CBSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)6.49691085
2protein complex localization (GO:0031503)4.69212081
3heterochromatin organization (GO:0070828)4.62581023
4serine family amino acid biosynthetic process (GO:0009070)4.46653944
5DNA unwinding involved in DNA replication (GO:0006268)4.46432967
6establishment of integrated proviral latency (GO:0075713)4.36059051
7regulation of gene silencing by RNA (GO:0060966)4.32228862
8regulation of posttranscriptional gene silencing (GO:0060147)4.32228862
9regulation of gene silencing by miRNA (GO:0060964)4.32228862
10pre-miRNA processing (GO:0031054)4.23828982
11protein localization to kinetochore (GO:0034501)4.19229613
12DNA strand elongation involved in DNA replication (GO:0006271)4.13987803
13cellular protein complex localization (GO:0034629)4.02793285
14DNA strand elongation (GO:0022616)3.97124222
15paraxial mesoderm development (GO:0048339)3.93454753
16histone arginine methylation (GO:0034969)3.76066382
17chromatin remodeling at centromere (GO:0031055)3.64643391
18DNA replication checkpoint (GO:0000076)3.57594904
19protein localization to chromosome, centromeric region (GO:0071459)3.57562309
20IMP biosynthetic process (GO:0006188)3.46904380
21DNA replication-dependent nucleosome assembly (GO:0006335)3.42784349
22DNA replication-dependent nucleosome organization (GO:0034723)3.42784349
23glycine metabolic process (GO:0006544)3.42060574
24DNA replication initiation (GO:0006270)3.41547422
25CENP-A containing nucleosome assembly (GO:0034080)3.40912015
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40183030
27peptidyl-arginine omega-N-methylation (GO:0035247)3.34348986
28telomere maintenance via semi-conservative replication (GO:0032201)3.34187735
29mitotic sister chromatid segregation (GO:0000070)3.34160819
30positive regulation of SMAD protein import into nucleus (GO:0060391)3.26109655
31nucleobase biosynthetic process (GO:0046112)3.21322124
32regulation of translational fidelity (GO:0006450)3.19977199
33establishment of viral latency (GO:0019043)3.17251126
34DNA replication-independent nucleosome assembly (GO:0006336)3.16927653
35DNA replication-independent nucleosome organization (GO:0034724)3.16927653
36purine nucleobase biosynthetic process (GO:0009113)3.15681314
37IMP metabolic process (GO:0046040)3.15522642
38mitotic metaphase plate congression (GO:0007080)3.13053783
39convergent extension (GO:0060026)3.09870679
40sister chromatid segregation (GO:0000819)3.08562952
41chromatin assembly (GO:0031497)3.03793821
42regulation of cell fate specification (GO:0042659)3.01618223
43negative regulation of mRNA processing (GO:0050686)2.98596874
44serine family amino acid catabolic process (GO:0009071)2.98140372
45histone exchange (GO:0043486)2.95222605
46ATP-dependent chromatin remodeling (GO:0043044)2.94307366
47negative regulation of chromosome segregation (GO:0051985)2.88721727
48serine family amino acid metabolic process (GO:0009069)2.87898732
49peptidyl-arginine N-methylation (GO:0035246)2.87843242
50peptidyl-arginine methylation (GO:0018216)2.87843242
51chromatin assembly or disassembly (GO:0006333)2.87657377
52L-alpha-amino acid transmembrane transport (GO:1902475)2.87534032
53lung-associated mesenchyme development (GO:0060484)2.82331322
54nuclear pore complex assembly (GO:0051292)2.81743021
55protein-DNA complex disassembly (GO:0032986)2.80999058
56nucleosome disassembly (GO:0006337)2.80999058
57negative regulation of RNA splicing (GO:0033119)2.80527364
58negative regulation of mRNA metabolic process (GO:1903312)2.80484313
59homocysteine metabolic process (GO:0050667)2.79484408
60regulation of stem cell maintenance (GO:2000036)2.79459292
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79063700
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79063700
63negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79063700
64negative regulation of mitotic sister chromatid separation (GO:2000816)2.79063700
65negative regulation of sister chromatid segregation (GO:0033046)2.79063700
66mitotic chromosome condensation (GO:0007076)2.77769946
67DNA damage response, detection of DNA damage (GO:0042769)2.77489452
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75173380
69nuclear pore organization (GO:0006999)2.71939860
70positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.69471518
71positive regulation of cell cycle G2/M phase transition (GO:1902751)2.69471518
72folic acid-containing compound biosynthetic process (GO:0009396)2.68679290
73outer ear morphogenesis (GO:0042473)2.68660585
74negative regulation of telomerase activity (GO:0051974)2.68024649
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65735764
76telomere maintenance via recombination (GO:0000722)2.65521723
77formation of translation preinitiation complex (GO:0001731)2.62882677
78spindle checkpoint (GO:0031577)2.62394657
79tetrahydrofolate metabolic process (GO:0046653)2.62093586
80positive regulation of chromosome segregation (GO:0051984)2.59278785
81cell fate commitment involved in formation of primary germ layer (GO:0060795)2.58263708
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.57927317
83mitotic recombination (GO:0006312)2.56606310
84DNA duplex unwinding (GO:0032508)2.56069901
85regulation of chromosome segregation (GO:0051983)2.55172802
86regulation of helicase activity (GO:0051095)2.54407313
87mitotic spindle checkpoint (GO:0071174)2.53152737
88glutamine metabolic process (GO:0006541)2.52717408
89mitotic sister chromatid cohesion (GO:0007064)2.52122929
90DNA strand renaturation (GO:0000733)2.51550786
91DNA topological change (GO:0006265)2.50306648
92mitotic spindle assembly checkpoint (GO:0007094)2.50040865
93base-excision repair (GO:0006284)2.49471903
94negative regulation of androgen receptor signaling pathway (GO:0060766)2.49375027
95anterior/posterior axis specification, embryo (GO:0008595)2.48248397
96DNA geometric change (GO:0032392)2.47842737
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47134449
98metaphase plate congression (GO:0051310)2.45403776
99spindle assembly checkpoint (GO:0071173)2.44557030
100negative regulation of mitosis (GO:0045839)2.43870517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70861912
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.02996767
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.58332746
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98521688
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97663935
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97380532
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81629501
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71176486
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66286139
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48436301
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.38677780
12AR_21909140_ChIP-Seq_LNCAP_Human2.30773220
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27101714
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27101714
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27101714
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.25654593
17XRN2_22483619_ChIP-Seq_HELA_Human2.24421868
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23604557
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21903609
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17731647
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06312550
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03820838
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00079760
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98716489
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.97469889
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93735462
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93562634
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.91803476
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91742794
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89214789
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88664811
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88134717
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86628191
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85138638
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80588103
36TTF2_22483619_ChIP-Seq_HELA_Human1.79509111
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77355857
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74941754
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69750596
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.67637777
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.66880569
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66185152
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63545709
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62350059
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56832314
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54768762
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.54057800
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.53277637
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51203450
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49884841
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49845326
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38035753
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35950974
54NANOG_21062744_ChIP-ChIP_HESCs_Human1.35924873
55GABP_19822575_ChIP-Seq_HepG2_Human1.32846489
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.30862155
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.28699820
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.28576585
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27924807
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25203935
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24820447
62DCP1A_22483619_ChIP-Seq_HELA_Human1.24704359
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24461307
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23744734
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23286447
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22799831
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.22306700
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21486699
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20026182
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18358547
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15050070
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14225292
73FOXP3_21729870_ChIP-Seq_TREG_Human1.12257534
74OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10211518
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09635703
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08538145
77SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04872671
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04461544
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.03766736
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03535778
81MYC_18940864_ChIP-ChIP_HL60_Human1.02998158
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02986514
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02387362
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01357436
85KDM5A_27292631_Chip-Seq_BREAST_Human1.00646323
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00227033
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99792055
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96831934
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96015450
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95272364
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94000680
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92515780
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91712206
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91665297
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90951537
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90396111
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90373803
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.89452868
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89216671
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87156466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.54022698
2MP0003111_abnormal_nucleus_morphology3.11634949
3MP0004957_abnormal_blastocyst_morpholog3.01440943
4MP0002254_reproductive_system_inflammat2.98946583
5MP0010094_abnormal_chromosome_stability2.85011055
6MP0006292_abnormal_olfactory_placode2.77657080
7MP0010030_abnormal_orbit_morphology2.73219766
8MP0003941_abnormal_skin_development2.62946179
9MP0008932_abnormal_embryonic_tissue2.54396655
10MP0000537_abnormal_urethra_morphology2.38599349
11MP0003077_abnormal_cell_cycle2.24660436
12MP0009672_abnormal_birth_weight2.20354092
13MP0001293_anophthalmia2.15834410
14MP0003890_abnormal_embryonic-extraembry2.13174871
15MP0003937_abnormal_limbs/digits/tail_de1.97945768
16MP0001730_embryonic_growth_arrest1.96297123
17MP0008058_abnormal_DNA_repair1.91631458
18MP0000049_abnormal_middle_ear1.90870101
19MP0002697_abnormal_eye_size1.89697662
20MP0004133_heterotaxia1.85803564
21MP0000566_synostosis1.72052922
22MP0003119_abnormal_digestive_system1.70476614
23MP0002085_abnormal_embryonic_tissue1.65875796
24MP0003283_abnormal_digestive_organ1.60336094
25MP0008057_abnormal_DNA_replication1.58591583
26MP0002084_abnormal_developmental_patter1.55961939
27MP0003567_abnormal_fetal_cardiomyocyte1.54986785
28MP0002938_white_spotting1.49680121
29MP0001672_abnormal_embryogenesis/_devel1.48853993
30MP0005380_embryogenesis_phenotype1.48853993
31MP0000350_abnormal_cell_proliferation1.48377721
32MP0003136_yellow_coat_color1.45921616
33MP0008007_abnormal_cellular_replicative1.40051163
34MP0003705_abnormal_hypodermis_morpholog1.39867823
35MP0009053_abnormal_anal_canal1.39706877
36MP0004858_abnormal_nervous_system1.38549906
37MP0002249_abnormal_larynx_morphology1.38060654
38MP0003861_abnormal_nervous_system1.35755276
39MP0003942_abnormal_urinary_system1.33544824
40MP0001299_abnormal_eye_distance/1.31463217
41MP0000428_abnormal_craniofacial_morphol1.30626323
42MP0003315_abnormal_perineum_morphology1.29076150
43MP0001286_abnormal_eye_development1.28844486
44MP0002233_abnormal_nose_morphology1.28000568
45MP0001697_abnormal_embryo_size1.26975754
46MP0003984_embryonic_growth_retardation1.25662158
47MP0002111_abnormal_tail_morphology1.24664869
48MP0001188_hyperpigmentation1.22102739
49MP0002088_abnormal_embryonic_growth/wei1.20066183
50MP0002080_prenatal_lethality1.19347698
51MP0003123_paternal_imprinting1.18025355
52MP0005623_abnormal_meninges_morphology1.14979333
53MP0002092_abnormal_eye_morphology1.13503297
54MP0001346_abnormal_lacrimal_gland1.13352188
55MP0003718_maternal_effect1.12361867
56MP0005187_abnormal_penis_morphology1.12247011
57MP0004197_abnormal_fetal_growth/weight/1.11480353
58MP0003938_abnormal_ear_development1.11152213
59MP0004272_abnormal_basement_membrane1.09676801
60MP0009703_decreased_birth_body1.08423786
61MP0000678_abnormal_parathyroid_gland1.07470763
62MP0005499_abnormal_olfactory_system1.05782562
63MP0005394_taste/olfaction_phenotype1.05782562
64MP0004233_abnormal_muscle_weight1.05419198
65MP0001529_abnormal_vocalization1.03587083
66MP0003121_genomic_imprinting1.02253058
67MP0003122_maternal_imprinting1.01602277
68MP0008877_abnormal_DNA_methylation1.01136361
69MP0003755_abnormal_palate_morphology1.00453524
70MP0004859_abnormal_synaptic_plasticity1.00024871
71MP0003878_abnormal_ear_physiology0.99661242
72MP0005377_hearing/vestibular/ear_phenot0.99661242
73MP0001849_ear_inflammation0.99656078
74MP0002234_abnormal_pharynx_morphology0.99016113
75MP0003385_abnormal_body_wall0.98380478
76MP0000432_abnormal_head_morphology0.98012898
77MP0002653_abnormal_ependyma_morphology0.97642506
78MP0000778_abnormal_nervous_system0.96309772
79MP0004185_abnormal_adipocyte_glucose0.93146682
80MP0000579_abnormal_nail_morphology0.92843766
81MP0003935_abnormal_craniofacial_develop0.92013741
82MP0008789_abnormal_olfactory_epithelium0.91217850
83MP0010352_gastrointestinal_tract_polyps0.89922546
84MP0009250_abnormal_appendicular_skeleto0.88551296
85MP0003115_abnormal_respiratory_system0.87337493
86MP0002116_abnormal_craniofacial_bone0.84083154
87MP0002086_abnormal_extraembryonic_tissu0.82837147
88MP0002081_perinatal_lethality0.82671269
89MP0002152_abnormal_brain_morphology0.81783678
90MP0002736_abnormal_nociception_after0.81715776
91MP0000762_abnormal_tongue_morphology0.79166988
92MP0000631_abnormal_neuroendocrine_gland0.78507318
93MP0002751_abnormal_autonomic_nervous0.77231587
94MP0000955_abnormal_spinal_cord0.77040225
95MP0000313_abnormal_cell_death0.75946996
96MP0006035_abnormal_mitochondrial_morpho0.73475185
97MP0000534_abnormal_ureter_morphology0.71132932
98MP0002089_abnormal_postnatal_growth/wei0.70754224
99MP0005257_abnormal_intraocular_pressure0.69624886
100MP0002114_abnormal_axial_skeleton0.69535747

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.12096732
2Abnormality of the labia minora (HP:0012880)3.10592510
3Hepatoblastoma (HP:0002884)3.05633399
4Septo-optic dysplasia (HP:0100842)2.92856580
5Colon cancer (HP:0003003)2.91868178
6Birth length less than 3rd percentile (HP:0003561)2.81768686
7Choanal stenosis (HP:0000452)2.79472802
8Partial duplication of thumb phalanx (HP:0009944)2.78627680
9Abnormal lung lobation (HP:0002101)2.72069236
10Multiple enchondromatosis (HP:0005701)2.62696891
11Reticulocytopenia (HP:0001896)2.61432096
12Spastic diplegia (HP:0001264)2.61165943
13Abnormal number of incisors (HP:0011064)2.55641312
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54553456
15High anterior hairline (HP:0009890)2.52592096
16Duplication of thumb phalanx (HP:0009942)2.52113779
17Partial duplication of the phalanx of hand (HP:0009999)2.49981005
18Increased nuchal translucency (HP:0010880)2.44711257
19Bilateral microphthalmos (HP:0007633)2.42306452
20Selective tooth agenesis (HP:0001592)2.36045800
21Hyperglycinemia (HP:0002154)2.35584822
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31807557
23Absent radius (HP:0003974)2.31710779
24Chromsome breakage (HP:0040012)2.31220399
25Ectopic kidney (HP:0000086)2.24835386
26Facial cleft (HP:0002006)2.23800770
27Turricephaly (HP:0000262)2.22066340
28Aplasia involving forearm bones (HP:0009822)2.19785170
29Absent forearm bone (HP:0003953)2.19785170
30Abnormality of the phalanges of the hallux (HP:0010057)2.14521519
31Broad thumb (HP:0011304)2.12042679
32Cutaneous syndactyly (HP:0012725)2.08962208
33Maternal diabetes (HP:0009800)2.08924771
34Bifid tongue (HP:0010297)2.07538396
35Generalized hypotonia (HP:0001290)2.06975428
36Esophageal atresia (HP:0002032)2.06773113
37Broad distal phalanx of finger (HP:0009836)2.06500866
38Abnormality of cochlea (HP:0000375)2.05159828
39Nephroblastoma (Wilms tumor) (HP:0002667)2.04743298
40Meckel diverticulum (HP:0002245)2.04238858
41Abnormality of serine family amino acid metabolism (HP:0010894)2.03921382
42Abnormality of glycine metabolism (HP:0010895)2.03921382
43Homocystinuria (HP:0002156)2.02991084
44Abnormality of homocysteine metabolism (HP:0010919)2.02991084
45Rectal fistula (HP:0100590)2.00817823
46Rectovaginal fistula (HP:0000143)2.00817823
47Abnormality of the middle phalanges of the toes (HP:0010183)2.00659892
48Cutaneous finger syndactyly (HP:0010554)1.98754468
49Vaginal fistula (HP:0004320)1.98535677
50Aplasia/Hypoplasia of the sternum (HP:0006714)1.98308003
51Shallow orbits (HP:0000586)1.97982688
52Hyperglycinuria (HP:0003108)1.95030367
53Embryonal renal neoplasm (HP:0011794)1.93117113
54Horseshoe kidney (HP:0000085)1.92339982
55Myelomeningocele (HP:0002475)1.91200225
56Abnormality of the ileum (HP:0001549)1.90611116
57Coronal craniosynostosis (HP:0004440)1.90172700
58Trigonocephaly (HP:0000243)1.88917630
59Intestinal fistula (HP:0100819)1.85127258
60Triphalangeal thumb (HP:0001199)1.84956159
61Overriding aorta (HP:0002623)1.84464924
62Absent septum pellucidum (HP:0001331)1.83788020
63Preaxial foot polydactyly (HP:0001841)1.83657387
64Transposition of the great arteries (HP:0001669)1.82881805
65Abnormal connection of the cardiac segments (HP:0011545)1.82881805
66Abnormal ventriculo-arterial connection (HP:0011563)1.82881805
67Absent eyelashes (HP:0000561)1.81643810
68Abnormality of serum amino acid levels (HP:0003112)1.77863941
69Skull defect (HP:0001362)1.75372619
70Abnormality of the septum pellucidum (HP:0007375)1.75220568
71Broad phalanges of the hand (HP:0009768)1.74673531
72Anophthalmia (HP:0000528)1.73797527
73Neoplasm of the adrenal cortex (HP:0100641)1.73472309
74Atresia of the external auditory canal (HP:0000413)1.72804437
75Aplasia/Hypoplasia of the breasts (HP:0010311)1.72613605
76Stenosis of the external auditory canal (HP:0000402)1.72103371
77Preauricular skin tag (HP:0000384)1.71103059
78Impulsivity (HP:0100710)1.70177733
79Pancreatic islet-cell hyperplasia (HP:0004510)1.69880811
80Carpal bone hypoplasia (HP:0001498)1.68913100
81Breast aplasia (HP:0100783)1.68167383
82Calcaneovalgus deformity (HP:0001848)1.67212484
83Abnormality of cells of the erythroid lineage (HP:0012130)1.66291031
84Broad finger (HP:0001500)1.64313478
85Renal agenesis (HP:0000104)1.64286866
86Ependymoma (HP:0002888)1.63268574
87Myokymia (HP:0002411)1.63184217
88Abnormality of the aortic arch (HP:0012303)1.63165869
89Omphalocele (HP:0001539)1.62735592
90Tracheal stenosis (HP:0002777)1.62692837
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.62314137
92Patellar aplasia (HP:0006443)1.59760649
93Abnormality of the calcaneus (HP:0008364)1.59751278
94Absent hair (HP:0002298)1.57731386
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.57002556
96Abnormality of abdominal situs (HP:0011620)1.56860786
97Abdominal situs inversus (HP:0003363)1.56860786
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.56715436
99Patent foramen ovale (HP:0001655)1.56230642
100Abnormality of the lacrimal duct (HP:0011481)1.55573629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.32255094
2BUB13.67070626
3VRK23.27127388
4TTK3.16511818
5SRPK12.82895310
6SMG12.71617834
7CAMK1D2.38861575
8MAP3K102.33989489
9CAMK1G2.20888888
10EEF2K2.14259479
11TSSK62.13253385
12MKNK22.12278655
13MKNK12.07186272
14TAF12.05293092
15PLK32.00244064
16PLK41.71866306
17WEE11.71710226
18CHEK21.63850228
19DYRK21.57892005
20CDK121.57790288
21ZAK1.57149898
22TNIK1.55052213
23PLK11.48440579
24PBK1.40550278
25ATR1.33317885
26CDK191.29784398
27CDK71.20961853
28ALK1.20375826
29VRK11.20275016
30NEK11.19517933
31BRAF1.19041429
32BRSK11.18340027
33PNCK1.13554212
34NEK21.09738309
35STK161.08760600
36LATS21.05084555
37CHEK11.04344103
38AURKA1.02643903
39TYRO30.98974132
40MAP3K90.98458325
41NME10.95865765
42NTRK10.94139902
43AURKB0.92716900
44CSNK1G10.90835230
45FGFR20.88078133
46MAP3K80.87651977
47BRD40.87337553
48DYRK30.86687038
49BRSK20.85118199
50PRKD30.83737663
51RPS6KA40.82719450
52ATM0.80233032
53CASK0.79244882
54CSNK1G30.78141950
55STK40.77926025
56CDK20.75069514
57CDK10.74124995
58CSNK1G20.72249857
59STK30.70506643
60CDK11A0.70478488
61CDK150.69495399
62FGFR10.69080138
63UHMK10.69046980
64ARAF0.68343982
65CSNK1E0.68183784
66TRIB30.67525863
67CDK180.66741922
68PASK0.66081607
69WNK30.65809570
70MTOR0.65164878
71KDR0.64618531
72PRKDC0.63893219
73NME20.63672504
74CSNK1A1L0.63421425
75CDK40.62855782
76EIF2AK20.60782509
77PAK40.59669085
78CLK10.56655148
79CDK140.54408940
80NUAK10.50161915
81YES10.49292096
82TRIM280.48884576
83PLK20.48641410
84EPHA40.48625667
85PDGFRA0.47099619
86ERBB40.46742302
87CSNK2A20.46677524
88CSNK2A10.44773088
89BCR0.43423550
90LATS10.43070365
91BMX0.42864285
92CDK30.42794785
93GSK3B0.41685124
94DAPK10.40722076
95ICK0.40304230
96STK38L0.40103804
97DMPK0.39569462
98AKT20.38376431
99BCKDK0.38282641
100MINK10.37528922

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.81921914
2Mismatch repair_Homo sapiens_hsa034302.94995699
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68389333
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52447756
5One carbon pool by folate_Homo sapiens_hsa006702.52233626
6Base excision repair_Homo sapiens_hsa034102.41552745
7Spliceosome_Homo sapiens_hsa030402.29167210
8Vitamin B6 metabolism_Homo sapiens_hsa007502.28728355
9Biosynthesis of amino acids_Homo sapiens_hsa012302.27314168
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.26372854
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10778883
12Cell cycle_Homo sapiens_hsa041101.97223733
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92755890
14RNA transport_Homo sapiens_hsa030131.92728053
15Homologous recombination_Homo sapiens_hsa034401.90243850
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89223925
17Ribosome_Homo sapiens_hsa030101.87246927
18Non-homologous end-joining_Homo sapiens_hsa034501.87096205
19RNA polymerase_Homo sapiens_hsa030201.86512675
20Sulfur relay system_Homo sapiens_hsa041221.66555278
21Pyruvate metabolism_Homo sapiens_hsa006201.60170103
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59419913
23Nucleotide excision repair_Homo sapiens_hsa034201.53782797
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52945760
25Steroid biosynthesis_Homo sapiens_hsa001001.52317118
26Selenocompound metabolism_Homo sapiens_hsa004501.49506443
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47077233
