ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.83810610
2	rRNA catabolic process (GO:0016075)	5.94232074
3	viral transcription (GO:0019083)	5.64991249
4	translational termination (GO:0006415)	5.39368830
5	nucleobase catabolic process (GO:0046113)	5.34285422
6	tachykinin receptor signaling pathway (GO:0007217)	5.32897850
7	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.25374881
8	mitochondrion transport along microtubule (GO:0047497)	5.25374881
9	establishment of mitochondrion localization (GO:0051654)	5.25205720
10	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	5.21022226
11	behavioral response to nicotine (GO:0035095)	4.69003896
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.59333953
13	cotranslational protein targeting to membrane (GO:0006613)	4.56706753
14	negative regulation of DNA-templated transcription, elongation (GO:0032785)	4.54071618
15	protein targeting to ER (GO:0045047)	4.49475942
16	translational elongation (GO:0006414)	4.44254518
17	ncRNA catabolic process (GO:0034661)	4.38750429
18	hypothalamus development (GO:0021854)	4.36571696
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.35181018
20	forebrain neuron differentiation (GO:0021879)	4.30887383
21	protein localization to endoplasmic reticulum (GO:0070972)	4.22744463
22	alanine transport (GO:0032328)	4.21195370
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.14190680
24	cellular protein complex disassembly (GO:0043624)	4.04967476
25	viral life cycle (GO:0019058)	3.86118567
26	anterograde synaptic vesicle transport (GO:0048490)	3.83384719
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.82890290
28	positive regulation of growth hormone secretion (GO:0060124)	3.82716449
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.81300157
30	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.74905872
31	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.72610236
32	regulation of cilium movement (GO:0003352)	3.69809565
33	spinal cord association neuron differentiation (GO:0021527)	3.69678624
34	tongue development (GO:0043586)	3.66840698
35	ribosomal small subunit assembly (GO:0000028)	3.64500318
36	regulation of microtubule-based movement (GO:0060632)	3.55022753
37	ribosomal small subunit biogenesis (GO:0042274)	3.49379380
38	protein complex disassembly (GO:0043241)	3.45734125
39	genetic imprinting (GO:0071514)	3.41531481
40	translational initiation (GO:0006413)	3.40762661
41	nonmotile primary cilium assembly (GO:0035058)	3.39757854
42	body morphogenesis (GO:0010171)	3.36770834
43	microtubule severing (GO:0051013)	3.35209857
44	axonal fasciculation (GO:0007413)	3.33867180
45	synaptic transmission, cholinergic (GO:0007271)	3.30853051
46	macromolecular complex disassembly (GO:0032984)	3.30514018
47	cardiovascular system development (GO:0072358)	3.27456566
48	anterograde axon cargo transport (GO:0008089)	3.22993590
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.22839501
50	embryonic body morphogenesis (GO:0010172)	3.20432123
51	microtubule bundle formation (GO:0001578)	3.15282362
52	head development (GO:0060322)	3.14395776
53	neurofilament cytoskeleton organization (GO:0060052)	3.11506212
54	auditory behavior (GO:0031223)	3.07649919
55	L-fucose catabolic process (GO:0042355)	3.04131423
56	fucose catabolic process (GO:0019317)	3.04131423
57	L-fucose metabolic process (GO:0042354)	3.04131423
58	regulation of protein kinase A signaling (GO:0010738)	3.03530905
59	protein targeting to membrane (GO:0006612)	3.03300576
60	regulation of synapse structural plasticity (GO:0051823)	3.00375036
61	protein import into peroxisome matrix (GO:0016558)	2.99086373
62	arginine catabolic process (GO:0006527)	2.98492170
63	axon cargo transport (GO:0008088)	2.91266426
64	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.91233288
65	somite development (GO:0061053)	2.86744141
66	ribosomal large subunit biogenesis (GO:0042273)	2.86720612
67	cAMP catabolic process (GO:0006198)	2.83514437
68	transmission of nerve impulse (GO:0019226)	2.80086929
69	maturation of SSU-rRNA (GO:0030490)	2.74743022
70	adult walking behavior (GO:0007628)	2.68920675
71	axon extension (GO:0048675)	2.66494065
72	regulation of growth hormone secretion (GO:0060123)	2.66078637
73	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.65803002
