CBWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.85098324
2nucleobase biosynthetic process (GO:0046112)5.69698526
3maturation of SSU-rRNA (GO:0030490)4.60364828
4water-soluble vitamin biosynthetic process (GO:0042364)4.42078397
5ribosome assembly (GO:0042255)4.40752937
6ribosome biogenesis (GO:0042254)4.34594676
7mitotic metaphase plate congression (GO:0007080)4.32261759
8DNA deamination (GO:0045006)4.32149098
9DNA replication checkpoint (GO:0000076)4.24020959
10termination of RNA polymerase III transcription (GO:0006386)4.23680028
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.23680028
12DNA replication initiation (GO:0006270)4.22491291
13ribosomal large subunit biogenesis (GO:0042273)4.11253437
14ribonucleoprotein complex biogenesis (GO:0022613)4.03712012
15replication fork processing (GO:0031297)4.02003460
16transcription elongation from RNA polymerase I promoter (GO:0006362)4.01545516
17respiratory chain complex IV assembly (GO:0008535)4.00871909
18termination of RNA polymerase I transcription (GO:0006363)3.96588625
19metaphase plate congression (GO:0051310)3.94264134
20rRNA modification (GO:0000154)3.90239635
21CENP-A containing nucleosome assembly (GO:0034080)3.89481625
22DNA replication-dependent nucleosome assembly (GO:0006335)3.89144682
23DNA replication-dependent nucleosome organization (GO:0034723)3.89144682
24proteasome assembly (GO:0043248)3.87791138
25protein K6-linked ubiquitination (GO:0085020)3.86824787
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.86591488
27nuclear pore organization (GO:0006999)3.86550454
287-methylguanosine mRNA capping (GO:0006370)3.79584725
29chromatin remodeling at centromere (GO:0031055)3.78849282
30formation of translation preinitiation complex (GO:0001731)3.78216793
31regulation of spindle organization (GO:0090224)3.78139213
32transcription from RNA polymerase I promoter (GO:0006360)3.78053602
33IMP biosynthetic process (GO:0006188)3.73487405
34RNA capping (GO:0036260)3.71371930
357-methylguanosine RNA capping (GO:0009452)3.71371930
36spliceosomal snRNP assembly (GO:0000387)3.70453404
37DNA strand elongation involved in DNA replication (GO:0006271)3.67829751
38transcription initiation from RNA polymerase I promoter (GO:0006361)3.64122048
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62583737
40ribosomal small subunit assembly (GO:0000028)3.61510272
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59764478
42DNA double-strand break processing (GO:0000729)3.58845289
43rRNA processing (GO:0006364)3.58329058
44DNA replication-independent nucleosome organization (GO:0034724)3.58054299
45DNA replication-independent nucleosome assembly (GO:0006336)3.58054299
46protein complex biogenesis (GO:0070271)3.57329008
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.57301792
48cytochrome complex assembly (GO:0017004)3.53939616
49histone exchange (GO:0043486)3.53928431
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.51789433
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.51082169
52NADH dehydrogenase complex assembly (GO:0010257)3.51082169
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51082169
54telomere maintenance via semi-conservative replication (GO:0032201)3.50600124
55DNA strand elongation (GO:0022616)3.49477380
56rRNA metabolic process (GO:0016072)3.49458500
57meiotic chromosome segregation (GO:0045132)3.47553402
58protein localization to kinetochore (GO:0034501)3.46480120
59double-strand break repair via homologous recombination (GO:0000724)3.45216682
60recombinational repair (GO:0000725)3.42813262
61mitochondrial respiratory chain complex assembly (GO:0033108)3.41217995
62ribosomal small subunit biogenesis (GO:0042274)3.39216439
63rRNA methylation (GO:0031167)3.38764740
64IMP metabolic process (GO:0046040)3.38492575
65mitotic nuclear envelope disassembly (GO:0007077)3.37189722
66kinetochore organization (GO:0051383)3.36164503
67prenylation (GO:0097354)3.35899113
68protein prenylation (GO:0018342)3.35899113
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30619520
70isotype switching (GO:0045190)3.30619520
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30619520
72nuclear pore complex assembly (GO:0051292)3.29683602
73establishment of chromosome localization (GO:0051303)3.28764328
74attachment of spindle microtubules to kinetochore (GO:0008608)3.28763806
75pseudouridine synthesis (GO:0001522)3.24251324
76telomere maintenance via recombination (GO:0000722)3.23817599
77cellular component biogenesis (GO:0044085)3.23657283
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22725180
79transcription-coupled nucleotide-excision repair (GO:0006283)3.21422460
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19923728
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19201335
82spliceosomal complex assembly (GO:0000245)3.17287648
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15610623
84GMP metabolic process (GO:0046037)3.15528960
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15265430
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14640101
87signal peptide processing (GO:0006465)3.13732460
88nuclear envelope disassembly (GO:0051081)3.13648026
89membrane disassembly (GO:0030397)3.13648026
90translational termination (GO:0006415)3.12222258
91kinetochore assembly (GO:0051382)3.12180817
92maturation of 5.8S rRNA (GO:0000460)3.10858866
93mitotic recombination (GO:0006312)3.09362319
94protein K11-linked deubiquitination (GO:0035871)3.08775466
95establishment of integrated proviral latency (GO:0075713)3.08294270
96DNA-templated transcription, elongation (GO:0006354)3.07892873
97response to pheromone (GO:0019236)3.07299837
98tryptophan catabolic process (GO:0006569)3.07139147
99indole-containing compound catabolic process (GO:0042436)3.07139147
100indolalkylamine catabolic process (GO:0046218)3.07139147
101translational initiation (GO:0006413)3.05506732
102viral transcription (GO:0019083)3.04106626
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03790009
104cell cycle G1/S phase transition (GO:0044843)3.02340692