28mRNA surveillance pathway_Homo sapiens_hsa030151.44997551
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42732957
30Basal cell carcinoma_Homo sapiens_hsa052171.38137993
31Pyrimidine metabolism_Homo sapiens_hsa002401.37207486
32Carbon metabolism_Homo sapiens_hsa012001.35179700
33Fanconi anemia pathway_Homo sapiens_hsa034601.34539685
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.28455386
35Proteasome_Homo sapiens_hsa030501.27754711
36Lysine degradation_Homo sapiens_hsa003101.20879471
37RNA degradation_Homo sapiens_hsa030181.16977196
38Arginine and proline metabolism_Homo sapiens_hsa003301.16634234
39Basal transcription factors_Homo sapiens_hsa030221.12850129
40Folate biosynthesis_Homo sapiens_hsa007901.05406088
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05203311
42Hippo signaling pathway_Homo sapiens_hsa043901.02636805
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97150086
44Arginine biosynthesis_Homo sapiens_hsa002200.96841896
45Hedgehog signaling pathway_Homo sapiens_hsa043400.95634761
46Propanoate metabolism_Homo sapiens_hsa006400.94961104
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90315242
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90256555
49Wnt signaling pathway_Homo sapiens_hsa043100.88230867
50Purine metabolism_Homo sapiens_hsa002300.86075283
51Oocyte meiosis_Homo sapiens_hsa041140.80699042
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78109046
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77954916
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77420636
55Adherens junction_Homo sapiens_hsa045200.74759547
56Fatty acid elongation_Homo sapiens_hsa000620.73490008
57Thyroid cancer_Homo sapiens_hsa052160.72088943
58Huntingtons disease_Homo sapiens_hsa050160.71668249
59Tight junction_Homo sapiens_hsa045300.71341420
60Fatty acid metabolism_Homo sapiens_hsa012120.69248076
61Vitamin digestion and absorption_Homo sapiens_hsa049770.68525338
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.66162157
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63445655
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61687880
65Fatty acid biosynthesis_Homo sapiens_hsa000610.60890655
66Parkinsons disease_Homo sapiens_hsa050120.60072604
67Pentose phosphate pathway_Homo sapiens_hsa000300.59917095
68p53 signaling pathway_Homo sapiens_hsa041150.58318227
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57281920
70MicroRNAs in cancer_Homo sapiens_hsa052060.54931296
71Galactose metabolism_Homo sapiens_hsa000520.54670278
72Metabolic pathways_Homo sapiens_hsa011000.54098285
73Retinol metabolism_Homo sapiens_hsa008300.52402378
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49363871
75Caffeine metabolism_Homo sapiens_hsa002320.47420672
76Fatty acid degradation_Homo sapiens_hsa000710.47049080
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.45189658
78Oxidative phosphorylation_Homo sapiens_hsa001900.44931083
79Notch signaling pathway_Homo sapiens_hsa043300.44410203
80beta-Alanine metabolism_Homo sapiens_hsa004100.42808145
81TGF-beta signaling pathway_Homo sapiens_hsa043500.42671679
82Melanogenesis_Homo sapiens_hsa049160.38239109
83Nicotine addiction_Homo sapiens_hsa050330.36271963
84Colorectal cancer_Homo sapiens_hsa052100.34042773
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33772854
86Protein export_Homo sapiens_hsa030600.33490001
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.32767929
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32409094
89Glucagon signaling pathway_Homo sapiens_hsa049220.32284147
90Bladder cancer_Homo sapiens_hsa052190.31003136
91Prostate cancer_Homo sapiens_hsa052150.30693680
92Melanoma_Homo sapiens_hsa052180.30241752
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28562880
94Axon guidance_Homo sapiens_hsa043600.27639501
95N-Glycan biosynthesis_Homo sapiens_hsa005100.27577867
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27112016
97Alcoholism_Homo sapiens_hsa050340.25647867
98Alzheimers disease_Homo sapiens_hsa050100.23599882
99Phenylalanine metabolism_Homo sapiens_hsa003600.23575013
100AMPK signaling pathway_Homo sapiens_hsa041520.23507300

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