74	retinal ganglion cell axon guidance (GO:0031290)	2.65109816
75	epithelial cilium movement (GO:0003351)	2.63346563
76	proline transport (GO:0015824)	2.62992096
77	protein neddylation (GO:0045116)	2.61479935
78	synaptic vesicle maturation (GO:0016188)	2.60300279
79	growth hormone secretion (GO:0030252)	2.60035720
80	postsynaptic membrane organization (GO:0001941)	2.59805840
81	peristalsis (GO:0030432)	2.59259971
82	centriole replication (GO:0007099)	2.58706255
83	intraciliary transport (GO:0042073)	2.58644813
84	mechanosensory behavior (GO:0007638)	2.57426874
85	mitochondrion localization (GO:0051646)	2.55965742
86	male meiosis (GO:0007140)	2.55766999
87	pattern specification involved in kidney development (GO:0061004)	2.54781123
88	neuron recognition (GO:0008038)	2.54293788
89	motile cilium assembly (GO:0044458)	2.54251081
90	positive regulation of synapse assembly (GO:0051965)	2.54165774
91	cell proliferation in forebrain (GO:0021846)	2.53946186
92	startle response (GO:0001964)	2.53611878
93	parturition (GO:0007567)	2.53519630
94	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.53371960
95	acrosome reaction (GO:0007340)	2.53166765
96	cytoskeleton-dependent intracellular transport (GO:0030705)	2.51422712
97	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.50784475
98	negative regulation of appetite (GO:0032099)	2.50765082
99	negative regulation of response to food (GO:0032096)	2.50765082
100	translation (GO:0006412)	2.50473053

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.08387009
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.81217118
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.11388232
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.75970256
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.31421201
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.26363997
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19600842
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.16217177
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.11323311
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.05030680
11	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.03298905
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	10.1033849
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98444559
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.96456831
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.87155876
16	RNF2_27304074_Chip-Seq_NSC_Mouse	1.84704414
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83693999
18	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.77955449
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.77678218
20	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.71285054
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67079118
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.63426727
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.63256484
24	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.62046627
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62044146
26	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.60601271
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59172876
28	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57385590
29	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57385590
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.50541083
31	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.45996099
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43520493
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39799808
34	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.38030647
35	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.32918367
36	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.32155543
37	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.32003885
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31971389
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30086848
40	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.30007055
41	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.28294528
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26919375
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25901059
44	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.25292616
45	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.24599517
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22001834
47	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.18075821
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16474757
49	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.14701226
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.14470256
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.12519174
52	CTCF_27219007_Chip-Seq_Bcells_Human	1.10675885
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08941677
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08594488
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06885081
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05733611
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05163112
58	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04667880
59	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03817758
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03261549
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.02428191
62	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01986910
63	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.00733799
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00366322
65	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00034060
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95250129
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.93137315
68	IGF1R_20145208_ChIP-Seq_DFB_Human	0.93063814
69	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.92811163
70	P300_19829295_ChIP-Seq_ESCs_Human	0.91658118
71	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.91125746
72	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.88503874
73	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.86616915
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83769327
75	FUS_26573619_Chip-Seq_HEK293_Human	0.83108127
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.82639241
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81715035
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.81715035
79	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.81633993
80	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.80884517
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.79837267
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.79743356
83	GBX2_23144817_ChIP-Seq_PC3_Human	0.79059249
84	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.78341015
85	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.77699751
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.76642355
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.76170674
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.76141153
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.75569343
90	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.74922401
91	GABP_19822575_ChIP-Seq_HepG2_Human	0.73499788
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.73251382
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.73168331
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.72942293
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.70879583
96	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.70741091
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.70719508
98	NCOR_22424771_ChIP-Seq_293T_Human	0.70340558
99	SOX2_21211035_ChIP-Seq_LN229_Human	0.69910351
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.69881622

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.27107289
2	MP0003011_delayed_dark_adaptation	4.23183838
3	MP0008877_abnormal_DNA_methylation	3.28370904
4	MP0003123_paternal_imprinting	3.02866806
5	MP0003878_abnormal_ear_physiology	2.98541678
6	MP0005377_hearing/vestibular/ear_phenot	2.98541678
7	MP0003122_maternal_imprinting	2.93029604
8	MP0006276_abnormal_autonomic_nervous	2.87909366
9	MP0003121_genomic_imprinting	2.81689274
10	MP0004142_abnormal_muscle_tone	2.63316036
11	MP0003136_yellow_coat_color	2.47844737
12	MP0002822_catalepsy	2.46435815
13	MP0002638_abnormal_pupillary_reflex	2.26571441
14	MP0001188_hyperpigmentation	2.23812305
15	MP0009046_muscle_twitch	2.13292966
16	MP0001984_abnormal_olfaction	2.11438754
17	MP0005645_abnormal_hypothalamus_physiol	2.01365328
18	MP0002272_abnormal_nervous_system	2.00735997
19	MP0002733_abnormal_thermal_nociception	1.94559342
20	MP0002928_abnormal_bile_duct	1.85787630
21	MP0001970_abnormal_pain_threshold	1.84537115
22	MP0004859_abnormal_synaptic_plasticity	1.80659364
23	MP0000778_abnormal_nervous_system	1.78899526
24	MP0006292_abnormal_olfactory_placode	1.76683445
25	MP0001968_abnormal_touch/_nociception	1.71651179
26	MP0005084_abnormal_gallbladder_morpholo	1.64913048
27	MP0005551_abnormal_eye_electrophysiolog	1.64894451
28	MP0009379_abnormal_foot_pigmentation	1.59692495
29	MP0005423_abnormal_somatic_nervous	1.58861065
30	MP0002184_abnormal_innervation	1.57186089
31	MP0001440_abnormal_grooming_behavior	1.52602495
32	MP0008789_abnormal_olfactory_epithelium	1.51431938
33	MP0002138_abnormal_hepatobiliary_system	1.50348677
34	MP0002163_abnormal_gland_morphology	1.49971099
35	MP0005253_abnormal_eye_physiology	1.47850045
36	MP0005394_taste/olfaction_phenotype	1.44806973
37	MP0005499_abnormal_olfactory_system	1.44806973
38	MP0002102_abnormal_ear_morphology	1.44700008
39	MP0002557_abnormal_social/conspecific_i	1.44264372
40	MP0002063_abnormal_learning/memory/cond	1.42880210
41	MP0003635_abnormal_synaptic_transmissio	1.42831323
42	MP0001529_abnormal_vocalization	1.35687062
43	MP0003646_muscle_fatigue	1.35485787
44	MP0000955_abnormal_spinal_cord	1.34685519
45	MP0001905_abnormal_dopamine_level	1.33195639
46	MP0002572_abnormal_emotion/affect_behav	1.31273669
47	MP0002064_seizures	1.31125647
48	MP0009745_abnormal_behavioral_response	1.27816531
49	MP0002752_abnormal_somatic_nervous	1.24318644
50	MP0001485_abnormal_pinna_reflex	1.23801105
51	MP0002876_abnormal_thyroid_physiology	1.23397858
52	MP0002735_abnormal_chemical_nociception	1.23331590
53	MP0005646_abnormal_pituitary_gland	1.22820986
54	MP0001486_abnormal_startle_reflex	1.21328652
55	MP0004924_abnormal_behavior	1.19604739
56	MP0005386_behavior/neurological_phenoty	1.19604739
57	MP0003890_abnormal_embryonic-extraembry	1.17307328
58	MP0002882_abnormal_neuron_morphology	1.14173230
59	MP0002734_abnormal_mechanical_nocicepti	1.13629706
60	MP0001293_anophthalmia	1.12467518
61	MP0003942_abnormal_urinary_system	1.09386079
62	MP0006072_abnormal_retinal_apoptosis	1.09030630
63	MP0005195_abnormal_posterior_eye	1.08996703
64	MP0002653_abnormal_ependyma_morphology	1.08167032
65	MP0000631_abnormal_neuroendocrine_gland	1.08006401
66	MP0003186_abnormal_redox_activity	1.07520245
67	MP0002067_abnormal_sensory_capabilities	1.06611423
68	MP0003880_abnormal_central_pattern	1.06420763
69	MP0004145_abnormal_muscle_electrophysio	1.05527448
70	MP0005409_darkened_coat_color	1.05302014
71	MP0004043_abnormal_pH_regulation	1.03606461
72	MP0009384_cardiac_valve_regurgitation	1.02281486
73	MP0002909_abnormal_adrenal_gland	1.00050886
74	MP0005187_abnormal_penis_morphology	0.98601641
75	MP0004381_abnormal_hair_follicle	0.97495115
76	MP0002160_abnormal_reproductive_system	0.95747197
77	MP0005410_abnormal_fertilization	0.95695575
78	MP0001963_abnormal_hearing_physiology	0.95678303
79	MP0003879_abnormal_hair_cell	0.93380667
80	MP0001986_abnormal_taste_sensitivity	0.92357883
81	MP0004885_abnormal_endolymph	0.89786100
82	MP0004811_abnormal_neuron_physiology	0.89746146
83	MP0000026_abnormal_inner_ear	0.87124257
84	MP0003252_abnormal_bile_duct	0.85871759
85	MP0008872_abnormal_physiological_respon	0.85683556
86	MP0002233_abnormal_nose_morphology	0.85286095
87	MP0005391_vision/eye_phenotype	0.84783544
88	MP0002736_abnormal_nociception_after	0.83576864
89	MP0005389_reproductive_system_phenotype	0.82500249
90	MP0002152_abnormal_brain_morphology	0.81458679
91	MP0000427_abnormal_hair_cycle	0.81243379
92	MP0002837_dystrophic_cardiac_calcinosis	0.81090596
93	MP0004742_abnormal_vestibular_system	0.77740879
94	MP0000534_abnormal_ureter_morphology	0.77683747
95	MP0001324_abnormal_eye_pigmentation	0.77336657
96	MP0008058_abnormal_DNA_repair	0.76686027
97	MP0000230_abnormal_systemic_arterial	0.76297641
98	MP0010386_abnormal_urinary_bladder	0.76027339
99	MP0001919_abnormal_reproductive_system	0.74764993
100	MP0005083_abnormal_biliary_tract	0.72935417

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	5.16934489
2	Oligomenorrhea (HP:0000876)	4.00995292
3	Reticulocytopenia (HP:0001896)	3.55668916
4	Hyperglycinemia (HP:0002154)	3.55644672
5	Stenosis of the external auditory canal (HP:0000402)	3.51276719
6	Hip dysplasia (HP:0001385)	3.20920601
7	Hypogonadotrophic hypogonadism (HP:0000044)	3.18807544
8	Pancreatic fibrosis (HP:0100732)	3.10087192
9	Myokymia (HP:0002411)	3.08036548
10	Medial flaring of the eyebrow (HP:0010747)	3.06937133
11	Abnormality of cells of the erythroid lineage (HP:0012130)	2.99120595
12	Conjugated hyperbilirubinemia (HP:0002908)	2.95311057
13	Polyphagia (HP:0002591)	2.93605105
14	Gait imbalance (HP:0002141)	2.92862947
15	Agitation (HP:0000713)	2.91362216
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.77053015
17	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.76627778
18	Nephrogenic diabetes insipidus (HP:0009806)	2.72622387
19	Progressive cerebellar ataxia (HP:0002073)	2.72216490
20	Entropion (HP:0000621)	2.66756369
21	Oligodactyly (HP:0012165)	2.63223904
22	Hypoplastic pelvis (HP:0008839)	2.62336256
23	Acute necrotizing encephalopathy (HP:0006965)	2.60578163
24	Oligodactyly (hands) (HP:0001180)	2.58749059
25	Impulsivity (HP:0100710)	2.56952563
26	Metaphyseal dysplasia (HP:0100255)	2.54778069
27	Macrocytic anemia (HP:0001972)	2.54776606
28	Abnormal hair whorl (HP:0010721)	2.53476900
29	Abnormal biliary tract physiology (HP:0012439)	2.52856078
30	Bile duct proliferation (HP:0001408)	2.52856078
31	Adrenal hypoplasia (HP:0000835)	2.47237384
32	Congenital primary aphakia (HP:0007707)	2.46419947
33	Supernumerary spleens (HP:0009799)	2.46164476
34	Lissencephaly (HP:0001339)	2.45717625
35	Tubular atrophy (HP:0000092)	2.44745553
36	Pendular nystagmus (HP:0012043)	2.44116786
37	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.41274195
38	Short 4th metacarpal (HP:0010044)	2.41274195
39	Abnormality of DNA repair (HP:0003254)	2.40050057
40	Abnormal drinking behavior (HP:0030082)	2.39664666
41	Polydipsia (HP:0001959)	2.39664666
42	Pachygyria (HP:0001302)	2.38961721
43	Genetic anticipation (HP:0003743)	2.37472005
44	Menstrual irregularities (HP:0000858)	2.36911888
45	Hypoplastic female external genitalia (HP:0012815)	2.34346471
46	Diastasis recti (HP:0001540)	2.33330215
47	Failure to thrive in infancy (HP:0001531)	2.26263062
48	Abnormality of the 4th metacarpal (HP:0010012)	2.25937746
49	Nephronophthisis (HP:0000090)	2.24341293
50	Pancreatic cysts (HP:0001737)	2.22686419
51	Poor suck (HP:0002033)	2.22633054
52	Cystic liver disease (HP:0006706)	2.22189011
53	Methylmalonic acidemia (HP:0002912)	2.19469181
54	Labial hypoplasia (HP:0000066)	2.18157170
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17146920
56	Abnormal mitochondria in muscle tissue (HP:0008316)	2.16023062
57	Abnormal hemoglobin (HP:0011902)	2.15348521
58	Thickened calvaria (HP:0002684)	2.13470757
59	Optic disc pallor (HP:0000543)	2.12719447
60	Asplenia (HP:0001746)	2.12257668
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.10252573
62	Clumsiness (HP:0002312)	2.07728749
63	Mitochondrial inheritance (HP:0001427)	2.06927103
64	Abnormality of the renal cortex (HP:0011035)	2.05224460
65	Tubulointerstitial abnormality (HP:0001969)	2.05223339
66	Absent/shortened dynein arms (HP:0200106)	2.03530406
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03530406
68	Progressive macrocephaly (HP:0004481)	2.02171237
69	Absent thumb (HP:0009777)	2.02123275
70	Tubulointerstitial fibrosis (HP:0005576)	2.00937957
71	Abnormality of the renal medulla (HP:0100957)	1.98405100
72	Anosmia (HP:0000458)	1.97952333
73	Type II lissencephaly (HP:0007260)	1.97764525
74	Hypoplastic iliac wings (HP:0002866)	1.96145514
75	Chronic hepatic failure (HP:0100626)	1.95557696
76	Anencephaly (HP:0002323)	1.95232184
77	Pigmentary retinal degeneration (HP:0001146)	1.95110950
78	J-shaped sella turcica (HP:0002680)	1.93026956
79	Deep palmar crease (HP:0006191)	1.92642307
80	Decreased muscle mass (HP:0003199)	1.91066451
81	Methylmalonic aciduria (HP:0012120)	1.90316163
82	Abnormality of glycine metabolism (HP:0010895)	1.89043545
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.89043545
84	Papilledema (HP:0001085)	1.88349999
85	Acute encephalopathy (HP:0006846)	1.87278095
86	Retinitis pigmentosa (HP:0000510)	1.87270039
87	Broad-based gait (HP:0002136)	1.85493013
88	Keratoconus (HP:0000563)	1.83966506
89	Increased corneal curvature (HP:0100692)	1.83966506
90	Growth hormone deficiency (HP:0000824)	1.83943458
91	Limb dystonia (HP:0002451)	1.81920624
92	Epileptic encephalopathy (HP:0200134)	1.81788024
93	Specific learning disability (HP:0001328)	1.78889191
94	Increased CSF lactate (HP:0002490)	1.78607779
95	Squamous cell carcinoma (HP:0002860)	1.77345579
96	Polyuria (HP:0000103)	1.75400770
97	Abnormality of midbrain morphology (HP:0002418)	1.74129992
98	Molar tooth sign on MRI (HP:0002419)	1.74129992
99	Abnormal eating behavior (HP:0100738)	1.73557510
100	Short femoral neck (HP:0100864)	1.73238479

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.05380535
2	MAP4K2	3.91368223
3	MARK1	2.94562984
4	DYRK2	2.93932925
5	CASK	2.88055051
6	WNK4	2.84828146
7	TXK	2.51425527
8	MAP3K11	2.16301225
9	MAP3K12	2.14786148
10	TLK1	1.97781596
11	EPHA4	1.82582302
12	TYRO3	1.75830648
13	PHKG1	1.74781043
14	PHKG2	1.74781043
15	ZAK	1.67890819
16	MAP2K4	1.67195783
17	ADRBK2	1.65537224
18	BUB1	1.57666764
19	MAP2K7	1.57216737
20	PIK3CA	1.54723555
21	PIM2	1.49831206
22	NTRK3	1.38344035
23	CDK19	1.38224697
24	MINK1	1.36402178
25	MAPK13	1.27253239
26	PASK	1.27096018
27	PNCK	1.26923922
28	BCR	1.25810528
29	TRIM28	1.25112877
30	LRRK2	1.20944984
31	GRK1	1.20682779
32	DAPK3	1.19040554
33	MAP3K13	1.16700442
34	NTRK2	1.14287965
35	PRKCH	1.09938846
36	SGK1	1.06826868
37	STK39	1.05838541
38	BCKDK	1.03569486
39	CSNK1G2	1.03560475
40	DYRK1B	1.00212211
41	PRKCG	0.98116672
42	NEK1	0.93331047
43	MAP3K4	0.90729570
44	ARAF	0.88793687
45	GRK7	0.88398582
46	AURKA	0.85815101
47	PRKCQ	0.85296584
48	SGK223	0.83516073
49	SGK494	0.83516073
50	CSNK1E	0.82105736
51	WNK1	0.81963623
52	BRAF	0.81087370
53	NUAK1	0.80693025
54	EPHB2	0.79867460
55	TAOK3	0.77857023
56	PRKCZ	0.77593306
57	DMPK	0.77557079
58	CSNK1G3	0.76383925
59	RAF1	0.73757272
60	CSNK1A1L	0.69298019
61	CAMKK1	0.68280066
62	OXSR1	0.67722871
63	PLK1	0.67258226
64	MAP3K7	0.65617175
65	CDC7	0.63380289
66	NEK2	0.61249863
67	GRK5	0.59597455
68	PRKACA	0.59300402
69	PRKCI	0.55613798
70	BMPR1B	0.55391000
71	ADRBK1	0.55016707
72	LIMK1	0.52903729
73	PRKG1	0.50364038
74	WNK3	0.49069444
75	CDK5	0.49057645
76	DYRK3	0.48764861
77	CSNK1G1	0.48492678
78	STK11	0.46817443
79	DYRK1A	0.46787976
80	MAPK12	0.45612261
81	AURKB	0.45058579
82	PRKDC	0.42478997
83	FRK	0.41224750
84	RPS6KA6	0.39486453
85	MAP3K2	0.39112603
86	CAMK1G	0.38749604
87	CAMK1	0.38702522
88	MAPK7	0.37477814
89	UHMK1	0.35772243
90	SIK2	0.34727410
91	INSRR	0.34482008
92	FLT3	0.34375275
93	PIM1	0.33277310
94	MAPK9	0.33256916
95	RPS6KA3	0.33181002
96	AKT1	0.33144003
97	MAPK8	0.32974411
98	BTK	0.32852076
99	ROCK1	0.31636862
100	CDK14	0.29897004

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.44550145
2	Parkinsons disease_Homo sapiens_hsa05012	3.22506546
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.21409813
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.17009571
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.89247573
6	Basal transcription factors_Homo sapiens_hsa03022	2.67501275
7	Protein export_Homo sapiens_hsa03060	2.61662112
8	Nicotine addiction_Homo sapiens_hsa05033	2.40666953
9	Butanoate metabolism_Homo sapiens_hsa00650	2.38287442
10	Alzheimers disease_Homo sapiens_hsa05010	2.08648590
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.07768120
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05923279
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.95282042
14	Huntingtons disease_Homo sapiens_hsa05016	1.95223312
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.83998145
16	Morphine addiction_Homo sapiens_hsa05032	1.68923644
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.68428008
18	Basal cell carcinoma_Homo sapiens_hsa05217	1.54693624
19	RNA polymerase_Homo sapiens_hsa03020	1.54363408
20	Phototransduction_Homo sapiens_hsa04744	1.53761325
21	Homologous recombination_Homo sapiens_hsa03440	1.49734245
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.47814288
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45502077
24	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.45295357
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43091326
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34217846
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.33221266
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30770825
29	Alcoholism_Homo sapiens_hsa05034	1.29924124
30	Olfactory transduction_Homo sapiens_hsa04740	1.21857414
31	RNA degradation_Homo sapiens_hsa03018	1.21353474
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20926689
33	GABAergic synapse_Homo sapiens_hsa04727	1.17183461
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.12594715
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09587277
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.06560229
37	One carbon pool by folate_Homo sapiens_hsa00670	1.06477720
38	Insulin secretion_Homo sapiens_hsa04911	1.05452923
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.03293050
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03178737
41	Serotonergic synapse_Homo sapiens_hsa04726	1.03165000
42	Taste transduction_Homo sapiens_hsa04742	0.98666248
43	Axon guidance_Homo sapiens_hsa04360	0.94063299
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93136090
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91456975
46	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.91342472
47	Dopaminergic synapse_Homo sapiens_hsa04728	0.90460247
48	Circadian entrainment_Homo sapiens_hsa04713	0.88745396
49	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.87790355
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87170227
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.82941478
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75537511
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.75288471
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73617548
55	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.73010987
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.72967802
57	Notch signaling pathway_Homo sapiens_hsa04330	0.72889758
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.71482793
59	Propanoate metabolism_Homo sapiens_hsa00640	0.70625706
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70047634
61	Gap junction_Homo sapiens_hsa04540	0.67338430
62	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.64904779
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.63607091
64	Cholinergic synapse_Homo sapiens_hsa04725	0.63407262
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62647606
66	Long-term depression_Homo sapiens_hsa04730	0.61357975
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60495360
68	Retinol metabolism_Homo sapiens_hsa00830	0.60446127
69	Melanogenesis_Homo sapiens_hsa04916	0.59572801
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59261660
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57436686
72	Peroxisome_Homo sapiens_hsa04146	0.57037290
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.56145015
74	Salivary secretion_Homo sapiens_hsa04970	0.55799749
75	Cocaine addiction_Homo sapiens_hsa05030	0.54997294
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52116525
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.50360132
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47962866
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.46452012
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.40777283
81	GnRH signaling pathway_Homo sapiens_hsa04912	0.40544874
82	Bile secretion_Homo sapiens_hsa04976	0.40089533
83	Metabolic pathways_Homo sapiens_hsa01100	0.39675261
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39621128
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.39503022
86	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39464288
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.37586775
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.36016494
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35132828
90	Proteasome_Homo sapiens_hsa03050	0.35037457
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34955306
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33884067
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31687404
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31390398
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30320174
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.28169740
97	Amphetamine addiction_Homo sapiens_hsa05031	0.27847148
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27414479
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26014941
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.25834358

CBX1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »