CBWD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory chain complex IV assembly (GO:0008535)4.80323923
2proteasome assembly (GO:0043248)4.79563491
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77431566
4cytochrome complex assembly (GO:0017004)4.38615338
5protein complex biogenesis (GO:0070271)4.36250674
6water-soluble vitamin biosynthetic process (GO:0042364)4.21409562
7mitochondrial respiratory chain complex assembly (GO:0033108)4.16345040
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07937230
9ATP synthesis coupled proton transport (GO:0015986)4.07306226
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07306226
11DNA double-strand break processing (GO:0000729)3.99406258
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91370997
13mitochondrial respiratory chain complex I assembly (GO:0032981)3.91370997
14NADH dehydrogenase complex assembly (GO:0010257)3.91370997
15cullin deneddylation (GO:0010388)3.81906234
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80646605
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.76918317
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74600756
19respiratory electron transport chain (GO:0022904)3.67306523
20electron transport chain (GO:0022900)3.63680428
21chaperone-mediated protein transport (GO:0072321)3.63566935
22rRNA modification (GO:0000154)3.60066813
23protein neddylation (GO:0045116)3.50341976
24lactate metabolic process (GO:0006089)3.46210736
25protein deneddylation (GO:0000338)3.44530969
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40155993
27regulation of mitochondrial translation (GO:0070129)3.35110161
28rRNA methylation (GO:0031167)3.28293518
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28281493
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27714389
31chromatin remodeling at centromere (GO:0031055)3.27356634
32CENP-A containing nucleosome assembly (GO:0034080)3.26929879
33regulation of cellular amino acid metabolic process (GO:0006521)3.26293551
34pseudouridine synthesis (GO:0001522)3.23767541
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23542706
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.21140193
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.20744042
38termination of RNA polymerase III transcription (GO:0006386)3.20744042
39DNA deamination (GO:0045006)3.19847502
40peptidyl-histidine modification (GO:0018202)3.16926953
41histone mRNA metabolic process (GO:0008334)3.13030349
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11481850
43DNA catabolic process, exonucleolytic (GO:0000738)3.08420435
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08051523
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08051523
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08051523
47maturation of 5.8S rRNA (GO:0000460)3.06073378
48organelle disassembly (GO:1903008)3.04697600
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02890866
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02890866
51double-strand break repair via homologous recombination (GO:0000724)3.02103643
52response to pheromone (GO:0019236)3.02091662
53recombinational repair (GO:0000725)3.01478876
54negative regulation of ligase activity (GO:0051352)3.00455377
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00455377
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99310815
57regulation of mitotic spindle checkpoint (GO:1903504)2.99310815
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98892028
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97903354
60somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97903354
61isotype switching (GO:0045190)2.97903354
62histone exchange (GO:0043486)2.97320387
63regulation of glucokinase activity (GO:0033131)2.96515005
64regulation of hexokinase activity (GO:1903299)2.96515005
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92785532
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92785532
67signal peptide processing (GO:0006465)2.92599540
68replication fork processing (GO:0031297)2.91813579
69signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91529642
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.91529642