105G1/S transition of mitotic cell cycle (GO:0000082)3.02340692
106indolalkylamine metabolic process (GO:0006586)3.00847658
107regulation of mitochondrial translation (GO:0070129)2.99996091
108regulation of mitotic spindle checkpoint (GO:1903504)2.99720283
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99720283
110protein localization to chromosome, centromeric region (GO:0071459)2.98302139
111transcription elongation from RNA polymerase II promoter (GO:0006368)2.97865919
112DNA-templated transcription, termination (GO:0006353)2.96815158
113L-fucose catabolic process (GO:0042355)2.96604151
114fucose catabolic process (GO:0019317)2.96604151
115L-fucose metabolic process (GO:0042354)2.96604151
116peptidyl-histidine modification (GO:0018202)2.95144431
117viral mRNA export from host cell nucleus (GO:0046784)2.93748558
118regulation of centrosome cycle (GO:0046605)2.92412203
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92274281
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92203814
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.92203814
122regulation of mitotic spindle organization (GO:0060236)2.92113073
123somatic diversification of immunoglobulins (GO:0016445)2.91795294
124regulation of DNA endoreduplication (GO:0032875)2.91701261
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.91517107
126telomere maintenance via telomere lengthening (GO:0010833)2.90840929
127resolution of meiotic recombination intermediates (GO:0000712)2.88328385
128regulation of translation in response to stress (GO:0043555)2.85791456
129RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85377205
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85377205
131translation (GO:0006412)2.85157117
132kynurenine metabolic process (GO:0070189)2.84860944
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.84634730
134ncRNA metabolic process (GO:0034660)2.84175870
135spindle checkpoint (GO:0031577)2.84011053
136negative regulation of ligase activity (GO:0051352)2.83104129
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83104129
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81503468
139translational elongation (GO:0006414)2.81028659
140guanosine-containing compound biosynthetic process (GO:1901070)2.80849821
141replicative senescence (GO:0090399)2.80504273
142blastocyst development (GO:0001824)2.80427184
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79558608
144somatic recombination of immunoglobulin gene segments (GO:0016447)2.79194754
145preassembly of GPI anchor in ER membrane (GO:0016254)2.77493125
146regulation of hexokinase activity (GO:1903299)2.75488845
147regulation of glucokinase activity (GO:0033131)2.75488845
148lactate metabolic process (GO:0006089)2.72453404
149DNA catabolic process, exonucleolytic (GO:0000738)2.70560981
150histone mRNA metabolic process (GO:0008334)2.69235300
151behavioral response to nicotine (GO:0035095)2.66914726
152tryptophan metabolic process (GO:0006568)2.66131225
153mitochondrial RNA metabolic process (GO:0000959)2.65456350
154synapsis (GO:0007129)2.64654132
155regulation of mesoderm development (GO:2000380)2.63753185
156L-methionine biosynthetic process (GO:0071265)2.63166523
157amino acid salvage (GO:0043102)2.63166523
158L-methionine salvage (GO:0071267)2.63166523
159mannosylation (GO:0097502)2.60910384
160protein-cofactor linkage (GO:0018065)2.59713477
161sulfation (GO:0051923)2.58870974
162double-strand break repair (GO:0006302)2.56867437
163tRNA processing (GO:0008033)2.56317235
164centriole replication (GO:0007099)2.55578206
165reciprocal DNA recombination (GO:0035825)2.53164688
166reciprocal meiotic recombination (GO:0007131)2.53164688
167positive regulation of histone H3-K4 methylation (GO:0051571)2.51379766
168kidney morphogenesis (GO:0060993)2.51301110
169cullin deneddylation (GO:0010388)2.51133091
170single strand break repair (GO:0000012)2.49305054
171cellular ketone body metabolic process (GO:0046950)2.48799192
172histone mRNA catabolic process (GO:0071044)2.48232605
173platelet dense granule organization (GO:0060155)2.47214047
174keratinocyte development (GO:0003334)2.46749220
175postreplication repair (GO:0006301)2.45890072
176detection of light stimulus involved in sensory perception (GO:0050962)2.45823611
177detection of light stimulus involved in visual perception (GO:0050908)2.45823611
178axoneme assembly (GO:0035082)2.45026715
179protein neddylation (GO:0045116)2.44932883
180pteridine-containing compound biosynthetic process (GO:0042559)2.44301351
181mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44279499
182rRNA catabolic process (GO:0016075)2.44131636
183photoreceptor cell maintenance (GO:0045494)2.43973686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.22225449
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.39691105
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00207949
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.69871876
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.67181765
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48206282
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46686770
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23160262
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19322285
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.16819274
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.12891105
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06074390
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.94628069
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93405840
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89188963
16ZNF274_21170338_ChIP-Seq_K562_Hela2.81863065
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81134151
18VDR_22108803_ChIP-Seq_LS180_Human2.79489840
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78542833
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68525715
21VDR_23849224_ChIP-Seq_CD4+_Human2.63731585
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62322110
23FUS_26573619_Chip-Seq_HEK293_Human2.55389538
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55052720
25EWS_26573619_Chip-Seq_HEK293_Human2.51280738
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43882742
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43782348
28ELK1_19687146_ChIP-ChIP_HELA_Human2.38852233
29IGF1R_20145208_ChIP-Seq_DFB_Human2.36241681
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30735925
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29755130
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29639379
33GBX2_23144817_ChIP-Seq_PC3_Human2.28338264
34XRN2_22483619_ChIP-Seq_HELA_Human2.25516273
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21372000
36DCP1A_22483619_ChIP-Seq_HELA_Human2.19079301
37TAF15_26573619_Chip-Seq_HEK293_Human2.17693924
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15581022
39AR_21909140_ChIP-Seq_LNCAP_Human2.11896130
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07705189
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06868189
42FOXP3_21729870_ChIP-Seq_TREG_Human2.02083176
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01346427
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01110276
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99964324
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98971572
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96946852
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91261642
49GABP_19822575_ChIP-Seq_HepG2_Human1.90980839
50P300_19829295_ChIP-Seq_ESCs_Human1.89431730
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87174157
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86579142
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84735214
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83915949
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83433036
56TTF2_22483619_ChIP-Seq_HELA_Human1.82017335
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.80656498
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79875305
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73414669
60ER_23166858_ChIP-Seq_MCF-7_Human1.72466712
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72355397
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71736971
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71563130
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.69008633
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62142355
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59670243
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59545427
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.56981135
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50332326
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48158485
71* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45870029
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45023263
73IRF1_19129219_ChIP-ChIP_H3396_Human1.43460503
74CBP_20019798_ChIP-Seq_JUKART_Human1.42681750
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42681750
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42076424
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42006309
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41709330
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41480458
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.41358272
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.38662036
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35408200
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33597510
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.33151460
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32406074
86* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31887473
87STAT3_23295773_ChIP-Seq_U87_Human1.31079845
88KDM5A_27292631_Chip-Seq_BREAST_Human1.29742377
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.28770109
90TP53_22573176_ChIP-Seq_HFKS_Human1.28259867
91BCAT_22108803_ChIP-Seq_LS180_Human1.28148548
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28102901
93SMAD4_21799915_ChIP-Seq_A2780_Human1.27991155
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27493645
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25677532
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24708361
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.24355811
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23543734
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23399106
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.23196865
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22661380
102NANOG_19829295_ChIP-Seq_ESCs_Human1.22187640
103SOX2_19829295_ChIP-Seq_ESCs_Human1.22187640
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22142716
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19568547
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.18794678
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18674092
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18213824
109CDX2_22108803_ChIP-Seq_LS180_Human1.17356364
110TCF4_23295773_ChIP-Seq_U87_Human1.17265755
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17246517
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17132966
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17081067
114P53_22387025_ChIP-Seq_ESCs_Mouse1.16450530
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15364660
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.15364660
117TCF4_22108803_ChIP-Seq_LS180_Human1.14291003
118AR_25329375_ChIP-Seq_VCAP_Human1.12197803
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.10906064
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.10452733
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09633742
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09507384
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08844441
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08795878
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08625009
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.07346218
127P300_18555785_Chip-Seq_ESCs_Mouse1.07188993
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06755757
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06049943
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05252536
131* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04943307
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.04168697
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03021190
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.03002500
135TFEB_21752829_ChIP-Seq_HELA_Human1.02334833
136SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02072991
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01943281
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00409862
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99788835
140RUNX2_22187159_ChIP-Seq_PCA_Human0.99708166
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99613167
142AR_20517297_ChIP-Seq_VCAP_Human0.99301047
143CIITA_25753668_ChIP-Seq_RAJI_Human0.98937732
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.97408031
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95983031
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95132384
147MYC_18940864_ChIP-ChIP_HL60_Human0.94658638
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94456830
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93717725
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92658546
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90162749
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89468255
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87703792
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87533721
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82408607
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82408607
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82408607
158* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80520798
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80318000
160TP63_19390658_ChIP-ChIP_HaCaT_Human0.80078579
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78631073
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77645195
163EGR1_19374776_ChIP-ChIP_THP-1_Human0.75910340
164SPI1_23547873_ChIP-Seq_NB4_Human0.75039514
165NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74220064
166* NANOG_16153702_ChIP-ChIP_HESCs_Human0.73946993
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.73728993
168* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72452490
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71275367
170CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71000476
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70838587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.26995247
2MP0010094_abnormal_chromosome_stability4.68452925
3MP0004957_abnormal_blastocyst_morpholog4.65821623
4MP0003077_abnormal_cell_cycle4.03506438
5MP0008057_abnormal_DNA_replication3.97486329
6MP0003111_abnormal_nucleus_morphology3.82803285
7MP0008058_abnormal_DNA_repair3.81642743
8MP0008877_abnormal_DNA_methylation3.44533181
9MP0003195_calcinosis3.17090086
10MP0003786_premature_aging3.02627963
11MP0003123_paternal_imprinting3.00011292
12MP0008007_abnormal_cellular_replicative2.95280975
13MP0008932_abnormal_embryonic_tissue2.79004509
14MP0001730_embryonic_growth_arrest2.47125350
15MP0002837_dystrophic_cardiac_calcinosis2.45739543
16MP0000569_abnormal_digit_pigmentation2.45389691
17MP0003718_maternal_effect2.42027759
18MP0002102_abnormal_ear_morphology2.40426762
19MP0003787_abnormal_imprinting2.27723810
20MP0006072_abnormal_retinal_apoptosis2.25816957
21MP0005551_abnormal_eye_electrophysiolog2.17826965
22MP0000350_abnormal_cell_proliferation2.14269803
23MP0003646_muscle_fatigue2.13547567
24MP0002876_abnormal_thyroid_physiology2.06151370
25MP0005379_endocrine/exocrine_gland_phen2.01586368
26MP0002396_abnormal_hematopoietic_system1.96641959
27MP0010307_abnormal_tumor_latency1.84543637
28MP0002210_abnormal_sex_determination1.83792694
29MP0005646_abnormal_pituitary_gland1.81738325
30MP0003806_abnormal_nucleotide_metabolis1.75345001
31MP0001929_abnormal_gametogenesis1.72496936
32MP0008872_abnormal_physiological_respon1.65507257
33MP0005253_abnormal_eye_physiology1.65233472
34MP0001145_abnormal_male_reproductive1.60250662
35MP0000427_abnormal_hair_cycle1.60247044
36MP0005645_abnormal_hypothalamus_physiol1.59841342
37MP0001697_abnormal_embryo_size1.57715095
38MP0005380_embryogenesis_phenotype1.55917539
39MP0001672_abnormal_embryogenesis/_devel1.55917539
40MP0002080_prenatal_lethality1.50372794
41MP0008995_early_reproductive_senescence1.50203777
42MP0003567_abnormal_fetal_cardiomyocyte1.49415870
43MP0001485_abnormal_pinna_reflex1.46715987
44MP0000383_abnormal_hair_follicle1.45039658
45MP0009046_muscle_twitch1.43323651
46MP0003984_embryonic_growth_retardation1.36119368
47MP0000653_abnormal_sex_gland1.35664678
48MP0002009_preneoplasia1.35653032
49MP0003315_abnormal_perineum_morphology1.34940658
50MP0009333_abnormal_splenocyte_physiolog1.34843489
51MP0001984_abnormal_olfaction1.34758924
52MP0000313_abnormal_cell_death1.31303268
53MP0002088_abnormal_embryonic_growth/wei1.30887985
54MP0002085_abnormal_embryonic_tissue1.30704725
55MP0000631_abnormal_neuroendocrine_gland1.29466002
56MP0004043_abnormal_pH_regulation1.29042894
57MP0006036_abnormal_mitochondrial_physio1.27251002
58MP0004197_abnormal_fetal_growth/weight/1.26704190
59MP0003136_yellow_coat_color1.26184692
60MP0003121_genomic_imprinting1.25947401
61MP0002086_abnormal_extraembryonic_tissu1.24798021
62MP0001968_abnormal_touch/_nociception1.24541471
63MP0004147_increased_porphyrin_level1.24224541
64MP0003941_abnormal_skin_development1.23599108
65MP0003186_abnormal_redox_activity1.23400755
66MP0010678_abnormal_skin_adnexa1.22288001
67MP0002084_abnormal_developmental_patter1.22143574
68MP0008875_abnormal_xenobiotic_pharmacok1.19694399
69MP0001501_abnormal_sleep_pattern1.18626982
70MP0004142_abnormal_muscle_tone1.18065044
