CBR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.55849347
2coenzyme catabolic process (GO:0009109)6.19618290
3sulfur amino acid catabolic process (GO:0000098)5.75955644
4cellular modified amino acid catabolic process (GO:0042219)5.74751414
5somite rostral/caudal axis specification (GO:0032525)5.67725408
6maintenance of protein location in nucleus (GO:0051457)5.60846028
7NADH metabolic process (GO:0006734)5.57886398
8negative regulation of epidermis development (GO:0045683)5.56461440
9hormone catabolic process (GO:0042447)5.32183948
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.10547569
11regulation of response to osmotic stress (GO:0047484)5.07441627
12negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.04494180
13response to dietary excess (GO:0002021)4.88819107
14phenol-containing compound catabolic process (GO:0019336)4.81127729
15epoxygenase P450 pathway (GO:0019373)4.81091340
16cellular glucuronidation (GO:0052695)4.81013683
17cytidine deamination (GO:0009972)4.80772198
18cytidine metabolic process (GO:0046087)4.80772198
19cytidine catabolic process (GO:0006216)4.80772198
20glucuronate metabolic process (GO:0019585)4.78169857
21uronic acid metabolic process (GO:0006063)4.78169857
22negative regulation of telomerase activity (GO:0051974)4.75492236
23rRNA transcription (GO:0009303)4.53282713
24muscle organ morphogenesis (GO:0048644)4.52658627
25negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.52574312
26negative regulation of epidermal cell differentiation (GO:0045605)4.52522792
27urea metabolic process (GO:0019627)4.52505006
28angiotensin maturation (GO:0002003)4.48080242
29glycoside metabolic process (GO:0016137)4.47764777
30negative regulation of cell cycle G2/M phase transition (GO:1902750)4.46540531
31nitrogen cycle metabolic process (GO:0071941)4.40092797
32urea cycle (GO:0000050)4.38655609
33regulation of MHC class I biosynthetic process (GO:0045343)4.36395441
34regulation of nuclear cell cycle DNA replication (GO:0033262)4.31308875
35regulation of cilium movement (GO:0003352)4.28827348
36L-ascorbic acid metabolic process (GO:0019852)4.19087712
37primary alcohol catabolic process (GO:0034310)4.18217073
38histone H4-K5 acetylation (GO:0043981)4.15755340
39histone H4-K8 acetylation (GO:0043982)4.15755340
40regulation of telomere maintenance via telomerase (GO:0032210)4.15400613
41fat-soluble vitamin biosynthetic process (GO:0042362)4.12104519
42nucleoside transmembrane transport (GO:1901642)4.07967257
43heme transport (GO:0015886)4.05520892
44regulation of apoptotic process involved in morphogenesis (GO:1902337)4.04752106
45biotin metabolic process (GO:0006768)4.04457944
46rRNA methylation (GO:0031167)4.03948807
47histone H4-K12 acetylation (GO:0043983)3.98060294
48* drug metabolic process (GO:0017144)3.97484503
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.96396418
50regulation of cholesterol esterification (GO:0010872)3.94264068
51notochord development (GO:0030903)3.91237039
52GDP-mannose metabolic process (GO:0019673)3.90983713
53cofactor catabolic process (GO:0051187)3.88219081
54primitive streak formation (GO:0090009)3.86691882
55transepithelial transport (GO:0070633)3.86435801
56phenylpropanoid metabolic process (GO:0009698)3.81763436
57vitamin A metabolic process (GO:0006776)3.77570751
58rRNA modification (GO:0000154)3.76376867
59flavonoid metabolic process (GO:0009812)3.75871363
60protein localization to kinetochore (GO:0034501)3.75564181
61cofactor transport (GO:0051181)3.73627419
62cullin deneddylation (GO:0010388)3.73217852
63bile acid metabolic process (GO:0008206)3.72267901
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.70917790
65fructose metabolic process (GO:0006000)3.69295290
66L-phenylalanine metabolic process (GO:0006558)3.65090797
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.65090797
68ethanol oxidation (GO:0006069)3.60584204
69nucleoside diphosphate biosynthetic process (GO:0009133)3.54993682
70positive regulation of cellular amine metabolic process (GO:0033240)3.53100482
71pyrimidine ribonucleoside catabolic process (GO:0046133)3.50153649
72omega-hydroxylase P450 pathway (GO:0097267)3.48810556
73glutamine family amino acid biosynthetic process (GO:0009084)3.46291589
74drug catabolic process (GO:0042737)3.45839130
75bile acid and bile salt transport (GO:0015721)3.39266360
76proline metabolic process (GO:0006560)3.37512277
77negative regulation of telomere maintenance (GO:0032205)3.37275589
78protein deneddylation (GO:0000338)3.37210005
79exogenous drug catabolic process (GO:0042738)3.37177864
80regulation of translation in response to stress (GO:0043555)3.37053478
81glyoxylate metabolic process (GO:0046487)3.36882639
82cardiovascular system development (GO:0072358)3.34864791
83branching involved in mammary gland duct morphogenesis (GO:0060444)3.32203258
84cysteine metabolic process (GO:0006534)3.31640443
85phospholipid efflux (GO:0033700)3.31175717
86intestinal absorption (GO:0050892)3.30965686
87xenobiotic catabolic process (GO:0042178)3.30105458
88mitochondrion distribution (GO:0048311)3.28896074
89L-phenylalanine catabolic process (GO:0006559)3.28537506
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28537506
91proline biosynthetic process (GO:0006561)3.27349658
92modified amino acid transport (GO:0072337)3.25272839
93intestinal epithelial cell development (GO:0060576)3.25219191
94positive regulation of triglyceride lipase activity (GO:0061365)3.24781237
95positive regulation of lipoprotein lipase activity (GO:0051006)3.24781237
96branched-chain amino acid catabolic process (GO:0009083)3.24312553
97ethanol metabolic process (GO:0006067)3.23587308
98* quinone metabolic process (GO:1901661)3.23204514
99maintenance of protein localization in organelle (GO:0072595)3.23111071
100very-low-density lipoprotein particle assembly (GO:0034379)3.23024993
101COPI coating of Golgi vesicle (GO:0048205)3.22856055
