ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of uterine smooth muscle contraction (GO:0070474)	6.73343318
2	hyperosmotic salinity response (GO:0042538)	6.19039724
3	positive regulation of prostaglandin secretion (GO:0032308)	6.10446351
4	regulation of RIG-I signaling pathway (GO:0039535)	5.96286470
5	sequestering of actin monomers (GO:0042989)	5.56921680
6	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.40827481
7	regulation of female receptivity (GO:0045924)	5.12290221
8	sleep (GO:0030431)	5.03359479
9	mannosylation (GO:0097502)	4.98997441
10	regulation of prostaglandin secretion (GO:0032306)	4.96517039
11	regulation of uterine smooth muscle contraction (GO:0070472)	4.95220336
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.93599011
13	GPI anchor biosynthetic process (GO:0006506)	4.91326827
14	aggressive behavior (GO:0002118)	4.83344500
15	preassembly of GPI anchor in ER membrane (GO:0016254)	4.75864079
16	glial cell proliferation (GO:0014009)	4.56983581
17	GPI anchor metabolic process (GO:0006505)	4.56198270
18	pyrimidine nucleobase catabolic process (GO:0006208)	4.55786019
19	female mating behavior (GO:0060180)	4.38224211
20	behavioral response to ethanol (GO:0048149)	4.25701531
21	righting reflex (GO:0060013)	4.23351286
22	regulation of protein polyubiquitination (GO:1902914)	4.22375715
23	negative regulation of heart rate (GO:0010459)	4.13396849
24	limb bud formation (GO:0060174)	4.12580894
25	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	4.06724568
26	regulation of penile erection (GO:0060405)	4.02540440
27	gonadal mesoderm development (GO:0007506)	4.00633575
28	maternal behavior (GO:0042711)	3.99495932
29	drinking behavior (GO:0042756)	3.85625763
30	positive regulation of icosanoid secretion (GO:0032305)	3.84945524
31	maturation of SSU-rRNA (GO:0030490)	3.83711177
32	ATP synthesis coupled proton transport (GO:0015986)	3.77383478
33	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.77383478
34	positive regulation of TOR signaling (GO:0032008)	3.72195886
35	positive regulation of catecholamine secretion (GO:0033605)	3.68822870
36	somite development (GO:0061053)	3.66891329
37	adult feeding behavior (GO:0008343)	3.63211412
38	viral transcription (GO:0019083)	3.62993605
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.62588494
40	cornea development in camera-type eye (GO:0061303)	3.62186113
41	nucleobase catabolic process (GO:0046113)	3.59606799
42	tachykinin receptor signaling pathway (GO:0007217)	3.55365214
43	forebrain neuron differentiation (GO:0021879)	3.53862342
44	positive regulation of fatty acid transport (GO:2000193)	3.52661963
45	parental behavior (GO:0060746)	3.48634390
46	translational termination (GO:0006415)	3.46217748
47	neural tube formation (GO:0001841)	3.45672212
48	positive regulation of digestive system process (GO:0060456)	3.37804061
49	neurotransmitter catabolic process (GO:0042135)	3.34345090
50	negative regulation of digestive system process (GO:0060457)	3.20117566
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.18486163
52	protein localization to vacuole (GO:0072665)	3.13812323
53	protein localization to lysosome (GO:0061462)	3.13812323
54	C-terminal protein amino acid modification (GO:0018410)	3.12132694
55	viral genome replication (GO:0019079)	3.11796679
56	ribosomal small subunit assembly (GO:0000028)	3.09749251
57	cardiac right ventricle morphogenesis (GO:0003215)	3.08619607
58	translational elongation (GO:0006414)	3.07537483
59	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.07263167
60	activated T cell proliferation (GO:0050798)	3.03052648
61	C-terminal protein lipidation (GO:0006501)	3.01547115
62	glycolipid biosynthetic process (GO:0009247)	3.01480922
63	N-acetylglucosamine metabolic process (GO:0006044)	2.98035682
64	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.97511845
65	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.95899204
66	protein localization to synapse (GO:0035418)	2.93898674
67	type B pancreatic cell proliferation (GO:0044342)	2.92567908
68	regulation of urine volume (GO:0035809)	2.91414131
69	cotranslational protein targeting to membrane (GO:0006613)	2.91337517
70	positive regulation of heart rate (GO:0010460)	2.89278337
71	response to dietary excess (GO:0002021)	2.88084661
72	cullin deneddylation (GO:0010388)	2.87153284
73	electron transport chain (GO:0022900)	2.86871966
74	chaperone-mediated protein transport (GO:0072321)	2.84291786
75	spinal cord development (GO:0021510)	2.83919470
76	regulation of dopamine metabolic process (GO:0042053)	2.83770763
77	regulation of catecholamine metabolic process (GO:0042069)	2.83770763
78	protein targeting to ER (GO:0045047)	2.83620117
79	grooming behavior (GO:0007625)	2.82472060
80	regulation of icosanoid secretion (GO:0032303)	2.82284637
81	negative regulation of necroptotic process (GO:0060546)	2.80513046
82	negative regulation of glial cell proliferation (GO:0060253)	2.79046405
83	respiratory electron transport chain (GO:0022904)	2.77103043
84	hair cycle (GO:0042633)	2.73124044
85	molting cycle (GO:0042303)	2.73124044
86	lysine catabolic process (GO:0006554)	2.73024554
87	lysine metabolic process (GO:0006553)	2.73024554
88	protein localization to cilium (GO:0061512)	2.67560884
89	cellular protein complex disassembly (GO:0043624)	2.67212561
90	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.66835816
91	protein localization to endoplasmic reticulum (GO:0070972)	2.65066166
92	positive regulation of meiosis (GO:0045836)	2.65026646
93	positive regulation of smooth muscle contraction (GO:0045987)	2.64442946
94	protein complex disassembly (GO:0043241)	2.63404580
95	response to prostaglandin E (GO:0034695)	2.61065549
96	meiotic chromosome segregation (GO:0045132)	2.60272535
97	behavioral response to nicotine (GO:0035095)	2.59671473
98	NIK/NF-kappaB signaling (GO:0038061)	2.57960569
99	otic vesicle formation (GO:0030916)	2.57721378
100	behavioral defense response (GO:0002209)	2.50767415

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.12086476
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.74660156
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.38563763
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08474683
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.03745194
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.01037423
7	RNF2_27304074_Chip-Seq_NSC_Mouse	2.90802365
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.63475271
9	VDR_22108803_ChIP-Seq_LS180_Human	2.44289503
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.42090295
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38564688
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.37706392
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.34626267
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.23371384
15	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.21942073
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.21113262
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.12734882
18	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.12056972
19	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.08331433
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00702924
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.99986054
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.95001710
23	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.89998173
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.85825721
25	EWS_26573619_Chip-Seq_HEK293_Human	1.85073895
26	P300_19829295_ChIP-Seq_ESCs_Human	1.79890167
27	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.79441627
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74946525
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72323706
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.72228972
31	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.65795767
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.64877121
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.64877121
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.63662980
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.59494639
36	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.59494639
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.58984351
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58616384
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57642915
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57408080
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.56483624
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.55781806
43	FUS_26573619_Chip-Seq_HEK293_Human	1.54882961
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53175034
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.53166314
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52792696
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.51914852
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.50698718
49	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.50299633
50	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.49701147
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.49644073
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47308486
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45299724
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.44618148
55	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.44547487
56	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.43089144
57	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43030773
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38672626
59	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.36991153
60	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.36652842
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30679574
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.30495221
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29063228
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28300921
65	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25804672
66	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.22718396
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22021914
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21629873
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21420897
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19885343
71	NCOR_22424771_ChIP-Seq_293T_Human	1.19610241
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18486906
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15595523
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15375851
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.15375851
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14018748
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09388947
78	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08671471
79	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07429047
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07298795
81	AR_25329375_ChIP-Seq_VCAP_Human	1.04414007
82	VDR_23849224_ChIP-Seq_CD4+_Human	1.03657559
83	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03513822
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03142463
85	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02390398
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00575989
87	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98789985
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98066303
89	AR_20517297_ChIP-Seq_VCAP_Human	0.97872721
90	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.96919529
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96592254
92	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.95849779
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95729856
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95729856
95	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95709903
96	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.94686310
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94513999
98	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93773639
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.92546529
100	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92245833

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.99925727
2	MP0006276_abnormal_autonomic_nervous	4.54927410
3	MP0006292_abnormal_olfactory_placode	4.47297226
4	MP0000566_synostosis	3.26362472
5	MP0005645_abnormal_hypothalamus_physiol	3.23064942
6	MP0003880_abnormal_central_pattern	3.21042689
7	MP0001502_abnormal_circadian_rhythm	2.75445424
8	MP0003122_maternal_imprinting	2.57467889
9	MP0000778_abnormal_nervous_system	2.46357431
10	MP0000372_irregular_coat_pigmentation	2.39533496
11	MP0003011_delayed_dark_adaptation	2.22401409
12	MP0006072_abnormal_retinal_apoptosis	2.15239623
13	MP0002876_abnormal_thyroid_physiology	2.14233539
14	MP0003283_abnormal_digestive_organ	2.11481252
15	MP0001529_abnormal_vocalization	2.06213827
16	MP0004142_abnormal_muscle_tone	1.98702520
17	MP0000631_abnormal_neuroendocrine_gland	1.98657814
18	MP0003136_yellow_coat_color	1.88459832
19	MP0003191_abnormal_cellular_cholesterol	1.76303627
20	MP0002751_abnormal_autonomic_nervous	1.68223440
21	MP0001905_abnormal_dopamine_level	1.63454700
22	MP0004859_abnormal_synaptic_plasticity	1.61197416
23	MP0004270_analgesia	1.52622526
24	MP0003315_abnormal_perineum_morphology	1.51880214
25	MP0005084_abnormal_gallbladder_morpholo	1.49904332
26	MP0002102_abnormal_ear_morphology	1.46559801
27	MP0003718_maternal_effect	1.45922569
28	MP0003806_abnormal_nucleotide_metabolis	1.42818674
29	MP0008877_abnormal_DNA_methylation	1.41959577
30	MP0003121_genomic_imprinting	1.41818202
31	MP0004885_abnormal_endolymph	1.41488456
32	MP0002009_preneoplasia	1.39895808
33	MP0004742_abnormal_vestibular_system	1.36517933
34	MP0002064_seizures	1.36427917
35	MP0005253_abnormal_eye_physiology	1.34856550
36	MP0001440_abnormal_grooming_behavior	1.34762854
37	MP0004147_increased_porphyrin_level	1.34473023
38	MP0002234_abnormal_pharynx_morphology	1.32780227
39	MP0002557_abnormal_social/conspecific_i	1.31907686
40	MP0009745_abnormal_behavioral_response	1.26170343
41	MP0003119_abnormal_digestive_system	1.24992554
42	MP0000955_abnormal_spinal_cord	1.22013706
43	MP0005257_abnormal_intraocular_pressure	1.21310935
44	MP0002653_abnormal_ependyma_morphology	1.19512517
45	MP0002184_abnormal_innervation	1.19462309
46	MP0003635_abnormal_synaptic_transmissio	1.16546345
47	MP0002938_white_spotting	1.16281715
48	MP0000049_abnormal_middle_ear	1.12382854
49	MP0005386_behavior/neurological_phenoty	1.11192267
50	MP0004924_abnormal_behavior	1.11192267
51	MP0009046_muscle_twitch	1.07408234
52	MP0000534_abnormal_ureter_morphology	1.07324332
53	MP0005551_abnormal_eye_electrophysiolog	1.04342562
54	MP0005195_abnormal_posterior_eye	1.02679574
55	MP0003878_abnormal_ear_physiology	1.02605642
56	MP0005377_hearing/vestibular/ear_phenot	1.02605642
57	MP0002572_abnormal_emotion/affect_behav	1.01420477
58	MP0000647_abnormal_sebaceous_gland	1.01146700
59	MP0002736_abnormal_nociception_after	0.98494466
60	MP0004811_abnormal_neuron_physiology	0.98353971
61	MP0009053_abnormal_anal_canal	0.97538216
62	MP0008872_abnormal_physiological_respon	0.96569633
63	MP0002882_abnormal_neuron_morphology	0.96222922
64	MP0002909_abnormal_adrenal_gland	0.94747471
65	MP0002063_abnormal_learning/memory/cond	0.93824165
66	MP0005646_abnormal_pituitary_gland	0.92983131
67	MP0002272_abnormal_nervous_system	0.92354413
68	MP0002752_abnormal_somatic_nervous	0.92341227
69	MP0002067_abnormal_sensory_capabilities	0.90675435
70	MP0003938_abnormal_ear_development	0.90399291
71	MP0000026_abnormal_inner_ear	0.88713289
72	MP0001664_abnormal_digestion	0.88113529
73	MP0002160_abnormal_reproductive_system	0.87563177
74	MP0001501_abnormal_sleep_pattern	0.87116294
75	MP0000653_abnormal_sex_gland	0.85283915
76	MP0002210_abnormal_sex_determination	0.83666609
77	MP0001929_abnormal_gametogenesis	0.83225036
78	MP0000516_abnormal_urinary_system	0.81877287
79	MP0005367_renal/urinary_system_phenotyp	0.81877287
80	MP0000537_abnormal_urethra_morphology	0.80489567
81	MP0003638_abnormal_response/metabolism_	0.78649294
82	MP0004019_abnormal_vitamin_homeostasis	0.78365717
83	MP0008875_abnormal_xenobiotic_pharmacok	0.78277375
84	MP0005389_reproductive_system_phenotype	0.77840871
85	MP0003329_amyloid_beta_deposits	0.74887201
86	MP0001340_abnormal_eyelid_morphology	0.74247650
87	MP0003698_abnormal_male_reproductive	0.74178939
88	MP0010386_abnormal_urinary_bladder	0.72271630
89	MP0001970_abnormal_pain_threshold	0.72051000
90	MP0005391_vision/eye_phenotype	0.71996220
91	MP0001177_atelectasis	0.71585981
92	MP0001145_abnormal_male_reproductive	0.69866336
93	MP0002697_abnormal_eye_size	0.67692418
94	MP0000465_gastrointestinal_hemorrhage	0.66884577
95	MP0003866_abnormal_defecation	0.66751791
96	MP0003724_increased_susceptibility_to	0.65158264
97	MP0010030_abnormal_orbit_morphology	0.65099919
98	MP0001881_abnormal_mammary_gland	0.64067065
99	MP0000639_abnormal_adrenal_gland	0.63456920
100	MP0005423_abnormal_somatic_nervous	0.63161152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebellar dysplasia (HP:0007033)	4.05964172
2	Increased hepatocellular lipid droplets (HP:0006565)	3.87980511
3	Abnormality of the labia minora (HP:0012880)	3.61968514
4	Type II lissencephaly (HP:0007260)	3.54446170
5	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.50814471
6	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.50814471
7	Abnormality of the musculature of the pelvis (HP:0001469)	3.36188112
8	Abnormality of the hip-girdle musculature (HP:0001445)	3.36188112
9	Renal Fanconi syndrome (HP:0001994)	3.22768695
10	Acute necrotizing encephalopathy (HP:0006965)	3.22657398
11	Limb dystonia (HP:0002451)	3.19290913
12	Abnormal number of erythroid precursors (HP:0012131)	3.14575786
13	Mitochondrial inheritance (HP:0001427)	3.14266054
14	Lipid accumulation in hepatocytes (HP:0006561)	3.10968027
15	Limb-girdle muscle atrophy (HP:0003797)	3.08895023
16	Exertional dyspnea (HP:0002875)	2.97287814
17	Hypoplasia of the pons (HP:0012110)	2.95134221
18	Abnormality of cells of the erythroid lineage (HP:0012130)	2.94029042
19	Leukodystrophy (HP:0002415)	2.92614166
20	Progressive macrocephaly (HP:0004481)	2.91559672
21	Acute encephalopathy (HP:0006846)	2.91018397
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90697578
23	Shoulder girdle muscle weakness (HP:0003547)	2.88782408
24	Hyperglycinemia (HP:0002154)	2.87914945
25	Calf muscle hypertrophy (HP:0008981)	2.86619712
26	Abnormality of the pons (HP:0007361)	2.81021632
27	Megalencephaly (HP:0001355)	2.77945230
28	Congenital stationary night blindness (HP:0007642)	2.75467242
29	Abnormality of midbrain morphology (HP:0002418)	2.70889497
30	Molar tooth sign on MRI (HP:0002419)	2.70889497
31	Pachygyria (HP:0001302)	2.69077603
32	Increased intramyocellular lipid droplets (HP:0012240)	2.68799415
33	Pelvic girdle muscle weakness (HP:0003749)	2.59515011
34	Global brain atrophy (HP:0002283)	2.56131379
35	Pancreatic fibrosis (HP:0100732)	2.54878646
36	Generalized aminoaciduria (HP:0002909)	2.54385499
37	True hermaphroditism (HP:0010459)	2.53555180
38	Muscle hypertrophy of the lower extremities (HP:0008968)	2.52656053
39	Large eyes (HP:0001090)	2.48268062
40	Increased CSF lactate (HP:0002490)	2.48117255
41	Myokymia (HP:0002411)	2.46320918
42	Septo-optic dysplasia (HP:0100842)	2.40671047
43	Metaphyseal dysplasia (HP:0100255)	2.36778240
44	Hypoplastic pelvis (HP:0008839)	2.34935585
45	Hypoventilation (HP:0002791)	2.34266146
46	3-Methylglutaconic aciduria (HP:0003535)	2.32284773
47	Lissencephaly (HP:0001339)	2.31453015
48	Poor suck (HP:0002033)	2.31053791
49	Hepatocellular necrosis (HP:0001404)	2.30691667
50	Abnormality of the anterior horn cell (HP:0006802)	2.27320836
51	Degeneration of anterior horn cells (HP:0002398)	2.27320836
52	Hyperphosphaturia (HP:0003109)	2.26362527
53	Nephronophthisis (HP:0000090)	2.21758638
54	Amniotic constriction ring (HP:0009775)	2.12335162
55	Abnormality of placental membranes (HP:0011409)	2.12335162
56	Reticulocytopenia (HP:0001896)	2.10652812
57	Growth hormone excess (HP:0000845)	2.09111904
58	Optic nerve hypoplasia (HP:0000609)	2.08960021
59	Synostosis involving the elbow (HP:0003938)	2.08864494
60	Humeroradial synostosis (HP:0003041)	2.08864494
61	Patellar aplasia (HP:0006443)	2.08805603
62	Pancreatic cysts (HP:0001737)	2.08299539
63	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.01876033
64	Abnormality of urine glucose concentration (HP:0011016)	2.01573608
65	Glycosuria (HP:0003076)	2.01573608
66	Hepatic necrosis (HP:0002605)	2.01423597
67	Aplasia/Hypoplasia of the patella (HP:0006498)	2.00555928
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00351954
69	Agitation (HP:0000713)	2.00058113
70	Maternal diabetes (HP:0009800)	1.99610321
71	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.99400565
72	Broad-based gait (HP:0002136)	1.95869975
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95866683
74	Optic disc pallor (HP:0000543)	1.95365197
75	Abnormality of renal resorption (HP:0011038)	1.94576325
76	Hypercortisolism (HP:0001578)	1.92524694
77	Chronic hepatic failure (HP:0100626)	1.92430529
78	Abnormal sex determination (HP:0012244)	1.90569130
79	Sex reversal (HP:0012245)	1.90569130
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90232942
81	Increased muscle lipid content (HP:0009058)	1.90174386
82	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.89035924
83	Hypothermia (HP:0002045)	1.89018545
84	Hemiplegia (HP:0002301)	1.88803660
85	Abnormality of dental color (HP:0011073)	1.87894701
86	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84821396
87	Stenosis of the external auditory canal (HP:0000402)	1.84670374
88	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.84606992
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84218870
90	Abnormality of the renal medulla (HP:0100957)	1.83419000
91	Respiratory difficulties (HP:0002880)	1.80857416
92	Spastic paraparesis (HP:0002313)	1.80762051
93	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.79949592
94	Polyphagia (HP:0002591)	1.78234859
95	Exocrine pancreatic insufficiency (HP:0001738)	1.77273232
96	Hypoplasia of the brainstem (HP:0002365)	1.77029895
97	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.77029895
98	Absent septum pellucidum (HP:0001331)	1.75323803
99	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74825989
100	Parakeratosis (HP:0001036)	1.74525623

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.21806322
2	MAP4K2	3.81060464
3	EPHA3	3.34719110
4	CDK19	2.60387707
5	CASK	2.59821139
6	TNIK	2.59596178
7	MARK1	2.57582104
8	MAP3K12	2.50780173
9	DYRK2	2.37339693
10	NUAK1	2.36113493
11	TLK1	2.17465114
12	ERBB3	2.14316098
13	TRIM28	2.11385923
14	ARAF	1.93974253
15	UHMK1	1.90113044
16	CSNK1G2	1.89729529
17	LATS2	1.88911244
18	DYRK1B	1.66795295
19	WNK3	1.59853598
20	PINK1	1.58096940
21	FLT3	1.54172818
22	ADRBK2	1.49768532
23	TXK	1.45671400
24	ZAK	1.45437419
25	VRK1	1.43297937
26	TYRO3	1.41992745
27	BCR	1.37391154
28	CSNK1G3	1.35324063
29	BCKDK	1.32347144
30	PLK2	1.30014499
31	BMPR2	1.27383044
32	MAP2K7	1.25585607
33	STK16	1.18342034
34	FES	1.12502039
35	MOS	1.11465620
36	EPHB2	1.11011384
37	NTRK1	1.07130072
38	MAPK13	1.06738632
39	MAP3K13	1.05248360
40	ILK	0.97324045
41	CSNK1G1	0.97188062
42	WNK1	0.96009439
43	CDK6	0.95426929
44	RPS6KA5	0.95218695
45	NTRK2	0.88652437
46	TESK2	0.88045226
47	SIK3	0.83028141
48	CSNK1A1L	0.81235536
49	OXSR1	0.79839876
50	MAP3K4	0.79387482
51	PHKG1	0.73722549
52	PHKG2	0.73722549
53	WNK4	0.70709315
54	CHEK2	0.68367581
55	PIM2	0.67263278
56	CDK12	0.65519659
57	PKN1	0.65289596
58	JAK3	0.61681787
59	PIM1	0.60502389
60	EIF2AK3	0.60261944
61	EPHA4	0.59526015
62	AURKA	0.58548440
63	BMPR1B	0.56879367
64	KDR	0.55474564
65	KSR1	0.54762592
66	CSNK2A1	0.54067078
67	CSF1R	0.51986436
68	HIPK2	0.51652106
69	MINK1	0.50951552
70	LMTK2	0.50872636
71	DAPK3	0.49988411
72	MYLK	0.48383574
73	FGFR2	0.48059575
74	GRK1	0.42790595
75	CSNK1A1	0.42527572
76	NLK	0.42185820
77	PIK3CA	0.41784605
78	PRKCQ	0.40785213
79	GRK5	0.40339047
80	CSNK1E	0.40242174
81	BUB1	0.40081527
82	INSRR	0.39771742
83	FRK	0.38479914
84	PRKD3	0.38181649
85	MAP3K9	0.33844209
86	KIT	0.33357838
87	MAPK15	0.33300641
88	DYRK3	0.33054939
89	CSNK1D	0.32675682
90	PAK1	0.32566831
91	GRK7	0.32406046
92	JAK2	0.32379664
93	CSNK2A2	0.32348738
94	PRKACA	0.31700911
95	BLK	0.31438487
96	CDK5	0.31361538
97	PRKCD	0.30584550
98	MST4	0.30442210
99	AKT2	0.30227119
100	MATK	0.29658331

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.95629443
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.65408616
3	Ribosome_Homo sapiens_hsa03010	3.64580302
4	Asthma_Homo sapiens_hsa05310	3.22281463
5	Parkinsons disease_Homo sapiens_hsa05012	3.15328856
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.63876445
7	Basal transcription factors_Homo sapiens_hsa03022	2.52591085
8	Alzheimers disease_Homo sapiens_hsa05010	2.31681913
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.18750947
10	Allograft rejection_Homo sapiens_hsa05330	2.16665823
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.16053403
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.10815164
13	Huntingtons disease_Homo sapiens_hsa05016	2.06785964
14	Phototransduction_Homo sapiens_hsa04744	2.06561223
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.06058926
16	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.05713643
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.99248409
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93938407
19	RNA polymerase_Homo sapiens_hsa03020	1.81439321
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78051125
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.68607837
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.62181380
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.60897630
24	Protein export_Homo sapiens_hsa03060	1.59819645
25	Proteasome_Homo sapiens_hsa03050	1.50169966
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.49941289
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.40110441
28	Viral myocarditis_Homo sapiens_hsa05416	1.36760129
29	Alcoholism_Homo sapiens_hsa05034	1.29980826
30	Nicotine addiction_Homo sapiens_hsa05033	1.28009427
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23658890
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.19357728
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15526078
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08375427
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02961126
36	Sulfur metabolism_Homo sapiens_hsa00920	1.02410663
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.01577366
38	Olfactory transduction_Homo sapiens_hsa04740	0.92085729
39	Circadian entrainment_Homo sapiens_hsa04713	0.90378375
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82825774
41	GABAergic synapse_Homo sapiens_hsa04727	0.82824819
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79197536
43	Antigen processing and presentation_Homo sapiens_hsa04612	0.78180253
44	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.77778112
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.77708915
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76562278
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74320389
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72613484
49	Toxoplasmosis_Homo sapiens_hsa05145	0.71720813
50	Morphine addiction_Homo sapiens_hsa05032	0.71180344
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71145703
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.70403532
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69904884
54	Serotonergic synapse_Homo sapiens_hsa04726	0.68646067
55	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68636845
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67718198
57	Cholinergic synapse_Homo sapiens_hsa04725	0.66956050
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.66943963
59	Spliceosome_Homo sapiens_hsa03040	0.66362235
60	Salivary secretion_Homo sapiens_hsa04970	0.64948943
61	Butanoate metabolism_Homo sapiens_hsa00650	0.64200032
62	Retinol metabolism_Homo sapiens_hsa00830	0.63379999
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63095426
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61103115
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60592150
66	Herpes simplex infection_Homo sapiens_hsa05168	0.60169282
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58380070
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56828675
69	Leishmaniasis_Homo sapiens_hsa05140	0.56548706
70	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.54269192
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50478473
72	Phagosome_Homo sapiens_hsa04145	0.50461513
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50351404
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48797858
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46109656
76	RNA degradation_Homo sapiens_hsa03018	0.45851061
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45310377
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.45128573
79	Gastric acid secretion_Homo sapiens_hsa04971	0.45034703
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44095731
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43000664
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.42310951
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42181192
84	Metabolic pathways_Homo sapiens_hsa01100	0.40833437
85	Cocaine addiction_Homo sapiens_hsa05030	0.40443801
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39285768
87	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.37296688
88	Apoptosis_Homo sapiens_hsa04210	0.37035036
89	Axon guidance_Homo sapiens_hsa04360	0.36495230
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35094197
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34470106
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.33336233
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.33063436
94	Insulin secretion_Homo sapiens_hsa04911	0.32628275
95	Amphetamine addiction_Homo sapiens_hsa05031	0.31715109
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30200253
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27553519
98	Propanoate metabolism_Homo sapiens_hsa00640	0.27529527
99	Tuberculosis_Homo sapiens_hsa05152	0.25311119
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22918146

CBX3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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