71MP0005410_abnormal_fertilization1.17631727
72MP0000358_abnormal_cell_content/1.17153410
73MP0006292_abnormal_olfactory_placode1.17098050
74MP0002163_abnormal_gland_morphology1.16484350
75MP0002254_reproductive_system_inflammat1.16295616
76MP0002736_abnormal_nociception_after1.11975964
77MP0005075_abnormal_melanosome_morpholog1.11124675
78MP0001293_anophthalmia1.09755230
79MP0003698_abnormal_male_reproductive1.09660980
80MP0002160_abnormal_reproductive_system1.09094816
81MP0004133_heterotaxia1.08799714
82MP0005332_abnormal_amino_acid1.08677837
83MP0001661_extended_life_span1.08651161
84MP0006035_abnormal_mitochondrial_morpho1.08204595
85MP0003252_abnormal_bile_duct1.07862117
86MP0000516_abnormal_urinary_system1.07695642
87MP0005367_renal/urinary_system_phenotyp1.07695642
88MP0005174_abnormal_tail_pigmentation1.06811458
89MP0010386_abnormal_urinary_bladder1.02981103
90MP0002019_abnormal_tumor_incidence1.01865090
91MP0003937_abnormal_limbs/digits/tail_de1.01378376
92MP0005389_reproductive_system_phenotype1.01047257
93MP0005084_abnormal_gallbladder_morpholo0.99716349
94MP0010352_gastrointestinal_tract_polyps0.99319083
95MP0005220_abnormal_exocrine_pancreas0.98237110
96MP0002693_abnormal_pancreas_physiology0.96809820
97MP0002928_abnormal_bile_duct0.96380929
98MP0005670_abnormal_white_adipose0.96189718
99MP0000647_abnormal_sebaceous_gland0.94994590
100MP0009745_abnormal_behavioral_response0.91705629
101MP0004215_abnormal_myocardial_fiber0.89404007
102MP0002090_abnormal_vision0.88602915
103MP0004808_abnormal_hematopoietic_stem0.88273690
104MP0002282_abnormal_trachea_morphology0.87415589
105MP0005384_cellular_phenotype0.87090900
106MP0005171_absent_coat_pigmentation0.85884699
107MP0002138_abnormal_hepatobiliary_system0.84828651
108MP0005310_abnormal_salivary_gland0.83894498
109MP0006054_spinal_hemorrhage0.82346131
110MP0002272_abnormal_nervous_system0.82286770
111MP0005195_abnormal_posterior_eye0.82277367
112MP0001986_abnormal_taste_sensitivity0.82216307
113MP0001119_abnormal_female_reproductive0.82200005
114MP0001542_abnormal_bone_strength0.80621050
115MP0003221_abnormal_cardiomyocyte_apopto0.79788852
116MP0000490_abnormal_crypts_of0.77952635
117MP0009379_abnormal_foot_pigmentation0.77729533
118MP0005408_hypopigmentation0.75676636
119MP0005621_abnormal_cell_physiology0.74209410
120MP0002161_abnormal_fertility/fecundity0.74013619
121MP0000372_irregular_coat_pigmentation0.73865133
122MP0000537_abnormal_urethra_morphology0.72601672
123MP0003890_abnormal_embryonic-extraembry0.72554707
124MP0005085_abnormal_gallbladder_physiolo0.72387169
125MP0008789_abnormal_olfactory_epithelium0.71190578
126MP0002938_white_spotting0.71021312
127MP0002229_neurodegeneration0.70244798
128MP0004084_abnormal_cardiac_muscle0.70226525
129MP0005395_other_phenotype0.70192773
130MP0001944_abnormal_pancreas_morphology0.68744829
131MP0006276_abnormal_autonomic_nervous0.68618069
132MP0003011_delayed_dark_adaptation0.67639526
133MP0001919_abnormal_reproductive_system0.67338086
134MP0009697_abnormal_copulation0.65688601
135MP0002132_abnormal_respiratory_system0.65557831
136MP0005397_hematopoietic_system_phenotyp0.63697512
137MP0001545_abnormal_hematopoietic_system0.63697512
138MP0001764_abnormal_homeostasis0.62599160
139MP0002127_abnormal_cardiovascular_syste0.61911938
140MP0001286_abnormal_eye_development0.61378608
141MP0000749_muscle_degeneration0.61019649
142MP0003950_abnormal_plasma_membrane0.60465387
143MP0000750_abnormal_muscle_regeneration0.59138896
144MP0005266_abnormal_metabolism0.59050294
145MP0001727_abnormal_embryo_implantation0.58256140
146MP0001188_hyperpigmentation0.57871122
147MP0001529_abnormal_vocalization0.57499241
148MP0004134_abnormal_chest_morphology0.57455209
149MP0005076_abnormal_cell_differentiation0.57412304
150MP0009703_decreased_birth_body0.55832349
151MP0002095_abnormal_skin_pigmentation0.55736030
152MP0001853_heart_inflammation0.55024782
153MP0000703_abnormal_thymus_morphology0.54687207
154MP0000428_abnormal_craniofacial_morphol0.53276660
155MP0002111_abnormal_tail_morphology0.53173566
156MP0002751_abnormal_autonomic_nervous0.53018601
157MP0005501_abnormal_skin_physiology0.52495901

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.89408892
2Breast hypoplasia (HP:0003187)4.62478748
3Abnormality of cells of the erythroid lineage (HP:0012130)4.23057680
4Abnormal number of erythroid precursors (HP:0012131)3.96855857
5Pancreatic cysts (HP:0001737)3.84795196
6Irregular epiphyses (HP:0010582)3.83416444
7Carpal bone hypoplasia (HP:0001498)3.82023909
8Cerebral hypomyelination (HP:0006808)3.76617242
9Degeneration of anterior horn cells (HP:0002398)3.61871272
10Abnormality of the anterior horn cell (HP:0006802)3.61871272
11Colon cancer (HP:0003003)3.28939834
12Molar tooth sign on MRI (HP:0002419)3.26998427
13Abnormality of midbrain morphology (HP:0002418)3.26998427
14True hermaphroditism (HP:0010459)3.21601386
15Rough bone trabeculation (HP:0100670)3.07923950
16Impulsivity (HP:0100710)2.99541276
17Nephronophthisis (HP:0000090)2.97970902
18Methylmalonic acidemia (HP:0002912)2.91909586
19Reticulocytopenia (HP:0001896)2.86906392
20Agnosia (HP:0010524)2.84726879
21Glossoptosis (HP:0000162)2.83735722
22Gaze-evoked nystagmus (HP:0000640)2.83544335
23Abnormality of the renal cortex (HP:0011035)2.80931166
24Patellar aplasia (HP:0006443)2.79051865
25Oral leukoplakia (HP:0002745)2.78490405
26Aplastic anemia (HP:0001915)2.74197646
27Congenital stationary night blindness (HP:0007642)2.73589078
28Abnormality of the renal medulla (HP:0100957)2.71241906
29Medial flaring of the eyebrow (HP:0010747)2.69427443
30Increased CSF lactate (HP:0002490)2.68520889
31Abolished electroretinogram (ERG) (HP:0000550)2.68311504
32CNS hypomyelination (HP:0003429)2.65798440
33Progressive macrocephaly (HP:0004481)2.61694809
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60875950
35Abnormality of chromosome stability (HP:0003220)2.60245262
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.59572124
37Absent epiphyses (HP:0010577)2.59572124
38Aplasia/Hypoplasia of the patella (HP:0006498)2.57936914
39Chronic hepatic failure (HP:0100626)2.53730342
40Macrocytic anemia (HP:0001972)2.52531306
41Selective tooth agenesis (HP:0001592)2.49003540
42Abnormality of the preputium (HP:0100587)2.48438835
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46971734
44Acute encephalopathy (HP:0006846)2.45511948
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45333355
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45333355
47Mitochondrial inheritance (HP:0001427)2.44958637
48Renal cortical cysts (HP:0000803)2.44339293
49Methylmalonic aciduria (HP:0012120)2.43491890
50Premature graying of hair (HP:0002216)2.41489336
51Progressive muscle weakness (HP:0003323)2.41349841
52Chromsome breakage (HP:0040012)2.40943670
53Abnormal spermatogenesis (HP:0008669)2.40181427
54Abnormal trabecular bone morphology (HP:0100671)2.38092880
5511 pairs of ribs (HP:0000878)2.37715338
56Large for gestational age (HP:0001520)2.37560436
57Meckel diverticulum (HP:0002245)2.36287326
58Attenuation of retinal blood vessels (HP:0007843)2.34385830
59Intestinal atresia (HP:0011100)2.33218990
60Volvulus (HP:0002580)2.30166860
61Abnormality of the labia minora (HP:0012880)2.28780944
62Abnormality of the renal collecting system (HP:0004742)2.25903334
63Abnormal mitochondria in muscle tissue (HP:0008316)2.24345861
64Supernumerary spleens (HP:0009799)2.23814233
65Duodenal stenosis (HP:0100867)2.19107909
66Small intestinal stenosis (HP:0012848)2.19107909
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.18847425
68Furrowed tongue (HP:0000221)2.18499283
69Absent radius (HP:0003974)2.17475020
70Hypothermia (HP:0002045)2.17453283
71Pallor (HP:0000980)2.15948446
72Abnormal lung lobation (HP:0002101)2.15556738
73Secondary amenorrhea (HP:0000869)2.15541331
74Increased serum pyruvate (HP:0003542)2.15089366
75Abnormality of glycolysis (HP:0004366)2.15089366
76Bone marrow hypocellularity (HP:0005528)2.15067601
773-Methylglutaconic aciduria (HP:0003535)2.14696317
78Abnormality of the ileum (HP:0001549)2.14132096
79Duplicated collecting system (HP:0000081)2.13607707
80Pendular nystagmus (HP:0012043)2.12842077
81Trismus (HP:0000211)2.12739721
82Abnormality of the umbilical cord (HP:0010881)2.12152088
83Lipid accumulation in hepatocytes (HP:0006561)2.11560271
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10477964
85Abnormality of alanine metabolism (HP:0010916)2.10477964
86Hyperalaninemia (HP:0003348)2.10477964
87Flat capital femoral epiphysis (HP:0003370)2.10404672
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09352012
89Ependymoma (HP:0002888)2.08653319
90Increased hepatocellular lipid droplets (HP:0006565)2.08355711
91Abnormality of vitamin B metabolism (HP:0004340)2.06623219
92Abnormality of the pons (HP:0007361)2.06337607
93Congenital primary aphakia (HP:0007707)2.05437338
94Cystic liver disease (HP:0006706)2.05203597
95Hepatocellular necrosis (HP:0001404)2.04591064
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.03099936
97Neoplasm of the pancreas (HP:0002894)2.02706676
98Hepatic necrosis (HP:0002605)2.02177776
99Genital tract atresia (HP:0001827)2.01926773
100Small epiphyses (HP:0010585)2.01612416
101Rhabdomyosarcoma (HP:0002859)2.01396733
102Type II lissencephaly (HP:0007260)2.01372999
103Type 2 muscle fiber atrophy (HP:0003554)2.01123260
104Bile duct proliferation (HP:0001408)2.01023545
105Abnormal biliary tract physiology (HP:0012439)2.01023545
106Facial cleft (HP:0002006)1.99546666
107Chorioretinal atrophy (HP:0000533)1.99385474
108Multiple enchondromatosis (HP:0005701)1.99032428
109Sparse eyelashes (HP:0000653)1.98440228
110Microvesicular hepatic steatosis (HP:0001414)1.97272458
111Thyroiditis (HP:0100646)1.95522389
112Pancreatic islet-cell hyperplasia (HP:0004510)1.95196381
113Progressive inability to walk (HP:0002505)1.95168353
114Absent forearm bone (HP:0003953)1.93938769
115Aplasia involving forearm bones (HP:0009822)1.93938769
116Hyperglycinemia (HP:0002154)1.93429240
117Pancreatic fibrosis (HP:0100732)1.93365169
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92864922
119Abnormal protein N-linked glycosylation (HP:0012347)1.92864922
120Abnormal protein glycosylation (HP:0012346)1.92864922
121Abnormal glycosylation (HP:0012345)1.92864922
122Gait imbalance (HP:0002141)1.92486396
123Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92459123
124Abnormality of macular pigmentation (HP:0008002)1.91805937
125Septate vagina (HP:0001153)1.91759161
126Sloping forehead (HP:0000340)1.91587829
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.91105829
128Absent/shortened dynein arms (HP:0200106)1.91105829
129Pancytopenia (HP:0001876)1.91101922
130Stenosis of the external auditory canal (HP:0000402)1.90262369
131Abnormality of serum amino acid levels (HP:0003112)1.89671768
132Postnatal microcephaly (HP:0005484)1.89608866
133Horseshoe kidney (HP:0000085)1.89200147
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.89035272
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88919536
136Clubbing of toes (HP:0100760)1.88867288
137Hypoplasia of the pons (HP:0012110)1.88862811
138Myelodysplasia (HP:0002863)1.88653826
139Neoplasm of the adrenal cortex (HP:0100641)1.88428600
140Broad-based gait (HP:0002136)1.87715046
141Delayed epiphyseal ossification (HP:0002663)1.86925579
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85888305
143Nephrogenic diabetes insipidus (HP:0009806)1.85470639
144Small hand (HP:0200055)1.85393371
145Tubular atrophy (HP:0000092)1.85296919
146Stomach cancer (HP:0012126)1.84995022
147Ureteral duplication (HP:0000073)1.84433818
148Rectal fistula (HP:0100590)1.83947036
149Rectovaginal fistula (HP:0000143)1.83947036
150Aplasia/hypoplasia of the humerus (HP:0006507)1.83031386
151Tongue fasciculations (HP:0001308)1.82651811
152Entropion (HP:0000621)1.82391724
153Decreased central vision (HP:0007663)1.81694967
154Cerebral edema (HP:0002181)1.81143413
155Congenital, generalized hypertrichosis (HP:0004540)1.81002704
156Muscle fiber atrophy (HP:0100295)1.80878927
157Acute necrotizing encephalopathy (HP:0006965)1.80517217
158Abnormality of the vitamin B12 metabolism (HP:0004341)1.80301395
159Optic disc pallor (HP:0000543)1.79892163
160Abnormal rod and cone electroretinograms (HP:0008323)1.79841689
161Ketoacidosis (HP:0001993)1.79197403
162Vaginal atresia (HP:0000148)1.79019909
163Sclerocornea (HP:0000647)1.78795043
164Type I transferrin isoform profile (HP:0003642)1.78636350
165Medulloblastoma (HP:0002885)1.78258106
166Stillbirth (HP:0003826)1.78125960
167Breast aplasia (HP:0100783)1.77518556
168Microretrognathia (HP:0000308)1.77057616
169Male pseudohermaphroditism (HP:0000037)1.76921191
170Absent thumb (HP:0009777)1.75658117
171Central scotoma (HP:0000603)1.75547889
172Premature ovarian failure (HP:0008209)1.75363812
173Metaphyseal dysplasia (HP:0100255)1.75328339
174Short tibia (HP:0005736)1.75164797
175Cleft eyelid (HP:0000625)1.74968496
176Increased serum lactate (HP:0002151)1.74840101
177Postaxial foot polydactyly (HP:0001830)1.74593917
178Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74436749
179Abnormality of methionine metabolism (HP:0010901)1.72620212
180Lethargy (HP:0001254)1.69677741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.56219764
2WEE14.39956085
3EIF2AK14.34321178
4BUB14.01276599
5CDC73.31307361
6TSSK63.30326889
7BRSK23.00425435
8EIF2AK32.79595734
9TAF12.55239653
10SRPK12.50184339
11ACVR1B2.47010524
12NME22.35934828
13PLK42.33895396
14GRK12.29791175
15MST42.28648861
16STK162.27520364
17MAP4K22.12443206
18ADRBK22.10249512
19ZAK2.04740391
20PLK31.99179405
21NEK21.91803881
22TTK1.86917605
23PDK31.86099259
24PDK41.86099259
25PLK11.77405780
26TRIM281.66601204
27VRK11.64658888
28MKNK11.59324107
29OXSR11.54510616
30NEK11.52878108
31AURKB1.51523859
32MKNK21.51001868
33CHEK21.50245022
34TNIK1.48855791
35CCNB11.45428278
36BRSK11.44758605
37TAOK31.44331377
38DYRK31.39821323
39EPHA21.38281185
40PDK21.35898709
41ATR1.31714233
42AKT31.29101845
43CDK71.28478558
44TGFBR11.23579370
45ERBB31.21175065
46INSRR1.15339381
47NME11.13675255
48EIF2AK21.12879174
49TLK11.11209111
50AURKA1.10729116
51MAP3K41.10513773
52CHEK11.05681743
53VRK21.01817396
54PNCK1.01188147
55WNK41.00690085
56PASK1.00654079
57PAK30.92018235
58FGFR20.91033603
59PIM20.87886503
60TESK10.86609074
61RPS6KB20.85679793
62CDK80.84155308
63PIM10.83613300
64CSNK1G20.80386664
65CSNK2A20.79564114
66STK38L0.78781381
67BMPR1B0.77696064
68MELK0.76558822
69NLK0.76291313
70MAP3K30.75546467
71CASK0.75055683
72BCR0.74549960
73ATM0.74444677
74PRKCE0.74245196
75RPS6KA40.72934290
76CSNK2A10.72224715
77MAPK130.70013856
78MAP3K80.69577419
79STK100.69244867
80PLK20.67784610
81STK30.67614477
82LIMK10.65141591
83CDK20.64456044
84PBK0.63090812
85TESK20.62804412
86FER0.62296860
87RPS6KA50.59387924
88ADRBK10.58902666
89NEK90.58849511
90CDK10.56665454
91TXK0.54410758
92PRKCI0.53452756
93PRKCG0.53310379
94BCKDK0.51784196
95STK40.50945978
96TRPM70.49525729
97CSNK1G30.48832119
98NEK60.48686772
99PAK40.48587467
100FLT30.48080564
101MAPKAPK30.47240075
102PIK3CA0.44967128
103STK240.43397435
104OBSCN0.42803374
105LATS10.42651363
106PIK3CG0.42055456
107BRD40.41526249
108BMPR20.41251226
109IRAK10.40159793
110CDK40.40103070
111NTRK30.40093678
112MARK30.39360534
113PAK10.38981718
114CSNK1A10.38699277
115MUSK0.36235104
116CDK120.35803889
117LATS20.35699437
118CDK30.34710520
119BRAF0.33195761
120MAP3K120.33155919
121MAP2K70.32997891
122CSNK1D0.32082299
123CSNK1G10.31194027
124MAPKAPK50.29430817
125TIE10.29352843
126DYRK20.28479896
127NUAK10.27804568
128CSNK1E0.27618383
129ALK0.25398981
130WNK30.24921537
131RPS6KB10.22417871
132PINK10.22027699
133MET0.20776155
134TEC0.19997826
135CSNK1A1L0.19598392
136IKBKB0.19417053
137KDR0.17822500
138STK390.17765290

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.47411078
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.25104105
3DNA replication_Homo sapiens_hsa030303.93457124
4Proteasome_Homo sapiens_hsa030503.80077906
5Mismatch repair_Homo sapiens_hsa034303.55833395
6Ribosome_Homo sapiens_hsa030103.43751252
7RNA transport_Homo sapiens_hsa030133.21931575
8Spliceosome_Homo sapiens_hsa030403.06768623
9Nucleotide excision repair_Homo sapiens_hsa034202.84414979
10Pyrimidine metabolism_Homo sapiens_hsa002402.76982315
11Homologous recombination_Homo sapiens_hsa034402.71516211
12Basal transcription factors_Homo sapiens_hsa030222.71255526
13Cell cycle_Homo sapiens_hsa041102.50376463
14Fanconi anemia pathway_Homo sapiens_hsa034602.34229707
15Vitamin B6 metabolism_Homo sapiens_hsa007502.25766843
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23842653
17Non-homologous end-joining_Homo sapiens_hsa034502.21346833
18Base excision repair_Homo sapiens_hsa034102.19132488
19Phototransduction_Homo sapiens_hsa047442.06111326
20Propanoate metabolism_Homo sapiens_hsa006402.06046839
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00645721
22RNA degradation_Homo sapiens_hsa030181.90937650
23Purine metabolism_Homo sapiens_hsa002301.82663224
24Butanoate metabolism_Homo sapiens_hsa006501.75994175
25Protein export_Homo sapiens_hsa030601.74091477
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74010406
27One carbon pool by folate_Homo sapiens_hsa006701.70404234
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.69036270
29Nitrogen metabolism_Homo sapiens_hsa009101.53498607
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46736631
31p53 signaling pathway_Homo sapiens_hsa041151.45211905
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42263977
33Tryptophan metabolism_Homo sapiens_hsa003801.42216441
34mRNA surveillance pathway_Homo sapiens_hsa030151.37121665
35Oxidative phosphorylation_Homo sapiens_hsa001901.33120240
36Caffeine metabolism_Homo sapiens_hsa002321.29206604
37Huntingtons disease_Homo sapiens_hsa050161.23819931
38Parkinsons disease_Homo sapiens_hsa050121.22001796
39Sulfur metabolism_Homo sapiens_hsa009201.21284046
40Epstein-Barr virus infection_Homo sapiens_hsa051691.18441794
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17024724
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15968166
43Systemic lupus erythematosus_Homo sapiens_hsa053221.10972642
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07979939
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02993755
46Peroxisome_Homo sapiens_hsa041461.02210958
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00131117
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00059067
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.99481423
50Oocyte meiosis_Homo sapiens_hsa041140.98155218
51Folate biosynthesis_Homo sapiens_hsa007900.96549725
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95200634
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.95148669
54Retinol metabolism_Homo sapiens_hsa008300.93771954
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92312337
56Chemical carcinogenesis_Homo sapiens_hsa052040.91664426
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90657538
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89135500
59Fatty acid elongation_Homo sapiens_hsa000620.85981621
60Pentose phosphate pathway_Homo sapiens_hsa000300.85279382
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82025068
62Olfactory transduction_Homo sapiens_hsa047400.81066345
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.80957806
64ABC transporters_Homo sapiens_hsa020100.80343869
65Taste transduction_Homo sapiens_hsa047420.80236716
66Regulation of autophagy_Homo sapiens_hsa041400.79279458
67Circadian rhythm_Homo sapiens_hsa047100.78707997
68Antigen processing and presentation_Homo sapiens_hsa046120.76056433
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.70454887
70Selenocompound metabolism_Homo sapiens_hsa004500.70334164
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67660083
72Viral carcinogenesis_Homo sapiens_hsa052030.67204152
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66225123
74Biosynthesis of amino acids_Homo sapiens_hsa012300.65825621
75Sphingolipid metabolism_Homo sapiens_hsa006000.64345445
76Steroid biosynthesis_Homo sapiens_hsa001000.64071133
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62204069
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61633268
79Nicotine addiction_Homo sapiens_hsa050330.60759774
80beta-Alanine metabolism_Homo sapiens_hsa004100.60660394
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60360707
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60292048
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59179939
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58340217
85Alzheimers disease_Homo sapiens_hsa050100.56342750
86Type I diabetes mellitus_Homo sapiens_hsa049400.54660068
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54520081
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53889619
89Herpes simplex infection_Homo sapiens_hsa051680.53702257
90Fatty acid degradation_Homo sapiens_hsa000710.52281654
91Metabolic pathways_Homo sapiens_hsa011000.51114138
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51033380
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50002262
94Fatty acid metabolism_Homo sapiens_hsa012120.48747603
95Cardiac muscle contraction_Homo sapiens_hsa042600.44823208
96Carbon metabolism_Homo sapiens_hsa012000.44656801
97Mineral absorption_Homo sapiens_hsa049780.43766982
98Glutathione metabolism_Homo sapiens_hsa004800.42020031
99Lysine degradation_Homo sapiens_hsa003100.40933554
100TGF-beta signaling pathway_Homo sapiens_hsa043500.38029915
101Allograft rejection_Homo sapiens_hsa053300.36514681
102Serotonergic synapse_Homo sapiens_hsa047260.36286195
103Arachidonic acid metabolism_Homo sapiens_hsa005900.35958486
104HTLV-I infection_Homo sapiens_hsa051660.35517893
105Vitamin digestion and absorption_Homo sapiens_hsa049770.34379158
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33090943
107Legionellosis_Homo sapiens_hsa051340.32899558
108Fatty acid biosynthesis_Homo sapiens_hsa000610.32377877
109Sulfur relay system_Homo sapiens_hsa041220.32313831
110Fat digestion and absorption_Homo sapiens_hsa049750.32270760
111Alcoholism_Homo sapiens_hsa050340.30638251
112Thyroid cancer_Homo sapiens_hsa052160.30310620
113Linoleic acid metabolism_Homo sapiens_hsa005910.28212479
114Small cell lung cancer_Homo sapiens_hsa052220.25286284
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25161706
116N-Glycan biosynthesis_Homo sapiens_hsa005100.24952095
117Collecting duct acid secretion_Homo sapiens_hsa049660.24791499
118Autoimmune thyroid disease_Homo sapiens_hsa053200.24014067
119Fructose and mannose metabolism_Homo sapiens_hsa000510.21881169
120Pyruvate metabolism_Homo sapiens_hsa006200.21789843
121MicroRNAs in cancer_Homo sapiens_hsa052060.21028436
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.21013398
123HIF-1 signaling pathway_Homo sapiens_hsa040660.20961025
124Renin-angiotensin system_Homo sapiens_hsa046140.20865643
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20119736
126Asthma_Homo sapiens_hsa053100.18967907
127Ether lipid metabolism_Homo sapiens_hsa005650.18863700
128Apoptosis_Homo sapiens_hsa042100.12702107
129Vibrio cholerae infection_Homo sapiens_hsa051100.12374201
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12150682
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11109325
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.10731905
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10424291
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10396400
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.10221690
136Rheumatoid arthritis_Homo sapiens_hsa053230.09889711
137Phagosome_Homo sapiens_hsa041450.09554810
138Hippo signaling pathway_Homo sapiens_hsa043900.09335272
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07811637
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07530848
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.05375324
142Measles_Homo sapiens_hsa051620.05023009
143Hematopoietic cell lineage_Homo sapiens_hsa046400.03009954

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