71signal transduction involved in cell cycle checkpoint (GO:0072395)2.89993831
72protein-cofactor linkage (GO:0018065)2.87504447
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86698230
74ribosome assembly (GO:0042255)2.86346209
75platelet dense granule organization (GO:0060155)2.85328297
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84949648
77preassembly of GPI anchor in ER membrane (GO:0016254)2.83947395
78spliceosomal snRNP assembly (GO:0000387)2.80083116
79synapsis (GO:0007129)2.78453249
80tRNA processing (GO:0008033)2.78336315
81DNA damage response, detection of DNA damage (GO:0042769)2.78226567
82amino acid salvage (GO:0043102)2.77332334
83L-methionine salvage (GO:0071267)2.77332334
84L-methionine biosynthetic process (GO:0071265)2.77332334
85cellular ketone body metabolic process (GO:0046950)2.76401930
86regulation of helicase activity (GO:0051095)2.74513386
87positive regulation of ligase activity (GO:0051351)2.72312062
88protein targeting to mitochondrion (GO:0006626)2.72195483
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70741741
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.70741741
91telomere maintenance via telomerase (GO:0007004)2.64030463
92mannosylation (GO:0097502)2.64004316
93ribonucleoprotein complex disassembly (GO:0032988)2.61327878
94protein localization to mitochondrion (GO:0070585)2.59737377
95adenosine metabolic process (GO:0046085)2.59446963
96tRNA metabolic process (GO:0006399)2.58498111
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.56211020
98ketone body metabolic process (GO:1902224)2.55856453
99indolalkylamine metabolic process (GO:0006586)2.53781548
100positive regulation of histone H3-K4 methylation (GO:0051571)2.53322053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37824922
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.96300710
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.66981892
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21211821
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93233773
6ELK1_19687146_ChIP-ChIP_HELA_Human2.76965951
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75803323
8ZNF274_21170338_ChIP-Seq_K562_Hela2.66318288
9VDR_23849224_ChIP-Seq_CD4+_Human2.51195460
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44744501
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39154720
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34825248
13VDR_22108803_ChIP-Seq_LS180_Human2.32693064
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.30086255
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21307039
16EWS_26573619_Chip-Seq_HEK293_Human2.20760378
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.20427827
18FUS_26573619_Chip-Seq_HEK293_Human2.19379753
19IGF1R_20145208_ChIP-Seq_DFB_Human2.16913303
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13164981
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11897369
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10363071
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00794005
24FOXP3_21729870_ChIP-Seq_TREG_Human2.00254219
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97364310
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93888185
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90617485
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.80464272
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73978378
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71098540
31TAF15_26573619_Chip-Seq_HEK293_Human1.68320905
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.62472035
33P300_19829295_ChIP-Seq_ESCs_Human1.62046594
34MYC_18940864_ChIP-ChIP_HL60_Human1.61986650
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.58363060
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55685924
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.53127904
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48575521
39ER_23166858_ChIP-Seq_MCF-7_Human1.41412442
40DCP1A_22483619_ChIP-Seq_HELA_Human1.40512791
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40263495
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39498998
43E2F7_22180533_ChIP-Seq_HELA_Human1.38798824
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38112752
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34472803
46TP53_22573176_ChIP-Seq_HFKS_Human1.31557233
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30840936
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30381823
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.29924173
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28638759
51* GBX2_23144817_ChIP-Seq_PC3_Human1.28150901
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.27073895
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26697954
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24637000
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20381331
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20247098
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19934724
58GABP_19822575_ChIP-Seq_HepG2_Human1.19567022
59IRF1_19129219_ChIP-ChIP_H3396_Human1.18326998
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17589103
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17574279
62CBP_20019798_ChIP-Seq_JUKART_Human1.17574279
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17047466
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15192783
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.14805361
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14805361
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14314704
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14008765
69SOX2_19829295_ChIP-Seq_ESCs_Human1.13693199
70NANOG_19829295_ChIP-Seq_ESCs_Human1.13693199
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12610549
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09525454
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.09344591
74TTF2_22483619_ChIP-Seq_HELA_Human1.05837810
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03208614
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02861685
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02543390
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02205557
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00952987
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00324095
81HTT_18923047_ChIP-ChIP_STHdh_Human1.00083720
82NANOG_18555785_Chip-Seq_ESCs_Mouse0.99742773
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99126037
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98992161
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98349674
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97409967
87P53_22387025_ChIP-Seq_ESCs_Mouse0.97108811
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.96791084
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96283690
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96282896
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96116125
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96024240
93P300_18555785_Chip-Seq_ESCs_Mouse0.95627537
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95507043
95TCF4_22108803_ChIP-Seq_LS180_Human0.95505767
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.95220735
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.95024589
98BCAT_22108803_ChIP-Seq_LS180_Human0.94346126
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94300132
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93838879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.37081554
2MP0008058_abnormal_DNA_repair3.30263136
3MP0008877_abnormal_DNA_methylation3.17572194
4MP0002102_abnormal_ear_morphology2.91777507
5MP0008057_abnormal_DNA_replication2.61092445
6MP0002837_dystrophic_cardiac_calcinosis2.46883312
7MP0010094_abnormal_chromosome_stability2.42872716
8MP0003806_abnormal_nucleotide_metabolis2.39400805
9MP0003787_abnormal_imprinting2.37780259
10MP0006072_abnormal_retinal_apoptosis2.27400645
11MP0006036_abnormal_mitochondrial_physio2.14787987
12MP0003718_maternal_effect2.06619135
13MP0003786_premature_aging2.06286189
14MP0005075_abnormal_melanosome_morpholog1.96455168
15MP0000372_irregular_coat_pigmentation1.88676599
16MP0003186_abnormal_redox_activity1.78312932
17MP0005645_abnormal_hypothalamus_physiol1.77870010
18MP0002163_abnormal_gland_morphology1.71655365
19MP0005551_abnormal_eye_electrophysiolog1.70817360
20MP0004147_increased_porphyrin_level1.68382719
21MP0006292_abnormal_olfactory_placode1.64698199
22MP0005379_endocrine/exocrine_gland_phen1.63142912
23MP0003121_genomic_imprinting1.60210202
24MP0005253_abnormal_eye_physiology1.59928813
25MP0005084_abnormal_gallbladder_morpholo1.59443367
26MP0006035_abnormal_mitochondrial_morpho1.58847846
27MP0008995_early_reproductive_senescence1.56562471
28MP0008872_abnormal_physiological_respon1.56111131
29MP0000569_abnormal_digit_pigmentation1.54461122
30MP0001984_abnormal_olfaction1.53752288
31MP0004957_abnormal_blastocyst_morpholog1.53488473
32MP0009046_muscle_twitch1.52773425
33MP0008875_abnormal_xenobiotic_pharmacok1.52649067
34MP0001529_abnormal_vocalization1.50766965
35MP0002938_white_spotting1.47315090
36MP0003693_abnormal_embryo_hatching1.46190188
37MP0001764_abnormal_homeostasis1.40985705
38MP0008007_abnormal_cellular_replicative1.39915758
39MP0009697_abnormal_copulation1.38659982
40MP0002638_abnormal_pupillary_reflex1.36748166
41MP0002876_abnormal_thyroid_physiology1.35380211
42MP0003880_abnormal_central_pattern1.31819932
43MP0010386_abnormal_urinary_bladder1.30477927
44MP0005646_abnormal_pituitary_gland1.28422744
45MP0002160_abnormal_reproductive_system1.23559666
46MP0003111_abnormal_nucleus_morphology1.23184041
47MP0004142_abnormal_muscle_tone1.22333680
48MP0003077_abnormal_cell_cycle1.20899797
49MP0004215_abnormal_myocardial_fiber1.20353997
50MP0005389_reproductive_system_phenotype1.20180176
51MP0005367_renal/urinary_system_phenotyp1.19358049
52MP0000516_abnormal_urinary_system1.19358049
53MP0006054_spinal_hemorrhage1.18554074
54MP0002254_reproductive_system_inflammat1.17637711
55MP0006276_abnormal_autonomic_nervous1.16532947
56MP0002736_abnormal_nociception_after1.13248968
57MP0000427_abnormal_hair_cycle1.09172230
58MP0005636_abnormal_mineral_homeostasis1.09103327
59MP0003646_muscle_fatigue1.07789139
60MP0002693_abnormal_pancreas_physiology1.04300904
61MP0001986_abnormal_taste_sensitivity1.03107203
62MP0001929_abnormal_gametogenesis0.97730268
63MP0002277_abnormal_respiratory_mucosa0.97254898
64MP0001485_abnormal_pinna_reflex0.95744232
65MP0001968_abnormal_touch/_nociception0.94443027
66MP0005332_abnormal_amino_acid0.93913238
67MP0004145_abnormal_muscle_electrophysio0.93657679
68MP0003567_abnormal_fetal_cardiomyocyte0.92160060
69MP0001905_abnormal_dopamine_level0.92016435
70MP0005410_abnormal_fertilization0.91879786
71MP0000631_abnormal_neuroendocrine_gland0.91447733
72MP0002095_abnormal_skin_pigmentation0.90639734
73MP0003011_delayed_dark_adaptation0.89339244
74MP0004043_abnormal_pH_regulation0.89047925
75MP0000647_abnormal_sebaceous_gland0.88178916
76MP0005266_abnormal_metabolism0.88111096
77MP0008789_abnormal_olfactory_epithelium0.87352572
78MP0002090_abnormal_vision0.87006625
79MP0002751_abnormal_autonomic_nervous0.85755016
80MP0003122_maternal_imprinting0.85662174
81MP0001919_abnormal_reproductive_system0.84272075
82MP0003890_abnormal_embryonic-extraembry0.83384569
83MP0000653_abnormal_sex_gland0.80637742
84MP0008932_abnormal_embryonic_tissue0.79897649
85MP0002272_abnormal_nervous_system0.79810769
86MP0009745_abnormal_behavioral_response0.79406364
87MP0002210_abnormal_sex_determination0.79081416
88MP0001501_abnormal_sleep_pattern0.78636911
89MP0005395_other_phenotype0.78131422
90MP0005220_abnormal_exocrine_pancreas0.75230156
91MP0004924_abnormal_behavior0.74565608
92MP0005386_behavior/neurological_phenoty0.74565608
93MP0005408_hypopigmentation0.74414086
94MP0001145_abnormal_male_reproductive0.73991884
95MP0000358_abnormal_cell_content/0.73317792
96MP0001293_anophthalmia0.73067862
97MP0003698_abnormal_male_reproductive0.69163130
98MP0004133_heterotaxia0.67630287
99MP0001944_abnormal_pancreas_morphology0.67439588
100MP0005174_abnormal_tail_pigmentation0.66114802

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.97959544
2Mitochondrial inheritance (HP:0001427)3.67168870
3Increased CSF lactate (HP:0002490)3.65232972
4Progressive macrocephaly (HP:0004481)3.63255795
5Acute encephalopathy (HP:0006846)3.52119227
63-Methylglutaconic aciduria (HP:0003535)3.48208216
7Methylmalonic acidemia (HP:0002912)3.45366585
8Abnormal mitochondria in muscle tissue (HP:0008316)3.43158885
9Increased hepatocellular lipid droplets (HP:0006565)3.37070910
10Hepatocellular necrosis (HP:0001404)3.31105555
11Hepatic necrosis (HP:0002605)3.31083201
12Lipid accumulation in hepatocytes (HP:0006561)3.19500973
13Pancreatic cysts (HP:0001737)3.18488033
14Hypothermia (HP:0002045)2.95985432
15Pancreatic fibrosis (HP:0100732)2.75560873
16Methylmalonic aciduria (HP:0012120)2.74289376
17Cerebral edema (HP:0002181)2.72094703
18Increased serum lactate (HP:0002151)2.64021872
19True hermaphroditism (HP:0010459)2.64007550
20Congenital stationary night blindness (HP:0007642)2.61556474
21Medial flaring of the eyebrow (HP:0010747)2.61431320
22Abnormality of the renal cortex (HP:0011035)2.53820811
23Hypoglycemic coma (HP:0001325)2.52894486
24Abnormality of methionine metabolism (HP:0010901)2.51489627
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50967755
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50967755
27Abnormality of midbrain morphology (HP:0002418)2.49821926
28Molar tooth sign on MRI (HP:0002419)2.49821926
29Lactic acidosis (HP:0003128)2.48295732
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46119346
31Abnormality of alanine metabolism (HP:0010916)2.46119346
32Hyperalaninemia (HP:0003348)2.46119346
33Nephronophthisis (HP:0000090)2.44414548
34Abnormality of vitamin B metabolism (HP:0004340)2.42674976
35Renal Fanconi syndrome (HP:0001994)2.42623261
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40211136
37Renal cortical cysts (HP:0000803)2.39004523
38Abnormal protein glycosylation (HP:0012346)2.35926774
39Abnormal glycosylation (HP:0012345)2.35926774
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35926774
41Abnormal protein N-linked glycosylation (HP:0012347)2.35926774
42Respiratory failure (HP:0002878)2.28518620
43Abnormality of chromosome stability (HP:0003220)2.27230629
44Exertional dyspnea (HP:0002875)2.25721913
45Hyperinsulinemic hypoglycemia (HP:0000825)2.21941169
46Abnormality of the renal medulla (HP:0100957)2.19030041
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.18465330
48Abnormality of the labia minora (HP:0012880)2.18463944
49Abnormality of serum amino acid levels (HP:0003112)2.18035715
50Abolished electroretinogram (ERG) (HP:0000550)2.17924579
51Congenital, generalized hypertrichosis (HP:0004540)2.17837340
52Optic disc pallor (HP:0000543)2.16473359
53Lethargy (HP:0001254)2.13315232
54Type I transferrin isoform profile (HP:0003642)2.12962428
55Glycosuria (HP:0003076)2.08910306
56Abnormality of urine glucose concentration (HP:0011016)2.08910306
57Increased intramyocellular lipid droplets (HP:0012240)2.08712660
58Hypoglycemic seizures (HP:0002173)2.08651408
59Meckel diverticulum (HP:0002245)2.06061344
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04546120
61Ketoacidosis (HP:0001993)2.03172154
62Intestinal atresia (HP:0011100)2.00934196
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00521461
64Congenital primary aphakia (HP:0007707)2.00156823
65Colon cancer (HP:0003003)1.99750328
66Abnormality of the ileum (HP:0001549)1.97924337
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.97533937
68Hyperglycinemia (HP:0002154)1.96968402
69Large for gestational age (HP:0001520)1.91963396
70CNS demyelination (HP:0007305)1.91173931
71Aplasia/hypoplasia of the uterus (HP:0008684)1.90989407
72Reduced antithrombin III activity (HP:0001976)1.89203426
73Abnormality of the preputium (HP:0100587)1.88524874
74Gait imbalance (HP:0002141)1.87945743
75Nephrogenic diabetes insipidus (HP:0009806)1.85923211
76Volvulus (HP:0002580)1.85749206
77Bile duct proliferation (HP:0001408)1.85730493
78Abnormal biliary tract physiology (HP:0012439)1.85730493
79Exercise intolerance (HP:0003546)1.85660484
80Abnormality of macular pigmentation (HP:0008002)1.84616957
81Constricted visual fields (HP:0001133)1.84456171
82Increased serum pyruvate (HP:0003542)1.84410843
83Leukodystrophy (HP:0002415)1.83219694
84Abnormality of the anterior horn cell (HP:0006802)1.80836359
85Degeneration of anterior horn cells (HP:0002398)1.80836359
86Respiratory difficulties (HP:0002880)1.80218594
87Abnormality of the pons (HP:0007361)1.80189304
88Furrowed tongue (HP:0000221)1.79200577
89Aplastic anemia (HP:0001915)1.77843507
90Abnormality of renal resorption (HP:0011038)1.76128220
91Chromsome breakage (HP:0040012)1.75920518
92Neoplasm of the adrenal gland (HP:0100631)1.75630107
93Hypomagnesemia (HP:0002917)1.74875806
94Generalized aminoaciduria (HP:0002909)1.74867346
95Microvesicular hepatic steatosis (HP:0001414)1.74852273
96Pancreatic islet-cell hyperplasia (HP:0004510)1.74578112
97Genital tract atresia (HP:0001827)1.71590452
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70187038
99Dicarboxylic aciduria (HP:0003215)1.70187038
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.69590416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.95359984
2MST43.71915333
3EIF2AK32.99062106
4MAP4K22.93178072
5EIF2AK12.69533669
6BMPR1B2.42702484
7ZAK2.36193436
8WNK32.28583465
9TRIM282.26729039
10NUAK12.19790044
11STK162.01238626
12SRPK11.99934301
13BUB11.93614807
14ACVR1B1.90816711
15MKNK21.88320786
16VRK21.87891012
17NME11.81986546
18MKNK11.74762016
19PLK41.72166720
20ERBB31.72148572
21MAP3K121.69560655
22PLK31.64046614
23GRK11.61435740
24PBK1.57934160
25ADRBK21.55747439
26VRK11.54496284
27TSSK61.52654704
28OXSR11.48207924
29TNIK1.41914284
30PLK21.38035848
31BCR1.29704654
32MAP3K41.29242693
33BRSK21.28927120
34INSRR1.28366407
35NEK11.21604370
36PINK11.18314247
37TLK11.15708613
38CDC71.11870401
39STK391.07722046
40CSNK1G11.01877365
41TXK1.00714618
42EIF2AK20.92522389
43WNK40.91499770
44CSNK1G30.91270647
45STK38L0.89467564
46PDK20.88552714
47BCKDK0.88481964
48CSNK1G20.87794246
49TAF10.82701156
50TAOK30.82540196
51PLK10.81389641
52CASK0.81189235
53TTK0.80229621
54PAK30.78349581
55PRKCE0.68867736
56PASK0.68719448
57STK30.68249809
58CSNK1A1L0.67615815
59WEE10.65083231
60TEC0.64264337
61MAPK130.63059440
62ATR0.62912989
63PHKG20.62260789
64PHKG10.62260789
65OBSCN0.61439308
66CDK190.57909715
67MAP2K70.57529660
68ATM0.57427377
69BMPR20.54664127
70DYRK20.52571166
71NLK0.51204293
72FLT30.49191651
73TGFBR10.48965484
74FGFR20.48393732
75CAMKK20.48210766
76CSNK2A10.47878613
77CSNK2A20.47789057
78IKBKB0.44757131
79RPS6KA50.44743750
80PRKCG0.43497698
81AURKB0.41901876
82DAPK20.40358668
83CDK30.40218733
84DAPK10.37348026
85PIK3CA0.37198767
86RPS6KA40.36540185
87CSNK1E0.35170239
88MAP2K60.34489667
89PIK3CG0.34479859
90MAPKAPK50.34424943
91TRPM70.33903427
92FER0.33588132
93CHEK20.32249931
94STK240.32242749
95TIE10.31984353
96CSNK1A10.29528123
97STK40.27971305
98DYRK30.27601554
99CCNB10.27529616
100ADRBK10.27506183

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.07774664
2Proteasome_Homo sapiens_hsa030503.98189216
3Oxidative phosphorylation_Homo sapiens_hsa001903.40714161
4Parkinsons disease_Homo sapiens_hsa050122.70731594
5Homologous recombination_Homo sapiens_hsa034402.59913152
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58755642
7RNA polymerase_Homo sapiens_hsa030202.52127166
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42916945
9Non-homologous end-joining_Homo sapiens_hsa034502.38874157
10Mismatch repair_Homo sapiens_hsa034302.28758224
11Propanoate metabolism_Homo sapiens_hsa006402.20722306
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13143860
13Basal transcription factors_Homo sapiens_hsa030222.09556767
14RNA degradation_Homo sapiens_hsa030181.93492782
15Huntingtons disease_Homo sapiens_hsa050161.88019215
16Fanconi anemia pathway_Homo sapiens_hsa034601.84795673
17Ribosome_Homo sapiens_hsa030101.81423635
18Alzheimers disease_Homo sapiens_hsa050101.72233501
19Butanoate metabolism_Homo sapiens_hsa006501.71402093
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66548289
21DNA replication_Homo sapiens_hsa030301.64313909
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.58583454
23Spliceosome_Homo sapiens_hsa030401.57294759
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56429204
25RNA transport_Homo sapiens_hsa030131.55594425
26Nucleotide excision repair_Homo sapiens_hsa034201.53675817
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52332581
28One carbon pool by folate_Homo sapiens_hsa006701.50529547
29Selenocompound metabolism_Homo sapiens_hsa004501.47440172
30Fatty acid elongation_Homo sapiens_hsa000621.45772135
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41828822
32Phototransduction_Homo sapiens_hsa047441.36515225
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35556767
34Pyrimidine metabolism_Homo sapiens_hsa002401.27004976
35Base excision repair_Homo sapiens_hsa034101.25398153
36Tryptophan metabolism_Homo sapiens_hsa003801.23255845
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22577479
38Steroid biosynthesis_Homo sapiens_hsa001001.11340313
39Purine metabolism_Homo sapiens_hsa002301.10958130
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.03940102
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03144067
42Collecting duct acid secretion_Homo sapiens_hsa049661.02560075
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98456698
44Sulfur metabolism_Homo sapiens_hsa009200.97415457
45Peroxisome_Homo sapiens_hsa041460.95115907
46Cardiac muscle contraction_Homo sapiens_hsa042600.94654306
47Caffeine metabolism_Homo sapiens_hsa002320.94534492
48Vitamin B6 metabolism_Homo sapiens_hsa007500.94474953
49Nitrogen metabolism_Homo sapiens_hsa009100.92923378
50Pyruvate metabolism_Homo sapiens_hsa006200.91938914
51Regulation of autophagy_Homo sapiens_hsa041400.86117120
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85220595
53Type I diabetes mellitus_Homo sapiens_hsa049400.83415866
54Linoleic acid metabolism_Homo sapiens_hsa005910.79348883
55Folate biosynthesis_Homo sapiens_hsa007900.78005217
56Asthma_Homo sapiens_hsa053100.77676365
57Metabolic pathways_Homo sapiens_hsa011000.77233602
58Glutathione metabolism_Homo sapiens_hsa004800.68891350
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68641172
60Ether lipid metabolism_Homo sapiens_hsa005650.68415104
61Circadian rhythm_Homo sapiens_hsa047100.66911768
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66116101
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63882945
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63507105
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63004676
66Chemical carcinogenesis_Homo sapiens_hsa052040.62534901
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.61725156
68Fatty acid metabolism_Homo sapiens_hsa012120.59109154
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57912882
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.57446234
71beta-Alanine metabolism_Homo sapiens_hsa004100.57219642
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56819394
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55697395
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55061940
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53470992
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50996740
77Fatty acid degradation_Homo sapiens_hsa000710.48360879
78Retinol metabolism_Homo sapiens_hsa008300.47207046
79Oocyte meiosis_Homo sapiens_hsa041140.46309589
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.44346138
81Rheumatoid arthritis_Homo sapiens_hsa053230.42594863
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42426333
83mRNA surveillance pathway_Homo sapiens_hsa030150.40478918
84Olfactory transduction_Homo sapiens_hsa047400.40229207
85Cell cycle_Homo sapiens_hsa041100.38843813
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38044442
87N-Glycan biosynthesis_Homo sapiens_hsa005100.36282072
88Allograft rejection_Homo sapiens_hsa053300.36204300
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35902269
90p53 signaling pathway_Homo sapiens_hsa041150.32205843
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.31251273
92Autoimmune thyroid disease_Homo sapiens_hsa053200.30918985
93Taste transduction_Homo sapiens_hsa047420.30870335
94Vitamin digestion and absorption_Homo sapiens_hsa049770.30782917
95Legionellosis_Homo sapiens_hsa051340.30451659
96Carbon metabolism_Homo sapiens_hsa012000.29542127
97Nicotine addiction_Homo sapiens_hsa050330.27607318
98Primary immunodeficiency_Homo sapiens_hsa053400.22216774
99Mineral absorption_Homo sapiens_hsa049780.22113995
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21131737

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