CBR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.72985409
2indole-containing compound catabolic process (GO:0042436)5.72985409
3indolalkylamine catabolic process (GO:0046218)5.72985409
4aromatic amino acid family catabolic process (GO:0009074)5.69008391
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.63901889
6L-phenylalanine metabolic process (GO:0006558)5.63901889
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.62137278
8L-phenylalanine catabolic process (GO:0006559)5.62137278
9detection of molecule of bacterial origin (GO:0032490)5.52139527
10tryptophan metabolic process (GO:0006568)5.43312569
11kynurenine metabolic process (GO:0070189)5.41188069
12exogenous drug catabolic process (GO:0042738)5.07930705
13lysine metabolic process (GO:0006553)4.94364500
14lysine catabolic process (GO:0006554)4.94364500
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.92465994
16drug catabolic process (GO:0042737)4.88844041
17glyoxylate metabolic process (GO:0046487)4.71469495
18amino-acid betaine metabolic process (GO:0006577)4.60251310
19short-chain fatty acid metabolic process (GO:0046459)4.48639860
20DNA double-strand break processing (GO:0000729)4.34813960
21amine catabolic process (GO:0009310)4.31821010
22cellular biogenic amine catabolic process (GO:0042402)4.31821010
23bile acid biosynthetic process (GO:0006699)4.30833999
24coenzyme catabolic process (GO:0009109)4.27269034
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.24644544
26high-density lipoprotein particle remodeling (GO:0034375)4.24243122
27carnitine metabolic process (GO:0009437)4.14341460
28urea metabolic process (GO:0019627)4.13427441
29urea cycle (GO:0000050)4.13427441
30aromatic amino acid family metabolic process (GO:0009072)4.12894822
31alpha-amino acid catabolic process (GO:1901606)4.11787509
32homocysteine metabolic process (GO:0050667)4.10605127
33cellular ketone body metabolic process (GO:0046950)4.08336015
34auditory receptor cell stereocilium organization (GO:0060088)4.08068585
35negative regulation of macroautophagy (GO:0016242)4.07559749
36NAD biosynthetic process (GO:0009435)4.07164977
37indolalkylamine metabolic process (GO:0006586)4.05585967
38regulation of triglyceride catabolic process (GO:0010896)4.03793038
39negative regulation of lipase activity (GO:0060192)3.98466017
40fatty acid beta-oxidation (GO:0006635)3.95883269
41valine metabolic process (GO:0006573)3.91374173
42sulfur amino acid catabolic process (GO:0000098)3.91006420
43energy homeostasis (GO:0097009)3.89473676
44trivalent inorganic anion homeostasis (GO:0072506)3.87090992
45phosphate ion homeostasis (GO:0055062)3.87090992
46alpha-linolenic acid metabolic process (GO:0036109)3.87073529
47branched-chain amino acid catabolic process (GO:0009083)3.85332947
48cellular anion homeostasis (GO:0030002)3.84928045
49nitrogen cycle metabolic process (GO:0071941)3.83925750
50detection of external biotic stimulus (GO:0098581)3.78044320
51positive regulation of glycolytic process (GO:0045821)3.77253527
52cysteine metabolic process (GO:0006534)3.76704823
53phospholipid efflux (GO:0033700)3.73242471
54regulation of fibrinolysis (GO:0051917)3.73061898
55protein-lipid complex remodeling (GO:0034368)3.72426748
56macromolecular complex remodeling (GO:0034367)3.72426748
57plasma lipoprotein particle remodeling (GO:0034369)3.72426748
58fatty acid oxidation (GO:0019395)3.71972427
59cellular amino acid catabolic process (GO:0009063)3.68918128
60negative regulation of fibrinolysis (GO:0051918)3.68066151
61triglyceride homeostasis (GO:0070328)3.66312652
62acylglycerol homeostasis (GO:0055090)3.66312652
63complement activation, alternative pathway (GO:0006957)3.65237367
64bile acid metabolic process (GO:0008206)3.65104129
65lipid oxidation (GO:0034440)3.65088410
66peptidyl-glutamic acid carboxylation (GO:0017187)3.64690753
67protein carboxylation (GO:0018214)3.64690753
68arginine metabolic process (GO:0006525)3.64391947
69nicotinamide nucleotide biosynthetic process (GO:0019359)3.64166519
70pyridine nucleotide biosynthetic process (GO:0019363)3.64166519
71sulfate transmembrane transport (GO:1902358)3.62092029
72water-soluble vitamin biosynthetic process (GO:0042364)3.61889685
73regulation of protein activation cascade (GO:2000257)3.61799962
74dicarboxylic acid biosynthetic process (GO:0043650)3.60892000
75cellular glucuronidation (GO:0052695)3.60371557
76reverse cholesterol transport (GO:0043691)3.59868163
77imidazole-containing compound metabolic process (GO:0052803)3.59146551
78fatty acid catabolic process (GO:0009062)3.57870425
79aspartate family amino acid catabolic process (GO:0009068)3.55245130
80branched-chain amino acid metabolic process (GO:0009081)3.52038013
81biotin metabolic process (GO:0006768)3.51552373
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.51050647
832-oxoglutarate metabolic process (GO:0006103)3.50503386
84regulation of cholesterol esterification (GO:0010872)3.47494978
85ketone body metabolic process (GO:1902224)3.47429638
86regulation of sequestering of triglyceride (GO:0010889)3.47178383
87cofactor catabolic process (GO:0051187)3.46153573
88serine family amino acid catabolic process (GO:0009071)3.45985576
89carboxylic acid catabolic process (GO:0046395)3.45443402
90organic acid catabolic process (GO:0016054)3.45443402
91tyrosine metabolic process (GO:0006570)3.45235936
92respiratory chain complex IV assembly (GO:0008535)3.44771549
93monocarboxylic acid catabolic process (GO:0072329)3.44507274
94bile acid and bile salt transport (GO:0015721)3.42230733
95intraciliary transport (GO:0042073)3.36355732
96acetyl-CoA metabolic process (GO:0006084)3.33025346
97ethanol oxidation (GO:0006069)3.32260266
98benzene-containing compound metabolic process (GO:0042537)3.31871180
99regulation of complement activation (GO:0030449)3.31749566
100NAD metabolic process (GO:0019674)3.27022186
101regulation of hexokinase activity (GO:1903299)3.25722030
102regulation of glucokinase activity (GO:0033131)3.25722030
103post-embryonic morphogenesis (GO:0009886)3.23320306
104aldehyde catabolic process (GO:0046185)3.21195287
105uronic acid metabolic process (GO:0006063)3.20060435
106glucuronate metabolic process (GO:0019585)3.20060435
107regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.19835651
108negative regulation of DNA-dependent DNA replication (GO:2000104)3.15936332
109regulation of meiosis I (GO:0060631)3.11692444
110protein complex biogenesis (GO:0070271)3.08552284
111synapsis (GO:0007129)3.08019523
112presynaptic membrane assembly (GO:0097105)3.02339988
113regulation of acyl-CoA biosynthetic process (GO:0050812)3.01850493
114cullin deneddylation (GO:0010388)3.01583281
115cytochrome complex assembly (GO:0017004)2.98719651
116nonmotile primary cilium assembly (GO:0035058)2.94939143
117chromatin remodeling at centromere (GO:0031055)2.94736939
118mitochondrial respiratory chain complex assembly (GO:0033108)2.94674611
119histone H2A acetylation (GO:0043968)2.93811924
120lactate metabolic process (GO:0006089)2.91581601
121replication fork processing (GO:0031297)2.87151483
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86222999
123proteasome assembly (GO:0043248)2.84246847
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81711600
125CENP-A containing nucleosome assembly (GO:0034080)2.79483339
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76721389
127regulation of mitotic spindle checkpoint (GO:1903504)2.76721389
128regulation of cofactor metabolic process (GO:0051193)2.74585106
129regulation of coenzyme metabolic process (GO:0051196)2.74585106
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.73537235
131NADH dehydrogenase complex assembly (GO:0010257)2.73537235
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73537235
133signal peptide processing (GO:0006465)2.72939508
134histone exchange (GO:0043486)2.72891508
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72631055
136protein prenylation (GO:0018342)2.71723885
137prenylation (GO:0097354)2.71723885
138protein neddylation (GO:0045116)2.70980992
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70453634
140presynaptic membrane organization (GO:0097090)2.70128823
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.69699841
142regulation of translation, ncRNA-mediated (GO:0045974)2.69699841
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69699841
144neural tube formation (GO:0001841)2.69634179
145protein localization to cilium (GO:0061512)2.67340219
146regulation of sulfur metabolic process (GO:0042762)2.65088723
147cilium morphogenesis (GO:0060271)2.59707339
148protein deneddylation (GO:0000338)2.59682147
149limb bud formation (GO:0060174)2.58807167
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58637179
151regulation of nuclear cell cycle DNA replication (GO:0033262)2.55613908
152protein K6-linked ubiquitination (GO:0085020)2.55358601
153photoreceptor cell maintenance (GO:0045494)2.54545856
154somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54231758
155isotype switching (GO:0045190)2.54231758
156somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54231758
157somite rostral/caudal axis specification (GO:0032525)2.53351871
158non-recombinational repair (GO:0000726)2.52904676
159double-strand break repair via nonhomologous end joining (GO:0006303)2.52904676
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.52270804
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52270804
162response to pheromone (GO:0019236)2.51536677
163DNA damage response, detection of DNA damage (GO:0042769)2.50924291
164telomere maintenance via telomerase (GO:0007004)2.50700338
165DNA ligation (GO:0006266)2.49535484
166epithelial cilium movement (GO:0003351)2.48655731
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48546637
168negative regulation of DNA recombination (GO:0045910)2.48179272
169cilium assembly (GO:0042384)2.46153663
170cilium organization (GO:0044782)2.45829682
171DNA catabolic process, exonucleolytic (GO:0000738)2.45718926
172kidney morphogenesis (GO:0060993)2.45538571
173regulation of helicase activity (GO:0051095)2.44952993
174platelet dense granule organization (GO:0060155)2.40718058
175pyrimidine nucleobase catabolic process (GO:0006208)2.40676453
176recombinational repair (GO:0000725)2.40389390
177double-strand break repair via homologous recombination (GO:0000724)2.39568860
178mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39174167
179inositol phosphate catabolic process (GO:0071545)2.38761076
180regulation of mitochondrial translation (GO:0070129)2.37065858
181histone mRNA metabolic process (GO:0008334)2.36977969
182reflex (GO:0060004)2.36429532
183single strand break repair (GO:0000012)2.35286329
184resolution of meiotic recombination intermediates (GO:0000712)2.34564412
185positive regulation of histone H3-K4 methylation (GO:0051571)2.30318212
186peptidyl-histidine modification (GO:0018202)2.28622225
187regulation of cilium movement (GO:0003352)2.27620878
188centriole replication (GO:0007099)2.25594841
189regulation of DNA endoreduplication (GO:0032875)2.23682552
190intra-S DNA damage checkpoint (GO:0031573)2.23155070
191regulation of timing of cell differentiation (GO:0048505)2.22444986
192maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.21619477
193postreplication repair (GO:0006301)2.20952075
194keratinocyte development (GO:0003334)2.20857681
195peptidyl-cysteine modification (GO:0018198)2.20071305
196righting reflex (GO:0060013)2.19563579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.43715299
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36984333
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.22074443
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36616428
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27286086
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.97436887
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.53625963
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.17027135
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94714709
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.82134465
