CBX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.23331957
2CENP-A containing nucleosome assembly (GO:0034080)5.10986269
3chromatin remodeling at centromere (GO:0031055)4.91199681
4establishment of integrated proviral latency (GO:0075713)4.90762526
5telomere maintenance via semi-conservative replication (GO:0032201)4.84725662
6kinetochore assembly (GO:0051382)4.61785801
7DNA strand elongation involved in DNA replication (GO:0006271)4.57012934
8telomere maintenance via recombination (GO:0000722)4.54095212
9DNA strand elongation (GO:0022616)4.45116514
10mitotic recombination (GO:0006312)4.41374128
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.28941140
12formation of translation preinitiation complex (GO:0001731)4.28778930
13ribosomal large subunit biogenesis (GO:0042273)4.26392435
14DNA ligation (GO:0006266)4.23301114
15mitotic metaphase plate congression (GO:0007080)4.19614945
16DNA replication-independent nucleosome organization (GO:0034724)4.19042429
17DNA replication-independent nucleosome assembly (GO:0006336)4.19042429
18DNA replication initiation (GO:0006270)4.17692174
19DNA replication checkpoint (GO:0000076)4.16866127
20IMP biosynthetic process (GO:0006188)4.05133961
21mitotic sister chromatid cohesion (GO:0007064)4.00622356
22attachment of spindle microtubules to kinetochore (GO:0008608)3.98178857
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.91014572
24ribosome assembly (GO:0042255)3.89921551
25viral mRNA export from host cell nucleus (GO:0046784)3.89232443
26histone exchange (GO:0043486)3.89122086
27purine nucleobase biosynthetic process (GO:0009113)3.87434990
28telomere maintenance via telomere lengthening (GO:0010833)3.84519844
29meiotic chromosome segregation (GO:0045132)3.80625767
30ribosomal small subunit biogenesis (GO:0042274)3.79827317
31viral transcription (GO:0019083)3.77823438
32translational termination (GO:0006415)3.77630906
33maturation of SSU-rRNA (GO:0030490)3.77284617
34ribosomal small subunit assembly (GO:0000028)3.76563417
35metaphase plate congression (GO:0051310)3.76173104
36establishment of chromosome localization (GO:0051303)3.75717739
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.74101642
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.72402144
39regulation of centriole replication (GO:0046599)3.69380186
40nucleobase biosynthetic process (GO:0046112)3.67409342
41establishment of viral latency (GO:0019043)3.65975574
42regulation of mitotic spindle checkpoint (GO:1903504)3.61936522
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61936522
44deoxyribonucleotide biosynthetic process (GO:0009263)3.60357770
45RNA-dependent DNA replication (GO:0006278)3.54535019
46translational initiation (GO:0006413)3.52127886
47pore complex assembly (GO:0046931)3.51732799
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50715370
49cotranslational protein targeting to membrane (GO:0006613)3.47824424
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46036348
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44942453
52mitotic nuclear envelope disassembly (GO:0007077)3.44568199
53transcription-coupled nucleotide-excision repair (GO:0006283)3.42188776
54protein targeting to ER (GO:0045047)3.41663229
55ribonucleoprotein complex biogenesis (GO:0022613)3.38108853
56protein localization to kinetochore (GO:0034501)3.36718194
57IMP metabolic process (GO:0046040)3.35927102
58DNA deamination (GO:0045006)3.35897471
59proteasome assembly (GO:0043248)3.35499737
60cullin deneddylation (GO:0010388)3.35031734
61DNA topological change (GO:0006265)3.34022162
62nuclear pore organization (GO:0006999)3.33006500
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32415886
64microtubule depolymerization (GO:0007019)3.30442973
65mitotic sister chromatid segregation (GO:0000070)3.29829647
66translational elongation (GO:0006414)3.29220570
67regulation of chromosome segregation (GO:0051983)3.29072626
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29031572
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.26925875
70DNA double-strand break processing (GO:0000729)3.25814437
71telomere maintenance (GO:0000723)3.25152010
72regulation of translational fidelity (GO:0006450)3.25145431
73DNA unwinding involved in DNA replication (GO:0006268)3.24676097
74telomere organization (GO:0032200)3.21829172
75membrane disassembly (GO:0030397)3.20500179
76nuclear envelope disassembly (GO:0051081)3.20500179
77ATP-dependent chromatin remodeling (GO:0043044)3.20242275
78regulation of centrosome cycle (GO:0046605)3.19870955
79DNA-dependent DNA replication (GO:0006261)3.18465613
80protein localization to endoplasmic reticulum (GO:0070972)3.17669369
81regulation of mitotic spindle organization (GO:0060236)3.17161365
82mitotic chromosome condensation (GO:0007076)3.14268137
83negative regulation of chromosome segregation (GO:0051985)3.14259722
84negative regulation of RNA splicing (GO:0033119)3.14250647
85protein localization to chromosome, centromeric region (GO:0071459)3.14082155
86chromatin assembly or disassembly (GO:0006333)3.13985688
87termination of RNA polymerase II transcription (GO:0006369)3.13789996
88sister chromatid segregation (GO:0000819)3.13179878
89deoxyribose phosphate biosynthetic process (GO:0046385)3.12170034
902-deoxyribonucleotide biosynthetic process (GO:0009265)3.12170034
91mitotic spindle checkpoint (GO:0071174)3.12035879
92chromosome condensation (GO:0030261)3.09973636
93regulation of spindle organization (GO:0090224)3.09895254
94DNA replication (GO:0006260)3.09388142
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08789871
96protein deneddylation (GO:0000338)3.08706825
97histone H2A acetylation (GO:0043968)3.08587220
98maturation of 5.8S rRNA (GO:0000460)3.08210952
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08116439
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07555657
101DNA duplex unwinding (GO:0032508)3.07166650
102ribosome biogenesis (GO:0042254)3.07089996
103regulation of sister chromatid cohesion (GO:0007063)3.06760454
104positive regulation of chromosome segregation (GO:0051984)3.06733987
105spindle checkpoint (GO:0031577)3.05354646
106pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04887109
107replication fork processing (GO:0031297)3.04086014
108cellular protein complex disassembly (GO:0043624)3.04041320
109V(D)J recombination (GO:0033151)3.03968939
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03409667
111nucleobase-containing small molecule interconversion (GO:0015949)3.03071997
112folic acid-containing compound biosynthetic process (GO:0009396)3.02964462
113viral life cycle (GO:0019058)3.02335669
114negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02010411
115nuclear pore complex assembly (GO:0051292)3.00878211
116mitotic spindle assembly checkpoint (GO:0007094)3.00155221
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00042140
118DNA geometric change (GO:0032392)3.00001836
119negative regulation of mRNA processing (GO:0050686)2.99908893
120protein complex localization (GO:0031503)2.99271077
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97984502
1227-methylguanosine mRNA capping (GO:0006370)2.97747472
123RNA capping (GO:0036260)2.97594353
1247-methylguanosine RNA capping (GO:0009452)2.97594353
125non-recombinational repair (GO:0000726)2.97165890
126double-strand break repair via nonhomologous end joining (GO:0006303)2.97165890
127negative regulation of phagocytosis (GO:0050765)2.96386839
128chromosome segregation (GO:0007059)2.96088059
129protein K6-linked ubiquitination (GO:0085020)2.95780191
130transcription from RNA polymerase I promoter (GO:0006360)2.92379123
131termination of RNA polymerase III transcription (GO:0006386)2.92118820
132transcription elongation from RNA polymerase III promoter (GO:0006385)2.92118820
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91074013
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90775936
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90775936
136DNA synthesis involved in DNA repair (GO:0000731)2.89869457
137cell cycle G1/S phase transition (GO:0044843)2.89006382
138G1/S transition of mitotic cell cycle (GO:0000082)2.89006382
139mismatch repair (GO:0006298)2.88977765
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87059674
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.86087138
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86087138
143transcription initiation from RNA polymerase I promoter (GO:0006361)2.85911111
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.84880329
145regulation of transcription from RNA polymerase I promoter (GO:0006356)2.84624723
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84615151
147negative regulation of sister chromatid segregation (GO:0033046)2.84615151
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.84615151
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84615151
150spliceosomal complex assembly (GO:0000245)2.84488747
151spliceosomal snRNP assembly (GO:0000387)2.84465103
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84458109
153regulation of mitotic sister chromatid segregation (GO:0033047)2.82169183
154regulation of sister chromatid segregation (GO:0033045)2.82169183
155regulation of mitotic sister chromatid separation (GO:0010965)2.82169183
156spindle assembly checkpoint (GO:0071173)2.81822141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.48640955
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20638898
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.79893811
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64861446
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.48507205
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36891279
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26149638
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86945758
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74412664
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.73315839
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73020638
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65354897
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62184493
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43860271
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42854396
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40306528
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35628240
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32714960
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31192267
20ELK1_19687146_ChIP-ChIP_HELA_Human2.30746208
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29425721
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.29253797
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25561553
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.20487893
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.19496603
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17123758
27AR_21909140_ChIP-Seq_LNCAP_Human2.16851255
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.16109528
29VDR_23849224_ChIP-Seq_CD4+_Human2.16071658
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14882815
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07826802
32FOXP3_21729870_ChIP-Seq_TREG_Human2.07013296
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05576823
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03949039
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03674604
36E2F7_22180533_ChIP-Seq_HELA_Human10.1766790
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99850364
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98519250
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.89008937
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87876299
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87531208
42DCP1A_22483619_ChIP-Seq_HELA_Human1.85985776
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79111001
44XRN2_22483619_ChIP-Seq_HELA_Human1.78398698
45* TTF2_22483619_ChIP-Seq_HELA_Human1.66141772
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65488581
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.64303460
48GABP_19822575_ChIP-Seq_HepG2_Human1.55149730
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53750575
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51600757
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47970924
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47964819
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46489348
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44784524
55CIITA_25753668_ChIP-Seq_RAJI_Human1.39232697
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39178822
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38077262
58MYC_18940864_ChIP-ChIP_HL60_Human1.37066966
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28141862
60EWS_26573619_Chip-Seq_HEK293_Human1.27005440
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26526148
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25410559
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20975624
64IRF1_19129219_ChIP-ChIP_H3396_Human1.19739870
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18467788
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16747968
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16311277
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15331580
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.14952691
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14736185
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.14438295
72* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11026779
73ZNF263_19887448_ChIP-Seq_K562_Human1.10321780
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09704548
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08663489
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05728324
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03993232
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03581676
79* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03334178
80MYC_22102868_ChIP-Seq_BL_Human1.02220590
81* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01098896
82KDM5A_27292631_Chip-Seq_BREAST_Human0.99759044
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96168223
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95839975
85FUS_26573619_Chip-Seq_HEK293_Human0.95779615
86CHD1_26751641_Chip-Seq_LNCaP_Human0.94884312
87* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92873223
88* SOX2_16153702_ChIP-ChIP_HESCs_Human0.91279248
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.90380231
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.90191968
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.90040142
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89551032
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88223778
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87937557
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87844333
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87784379
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84847647
98GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79738446
99TFEB_21752829_ChIP-Seq_HELA_Human0.79655900
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.79197148
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78753675
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73696262
103* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71813254
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71807306
105ELF5_23300383_ChIP-Seq_T47D_Human0.71064439
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.70177403
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.68813512
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66359184
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64582322
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64032056
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.61380337
112* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.59318287
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.58660390
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.58457722
115SOX9_26525672_Chip-Seq_HEART_Mouse0.57890253
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.57671300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.18078920
2MP0008057_abnormal_DNA_replication3.45680868
3MP0008007_abnormal_cellular_replicative3.38955736
4MP0003693_abnormal_embryo_hatching3.37942727
5MP0008058_abnormal_DNA_repair3.26309707
6MP0003111_abnormal_nucleus_morphology3.21800295
7MP0003077_abnormal_cell_cycle3.05670669
8MP0006292_abnormal_olfactory_placode2.98598704
9MP0000566_synostosis2.86755070
10MP0004957_abnormal_blastocyst_morpholog2.78608776
11MP0008877_abnormal_DNA_methylation2.76016299
12MP0003121_genomic_imprinting2.34779021
13MP0003786_premature_aging2.24190350
14MP0003123_paternal_imprinting2.23290583
15MP0002396_abnormal_hematopoietic_system2.18738681
16MP0008932_abnormal_embryonic_tissue2.12491310
17MP0001188_hyperpigmentation2.12169183
18MP0003315_abnormal_perineum_morphology2.11834382
19MP0002877_abnormal_melanocyte_morpholog2.06803685
20MP0002009_preneoplasia2.02161745
21MP0003787_abnormal_imprinting2.01912664
22MP0000537_abnormal_urethra_morphology1.97716955
23MP0000015_abnormal_ear_pigmentation1.96348497
24MP0008789_abnormal_olfactory_epithelium1.93452500
25MP0009697_abnormal_copulation1.92552046
26MP0005408_hypopigmentation1.84339521
27MP0002084_abnormal_developmental_patter1.62968362
28MP0005394_taste/olfaction_phenotype1.61111174
29MP0005499_abnormal_olfactory_system1.61111174
30MP0010234_abnormal_vibrissa_follicle1.60950332
31MP0010030_abnormal_orbit_morphology1.59874305
32MP0004808_abnormal_hematopoietic_stem1.59602555
33MP0000516_abnormal_urinary_system1.57288579
34MP0005367_renal/urinary_system_phenotyp1.57288579
35MP0005075_abnormal_melanosome_morpholog1.54133914
36MP0002697_abnormal_eye_size1.52704978
37MP0010352_gastrointestinal_tract_polyps1.50726048
38MP0000049_abnormal_middle_ear1.49304804
39MP0000350_abnormal_cell_proliferation1.48828308
40MP0009053_abnormal_anal_canal1.46854562
41MP0002160_abnormal_reproductive_system1.42702162
42MP0003941_abnormal_skin_development1.42190481
43MP0003122_maternal_imprinting1.37948400
44MP0003718_maternal_effect1.36744770
45MP0002095_abnormal_skin_pigmentation1.35184635
46MP0004782_abnormal_surfactant_physiolog1.31731388
47MP0002938_white_spotting1.31694077
48MP0001119_abnormal_female_reproductive1.31668331
49MP0003943_abnormal_hepatobiliary_system1.27664300
50MP0002751_abnormal_autonomic_nervous1.26627421
51MP0004185_abnormal_adipocyte_glucose1.22197369
52MP0002210_abnormal_sex_determination1.19954304
53MP0005076_abnormal_cell_differentiation1.19488945
54MP0001730_embryonic_growth_arrest1.17589866
55MP0003567_abnormal_fetal_cardiomyocyte1.15305482
56MP0001672_abnormal_embryogenesis/_devel1.14622377
57MP0005380_embryogenesis_phenotype1.14622377
58MP0001177_atelectasis1.12319050
59MP0003937_abnormal_limbs/digits/tail_de1.11396888
60MP0001697_abnormal_embryo_size1.09502390
61MP0005389_reproductive_system_phenotype1.09378480
62MP0005171_absent_coat_pigmentation1.08169383
63MP0005409_darkened_coat_color1.07504647
64MP0003221_abnormal_cardiomyocyte_apopto1.07345938
65MP0000313_abnormal_cell_death1.06304325
66MP0002092_abnormal_eye_morphology1.05212789
67MP0000490_abnormal_crypts_of1.04553510
68MP0003763_abnormal_thymus_physiology1.00589322
69MP0003984_embryonic_growth_retardation1.00076649
70MP0001186_pigmentation_phenotype0.99473232
71MP0001293_anophthalmia0.98665333
72MP0006035_abnormal_mitochondrial_morpho0.98634172
73MP0006054_spinal_hemorrhage0.98084111
74MP0001919_abnormal_reproductive_system0.97673395
75MP0002132_abnormal_respiratory_system0.97298349
76MP0002088_abnormal_embryonic_growth/wei0.97201641
77MP0001881_abnormal_mammary_gland0.96993816
78MP0001286_abnormal_eye_development0.96105401
79MP0005501_abnormal_skin_physiology0.95702153
80MP0000358_abnormal_cell_content/0.95436348
81MP0003942_abnormal_urinary_system0.95009234
82MP0003861_abnormal_nervous_system0.91961586
83MP0003890_abnormal_embryonic-extraembry0.91193523
84MP0009703_decreased_birth_body0.91093727
85MP0001346_abnormal_lacrimal_gland0.90745840
86MP0004197_abnormal_fetal_growth/weight/0.90383112
87MP0002796_impaired_skin_barrier0.88767470
88MP0003186_abnormal_redox_activity0.87444435
89MP0002177_abnormal_outer_ear0.86853534
90MP0002085_abnormal_embryonic_tissue0.86829704
91MP0001145_abnormal_male_reproductive0.86551157
92MP0000653_abnormal_sex_gland0.86152137
93MP0000372_irregular_coat_pigmentation0.85540368
94MP0005174_abnormal_tail_pigmentation0.85367058
95MP0003115_abnormal_respiratory_system0.85331711
96MP0000627_abnormal_mammary_gland0.84468564
97MP0002233_abnormal_nose_morphology0.84299803
98MP0003385_abnormal_body_wall0.84149733
99MP0003935_abnormal_craniofacial_develop0.83353965
100MP0003755_abnormal_palate_morphology0.83019080
101MP0000428_abnormal_craniofacial_morphol0.82385685
102MP0000579_abnormal_nail_morphology0.81930253
103MP0009250_abnormal_appendicular_skeleto0.81436124
104MP0002249_abnormal_larynx_morphology0.80598258
105MP0000631_abnormal_neuroendocrine_gland0.79712286
106MP0002080_prenatal_lethality0.79685132
107MP0008995_early_reproductive_senescence0.79622710
108MP0002234_abnormal_pharynx_morphology0.79466263
109MP0001929_abnormal_gametogenesis0.78119746
110MP0001340_abnormal_eyelid_morphology0.78059622
111MP0009379_abnormal_foot_pigmentation0.77702487
112MP0000762_abnormal_tongue_morphology0.77615773
113MP0004147_increased_porphyrin_level0.77449757
114MP0009672_abnormal_birth_weight0.76707306
115MP0002019_abnormal_tumor_incidence0.76627013
116MP0000647_abnormal_sebaceous_gland0.76115221
117MP0005646_abnormal_pituitary_gland0.74901870
118MP0002111_abnormal_tail_morphology0.74558563
119MP0005187_abnormal_penis_morphology0.74504312
120MP0000678_abnormal_parathyroid_gland0.73655290
121MP0003705_abnormal_hypodermis_morpholog0.72553661
122MP0006072_abnormal_retinal_apoptosis0.71366727
123MP0004264_abnormal_extraembryonic_tissu0.70988416
124MP0002075_abnormal_coat/hair_pigmentati0.70249945
125MP0001529_abnormal_vocalization0.68669938
126MP0000681_abnormal_thyroid_gland0.68304909
127MP0010307_abnormal_tumor_latency0.68080819
128MP0002081_perinatal_lethality0.67325855
129MP0003119_abnormal_digestive_system0.66843409
130MP0002086_abnormal_extraembryonic_tissu0.66495425
131MP0002098_abnormal_vibrissa_morphology0.66243932
132MP0000432_abnormal_head_morphology0.65627250
133MP0002163_abnormal_gland_morphology0.63988894

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46972017
2Chromsome breakage (HP:0040012)4.46837771
3Birth length less than 3rd percentile (HP:0003561)4.40409417
4Abnormal lung lobation (HP:0002101)3.64880059
5Degeneration of anterior horn cells (HP:0002398)3.48481613
6Abnormality of the anterior horn cell (HP:0006802)3.48481613
7Patellar aplasia (HP:0006443)3.38454585
8Increased nuchal translucency (HP:0010880)3.35865706
911 pairs of ribs (HP:0000878)3.34029470
10Aplasia/Hypoplasia of the patella (HP:0006498)3.29480949
11Nephroblastoma (Wilms tumor) (HP:0002667)3.25391335
12Cortical dysplasia (HP:0002539)3.14424523
13Embryonal renal neoplasm (HP:0011794)3.14420842
14Meckel diverticulum (HP:0002245)3.11883539
15Breast hypoplasia (HP:0003187)3.11707831
16Ectopic kidney (HP:0000086)3.06129212
17Macrocytic anemia (HP:0001972)3.03194214
18Abnormality of cells of the erythroid lineage (HP:0012130)3.03090172
19Abnormality of the ileum (HP:0001549)2.94606929
20Spinal cord lesions (HP:0100561)2.86717063
21Syringomyelia (HP:0003396)2.86717063
22Abnormality of the preputium (HP:0100587)2.85667958
23Abnormality of chromosome stability (HP:0003220)2.80315171
24Impulsivity (HP:0100710)2.77696801
25Volvulus (HP:0002580)2.71104902
26Aplastic anemia (HP:0001915)2.70505338
27Type I transferrin isoform profile (HP:0003642)2.68090260
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.66933385
29Asymmetry of the thorax (HP:0001555)2.62160514
30Multiple enchondromatosis (HP:0005701)2.60542712
31Pallor (HP:0000980)2.55385594
32Small intestinal stenosis (HP:0012848)2.50768355
33Duodenal stenosis (HP:0100867)2.50768355
34True hermaphroditism (HP:0010459)2.47734091
35Optic nerve coloboma (HP:0000588)2.43077172
36Carpal bone hypoplasia (HP:0001498)2.38459727
37Myelodysplasia (HP:0002863)2.36956971
38Increased hepatocellular lipid droplets (HP:0006565)2.35117397
39Type 2 muscle fiber atrophy (HP:0003554)2.31582454
40Clubbing of toes (HP:0100760)2.31509322
41Deep philtrum (HP:0002002)2.30741908
42Abnormality of the renal collecting system (HP:0004742)2.28299929
43Rectovaginal fistula (HP:0000143)2.25205874
44Rectal fistula (HP:0100590)2.25205874
45Proximal placement of thumb (HP:0009623)2.21671048
46Bone marrow hypocellularity (HP:0005528)2.21019753
47Pancreatic fibrosis (HP:0100732)2.18974016
48B lymphocytopenia (HP:0010976)2.18772044
49Cutaneous melanoma (HP:0012056)2.17249833
50Neoplasm of the colon (HP:0100273)2.17025075
51Preaxial hand polydactyly (HP:0001177)2.16017529
52Intestinal fistula (HP:0100819)2.15897393
53Absent thumb (HP:0009777)2.15266478
54Supernumerary spleens (HP:0009799)2.12767961
55Deviation of the thumb (HP:0009603)2.12402408
56Rhabdomyosarcoma (HP:0002859)2.12126592
57Increased serum pyruvate (HP:0003542)2.11174027
58Duplicated collecting system (HP:0000081)2.10646142
59Abnormality of glycolysis (HP:0004366)2.09825861
60Diastasis recti (HP:0001540)2.09312032
61Insidious onset (HP:0003587)2.08787003
62Termporal pattern (HP:0011008)2.08787003
63Cafe-au-lait spot (HP:0000957)2.07738107
64Colon cancer (HP:0003003)2.07158247
65Abnormality of the duodenum (HP:0002246)2.06941980
66Sloping forehead (HP:0000340)2.05179840
67Abnormal hair whorl (HP:0010721)2.04066110
68Reticulocytopenia (HP:0001896)2.02866780
69Short 4th metacarpal (HP:0010044)2.01619955
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01619955
71Overlapping toe (HP:0001845)1.98164610
72Triphalangeal thumb (HP:0001199)1.97111898
73Arteriovenous malformation (HP:0100026)1.95043885
74Muscle fiber atrophy (HP:0100295)1.91592874
75Long clavicles (HP:0000890)1.91497835
76Abnormality of the metopic suture (HP:0005556)1.91227824
77Oral leukoplakia (HP:0002745)1.91097952
78Abnormality of the intervertebral disk (HP:0005108)1.89491032
79Lipid accumulation in hepatocytes (HP:0006561)1.89136410
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.88709324
81Abnormality of the columella (HP:0009929)1.88027676
82Choanal atresia (HP:0000453)1.87796011
83Abnormal number of incisors (HP:0011064)1.87543794
84Overriding aorta (HP:0002623)1.87247635
85Abnormal number of erythroid precursors (HP:0012131)1.86242911
86Microglossia (HP:0000171)1.85023846
87Breast carcinoma (HP:0003002)1.84777795
88Insomnia (HP:0100785)1.83351605
89Short middle phalanx of the 5th finger (HP:0004220)1.82278996
90Abnormality of methionine metabolism (HP:0010901)1.82136406
91Embryonal neoplasm (HP:0002898)1.81003138
92Absent radius (HP:0003974)1.80544226
93Premature graying of hair (HP:0002216)1.80219490
94Pancreatic cysts (HP:0001737)1.79311320
95Progressive external ophthalmoplegia (HP:0000590)1.79085727
96Abnormality of the labia minora (HP:0012880)1.78986712
97Horseshoe kidney (HP:0000085)1.78829178
98Abnormality of incisor morphology (HP:0011063)1.77647645
99Postaxial foot polydactyly (HP:0001830)1.75234255
100Atresia of the external auditory canal (HP:0000413)1.73565243
101Neoplasm of the adrenal cortex (HP:0100641)1.72691852
102Stenosis of the external auditory canal (HP:0000402)1.72646449
103Medulloblastoma (HP:0002885)1.71967221
104Respiratory difficulties (HP:0002880)1.71889524
105Short thumb (HP:0009778)1.71564837
106High anterior hairline (HP:0009890)1.71402781
107Duplication of thumb phalanx (HP:0009942)1.71115273
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70543957
109Acute myeloid leukemia (HP:0004808)1.70332787
110Prominent metopic ridge (HP:0005487)1.70285150
111Vaginal fistula (HP:0004320)1.69919733
112Facial cleft (HP:0002006)1.69168481
113Missing ribs (HP:0000921)1.69154096
114Microvesicular hepatic steatosis (HP:0001414)1.69089998
115Thyroid carcinoma (HP:0002890)1.68957160
116Pancytopenia (HP:0001876)1.68948951
117Ependymoma (HP:0002888)1.68701452
118Aplasia involving forearm bones (HP:0009822)1.68245329
119Absent forearm bone (HP:0003953)1.68245329
120Meningioma (HP:0002858)1.68218934
121Abnormality of cochlea (HP:0000375)1.67807150
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67077258
123Acute encephalopathy (HP:0006846)1.65150123
124Abnormality of the carotid arteries (HP:0005344)1.64797283
125Abnormality of the incisor (HP:0000676)1.64490389
126Acute necrotizing encephalopathy (HP:0006965)1.64333537
127Slow-growing hair (HP:0002217)1.64165009
128Abnormality of hair growth rate (HP:0011363)1.64165009
129Combined immunodeficiency (HP:0005387)1.63743965
130Septate vagina (HP:0001153)1.63405470
131Glioma (HP:0009733)1.63323811
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61861341
133Uterine neoplasm (HP:0010784)1.61752218
134Shoulder girdle muscle weakness (HP:0003547)1.61191080
135Dandy-Walker malformation (HP:0001305)1.60953536
136Abnormality of the heme biosynthetic pathway (HP:0010472)1.60813573
137Intestinal atresia (HP:0011100)1.59902110
138Abnormality of chromosome segregation (HP:0002916)1.59721437
139Megaloblastic anemia (HP:0001889)1.59560346
140Selective tooth agenesis (HP:0001592)1.58942277
141Morphological abnormality of the inner ear (HP:0011390)1.57453704
142Severe visual impairment (HP:0001141)1.57307121
143Abnormal mitochondria in muscle tissue (HP:0008316)1.57259596
144Elfin facies (HP:0004428)1.57159545
145Abnormality of B cell number (HP:0010975)1.57054610
146Postnatal microcephaly (HP:0005484)1.56967580
147Acute lymphatic leukemia (HP:0006721)1.56539721
148Neoplasm of the pancreas (HP:0002894)1.56371334
149Adrenal hypoplasia (HP:0000835)1.56161359
150Tracheoesophageal fistula (HP:0002575)1.56110102
151Glossoptosis (HP:0000162)1.55895297
152Capillary hemangiomas (HP:0005306)1.55666089
153Spastic diplegia (HP:0001264)1.55533569
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54632295
155Abnormality of the phalanges of the hallux (HP:0010057)1.54592854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.95302046
2MKNK13.82577460
3MKNK23.38058269
4BRSK23.07306063
5PBK3.03261704
6CDC72.93692549
7BUB12.89503005
8CCNB12.83536875
9ZAK2.82037039
10SCYL22.59161749
11PLK42.56592661
12EIF2AK12.48910591
13WEE12.44059525
14VRK22.37533823
15ERBB32.30455270
16PLK32.07791549
17AKT32.02494580
18BRSK11.96121360
19TAF11.94079500
20MAP3K101.94003566
21VRK11.91467175
22STK161.87138268
23CASK1.82279215
24ACVR1B1.75425731
25SGK21.60113952
26EIF2AK21.58135401
27CLK11.50712971
28PLK11.47844791
29YES11.46209444
30CDK81.45376919
31EIF2AK31.39812179
32PRPF4B1.39217776
33BMPR21.38622289
34TSSK61.38547499
35PASK1.37215774
36STK241.36362236
37SIK31.33962867
38ATR1.27720011
39STK38L1.26408353
40TRIM281.26077008
41PNCK1.21183591
42NUAK11.19272130
43SMG11.18853879
44CHEK21.14781684
45LATS21.13814912
46AURKB1.13660655
47IRAK41.11464805
48NEK61.11391254
49PLK21.10978959
50NEK11.07173761
51TTK1.05909524
52MST1R1.05833855
53MAP3K141.04300152
54PAK41.00638977
55CDK60.99131900
56ERBB40.98970917
57LATS10.97399347
58STK40.94907728
59ALK0.94395904
60CDK70.92732225
61TXK0.90519165
62EEF2K0.87904574
63NME10.86144348
64AURKA0.85581908
65OBSCN0.84142456
66NEK20.83682103
67CDK120.82881178
68SGK30.82761164
69BMPR1B0.82217169
70MYLK0.81414720
71MAPK130.80949262
72TGFBR10.78893106
73SGK2230.78529263
74SGK4940.78529263
75MUSK0.78056387
76BRAF0.77680835
77FRK0.75986050
78DYRK30.75431094
79NEK90.75289600
80MET0.72222234
81RPS6KC10.71213635
82RPS6KL10.71213635
83ATM0.70132712
84RPS6KB10.69447046
85TEC0.68381816
86CSNK2A10.68212138
87RPS6KA60.68134068
88CHEK10.66503991
89MAP3K80.65539193
90TRPM70.64917608
91CDK30.64770048
92PIM10.64266984
93MAP2K70.63439676
94CSNK1E0.59816795
95CDK180.57819683
96CDK11A0.54319883
97TLK10.54092443
98CDK140.53638551
99RPS6KA40.53118331
100CDK150.52755086
101FGFR10.50574252
102BCR0.50205200
103CDK20.50189271
104CDK10.49759440
105CHUK0.49109795
106KSR10.48152881
107MAP3K90.45090975
108IRAK30.44637981
109CDK40.43705935
110MELK0.43315923
111ILK0.42773657
112CSNK1G10.42138783
113RPS6KB20.40694141
114ADRBK20.40086287
115PKN20.39657784
116DYRK20.39241468
117CSNK1G30.38819203
118TAOK20.37535540
119PRKDC0.35964027
120BRD40.35936696
121PAK20.35422961
122MINK10.34796382
123STK390.34318172
124PINK10.32013958
125LIMK10.31046313
126RPS6KA50.30502720
127* CSNK2A20.30502345
128AKT20.30360240
129MAP2K60.29400712
130STK30.28634663
131MST40.28087240
132PDK20.27953471
133MAPKAPK50.27645838
134CSNK1A1L0.27085265
135TESK10.26894446
136CDK90.26760453
137PIK3CA0.26439417
138MARK30.26057294
139TRIB30.25696374
140NME20.25439455
141MAPK140.23445641
142MAP3K120.23260803
143PIM20.22891380

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15282706
2Mismatch repair_Homo sapiens_hsa034304.56310824
3Base excision repair_Homo sapiens_hsa034103.63583562
4Homologous recombination_Homo sapiens_hsa034403.59500789
5RNA polymerase_Homo sapiens_hsa030203.20337466
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14989746
7Proteasome_Homo sapiens_hsa030503.09322623
8Nucleotide excision repair_Homo sapiens_hsa034203.08903832
9Spliceosome_Homo sapiens_hsa030403.07501904
10Cell cycle_Homo sapiens_hsa041102.93732685
11Fanconi anemia pathway_Homo sapiens_hsa034602.77597956
12RNA transport_Homo sapiens_hsa030132.50101101
13Pyrimidine metabolism_Homo sapiens_hsa002402.47959983
14Non-homologous end-joining_Homo sapiens_hsa034502.42351989
15Basal transcription factors_Homo sapiens_hsa030222.41388900
16RNA degradation_Homo sapiens_hsa030182.40291052
17One carbon pool by folate_Homo sapiens_hsa006702.27378362
18Ribosome_Homo sapiens_hsa030102.01404762
19mRNA surveillance pathway_Homo sapiens_hsa030151.86662807
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68733012
21Purine metabolism_Homo sapiens_hsa002301.63392625
22Protein export_Homo sapiens_hsa030601.46788526
23p53 signaling pathway_Homo sapiens_hsa041151.46083348
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27146870
25Biosynthesis of amino acids_Homo sapiens_hsa012301.19765770
26Huntingtons disease_Homo sapiens_hsa050161.17029154
27Pyruvate metabolism_Homo sapiens_hsa006201.15676866
28Parkinsons disease_Homo sapiens_hsa050121.06525106
29Epstein-Barr virus infection_Homo sapiens_hsa051691.02285652
30Herpes simplex infection_Homo sapiens_hsa051680.94385001
31Folate biosynthesis_Homo sapiens_hsa007900.92354532
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91662178
33Carbon metabolism_Homo sapiens_hsa012000.89493484
34Oocyte meiosis_Homo sapiens_hsa041140.88835463
35Systemic lupus erythematosus_Homo sapiens_hsa053220.84154220
36Thyroid cancer_Homo sapiens_hsa052160.83388961
37Steroid biosynthesis_Homo sapiens_hsa001000.83053275
38Arachidonic acid metabolism_Homo sapiens_hsa005900.80350293
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78252229
40Oxidative phosphorylation_Homo sapiens_hsa001900.75912147
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75381854
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75318353
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71224532
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70694463
45Propanoate metabolism_Homo sapiens_hsa006400.68503753
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67814563
47HTLV-I infection_Homo sapiens_hsa051660.66678933
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65485731
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65424365
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62430682
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.62283431
52N-Glycan biosynthesis_Homo sapiens_hsa005100.61134528
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60528063
54Viral carcinogenesis_Homo sapiens_hsa052030.60452001
55MicroRNAs in cancer_Homo sapiens_hsa052060.57390379
56Pentose phosphate pathway_Homo sapiens_hsa000300.57152524
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.56262063
58Chronic myeloid leukemia_Homo sapiens_hsa052200.55489132
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51698867
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50750966
61Measles_Homo sapiens_hsa051620.49161363
62Phototransduction_Homo sapiens_hsa047440.49081042
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48582647
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48439848
65Antigen processing and presentation_Homo sapiens_hsa046120.46309801
66Pancreatic cancer_Homo sapiens_hsa052120.45375544
67Alzheimers disease_Homo sapiens_hsa050100.43661482
68Glutathione metabolism_Homo sapiens_hsa004800.42895215
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41635819
70Alcoholism_Homo sapiens_hsa050340.41342940
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41070650
72Fatty acid elongation_Homo sapiens_hsa000620.40053224
73Legionellosis_Homo sapiens_hsa051340.39265085
74Bladder cancer_Homo sapiens_hsa052190.39021573
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38855966
76Basal cell carcinoma_Homo sapiens_hsa052170.38449510
77TGF-beta signaling pathway_Homo sapiens_hsa043500.37955410
78Melanoma_Homo sapiens_hsa052180.37288464
79Shigellosis_Homo sapiens_hsa051310.36977123
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36802665
81Primary immunodeficiency_Homo sapiens_hsa053400.36578281
82Hippo signaling pathway_Homo sapiens_hsa043900.33676741
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.33497449
84Small cell lung cancer_Homo sapiens_hsa052220.33326869
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33307153
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33045905
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32769582
88Autoimmune thyroid disease_Homo sapiens_hsa053200.32180976
89Influenza A_Homo sapiens_hsa051640.31689219
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31307839
91Galactose metabolism_Homo sapiens_hsa000520.31280947
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31076061
93Prostate cancer_Homo sapiens_hsa052150.30013604
94Sulfur relay system_Homo sapiens_hsa041220.29452137
95Hepatitis B_Homo sapiens_hsa051610.29379979
96Vitamin B6 metabolism_Homo sapiens_hsa007500.27806954
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27478459
98Allograft rejection_Homo sapiens_hsa053300.26804650
99Endometrial cancer_Homo sapiens_hsa052130.26223979
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25932881
101Metabolic pathways_Homo sapiens_hsa011000.25514902
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25377133
103Lysine degradation_Homo sapiens_hsa003100.24933773
104Wnt signaling pathway_Homo sapiens_hsa043100.23124901
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22079546
106Selenocompound metabolism_Homo sapiens_hsa004500.21649571
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.21069964
108Pathways in cancer_Homo sapiens_hsa052000.21068216
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20827397
110Renal cell carcinoma_Homo sapiens_hsa052110.20791681
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.19530599
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19487258
113Asthma_Homo sapiens_hsa053100.18809825
114Colorectal cancer_Homo sapiens_hsa052100.18468192
115FoxO signaling pathway_Homo sapiens_hsa040680.18441530
116Cardiac muscle contraction_Homo sapiens_hsa042600.18412396
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18109807
118Apoptosis_Homo sapiens_hsa042100.17215989
119Hematopoietic cell lineage_Homo sapiens_hsa046400.16349566
120Tight junction_Homo sapiens_hsa045300.15996481
121Notch signaling pathway_Homo sapiens_hsa043300.15465302
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14194426
123Non-small cell lung cancer_Homo sapiens_hsa052230.13783599
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13529956
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13273235
126Hedgehog signaling pathway_Homo sapiens_hsa043400.11947177
127Adherens junction_Homo sapiens_hsa045200.11250840
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10918551
129Viral myocarditis_Homo sapiens_hsa054160.09617814
130Proteoglycans in cancer_Homo sapiens_hsa052050.07364649

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