CBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.53538050
2protein localization to kinetochore (GO:0034501)4.70285828
3pre-miRNA processing (GO:0031054)4.50756750
4mitotic chromosome condensation (GO:0007076)4.20596612
5paraxial mesoderm development (GO:0048339)4.14999487
6protein localization to chromosome, centromeric region (GO:0071459)4.06643604
7regulation of sister chromatid cohesion (GO:0007063)4.06372543
8DNA replication-dependent nucleosome assembly (GO:0006335)4.05281190
9DNA replication-dependent nucleosome organization (GO:0034723)4.05281190
10DNA replication initiation (GO:0006270)4.04520704
11DNA strand elongation involved in DNA replication (GO:0006271)4.00322291
12nuclear pore organization (GO:0006999)3.92920727
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.90946857
14nuclear pore complex assembly (GO:0051292)3.89514459
15mitotic metaphase plate congression (GO:0007080)3.87604016
16mitotic nuclear envelope disassembly (GO:0007077)3.87426555
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82289725
18DNA strand elongation (GO:0022616)3.80833658
19heterochromatin organization (GO:0070828)3.75139734
20mitotic sister chromatid cohesion (GO:0007064)3.71553930
21sister chromatid segregation (GO:0000819)3.66761109
22mitotic sister chromatid segregation (GO:0000070)3.66267390
23DNA topological change (GO:0006265)3.63687184
24dosage compensation (GO:0007549)3.63185336
25membrane disassembly (GO:0030397)3.60466199
26nuclear envelope disassembly (GO:0051081)3.60466199
27negative regulation of histone methylation (GO:0031061)3.57636844
28negative regulation of RNA splicing (GO:0033119)3.55609231
29L-serine metabolic process (GO:0006563)3.55607753
30protein localization to chromosome (GO:0034502)3.55215648
31ribosomal small subunit biogenesis (GO:0042274)3.48966644
32metaphase plate congression (GO:0051310)3.47420794
33telomere maintenance via semi-conservative replication (GO:0032201)3.42778123
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42181807
35folic acid-containing compound biosynthetic process (GO:0009396)3.41957636
36ribosomal small subunit assembly (GO:0000028)3.41822772
37maturation of SSU-rRNA (GO:0030490)3.41187134
38protein-DNA complex disassembly (GO:0032986)3.40353469
39nucleosome disassembly (GO:0006337)3.40353469
40protein complex localization (GO:0031503)3.36130285
41viral transcription (GO:0019083)3.35755752
42negative regulation of mRNA processing (GO:0050686)3.34503223
43DNA replication checkpoint (GO:0000076)3.34436791
44DNA duplex unwinding (GO:0032508)3.34350089
45DNA geometric change (GO:0032392)3.34006236
46regulation of histone H3-K9 methylation (GO:0051570)3.32220775
47positive regulation of chromosome segregation (GO:0051984)3.29902078
48chromatin assembly (GO:0031497)3.29406376
49kinetochore organization (GO:0051383)3.28082292
50translational termination (GO:0006415)3.27147558
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25644777
52chromatin assembly or disassembly (GO:0006333)3.25242292
53DNA ligation (GO:0006266)3.23394531
54mitotic recombination (GO:0006312)3.21785799
55regulation of translational fidelity (GO:0006450)3.20892650
56attachment of spindle microtubules to kinetochore (GO:0008608)3.20313798
57ATP-dependent chromatin remodeling (GO:0043044)3.18625851
58regulation of chromosome segregation (GO:0051983)3.17340032
59telomere maintenance via recombination (GO:0000722)3.15796942
60peptidyl-arginine omega-N-methylation (GO:0035247)3.12941295
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11566978
62negative regulation of chromosome segregation (GO:0051985)3.11512233
63regulation of gene silencing by miRNA (GO:0060964)3.11280471
64regulation of gene silencing by RNA (GO:0060966)3.11280471
65regulation of posttranscriptional gene silencing (GO:0060147)3.11280471
66histone arginine methylation (GO:0034969)3.10845392
67DNA replication-independent nucleosome organization (GO:0034724)3.09947975
68DNA replication-independent nucleosome assembly (GO:0006336)3.09947975
69regulation of spindle organization (GO:0090224)3.07140107
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04842579
71formation of translation preinitiation complex (GO:0001731)3.03824895
72histone H2A monoubiquitination (GO:0035518)3.03799132
73planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03635826
74regulation of centriole replication (GO:0046599)3.02605732
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02307151
76negative regulation of sister chromatid segregation (GO:0033046)3.02307151
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.02307151
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02307151
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01812018
80convergent extension (GO:0060026)3.01450544
81mitotic spindle assembly checkpoint (GO:0007094)2.99991290
82spindle assembly checkpoint (GO:0071173)2.99617055
83spindle checkpoint (GO:0031577)2.98189974
84translesion synthesis (GO:0019985)2.98109466
85pore complex assembly (GO:0046931)2.96438063
86chromatin remodeling at centromere (GO:0031055)2.95609334
87kinetochore assembly (GO:0051382)2.95271043
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.94768602
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94768602
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94768602
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94478780
92regulation of helicase activity (GO:0051095)2.94021408
93regulation of chromatin binding (GO:0035561)2.93910997
94telomere maintenance via telomere lengthening (GO:0010833)2.93529676
95mitotic spindle checkpoint (GO:0071174)2.92375728
96establishment of integrated proviral latency (GO:0075713)2.92198494
97establishment of chromosome localization (GO:0051303)2.92192124
98negative regulation of mRNA metabolic process (GO:1903312)2.89771210
99chromosome condensation (GO:0030261)2.88693959
100regulation of centrosome cycle (GO:0046605)2.88376691
101RNA stabilization (GO:0043489)2.87014443
102mRNA stabilization (GO:0048255)2.87014443
103CENP-A containing nucleosome assembly (GO:0034080)2.85866407
104regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85543233
105viral mRNA export from host cell nucleus (GO:0046784)2.85369802
106DNA conformation change (GO:0071103)2.84903606
107nuclear envelope organization (GO:0006998)2.84900770
108establishment of viral latency (GO:0019043)2.83614223
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.83204575
110chromosome segregation (GO:0007059)2.83017804
111translational elongation (GO:0006414)2.82938242
112positive regulation of cell cycle G2/M phase transition (GO:1902751)2.82243736
113positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.82243736
114mRNA splicing, via spliceosome (GO:0000398)2.81221875
115RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81221875
116IMP biosynthetic process (GO:0006188)2.80842408
117RNA splicing, via transesterification reactions (GO:0000375)2.80218256
118regulation of sister chromatid segregation (GO:0033045)2.79863852
119regulation of mitotic sister chromatid separation (GO:0010965)2.79863852
120regulation of mitotic sister chromatid segregation (GO:0033047)2.79863852
121DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79745676
122mismatch repair (GO:0006298)2.79399906
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.79082061
124base-excision repair (GO:0006284)2.79013940
125DNA packaging (GO:0006323)2.78452271
126DNA strand renaturation (GO:0000733)2.75021755
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74912852
128protein complex disassembly (GO:0043241)2.72129702
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.70423103
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70423103
131histone exchange (GO:0043486)2.69616855
132non-recombinational repair (GO:0000726)2.69362014
133double-strand break repair via nonhomologous end joining (GO:0006303)2.69362014
134peptidyl-arginine methylation (GO:0018216)2.68760528
135peptidyl-arginine N-methylation (GO:0035246)2.68760528
136translational initiation (GO:0006413)2.67978384
137nucleobase biosynthetic process (GO:0046112)2.64440152
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63929004
139cellular protein complex disassembly (GO:0043624)2.59883888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.73327240
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11339655
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76929074
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.72436344
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.93909893
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84160709
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.76180524
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68752629
9MYC_22102868_ChIP-Seq_BL_Human2.49330635
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47305976
11AR_21909140_ChIP-Seq_LNCAP_Human2.47214802
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.37460982
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30123046
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14478123
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14011961
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13424943
17XRN2_22483619_ChIP-Seq_HELA_Human2.10731815
18E2F7_22180533_ChIP-Seq_HELA_Human10.2177038
19CIITA_25753668_ChIP-Seq_RAJI_Human1.97798924
20MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93699904
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88715516
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76716983
