79SIK30.56669399
80DYRK1A0.56526364
81CAMK2G0.56342374
82PDPK10.53883041
83PRKCE0.53832113
84RAF10.53761787
85PRKCH0.52044481
86CAMK10.49888658
87MAP3K60.48900194
88PKN10.47000401
89DAPK30.46253112
90ERBB30.45343874
91ALK0.43369336
92ADRBK20.42661157
93RET0.42143621
94MOS0.42028970
95FER0.41642325
96CAMK1D0.40941588
97TNK20.40563381
98ROCK20.40479420
99MAP3K10.40264688
100MAP3K110.39883017
101CAMK1G0.39484156
102PRKCA0.39421431
103RPS6KA30.38841626
104SGK30.37037945
105FRK0.34656431
106MAPK120.33679095
107PRKG20.33517652
108MARK20.33137182
109RPS6KA20.33040706
110PRKCZ0.33018981
111PRKG10.32217781
112MAPK100.31955399
113FYN0.31561578
114PRKACA0.31048419
115WNK10.30847989
116MUSK0.30413487
117MAP2K10.29757935
118CSNK1A10.28374348
119LIMK10.27122712
120PRKCB0.25591404

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.36860810
2Synaptic vesicle cycle_Homo sapiens_hsa047213.90442173
3GABAergic synapse_Homo sapiens_hsa047272.80770657
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77526127
5Amphetamine addiction_Homo sapiens_hsa050312.72019647
6Long-term potentiation_Homo sapiens_hsa047202.67596154
7Collecting duct acid secretion_Homo sapiens_hsa049662.52147198
8Circadian entrainment_Homo sapiens_hsa047132.47684051
9Glutamatergic synapse_Homo sapiens_hsa047242.47171800
10Morphine addiction_Homo sapiens_hsa050322.42716637
11Olfactory transduction_Homo sapiens_hsa047402.38265037
12Dopaminergic synapse_Homo sapiens_hsa047282.21017982
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02917759
14Insulin secretion_Homo sapiens_hsa049112.01877084
15Salivary secretion_Homo sapiens_hsa049702.01714940
16Cocaine addiction_Homo sapiens_hsa050301.99626742
17Taste transduction_Homo sapiens_hsa047421.94155553
18Serotonergic synapse_Homo sapiens_hsa047261.90228500
19Renin secretion_Homo sapiens_hsa049241.85853045
20Gastric acid secretion_Homo sapiens_hsa049711.81220826
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69275523
22Long-term depression_Homo sapiens_hsa047301.67432538
23Vibrio cholerae infection_Homo sapiens_hsa051101.65548806
24Cholinergic synapse_Homo sapiens_hsa047251.64652095
25Oxidative phosphorylation_Homo sapiens_hsa001901.61127573
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54909220
27Oxytocin signaling pathway_Homo sapiens_hsa049211.53683936
28Calcium signaling pathway_Homo sapiens_hsa040201.49411557
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48967211
30Vitamin B6 metabolism_Homo sapiens_hsa007501.45560971
31Cardiac muscle contraction_Homo sapiens_hsa042601.42015461
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40958011
33GnRH signaling pathway_Homo sapiens_hsa049121.31519494
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25951301
35Alzheimers disease_Homo sapiens_hsa050101.24470633
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23382088
37Gap junction_Homo sapiens_hsa045401.23374178
38Axon guidance_Homo sapiens_hsa043601.17131294
39Parkinsons disease_Homo sapiens_hsa050121.17075324
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14441479
41Estrogen signaling pathway_Homo sapiens_hsa049151.11888363
42cAMP signaling pathway_Homo sapiens_hsa040241.10359967
43Melanogenesis_Homo sapiens_hsa049160.99128548
44Phototransduction_Homo sapiens_hsa047440.97935124
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95641197
46ErbB signaling pathway_Homo sapiens_hsa040120.90945658
47Type II diabetes mellitus_Homo sapiens_hsa049300.89060341
48Oocyte meiosis_Homo sapiens_hsa041140.88788632
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84342265
50Dorso-ventral axis formation_Homo sapiens_hsa043200.83887396
51Glioma_Homo sapiens_hsa052140.83837409
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83208908
53Huntingtons disease_Homo sapiens_hsa050160.82953269
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81310161
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.80911671
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77799795
57Dilated cardiomyopathy_Homo sapiens_hsa054140.71533802
58MAPK signaling pathway_Homo sapiens_hsa040100.68737941
59Pancreatic secretion_Homo sapiens_hsa049720.68633930
60Thyroid hormone synthesis_Homo sapiens_hsa049180.60654955
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60176208
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60074023
63Alcoholism_Homo sapiens_hsa050340.58426558
64Rheumatoid arthritis_Homo sapiens_hsa053230.57578860
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56126050
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54441288
67Glucagon signaling pathway_Homo sapiens_hsa049220.53869485
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53800988
69Type I diabetes mellitus_Homo sapiens_hsa049400.52949022
70Prion diseases_Homo sapiens_hsa050200.52345886
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49953767
72Ras signaling pathway_Homo sapiens_hsa040140.49768750
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.48545883
74Mineral absorption_Homo sapiens_hsa049780.46097757
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.45481149
76Choline metabolism in cancer_Homo sapiens_hsa052310.45249104
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45166053
78Phagosome_Homo sapiens_hsa041450.43542226
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42461492
80Renal cell carcinoma_Homo sapiens_hsa052110.40849807
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39684985
82Wnt signaling pathway_Homo sapiens_hsa043100.38980136
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38231783
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37734704
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37658746
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36184536
87Ovarian steroidogenesis_Homo sapiens_hsa049130.34581468
88Nitrogen metabolism_Homo sapiens_hsa009100.33991806
89Rap1 signaling pathway_Homo sapiens_hsa040150.32903478
90Inositol phosphate metabolism_Homo sapiens_hsa005620.32350304
91Arginine biosynthesis_Homo sapiens_hsa002200.31559572
92African trypanosomiasis_Homo sapiens_hsa051430.30786434
93Bile secretion_Homo sapiens_hsa049760.30674826
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30556881
95Histidine metabolism_Homo sapiens_hsa003400.30480141
96Insulin signaling pathway_Homo sapiens_hsa049100.30430643
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29846494
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28620293
99Circadian rhythm_Homo sapiens_hsa047100.27845754
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27363142
101VEGF signaling pathway_Homo sapiens_hsa043700.26619786
102Hedgehog signaling pathway_Homo sapiens_hsa043400.25633839
103Butanoate metabolism_Homo sapiens_hsa006500.24299828
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.23888891
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23420989
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23118332
107Arginine and proline metabolism_Homo sapiens_hsa003300.22626615
108beta-Alanine metabolism_Homo sapiens_hsa004100.20208615
109Fatty acid biosynthesis_Homo sapiens_hsa000610.19457925
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19226813
111mTOR signaling pathway_Homo sapiens_hsa041500.19183404
112Endocytosis_Homo sapiens_hsa041440.18749759
113AMPK signaling pathway_Homo sapiens_hsa041520.18645889
114Tight junction_Homo sapiens_hsa045300.14888436
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13440156
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13340834
117ABC transporters_Homo sapiens_hsa020100.13287432

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