

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | respiratory chain complex IV assembly (GO:0008535) | 4.80323923 |
| 2 | proteasome assembly (GO:0043248) | 4.79563491 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.77431566 |
| 4 | cytochrome complex assembly (GO:0017004) | 4.38615338 |
| 5 | protein complex biogenesis (GO:0070271) | 4.36250674 |
| 6 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.21409562 |
| 7 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.16345040 |
| 8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.07937230 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 4.07306226 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.07306226 |
| 11 | DNA double-strand break processing (GO:0000729) | 3.99406258 |
| 12 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.91370997 |
| 13 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.91370997 |
| 14 | NADH dehydrogenase complex assembly (GO:0010257) | 3.91370997 |
| 15 | cullin deneddylation (GO:0010388) | 3.81906234 |
| 16 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.80646605 |
| 17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.76918317 |
| 18 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.74600756 |
| 19 | respiratory electron transport chain (GO:0022904) | 3.67306523 |
| 20 | electron transport chain (GO:0022900) | 3.63680428 |
| 21 | chaperone-mediated protein transport (GO:0072321) | 3.63566935 |
| 22 | rRNA modification (GO:0000154) | 3.60066813 |
| 23 | protein neddylation (GO:0045116) | 3.50341976 |
| 24 | lactate metabolic process (GO:0006089) | 3.46210736 |
| 25 | protein deneddylation (GO:0000338) | 3.44530969 |
| 26 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.40155993 |
| 27 | regulation of mitochondrial translation (GO:0070129) | 3.35110161 |
| 28 | rRNA methylation (GO:0031167) | 3.28293518 |
| 29 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.28281493 |
| 30 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.27714389 |
| 31 | chromatin remodeling at centromere (GO:0031055) | 3.27356634 |
| 32 | CENP-A containing nucleosome assembly (GO:0034080) | 3.26929879 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.26293551 |
| 34 | pseudouridine synthesis (GO:0001522) | 3.23767541 |
| 35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.23542706 |
| 36 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.21140193 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.20744042 |
| 38 | termination of RNA polymerase III transcription (GO:0006386) | 3.20744042 |
| 39 | DNA deamination (GO:0045006) | 3.19847502 |
| 40 | peptidyl-histidine modification (GO:0018202) | 3.16926953 |
| 41 | histone mRNA metabolic process (GO:0008334) | 3.13030349 |
| 42 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.11481850 |
| 43 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.08420435 |
| 44 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.08051523 |
| 45 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.08051523 |
| 46 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.08051523 |
| 47 | maturation of 5.8S rRNA (GO:0000460) | 3.06073378 |
| 48 | organelle disassembly (GO:1903008) | 3.04697600 |
| 49 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.02890866 |
| 50 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.02890866 |
| 51 | double-strand break repair via homologous recombination (GO:0000724) | 3.02103643 |
| 52 | response to pheromone (GO:0019236) | 3.02091662 |
| 53 | recombinational repair (GO:0000725) | 3.01478876 |
| 54 | negative regulation of ligase activity (GO:0051352) | 3.00455377 |
| 55 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.00455377 |
| 56 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.99310815 |
| 57 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.99310815 |
| 58 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.98892028 |
| 59 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.97903354 |
| 60 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.97903354 |
| 61 | isotype switching (GO:0045190) | 2.97903354 |
| 62 | histone exchange (GO:0043486) | 2.97320387 |
| 63 | regulation of glucokinase activity (GO:0033131) | 2.96515005 |
| 64 | regulation of hexokinase activity (GO:1903299) | 2.96515005 |
| 65 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.92785532 |