102Golgi transport vesicle coating (GO:0048200)3.22856055
103protein retention in ER lumen (GO:0006621)3.21997865
104protein maturation by protein folding (GO:0022417)3.20145760
105oxaloacetate metabolic process (GO:0006107)3.20012953
106interferon-gamma production (GO:0032609)3.19299300
107proline transport (GO:0015824)3.18970135
108aromatic amino acid family catabolic process (GO:0009074)3.17057754
109positive regulation of DNA-dependent DNA replication (GO:2000105)3.15937179
110cellular aldehyde metabolic process (GO:0006081)3.15164362
111thyroid hormone generation (GO:0006590)3.14476421
112valine metabolic process (GO:0006573)3.11585111
113cell fate commitment involved in formation of primary germ layer (GO:0060795)3.11210768
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08338741
115mitotic sister chromatid segregation (GO:0000070)3.08131506
116kynurenine metabolic process (GO:0070189)3.06807162
117bile acid biosynthetic process (GO:0006699)3.06301073
118icosanoid secretion (GO:0032309)3.05372355
119arachidonic acid secretion (GO:0050482)3.05372355
120transcription from mitochondrial promoter (GO:0006390)3.03982342
121indole-containing compound catabolic process (GO:0042436)3.02557628
122indolalkylamine catabolic process (GO:0046218)3.02557628
123tryptophan catabolic process (GO:0006569)3.02557628
124regulation of triglyceride catabolic process (GO:0010896)3.01860268
125serine family amino acid catabolic process (GO:0009071)3.01594934
126DNA damage response, detection of DNA damage (GO:0042769)3.00802197
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99989151
128cellular response to cadmium ion (GO:0071276)2.99684971
129nucleoside transport (GO:0015858)2.99224793
130retinoic acid receptor signaling pathway (GO:0048384)2.97534516
131regulation of bile acid biosynthetic process (GO:0070857)2.96839447
132cellular amino acid catabolic process (GO:0009063)2.95209000
133organic cation transport (GO:0015695)2.94219963
134regulation of telomerase activity (GO:0051972)2.94035818
135tricarboxylic acid cycle (GO:0006099)2.93802376
136pteridine-containing compound biosynthetic process (GO:0042559)2.92842476
137lipoprotein transport (GO:0042953)2.91531284
138regulation of guanylate cyclase activity (GO:0031282)2.91117988
139progesterone metabolic process (GO:0042448)2.90075179
140maternal placenta development (GO:0001893)2.90009375
141regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.88361522
142* cyclooxygenase pathway (GO:0019371)2.87712666
143glycolipid catabolic process (GO:0019377)2.87060962
144nucleotide-sugar biosynthetic process (GO:0009226)2.86974829
145negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86932927
146receptor recycling (GO:0001881)2.86753660
147heterochromatin organization (GO:0070828)2.86443164
148glutathione derivative biosynthetic process (GO:1901687)2.84108529
149glutathione derivative metabolic process (GO:1901685)2.84108529
150vitamin biosynthetic process (GO:0009110)2.82231511
151nucleobase-containing small molecule interconversion (GO:0015949)2.81455112
152very long-chain fatty acid metabolic process (GO:0000038)2.79165492
153fibrinolysis (GO:0042730)2.78501500
154glycosphingolipid catabolic process (GO:0046479)2.77958408
155regulation of cholesterol metabolic process (GO:0090181)2.77387413
156virion attachment to host cell (GO:0019062)2.76869797
157adhesion of symbiont to host cell (GO:0044650)2.76869797
158primary alcohol metabolic process (GO:0034308)2.75590600
159cellular copper ion homeostasis (GO:0006878)2.71243739
160regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70082410
161aldehyde catabolic process (GO:0046185)2.69657714
162glutathione metabolic process (GO:0006749)2.65935553
163plasma lipoprotein particle assembly (GO:0034377)2.63991145
164protein-lipid complex assembly (GO:0065005)2.63290598
165retinal metabolic process (GO:0042574)2.60357252
166regulation of cellular amino acid metabolic process (GO:0006521)2.59790744
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.58211358
168proteasome assembly (GO:0043248)2.57746696
169cellular response to zinc ion (GO:0071294)2.57101633
170adhesion of symbiont to host (GO:0044406)2.56000913
171renal system process involved in regulation of blood volume (GO:0001977)2.55107636
172regulation of protein activation cascade (GO:2000257)2.54304874
173monosaccharide biosynthetic process (GO:0046364)2.53595673
174arginine metabolic process (GO:0006525)2.53397010
175negative regulation of response to reactive oxygen species (GO:1901032)2.51919949
176glutathione biosynthetic process (GO:0006750)2.51884597
177daunorubicin metabolic process (GO:0044597)10.5718105
178polyketide metabolic process (GO:0030638)10.5718105
179doxorubicin metabolic process (GO:0044598)10.5718105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.44648138
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.44648138
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.44648138
4* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00209432
5NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.45277207
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.27332357
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.14027796
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05108735
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.03923578
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87710263
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.74216831
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71568766
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.65858720
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.61237356
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.59626381
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.59319013
17NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.54490505
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50850647
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48129037
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42647067
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.31403012
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.29490827
23NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.27695760
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26741748
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25678014
26IRF1_19129219_ChIP-ChIP_H3396_Human2.22486187
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.21907049
28* RXR_22158963_ChIP-Seq_LIVER_Mouse2.13412997
29ZNF263_19887448_ChIP-Seq_K562_Human2.03483710
30STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02477144
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99524820
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.96950485
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95457481
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.92577012
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90255230
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86022372
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80920255
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.80633835
39AR_21909140_ChIP-Seq_LNCAP_Human1.76190987
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73804241
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73680190
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.71809986
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71429838
44NANOG_18692474_ChIP-Seq_MEFs_Mouse1.68456838
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68249433
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.65005886
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62643028
48* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.62406843
49CLOCK_20551151_ChIP-Seq_293T_Human1.59244284
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58390437
51* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.54520721
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53952579
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50878746
54SOX2_18692474_ChIP-Seq_MEFs_Mouse1.49287036
55NANOG_18692474_ChIP-Seq_MESCs_Mouse1.48405397
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48404941
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.48087290
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42498200
59E2F1_17053090_ChIP-ChIP_MCF-7_Human1.42024910
60* SOX2_20726797_ChIP-Seq_SW620_Human1.40253251
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38108586
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37542811
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35242243
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35211995
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33733663
66SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31321285
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30211194
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29544312
69NANOG_16518401_ChIP-PET_MESCs_Mouse1.28157115
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.27195051
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25660432
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25011949
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24567528
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23542391
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22849241
76GATA6_25053715_ChIP-Seq_YYC3_Human1.21277364
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21219570
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20956687
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.19467705
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19466222
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19067599
82DCP1A_22483619_ChIP-Seq_HELA_Human1.18369025
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.17510841
84* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16077764
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15486545
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15363431
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.15120035
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15078714
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.14724349
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14307360
91GATA4_25053715_ChIP-Seq_YYC3_Human1.13813325
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13719492
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13156368
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12575674
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11930314
96ATF3_27146783_Chip-Seq_COLON_Human1.11058241
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10778252
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10646289
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09035593
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08556143
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07971279
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07408277
103XRN2_22483619_ChIP-Seq_HELA_Human1.07292298
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05958178
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.04531663
106* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04491970
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03967058
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03732239
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.03601058
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03421904
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02927613
112CTCF_20526341_ChIP-Seq_ESCs_Human1.02330706
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01786456
114TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01415383
115SA1_27219007_Chip-Seq_Bcells_Human1.00197812
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99311330
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.99245739
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.97837881
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97761682
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97277738
121SMC4_20622854_ChIP-Seq_HELA_Human0.97266995
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96574952
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96045064
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95655076
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95485398
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.94797555
127* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94254793
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91393726
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89760831
130LXR_22292898_ChIP-Seq_THP-1_Human0.89540736
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.89163470
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88671525
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88280589
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87957637
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87605057
136E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87468171
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.83932465
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83663834
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83336102
140RACK7_27058665_Chip-Seq_MCF-7_Human0.83092441
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82703713
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.81444946
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81424713
144TP53_22127205_ChIP-Seq_IMR90_Human0.81033020
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80767545
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79248904
147BCOR_27268052_Chip-Seq_Bcells_Human0.77962323
148KAP1_27257070_Chip-Seq_ESCs_Mouse0.77693175
149SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77572406
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.76798746
151EOMES_21245162_ChIP-Seq_HESCs_Human0.76464142
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.76266061
153P68_20966046_ChIP-Seq_HELA_Human0.76121347
154CTCF_21964334_Chip-Seq_Bcells_Human0.76115202
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76005521
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.75673887
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.75437808
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.72694507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.07847197
2MP0004264_abnormal_extraembryonic_tissu4.37326078
3MP0002254_reproductive_system_inflammat4.26337495
4MP0005360_urolithiasis4.02389468
5MP0006292_abnormal_olfactory_placode3.80189727
6MP0002139_abnormal_hepatobiliary_system3.60013787
7MP0008875_abnormal_xenobiotic_pharmacok3.40381221
8MP0005394_taste/olfaction_phenotype3.25100768
9MP0005499_abnormal_olfactory_system3.25100768
10MP0004858_abnormal_nervous_system3.11209481
11MP0006035_abnormal_mitochondrial_morpho2.83476553
12MP0003890_abnormal_embryonic-extraembry2.82282254
13MP0003122_maternal_imprinting2.77092217
14MP0005365_abnormal_bile_salt2.77071087
15MP0005085_abnormal_gallbladder_physiolo2.73923522
16MP0002332_abnormal_exercise_endurance2.57107297
17MP0004043_abnormal_pH_regulation2.57011762
18MP0005075_abnormal_melanosome_morpholog2.54031009
19MP0009379_abnormal_foot_pigmentation2.43421035
20MP0005058_abnormal_lysosome_morphology2.29642815
21MP0003806_abnormal_nucleotide_metabolis2.24005980
22MP0010234_abnormal_vibrissa_follicle2.18936062
23MP0000678_abnormal_parathyroid_gland2.07770200
24MP0002653_abnormal_ependyma_morphology2.06125171
25MP0005257_abnormal_intraocular_pressure1.80343169
26MP0009697_abnormal_copulation1.77574105
27MP0008961_abnormal_basal_metabolism1.76369255
28MP0003183_abnormal_peptide_metabolism1.75730026
29MP0003705_abnormal_hypodermis_morpholog1.73836395
30MP0005332_abnormal_amino_acid1.72412587
31MP0008260_abnormal_autophagy1.71087472
32MP0004019_abnormal_vitamin_homeostasis1.68382230
33MP0004957_abnormal_blastocyst_morpholog1.65422093
34MP0001764_abnormal_homeostasis1.64783431
35MP0003938_abnormal_ear_development1.64462853
36MP0005266_abnormal_metabolism1.63618936
37MP0003941_abnormal_skin_development1.54817754
38MP0008789_abnormal_olfactory_epithelium1.53431142
39MP0010030_abnormal_orbit_morphology1.48176871
40MP0003121_genomic_imprinting1.47994097
41MP0010329_abnormal_lipoprotein_level1.47290674
42MP0005319_abnormal_enzyme/_coenzyme1.43555196
43MP0003252_abnormal_bile_duct1.40302036
44MP0005451_abnormal_body_composition1.40079422
45MP0004147_increased_porphyrin_level1.39780163
46MP0005166_decreased_susceptibility_to1.38570339
47MP0005408_hypopigmentation1.37851666
48MP0002277_abnormal_respiratory_mucosa1.36979811
49MP0005501_abnormal_skin_physiology1.36296671
50MP0002127_abnormal_cardiovascular_syste1.34155831
51MP0005670_abnormal_white_adipose1.31484613
52MP0003329_amyloid_beta_deposits1.31410049
53MP0006036_abnormal_mitochondrial_physio1.31021386
54MP0005165_increased_susceptibility_to1.30807754
55MP0001666_abnormal_nutrient_absorption1.30362310
56MP0002132_abnormal_respiratory_system1.27701042
57MP0003186_abnormal_redox_activity1.27072553
58MP0003075_altered_response_to1.26141119
59MP0002877_abnormal_melanocyte_morpholog1.25233851
60MP0000920_abnormal_myelination1.24275485
61MP0000762_abnormal_tongue_morphology1.20271336
62MP0003718_maternal_effect1.19496426
63MP0008438_abnormal_cutaneous_collagen1.19122099
64MP0000604_amyloidosis1.18540710
65MP0000049_abnormal_middle_ear1.18283547
66MP0003283_abnormal_digestive_organ1.18215399
67MP0002932_abnormal_joint_morphology1.17197637
68MP0005023_abnormal_wound_healing1.16519052
69MP0008872_abnormal_physiological_respon1.15518528
70MP0003315_abnormal_perineum_morphology1.14210892
71MP0004272_abnormal_basement_membrane1.12814513
72MP0001849_ear_inflammation1.10417656
73MP0002876_abnormal_thyroid_physiology1.09683450
74MP0000609_abnormal_liver_physiology1.09604622
75MP0001672_abnormal_embryogenesis/_devel1.08485294
76MP0005380_embryogenesis_phenotype1.08485294
77MP0009840_abnormal_foam_cell1.04733108
78MP0006082_CNS_inflammation1.03739702
79MP0008057_abnormal_DNA_replication1.03339171
80MP0002088_abnormal_embryonic_growth/wei1.01584599
81MP0003123_paternal_imprinting1.01301459
82MP0002970_abnormal_white_adipose1.00207491
83MP0010352_gastrointestinal_tract_polyps0.98600038
84MP0001293_anophthalmia0.98181945
85MP0003984_embryonic_growth_retardation0.98127091
86MP0002233_abnormal_nose_morphology0.97796656
87MP0002092_abnormal_eye_morphology0.97082055
88MP0005248_abnormal_Harderian_gland0.95947578
89MP0003453_abnormal_keratinocyte_physiol0.94078840
90MP0010155_abnormal_intestine_physiology0.94029290
91MP0005376_homeostasis/metabolism_phenot0.93770330
92MP0009643_abnormal_urine_homeostasis0.93730253
93MP0003119_abnormal_digestive_system0.93302394
94MP0003879_abnormal_hair_cell0.90723308
95MP0000537_abnormal_urethra_morphology0.90277027
96MP0005083_abnormal_biliary_tract0.88954323
97MP0000579_abnormal_nail_morphology0.88563061
98MP0003566_abnormal_cell_adhesion0.87610608
99MP0000467_abnormal_esophagus_morphology0.87333258
100MP0001664_abnormal_digestion0.86262660
101MP0000462_abnormal_digestive_system0.84572233
102MP0003191_abnormal_cellular_cholesterol0.84308326
103MP0004133_heterotaxia0.83702424
104MP0000538_abnormal_urinary_bladder0.82946342
105MP0003137_abnormal_impulse_conducting0.82031320
106MP0005623_abnormal_meninges_morphology0.81677133
107MP0003950_abnormal_plasma_membrane0.79969734
108MP0000858_altered_metastatic_potential0.79524701
109MP0009780_abnormal_chondrocyte_physiolo0.78454235
110MP0001216_abnormal_epidermal_layer0.76235641
111MP0002909_abnormal_adrenal_gland0.75763415
112MP0002138_abnormal_hepatobiliary_system0.75705636
113MP0005584_abnormal_enzyme/coenzyme_acti0.74219393
114MP0001188_hyperpigmentation0.74084661
115MP0002060_abnormal_skin_morphology0.73951202
116MP0002136_abnormal_kidney_physiology0.73269007
117MP0005636_abnormal_mineral_homeostasis0.73071833
118MP0002249_abnormal_larynx_morphology0.72894475
119MP0009333_abnormal_splenocyte_physiolog0.72144073
120MP0000343_altered_response_to0.71378620
121MP0002114_abnormal_axial_skeleton0.71204475
122MP0003638_abnormal_response/metabolism_0.71051594
123MP0005395_other_phenotype0.70498257
124MP0000477_abnormal_intestine_morphology0.69430420
125MP0000681_abnormal_thyroid_gland0.69225064
126MP0001243_abnormal_dermal_layer0.69207756
127MP0002751_abnormal_autonomic_nervous0.69158406
128MP0002118_abnormal_lipid_homeostasis0.67979978
129MP0001881_abnormal_mammary_gland0.67040499
130MP0004142_abnormal_muscle_tone0.65717443
131MP0008469_abnormal_protein_level0.65111405
132MP0001756_abnormal_urination0.64684856
133MP0003195_calcinosis0.63690069
134MP0000358_abnormal_cell_content/0.62805683
135MP0003866_abnormal_defecation0.62463374
136MP0002086_abnormal_extraembryonic_tissu0.61861613
137MP0004883_abnormal_blood_vessel0.61840601
138MP0010771_integument_phenotype0.61386026
139MP0010386_abnormal_urinary_bladder0.60966744
140MP0004270_analgesia0.59996961
141MP0009763_increased_sensitivity_to0.59430646
142MP0002085_abnormal_embryonic_tissue0.58816708
143MP0002098_abnormal_vibrissa_morphology0.58735695
144MP0000598_abnormal_liver_morphology0.58020341
145MP0008770_decreased_survivor_rate0.55337907
146MP0005330_cardiomyopathy0.55006465
147MP0002796_impaired_skin_barrier0.54957771
148MP0005391_vision/eye_phenotype0.54310070
149MP0003693_abnormal_embryo_hatching0.54101618
150MP0003690_abnormal_glial_cell0.53884517
151MP0009642_abnormal_blood_homeostasis0.53817614
152MP0003755_abnormal_palate_morphology0.53462330
153MP0001348_abnormal_lacrimal_gland0.53062007
154MP0000350_abnormal_cell_proliferation0.52914832
155MP0004782_abnormal_surfactant_physiolog0.51968327
156MP0009115_abnormal_fat_cell0.51627823
157MP0002269_muscular_atrophy0.50823312
158MP0002822_catalepsy0.48032759
159MP0001270_distended_abdomen0.47915797
160MP0003868_abnormal_feces_composition0.47730057
161MP0000490_abnormal_crypts_of0.47188790

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.84814061
2Hypochromic microcytic anemia (HP:0004840)6.36865167
3Multiple enchondromatosis (HP:0005701)5.58555993
4Hepatoblastoma (HP:0002884)5.56081144
5Abnormality of the lower motor neuron (HP:0002366)4.73398140
6Hypobetalipoproteinemia (HP:0003563)4.61048188
7Systemic lupus erythematosus (HP:0002725)4.54620752
8Hydroxyprolinuria (HP:0003080)4.17470249
9Abnormality of proline metabolism (HP:0010907)4.17470249
10Hyperglycinuria (HP:0003108)3.94503394
11Rib fusion (HP:0000902)3.82384307
12Abnormal cartilage morphology (HP:0002763)3.82375650
13Ragged-red muscle fibers (HP:0003200)3.81048238
14Gout (HP:0001997)3.69264811
15Fat malabsorption (HP:0002630)3.67070904
16Hyperinsulinemic hypoglycemia (HP:0000825)3.59692807
17Hyperventilation (HP:0002883)3.56778192
18Malnutrition (HP:0004395)3.52058655
19Testicular atrophy (HP:0000029)3.29211144
20Neoplasm of striated muscle (HP:0009728)3.28536376
21Ependymoma (HP:0002888)3.22562605
22Reduced antithrombin III activity (HP:0001976)3.22055238
23Rhabdomyosarcoma (HP:0002859)3.21856562
24Steatorrhea (HP:0002570)3.16005434
25Complement deficiency (HP:0004431)3.10802103
26Abnormality of complement system (HP:0005339)3.07116651
27Hypoplasia of the fovea (HP:0007750)3.05171856
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.05171856
29Abnormality of serine family amino acid metabolism (HP:0010894)3.03593908
30Abnormality of glycine metabolism (HP:0010895)3.03593908
31Partial duplication of thumb phalanx (HP:0009944)3.03450060
32Abnormality of the intrinsic pathway (HP:0010989)3.01600306
33Vaginal fistula (HP:0004320)3.01555490
34Abnormality of glycolysis (HP:0004366)3.00573079
35Increased serum pyruvate (HP:0003542)3.00573079
36Anomalous pulmonary venous return (HP:0010772)2.94886000
37Vertebral compression fractures (HP:0002953)2.91803738
38Hypolipoproteinemia (HP:0010981)2.89726738
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87571125
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87571125
41Rectal fistula (HP:0100590)2.86801487
42Rectovaginal fistula (HP:0000143)2.86801487
43Nephroblastoma (Wilms tumor) (HP:0002667)2.84793913
44Deep venous thrombosis (HP:0002625)2.81697357
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.80123221
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.75799542
473-Methylglutaconic aciduria (HP:0003535)2.74661167
48Amyotrophic lateral sclerosis (HP:0007354)2.70884634
49Prolonged partial thromboplastin time (HP:0003645)2.70494579
50Embryonal renal neoplasm (HP:0011794)2.69075253
51Bifid tongue (HP:0010297)2.64721611
52Partial duplication of the phalanx of hand (HP:0009999)2.63423280
53Nausea (HP:0002018)2.62408443
54Tetraplegia (HP:0002445)2.60576759
55Abnormality of the pulmonary veins (HP:0011718)2.51092803
56Fused cervical vertebrae (HP:0002949)2.50837079
57Axonal loss (HP:0003447)2.49928785
58Glomerulonephritis (HP:0000099)2.49412424
59Generalized hypotonia (HP:0001290)2.48530121
60Cholecystitis (HP:0001082)2.48331672
61Abnormal gallbladder physiology (HP:0012438)2.48331672
62Progressive muscle weakness (HP:0003323)2.48097945
63Abnormality of vitamin metabolism (HP:0100508)2.47795539
64Skin nodule (HP:0200036)2.47767337
65Hypochromic anemia (HP:0001931)2.47708103
66Trismus (HP:0000211)2.47694905
67Abnormality of pyrimidine metabolism (HP:0004353)2.46128569
68Horizontal nystagmus (HP:0000666)2.44777718
69Abnormality of the salivary glands (HP:0010286)2.43586687
70Confusion (HP:0001289)2.43137649
71Cerebral edema (HP:0002181)2.40907997
72Hyperammonemia (HP:0001987)2.39268062
73Conjugated hyperbilirubinemia (HP:0002908)2.38857843
74Ileus (HP:0002595)2.37784658
75Intestinal fistula (HP:0100819)2.37692037
76Abnormality of the fovea (HP:0000493)2.36834290
77Vascular calcification (HP:0004934)2.36137775
78Aplasia/hypoplasia of the humerus (HP:0006507)2.33930110
79Abnormality of urine glucose concentration (HP:0011016)2.33671620
80Glycosuria (HP:0003076)2.33671620
81Abnormal mitochondria in muscle tissue (HP:0008316)2.33022650
82Shawl scrotum (HP:0000049)2.32006585
83Stridor (HP:0010307)2.31840774
84Acute encephalopathy (HP:0006846)2.27878680
85Ketoacidosis (HP:0001993)2.27362116
86Nasolacrimal duct obstruction (HP:0000579)2.27296826
87Abnormality of nucleobase metabolism (HP:0010932)2.26619272
88Sensory axonal neuropathy (HP:0003390)2.26539260
89Abnormality of the phalanges of the hallux (HP:0010057)2.26300873
90Generalized aminoaciduria (HP:0002909)2.26193339
91Short humerus (HP:0005792)2.26047298
92Progressive external ophthalmoplegia (HP:0000590)2.25777590
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24117151
94Prolonged neonatal jaundice (HP:0006579)2.22670213
95Hyperglycinemia (HP:0002154)2.22524097
96Posterior subcapsular cataract (HP:0007787)2.19719390
97Paraparesis (HP:0002385)2.19309958
98Megaloblastic anemia (HP:0001889)2.18776172
99Microvesicular hepatic steatosis (HP:0001414)2.18565893
100Cardiovascular calcification (HP:0011915)2.17771769
101Abnormality of purine metabolism (HP:0004352)2.17677511
102Intrahepatic cholestasis (HP:0001406)2.17461506
103Patchy hypopigmentation of hair (HP:0011365)2.17391113
104Preauricular pit (HP:0004467)2.17308237
105Periauricular skin pits (HP:0100277)2.17308237
106Abnormal lung lobation (HP:0002101)2.16122934
107Abnormality of the vitamin B12 metabolism (HP:0004341)2.14803804
108Hyperparathyroidism (HP:0000843)2.13687295
109Microretrognathia (HP:0000308)2.13112306
110Hyperactive renin-angiotensin system (HP:0000841)2.12707822
111Hyperuricemia (HP:0002149)2.12221549
112Increased purine levels (HP:0004368)2.12221549
113Abnormality of serum amino acid levels (HP:0003112)2.12150859
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10929182
115Xanthomatosis (HP:0000991)2.10537478
116Abnormality of small intestinal villus morphology (HP:0011472)2.09407612
117Villous atrophy (HP:0011473)2.09407612
118Ketosis (HP:0001946)2.07101723
119Impulsivity (HP:0100710)2.06031327
120Upper motor neuron abnormality (HP:0002127)2.03820936
121Osteolytic defects of the hand bones (HP:0009699)2.03728138
122Osteolytic defects of the phalanges of the hand (HP:0009771)2.03728138
123Abnormality of the Achilles tendon (HP:0005109)2.03179927
124Dicarboxylic aciduria (HP:0003215)2.02825842
125Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02825842
126Large earlobe (HP:0009748)2.02441423
127Vacuolated lymphocytes (HP:0001922)2.02070341
128Abnormality of the astrocytes (HP:0100707)2.01807967
129Astrocytoma (HP:0009592)2.01807967
130Hyperphosphaturia (HP:0003109)2.01683301
131Metabolic acidosis (HP:0001942)2.01503136
132Pseudobulbar signs (HP:0002200)2.00916646
133Tongue fasciculations (HP:0001308)2.00384420
134Aplasia/Hypoplasia of the macula (HP:0008059)1.99641572
135Preauricular skin tag (HP:0000384)1.98235849
136Abnormality of sulfur amino acid metabolism (HP:0004339)1.98134202
137Amyloidosis (HP:0011034)1.97889260
138Status epilepticus (HP:0002133)1.97250177
139Nephrolithiasis (HP:0000787)1.97211745
140Proximal tubulopathy (HP:0000114)1.96054240
141Abnormality of the distal phalanges of the toes (HP:0010182)1.95233154
142Abnormality of methionine metabolism (HP:0010901)1.95210933
143Increased intramyocellular lipid droplets (HP:0012240)1.94891126
144Cheilitis (HP:0100825)1.94722165
145Abnormality of liposaccharide metabolism (HP:0010968)1.94571213
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.94571213
147Abnormality of glycolipid metabolism (HP:0010969)1.94571213
148Acute necrotizing encephalopathy (HP:0006965)1.93917388
149Increased muscle lipid content (HP:0009058)1.92779946
150Abnormal hair laboratory examination (HP:0003328)1.92376087
151Amblyopia (HP:0000646)1.92221163
152Vomiting (HP:0002013)1.91842672
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91682320
154Alkalosis (HP:0001948)1.91346028
155Hepatic necrosis (HP:0002605)1.90667059
156Sparse eyelashes (HP:0000653)1.89981488
157Irritability (HP:0000737)1.89513759
158Abnormality of vitamin B metabolism (HP:0004340)1.89009792
159Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88411335
160Type I transferrin isoform profile (HP:0003642)1.88034025
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87893612
162Multiple lipomas (HP:0001012)1.87367604
163Lethargy (HP:0001254)1.86438261
164Hypokinesia (HP:0002375)1.86389664
165Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85739493
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.83756094
167White forelock (HP:0002211)1.83053096
168Achilles tendon contracture (HP:0001771)1.82722998
169Abnormal biliary tract physiology (HP:0012439)1.82325696
170Bile duct proliferation (HP:0001408)1.82325696
171Neoplasm of the heart (HP:0100544)1.81709393
172Spastic tetraparesis (HP:0001285)1.81628607
173Rough bone trabeculation (HP:0100670)1.81173905
174Spastic paraparesis (HP:0002313)1.80040630
175Abnormality of fatty-acid metabolism (HP:0004359)1.78878272
176Nephritis (HP:0000123)1.78521829
177Premature rupture of membranes (HP:0001788)1.77962075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.95629498
2GRK55.86569976
3ERN15.16985706
4GRK64.88320974
5NME23.63286327
6TESK13.60002994
7PBK3.47438102
8ADRBK23.42807565
9GRK13.32945488
10ARAF3.17104873
11MAP3K122.76819007
12TGFBR22.70577225
13GRK72.63052055
14CSF1R2.60230745
15LIMK12.55494929
16TYRO32.47812898
17MATK2.38570688
18MAPK72.38161139
19PIM22.27350920
20TTK2.15890453
21IRAK32.12436349
22RIPK12.04722942
23MYLK2.01159315
24MOS1.98064077
25WNK11.86705947
26VRK21.85111630
27PRKG21.80467263
28MET1.79542920
29MAP2K41.78754081
30BCKDK1.72650160
31EIF2AK11.71293802
32NTRK11.69737420
33MAP3K31.65705804
34STK101.65417256
35CAMK41.60024831
36DAPK11.52588426
37AKT31.48828393
38ACVR1B1.38644957
39ADRBK11.36941979
40EPHA21.30305574
41ILK1.29754474
42CAMK2G1.28189548
43SMG11.27876477
44MARK21.22621162
45WNK31.21934350
46CDK71.20016236
47PAK41.18563580
48MAP2K61.16758746
49STK161.16398173
50DAPK31.13584552
51SCYL21.11114291
52MAPKAPK51.05523091
53MAP3K111.03580900
54BRAF1.01904673
55BRSK10.96413014
56MAP3K70.93521192
57HIPK20.92157800
58MAP3K20.91935066
59PAK60.80408341
60CAMK2B0.79867305
61CHEK20.78390029
62TBK10.76877999
63MAPK120.76692505
64CAMK2D0.74260002
65LATS20.73443845
66AKT20.72331699
67PRKCI0.71310721
68PLK10.70787504
69FGFR30.69951591
70MAP3K90.68645191
71DDR20.68525111
72KDR0.68067618
73MAP3K10.65541586
74LRRK20.64376992
75PDPK10.63440707
76MAP3K80.59882669
77OXSR10.57513793
78NME10.56957038
79DYRK20.55688937
80CSK0.55444857
81MAP3K100.53337746
82PRPF4B0.52818362
83MST40.52789845
84CSNK1G30.52607546
85ERBB20.50903010
86PDGFRA0.49780827
87PTK20.48712810
88FGFR40.48435176
89ROCK20.46246696
90AURKB0.43352290
91TRIB30.43297326
92AURKA0.42296007
93PRKCG0.41067504
94FER0.40690411
95MAPK40.40301889
96IGF1R0.39992501
97SIK10.38950020
98EPHB10.37597855
99MST1R0.37567441
100PRKCD0.37513671
101MAPK110.37201716
102NEK10.36073072
103PRKACG0.35668882
104PAK20.35043190
105EIF2AK20.34102602
106MINK10.34019970
107TAOK20.33851444
108CSNK1E0.33625147
109DYRK1A0.33084259
110PRKD30.33048392
111ALK0.32573608
112PRKCA0.32429693
113PAK10.31337802
114EIF2AK30.30257889
115NEK60.29853507
116BMX0.28710261
117STK380.27919902
118CHEK10.27879835
119TYK20.27745365
120PDK30.27395871
121PDK40.27395871
122PRKAA10.27291453
123PAK30.26486568
124FLT30.26274834
125PRKACA0.26139015
126ERBB40.26088185
127EPHA40.25787708
128BUB10.25346933
129SRC0.24919627
130DYRK1B0.24813023
131CDK150.24408865
132PTK60.24272829
133CSNK1A1L0.23478568
134CSNK2A10.23452814
135KSR20.23369570
136CDK180.22823723
137CDK11A0.21930261
138GSK3A0.21853820
139WNK40.21787819
140MTOR0.21683128
141MAP2K20.21572263
142UHMK10.21345512
143SRPK10.21341261
144TAOK10.20363462
145LMTK20.19791049
146CDK190.19254241
147PRKACB0.18522725
148TESK20.18411883
149MAPKAPK30.17332223
150PDK20.17288265
151CDK20.16728236
152PRKD20.16641900
153CDK140.16256154
154ABL20.15841726
155CASK0.13684270
156DAPK20.13448640
157INSR0.12150731
158NTRK20.11047456
159DYRK30.11031445
160STK38L0.10721384
161RPS6KB20.10008834
162EPHB20.09849827
163MAPK100.09142586

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.27820344
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.59416086
3Fructose and mannose metabolism_Homo sapiens_hsa000513.22803521
4Pentose and glucuronate interconversions_Homo sapiens_hsa000403.19318989
5* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.68219552
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60337444
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43519144
8Tryptophan metabolism_Homo sapiens_hsa003802.43445419
9Galactose metabolism_Homo sapiens_hsa000522.39985976
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20950195
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20078661
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.14534966
13Proteasome_Homo sapiens_hsa030501.99627128
14Sulfur relay system_Homo sapiens_hsa041221.96074869
15Folate biosynthesis_Homo sapiens_hsa007901.90329329
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85767983
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85350759
18* Chemical carcinogenesis_Homo sapiens_hsa052041.77942238
19Butanoate metabolism_Homo sapiens_hsa006501.74208672
20Fatty acid degradation_Homo sapiens_hsa000711.64769237
21Arginine biosynthesis_Homo sapiens_hsa002201.63194594
22Sulfur metabolism_Homo sapiens_hsa009201.59323471
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57052413
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54831424
25Carbon metabolism_Homo sapiens_hsa012001.53148543
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53017012
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51501470
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48096974
29Peroxisome_Homo sapiens_hsa041461.47622339
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45358398
31Linoleic acid metabolism_Homo sapiens_hsa005911.45198433
32PPAR signaling pathway_Homo sapiens_hsa033201.40896752
33Bile secretion_Homo sapiens_hsa049761.35450604
34Retinol metabolism_Homo sapiens_hsa008301.35274075
35Complement and coagulation cascades_Homo sapiens_hsa046101.34312611
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33408410
37Propanoate metabolism_Homo sapiens_hsa006401.30306703
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.29970215
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.28817798
40Nitrogen metabolism_Homo sapiens_hsa009101.27497039
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.26625423
42Biosynthesis of amino acids_Homo sapiens_hsa012301.25891354
43Fat digestion and absorption_Homo sapiens_hsa049751.25309045
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24812063
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24006206
46Pyruvate metabolism_Homo sapiens_hsa006201.19380512
47Glutathione metabolism_Homo sapiens_hsa004801.17595034
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.15933728
49beta-Alanine metabolism_Homo sapiens_hsa004101.15711260
50Starch and sucrose metabolism_Homo sapiens_hsa005001.10131126
51* Arachidonic acid metabolism_Homo sapiens_hsa005901.06962881
52Pentose phosphate pathway_Homo sapiens_hsa000301.06729316
53Histidine metabolism_Homo sapiens_hsa003401.06622311
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02419055
55Selenocompound metabolism_Homo sapiens_hsa004500.99128137
56Fatty acid metabolism_Homo sapiens_hsa012120.98846945
57Vitamin digestion and absorption_Homo sapiens_hsa049770.98246962
58Tyrosine metabolism_Homo sapiens_hsa003500.96465973
59Caffeine metabolism_Homo sapiens_hsa002320.95716225
60Oxidative phosphorylation_Homo sapiens_hsa001900.94407128
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86754729
62Phenylalanine metabolism_Homo sapiens_hsa003600.83832228
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82531153
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81938749
65Glycerolipid metabolism_Homo sapiens_hsa005610.80331123
66* Metabolic pathways_Homo sapiens_hsa011000.76481723
67Thyroid cancer_Homo sapiens_hsa052160.74114015
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73913179
69Ribosome_Homo sapiens_hsa030100.70722715
70Parkinsons disease_Homo sapiens_hsa050120.67714462
71Sphingolipid metabolism_Homo sapiens_hsa006000.67626687
72Vibrio cholerae infection_Homo sapiens_hsa051100.64342250
73Arginine and proline metabolism_Homo sapiens_hsa003300.62560157
74One carbon pool by folate_Homo sapiens_hsa006700.60442427
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.58742680
76Other glycan degradation_Homo sapiens_hsa005110.58722391
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.58626889
78DNA replication_Homo sapiens_hsa030300.58252882
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52615595
80Prion diseases_Homo sapiens_hsa050200.52231474
81ABC transporters_Homo sapiens_hsa020100.50725917
82N-Glycan biosynthesis_Homo sapiens_hsa005100.49934114
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49916687
84Renin-angiotensin system_Homo sapiens_hsa046140.49077252
85Pyrimidine metabolism_Homo sapiens_hsa002400.48271206
86Fatty acid elongation_Homo sapiens_hsa000620.48131552
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44680494
88Regulation of autophagy_Homo sapiens_hsa041400.42163261
89Alzheimers disease_Homo sapiens_hsa050100.37498316
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35869559
91Ether lipid metabolism_Homo sapiens_hsa005650.33897732
92Huntingtons disease_Homo sapiens_hsa050160.33523863
93Lysosome_Homo sapiens_hsa041420.33409613
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32762632
95Base excision repair_Homo sapiens_hsa034100.30853299
96Protein digestion and absorption_Homo sapiens_hsa049740.29713613
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27812848
98Mismatch repair_Homo sapiens_hsa034300.27750136
99Staphylococcus aureus infection_Homo sapiens_hsa051500.24725016
100Cardiac muscle contraction_Homo sapiens_hsa042600.24597023
101Ovarian steroidogenesis_Homo sapiens_hsa049130.24457144
102Mineral absorption_Homo sapiens_hsa049780.24205145
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.23793270
104mTOR signaling pathway_Homo sapiens_hsa041500.23660746
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23647388
106Steroid biosynthesis_Homo sapiens_hsa001000.22757561
107Lysine degradation_Homo sapiens_hsa003100.21095379
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20550226
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19986670
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19395532
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19117658
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14456091
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.14236916
114Synaptic vesicle cycle_Homo sapiens_hsa047210.14032534
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13961421
116Protein export_Homo sapiens_hsa030600.13293984
117AMPK signaling pathway_Homo sapiens_hsa041520.12381931
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11856832
119Pancreatic secretion_Homo sapiens_hsa049720.10965002
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08561753
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.08306490
122Purine metabolism_Homo sapiens_hsa002300.07547474
123Collecting duct acid secretion_Homo sapiens_hsa049660.04521400
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04328261

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »