ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.70807632
2	protein complex biogenesis (GO:0070271)	4.52624165
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.27687129
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.25861422
5	ATP synthesis coupled proton transport (GO:0015986)	4.25861422
6	behavioral response to nicotine (GO:0035095)	4.21371931
7	mitochondrial respiratory chain complex assembly (GO:0033108)	4.19457852
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.18753858
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.18753858
10	NADH dehydrogenase complex assembly (GO:0010257)	4.18753858
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.09820914
12	platelet dense granule organization (GO:0060155)	3.92752308
13	respiratory chain complex IV assembly (GO:0008535)	3.89229980
14	cytochrome complex assembly (GO:0017004)	3.74060261
15	respiratory electron transport chain (GO:0022904)	3.66204805
16	electron transport chain (GO:0022900)	3.65950352
17	L-fucose catabolic process (GO:0042355)	3.59518513
18	fucose catabolic process (GO:0019317)	3.59518513
19	L-fucose metabolic process (GO:0042354)	3.59518513
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.45117320
21	DNA deamination (GO:0045006)	3.30793854
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.29034425
23	epithelial cilium movement (GO:0003351)	3.22616735
24	chaperone-mediated protein transport (GO:0072321)	3.21737301
25	protein neddylation (GO:0045116)	3.21208008
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.21105594
27	replication fork processing (GO:0031297)	3.19929806
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14787077
29	protein-cofactor linkage (GO:0018065)	3.13628471
30	tryptophan catabolic process (GO:0006569)	3.12874569
31	indole-containing compound catabolic process (GO:0042436)	3.12874569
32	indolalkylamine catabolic process (GO:0046218)	3.12874569
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09692608
34	DNA double-strand break processing (GO:0000729)	3.07328412
35	proteasome assembly (GO:0043248)	3.02971755
36	indolalkylamine metabolic process (GO:0006586)	3.02152195
37	piRNA metabolic process (GO:0034587)	3.01055167
38	mannosylation (GO:0097502)	2.99799640
39	signal peptide processing (GO:0006465)	2.96636537
40	termination of RNA polymerase III transcription (GO:0006386)	2.96113966
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.96113966
42	cellular ketone body metabolic process (GO:0046950)	2.94058694
43	centriole replication (GO:0007099)	2.89133661
44	neural tube formation (GO:0001841)	2.86365556
45	kidney morphogenesis (GO:0060993)	2.84715098
46	inner mitochondrial membrane organization (GO:0007007)	2.84582719
47	regulation of glucokinase activity (GO:0033131)	2.82714374
48	regulation of hexokinase activity (GO:1903299)	2.82714374
49	axoneme assembly (GO:0035082)	2.81751836
50	intraciliary transport (GO:0042073)	2.81008000
51	ketone body metabolic process (GO:1902224)	2.77106758
52	recombinational repair (GO:0000725)	2.76379240
53	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.74250179
54	double-strand break repair via homologous recombination (GO:0000724)	2.74213072
55	negative regulation of telomere maintenance (GO:0032205)	2.72810104
56	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.72145614
57	regulation of mitotic spindle checkpoint (GO:1903504)	2.72145614
58	pseudouridine synthesis (GO:0001522)	2.71658672
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.71049446
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.71049446
61	photoreceptor cell maintenance (GO:0045494)	2.70568948
62	resolution of meiotic recombination intermediates (GO:0000712)	2.68623711
63	hydrogen ion transmembrane transport (GO:1902600)	2.67651061
64	regulation of meiosis I (GO:0060631)	2.64222695
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62440493
66	kynurenine metabolic process (GO:0070189)	2.61966873
67	sequestering of actin monomers (GO:0042989)	2.61281810
68	nonmotile primary cilium assembly (GO:0035058)	2.60853703
69	tryptophan metabolic process (GO:0006568)	2.58946715
70	proton transport (GO:0015992)	2.58549260
71	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.56895479
72	regulation of translation, ncRNA-mediated (GO:0045974)	2.56895479
73	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.56895479
74	neuron fate determination (GO:0048664)	2.56366882
75	somite rostral/caudal axis specification (GO:0032525)	2.55986634
76	hydrogen transport (GO:0006818)	2.55676946
77	intracellular protein transmembrane import (GO:0044743)	2.55022256
78	response to pheromone (GO:0019236)	2.54496214
79	translational termination (GO:0006415)	2.54381176
80	spliceosomal complex assembly (GO:0000245)	2.53815496
81	protein prenylation (GO:0018342)	2.53178137
82	prenylation (GO:0097354)	2.53178137
83	histone mRNA metabolic process (GO:0008334)	2.53042008
84	synapsis (GO:0007129)	2.52854570
85	otic vesicle formation (GO:0030916)	2.52743732
86	anterograde synaptic vesicle transport (GO:0048490)	2.52633321
87	cilium movement (GO:0003341)	2.51320418
88	ribosomal small subunit assembly (GO:0000028)	2.51127524
89	detection of light stimulus involved in visual perception (GO:0050908)	2.49719887
90	detection of light stimulus involved in sensory perception (GO:0050962)	2.49719887
91	reciprocal meiotic recombination (GO:0007131)	2.49541298
92	reciprocal DNA recombination (GO:0035825)	2.49541298
93	ATP biosynthetic process (GO:0006754)	2.49247970
94	reflex (GO:0060004)	2.48626410
95	dopamine transport (GO:0015872)	2.48061225
96	chromatin remodeling at centromere (GO:0031055)	2.48059321
97	cotranslational protein targeting to membrane (GO:0006613)	2.45314282
98	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.43813106
99	viral transcription (GO:0019083)	2.43810050
100	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.42840346

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27628345
2	VDR_22108803_ChIP-Seq_LS180_Human	3.19023031
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.08876545
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01040496
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.85366647
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68299185
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.67792157
8	FUS_26573619_Chip-Seq_HEK293_Human	2.52779860
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45565749
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.44711119
11	EWS_26573619_Chip-Seq_HEK293_Human	2.37882161
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36862345
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31247439
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29676567
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28580323
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.15553744
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.10059715
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08795847
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08198136
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.07303685
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.06708654
22	P300_19829295_ChIP-Seq_ESCs_Human	2.05828622
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01983278
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94242718
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.93436537
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82855270
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.78667435
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.72168109
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68967816
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.67043567
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61096343
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57935006
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57544203
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49878695
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.48500880
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.47088413
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45216398
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.43775767
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43559376
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40529771
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39905761
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39382413
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37898317
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36597479
45	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.35710956
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35643936
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32926844
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32926844
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32891655
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32478555
51	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32196319
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.31738408
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31738408
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31038895
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31038895
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30198625
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29500473
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28292639
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28251158
60	AR_25329375_ChIP-Seq_VCAP_Human	1.27259920
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27131068
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25251256
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24100077
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23837288
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23837288
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23572591
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23407493
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23189098
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.21537742
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20939057
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20327290
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20023913
73	STAT3_23295773_ChIP-Seq_U87_Human	1.19549965
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18988493
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18535347
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.17306400
77	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16827608
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16205496
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.15935622
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15521802
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12765777
82	TCF4_23295773_ChIP-Seq_U87_Human	1.11918082
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11432153
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10266712
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08615731
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08457332
87	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07934580
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07901441
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06944845
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04979412
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04961118
92	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04544771
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02724635
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02540652
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02132197
96	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01445251
97	AR_20517297_ChIP-Seq_VCAP_Human	1.00892798
98	NCOR_22424771_ChIP-Seq_293T_Human	0.99893500
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98628204
100	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.97841700

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.87055987
2	MP0006292_abnormal_olfactory_placode	2.81877433
3	MP0003136_yellow_coat_color	2.73367661
4	MP0002638_abnormal_pupillary_reflex	2.50036227
5	MP0002102_abnormal_ear_morphology	2.46310253
6	MP0000372_irregular_coat_pigmentation	2.43452326
7	MP0006072_abnormal_retinal_apoptosis	2.38238134
8	MP0009379_abnormal_foot_pigmentation	2.29206989
9	MP0002938_white_spotting	2.28741580
10	MP0000569_abnormal_digit_pigmentation	2.25551349
11	MP0003195_calcinosis	2.25455137
12	MP0005551_abnormal_eye_electrophysiolog	2.18022107
13	MP0003011_delayed_dark_adaptation	2.17344247
14	MP0002837_dystrophic_cardiac_calcinosis	2.11672555
15	MP0008058_abnormal_DNA_repair	2.08831057
16	MP0005084_abnormal_gallbladder_morpholo	2.01753624
17	MP0003880_abnormal_central_pattern	2.00865067
18	MP0001968_abnormal_touch/_nociception	1.90027651
19	MP0002736_abnormal_nociception_after	1.89229022
20	MP0005253_abnormal_eye_physiology	1.81796128
21	MP0004142_abnormal_muscle_tone	1.78514002
22	MP0005174_abnormal_tail_pigmentation	1.71891704
23	MP0003787_abnormal_imprinting	1.71307586
24	MP0001529_abnormal_vocalization	1.66561283
25	MP0001485_abnormal_pinna_reflex	1.60843577
26	MP0008995_early_reproductive_senescence	1.56881277
27	MP0002277_abnormal_respiratory_mucosa	1.56739644
28	MP0009046_muscle_twitch	1.55373691
29	MP0008872_abnormal_physiological_respon	1.51934132
30	MP0005075_abnormal_melanosome_morpholog	1.50193719
31	MP0009745_abnormal_behavioral_response	1.48931778
32	MP0000631_abnormal_neuroendocrine_gland	1.48166462
33	MP0008057_abnormal_DNA_replication	1.46654038
34	MP0005645_abnormal_hypothalamus_physiol	1.45788420
35	MP0008875_abnormal_xenobiotic_pharmacok	1.45786460
36	MP0003718_maternal_effect	1.45101207
37	MP0002095_abnormal_skin_pigmentation	1.43565005
38	MP0005646_abnormal_pituitary_gland	1.42565760
39	MP0002928_abnormal_bile_duct	1.41445266
40	MP0003121_genomic_imprinting	1.38497688
41	MP0006276_abnormal_autonomic_nervous	1.37650112
42	MP0002272_abnormal_nervous_system	1.37326226
43	MP0010386_abnormal_urinary_bladder	1.31685215
44	MP0004885_abnormal_endolymph	1.28604191
45	MP0004147_increased_porphyrin_level	1.28468103
46	MP0001986_abnormal_taste_sensitivity	1.28145436
47	MP0001293_anophthalmia	1.28029391
48	MP0003890_abnormal_embryonic-extraembry	1.27485758
49	MP0001486_abnormal_startle_reflex	1.26673742
50	MP0001984_abnormal_olfaction	1.25742919
51	MP0002234_abnormal_pharynx_morphology	1.25637394
52	MP0004742_abnormal_vestibular_system	1.24803006
53	MP0001905_abnormal_dopamine_level	1.24468435
54	MP0004133_heterotaxia	1.23696713
55	MP0002653_abnormal_ependyma_morphology	1.23006549
56	MP0002735_abnormal_chemical_nociception	1.22636235
57	MP0003122_maternal_imprinting	1.18345290
58	MP0000427_abnormal_hair_cycle	1.12882196
59	MP0002751_abnormal_autonomic_nervous	1.11855454
60	MP0002876_abnormal_thyroid_physiology	1.05159869
61	MP0002160_abnormal_reproductive_system	1.05124679
62	MP0005085_abnormal_gallbladder_physiolo	1.03981631
63	MP0001764_abnormal_homeostasis	1.03189122
64	MP0010094_abnormal_chromosome_stability	1.03161214
65	MP0001501_abnormal_sleep_pattern	1.02620878
66	MP0005379_endocrine/exocrine_gland_phen	1.02482868
67	MP0002557_abnormal_social/conspecific_i	1.00471621
68	MP0008789_abnormal_olfactory_epithelium	0.98963341
69	MP0002572_abnormal_emotion/affect_behav	0.98301416
70	MP0005195_abnormal_posterior_eye	0.98181436
71	MP0002067_abnormal_sensory_capabilities	0.97901806
72	MP0004043_abnormal_pH_regulation	0.95661652
73	MP0003786_premature_aging	0.93105822
74	MP0001324_abnormal_eye_pigmentation	0.92719085
75	MP0002064_seizures	0.92625903
76	MP0005389_reproductive_system_phenotype	0.92522159
77	MP0002210_abnormal_sex_determination	0.91589834
78	MP0006036_abnormal_mitochondrial_physio	0.90386581
79	MP0003186_abnormal_redox_activity	0.89476994
80	MP0005408_hypopigmentation	0.86771510
81	MP0003283_abnormal_digestive_organ	0.86434622
82	MP0000778_abnormal_nervous_system	0.85785345
83	MP0005377_hearing/vestibular/ear_phenot	0.84943415
84	MP0003878_abnormal_ear_physiology	0.84943415
85	MP0005391_vision/eye_phenotype	0.84620733
86	MP0001929_abnormal_gametogenesis	0.84103969
87	MP0002163_abnormal_gland_morphology	0.83559059
88	MP0005386_behavior/neurological_phenoty	0.83394860
89	MP0004924_abnormal_behavior	0.83394860
90	MP0002909_abnormal_adrenal_gland	0.83371241
91	MP0002752_abnormal_somatic_nervous	0.82210399
92	MP0000653_abnormal_sex_gland	0.80691925
93	MP0001970_abnormal_pain_threshold	0.79808060
94	MP0000015_abnormal_ear_pigmentation	0.79396627
95	MP0006035_abnormal_mitochondrial_morpho	0.79341377
96	MP0003698_abnormal_male_reproductive	0.77811623
97	MP0003252_abnormal_bile_duct	0.77642485
98	MP0000026_abnormal_inner_ear	0.77355673
99	MP0001188_hyperpigmentation	0.76160809
100	MP0002184_abnormal_innervation	0.76026997

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.24033182
2	Pancreatic fibrosis (HP:0100732)	3.86784614
3	True hermaphroditism (HP:0010459)	3.74115341
4	Acute necrotizing encephalopathy (HP:0006965)	3.66331362
5	Mitochondrial inheritance (HP:0001427)	3.51957433
6	Nephronophthisis (HP:0000090)	3.41246437
7	Abnormality of midbrain morphology (HP:0002418)	3.40637401
8	Molar tooth sign on MRI (HP:0002419)	3.40637401
9	Increased CSF lactate (HP:0002490)	3.34343726
10	Progressive macrocephaly (HP:0004481)	3.30582670
11	Acute encephalopathy (HP:0006846)	3.27478174
12	Increased hepatocellular lipid droplets (HP:0006565)	3.14638682
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12006328
14	Congenital stationary night blindness (HP:0007642)	3.10791691
15	Congenital, generalized hypertrichosis (HP:0004540)	2.98015274
16	Lipid accumulation in hepatocytes (HP:0006561)	2.97928096
17	Medial flaring of the eyebrow (HP:0010747)	2.95723657
18	Abnormality of the renal medulla (HP:0100957)	2.93105175
19	Hepatocellular necrosis (HP:0001404)	2.89964874
20	Abnormality of the renal cortex (HP:0011035)	2.83815646
21	Hepatic necrosis (HP:0002605)	2.70559773
22	3-Methylglutaconic aciduria (HP:0003535)	2.50658806
23	Methylmalonic acidemia (HP:0002912)	2.46855519
24	Cystic liver disease (HP:0006706)	2.43554873
25	Abolished electroretinogram (ERG) (HP:0000550)	2.41438771
26	Septo-optic dysplasia (HP:0100842)	2.39330318
27	Sclerocornea (HP:0000647)	2.35831948
28	Chronic hepatic failure (HP:0100626)	2.34985819
29	Type II lissencephaly (HP:0007260)	2.34959842
30	Renal Fanconi syndrome (HP:0001994)	2.32031841
31	Hypothermia (HP:0002045)	2.30116196
32	Renal cortical cysts (HP:0000803)	2.24689427
33	Cerebral edema (HP:0002181)	2.24103640
34	Intestinal atresia (HP:0011100)	2.23271222
35	Abnormality of the labia minora (HP:0012880)	2.23052390
36	Hyperglycinemia (HP:0002154)	2.20922952
37	Abnormal number of erythroid precursors (HP:0012131)	2.20564750
38	Attenuation of retinal blood vessels (HP:0007843)	2.20103710
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.19914075
40	Optic disc pallor (HP:0000543)	2.18585834
41	Abnormal biliary tract physiology (HP:0012439)	2.18324262
42	Bile duct proliferation (HP:0001408)	2.18324262
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17962894
44	Gait imbalance (HP:0002141)	2.17737491
45	Concave nail (HP:0001598)	2.14286809
46	Congenital primary aphakia (HP:0007707)	2.14173827
47	Colon cancer (HP:0003003)	2.13185790
48	Male pseudohermaphroditism (HP:0000037)	2.12108928
49	Methylmalonic aciduria (HP:0012120)	2.11048819
50	Tubular atrophy (HP:0000092)	2.05528910
51	Optic nerve hypoplasia (HP:0000609)	2.04651504
52	Congenital hepatic fibrosis (HP:0002612)	2.02129669
53	Volvulus (HP:0002580)	2.01958115
54	Anencephaly (HP:0002323)	2.01063165
55	Increased serum lactate (HP:0002151)	2.00120405
56	Hyperventilation (HP:0002883)	1.99784232
57	Polydipsia (HP:0001959)	1.98868930
58	Abnormal drinking behavior (HP:0030082)	1.98868930
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.97287894
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97038488
61	Genital tract atresia (HP:0001827)	1.95645253
62	Large for gestational age (HP:0001520)	1.95314046
63	Nephrogenic diabetes insipidus (HP:0009806)	1.94267729
64	Pendular nystagmus (HP:0012043)	1.94019865
65	Reticulocytopenia (HP:0001896)	1.93971580
66	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93171807
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91977584
68	Decreased central vision (HP:0007663)	1.91414243
69	Abnormality of the pons (HP:0007361)	1.91247498
70	Exertional dyspnea (HP:0002875)	1.90213647
71	Lactic acidosis (HP:0003128)	1.89660248
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88777255
73	Furrowed tongue (HP:0000221)	1.88335041
74	Abnormality of the ileum (HP:0001549)	1.87213237
75	Gastrointestinal atresia (HP:0002589)	1.86852471
76	Vaginal atresia (HP:0000148)	1.85976415
77	Meckel diverticulum (HP:0002245)	1.85787586
78	Abnormality of renal resorption (HP:0011038)	1.81418348
79	Hypoplasia of the pons (HP:0012110)	1.81165960
80	Respiratory failure (HP:0002878)	1.80860939
81	Gaze-evoked nystagmus (HP:0000640)	1.80648365
82	Glycosuria (HP:0003076)	1.79980508
83	Abnormality of urine glucose concentration (HP:0011016)	1.79980508
84	Postaxial foot polydactyly (HP:0001830)	1.79816543
85	Progressive inability to walk (HP:0002505)	1.79504676
86	Cerebellar dysplasia (HP:0007033)	1.77492234
87	Absent thumb (HP:0009777)	1.76012220
88	Postaxial hand polydactyly (HP:0001162)	1.74533155
89	Inability to walk (HP:0002540)	1.73059049
90	Lethargy (HP:0001254)	1.72869717
91	Absent/shortened dynein arms (HP:0200106)	1.72403549
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72403549
93	Increased intramyocellular lipid droplets (HP:0012240)	1.70900702
94	Abnormal ciliary motility (HP:0012262)	1.69900465
95	Supernumerary spleens (HP:0009799)	1.68829568
96	Broad-based gait (HP:0002136)	1.67783452
97	Abnormality of chromosome stability (HP:0003220)	1.66367746
98	Abnormality of vitamin B metabolism (HP:0004340)	1.66191152
99	Absent septum pellucidum (HP:0001331)	1.65571524
100	Preaxial hand polydactyly (HP:0001177)	1.65472957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.85484355
2	WNK3	2.63869917
3	NUAK1	2.58863123
4	BMPR1B	2.54402811
5	MAP4K2	2.52109222
6	VRK2	2.51745412
7	TLK1	2.07473533
8	ADRBK2	2.01396812
9	ZAK	2.01015233
10	CASK	1.88493331
11	GRK1	1.87508575
12	TNIK	1.80755664
13	INSRR	1.76484140
14	MKNK2	1.74447892
15	ACVR1B	1.73254235
16	EIF2AK3	1.69028841
17	MST4	1.68174893
18	NME1	1.67503576
19	PNCK	1.65358169
20	VRK1	1.65356957
21	PINK1	1.60147086
22	TAOK3	1.51060625
23	MAPK13	1.50914634
24	STK16	1.50766150
25	OXSR1	1.50074128
26	CDC7	1.46657651
27	MAP3K4	1.39557652
28	FGFR2	1.34860083
29	DYRK2	1.27512794
30	MKNK1	1.23337621
31	WNK4	1.21833465
32	PAK3	1.21548595
33	STK39	1.20205501
34	WEE1	1.18789411
35	BRSK2	1.17206586
36	PLK3	1.16742696
37	TAF1	1.15451838
38	TRIM28	1.14831228
39	PLK2	1.07812185
40	CDK19	1.01733440
41	PRKCG	0.99098786
42	STK38L	0.98299021
43	SRPK1	0.95266793
44	PLK4	0.95007981
45	PIK3CA	0.91096312
46	TXK	0.87345909
47	ERBB3	0.86192711
48	BCKDK	0.85326930
49	PDK2	0.83625519
50	PASK	0.83146466
51	BUB1	0.81659145
52	ADRBK1	0.81544454
53	PRKCE	0.78361631
54	STK3	0.77878821
55	MAP2K7	0.77817237
56	TGFBR1	0.77613469
57	NEK1	0.75866961
58	MARK1	0.73183163
59	MUSK	0.70578776
60	TEC	0.67123230
61	CDK3	0.66022584
62	CSNK1G2	0.65166343
63	DYRK3	0.62864960
64	BCR	0.61967219
65	TSSK6	0.61755050
66	CSNK1G1	0.61742356
67	PLK1	0.61068066
68	MAP3K12	0.59163094
69	CCNB1	0.57531397
70	ATR	0.56600392
71	RPS6KA4	0.55468707
72	EPHA4	0.55053600
73	GRK7	0.52905474
74	RPS6KA5	0.52748626
75	NTRK3	0.52300077
76	EIF2AK2	0.51982982
77	KIT	0.51650181
78	PTK2B	0.50670487
79	CSNK1G3	0.47350956
80	IKBKB	0.46493580
81	PBK	0.46477955
82	PRKCQ	0.46090845
83	PRKACA	0.43770437
84	EIF2AK1	0.43575871
85	PIK3CG	0.43492001
86	ATM	0.42389733
87	CSNK2A2	0.41891926
88	CAMKK2	0.41602274
89	DYRK1A	0.41336994
90	MAP2K6	0.41023573
91	CSNK1A1	0.40643441
92	CSNK2A1	0.40439910
93	CAMK1	0.40305591
94	CAMK2A	0.39805388
95	STK11	0.39394254
96	DAPK2	0.39224147
97	CHEK2	0.37595589
98	PRKACB	0.36631014
99	PRKG1	0.35443095
100	STK24	0.34621844

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.89453304
2	Protein export_Homo sapiens_hsa03060	3.25774491
3	Parkinsons disease_Homo sapiens_hsa05012	3.22919924
4	Ribosome_Homo sapiens_hsa03010	2.88379999
5	RNA polymerase_Homo sapiens_hsa03020	2.74248703
6	Proteasome_Homo sapiens_hsa03050	2.58512403
7	Homologous recombination_Homo sapiens_hsa03440	2.47664426
8	Huntingtons disease_Homo sapiens_hsa05016	2.31293046
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15792953
10	Alzheimers disease_Homo sapiens_hsa05010	2.11629983
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99683581
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97164003
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93007762
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.92804357
15	Butanoate metabolism_Homo sapiens_hsa00650	1.87841933
16	Phototransduction_Homo sapiens_hsa04744	1.87528203
17	Basal transcription factors_Homo sapiens_hsa03022	1.82264655
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78684120
19	Caffeine metabolism_Homo sapiens_hsa00232	1.73557824
20	RNA degradation_Homo sapiens_hsa03018	1.66874004
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66305019
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64844902
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.55553971
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53029915
25	Propanoate metabolism_Homo sapiens_hsa00640	1.52873137
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.51813938
27	Nicotine addiction_Homo sapiens_hsa05033	1.47164841
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.37559699
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37491770
30	Mismatch repair_Homo sapiens_hsa03430	1.37420606
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37419694
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36921143
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36511612
34	One carbon pool by folate_Homo sapiens_hsa00670	1.30912040
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26119655
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.23549591
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20883553
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11551265
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.11431021
40	Purine metabolism_Homo sapiens_hsa00230	1.10501929
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.09588442
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09385853
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04351356
44	Spliceosome_Homo sapiens_hsa03040	1.02954326
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02666553
46	RNA transport_Homo sapiens_hsa03013	1.01960585
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99256904
48	Peroxisome_Homo sapiens_hsa04146	0.97935313
49	Taste transduction_Homo sapiens_hsa04742	0.97729122
50	Olfactory transduction_Homo sapiens_hsa04740	0.92243418
51	Regulation of autophagy_Homo sapiens_hsa04140	0.91346097
52	Retinol metabolism_Homo sapiens_hsa00830	0.90816867
53	DNA replication_Homo sapiens_hsa03030	0.88660923
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86858508
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86828693
56	Base excision repair_Homo sapiens_hsa03410	0.83458150
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79084913
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78731177
59	Metabolic pathways_Homo sapiens_hsa01100	0.76260238
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75017874
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.72862586
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70382648
63	Glutathione metabolism_Homo sapiens_hsa00480	0.63202238
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62920552
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60721630
66	Asthma_Homo sapiens_hsa05310	0.58442903
67	Serotonergic synapse_Homo sapiens_hsa04726	0.58348692
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58106321
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58010412
70	Folate biosynthesis_Homo sapiens_hsa00790	0.57748133
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55741745
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54347973
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52537976
74	Morphine addiction_Homo sapiens_hsa05032	0.51577197
75	Fatty acid elongation_Homo sapiens_hsa00062	0.48983308
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.48559706
77	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.47429771
78	Sulfur metabolism_Homo sapiens_hsa00920	0.47224241
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46992605
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.45693220
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.45049884
82	Insulin secretion_Homo sapiens_hsa04911	0.45034661
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44810389
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.44191223
85	ABC transporters_Homo sapiens_hsa02010	0.40470728
86	Circadian entrainment_Homo sapiens_hsa04713	0.40442039
87	GABAergic synapse_Homo sapiens_hsa04727	0.38218927
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37923433
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36539953
90	Fatty acid degradation_Homo sapiens_hsa00071	0.35629105
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35210666
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32104179
93	Circadian rhythm_Homo sapiens_hsa04710	0.32054981
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31374406
95	Mineral absorption_Homo sapiens_hsa04978	0.27951778
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.27152310
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26820612
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.25906710
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25597326
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24664950

CBWD7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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