| 66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.92785532 |
| 67 | signal peptide processing (GO:0006465) | 2.92599540 |
| 68 | replication fork processing (GO:0031297) | 2.91813579 |
| 69 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.91529642 |
| 70 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.91529642 |
| 71 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.89993831 |
| 72 | protein-cofactor linkage (GO:0018065) | 2.87504447 |
| 73 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.86698230 |
| 74 | ribosome assembly (GO:0042255) | 2.86346209 |
| 75 | platelet dense granule organization (GO:0060155) | 2.85328297 |
| 76 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.84949648 |
| 77 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.83947395 |
| 78 | spliceosomal snRNP assembly (GO:0000387) | 2.80083116 |
| 79 | synapsis (GO:0007129) | 2.78453249 |
| 80 | tRNA processing (GO:0008033) | 2.78336315 |
| 81 | DNA damage response, detection of DNA damage (GO:0042769) | 2.78226567 |
| 82 | amino acid salvage (GO:0043102) | 2.77332334 |
| 83 | L-methionine salvage (GO:0071267) | 2.77332334 |
| 84 | L-methionine biosynthetic process (GO:0071265) | 2.77332334 |
| 85 | cellular ketone body metabolic process (GO:0046950) | 2.76401930 |
| 86 | regulation of helicase activity (GO:0051095) | 2.74513386 |
| 87 | positive regulation of ligase activity (GO:0051351) | 2.72312062 |
| 88 | protein targeting to mitochondrion (GO:0006626) | 2.72195483 |
| 89 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.70741741 |
| 90 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.70741741 |
| 91 | telomere maintenance via telomerase (GO:0007004) | 2.64030463 |
| 92 | mannosylation (GO:0097502) | 2.64004316 |
| 93 | ribonucleoprotein complex disassembly (GO:0032988) | 2.61327878 |
| 94 | protein localization to mitochondrion (GO:0070585) | 2.59737377 |
| 95 | adenosine metabolic process (GO:0046085) | 2.59446963 |
| 96 | tRNA metabolic process (GO:0006399) | 2.58498111 |
| 97 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.56211020 |
| 98 | ketone body metabolic process (GO:1902224) | 2.55856453 |
| 99 | indolalkylamine metabolic process (GO:0006586) | 2.53781548 |
| 100 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.53322053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.37824922 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.96300710 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.66981892 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.21211821 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.93233773 |
| 6 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.76965951 |
| 7 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.75803323 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.66318288 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.51195460 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.44744501 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.39154720 |
| 12 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.34825248 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.32693064 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.30086255 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.21307039 |
| 16 | EWS_26573619_Chip-Seq_HEK293_Human | 2.20760378 |
| 17 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.20427827 |
| 18 | FUS_26573619_Chip-Seq_HEK293_Human | 2.19379753 |
| 19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.16913303 |
| 20 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.13164981 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.11897369 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.10363071 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.00794005 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.00254219 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.97364310 |
| 26 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.93888185 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.90617485 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.80464272 |
| 29 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.73978378 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.71098540 |
| 31 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.68320905 |
| 32 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.62472035 |
| 33 | P300_19829295_ChIP-Seq_ESCs_Human | 1.62046594 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.61986650 |
| 35 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.58363060 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.55685924 |
| 37 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.53127904 |
| 38 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.48575521 |
| 39 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.41412442 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.40512791 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40263495 |
| 42 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.39498998 |
| 43 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.38798824 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.38112752 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.34472803 |
| 46 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.31557233 |
| 47 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.30840936 |
| 48 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.30381823 |
| 49 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.29924173 |
| 50 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.28638759 |
| 51 | * GBX2_23144817_ChIP-Seq_PC3_Human | 1.28150901 |
| 52 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.27073895 |
| 53 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26697954 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24637000 |
| 55 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.20381331 |
| 56 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.20247098 |
| 57 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.19934724 |
| 58 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.19567022 |
| 59 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.18326998 |
| 60 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.17589103 |
| 61 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.17574279 |
| 62 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.17574279 |
| 63 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.17047466 |
| 64 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.15192783 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.14805361 |
| 66 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.14805361 |
| 67 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.14314704 |
| 68 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14008765 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.13693199 |
| 70 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.13693199 |
| 71 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12610549 |
| 72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.09525454 |
| 73 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.09344591 |
| 74 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.05837810 |
| 75 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.03208614 |
| 76 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.02861685 |
| 77 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.02543390 |
| 78 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.02205557 |
| 79 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.00952987 |
| 80 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.00324095 |
| 81 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.00083720 |
| 82 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.99742773 |
| 83 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.99126037 |
| 84 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98992161 |
| 85 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.98349674 |
| 86 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.97409967 |
| 87 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97108811 |
| 88 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.96791084 |
| 89 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.96283690 |
| 90 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.96282896 |
| 91 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.96116125 |
| 92 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96024240 |
| 93 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.95627537 |
| 94 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.95507043 |
| 95 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.95505767 |
| 96 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.95220735 |
| 97 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.95024589 |
| 98 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.94346126 |
| 99 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.94300132 |
| 100 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.93838879 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003195_calcinosis | 3.37081554 |
| 2 | MP0008058_abnormal_DNA_repair | 3.30263136 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.17572194 |
| 4 | MP0002102_abnormal_ear_morphology | 2.91777507 |
| 5 | MP0008057_abnormal_DNA_replication | 2.61092445 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 2.46883312 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.42872716 |
| 8 | MP0003806_abnormal_nucleotide_metabolis | 2.39400805 |
| 9 | MP0003787_abnormal_imprinting | 2.37780259 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.27400645 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.14787987 |
| 12 | MP0003718_maternal_effect | 2.06619135 |
| 13 | MP0003786_premature_aging | 2.06286189 |
| 14 | MP0005075_abnormal_melanosome_morpholog | 1.96455168 |
| 15 | MP0000372_irregular_coat_pigmentation | 1.88676599 |
| 16 | MP0003186_abnormal_redox_activity | 1.78312932 |
| 17 | MP0005645_abnormal_hypothalamus_physiol | 1.77870010 |
| 18 | MP0002163_abnormal_gland_morphology | 1.71655365 |
| 19 | MP0005551_abnormal_eye_electrophysiolog | 1.70817360 |
| 20 | MP0004147_increased_porphyrin_level | 1.68382719 |
| 21 | MP0006292_abnormal_olfactory_placode | 1.64698199 |
| 22 | MP0005379_endocrine/exocrine_gland_phen | 1.63142912 |
| 23 | MP0003121_genomic_imprinting | 1.60210202 |
| 24 | MP0005253_abnormal_eye_physiology | 1.59928813 |
| 25 | MP0005084_abnormal_gallbladder_morpholo | 1.59443367 |
| 26 | MP0006035_abnormal_mitochondrial_morpho | 1.58847846 |
| 27 | MP0008995_early_reproductive_senescence | 1.56562471 |
| 28 | MP0008872_abnormal_physiological_respon | 1.56111131 |
| 29 | MP0000569_abnormal_digit_pigmentation | 1.54461122 |
| 30 | MP0001984_abnormal_olfaction | 1.53752288 |
| 31 | MP0004957_abnormal_blastocyst_morpholog | 1.53488473 |
| 32 | MP0009046_muscle_twitch | 1.52773425 |
| 33 | MP0008875_abnormal_xenobiotic_pharmacok | 1.52649067 |
| 34 | MP0001529_abnormal_vocalization | 1.50766965 |
| 35 | MP0002938_white_spotting | 1.47315090 |
| 36 | MP0003693_abnormal_embryo_hatching | 1.46190188 |
| 37 | MP0001764_abnormal_homeostasis | 1.40985705 |
| 38 | MP0008007_abnormal_cellular_replicative | 1.39915758 |
| 39 | MP0009697_abnormal_copulation | 1.38659982 |
| 40 | MP0002638_abnormal_pupillary_reflex | 1.36748166 |
| 41 | MP0002876_abnormal_thyroid_physiology | 1.35380211 |
| 42 | MP0003880_abnormal_central_pattern | 1.31819932 |
| 43 | MP0010386_abnormal_urinary_bladder | 1.30477927 |
| 44 | MP0005646_abnormal_pituitary_gland | 1.28422744 |
| 45 | MP0002160_abnormal_reproductive_system | 1.23559666 |
| 46 | MP0003111_abnormal_nucleus_morphology | 1.23184041 |
| 47 | MP0004142_abnormal_muscle_tone | 1.22333680 |
| 48 | MP0003077_abnormal_cell_cycle | 1.20899797 |
| 49 | MP0004215_abnormal_myocardial_fiber | 1.20353997 |
| 50 | MP0005389_reproductive_system_phenotype | 1.20180176 |
| 51 | MP0005367_renal/urinary_system_phenotyp | 1.19358049 |
| 52 | MP0000516_abnormal_urinary_system | 1.19358049 |
| 53 | MP0006054_spinal_hemorrhage | 1.18554074 |
| 54 | MP0002254_reproductive_system_inflammat | 1.17637711 |
| 55 | MP0006276_abnormal_autonomic_nervous | 1.16532947 |
| 56 | MP0002736_abnormal_nociception_after | 1.13248968 |
| 57 | MP0000427_abnormal_hair_cycle | 1.09172230 |
| 58 | MP0005636_abnormal_mineral_homeostasis | 1.09103327 |
| 59 | MP0003646_muscle_fatigue | 1.07789139 |
| 60 | MP0002693_abnormal_pancreas_physiology | 1.04300904 |
| 61 | MP0001986_abnormal_taste_sensitivity | 1.03107203 |
| 62 | MP0001929_abnormal_gametogenesis | 0.97730268 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 0.97254898 |
| 64 | MP0001485_abnormal_pinna_reflex | 0.95744232 |
| 65 | MP0001968_abnormal_touch/_nociception | 0.94443027 |
| 66 | MP0005332_abnormal_amino_acid | 0.93913238 |
| 67 | MP0004145_abnormal_muscle_electrophysio | 0.93657679 |
| 68 | MP0003567_abnormal_fetal_cardiomyocyte | 0.92160060 |
| 69 | MP0001905_abnormal_dopamine_level | 0.92016435 |
| 70 | MP0005410_abnormal_fertilization | 0.91879786 |
| 71 | MP0000631_abnormal_neuroendocrine_gland | 0.91447733 |
| 72 | MP0002095_abnormal_skin_pigmentation | 0.90639734 |
| 73 | MP0003011_delayed_dark_adaptation | 0.89339244 |
| 74 | MP0004043_abnormal_pH_regulation | 0.89047925 |
| 75 | MP0000647_abnormal_sebaceous_gland | 0.88178916 |
| 76 | MP0005266_abnormal_metabolism | 0.88111096 |
| 77 | MP0008789_abnormal_olfactory_epithelium | 0.87352572 |
| 78 | MP0002090_abnormal_vision | 0.87006625 |
| 79 | MP0002751_abnormal_autonomic_nervous | 0.85755016 |
| 80 | MP0003122_maternal_imprinting | 0.85662174 |
| 81 | MP0001919_abnormal_reproductive_system | 0.84272075 |
| 82 | MP0003890_abnormal_embryonic-extraembry | 0.83384569 |
| 83 | MP0000653_abnormal_sex_gland | 0.80637742 |
| 84 | MP0008932_abnormal_embryonic_tissue | 0.79897649 |
| 85 | MP0002272_abnormal_nervous_system | 0.79810769 |
| 86 | MP0009745_abnormal_behavioral_response | 0.79406364 |
| 87 | MP0002210_abnormal_sex_determination | 0.79081416 |
| 88 | MP0001501_abnormal_sleep_pattern | 0.78636911 |
| 89 | MP0005395_other_phenotype | 0.78131422 |
| 90 | MP0005220_abnormal_exocrine_pancreas | 0.75230156 |
| 91 | MP0004924_abnormal_behavior | 0.74565608 |
| 92 | MP0005386_behavior/neurological_phenoty | 0.74565608 |
| 93 | MP0005408_hypopigmentation | 0.74414086 |
| 94 | MP0001145_abnormal_male_reproductive | 0.73991884 |
| 95 | MP0000358_abnormal_cell_content/ | 0.73317792 |
| 96 | MP0001293_anophthalmia | 0.73067862 |
| 97 | MP0003698_abnormal_male_reproductive | 0.69163130 |
| 98 | MP0004133_heterotaxia | 0.67630287 |
| 99 | MP0001944_abnormal_pancreas_morphology | 0.67439588 |
| 100 | MP0005174_abnormal_tail_pigmentation | 0.66114802 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.97959544 |
| 2 | Mitochondrial inheritance (HP:0001427) | 3.67168870 |
| 3 | Increased CSF lactate (HP:0002490) | 3.65232972 |
| 4 | Progressive macrocephaly (HP:0004481) | 3.63255795 |
| 5 | Acute encephalopathy (HP:0006846) | 3.52119227 |
| 6 | 3-Methylglutaconic aciduria (HP:0003535) | 3.48208216 |
| 7 | Methylmalonic acidemia (HP:0002912) | 3.45366585 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.43158885 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37070910 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.31105555 |
| 11 | Hepatic necrosis (HP:0002605) | 3.31083201 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.19500973 |
| 13 | Pancreatic cysts (HP:0001737) | 3.18488033 |
| 14 | Hypothermia (HP:0002045) | 2.95985432 |
| 15 | Pancreatic fibrosis (HP:0100732) | 2.75560873 |
| 16 | Methylmalonic aciduria (HP:0012120) | 2.74289376 |
| 17 | Cerebral edema (HP:0002181) | 2.72094703 |
| 18 | Increased serum lactate (HP:0002151) | 2.64021872 |
| 19 | True hermaphroditism (HP:0010459) | 2.64007550 |
| 20 | Congenital stationary night blindness (HP:0007642) | 2.61556474 |
| 21 | Medial flaring of the eyebrow (HP:0010747) | 2.61431320 |
| 22 | Abnormality of the renal cortex (HP:0011035) | 2.53820811 |
| 23 | Hypoglycemic coma (HP:0001325) | 2.52894486 |
| 24 | Abnormality of methionine metabolism (HP:0010901) | 2.51489627 |
| 25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.50967755 |
| 26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.50967755 |
| 27 | Abnormality of midbrain morphology (HP:0002418) | 2.49821926 |
| 28 | Molar tooth sign on MRI (HP:0002419) | 2.49821926 |
| 29 | Lactic acidosis (HP:0003128) | 2.48295732 |
| 30 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.46119346 |
| 31 | Abnormality of alanine metabolism (HP:0010916) | 2.46119346 |
| 32 | Hyperalaninemia (HP:0003348) | 2.46119346 |
| 33 | Nephronophthisis (HP:0000090) | 2.44414548 |
| 34 | Abnormality of vitamin B metabolism (HP:0004340) | 2.42674976 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.42623261 |
| 36 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.40211136 |
| 37 | Renal cortical cysts (HP:0000803) | 2.39004523 |
| 38 | Abnormal protein glycosylation (HP:0012346) | 2.35926774 |
| 39 | Abnormal glycosylation (HP:0012345) | 2.35926774 |
| 40 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.35926774 |
| 41 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.35926774 |
| 42 | Respiratory failure (HP:0002878) | 2.28518620 |
| 43 | Abnormality of chromosome stability (HP:0003220) | 2.27230629 |
| 44 | Exertional dyspnea (HP:0002875) | 2.25721913 |
| 45 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.21941169 |
| 46 | Abnormality of the renal medulla (HP:0100957) | 2.19030041 |
| 47 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.18465330 |
| 48 | Abnormality of the labia minora (HP:0012880) | 2.18463944 |
| 49 | Abnormality of serum amino acid levels (HP:0003112) | 2.18035715 |
| 50 | Abolished electroretinogram (ERG) (HP:0000550) | 2.17924579 |
| 51 | Congenital, generalized hypertrichosis (HP:0004540) | 2.17837340 |
| 52 | Optic disc pallor (HP:0000543) | 2.16473359 |
| 53 | Lethargy (HP:0001254) | 2.13315232 |
| 54 | Type I transferrin isoform profile (HP:0003642) | 2.12962428 |
| 55 | Glycosuria (HP:0003076) | 2.08910306 |
| 56 | Abnormality of urine glucose concentration (HP:0011016) | 2.08910306 |
| 57 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08712660 |
| 58 | Hypoglycemic seizures (HP:0002173) | 2.08651408 |
| 59 | Meckel diverticulum (HP:0002245) | 2.06061344 |
| 60 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.04546120 |
| 61 | Ketoacidosis (HP:0001993) | 2.03172154 |
| 62 | Intestinal atresia (HP:0011100) | 2.00934196 |
| 63 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.00521461 |
| 64 | Congenital primary aphakia (HP:0007707) | 2.00156823 |
| 65 | Colon cancer (HP:0003003) | 1.99750328 |
| 66 | Abnormality of the ileum (HP:0001549) | 1.97924337 |
| 67 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.97533937 |
| 68 | Hyperglycinemia (HP:0002154) | 1.96968402 |
| 69 | Large for gestational age (HP:0001520) | 1.91963396 |
| 70 | CNS demyelination (HP:0007305) | 1.91173931 |
| 71 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.90989407 |
| 72 | Reduced antithrombin III activity (HP:0001976) | 1.89203426 |
| 73 | Abnormality of the preputium (HP:0100587) | 1.88524874 |
| 74 | Gait imbalance (HP:0002141) | 1.87945743 |
| 75 | Nephrogenic diabetes insipidus (HP:0009806) | 1.85923211 |
| 76 | Volvulus (HP:0002580) | 1.85749206 |
| 77 | Bile duct proliferation (HP:0001408) | 1.85730493 |
| 78 | Abnormal biliary tract physiology (HP:0012439) | 1.85730493 |
| 79 | Exercise intolerance (HP:0003546) | 1.85660484 |
| 80 | Abnormality of macular pigmentation (HP:0008002) | 1.84616957 |
| 81 | Constricted visual fields (HP:0001133) | 1.84456171 |
| 82 | Increased serum pyruvate (HP:0003542) | 1.84410843 |
| 83 | Leukodystrophy (HP:0002415) | 1.83219694 |
| 84 | Abnormality of the anterior horn cell (HP:0006802) | 1.80836359 |
| 85 | Degeneration of anterior horn cells (HP:0002398) | 1.80836359 |
| 86 | Respiratory difficulties (HP:0002880) | 1.80218594 |
| 87 | Abnormality of the pons (HP:0007361) | 1.80189304 |
| 88 | Furrowed tongue (HP:0000221) | 1.79200577 |
| 89 | Aplastic anemia (HP:0001915) | 1.77843507 |
| 90 | Abnormality of renal resorption (HP:0011038) | 1.76128220 |
| 91 | Chromsome breakage (HP:0040012) | 1.75920518 |
| 92 | Neoplasm of the adrenal gland (HP:0100631) | 1.75630107 |
| 93 | Hypomagnesemia (HP:0002917) | 1.74875806 |
| 94 | Generalized aminoaciduria (HP:0002909) | 1.74867346 |
| 95 | Microvesicular hepatic steatosis (HP:0001414) | 1.74852273 |
| 96 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.74578112 |
| 97 | Genital tract atresia (HP:0001827) | 1.71590452 |
| 98 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.70187038 |
| 99 | Dicarboxylic aciduria (HP:0003215) | 1.70187038 |
| 100 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.69590416 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 3.95359984 |
| 2 | MST4 | 3.71915333 |
| 3 | EIF2AK3 | 2.99062106 |
| 4 | MAP4K2 | 2.93178072 |
| 5 | EIF2AK1 | 2.69533669 |
| 6 | BMPR1B | 2.42702484 |
| 7 | ZAK | 2.36193436 |
| 8 | WNK3 | 2.28583465 |
| 9 | TRIM28 | 2.26729039 |
| 10 | NUAK1 | 2.19790044 |
| 11 | STK16 | 2.01238626 |
| 12 | SRPK1 | 1.99934301 |
| 13 | BUB1 | 1.93614807 |
| 14 | ACVR1B | 1.90816711 |
| 15 | MKNK2 | 1.88320786 |
| 16 | VRK2 | 1.87891012 |
| 17 | NME1 | 1.81986546 |
| 18 | MKNK1 | 1.74762016 |
| 19 | PLK4 | 1.72166720 |
| 20 | ERBB3 | 1.72148572 |
| 21 | MAP3K12 | 1.69560655 |
| 22 | PLK3 | 1.64046614 |
| 23 | GRK1 | 1.61435740 |
| 24 | PBK | 1.57934160 |
| 25 | ADRBK2 | 1.55747439 |
| 26 | VRK1 | 1.54496284 |
| 27 | TSSK6 | 1.52654704 |
| 28 | OXSR1 | 1.48207924 |
| 29 | TNIK | 1.41914284 |
| 30 | PLK2 | 1.38035848 |
| 31 | BCR | 1.29704654 |
| 32 | MAP3K4 | 1.29242693 |
| 33 | BRSK2 | 1.28927120 |
| 34 | INSRR | 1.28366407 |
| 35 | NEK1 | 1.21604370 |
| 36 | PINK1 | 1.18314247 |
| 37 | TLK1 | 1.15708613 |
| 38 | CDC7 | 1.11870401 |
| 39 | STK39 | 1.07722046 |
| 40 | CSNK1G1 | 1.01877365 |
| 41 | TXK | 1.00714618 |
| 42 | EIF2AK2 | 0.92522389 |
| 43 | WNK4 | 0.91499770 |
| 44 | CSNK1G3 | 0.91270647 |
| 45 | STK38L | 0.89467564 |
| 46 | PDK2 | 0.88552714 |
| 47 | BCKDK | 0.88481964 |
| 48 | CSNK1G2 | 0.87794246 |
| 49 | TAF1 | 0.82701156 |
| 50 | TAOK3 | 0.82540196 |
| 51 | PLK1 | 0.81389641 |
| 52 | CASK | 0.81189235 |
| 53 | TTK | 0.80229621 |
| 54 | PAK3 | 0.78349581 |
| 55 | PRKCE | 0.68867736 |
| 56 | PASK | 0.68719448 |
| 57 | STK3 | 0.68249809 |
| 58 | CSNK1A1L | 0.67615815 |
| 59 | WEE1 | 0.65083231 |
| 60 | TEC | 0.64264337 |
| 61 | MAPK13 | 0.63059440 |
| 62 | ATR | 0.62912989 |
| 63 | PHKG2 | 0.62260789 |
| 64 | PHKG1 | 0.62260789 |
| 65 | OBSCN | 0.61439308 |
| 66 | CDK19 | 0.57909715 |
| 67 | MAP2K7 | 0.57529660 |
| 68 | ATM | 0.57427377 |
| 69 | BMPR2 | 0.54664127 |
| 70 | DYRK2 | 0.52571166 |
| 71 | NLK | 0.51204293 |
| 72 | FLT3 | 0.49191651 |
| 73 | TGFBR1 | 0.48965484 |
| 74 | FGFR2 | 0.48393732 |
| 75 | CAMKK2 | 0.48210766 |
| 76 | CSNK2A1 | 0.47878613 |
| 77 | CSNK2A2 | 0.47789057 |
| 78 | IKBKB | 0.44757131 |
| 79 | RPS6KA5 | 0.44743750 |
| 80 | PRKCG | 0.43497698 |
| 81 | AURKB | 0.41901876 |
| 82 | DAPK2 | 0.40358668 |
| 83 | CDK3 | 0.40218733 |
| 84 | DAPK1 | 0.37348026 |
| 85 | PIK3CA | 0.37198767 |
| 86 | RPS6KA4 | 0.36540185 |
| 87 | CSNK1E | 0.35170239 |
| 88 | MAP2K6 | 0.34489667 |
| 89 | PIK3CG | 0.34479859 |
| 90 | MAPKAPK5 | 0.34424943 |
| 91 | TRPM7 | 0.33903427 |
| 92 | FER | 0.33588132 |
| 93 | CHEK2 | 0.32249931 |
| 94 | STK24 | 0.32242749 |
| 95 | TIE1 | 0.31984353 |
| 96 | CSNK1A1 | 0.29528123 |
| 97 | STK4 | 0.27971305 |
| 98 | DYRK3 | 0.27601554 |
| 99 | CCNB1 | 0.27529616 |
| 100 | ADRBK1 | 0.27506183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protein export_Homo sapiens_hsa03060 | 4.07774664 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.98189216 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.40714161 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.70731594 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.59913152 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.58755642 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.52127166 |
| 8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.42916945 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.38874157 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.28758224 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.20722306 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.13143860 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.09556767 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.93492782 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.88019215 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.84795673 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 1.81423635 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.72233501 |
| 19 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.71402093 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.66548289 |
| 21 | DNA replication_Homo sapiens_hsa03030 | 1.64313909 |
| 22 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.58583454 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.57294759 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.56429204 |
| 25 | RNA transport_Homo sapiens_hsa03013 | 1.55594425 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.53675817 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.52332581 |
| 28 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.50529547 |
| 29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.47440172 |
| 30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.45772135 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.41828822 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.36515225 |
| 33 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.35556767 |
| 34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.27004976 |
| 35 | Base excision repair_Homo sapiens_hsa03410 | 1.25398153 |
| 36 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.23255845 |
| 37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.22577479 |
| 38 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.11340313 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.10958130 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.03940102 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.03144067 |
| 42 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.02560075 |
| 43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.98456698 |
| 44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.97415457 |
| 45 | Peroxisome_Homo sapiens_hsa04146 | 0.95115907 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94654306 |
| 47 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.94534492 |
| 48 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.94474953 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.92923378 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.91938914 |
| 51 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.86117120 |
| 52 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.85220595 |
| 53 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.83415866 |
| 54 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.79348883 |
| 55 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.78005217 |
| 56 | Asthma_Homo sapiens_hsa05310 | 0.77676365 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.77233602 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68891350 |
| 59 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.68641172 |
| 60 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.68415104 |
| 61 | Circadian rhythm_Homo sapiens_hsa04710 | 0.66911768 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.66116101 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.63882945 |
| 64 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.63507105 |
| 65 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63004676 |
| 66 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.62534901 |
| 67 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.61725156 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59109154 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.57912882 |
| 70 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.57446234 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.57219642 |
| 72 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56819394 |
| 73 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.55697395 |
| 74 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.55061940 |
| 75 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53470992 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.50996740 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.48360879 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47207046 |
| 79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.46309589 |
| 80 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.44346138 |
| 81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42594863 |
| 82 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.42426333 |
| 83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.40478918 |
| 84 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40229207 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.38843813 |
| 86 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.38044442 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36282072 |
| 88 | Allograft rejection_Homo sapiens_hsa05330 | 0.36204300 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.35902269 |
| 90 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.32205843 |
| 91 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31251273 |
| 92 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30918985 |
| 93 | Taste transduction_Homo sapiens_hsa04742 | 0.30870335 |
| 94 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.30782917 |
| 95 | Legionellosis_Homo sapiens_hsa05134 | 0.30451659 |
| 96 | Carbon metabolism_Homo sapiens_hsa01200 | 0.29542127 |
| 97 | Nicotine addiction_Homo sapiens_hsa05033 | 0.27607318 |
| 98 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.22216774 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.22113995 |
| 100 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.21131737 |

