CBR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.86328398
2maintenance of protein location in nucleus (GO:0051457)6.96118647
3regulation of response to osmotic stress (GO:0047484)6.73603414
4somite rostral/caudal axis specification (GO:0032525)6.65491488
5regulation of mammary gland epithelial cell proliferation (GO:0033599)6.59072472
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.29034718
7negative regulation of epidermis development (GO:0045683)6.25755450
8negative regulation of telomerase activity (GO:0051974)5.88989257
9protein localization to kinetochore (GO:0034501)5.87535500
10regulation of nuclear cell cycle DNA replication (GO:0033262)5.80199163
11muscle organ morphogenesis (GO:0048644)5.74323329
12regulation of MHC class I biosynthetic process (GO:0045343)5.64317791
13regulation of telomere maintenance via telomerase (GO:0032210)5.63433869
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.59693497
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.59377265
16histone H4-K12 acetylation (GO:0043983)5.47049651
17histone H4-K8 acetylation (GO:0043982)5.40685715
18histone H4-K5 acetylation (GO:0043981)5.40685715
19rRNA transcription (GO:0009303)5.22280219
20notochord development (GO:0030903)5.17728887
21cytidine deamination (GO:0009972)5.12693915
22cytidine metabolic process (GO:0046087)5.12693915
23cytidine catabolic process (GO:0006216)5.12693915
24hormone catabolic process (GO:0042447)4.92982241
25negative regulation of epidermal cell differentiation (GO:0045605)4.87300347
26regulation of cilium movement (GO:0003352)4.72684775
27phenol-containing compound catabolic process (GO:0019336)4.72524564
28barbed-end actin filament capping (GO:0051016)4.69805744
29response to dietary excess (GO:0002021)4.69201628
30mitotic sister chromatid segregation (GO:0000070)4.68597076
31regulation of apoptotic process involved in morphogenesis (GO:1902337)4.68578288
32heterochromatin organization (GO:0070828)4.60248871
33protein maturation by protein folding (GO:0022417)4.50547744
34rRNA methylation (GO:0031167)4.47451585
35nucleoside transmembrane transport (GO:1901642)4.46624929
36positive regulation of DNA-dependent DNA replication (GO:2000105)4.45486921
37branching involved in mammary gland duct morphogenesis (GO:0060444)4.45186423
38primitive streak formation (GO:0090009)4.31173490
39interferon-gamma production (GO:0032609)4.27413131
40protein localization to chromosome, centromeric region (GO:0071459)4.18745501
41negative regulation of telomere maintenance (GO:0032205)4.13573662
42regulation of translation in response to stress (GO:0043555)4.12905376
43rRNA modification (GO:0000154)4.08676397
44cell fate commitment involved in formation of primary germ layer (GO:0060795)4.04845879
45DNA replication-dependent nucleosome assembly (GO:0006335)4.04553926
46DNA replication-dependent nucleosome organization (GO:0034723)4.04553926
47chromatin assembly (GO:0031497)3.99008028
48cellular modified amino acid catabolic process (GO:0042219)3.97232430
49maintenance of protein localization in organelle (GO:0072595)3.97186749
50negative regulation of nitric oxide biosynthetic process (GO:0045019)3.93048597
51intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.89937273
52histone H4-K16 acetylation (GO:0043984)3.87163428
53pinocytosis (GO:0006907)3.83676224
54epoxygenase P450 pathway (GO:0019373)3.82645641
55sister chromatid segregation (GO:0000819)3.80991990
56intestinal epithelial cell development (GO:0060576)3.77493718
57extracellular fibril organization (GO:0043206)3.76222176
58arachidonic acid secretion (GO:0050482)3.73367272
59icosanoid secretion (GO:0032309)3.73367272
60bone trabecula formation (GO:0060346)3.73229214
61positive regulation of protein deacetylation (GO:0090312)3.72210812
62nuclear pore complex assembly (GO:0051292)3.71127937
63mitochondrion distribution (GO:0048311)3.69540153
64vitamin A metabolic process (GO:0006776)3.68074732
65cardiovascular system development (GO:0072358)3.67057901
66fibril organization (GO:0097435)3.64932909
67negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.62856368
68retinoic acid receptor signaling pathway (GO:0048384)3.62514674
69pyrimidine ribonucleoside catabolic process (GO:0046133)3.61903241
70virion attachment to host cell (GO:0019062)3.61475719
71adhesion of symbiont to host cell (GO:0044650)3.61475719
72DNA replication checkpoint (GO:0000076)3.58895322
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.58340568
74regulation of telomerase activity (GO:0051972)3.56374623
75protein localization to endosome (GO:0036010)3.55891120
76intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.55419757
77regulation of gene silencing by RNA (GO:0060966)3.54659355
78regulation of posttranscriptional gene silencing (GO:0060147)3.54659355
79regulation of gene silencing by miRNA (GO:0060964)3.54659355
80GDP-mannose metabolic process (GO:0019673)3.53254216
81melanin biosynthetic process (GO:0042438)3.45758758
82cullin deneddylation (GO:0010388)3.42470540
83phagocytosis, recognition (GO:0006910)3.42382536
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41313957
85nucleoside transport (GO:0015858)3.39875336
86trophectodermal cell differentiation (GO:0001829)3.39605567
87proline transport (GO:0015824)3.36918149
88maternal placenta development (GO:0001893)3.35405898
89transcription from mitochondrial promoter (GO:0006390)3.31253920
90pre-miRNA processing (GO:0031054)3.30434604
91microtubule severing (GO:0051013)3.29872727
92tachykinin receptor signaling pathway (GO:0007217)3.27874917
93regulation of telomere maintenance (GO:0032204)3.27874379
94positive regulation of histone deacetylation (GO:0031065)3.27401270
95type B pancreatic cell proliferation (GO:0044342)3.27141813
96RNA stabilization (GO:0043489)3.25124611
97mRNA stabilization (GO:0048255)3.25124611
98membrane raft organization (GO:0031579)3.25029568
99regulation of vitamin D biosynthetic process (GO:0060556)3.23102682
100nuclear pore organization (GO:0006999)3.22474262
101COPI coating of Golgi vesicle (GO:0048205)3.21945298
102Golgi transport vesicle coating (GO:0048200)3.21945298
103omega-hydroxylase P450 pathway (GO:0097267)3.21264351
104negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.18968754
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.18636070
106cellular response to zinc ion (GO:0071294)3.14272105
107adhesion of symbiont to host (GO:0044406)3.13721252
108L-ascorbic acid metabolic process (GO:0019852)3.13716700
109hypotonic response (GO:0006971)3.12143918
110pyrimidine-containing compound salvage (GO:0008655)3.10653377
111pyrimidine nucleoside salvage (GO:0043097)3.10653377
112transepithelial transport (GO:0070633)3.09899805
113cyclooxygenase pathway (GO:0019371)3.09811152
114nucleobase-containing small molecule interconversion (GO:0015949)3.09111990
115negative regulation of interleukin-2 production (GO:0032703)3.09021704
116primary alcohol catabolic process (GO:0034310)3.07039371
117regulation of hippo signaling (GO:0035330)3.06811480
118positive regulation of macrophage cytokine production (GO:0060907)3.06755342
119ribosome biogenesis (GO:0042254)3.05860263
120mature B cell differentiation involved in immune response (GO:0002313)3.05263998
121skin morphogenesis (GO:0043589)3.05132634
122positive regulation of endothelial cell apoptotic process (GO:2000353)3.03731458
123negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.02376048
124deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95766684
125melanin metabolic process (GO:0006582)2.95487288
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95453116
127regulation of vitamin metabolic process (GO:0030656)2.92619238
128proteasome assembly (GO:0043248)2.87023692
129hyaluronan catabolic process (GO:0030214)2.86614863
130regulation of integrin-mediated signaling pathway (GO:2001044)2.83247432
131cellular response to arsenic-containing substance (GO:0071243)2.78720169
132natural killer cell mediated immunity (GO:0002228)2.77653046
133natural killer cell mediated cytotoxicity (GO:0042267)2.77653046
134negative regulation of response to reactive oxygen species (GO:1901032)2.77539250
135cellular response to interferon-alpha (GO:0035457)2.73410716
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.73359879
137negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.68603852
138UV protection (GO:0009650)2.68083254
139pentose-phosphate shunt (GO:0006098)2.67788195
140GTP biosynthetic process (GO:0006183)2.65381406
141nuclear envelope reassembly (GO:0031468)2.62085807
142mitotic nuclear envelope reassembly (GO:0007084)2.62085807
143regulation of hydrogen peroxide-induced cell death (GO:1903205)2.61852553
144negative regulation of smooth muscle cell migration (GO:0014912)2.61294039
145nucleoside salvage (GO:0043174)2.59600078
146NIK/NF-kappaB signaling (GO:0038061)2.58151066
147positive regulation of Cdc42 GTPase activity (GO:0043089)2.57485884
148response to progesterone (GO:0032570)2.56061312
149protein retention in ER lumen (GO:0006621)2.53992215
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53369102
151regulation of T-helper 1 cell differentiation (GO:0045625)2.52961350
152amino sugar catabolic process (GO:0046348)2.50842279
153low-density lipoprotein particle clearance (GO:0034383)2.48092959
154response to type I interferon (GO:0034340)2.48091972
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47700678
156guanosine-containing compound biosynthetic process (GO:1901070)2.47560312
157UTP biosynthetic process (GO:0006228)2.46854713
158regulation of necrotic cell death (GO:0010939)2.44953473
159response to thyroid hormone (GO:0097066)2.41699735
160cell adhesion mediated by integrin (GO:0033627)2.39206974
161secondary metabolite biosynthetic process (GO:0044550)2.38950750
162cellular response to type I interferon (GO:0071357)2.38438143
163type I interferon signaling pathway (GO:0060337)2.38438143
164AMP metabolic process (GO:0046033)2.38172465
165positive regulation of keratinocyte differentiation (GO:0045618)2.38002459
166glucose catabolic process (GO:0006007)2.37809457
167cellular response to thyroid hormone stimulus (GO:0097067)2.37689171
168response to copper ion (GO:0046688)2.36910017
169negative regulation of JAK-STAT cascade (GO:0046426)2.36800828
170endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.36516004
171muscle cell migration (GO:0014812)2.35915436
172desmosome organization (GO:0002934)2.35447254
173purine nucleotide salvage (GO:0032261)2.35205855
174positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.34995871
175maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.33592875
176regulation of early endosome to late endosome transport (GO:2000641)2.32442853
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.32006716
178regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31093548
179stress fiber assembly (GO:0043149)2.30805325
180cellular response to cadmium ion (GO:0071276)2.28917682
181cellular copper ion homeostasis (GO:0006878)2.28734498
182nucleotide salvage (GO:0043173)2.27952986
183positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26379249
184negative regulation of smooth muscle cell proliferation (GO:0048662)2.26162426
185keratan sulfate catabolic process (GO:0042340)2.26161080
186regulation of chronic inflammatory response (GO:0002676)2.25136444
187regulation of immunoglobulin secretion (GO:0051023)2.24871562
188negative regulation of monooxygenase activity (GO:0032769)2.24048837
189lipoxygenase pathway (GO:0019372)2.20891901
190positive regulation of chemokine biosynthetic process (GO:0045080)2.20492198
191NADPH regeneration (GO:0006740)2.19860519
192doxorubicin metabolic process (GO:0044598)12.1861294
193daunorubicin metabolic process (GO:0044597)12.1861294
194polyketide metabolic process (GO:0030638)12.1861294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.84423129
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.84423129
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.84423129
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.69747601
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.41225786
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.92538667
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.46316834
8* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.27911783
9E2F7_22180533_ChIP-Seq_HELA_Human3.27278775
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.12920724
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.04396252
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.97629189
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.92708294
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.79163113
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79079828
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.77621501
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.68878190
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.63998784
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35777898
20ZNF263_19887448_ChIP-Seq_K562_Human2.18263126
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14609080
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10571320
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09933603
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.07297689
25NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.06956438
26* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06491385
27* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.01167392
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01054001
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98119307
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95001797
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94459712
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92555501
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92086682
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91652253
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84919402
36* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84671057
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84619316
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83631266
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82691366
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81297220
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79686451
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.75474080
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73213947
44VDR_21846776_ChIP-Seq_THP-1_Human1.73133048
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.68044425
46TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.66944017
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.65744951
48IRF1_19129219_ChIP-ChIP_H3396_Human1.62594886
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62197101
50NANOG_18692474_ChIP-Seq_MEFs_Mouse1.61284512
51NANOG_18692474_ChIP-Seq_MESCs_Mouse1.56473052
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56114731
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53896793
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52627387
55* ATF3_27146783_Chip-Seq_COLON_Human1.51915021
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51817843
57CLOCK_20551151_ChIP-Seq_293T_Human1.49646063
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.46008667
59AR_21909140_ChIP-Seq_LNCAP_Human1.45169062
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45044383
61PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.44237586
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.44117287
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43733377
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43073825
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43011322
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43011322
67OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40867483
68* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.40020426
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39874801
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36071702
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35588153
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.35430734
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34170441
74TFEB_21752829_ChIP-Seq_HELA_Human1.32089951
75SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31972528
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31499242
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30020766
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29889449
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29826831
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.29823705
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29027617
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28855412
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28003412
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27031168
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25774815
86NANOG_16518401_ChIP-PET_MESCs_Mouse1.25735214
87DCP1A_22483619_ChIP-Seq_HELA_Human1.24231928
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.22279974
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21561533
90* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.21387503
91VDR_24763502_ChIP-Seq_THP-1_Human1.20918958
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19302282
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19191504
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19057365
95* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17600735
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.16494305
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.16360374
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16149733
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.13495235
100IRF8_21731497_ChIP-ChIP_J774_Mouse1.13395457
101MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13037391
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11998126
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11691486
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11308787
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09947497
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09621566
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09522013
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09295617
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.09128162
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08649083
111TP53_22127205_ChIP-Seq_IMR90_Human1.08011226
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07782475
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07574054
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06882865
115* ELF1_20517297_ChIP-Seq_JURKAT_Human1.05506272
116* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04723815
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03689893
118MYC_22102868_ChIP-Seq_BL_Human1.03463035
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.03316445
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02434009
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01907096
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.01887804
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00939011
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.00719635
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00652615
126NCOR1_26117541_ChIP-Seq_K562_Human0.98591907
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.97932901
128* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96351380
129SOX2_20726797_ChIP-Seq_SW620_Human0.96106378
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96015385
131ELF5_23300383_ChIP-Seq_T47D_Human0.95573201
132GABP_19822575_ChIP-Seq_HepG2_Human0.95238902
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95137249
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95060699
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94917797
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93743824
137* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91358567
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.89953110
139* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88891349
140* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87444812
141RACK7_27058665_Chip-Seq_MCF-7_Human0.85900818
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84308407
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83893928
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83042930
145KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83001399
146TCF7_22412390_ChIP-Seq_EML_Mouse0.82910252
147KAP1_27257070_Chip-Seq_ESCs_Mouse0.81837981
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79516570
149* ELK3_25401928_ChIP-Seq_HUVEC_Human0.79467302
150SMC4_20622854_ChIP-Seq_HELA_Human0.78954265
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78723267
152WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76965323
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.76091470
154STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75272428
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.75167549
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74074987
157TP53_20018659_ChIP-ChIP_R1E_Mouse0.73814190
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73723777
159LXR_22292898_ChIP-Seq_THP-1_Human0.73168975
160KDM2B_26808549_Chip-Seq_K562_Human0.72987912
161* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72832897
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72697752
163RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71468254
164EGR1_19374776_ChIP-ChIP_THP-1_Human0.71394657
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71150612
166CTCF_21964334_Chip-Seq_Bcells_Human0.70230904
167* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68081343
168* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.67650443
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67432092
170* FOXO3_23340844_ChIP-Seq_DLD1_Human0.67308489
171* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.66256823
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66106277
173E2F1_18555785_ChIP-Seq_MESCs_Mouse0.65683540
174KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65501801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.86961743
2MP0003011_delayed_dark_adaptation4.78915405
3MP0003806_abnormal_nucleotide_metabolis4.48644534
4MP0004264_abnormal_extraembryonic_tissu4.37074638
5MP0006292_abnormal_olfactory_placode4.13614332
6MP0004858_abnormal_nervous_system3.57179699
7MP0005058_abnormal_lysosome_morphology3.49546473
8MP0003890_abnormal_embryonic-extraembry3.49089105
9MP0008438_abnormal_cutaneous_collagen3.42836939
10MP0005499_abnormal_olfactory_system3.20166967
11MP0005394_taste/olfaction_phenotype3.20166967
12MP0003705_abnormal_hypodermis_morpholog3.12208119
13MP0002332_abnormal_exercise_endurance3.02584196
14MP0005075_abnormal_melanosome_morpholog3.01509462
15MP0005257_abnormal_intraocular_pressure2.82434028
16MP0003122_maternal_imprinting2.52608798
17MP0004957_abnormal_blastocyst_morpholog2.46102880
18MP0008057_abnormal_DNA_replication2.44911780
19MP0003191_abnormal_cellular_cholesterol2.44638121
20MP0010352_gastrointestinal_tract_polyps2.44496693
21MP0009840_abnormal_foam_cell2.37284041
22MP0004510_myositis2.34540176
23MP0003279_aneurysm2.33175548
24MP0002653_abnormal_ependyma_morphology2.31998913
25MP0000678_abnormal_parathyroid_gland2.29565082
26MP0006035_abnormal_mitochondrial_morpho2.18306711
27MP0002148_abnormal_hypersensitivity_rea2.11487961
28MP0010234_abnormal_vibrissa_follicle2.05777078
29MP0003950_abnormal_plasma_membrane2.03155135
30MP0006054_spinal_hemorrhage2.02850136
31MP0005171_absent_coat_pigmentation1.99083146
32MP0010030_abnormal_orbit_morphology1.98423908
33MP0003453_abnormal_keratinocyte_physiol1.91267714
34MP0001542_abnormal_bone_strength1.88000738
35MP0003121_genomic_imprinting1.84238745
36MP0003303_peritoneal_inflammation1.83454372
37MP0005275_abnormal_skin_tensile1.82890900
38MP0008961_abnormal_basal_metabolism1.82762723
39MP0003075_altered_response_to1.80327974
40MP0003938_abnormal_ear_development1.74752769
41MP0005380_embryogenesis_phenotype1.73340554
42MP0001672_abnormal_embryogenesis/_devel1.73340554
43MP0002277_abnormal_respiratory_mucosa1.69768356
44MP0001849_ear_inflammation1.65943682
45MP0002088_abnormal_embryonic_growth/wei1.61219253
46MP0001293_anophthalmia1.60964583
47MP0006082_CNS_inflammation1.60461817
48MP0001958_emphysema1.60425952
49MP0002127_abnormal_cardiovascular_syste1.59749998
50MP0005165_increased_susceptibility_to1.59067945
51MP0003984_embryonic_growth_retardation1.58908757
52MP0003183_abnormal_peptide_metabolism1.56924241
53MP0001853_heart_inflammation1.55546260
54MP0000762_abnormal_tongue_morphology1.52108651
55MP0000049_abnormal_middle_ear1.49000598
56MP0002092_abnormal_eye_morphology1.44041485
57MP0002932_abnormal_joint_morphology1.44040685
58MP0003436_decreased_susceptibility_to1.42920043
59MP0000015_abnormal_ear_pigmentation1.42881044
60MP0002060_abnormal_skin_morphology1.42282711
61MP0005408_hypopigmentation1.39489669
62MP0005266_abnormal_metabolism1.32061966
63MP0000350_abnormal_cell_proliferation1.31154253
64MP0005501_abnormal_skin_physiology1.29612907
65MP0000372_irregular_coat_pigmentation1.28218384
66MP0004133_heterotaxia1.26597365
67MP0001533_abnormal_skeleton_physiology1.25810145
68MP0009333_abnormal_splenocyte_physiolog1.25319139
69MP0004947_skin_inflammation1.24531224
70MP0002086_abnormal_extraembryonic_tissu1.24492141
71MP0003300_gastrointestinal_ulcer1.24009419
72MP0002233_abnormal_nose_morphology1.22967623
73MP0008789_abnormal_olfactory_epithelium1.22834312
74MP0003091_abnormal_cell_migration1.22647502
75MP0005248_abnormal_Harderian_gland1.20814216
76MP0005451_abnormal_body_composition1.20678661
77MP0005166_decreased_susceptibility_to1.20279341
78MP0002085_abnormal_embryonic_tissue1.17458420
79MP0005508_abnormal_skeleton_morphology1.17123997
80MP0001835_abnormal_antigen_presentation1.16095884
81MP0008004_abnormal_stomach_pH1.15551510
82MP0001348_abnormal_lacrimal_gland1.15099119
83MP0009785_altered_susceptibility_to1.14975616
84MP0000371_diluted_coat_color1.12603206
85MP0010368_abnormal_lymphatic_system1.12480910
86MP0001216_abnormal_epidermal_layer1.12253023
87MP0003283_abnormal_digestive_organ1.11954289
88MP0000432_abnormal_head_morphology1.11854827
89MP0008260_abnormal_autophagy1.11187427
90MP0003755_abnormal_palate_morphology1.08534238
91MP0002970_abnormal_white_adipose1.07718509
92MP0009278_abnormal_bone_marrow1.07411393
93MP0000428_abnormal_craniofacial_morphol1.06414494
94MP0002114_abnormal_axial_skeleton1.05989776
95MP0005023_abnormal_wound_healing1.05283667
96MP0003724_increased_susceptibility_to1.03447718
97MP0000767_abnormal_smooth_muscle1.03441673
98MP0005670_abnormal_white_adipose1.02675964
99MP0002084_abnormal_developmental_patter1.02050564
100MP0004233_abnormal_muscle_weight1.01434334
101MP0002998_abnormal_bone_remodeling1.00552398
102MP0003119_abnormal_digestive_system0.99254043
103MP0003935_abnormal_craniofacial_develop0.99253818
104MP0005503_abnormal_tendon_morphology0.99055993
105MP0001545_abnormal_hematopoietic_system0.99047159
106MP0005397_hematopoietic_system_phenotyp0.99047159
107MP0003123_paternal_imprinting0.99033584
108MP0000750_abnormal_muscle_regeneration0.98880290
109MP0004043_abnormal_pH_regulation0.96419295
110MP0005390_skeleton_phenotype0.96227937
111MP0003077_abnormal_cell_cycle0.95981378
112MP0004197_abnormal_fetal_growth/weight/0.94929139
113MP0008007_abnormal_cellular_replicative0.93526380
114MP0008469_abnormal_protein_level0.92090622
115MP0002249_abnormal_larynx_morphology0.91619524
116MP0005666_abnormal_adipose_tissue0.91126379
117MP0004381_abnormal_hair_follicle0.90571575
118MP0005623_abnormal_meninges_morphology0.89211883
119MP0004185_abnormal_adipocyte_glucose0.87848603
120MP0002166_altered_tumor_susceptibility0.87106973
121MP0005330_cardiomyopathy0.87035363
122MP0002419_abnormal_innate_immunity0.86361694
123MP0002132_abnormal_respiratory_system0.86145833
124MP0000733_abnormal_muscle_development0.86145768
125MP0005025_abnormal_response_to0.86089650
126MP0005000_abnormal_immune_tolerance0.85737295
127MP0008770_decreased_survivor_rate0.85260857
128MP0002925_abnormal_cardiovascular_devel0.85100987
129MP0000490_abnormal_crypts_of0.85048325
130MP0003137_abnormal_impulse_conducting0.84524878
131MP0002095_abnormal_skin_pigmentation0.84493624
132MP0002295_abnormal_pulmonary_circulatio0.84466524
133MP0004808_abnormal_hematopoietic_stem0.83695800
134MP0002396_abnormal_hematopoietic_system0.83364242
135MP0005391_vision/eye_phenotype0.82903003
136MP0005164_abnormal_response_to0.81280956
137MP0001845_abnormal_inflammatory_respons0.79126170
138MP0006036_abnormal_mitochondrial_physio0.78692099
139MP0000313_abnormal_cell_death0.78160993
140MP0002796_impaired_skin_barrier0.77959958
141MP0000749_muscle_degeneration0.77236874
142MP0002116_abnormal_craniofacial_bone0.76897319
143MP0003763_abnormal_thymus_physiology0.74718903
144MP0005375_adipose_tissue_phenotype0.74271491
145MP0002098_abnormal_vibrissa_morphology0.74135900
146MP0000627_abnormal_mammary_gland0.73942327
147MP0001881_abnormal_mammary_gland0.73324761
148MP0000604_amyloidosis0.72890357
149MP0005621_abnormal_cell_physiology0.72450011
150MP0000343_altered_response_to0.72187981
151MP0005595_abnormal_vascular_smooth0.71425177
152MP0005319_abnormal_enzyme/_coenzyme0.71172057
153MP0002452_abnormal_antigen_presenting0.70535085
154MP0004272_abnormal_basement_membrane0.70364820
155MP0010771_integument_phenotype0.69802144
156MP0001730_embryonic_growth_arrest0.69655190
157MP0001697_abnormal_embryo_size0.68196843
158MP0002080_prenatal_lethality0.68183198
159MP0002269_muscular_atrophy0.67534586
160MP0003315_abnormal_perineum_morphology0.67489227
161MP0001286_abnormal_eye_development0.66992792
162MP0003448_altered_tumor_morphology0.66858154
163MP0005197_abnormal_uvea_morphology0.66416750
164MP0003937_abnormal_limbs/digits/tail_de0.65992329
165MP0002751_abnormal_autonomic_nervous0.65787377
166MP0003566_abnormal_cell_adhesion0.65001686
167MP0003111_abnormal_nucleus_morphology0.63494102
168MP0002877_abnormal_melanocyte_morpholog0.62946714
169MP0008932_abnormal_embryonic_tissue0.62922261
170MP0000358_abnormal_cell_content/0.62873418
171MP0003186_abnormal_redox_activity0.62456583
172MP0001243_abnormal_dermal_layer0.61248890
173MP0009703_decreased_birth_body0.60946744
174MP0004883_abnormal_blood_vessel0.60288000
175MP0009115_abnormal_fat_cell0.60134810
176MP0000858_altered_metastatic_potential0.58128214

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.55243957
2Hypochromic microcytic anemia (HP:0004840)6.04543069
3Hepatoblastoma (HP:0002884)5.44430512
4Multiple enchondromatosis (HP:0005701)5.28150626
5Abnormality of the lower motor neuron (HP:0002366)4.99600301
6Rib fusion (HP:0000902)4.88321725
7Premature rupture of membranes (HP:0001788)4.59318358
8Vertebral compression fractures (HP:0002953)4.32323081
9Ependymoma (HP:0002888)4.17804126
10Neoplasm of striated muscle (HP:0009728)3.73055783
11Reduced subcutaneous adipose tissue (HP:0003758)3.60403347
12Axonal loss (HP:0003447)3.57070993
13Fused cervical vertebrae (HP:0002949)3.52881500
14Rhabdomyosarcoma (HP:0002859)3.52464713
15Partial duplication of thumb phalanx (HP:0009944)3.51094835
16Nephroblastoma (Wilms tumor) (HP:0002667)3.49893693
17Testicular atrophy (HP:0000029)3.49621736
18Protrusio acetabuli (HP:0003179)3.49612270
19Rectal fistula (HP:0100590)3.46561782
20Rectovaginal fistula (HP:0000143)3.46561782
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.45204458
22Hypoplasia of the fovea (HP:0007750)3.45204458
23Dysostosis multiplex (HP:0000943)3.42451514
24Nuclear cataract (HP:0100018)3.32919788
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31048684
26Embryonal renal neoplasm (HP:0011794)3.28836276
27Osteolytic defects of the hand bones (HP:0009699)3.28231834
28Osteolytic defects of the phalanges of the hand (HP:0009771)3.28231834
29Prolonged neonatal jaundice (HP:0006579)3.16354899
30Vaginal fistula (HP:0004320)3.15531224
31Hyperinsulinemic hypoglycemia (HP:0000825)3.15144900
32Partial duplication of the phalanx of hand (HP:0009999)3.11663054
33Abnormality of the salivary glands (HP:0010286)3.10308958
34Loss of speech (HP:0002371)3.08636276
35Intestinal fistula (HP:0100819)3.06395741
36Trismus (HP:0000211)3.05308409
37Follicular hyperkeratosis (HP:0007502)3.00732627
38Bifid tongue (HP:0010297)2.96820003
39Aplasia/hypoplasia of the humerus (HP:0006507)2.96573376
40Astrocytoma (HP:0009592)2.96525448
41Abnormality of the astrocytes (HP:0100707)2.96525448
42Short humerus (HP:0005792)2.95679344
43Abnormal cartilage morphology (HP:0002763)2.93363859
44Anomalous pulmonary venous return (HP:0010772)2.87133310
45Ragged-red muscle fibers (HP:0003200)2.85265948
46Amyotrophic lateral sclerosis (HP:0007354)2.83086740
47Spinal rigidity (HP:0003306)2.83086132
48Horizontal nystagmus (HP:0000666)2.78912767
49Chromsome breakage (HP:0040012)2.75517956
50Cervical subluxation (HP:0003308)2.72697851
51Abnormality of the distal phalanges of the toes (HP:0010182)2.71435524
52Short nail (HP:0001799)2.70785632
53Abnormal lung lobation (HP:0002101)2.70156195
54Ankle contracture (HP:0006466)2.64011905
55Vacuolated lymphocytes (HP:0001922)2.60757783
56Elbow flexion contracture (HP:0002987)2.60017113
57Reduced antithrombin III activity (HP:0001976)2.59123812
58Large earlobe (HP:0009748)2.58121098
59Abnormality of the fovea (HP:0000493)2.57026594
60Preauricular skin tag (HP:0000384)2.54903256
61Abnormality of the phalanges of the hallux (HP:0010057)2.54565264
62Increased connective tissue (HP:0009025)2.54544819
63Patchy hypopigmentation of hair (HP:0011365)2.54510411
64White forelock (HP:0002211)2.54336101
65Hypochromic anemia (HP:0001931)2.52247091
66Shawl scrotum (HP:0000049)2.50868419
67Generalized amyotrophy (HP:0003700)2.49749496
68Abnormality of the pulmonary veins (HP:0011718)2.46249849
69Generalized hypotonia (HP:0001290)2.44559019
70Preauricular pit (HP:0004467)2.44418590
71Periauricular skin pits (HP:0100277)2.44418590
72Abnormality of the Achilles tendon (HP:0005109)2.41677628
73Spondylolisthesis (HP:0003302)2.38671067
74Neoplasm of head and neck (HP:0012288)2.35311280
75Esophageal neoplasm (HP:0100751)2.35311280
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34781229
77Nasolacrimal duct obstruction (HP:0000579)2.34291768
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.33499458
79Progressive muscle weakness (HP:0003323)2.32924747
80Distal lower limb muscle weakness (HP:0009053)2.32102984
81Abnormality of liposaccharide metabolism (HP:0010968)2.31402810
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.31402810
83Abnormality of glycolipid metabolism (HP:0010969)2.31402810
84Sensory axonal neuropathy (HP:0003390)2.31061009
85Hand muscle atrophy (HP:0009130)2.30241562
86Abnormality of the musculature of the hand (HP:0001421)2.30212173
87Systemic lupus erythematosus (HP:0002725)2.29982652
88Supernumerary spleens (HP:0009799)2.26791707
89Abnormality of polysaccharide metabolism (HP:0011012)2.26442358
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26442358
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26442358
92Neoplasm of the heart (HP:0100544)2.25894958
93Skin tags (HP:0010609)2.23164751
94Congenital ichthyosiform erythroderma (HP:0007431)2.23017707
95Difficulty running (HP:0009046)2.22571678
96Hyperventilation (HP:0002883)2.22365536
97Tetraplegia (HP:0002445)2.22262248
98Tongue fasciculations (HP:0001308)2.22242924
99Aplasia/Hypoplasia of the macula (HP:0008059)2.21518859
100Impulsivity (HP:0100710)2.20119262
101Upper motor neuron abnormality (HP:0002127)2.19896528
102Abnormality of chromosome segregation (HP:0002916)2.19428267
103Mucopolysacchariduria (HP:0008155)2.19019782
104Urinary glycosaminoglycan excretion (HP:0003541)2.19019782
105Hepatosplenomegaly (HP:0001433)2.17653347
106Short 5th finger (HP:0009237)2.17569100
107Alopecia of scalp (HP:0002293)2.17389278
108Villous atrophy (HP:0011473)2.15232216
109Abnormality of small intestinal villus morphology (HP:0011472)2.15232216
110Increased cerebral lipofuscin (HP:0011813)2.15130929
111Glioma (HP:0009733)2.14454598
112Pseudobulbar signs (HP:0002200)2.13752085
113Multiple lipomas (HP:0001012)2.11939635
114Achilles tendon contracture (HP:0001771)2.11607924
115Cheilitis (HP:0100825)2.11607384
116Meckel diverticulum (HP:0002245)2.08711176
117Erythema (HP:0010783)2.08399013
118Rough bone trabeculation (HP:0100670)2.08298975
119Mildly elevated creatine phosphokinase (HP:0008180)2.07672210
120Abnormality of the pubic bones (HP:0003172)2.06383257
121Joint stiffness (HP:0001387)2.05852922
122Progressive neurologic deterioration (HP:0002344)2.05823017
123Acanthosis nigricans (HP:0000956)2.05398307
124Hypopigmentation of the fundus (HP:0007894)2.02637965
125Muscle fibrillation (HP:0010546)2.02317057
126Malignant neoplasm of the central nervous system (HP:0100836)2.01988971
127Hypoplastic scapulae (HP:0000882)2.01636715
128Aplasia/Hypoplasia of the scapulae (HP:0006713)2.01636715
129Natal tooth (HP:0000695)2.01209589
130Glucose intolerance (HP:0000833)2.01207035
131Glossoptosis (HP:0000162)2.01053263
132Malnutrition (HP:0004395)1.99537406
133Supernumerary nipples (HP:0002558)1.99312668
134Wormian bones (HP:0002645)1.98771712
135Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98639975
136Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98459077
137Abnormality of the nasal mucosa (HP:0000433)1.98321010
138Vertebral fusion (HP:0002948)1.98209270
139Interstitial pulmonary disease (HP:0006530)1.97878452
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.96852242
141Abnormality of the umbilical cord (HP:0010881)1.96811978
142Upper limb muscle weakness (HP:0003484)1.96520537
143Fasciculations (HP:0002380)1.96012773
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.95586475
145Abnormality of the ileum (HP:0001549)1.94928292
146Peritonitis (HP:0002586)1.94885335
147Bone cyst (HP:0012062)1.93786371
148Abnormality of the intrinsic pathway (HP:0010989)1.93679047
149Fragile skin (HP:0001030)1.92768965
150Skin pits (HP:0100276)1.92062595
151Renal duplication (HP:0000075)1.91180994
152Multifactorial inheritance (HP:0001426)1.91136479
153Hyperparathyroidism (HP:0000843)1.89722022
154Atrophic scars (HP:0001075)1.88732408
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.88649745
156Upper limb amyotrophy (HP:0009129)1.87488802
157Distal upper limb amyotrophy (HP:0007149)1.87488802
158Genu recurvatum (HP:0002816)1.84530661
159Bulbar palsy (HP:0001283)1.84043756
160Renal Fanconi syndrome (HP:0001994)1.83683229
161J-shaped sella turcica (HP:0002680)1.83342658
162Blue sclerae (HP:0000592)1.82923444
163Aortic aneurysm (HP:0004942)1.82072760
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81715276
165Cardiovascular calcification (HP:0011915)1.79671566
166Biconcave vertebral bodies (HP:0004586)1.79598604
167Sparse eyelashes (HP:0000653)1.79168382
168Ocular albinism (HP:0001107)1.78447550
169Spinal cord compression (HP:0002176)1.78258489
170Myocardial infarction (HP:0001658)1.77994083
171Conjunctival hamartoma (HP:0100780)1.77391147
172Aortic regurgitation (HP:0001659)1.76233146
173Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74026885
174Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72689392
175Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72215103
176Entropion (HP:0000621)1.71181805
177Cerebral inclusion bodies (HP:0100314)1.69932113
178Amyloidosis (HP:0011034)1.69152526
179Increased IgM level (HP:0003496)1.68201030
180Abnormal trabecular bone morphology (HP:0100671)1.68192361
181Abnormality of the frontal sinuses (HP:0002687)1.66911984
182Long toe (HP:0010511)1.66506398
183Microretrognathia (HP:0000308)1.65662053
184Polygenic inheritance (HP:0010982)1.62940644
185Tetraparesis (HP:0002273)1.62253616
186Broad face (HP:0000283)1.62173686
187Hypertriglyceridemia (HP:0002155)1.61190973
188Neurofibrillary tangles (HP:0002185)1.60340011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.09007635
2NME25.66842316
3GRK55.52957266
4ERN14.96352872
5GRK64.38932262
6TESK13.61097703
7IRAK33.46955422
8ADRBK23.32035633
9GRK13.27093435
10TGFBR22.87736284
11CSF1R2.79738536
12TYRO32.71631154
13MAP3K32.69099717
14ARAF2.67085742
15PIM22.59872325
16GRK72.56354055
17TTK2.42116466
18MATK2.41552570
19MAPK72.34554819
20MOS2.32042792
21STK102.25605384
22MYLK2.13974021
23LIMK12.13235085
24VRK22.05791015
25TBK11.96299389
26ABL21.92416743
27WNK11.88018088
28NTRK11.62809113
29MAP3K131.62637589
30EPHA21.61388661
31PRKG21.58807332
32MST1R1.54699525
33BUB11.53931820
34CDK71.48276925
35SMG11.45257468
36CAMK41.43721141
37MAP2K31.38024714
38ILK1.37919686
39SCYL21.37371619
40PAK41.36633955
41MARK31.35199704
42PBK1.30560011
43MARK21.26796794
44ADRBK11.19262135
45HIPK21.16265925
46MAP3K141.15325992
47CHEK21.08106238
48AKT31.06833906
49DAPK31.03136647
50FGFR31.03021171
51MAP3K100.97104932
52MAP2K40.93941767
53LATS20.93029531
54BRAF0.91535589
55PLK10.90825517
56MAP3K110.89570504
57TTN0.88861335
58STK160.85618759
59CSK0.85529137
60CSNK1G30.82917433
61BCKDK0.81945687
62ALK0.80845110
63CSNK1A1L0.79739466
64MAP3K120.79334333
65TRPM70.77025697
66PDK20.76692508
67DAPK10.73099952
68MAP3K10.72612696
69MAP2K60.72025206
70JAK30.71859780
71TYK20.70552707
72AKT20.70143156
73EIF2AK10.67495229
74PRKD30.67094210
75CDC42BPA0.66942482
76MAP3K90.66701980
77LMTK20.63702844
78KDR0.63495224
79MAP3K70.63411700
80MAPK120.61978487
81PDGFRA0.61097215
82IRAK20.60578329
83CHEK10.60388358
84EIF2AK20.57976341
85IKBKE0.54438750
86DDR20.54166076
87PTK20.52063947
88PRKCI0.48779426
89RIPK10.48500114
90MTOR0.48351817
91BMX0.48148510
92MAP3K80.47924837
93MAP3K60.47031146
94NEK90.46979745
95BRSK10.46672999
96CAMKK20.45817676
97IGF1R0.42977948
98RPS6KA20.41629919
99MAPKAPK30.40969492
100RPS6KB20.40882695
101CAMK2G0.40246691
102KIT0.39786392
103CCNB10.39223961
104PINK10.38853924
105WEE10.38264540
106IKBKB0.38257228
107MELK0.38151581
108MAPKAPK50.36491357
109TLK10.35777758
110CSNK1G20.35736525
111CDK20.35548417
112PRKCD0.34728410
113AURKA0.34687462
114PAK10.34044699
115BMPR20.33432845
116ERBB20.33393015
117CDK80.33361467
118MAPK110.32388057
119EEF2K0.32241166
120PRKD20.30116852
121TESK20.27952661
122INSR0.27630450
123MST40.27085745
124PRPF4B0.26612107
125NEK20.26607334
126MAPK100.24624239
127CSNK1E0.23564025
128ITK0.23499202
129STK380.23384382
130CDK40.20664771
131AURKB0.20529472
132GSK3A0.20186166
133DYRK20.19554476
134TAOK20.19502725
135PAK30.19414192
136MAPK10.19213896
137ATM0.18572987
138PRKACG0.17259313
139DYRK1B0.15931736
140TAOK10.15747078
141GSK3B0.15349909
142MAPK40.15304716
143CDK150.15193054
144CDC70.14660117
145CDK10.14327763
146MET0.13994048
147BLK0.13933711
148CHUK0.12900436
149MAPK140.12766047
150CDK11A0.12743602
151SIK10.12156658
152CDK180.11630344
153TRIB30.11382447
154NEK10.11234326
155PAK60.11164578
156PRKACB0.09806578
157PRKACA0.09359593
158MAPKAPK20.09276954
159PAK20.08765288
160PRKAA10.08396480
161ERBB40.08080475
162ICK0.07813947

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.88573466
2Vitamin B6 metabolism_Homo sapiens_hsa007506.54001318
3Fructose and mannose metabolism_Homo sapiens_hsa000514.23455626
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82201440
5Proteasome_Homo sapiens_hsa030502.98155225
6Galactose metabolism_Homo sapiens_hsa000522.94032805
7Lysosome_Homo sapiens_hsa041422.79146536
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.59435867
9Linoleic acid metabolism_Homo sapiens_hsa005912.24673212
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21167540
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14768926
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10294208
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.90335282
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88759267
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80751953
16* Arachidonic acid metabolism_Homo sapiens_hsa005901.80353033
17Thyroid cancer_Homo sapiens_hsa052161.74751131
18TNF signaling pathway_Homo sapiens_hsa046681.73754547
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.71936830
20* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66651414
21mTOR signaling pathway_Homo sapiens_hsa041501.63334487
22Shigellosis_Homo sapiens_hsa051311.45583000
23Chemical carcinogenesis_Homo sapiens_hsa052041.45567296
24Rheumatoid arthritis_Homo sapiens_hsa053231.45460574
25Sulfur metabolism_Homo sapiens_hsa009201.44694231
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43607095
27Other glycan degradation_Homo sapiens_hsa005111.43470927
28Vibrio cholerae infection_Homo sapiens_hsa051101.42571433
29Pyrimidine metabolism_Homo sapiens_hsa002401.40650236
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.38477045
31Malaria_Homo sapiens_hsa051441.37994904
32Tyrosine metabolism_Homo sapiens_hsa003501.33911141
33RNA transport_Homo sapiens_hsa030131.30731647
34N-Glycan biosynthesis_Homo sapiens_hsa005101.30488608
35Pertussis_Homo sapiens_hsa051331.28474235
36Salmonella infection_Homo sapiens_hsa051321.26266838
37Sphingolipid metabolism_Homo sapiens_hsa006001.20243310
38Osteoclast differentiation_Homo sapiens_hsa043801.14345309
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.12041378
40Fatty acid elongation_Homo sapiens_hsa000621.11114853
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.10525372
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10052270
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09978621
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08585926
45Asthma_Homo sapiens_hsa053101.07297851
46Nucleotide excision repair_Homo sapiens_hsa034201.07257929
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04167615
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03479097
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02325700
50One carbon pool by folate_Homo sapiens_hsa006701.00637187
51Ovarian steroidogenesis_Homo sapiens_hsa049131.00533198
52Basal cell carcinoma_Homo sapiens_hsa052171.00088968
53Allograft rejection_Homo sapiens_hsa053300.98473553
54mRNA surveillance pathway_Homo sapiens_hsa030150.97645961
55Ether lipid metabolism_Homo sapiens_hsa005650.97034575
56Prion diseases_Homo sapiens_hsa050200.96023061
57Influenza A_Homo sapiens_hsa051640.95831023
58Toxoplasmosis_Homo sapiens_hsa051450.95785925
59Phagosome_Homo sapiens_hsa041450.94158514
60Tuberculosis_Homo sapiens_hsa051520.92865682
61Fanconi anemia pathway_Homo sapiens_hsa034600.92732630
62Hepatitis B_Homo sapiens_hsa051610.92442704
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92426651
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92055374
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90609422
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.90518028
67Ribosome_Homo sapiens_hsa030100.88623639
68Bladder cancer_Homo sapiens_hsa052190.88394567
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85693630
70Hedgehog signaling pathway_Homo sapiens_hsa043400.85216387
71Pathways in cancer_Homo sapiens_hsa052000.85202900
72Hepatitis C_Homo sapiens_hsa051600.84319180
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84292364
74MicroRNAs in cancer_Homo sapiens_hsa052060.83548882
75Oxidative phosphorylation_Homo sapiens_hsa001900.83373667
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80979582
77Inositol phosphate metabolism_Homo sapiens_hsa005620.79936846
78Viral myocarditis_Homo sapiens_hsa054160.79594505
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79473542
80Epstein-Barr virus infection_Homo sapiens_hsa051690.79091689
81p53 signaling pathway_Homo sapiens_hsa041150.78669427
82Rap1 signaling pathway_Homo sapiens_hsa040150.78552612
83Legionellosis_Homo sapiens_hsa051340.77845451
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77525686
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77040293
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75807699
87Acute myeloid leukemia_Homo sapiens_hsa052210.74977941
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73912997
89Phenylalanine metabolism_Homo sapiens_hsa003600.72911790
90African trypanosomiasis_Homo sapiens_hsa051430.72508799
91Hippo signaling pathway_Homo sapiens_hsa043900.72067689
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71384845
93Cell cycle_Homo sapiens_hsa041100.70886989
94Choline metabolism in cancer_Homo sapiens_hsa052310.69174913
95Pentose phosphate pathway_Homo sapiens_hsa000300.69127398
96Leishmaniasis_Homo sapiens_hsa051400.68272325
97Sulfur relay system_Homo sapiens_hsa041220.66726222
98Measles_Homo sapiens_hsa051620.65091704
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63547096
100Proteoglycans in cancer_Homo sapiens_hsa052050.62984552
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62130879
102Autoimmune thyroid disease_Homo sapiens_hsa053200.61955511
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61255619
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59741446
105RNA degradation_Homo sapiens_hsa030180.59564623
106Alzheimers disease_Homo sapiens_hsa050100.58977773
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58319991
108RNA polymerase_Homo sapiens_hsa030200.57738509
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57496992
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.56813242
111Folate biosynthesis_Homo sapiens_hsa007900.54989851
112Apoptosis_Homo sapiens_hsa042100.53727492
113DNA replication_Homo sapiens_hsa030300.53057648
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.51394165
115Non-small cell lung cancer_Homo sapiens_hsa052230.51332328
116Endocytosis_Homo sapiens_hsa041440.51219372
117Tryptophan metabolism_Homo sapiens_hsa003800.50814593
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50641693
119Notch signaling pathway_Homo sapiens_hsa043300.50094491
120Homologous recombination_Homo sapiens_hsa034400.49502719
121Mismatch repair_Homo sapiens_hsa034300.47236799
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.47102831
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.46869724
124Antigen processing and presentation_Homo sapiens_hsa046120.45647132
125VEGF signaling pathway_Homo sapiens_hsa043700.42833982
126Adherens junction_Homo sapiens_hsa045200.42285164
127Amoebiasis_Homo sapiens_hsa051460.42120487
128Carbon metabolism_Homo sapiens_hsa012000.41740019
129Parkinsons disease_Homo sapiens_hsa050120.41730788
130Tight junction_Homo sapiens_hsa045300.41503418
131Herpes simplex infection_Homo sapiens_hsa051680.41002373
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.40521459
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40234296
134Mineral absorption_Homo sapiens_hsa049780.40088737
135ECM-receptor interaction_Homo sapiens_hsa045120.38963518
136Complement and coagulation cascades_Homo sapiens_hsa046100.37911403
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37438733
138Protein digestion and absorption_Homo sapiens_hsa049740.37364197
139Chronic myeloid leukemia_Homo sapiens_hsa052200.37104737
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.36197798
141Prostate cancer_Homo sapiens_hsa052150.35869887
142AMPK signaling pathway_Homo sapiens_hsa041520.35000440
143Wnt signaling pathway_Homo sapiens_hsa043100.34768865
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33649614
145Ras signaling pathway_Homo sapiens_hsa040140.33153289
146Biosynthesis of amino acids_Homo sapiens_hsa012300.33008126
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32543409
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31162129
149Glutathione metabolism_Homo sapiens_hsa004800.30922179
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30836153
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.29205450
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.26142871
153Pancreatic cancer_Homo sapiens_hsa052120.25641402
154GnRH signaling pathway_Homo sapiens_hsa049120.24394605
155Small cell lung cancer_Homo sapiens_hsa052220.24220279
156Base excision repair_Homo sapiens_hsa034100.24201622
157Taste transduction_Homo sapiens_hsa047420.20512615
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20512534
159Spliceosome_Homo sapiens_hsa030400.19023656
160Focal adhesion_Homo sapiens_hsa045100.18708774
1612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16438066
162Glycerolipid metabolism_Homo sapiens_hsa005610.15028663
163Adipocytokine signaling pathway_Homo sapiens_hsa049200.14916880
164HTLV-I infection_Homo sapiens_hsa051660.14750082

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