11GBX2_23144817_ChIP-Seq_PC3_Human2.80022228
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.74688893
13ZNF274_21170338_ChIP-Seq_K562_Hela2.71534563
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66059798
15IGF1R_20145208_ChIP-Seq_DFB_Human2.55770012
16FUS_26573619_Chip-Seq_HEK293_Human2.53864505
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.46777429
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35189740
19* GABP_17652178_ChIP-ChIP_JURKAT_Human2.15332199
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12861187
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08452565
22* EST1_17652178_ChIP-ChIP_JURKAT_Human2.08009245
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05565766
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03100314
25VDR_22108803_ChIP-Seq_LS180_Human2.02291875
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99516723
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97509235
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95596625
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92138512
30GATA1_22025678_ChIP-Seq_K562_Human1.91072287
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90029580
32EZH2_22144423_ChIP-Seq_EOC_Human1.89534086
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.88601874
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.87533593
35HTT_18923047_ChIP-ChIP_STHdh_Human1.85297356
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.81673823
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76418279
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.75776303
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71449201
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70510097
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63325879
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62359096
43* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59195011
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56850925
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51435844
46* P300_19829295_ChIP-Seq_ESCs_Human1.49372125
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49271453
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47752938
49TAF15_26573619_Chip-Seq_HEK293_Human1.47545068
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47185814
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45127644
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44477389
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39641327
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39570686
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39491509
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39172150
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37621653
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.35834060
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35770608
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35764515
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33557680
62MYC_18940864_ChIP-ChIP_HL60_Human1.31947280
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31589921
64STAT3_23295773_ChIP-Seq_U87_Human1.31000018
65P53_22387025_ChIP-Seq_ESCs_Mouse1.29463952
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28879266
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28395550
68* VDR_23849224_ChIP-Seq_CD4+_Human1.28277641
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27387827
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27051267
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.26849157
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.26625950
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.26072847
74RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24723958
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23819578
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.23814724
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23197107
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.22215566
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21935055
80IRF1_19129219_ChIP-ChIP_H3396_Human1.21488696
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21089093
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20283384
83TCF4_23295773_ChIP-Seq_U87_Human1.19715614
84RXR_22108803_ChIP-Seq_LS180_Human1.19676965
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19345976
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18988018
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18905482
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18775783
89RNF2_27304074_Chip-Seq_NSC_Mouse1.16267925
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15897346
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.13614019
92CBP_20019798_ChIP-Seq_JUKART_Human1.13331225
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13331225
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12886895
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12697042
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12018244
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.11987268
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11812861
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.10832722
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08979965
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08741789
102* TP53_22573176_ChIP-Seq_HFKS_Human1.08661472
103BCAT_22108803_ChIP-Seq_LS180_Human1.08488218
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.08401681
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08288420
106PU1_27457419_Chip-Seq_LIVER_Mouse1.07683541
107* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05353551
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05062612
109* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04794809
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.04728775
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.04426642
112P300_18555785_Chip-Seq_ESCs_Mouse1.02939887
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.02859223
114TCF4_22108803_ChIP-Seq_LS180_Human1.01774122
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.01756019
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01174230
117* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01147536
118ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00955255
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.00693220
120AR_25329375_ChIP-Seq_VCAP_Human0.99641591
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98138423
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97537800
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97190051
124CBP_21632823_ChIP-Seq_H3396_Human0.96599416
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96151004
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95929242
127EWS_26573619_Chip-Seq_HEK293_Human0.94128290
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94083176
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.93760292
130KLF4_18555785_Chip-Seq_ESCs_Mouse0.91962299
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91279774
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91092362
133* TAL1_26923725_Chip-Seq_HPCs_Mouse0.90855079
134SMAD4_21799915_ChIP-Seq_A2780_Human0.88763479
135STAT1_17558387_ChIP-Seq_HELA_Human0.88351629
136CTCF_18555785_Chip-Seq_ESCs_Mouse0.88330142
137* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88147952
138ER_23166858_ChIP-Seq_MCF-7_Human0.87857058
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.87741254
140AR_20517297_ChIP-Seq_VCAP_Human0.87345820
141SOX2_19829295_ChIP-Seq_ESCs_Human0.86555843
142NANOG_19829295_ChIP-Seq_ESCs_Human0.86555843
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86409142
144* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85955832
145KDM2B_26808549_Chip-Seq_REH_Human0.85570663
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84977809
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84760489
148TP53_18474530_ChIP-ChIP_U2OS_Human0.84376620
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83792738
150* SRF_21415370_ChIP-Seq_HL-1_Mouse0.83750129
151* CDX2_22108803_ChIP-Seq_LS180_Human0.82834575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.00632690
2MP0005085_abnormal_gallbladder_physiolo5.54251659
3MP0005360_urolithiasis5.26064132
4MP0005365_abnormal_bile_salt4.78326906
5MP0009697_abnormal_copulation4.31752477
6MP0005377_hearing/vestibular/ear_phenot4.18627125
7MP0003878_abnormal_ear_physiology4.18627125
8MP0008004_abnormal_stomach_pH4.09343288
9MP0008875_abnormal_xenobiotic_pharmacok3.83046842
10MP0008877_abnormal_DNA_methylation3.18032969
11MP0003806_abnormal_nucleotide_metabolis3.17837382
12MP0003646_muscle_fatigue2.85461948
13MP0010329_abnormal_lipoprotein_level2.80487707
14MP0003252_abnormal_bile_duct2.69835013
15MP0003787_abnormal_imprinting2.64463593
16MP0002102_abnormal_ear_morphology2.38432187
17MP0005332_abnormal_amino_acid2.28649883
18MP0008058_abnormal_DNA_repair2.24612022
19MP0003890_abnormal_embryonic-extraembry2.20240523
20MP0003195_calcinosis2.19243610
21MP0008057_abnormal_DNA_replication2.16537839
22MP0003880_abnormal_central_pattern2.15097897
23MP0006072_abnormal_retinal_apoptosis2.13489604
24MP0001764_abnormal_homeostasis2.10677693
25MP0005670_abnormal_white_adipose2.08763259
26MP0001529_abnormal_vocalization2.07465840
27MP0003121_genomic_imprinting2.06070032
28MP0004019_abnormal_vitamin_homeostasis1.98543625
29MP0001984_abnormal_olfaction1.97936619
30MP0005645_abnormal_hypothalamus_physiol1.97319631
31MP0005083_abnormal_biliary_tract1.91620091
32MP0003122_maternal_imprinting1.90192799
33MP0002736_abnormal_nociception_after1.83176701
34MP0003879_abnormal_hair_cell1.80083989
35MP0003868_abnormal_feces_composition1.76053547
36MP0000631_abnormal_neuroendocrine_gland1.74166794
37MP0005647_abnormal_sex_gland1.71689997
38MP0005319_abnormal_enzyme/_coenzyme1.71395066
39MP0005253_abnormal_eye_physiology1.67876595
40MP0002118_abnormal_lipid_homeostasis1.67089567
41MP0008789_abnormal_olfactory_epithelium1.66301898
42MP0005551_abnormal_eye_electrophysiolog1.65567177
43MP0004133_heterotaxia1.65130628
44MP0001666_abnormal_nutrient_absorption1.59948359
45MP0000566_synostosis1.59236627
46MP0000609_abnormal_liver_physiology1.56396416
47MP0001968_abnormal_touch/_nociception1.54901955
48MP0008995_early_reproductive_senescence1.53530782
49MP0002837_dystrophic_cardiac_calcinosis1.53527834
50MP0002132_abnormal_respiratory_system1.53226496
51MP0002138_abnormal_hepatobiliary_system1.52866358
52MP0003191_abnormal_cellular_cholesterol1.48780263
53MP0002638_abnormal_pupillary_reflex1.47550020
54MP0003718_maternal_effect1.44645895
55MP0003283_abnormal_digestive_organ1.44288158
56MP0005499_abnormal_olfactory_system1.44032221
57MP0005394_taste/olfaction_phenotype1.44032221
58MP0003186_abnormal_redox_activity1.42719489
59MP0010094_abnormal_chromosome_stability1.38681143
60MP0002163_abnormal_gland_morphology1.38345618
61MP0004270_analgesia1.35781799
62MP0000516_abnormal_urinary_system1.35488290
63MP0005367_renal/urinary_system_phenotyp1.35488290
64MP0006036_abnormal_mitochondrial_physio1.34121392
65MP0009046_muscle_twitch1.33710162
66MP0003119_abnormal_digestive_system1.32773877
67MP0000678_abnormal_parathyroid_gland1.31122911
68MP0002751_abnormal_autonomic_nervous1.30849668
69MP0002876_abnormal_thyroid_physiology1.30496827
70MP0006292_abnormal_olfactory_placode1.29829759
71MP0002234_abnormal_pharynx_morphology1.29782098
72MP0005187_abnormal_penis_morphology1.28208385
73MP0003786_premature_aging1.26825748
74MP0005646_abnormal_pituitary_gland1.26659031
75MP0003941_abnormal_skin_development1.25741391
76MP0000372_irregular_coat_pigmentation1.23990545
77MP0001986_abnormal_taste_sensitivity1.19911570
78MP0001293_anophthalmia1.19175313
79MP0002233_abnormal_nose_morphology1.18980936
80MP0005584_abnormal_enzyme/coenzyme_acti1.18380925
81MP0004130_abnormal_muscle_cell1.18347794
82MP0003937_abnormal_limbs/digits/tail_de1.17736546
83MP0004043_abnormal_pH_regulation1.15831931
84MP0001486_abnormal_startle_reflex1.15688957
85MP0009745_abnormal_behavioral_response1.13705189
86MP0006276_abnormal_autonomic_nervous1.13126825
87MP0000749_muscle_degeneration1.12089595
88MP0001485_abnormal_pinna_reflex1.12065056
89MP0002909_abnormal_adrenal_gland1.10300955
90MP0000647_abnormal_sebaceous_gland1.10260603
91MP0009764_decreased_sensitivity_to1.10151403
92MP0005084_abnormal_gallbladder_morpholo1.09665199
93MP0002272_abnormal_nervous_system1.08782189
94MP0000569_abnormal_digit_pigmentation1.07758174
95MP0008775_abnormal_heart_ventricle1.06880531
96MP0010386_abnormal_urinary_bladder1.06158476
97MP0004084_abnormal_cardiac_muscle1.04176368
98MP0002971_abnormal_brown_adipose1.02423790
99MP0005248_abnormal_Harderian_gland1.01788086
100MP0009643_abnormal_urine_homeostasis1.00667158
101MP0000778_abnormal_nervous_system0.99771812
102MP0003567_abnormal_fetal_cardiomyocyte0.99605264
103MP0004215_abnormal_myocardial_fiber0.99168228
104MP0002734_abnormal_mechanical_nocicepti0.96920046
105MP0003137_abnormal_impulse_conducting0.95986048
106MP0002090_abnormal_vision0.94046481
107MP0008872_abnormal_physiological_respon0.93824307
108MP0002254_reproductive_system_inflammat0.93171431
109MP0004142_abnormal_muscle_tone0.93066812
110MP0002557_abnormal_social/conspecific_i0.92190205
111MP0003656_abnormal_erythrocyte_physiolo0.91277026
112MP0001929_abnormal_gametogenesis0.90560063
113MP0000383_abnormal_hair_follicle0.90535104
114MP0002735_abnormal_chemical_nociception0.89962578
115MP0004145_abnormal_muscle_electrophysio0.89845278
116MP0003136_yellow_coat_color0.89153512
117MP0001188_hyperpigmentation0.89017208
118MP0005636_abnormal_mineral_homeostasis0.88644089
119MP0002078_abnormal_glucose_homeostasis0.88455437
120MP0001944_abnormal_pancreas_morphology0.87940042
121MP0005330_cardiomyopathy0.87921732
122MP0005391_vision/eye_phenotype0.86354789
123MP0002210_abnormal_sex_determination0.86133149
124MP0000653_abnormal_sex_gland0.85061564
125MP0003724_increased_susceptibility_to0.84556930
126MP0004924_abnormal_behavior0.81449961
127MP0005386_behavior/neurological_phenoty0.81449961
128MP0005666_abnormal_adipose_tissue0.81224580
129MP0005334_abnormal_fat_pad0.80373213
130MP0003698_abnormal_male_reproductive0.80092167
131MP0009840_abnormal_foam_cell0.80026325
132MP0010678_abnormal_skin_adnexa0.78810985
133MP0001145_abnormal_male_reproductive0.78152466
134MP0005451_abnormal_body_composition0.77484118
135MP0005195_abnormal_posterior_eye0.77160815
136MP0004782_abnormal_surfactant_physiolog0.76841906
137MP0004957_abnormal_blastocyst_morpholog0.76582426
138MP0004036_abnormal_muscle_relaxation0.75515399
139MP0002067_abnormal_sensory_capabilities0.75154415
140MP0008932_abnormal_embryonic_tissue0.73986714
141MP0000230_abnormal_systemic_arterial0.71009560
142MP0008469_abnormal_protein_level0.68998415
143MP0009642_abnormal_blood_homeostasis0.68641308
144MP0004147_increased_porphyrin_level0.66714952
145MP0002938_white_spotting0.66683736
146MP0009763_increased_sensitivity_to0.65661417
147MP0005535_abnormal_body_temperature0.65617057
148MP0006035_abnormal_mitochondrial_morpho0.65152304
149MP0002972_abnormal_cardiac_muscle0.64155083
150MP0000598_abnormal_liver_morphology0.63900994
151MP0004185_abnormal_adipocyte_glucose0.62835546
152MP0003011_delayed_dark_adaptation0.62766899
153MP0002127_abnormal_cardiovascular_syste0.61789645
154MP0006138_congestive_heart_failure0.60836244
155MP0005379_endocrine/exocrine_gland_phen0.59036166
156MP0001756_abnormal_urination0.58544354
157MP0002928_abnormal_bile_duct0.56262601
158MP0001324_abnormal_eye_pigmentation0.53061229
159MP0003953_abnormal_hormone_level0.52843517
160MP0005376_homeostasis/metabolism_phenot0.52603405
161MP0008874_decreased_physiological_sensi0.52008753
162MP0009115_abnormal_fat_cell0.51427598
163MP0005503_abnormal_tendon_morphology0.50761857
164MP0005220_abnormal_exocrine_pancreas0.50125318
165MP0001544_abnormal_cardiovascular_syste0.49550675
166MP0005385_cardiovascular_system_phenoty0.49550675
167MP0005448_abnormal_energy_balance0.48813638
168MP0001881_abnormal_mammary_gland0.46681522
169MP0004085_abnormal_heartbeat0.45530518
170MP0004484_altered_response_of0.45258970
171MP0001661_extended_life_span0.43655599
172MP0002277_abnormal_respiratory_mucosa0.40904405
173MP0005266_abnormal_metabolism0.40839761
174MP0000427_abnormal_hair_cycle0.40543611
175MP0010368_abnormal_lymphatic_system0.40235678
176MP0000639_abnormal_adrenal_gland0.39183166

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.48133574
2Alopecia of scalp (HP:0002293)4.91055918
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.56215213
4Unilateral renal agenesis (HP:0000122)4.46657260
5Hyperammonemia (HP:0001987)4.34991724
6Hyperglycinemia (HP:0002154)4.30557634
7Intrahepatic cholestasis (HP:0001406)4.27880799
8Bilateral sensorineural hearing impairment (HP:0008619)4.18379687
9Follicular hyperkeratosis (HP:0007502)4.15405776
10Hypoglycemic coma (HP:0001325)4.04650003
11Prolonged partial thromboplastin time (HP:0003645)3.95381912
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94697531
13Abnormality of dental color (HP:0011073)3.80970796
14Ketosis (HP:0001946)3.72571024
15Intestinal atresia (HP:0011100)3.58293503
16Abnormality of serine family amino acid metabolism (HP:0010894)3.51190267
17Abnormality of glycine metabolism (HP:0010895)3.51190267
18Deep venous thrombosis (HP:0002625)3.50187483
19Abnormality of pyrimidine metabolism (HP:0004353)3.48038115
20Hypobetalipoproteinemia (HP:0003563)3.47997298
21Dicarboxylic aciduria (HP:0003215)3.45342613
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.45342613
23Abnormality of the labia minora (HP:0012880)3.40167964
24Hyperlipoproteinemia (HP:0010980)3.38641077
25Renal cortical cysts (HP:0000803)3.36879162
26Abnormality of fatty-acid metabolism (HP:0004359)3.35265900
27Xanthomatosis (HP:0000991)3.35221653
28Conjugated hyperbilirubinemia (HP:0002908)3.34498687
29Absent eyelashes (HP:0000561)3.25970467
30Recurrent corneal erosions (HP:0000495)3.21793495
31Abnormality of serum amino acid levels (HP:0003112)3.19452380
32Cheilitis (HP:0100825)3.18453390
33Hyperglycinuria (HP:0003108)3.17684332
34Medial flaring of the eyebrow (HP:0010747)3.13891355
35Hypoalphalipoproteinemia (HP:0003233)3.11833534
36Hypolipoproteinemia (HP:0010981)3.08482252
37Metabolic acidosis (HP:0001942)3.08243808
38Hypoglycemic seizures (HP:0002173)3.07820466
39Cerebral edema (HP:0002181)3.06671592
40Ketoacidosis (HP:0001993)3.03599782
41Absent eyebrow (HP:0002223)3.02339524
42Pancreatic cysts (HP:0001737)3.02018168
43Volvulus (HP:0002580)2.96305088
44Chronic hepatic failure (HP:0100626)2.96158931
45Generalized aminoaciduria (HP:0002909)2.92818825
46Hepatic necrosis (HP:0002605)2.92188228
47Abnormality of methionine metabolism (HP:0010901)2.91732466
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89979404
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88272018
50Joint hemorrhage (HP:0005261)2.86619690
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.85402509
52Colon cancer (HP:0003003)2.85045467
53Progressive macrocephaly (HP:0004481)2.79893832
54True hermaphroditism (HP:0010459)2.75457009
55Pancreatic fibrosis (HP:0100732)2.74977035
56Lethargy (HP:0001254)2.73569625
57Abnormality of midbrain morphology (HP:0002418)2.65174589
58Molar tooth sign on MRI (HP:0002419)2.65174589
59Hypothermia (HP:0002045)2.63132640
60Acute encephalopathy (HP:0006846)2.62281927
61Nephronophthisis (HP:0000090)2.61627932
62Gait imbalance (HP:0002141)2.60203494
63Congenital primary aphakia (HP:0007707)2.60084389
64Mitral stenosis (HP:0001718)2.60014959
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59309221
66Methylmalonic acidemia (HP:0002912)2.58277909
67Complement deficiency (HP:0004431)2.57627060
68Epidermoid cyst (HP:0200040)2.56985728
69Abolished electroretinogram (ERG) (HP:0000550)2.56318908
70Vascular calcification (HP:0004934)2.51947063
71Myoglobinuria (HP:0002913)2.51907584
723-Methylglutaconic aciduria (HP:0003535)2.48870833
73Genital tract atresia (HP:0001827)2.47551151
74Abnormality of nucleobase metabolism (HP:0010932)2.45998779
75Fat malabsorption (HP:0002630)2.45034064
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.42780355
77Hyperinsulinemic hypoglycemia (HP:0000825)2.40450507
78Delayed CNS myelination (HP:0002188)2.37873836
79Nausea (HP:0002018)2.37150140
80Vaginal atresia (HP:0000148)2.35716303
81Increased hepatocellular lipid droplets (HP:0006565)2.32377528
82Proximal tubulopathy (HP:0000114)2.32055760
83Abnormal mitochondria in muscle tissue (HP:0008316)2.31608280
84Nephrogenic diabetes insipidus (HP:0009806)2.31502021
85Abnormal biliary tract physiology (HP:0012439)2.28969691
86Bile duct proliferation (HP:0001408)2.28969691
87Hyperbilirubinemia (HP:0002904)2.28741287
88Gastrointestinal atresia (HP:0002589)2.28654217
89Methylmalonic aciduria (HP:0012120)2.27977653
90Acute necrotizing encephalopathy (HP:0006965)2.27969983
91Abnormality of vitamin B metabolism (HP:0004340)2.27860188
92Pancreatic islet-cell hyperplasia (HP:0004510)2.25607423
93Erythroderma (HP:0001019)2.25531638
94Oligodactyly (hands) (HP:0001180)2.24291469
95Symptomatic seizures (HP:0011145)2.22300188
96Cardiovascular calcification (HP:0011915)2.22164993
97Hepatocellular necrosis (HP:0001404)2.20624825
98Abnormality of the renal medulla (HP:0100957)2.20488659
99Calf muscle hypertrophy (HP:0008981)2.20379588
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.18794160
101Absent/shortened dynein arms (HP:0200106)2.18794160
102Mitochondrial inheritance (HP:0001427)2.16326982
103Abnormality of the common coagulation pathway (HP:0010990)2.15620405
104Neoplasm of the adrenal gland (HP:0100631)2.15296818
105Opisthotonus (HP:0002179)2.14780568
106Vomiting (HP:0002013)2.13335612
107Increased CSF lactate (HP:0002490)2.13144888
108Neoplasm of the adrenal cortex (HP:0100641)2.12401849
109Lactic acidosis (HP:0003128)2.12271128
110Abnormality of urine glucose concentration (HP:0011016)2.11447336
111Glycosuria (HP:0003076)2.11447336
112Abnormality of the intrinsic pathway (HP:0010989)2.11263131
113Abnormality of chromosome stability (HP:0003220)2.10556521
114Tubulointerstitial nephritis (HP:0001970)2.09304308
115Hypercholesterolemia (HP:0003124)2.07971663
116Aplasia/Hypoplasia of the uvula (HP:0010293)2.06632444
117Abnormality of the renal cortex (HP:0011035)2.06570202
118Microvesicular hepatic steatosis (HP:0001414)2.06247096
119Lipid accumulation in hepatocytes (HP:0006561)2.05701055
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04196401
121Abnormality of alanine metabolism (HP:0010916)2.04196401
122Hyperalaninemia (HP:0003348)2.04196401
123Progressive inability to walk (HP:0002505)2.03962207
124Increased muscle lipid content (HP:0009058)2.03067509
125Absent hair (HP:0002298)2.01098735
126Chronic otitis media (HP:0000389)2.00064880
127Meckel diverticulum (HP:0002245)1.96588139
128Enlarged kidneys (HP:0000105)1.96396404
129Abnormality of purine metabolism (HP:0004352)1.94979112
130Abnormality of the ileum (HP:0001549)1.94270760
131Steatorrhea (HP:0002570)1.92986399
132Muscle hypertrophy of the lower extremities (HP:0008968)1.92392071
133Hyperventilation (HP:0002883)1.91975192
134Abnormality of the vitamin B12 metabolism (HP:0004341)1.91244690
135Poor coordination (HP:0002370)1.90239031
136Glioma (HP:0009733)1.87300547
137Labial hypoplasia (HP:0000066)1.85815740
138Abnormality of the pancreatic islet cells (HP:0006476)1.85159664
139Abnormality of endocrine pancreas physiology (HP:0012093)1.85159664
140Ependymoma (HP:0002888)1.83845122
141Male pseudohermaphroditism (HP:0000037)1.82993364
142Postaxial hand polydactyly (HP:0001162)1.81746709
143Gaze-evoked nystagmus (HP:0000640)1.81178594
144Aqueductal stenosis (HP:0002410)1.81173470
145Bifid tongue (HP:0010297)1.80824453
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.80408995
147Astrocytoma (HP:0009592)1.78761915
148Abnormality of the astrocytes (HP:0100707)1.78761915
149Abnormality of the duodenum (HP:0002246)1.78119578
150Congenital malformation of the right heart (HP:0011723)1.77261207
151Double outlet right ventricle (HP:0001719)1.77261207
152Abnormal lung lobation (HP:0002101)1.76736839
153Large for gestational age (HP:0001520)1.75295833
154Hypoplastic female external genitalia (HP:0012815)1.73745973
155Biliary tract neoplasm (HP:0100574)1.71933819
156Supernumerary spleens (HP:0009799)1.70281407
157Hyperglycemia (HP:0003074)1.69199688
158Increased serum lactate (HP:0002151)1.68810033
159Broad-based gait (HP:0002136)1.68619398
160Postaxial foot polydactyly (HP:0001830)1.66747454
161Preaxial hand polydactyly (HP:0001177)1.66117843
162Renal hypoplasia (HP:0000089)1.65063110
163Gonadotropin excess (HP:0000837)1.64338123
164Increased serum pyruvate (HP:0003542)1.63949321
165Optic nerve hypoplasia (HP:0000609)1.63669365
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.63417731
167Abnormality of the metopic suture (HP:0005556)1.63408874
168Sclerocornea (HP:0000647)1.62355028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK37.79109147
2SIK15.50331582
3WNK33.75694486
4SIK23.58894398
5BCKDK3.40494213
6STK38L3.30169280
7INSRR2.83692590
8MAP4K22.68874063
9MARK32.66039164
10MKNK22.55615005
11TRIM282.53772986
12ACVR1B2.51825016
13LATS12.30712605
14NEK92.27304921
15MKNK12.02795530
16MST42.01043130
17MAP3K41.89647750
18EIF2AK31.78361114
19EPHA21.76402203
20BCR1.76265196
21BRSK21.75445585
22IRAK31.75010886
23PLK31.72106806
24MAP3K121.70091843
25MAPK131.66393479
26ZAK1.66275120
27PLK21.62155742
28STK161.59982948
29FGFR21.54152944
30FRK1.46764261
31CDK81.44394196
32STK241.42896606
33PLK41.41765550
34OBSCN1.34827490
35PIK3CA1.34094138
36MYLK1.32432994
37BUB11.32042130
38NEK11.25830515
39PNCK1.22515037
40SGK21.22066745
41CASK1.15185598
42PAK31.15099371
43MAP3K141.14440007
44TTK1.12308375
45MST1R1.11516454
46OXSR11.09089794
47TSSK61.07711596
48TXK1.07344176
49CSNK1G11.06962497
50ADRBK21.06232345
51PINK11.05576468
52CSNK1G21.00526320
53FLT31.00155726
54TAOK20.99569584
55NUAK10.98378018
56MAP2K70.97351570
57MARK10.95082896
58EIF2AK10.94983794
59NME20.93520258
60PASK0.93517679
61WEE10.92698616
62CDC70.92512429
63STK390.90064842
64PRKCE0.89872416
65TNIK0.89710347
66PDK30.89385390
67PDK40.89385390
68FER0.88542029
69MAP2K40.88448539
70CSNK1G30.85882203
71TAOK30.85762205
72EIF2AK20.85550474
73DYRK20.83953881
74PLK10.83791499
75PHKG20.83410444
76PHKG10.83410444
77PIK3CG0.83020387
78PRKAA20.82553339
79PRKCG0.81898906
80STK30.78896216
81PAK40.78891754
82SRPK10.76245641
83VRK20.76149135
84PRPF4B0.76038305
85TAF10.74786113
86CAMK40.73721177
87CAMK10.72953183
88FGFR10.72285707
89MUSK0.71890328
90TGFBR10.71444435
91SGK30.71276220
92CSNK1A1L0.70737283
93GRK70.68679944
94MAPK110.68440576
95FGFR40.64956989
96CAMK1D0.64113372
97TEC0.63816305
98CCNB10.62292707
99BMPR20.61037536
100ATM0.59646659
101STK380.58715694
102MAP3K50.55999012
103NTRK30.55417712
104DYRK30.53747515
105MINK10.52804567
106TYK20.52554401
107YES10.51400807
108BRSK10.50882067
109PRKAA10.50864553
110SGK2230.50779853
111SGK4940.50779853
112JAK10.50667115
113PBK0.50448808
114ATR0.49755702
115IRAK40.48222042
116BRD40.47469293
117CDK30.46864313
118ERBB40.46262556
119MAP2K60.45638541
120VRK10.43873805
121TIE10.43435750
122CAMK2A0.42965715
123BMPR1B0.42474988
124CAMKK20.41233961
125TRPM70.40225766
126ABL20.39558248
127CSNK1E0.38881571
128EPHA30.38794775
129CSNK1A10.38353460
130UHMK10.38069453
131WNK40.37597177
132EPHA40.36434614
133ERBB30.36423203
134ADRBK10.36337329
135PDK20.36208902
136CDK190.35534863
137CSNK1D0.34630302
138CHEK20.34614723
139PRKACB0.33795766
140PRKG10.33766129
141NME10.33188612
142PRKDC0.33017969
143NLK0.32795252
144MAP3K70.32306038
145JAK30.30936679
146STK40.30751875
147TNK20.30298971
148ERBB20.30259133
149RPS6KB10.30042976
150PRKCQ0.29549125
151CAMK2G0.28316310
152MAP3K110.26389606
153RPS6KA40.26128281
154IRAK10.26023808
155PRKACG0.25424430
156DAPK20.25272184
157CDK70.25102685
158MAPK40.25086560
159CSNK2A10.24951481
160GRK10.24457319
161AKT30.23918805
162PRKACA0.21538319
163PRKCZ0.20610512
164SGK10.20481111

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60146926
2Propanoate metabolism_Homo sapiens_hsa006403.01040954
3Fatty acid degradation_Homo sapiens_hsa000713.00184004
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95631201
5Arginine biosynthesis_Homo sapiens_hsa002202.93008465
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64661583
7Tryptophan metabolism_Homo sapiens_hsa003802.56785045
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54146414
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50888857
10Non-homologous end-joining_Homo sapiens_hsa034502.47714960
11Peroxisome_Homo sapiens_hsa041462.43074693
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28649544
13Fatty acid metabolism_Homo sapiens_hsa012122.20104972
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.16635043
15Caffeine metabolism_Homo sapiens_hsa002322.13055404
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11996349
17Butanoate metabolism_Homo sapiens_hsa006502.03222712
18Chemical carcinogenesis_Homo sapiens_hsa052042.03141363
19Complement and coagulation cascades_Homo sapiens_hsa046102.02872478
20Basal transcription factors_Homo sapiens_hsa030221.97593551
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95497620
22Nitrogen metabolism_Homo sapiens_hsa009101.94820424
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91557435
24Proteasome_Homo sapiens_hsa030501.88547351
25Sulfur metabolism_Homo sapiens_hsa009201.87126891
26beta-Alanine metabolism_Homo sapiens_hsa004101.85754548
27Fanconi anemia pathway_Homo sapiens_hsa034601.82692349
28PPAR signaling pathway_Homo sapiens_hsa033201.81389567
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81021473
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79585742
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76658754
32Fatty acid elongation_Homo sapiens_hsa000621.76299101
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74913603
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74642556
35Mismatch repair_Homo sapiens_hsa034301.71818152
36RNA degradation_Homo sapiens_hsa030181.66410278
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.66035635
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64536106
39Retinol metabolism_Homo sapiens_hsa008301.63860674
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60017609
41Pyruvate metabolism_Homo sapiens_hsa006201.58856948
42RNA polymerase_Homo sapiens_hsa030201.57518155
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57142669
44Histidine metabolism_Homo sapiens_hsa003401.52757824
45Phototransduction_Homo sapiens_hsa047441.52483091
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43964787
47Starch and sucrose metabolism_Homo sapiens_hsa005001.43449714
48Folate biosynthesis_Homo sapiens_hsa007901.41169813
49Carbon metabolism_Homo sapiens_hsa012001.39883528
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39000744
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38475169
52Staphylococcus aureus infection_Homo sapiens_hsa051501.36063294
53Sulfur relay system_Homo sapiens_hsa041221.33498680
54Phenylalanine metabolism_Homo sapiens_hsa003601.31009904
55Selenocompound metabolism_Homo sapiens_hsa004501.27846967
56Nicotine addiction_Homo sapiens_hsa050331.21724872
57Oxidative phosphorylation_Homo sapiens_hsa001901.20414112
58Tyrosine metabolism_Homo sapiens_hsa003501.16111738
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15782184
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13938941
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.13223310
62RNA transport_Homo sapiens_hsa030131.12539292
63Arginine and proline metabolism_Homo sapiens_hsa003301.10401339
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.02535893
65Lysine degradation_Homo sapiens_hsa003101.01909296
66Nucleotide excision repair_Homo sapiens_hsa034200.99914405
67Parkinsons disease_Homo sapiens_hsa050120.98254987
68ABC transporters_Homo sapiens_hsa020100.95463824
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90761292
70Ether lipid metabolism_Homo sapiens_hsa005650.90492228
71Oocyte meiosis_Homo sapiens_hsa041140.90205262
72Fat digestion and absorption_Homo sapiens_hsa049750.89329765
73Vitamin digestion and absorption_Homo sapiens_hsa049770.85698252
74DNA replication_Homo sapiens_hsa030300.83907305
75Regulation of autophagy_Homo sapiens_hsa041400.82781631
76Taste transduction_Homo sapiens_hsa047420.81741647
77Biosynthesis of amino acids_Homo sapiens_hsa012300.80175133
78One carbon pool by folate_Homo sapiens_hsa006700.79866649
79Bile secretion_Homo sapiens_hsa049760.76641033
80Insulin secretion_Homo sapiens_hsa049110.75701481
81Metabolic pathways_Homo sapiens_hsa011000.75624443
82Steroid biosynthesis_Homo sapiens_hsa001000.75111339
83Spliceosome_Homo sapiens_hsa030400.74224849
84Fatty acid biosynthesis_Homo sapiens_hsa000610.68437532
85Alzheimers disease_Homo sapiens_hsa050100.68423721
86Collecting duct acid secretion_Homo sapiens_hsa049660.66774628
87Huntingtons disease_Homo sapiens_hsa050160.66004188
88Glycerolipid metabolism_Homo sapiens_hsa005610.65582488
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65556415
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64192672
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63266385
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61651536
93Cell cycle_Homo sapiens_hsa041100.61107281
94Olfactory transduction_Homo sapiens_hsa047400.59920172
95Base excision repair_Homo sapiens_hsa034100.59298001
96GABAergic synapse_Homo sapiens_hsa047270.59243308
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.53733985
98Serotonergic synapse_Homo sapiens_hsa047260.52486492
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51301346
100Glutathione metabolism_Homo sapiens_hsa004800.50758278
101Glutamatergic synapse_Homo sapiens_hsa047240.49280567
102Dopaminergic synapse_Homo sapiens_hsa047280.48340078
103Circadian entrainment_Homo sapiens_hsa047130.47240142
104TGF-beta signaling pathway_Homo sapiens_hsa043500.47141924
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46752213
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45629993
107Linoleic acid metabolism_Homo sapiens_hsa005910.45309834
108mRNA surveillance pathway_Homo sapiens_hsa030150.43552335
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42597569
110Cardiac muscle contraction_Homo sapiens_hsa042600.36555894
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35327891
112Pentose phosphate pathway_Homo sapiens_hsa000300.34249712
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34153695
114Mineral absorption_Homo sapiens_hsa049780.33720665
115Galactose metabolism_Homo sapiens_hsa000520.29034427
116Arachidonic acid metabolism_Homo sapiens_hsa005900.28172915
117Homologous recombination_Homo sapiens_hsa034400.25120152
118Protein export_Homo sapiens_hsa030600.24607582
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23225004
120Fructose and mannose metabolism_Homo sapiens_hsa000510.21356498
121Insulin resistance_Homo sapiens_hsa049310.17801397
122Ovarian steroidogenesis_Homo sapiens_hsa049130.17051636
123Glucagon signaling pathway_Homo sapiens_hsa049220.13803778
124Pyrimidine metabolism_Homo sapiens_hsa002400.12531099
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12472431
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.12393803
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12116898
128Vitamin B6 metabolism_Homo sapiens_hsa007500.10915859
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06979227
130Circadian rhythm_Homo sapiens_hsa047100.05399596
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.05386899
132African trypanosomiasis_Homo sapiens_hsa051430.04454400
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.02020882
134Calcium signaling pathway_Homo sapiens_hsa04020-0.0485343
135Purine metabolism_Homo sapiens_hsa00230-0.0405619
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0193423
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0087787

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