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72480924
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72476585
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70598938
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.68167708
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.67927026
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67005953
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65270745
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.65097109
31TTF2_22483619_ChIP-Seq_HELA_Human1.63346859
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60714502
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59803818
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58437146
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54893483
36NANOG_21062744_ChIP-ChIP_HESCs_Human1.54173515
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51613760
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48146623
39GABP_19822575_ChIP-Seq_HepG2_Human1.47961026
40KDM5A_27292631_Chip-Seq_BREAST_Human1.47346428
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46093157
42* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45286007
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43852429
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42259477
45* SOX2_16153702_ChIP-ChIP_HESCs_Human1.42223287
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39399883
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37686693
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36997988
49FOXP3_21729870_ChIP-Seq_TREG_Human1.33224449
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32998933
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32916936
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30265550
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30066927
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29756407
55VDR_21846776_ChIP-Seq_THP-1_Human1.28648344
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28452429
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27609629
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25999453
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25810981
60VDR_23849224_ChIP-Seq_CD4+_Human1.25425040
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24999187
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.24593466
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23456850
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.23111295
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22329218
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22329218
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22329218
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22245169
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20962460
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19201096
71ZNF263_19887448_ChIP-Seq_K562_Human1.18792166
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18386581
73DCP1A_22483619_ChIP-Seq_HELA_Human1.18289901
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17727160
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14539084
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14235740
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11879315
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11794846
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.11354466
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11205158
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10867440
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09276011
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07199042
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06003794
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05653888
86* MYC_18940864_ChIP-ChIP_HL60_Human1.04350335
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04127945
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03417879
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02767233
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02726823
91TCF7_22412390_ChIP-Seq_EML_Mouse1.02298446
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01441068
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99836050
94CHD1_26751641_Chip-Seq_LNCaP_Human0.99421309
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99360008
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99221772
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99034046
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98503013
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95428648
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94751503
101* FOXP1_21924763_ChIP-Seq_HESCs_Human0.94188967
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92728467
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92060370
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91065914
105PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90752838
106* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90113704
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88351349
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87260779
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86683217
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86237057
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86179417
112SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85199008
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85102311
114* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85023002
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84193841
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84171917
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.84019952
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.83994136
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83302246
120POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83286417
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82898490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.60218471
2MP0010094_abnormal_chromosome_stability3.58529642
3MP0003111_abnormal_nucleus_morphology3.45339101
4MP0010030_abnormal_orbit_morphology3.16742840
5MP0003077_abnormal_cell_cycle3.10959715
6MP0004957_abnormal_blastocyst_morpholog3.04782497
7MP0003123_paternal_imprinting2.94317362
8MP0009053_abnormal_anal_canal2.55539680
9MP0008057_abnormal_DNA_replication2.50805488
10MP0000537_abnormal_urethra_morphology2.48909813
11MP0003121_genomic_imprinting2.33788130
12MP0002653_abnormal_ependyma_morphology2.21454222
13MP0008877_abnormal_DNA_methylation2.19863065
14MP0001730_embryonic_growth_arrest2.17073809
15MP0008007_abnormal_cellular_replicative2.17010969
16MP0008932_abnormal_embryonic_tissue2.08077248
17MP0003705_abnormal_hypodermis_morpholog2.00404787
18MP0003937_abnormal_limbs/digits/tail_de1.95746782
19* MP0000350_abnormal_cell_proliferation1.95185674
20MP0002085_abnormal_embryonic_tissue1.94766896
21MP0002084_abnormal_developmental_patter1.90139181
22MP0008058_abnormal_DNA_repair1.89216635
23MP0005380_embryogenesis_phenotype1.86446251
24MP0001672_abnormal_embryogenesis/_devel1.86446251
25MP0003890_abnormal_embryonic-extraembry1.83639649
26MP0010352_gastrointestinal_tract_polyps1.72751442
27MP0003567_abnormal_fetal_cardiomyocyte1.69744138
28MP0001697_abnormal_embryo_size1.69542586
29MP0004197_abnormal_fetal_growth/weight/1.67664444
30MP0003315_abnormal_perineum_morphology1.67576152
31MP0003119_abnormal_digestive_system1.67532693
32MP0006292_abnormal_olfactory_placode1.63566291
33MP0008789_abnormal_olfactory_epithelium1.62444906
34MP0001346_abnormal_lacrimal_gland1.62075905
35MP0003984_embryonic_growth_retardation1.61673761
36MP0002088_abnormal_embryonic_growth/wei1.60881488
37MP0003136_yellow_coat_color1.60602417
38MP0001293_anophthalmia1.59872810
39MP0000566_synostosis1.58913900
40MP0002249_abnormal_larynx_morphology1.58319814
41MP0005076_abnormal_cell_differentiation1.51327758
42MP0003385_abnormal_body_wall1.46903056
43MP0002932_abnormal_joint_morphology1.46814726
44MP0002080_prenatal_lethality1.45213164
45MP0000049_abnormal_middle_ear1.44654285
46MP0002086_abnormal_extraembryonic_tissu1.41417013
47MP0001849_ear_inflammation1.39670577
48MP0009379_abnormal_foot_pigmentation1.37369141
49MP0003941_abnormal_skin_development1.36783414
50MP0002938_white_spotting1.34850129
51MP0003935_abnormal_craniofacial_develop1.32885493
52MP0003942_abnormal_urinary_system1.32692765
53MP0005187_abnormal_penis_morphology1.31943114
54MP0009672_abnormal_birth_weight1.31835875
55MP0002111_abnormal_tail_morphology1.31589834
56MP0003755_abnormal_palate_morphology1.27753311
57MP0000428_abnormal_craniofacial_morphol1.27398264
58MP0005248_abnormal_Harderian_gland1.25891719
59MP0002751_abnormal_autonomic_nervous1.24257036
60MP0002092_abnormal_eye_morphology1.19876410
61MP0002233_abnormal_nose_morphology1.19554293
62MP0003861_abnormal_nervous_system1.19296713
63MP0003122_maternal_imprinting1.17806148
64MP0002396_abnormal_hematopoietic_system1.17800814
65MP0003115_abnormal_respiratory_system1.16173856
66MP0010307_abnormal_tumor_latency1.14801283
67MP0001286_abnormal_eye_development1.13296049
68MP0002282_abnormal_trachea_morphology1.13252766
69MP0005499_abnormal_olfactory_system1.12111527
70MP0005394_taste/olfaction_phenotype1.12111527
71* MP0002210_abnormal_sex_determination1.11498198
72MP0009703_decreased_birth_body1.09096584
73MP0002697_abnormal_eye_size1.08166831
74MP0000733_abnormal_muscle_development1.06327363
75MP0000432_abnormal_head_morphology1.04812710
76MP0000490_abnormal_crypts_of1.04032377
77* MP0002116_abnormal_craniofacial_bone1.02909868
78MP0003718_maternal_effect1.01838694
79MP0002102_abnormal_ear_morphology1.01755219
80MP0001188_hyperpigmentation0.99138711
81MP0004808_abnormal_hematopoietic_stem0.98160827
82MP0000313_abnormal_cell_death0.97924307
83MP0002019_abnormal_tumor_incidence0.97478609
84MP0004185_abnormal_adipocyte_glucose0.97461115
85MP0009278_abnormal_bone_marrow0.96441914
86MP0002089_abnormal_postnatal_growth/wei0.95396444
87MP0001145_abnormal_male_reproductive0.95393459
88MP0003878_abnormal_ear_physiology0.93354617
89MP0005377_hearing/vestibular/ear_phenot0.93354617
90MP0003938_abnormal_ear_development0.92712420
91MP0009697_abnormal_copulation0.91996824
92MP0001915_intracranial_hemorrhage0.91869201
93* MP0009250_abnormal_appendicular_skeleto0.91385851
94MP0000579_abnormal_nail_morphology0.90236977
95* MP0000653_abnormal_sex_gland0.89781817
96* MP0001119_abnormal_female_reproductive0.88398316
97MP0000778_abnormal_nervous_system0.87555725
98MP0005367_renal/urinary_system_phenotyp0.87321932
99MP0000516_abnormal_urinary_system0.87321932
100MP0003787_abnormal_imprinting0.87087105
101MP0000631_abnormal_neuroendocrine_gland0.86147271
102MP0002098_abnormal_vibrissa_morphology0.85185312
103* MP0002114_abnormal_axial_skeleton0.84762259
104MP0010234_abnormal_vibrissa_follicle0.84479074
105* MP0002081_perinatal_lethality0.84182886
106MP0002160_abnormal_reproductive_system0.83625146
107MP0001299_abnormal_eye_distance/0.83227813
108MP0001529_abnormal_vocalization0.82001814
109MP0001929_abnormal_gametogenesis0.81790582
110MP0004233_abnormal_muscle_weight0.81789997
111MP0004858_abnormal_nervous_system0.80022042
112MP0002109_abnormal_limb_morphology0.79529242
113MP0002925_abnormal_cardiovascular_devel0.78549444
114MP0002234_abnormal_pharynx_morphology0.77763159
115MP0004264_abnormal_extraembryonic_tissu0.76641863
116MP0000534_abnormal_ureter_morphology0.75318335
117MP0005391_vision/eye_phenotype0.73608626
118MP0002152_abnormal_brain_morphology0.73230191
119MP0003786_premature_aging0.72581572
120MP0004133_heterotaxia0.72565579
121MP0008995_early_reproductive_senescence0.72551169
122MP0001340_abnormal_eyelid_morphology0.72255018

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.96462108
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.96462108
3Renal duplication (HP:0000075)3.51584588
4Patellar aplasia (HP:0006443)3.41751049
5Abnormality of the 4th metacarpal (HP:0010012)3.40171646
6Medulloblastoma (HP:0002885)3.39713234
7Aplasia/Hypoplasia of the patella (HP:0006498)3.33407286
8Increased nuchal translucency (HP:0010880)3.16889523
9Hyperacusis (HP:0010780)3.06737838
10Ependymoma (HP:0002888)3.05242007
11Colon cancer (HP:0003003)3.03962221
12Duplication of thumb phalanx (HP:0009942)2.77745247
13Hepatoblastoma (HP:0002884)2.75515712
14Atresia of the external auditory canal (HP:0000413)2.72784798
15Selective tooth agenesis (HP:0001592)2.72569960
16Birth length less than 3rd percentile (HP:0003561)2.71187018
17Renovascular hypertension (HP:0100817)2.70429374
18Rhabdomyosarcoma (HP:0002859)2.70367029
19Partial duplication of thumb phalanx (HP:0009944)2.69972228
20Ectopic kidney (HP:0000086)2.65324055
21Abnormality of the intervertebral disk (HP:0005108)2.63834678
22Facial hemangioma (HP:0000329)2.61410363
23Neoplasm of striated muscle (HP:0009728)2.58760618
24Abnormality of the labia minora (HP:0012880)2.57826272
25Proximal placement of thumb (HP:0009623)2.53632813
26Abnormal number of incisors (HP:0011064)2.53581847
27Supernumerary spleens (HP:0009799)2.53090954
28Aplasia/Hypoplasia of the sternum (HP:0006714)2.50366568
29Breast hypoplasia (HP:0003187)2.49090365
30Partial duplication of the phalanx of hand (HP:0009999)2.48673282
31Chromsome breakage (HP:0040012)2.46085012
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45248440
33Deviation of the thumb (HP:0009603)2.42098584
34Rib fusion (HP:0000902)2.41830973
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40913471
36Septo-optic dysplasia (HP:0100842)2.40295661
37Asymmetry of the thorax (HP:0001555)2.37307289
38Impulsivity (HP:0100710)2.36033051
39Cortical dysplasia (HP:0002539)2.35634262
40Overriding aorta (HP:0002623)2.35119143
41Trigonocephaly (HP:0000243)2.35009926
42Vaginal fistula (HP:0004320)2.34530760
43Rectal fistula (HP:0100590)2.33789772
44Rectovaginal fistula (HP:0000143)2.33789772
45High anterior hairline (HP:0009890)2.31785162
46Elfin facies (HP:0004428)2.31031406
47Abnormality of cochlea (HP:0000375)2.29049028
48Abnormality of the diencephalon (HP:0010662)2.28512001
49Intestinal fistula (HP:0100819)2.27899279
50Triphalangeal thumb (HP:0001199)2.27531542
51Embryonal renal neoplasm (HP:0011794)2.26060998
52Abnormality of cells of the erythroid lineage (HP:0012130)2.25928349
53Broad distal phalanx of finger (HP:0009836)2.25848877
54Abnormality of the phalanges of the hallux (HP:0010057)2.22779378
55Abnormal lung lobation (HP:0002101)2.20286404
56Meckel diverticulum (HP:0002245)2.20032604
57Long eyelashes (HP:0000527)2.18348396
58Short 5th finger (HP:0009237)2.17898036
59Esophageal atresia (HP:0002032)2.17784584
60Abnormality of the astrocytes (HP:0100707)2.17775254
61Astrocytoma (HP:0009592)2.17775254
62Overlapping toe (HP:0001845)2.14790839
63Choanal stenosis (HP:0000452)2.14102015
64Oligodactyly (HP:0012165)2.12691590
65Volvulus (HP:0002580)2.10474936
66Bilateral microphthalmos (HP:0007633)2.10295004
67Facial cleft (HP:0002006)2.10115304
68Abnormality of the ileum (HP:0001549)2.08555952
69Abnormality of the carotid arteries (HP:0005344)2.08468027
70Absent radius (HP:0003974)2.08328306
71Spina bifida occulta (HP:0003298)2.08191560
72Rectal prolapse (HP:0002035)2.05913984
73Reticulocytopenia (HP:0001896)2.04739147
74Absent epiphyses (HP:0010577)2.03919889
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03919889
76Shawl scrotum (HP:0000049)2.01722397
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.00624089
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99972662
79Pseudobulbar signs (HP:0002200)1.99812750
80Abnormal number of erythroid precursors (HP:0012131)1.99446720
81Hemivertebrae (HP:0002937)1.98979816
82Broad thumb (HP:0011304)1.97741437
83Aplasia involving forearm bones (HP:0009822)1.96541448
84Absent forearm bone (HP:0003953)1.96541448
85Short phalanx of the thumb (HP:0009660)1.96258149
86Oral leukoplakia (HP:0002745)1.96061110
87Neoplasm of the oral cavity (HP:0100649)1.95187427
88Anal stenosis (HP:0002025)1.94188704
89Short thumb (HP:0009778)1.91239245
90Irregular epiphyses (HP:0010582)1.90854172
91Short 1st metacarpal (HP:0010034)1.90560776
92Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90560776
93Abnormality of the fingertips (HP:0001211)1.90471566
94Cutis marmorata (HP:0000965)1.90321462
95Abnormality of chromosome stability (HP:0003220)1.90202974
96Gastrointestinal carcinoma (HP:0002672)1.89698129
97Malignant gastrointestinal tract tumors (HP:0006749)1.89698129
98Hypoplastic labia majora (HP:0000059)1.89618288
99Skin tags (HP:0010609)1.88382094
100Tracheoesophageal fistula (HP:0002575)1.87741381
101Turricephaly (HP:0000262)1.87519218
102Multiple enchondromatosis (HP:0005701)1.86891207
103Anophthalmia (HP:0000528)1.85991096
104Small intestinal stenosis (HP:0012848)1.85914745
105Duodenal stenosis (HP:0100867)1.85914745
106Embryonal neoplasm (HP:0002898)1.85887441
107Morphological abnormality of the inner ear (HP:0011390)1.84345244
108Diastasis recti (HP:0001540)1.84092116
109Preauricular skin tag (HP:0000384)1.83643950
110Macrocytic anemia (HP:0001972)1.83331973
111Abdominal situs inversus (HP:0003363)1.82934186
112Abnormality of abdominal situs (HP:0011620)1.82934186
113Degeneration of anterior horn cells (HP:0002398)1.82760758
114Abnormality of the anterior horn cell (HP:0006802)1.82760758
115Flat cornea (HP:0007720)1.81265452
116Supernumerary ribs (HP:0005815)1.80318291
117Absent thumb (HP:0009777)1.79903991
118Midline defect of the nose (HP:0004122)1.79497304
119Glioma (HP:0009733)1.78832077
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78611171
121Neoplasm of the adrenal cortex (HP:0100641)1.78532426
122Neoplasm of the pancreas (HP:0002894)1.78497161
123Short middle phalanx of the 5th finger (HP:0004220)1.77701874
124Broad phalanges of the hand (HP:0009768)1.75779383
125Supernumerary bones of the axial skeleton (HP:0009144)1.75711594
126Abnormality of the duodenum (HP:0002246)1.75067533
127Pelvic girdle muscle weakness (HP:0003749)1.74889688
128Missing ribs (HP:0000921)1.73706595
129Abnormality of the preputium (HP:0100587)1.73695610
130Coronal craniosynostosis (HP:0004440)1.72609519
131Basal cell carcinoma (HP:0002671)1.72383235
132Abnormality of the labia majora (HP:0012881)1.71775700
133Maternal diabetes (HP:0009800)1.71501500
134Insomnia (HP:0100785)1.70983127
135Nephroblastoma (Wilms tumor) (HP:0002667)1.70866732
136Microvesicular hepatic steatosis (HP:0001414)1.70612952
137Abnormality of the lacrimal duct (HP:0011481)1.69340874
138Obsessive-compulsive behavior (HP:0000722)1.69003636
139Horseshoe kidney (HP:0000085)1.68965083
140Deviation of the hallux (HP:0010051)1.68821238
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.68565236
142Partial agenesis of the corpus callosum (HP:0001338)1.67779479
143Skull defect (HP:0001362)1.67124696
144Generalized hypotonia (HP:0001290)1.66890440
145Absent septum pellucidum (HP:0001331)1.65549425
146Myelomeningocele (HP:0002475)1.65442871
147Abnormality of the septum pellucidum (HP:0007375)1.65409753
148Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64923092
149Broad finger (HP:0001500)1.64449925
150Abnormality of the calcaneus (HP:0008364)1.63260197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.71007271
2EEF2K3.97295284
3MAP3K103.31628870
4CDK123.15093837
5NEK23.04350060
6LATS12.86746384
7BUB12.76450733
8SMG12.73153500
9VRK22.62776396
10TTK2.37906502
11WEE12.31918192
12PLK42.16893485
13LATS22.14091148
14PKN21.99158664
15ZAK1.93912383
16TAF11.92523641
17MKNK11.92522210
18RPS6KB21.90665347
19TRIB31.87138290
20CDK71.83601155
21SRPK11.80905450
22CDK41.80043510
23PBK1.76309208
24RPS6KA41.72088088
25DYRK31.67325855
26PLK11.65804811
27PASK1.63033160
28ACVR1B1.53824451
29CHEK21.47077742
30BRD41.44364136
31ATR1.44342798
32AURKB1.43052240
33NME21.38928111
34STK38L1.36208729
35MKNK21.35089781
36CHEK11.33866253
37MAP3K81.31942782
38CDK61.31766858
39STK101.30214364
40NEK11.30156809
41TGFBR11.24382373
42MELK1.23930861
43STK31.21813536
44CAMK1D1.16957906
45CDK91.16649521
46CAMK1G1.15974685
47PNCK1.13056080
48MAPKAPK31.10039158
49CDK81.08210717
50PAK41.06442214
51PLK31.06242787
52EPHB21.05587557
53MTOR1.05489721
54ICK1.05477638
55AURKA1.02141116
56TESK21.00141258
57TSSK60.97676419
58CDK20.97457304
59FGFR40.96544853
60STK40.96076371
61PDGFRA0.94550088
62TYRO30.91720998
63ATM0.91472315
64NME10.83715629
65PTK60.79715745
66DYRK20.78785469
67FGFR10.77958700
68LRRK20.76482994
69CDK190.76376131
70VRK10.75383030
71CDK10.74269939
72AKT20.73610918
73KSR10.72664200
74TRIM280.70940089
75BRSK10.70012289
76ALK0.66201893
77BRAF0.65937912
78BRSK20.65625253
79MAP3K60.64533752
80EIF2AK10.64441047
81ERBB20.62561273
82SCYL20.61504783
83CDK11A0.58895651
84BMX0.58648317
85TLK10.57011718
86CSNK1E0.55721569
87MAPK110.55558780
88CDK150.54815248
89SIK10.54616176
90PRKD30.53574633
91KDR0.51930514
92MAP2K20.51795521
93CDK180.51348863
94MAP3K90.50609806
95MOS0.50586286
96ERBB30.49832474
97CSNK1G10.48107619
98CDK30.47522000
99RPS6KA10.46457249
100FGFR20.46273929
101STK160.44238321
102AKT10.42500186
103FLT30.42243892
104PAK10.41732011
105CDK140.41238867
106ERBB40.41176052
107PAK20.40782322
108CSNK1D0.40690584
109RPS6KL10.40000735
110RPS6KC10.40000735
111MAPK140.39709700
112CSNK1A1L0.39109254
113UHMK10.38248507
114CSNK2A20.37552011
115EIF2AK20.36771602
116PIM10.36248154
117CSNK2A10.35993734
118CSNK1G30.35921875
119PRKDC0.34936371
120GRK60.34080144
121ILK0.33376855
122GSK3B0.31514060
123EPHA20.28617778
124MAPK10.27235973
125TTN0.26987488
126HIPK20.25511761
127DYRK1B0.25281489
128TAOK10.25184622

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61635739
2Mismatch repair_Homo sapiens_hsa034304.02499722
3Spliceosome_Homo sapiens_hsa030403.39284345
4Cell cycle_Homo sapiens_hsa041103.34910738
5Base excision repair_Homo sapiens_hsa034103.01916178
6RNA transport_Homo sapiens_hsa030133.01372996
7Homologous recombination_Homo sapiens_hsa034402.66744420
8One carbon pool by folate_Homo sapiens_hsa006702.60992573
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59243129
10mRNA surveillance pathway_Homo sapiens_hsa030152.42520861
11Nucleotide excision repair_Homo sapiens_hsa034202.33528699
12Basal cell carcinoma_Homo sapiens_hsa052172.15703106
13RNA polymerase_Homo sapiens_hsa030202.06414036
14Fanconi anemia pathway_Homo sapiens_hsa034602.04716552
15RNA degradation_Homo sapiens_hsa030181.91851966
16Basal transcription factors_Homo sapiens_hsa030221.84779804
17Pyrimidine metabolism_Homo sapiens_hsa002401.71710937
18Ribosome_Homo sapiens_hsa030101.67830708
19Non-homologous end-joining_Homo sapiens_hsa034501.64824152
20Notch signaling pathway_Homo sapiens_hsa043301.62921092
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62686260
22MicroRNAs in cancer_Homo sapiens_hsa052061.56867931
23Hippo signaling pathway_Homo sapiens_hsa043901.53432238
24Hedgehog signaling pathway_Homo sapiens_hsa043401.52448167
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49726229
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47894314
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47757482
28p53 signaling pathway_Homo sapiens_hsa041151.46149987
29Lysine degradation_Homo sapiens_hsa003101.39575581
30Oocyte meiosis_Homo sapiens_hsa041141.33770419
31Colorectal cancer_Homo sapiens_hsa052101.24901058
32Chronic myeloid leukemia_Homo sapiens_hsa052201.22456179
33Systemic lupus erythematosus_Homo sapiens_hsa053221.20043638
34Selenocompound metabolism_Homo sapiens_hsa004501.19594438
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.17677207
36Vitamin B6 metabolism_Homo sapiens_hsa007501.15912194
37Thyroid cancer_Homo sapiens_hsa052161.15421337
38HTLV-I infection_Homo sapiens_hsa051661.14987702
39TGF-beta signaling pathway_Homo sapiens_hsa043501.06082023
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05525048
41Steroid biosynthesis_Homo sapiens_hsa001001.04965882
42Viral carcinogenesis_Homo sapiens_hsa052031.02439694
43Endometrial cancer_Homo sapiens_hsa052130.97628510
44Small cell lung cancer_Homo sapiens_hsa052220.97380458
45Adherens junction_Homo sapiens_hsa045200.95916983
46Biosynthesis of amino acids_Homo sapiens_hsa012300.95819666
47Pyruvate metabolism_Homo sapiens_hsa006200.95287038
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95039292
49Herpes simplex infection_Homo sapiens_hsa051680.92140738
50Epstein-Barr virus infection_Homo sapiens_hsa051690.90390159
51Wnt signaling pathway_Homo sapiens_hsa043100.90251783
52Proteasome_Homo sapiens_hsa030500.87289908
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86675341
54Bladder cancer_Homo sapiens_hsa052190.83991988
55Non-small cell lung cancer_Homo sapiens_hsa052230.83536200
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.77270109
57Pathways in cancer_Homo sapiens_hsa052000.73698982
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.68219948
59Prostate cancer_Homo sapiens_hsa052150.67168741
60mTOR signaling pathway_Homo sapiens_hsa041500.66296517
61Pancreatic cancer_Homo sapiens_hsa052120.65878450
62Purine metabolism_Homo sapiens_hsa002300.65783294
63Proteoglycans in cancer_Homo sapiens_hsa052050.65345900
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65026315
65Huntingtons disease_Homo sapiens_hsa050160.63432927
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61914383
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.59270819
68Acute myeloid leukemia_Homo sapiens_hsa052210.56174588
69N-Glycan biosynthesis_Homo sapiens_hsa005100.55470173
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55430750
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54796773
72Alcoholism_Homo sapiens_hsa050340.54104984
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53512804
74Viral myocarditis_Homo sapiens_hsa054160.52244741
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50006179
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49501762
77Vitamin digestion and absorption_Homo sapiens_hsa049770.49419134
78Hepatitis B_Homo sapiens_hsa051610.48773531
79Fructose and mannose metabolism_Homo sapiens_hsa000510.47599843
80Fatty acid metabolism_Homo sapiens_hsa012120.47326560
81Tight junction_Homo sapiens_hsa045300.46844458
82Arginine and proline metabolism_Homo sapiens_hsa003300.45921965
83Sulfur relay system_Homo sapiens_hsa041220.43645320
84Galactose metabolism_Homo sapiens_hsa000520.41931542
85Melanoma_Homo sapiens_hsa052180.40627652
86FoxO signaling pathway_Homo sapiens_hsa040680.40543164
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39854897
88Folate biosynthesis_Homo sapiens_hsa007900.39175051
89Pentose phosphate pathway_Homo sapiens_hsa000300.37445357
90Fatty acid elongation_Homo sapiens_hsa000620.37002750
91Parkinsons disease_Homo sapiens_hsa050120.36665387
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35511238
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35081084
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.34889934
95Arginine biosynthesis_Homo sapiens_hsa002200.33723678
96Melanogenesis_Homo sapiens_hsa049160.33332313
97Metabolic pathways_Homo sapiens_hsa011000.33158372
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32954656
99Glioma_Homo sapiens_hsa052140.31526962
100AMPK signaling pathway_Homo sapiens_hsa041520.31422436
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30416926
102Apoptosis_Homo sapiens_hsa042100.30228990
103ErbB signaling pathway_Homo sapiens_hsa040120.29995891
104Renal cell carcinoma_Homo sapiens_hsa052110.29316540
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26409481
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24548467
107Glutathione metabolism_Homo sapiens_hsa004800.24284518
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24209719
109Prolactin signaling pathway_Homo sapiens_hsa049170.23439362
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23020502
111Antigen processing and presentation_Homo sapiens_hsa046120.22993295
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22709351
113Shigellosis_Homo sapiens_hsa051310.22509352
114Insulin signaling pathway_Homo sapiens_hsa049100.22142814
115Carbon metabolism_Homo sapiens_hsa012000.21204436
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21105159
117VEGF signaling pathway_Homo sapiens_hsa043700.20598355
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19800600
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18938320
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17174774
121Axon guidance_Homo sapiens_hsa043600.16156791
122HIF-1 signaling pathway_Homo sapiens_hsa040660.15595649
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14573230
124Focal adhesion_Homo sapiens_hsa045100.14395084

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