CBX3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.72057934
2presynaptic membrane assembly (GO:0097105)6.38648216
3nucleobase catabolic process (GO:0046113)5.42087270
4regulation of synapse structural plasticity (GO:0051823)5.33805678
5presynaptic membrane organization (GO:0097090)5.18911358
6replication fork processing (GO:0031297)5.17426052
7DNA double-strand break processing (GO:0000729)4.59174536
8positive regulation of amino acid transport (GO:0051957)4.51863387
9protein polyglutamylation (GO:0018095)4.25218158
10olfactory bulb development (GO:0021772)4.25159936
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.05479673
12spinal cord development (GO:0021510)3.99182395
13limb bud formation (GO:0060174)3.90071641
14negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79221139
15negative regulation of appetite (GO:0032099)3.79033809
16negative regulation of response to food (GO:0032096)3.79033809
17resolution of meiotic recombination intermediates (GO:0000712)3.77098940
18response to pheromone (GO:0019236)3.76822129
19negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.76789490
20retinal cone cell development (GO:0046549)3.76681750
21negative regulation of heart rate (GO:0010459)3.75711467
22neural tube formation (GO:0001841)3.62645411
23neuron cell-cell adhesion (GO:0007158)3.58591974
24retinal ganglion cell axon guidance (GO:0031290)3.56398153
25cilium morphogenesis (GO:0060271)3.51987656
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50310035
27central nervous system projection neuron axonogenesis (GO:0021952)3.45269330
28regulation of DNA endoreduplication (GO:0032875)3.44708687
29regulation of timing of cell differentiation (GO:0048505)3.40779689
30tachykinin receptor signaling pathway (GO:0007217)3.35525837
31regulation of cilium movement (GO:0003352)3.30419083
32postreplication repair (GO:0006301)3.27449021
33negative regulation of axon guidance (GO:1902668)3.24972460
34gamma-aminobutyric acid transport (GO:0015812)3.23230798
35postsynaptic membrane organization (GO:0001941)3.21983460
36epithelial cilium movement (GO:0003351)3.19683819
37regulation of development, heterochronic (GO:0040034)3.19535593
38neurotransmitter-gated ion channel clustering (GO:0072578)3.17690282
39glycosphingolipid biosynthetic process (GO:0006688)3.16635328
40positive regulation of male gonad development (GO:2000020)3.13044012
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.08539279
42central nervous system neuron axonogenesis (GO:0021955)3.08100630
43acrosome assembly (GO:0001675)3.07748771
44positive regulation of cardiac muscle cell differentiation (GO:2000727)3.02507207
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02382668
46water-soluble vitamin biosynthetic process (GO:0042364)3.02150059
47protein K11-linked deubiquitination (GO:0035871)3.00912615
48ganglion development (GO:0061548)2.99112787
49regulation of glutamate secretion (GO:0014048)2.97603453
50DNA-dependent DNA replication (GO:0006261)2.97478031
51negative regulation of DNA-dependent DNA replication (GO:2000104)2.96960033
52fucose catabolic process (GO:0019317)2.95756638
53L-fucose metabolic process (GO:0042354)2.95756638
54L-fucose catabolic process (GO:0042355)2.95756638
55microtubule depolymerization (GO:0007019)2.95025610
56positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93190669
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86764944
58cerebral cortex radially oriented cell migration (GO:0021799)2.85520934
59regulation of centriole replication (GO:0046599)2.83875475
60cilium organization (GO:0044782)2.83245030
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.80196752
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79890748
63nonmotile primary cilium assembly (GO:0035058)2.79622129
64vocalization behavior (GO:0071625)2.78399149
65cilium assembly (GO:0042384)2.76769543
66neuron recognition (GO:0008038)2.76448629
67kinetochore assembly (GO:0051382)2.75965754
68regulation of sarcomere organization (GO:0060297)2.75940708
69centriole replication (GO:0007099)2.75902096
70smoothened signaling pathway (GO:0007224)2.75730085
71proteasome assembly (GO:0043248)2.75292991
72DNA catabolic process, exonucleolytic (GO:0000738)2.74919577
73intraciliary transport (GO:0042073)2.71678367
74appendage development (GO:0048736)2.71555434
75limb development (GO:0060173)2.71555434
76mechanosensory behavior (GO:0007638)2.71432292
77histone H2A acetylation (GO:0043968)2.69513781
78microtubule polymerization or depolymerization (GO:0031109)2.68680313
79glutamate receptor signaling pathway (GO:0007215)2.66716769
80regulation of axon guidance (GO:1902667)2.66651801
81regulation of hexokinase activity (GO:1903299)2.66321226
82regulation of glucokinase activity (GO:0033131)2.66321226
83cell morphogenesis involved in neuron differentiation (GO:0048667)2.65489957
84cilium movement (GO:0003341)2.64129862
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.62185727
86respiratory chain complex IV assembly (GO:0008535)2.61113005
87lymphangiogenesis (GO:0001946)2.58205132
88regulation of meiosis I (GO:0060631)2.56172850
89regulation of male gonad development (GO:2000018)2.55640473
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55472470
91dendrite morphogenesis (GO:0048813)2.54557985
92auditory behavior (GO:0031223)2.53506719
93kinetochore organization (GO:0051383)2.51414597
94neuron fate determination (GO:0048664)2.50668125
95axonal fasciculation (GO:0007413)2.49835344
96negative regulation of astrocyte differentiation (GO:0048712)2.49254182
97translesion synthesis (GO:0019985)2.48464701
98cullin deneddylation (GO:0010388)2.47733982
99monoubiquitinated protein deubiquitination (GO:0035520)2.45819602
100ionotropic glutamate receptor signaling pathway (GO:0035235)2.45643454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.96718808
2GBX2_23144817_ChIP-Seq_PC3_Human3.78811347
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.53497616
4ZNF274_21170338_ChIP-Seq_K562_Hela3.25561979
5IGF1R_20145208_ChIP-Seq_DFB_Human3.14213446
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.04704562
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.97314941
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.69097083
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64802084
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55559871
11P300_19829295_ChIP-Seq_ESCs_Human2.32594513
12TAF15_26573619_Chip-Seq_HEK293_Human2.23083925
13FUS_26573619_Chip-Seq_HEK293_Human2.21611717
14EWS_26573619_Chip-Seq_HEK293_Human2.19915212
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14747880
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10835693
17VDR_22108803_ChIP-Seq_LS180_Human2.10206814
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05853154
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98326076
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95416332
21ER_23166858_ChIP-Seq_MCF-7_Human1.89672556
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89642970
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88034728
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87614418
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86840003
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84842060
27SMAD4_21799915_ChIP-Seq_A2780_Human1.83744758
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74672942
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.73601174
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.71906348
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70566918
32IRF1_19129219_ChIP-ChIP_H3396_Human1.69911864
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66065621
34EZH2_22144423_ChIP-Seq_EOC_Human1.59088903
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54345011
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54118705
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53623257
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51947625
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.51691710
40AR_25329375_ChIP-Seq_VCAP_Human1.51496852
41BCAT_22108803_ChIP-Seq_LS180_Human1.48726542
42AR_21572438_ChIP-Seq_LNCaP_Human1.48439024
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45876393
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45790431
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45405591
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43545309
47CBP_20019798_ChIP-Seq_JUKART_Human1.42130205
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42130205
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.41803077
50STAT3_23295773_ChIP-Seq_U87_Human1.41456313
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40236472
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40236472
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39615999
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36263223
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35830486
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.30748275
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.30152785
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30035067
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.29649156
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.27322872
61TCF4_23295773_ChIP-Seq_U87_Human1.26385502
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25840533
63TCF4_22108803_ChIP-Seq_LS180_Human1.25454316
64ELK1_19687146_ChIP-ChIP_HELA_Human1.24452388
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23538005
66RUNX2_22187159_ChIP-Seq_PCA_Human1.21930430
67RNF2_27304074_Chip-Seq_NSC_Mouse1.20756454
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18526343
69SOX9_26525672_Chip-Seq_HEART_Mouse1.18023933
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17925158
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.17686202
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17463612
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15378088
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15133880
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14385967
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13908345
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13241991
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11269512
79P53_22387025_ChIP-Seq_ESCs_Mouse1.11076068
80JUN_21703547_ChIP-Seq_K562_Human1.11054843
81TP53_22573176_ChIP-Seq_HFKS_Human1.11044685
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10338901
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.09416592
84REST_21632747_ChIP-Seq_MESCs_Mouse1.08923619
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.08890393
86MYC_18940864_ChIP-ChIP_HL60_Human1.07691364
87SOX2_19829295_ChIP-Seq_ESCs_Human1.06891159
88NANOG_19829295_ChIP-Seq_ESCs_Human1.06891159
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05299176
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04974684
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.04047139
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03583480
93KDM2B_26808549_Chip-Seq_REH_Human1.03077254
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02951625
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02911474
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.02488178
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.02435687
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.01219256
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00715189
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.00482636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.86941158
2MP0000569_abnormal_digit_pigmentation2.93964923
3MP0001968_abnormal_touch/_nociception2.79237441
4MP0008058_abnormal_DNA_repair2.67665168
5MP0003880_abnormal_central_pattern2.62283727
6MP0005367_renal/urinary_system_phenotyp2.43670066
7MP0000516_abnormal_urinary_system2.43670066
8MP0005551_abnormal_eye_electrophysiolog2.17865651
9MP0000778_abnormal_nervous_system2.09222979
10MP0003787_abnormal_imprinting2.07921613
11MP0008789_abnormal_olfactory_epithelium2.07230637
12MP0002751_abnormal_autonomic_nervous2.03305686
13MP0002102_abnormal_ear_morphology1.94602538
14MP0008877_abnormal_DNA_methylation1.94512766
15MP0006072_abnormal_retinal_apoptosis1.84195710
16MP0003121_genomic_imprinting1.83569237
17MP0001486_abnormal_startle_reflex1.83255566
18MP0002653_abnormal_ependyma_morphology1.68211618
19MP0004147_increased_porphyrin_level1.67223606
20MP0002938_white_spotting1.66844419
21MP0004270_analgesia1.66705839
22MP0003136_yellow_coat_color1.66168757
23MP0004742_abnormal_vestibular_system1.61323011
24MP0009046_muscle_twitch1.60960763
25MP0002735_abnormal_chemical_nociception1.58571912
26MP0002733_abnormal_thermal_nociception1.58421052
27MP0005499_abnormal_olfactory_system1.57260284
28MP0005394_taste/olfaction_phenotype1.57260284
29MP0001984_abnormal_olfaction1.56712296
30MP0005253_abnormal_eye_physiology1.54026237
31MP0005423_abnormal_somatic_nervous1.52168215
32MP0003937_abnormal_limbs/digits/tail_de1.49394372
33MP0002734_abnormal_mechanical_nocicepti1.48926381
34MP0005187_abnormal_penis_morphology1.48599458
35MP0010368_abnormal_lymphatic_system1.45481999
36MP0004142_abnormal_muscle_tone1.42851134
37MP0002272_abnormal_nervous_system1.41704657
38MP0005248_abnormal_Harderian_gland1.40424450
39MP0006292_abnormal_olfactory_placode1.39871439
40MP0003635_abnormal_synaptic_transmissio1.39826083
41MP0009745_abnormal_behavioral_response1.38927970
42MP0001970_abnormal_pain_threshold1.37300456
43MP0001529_abnormal_vocalization1.36288196
44MP0002572_abnormal_emotion/affect_behav1.36023675
45MP0002067_abnormal_sensory_capabilities1.35492220
46MP0004885_abnormal_endolymph1.33658111
47MP0010094_abnormal_chromosome_stability1.33515260
48MP0009697_abnormal_copulation1.31501816
49MP0002234_abnormal_pharynx_morphology1.31185155
50MP0002184_abnormal_innervation1.29588061
51MP0008057_abnormal_DNA_replication1.29329556
52MP0000427_abnormal_hair_cycle1.28463813
53MP0000631_abnormal_neuroendocrine_gland1.27117281
54MP0003890_abnormal_embryonic-extraembry1.25103819
55MP0002638_abnormal_pupillary_reflex1.25058254
56MP0002233_abnormal_nose_morphology1.24278637
57MP0000955_abnormal_spinal_cord1.23970949
58MP0004133_heterotaxia1.23808986
59MP0001986_abnormal_taste_sensitivity1.23782820
60MP0000049_abnormal_middle_ear1.21120472
61MP0005171_absent_coat_pigmentation1.18810639
62MP0001177_atelectasis1.17225147
63MP0002095_abnormal_skin_pigmentation1.16408356
64MP0002063_abnormal_learning/memory/cond1.16321308
65MP0001485_abnormal_pinna_reflex1.15554496
66MP0003646_muscle_fatigue1.15484614
67MP0006276_abnormal_autonomic_nervous1.15457020
68MP0005386_behavior/neurological_phenoty1.14297960
69MP0004924_abnormal_behavior1.14297960
70MP0004859_abnormal_synaptic_plasticity1.13792495
71MP0002557_abnormal_social/conspecific_i1.11880727
72MP0003122_maternal_imprinting1.11311915
73MP0003385_abnormal_body_wall1.10718396
74MP0002064_seizures1.08619404
75MP0004043_abnormal_pH_regulation1.05770022
76MP0002837_dystrophic_cardiac_calcinosis1.05279101
77MP0002752_abnormal_somatic_nervous1.04106979
78MP0000467_abnormal_esophagus_morphology1.03175626
79MP0005646_abnormal_pituitary_gland1.01103819
80MP0004811_abnormal_neuron_physiology0.95887160
81MP0000026_abnormal_inner_ear0.94088719
82MP0002882_abnormal_neuron_morphology0.94076339
83MP0002282_abnormal_trachea_morphology0.93007051
84MP0005195_abnormal_posterior_eye0.92284236
85MP0001501_abnormal_sleep_pattern0.92205910
86MP0004215_abnormal_myocardial_fiber0.90920685
87MP0001188_hyperpigmentation0.88724072
88MP0003861_abnormal_nervous_system0.88471608
89MP0002152_abnormal_brain_morphology0.88471174
90MP0003755_abnormal_palate_morphology0.88407841
91MP0005174_abnormal_tail_pigmentation0.86962602
92MP0001929_abnormal_gametogenesis0.86823567
93MP0003868_abnormal_feces_composition0.86201364
94MP0002210_abnormal_sex_determination0.84695233
95MP0002277_abnormal_respiratory_mucosa0.84389251
96MP0008775_abnormal_heart_ventricle0.83136786
97MP0000647_abnormal_sebaceous_gland0.82489302
98MP0003698_abnormal_male_reproductive0.82443397
99MP0009764_decreased_sensitivity_to0.80361634
100MP0003119_abnormal_digestive_system0.80023684

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)3.95150479
2Hyperventilation (HP:0002883)3.62530974
3Hyperglycinemia (HP:0002154)3.46663547
4Tubulointerstitial nephritis (HP:0001970)3.37776130
5Methylmalonic acidemia (HP:0002912)3.23073017
6True hermaphroditism (HP:0010459)3.09188909
7Neoplasm of the adrenal cortex (HP:0100641)3.05385054
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.00480992
9Colon cancer (HP:0003003)2.96196472
10Stomach cancer (HP:0012126)2.93841937
11Hemiparesis (HP:0001269)2.90745664
12Molar tooth sign on MRI (HP:0002419)2.90668426
13Abnormality of midbrain morphology (HP:0002418)2.90668426
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.90152784
15Nephronophthisis (HP:0000090)2.89462801
16Progressive inability to walk (HP:0002505)2.78222640
17Glioma (HP:0009733)2.75440456
18Inability to walk (HP:0002540)2.72210167
19Abnormality of the labia minora (HP:0012880)2.69253611
20Neoplasm of the oral cavity (HP:0100649)2.68714273
21Drooling (HP:0002307)2.68007853
22Pancreatic fibrosis (HP:0100732)2.65944859
23Volvulus (HP:0002580)2.64394263
24Pancreatic cysts (HP:0001737)2.61453538
25Astrocytoma (HP:0009592)2.60983918
26Abnormality of the astrocytes (HP:0100707)2.60983918
27Papillary thyroid carcinoma (HP:0002895)2.59135054
28Adactyly (HP:0009776)2.58707176
29Short tibia (HP:0005736)2.54952329
30Excessive salivation (HP:0003781)2.44003178
31Lissencephaly (HP:0001339)2.42367343
32Bony spicule pigmentary retinopathy (HP:0007737)2.42037594
33Medial flaring of the eyebrow (HP:0010747)2.39639520
34Methylmalonic aciduria (HP:0012120)2.38002294
35Abnormality of the renal medulla (HP:0100957)2.36489635
36Epidermoid cyst (HP:0200040)2.34660685
37Pachygyria (HP:0001302)2.29060099
38Type II lissencephaly (HP:0007260)2.25967963
39Optic nerve hypoplasia (HP:0000609)2.22346791
40Absent/shortened dynein arms (HP:0200106)2.22165164
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.22165164
42Small hand (HP:0200055)2.21252426
43Epileptic encephalopathy (HP:0200134)2.20193274
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.19751029
45Abnormal respiratory motile cilium physiology (HP:0012261)2.15167257
46Oligodactyly (hands) (HP:0001180)2.15157465
47Hepatoblastoma (HP:0002884)2.10487826
48Split foot (HP:0001839)2.08548030
49Febrile seizures (HP:0002373)2.08501782
50Abnormality of vitamin B metabolism (HP:0004340)2.06998781
51Absent speech (HP:0001344)2.05632283
52Cortical dysplasia (HP:0002539)2.04549361
53Abnormal hair whorl (HP:0010721)2.02807365
54Intestinal atresia (HP:0011100)2.02508471
55Congenital stationary night blindness (HP:0007642)2.00635142
56Septo-optic dysplasia (HP:0100842)2.00081697
57Gait imbalance (HP:0002141)1.99628180
58Aplasia/Hypoplasia of the uvula (HP:0010293)1.95749667
59Horizontal nystagmus (HP:0000666)1.92952579
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92922096
61Broad-based gait (HP:0002136)1.91785073
62Congenital primary aphakia (HP:0007707)1.91071092
63Narrow forehead (HP:0000341)1.89402530
64Attenuation of retinal blood vessels (HP:0007843)1.88965357
65Rhinitis (HP:0012384)1.88815530
66Progressive microcephaly (HP:0000253)1.88454707
67Abnormal ciliary motility (HP:0012262)1.88435864
68Focal motor seizures (HP:0011153)1.87970646
69Genital tract atresia (HP:0001827)1.87964166
70Neoplasm of the adrenal gland (HP:0100631)1.87153163
71Abnormality of glycine metabolism (HP:0010895)1.85471060
72Abnormality of serine family amino acid metabolism (HP:0010894)1.85471060
73Abolished electroretinogram (ERG) (HP:0000550)1.85270798
74Postaxial hand polydactyly (HP:0001162)1.82426827
75Impaired social interactions (HP:0000735)1.81964012
76Abnormal social behavior (HP:0012433)1.81964012
77Cupped ear (HP:0000378)1.81835351
78Abnormal rod and cone electroretinograms (HP:0008323)1.81717165
79Thyroid carcinoma (HP:0002890)1.81071905
80Medulloblastoma (HP:0002885)1.80485475
81Ependymoma (HP:0002888)1.79498982
82Tubular atrophy (HP:0000092)1.76680758
83Median cleft lip (HP:0000161)1.76578678
84Abnormality of chromosome stability (HP:0003220)1.76236287
85Meckel diverticulum (HP:0002245)1.74712664
86Increased CSF lactate (HP:0002490)1.73303597
87Hypoplasia of the pons (HP:0012110)1.73081205
88Fair hair (HP:0002286)1.72385568
89Abnormal respiratory motile cilium morphology (HP:0005938)1.71815295
90Abnormal respiratory epithelium morphology (HP:0012253)1.71815295
91Tubulointerstitial abnormality (HP:0001969)1.69770633
92Widely spaced teeth (HP:0000687)1.69291654
93Vaginal atresia (HP:0000148)1.68300475
94Poor eye contact (HP:0000817)1.67783723
95Constricted visual fields (HP:0001133)1.67485086
96Supernumerary spleens (HP:0009799)1.66935484
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.65826039
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.65309104
99Hypsarrhythmia (HP:0002521)1.64506090
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64428713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.99609656
2WNK33.68630782
3BMPR1B3.46704236
4MARK13.46547829
5CASK3.35425288
6MAPK133.06996177
7ZAK2.73393555
8PNCK2.58760519
9MKNK22.41290846
10CCNB12.39507504
11NUAK12.33797628
12DYRK22.22226978
13YES11.89557010
14MAP3K41.86245712
15WEE11.64549266
16NEK11.58878703
17PLK21.52714594
18PLK41.50549738
19MKNK11.50139650
20TNIK1.42309373
21CSNK1G21.41427958
22OXSR11.39026177
23PLK31.37241912
24CSNK1G11.34374287
25MAP4K21.30633630
26CSNK1G31.29702591
27MAP2K71.28757435
28TGFBR11.24652121
29NTRK21.24602119
30STK391.21493301
31GRK11.20374669
32CSNK1A1L1.19155755
33TRIM281.15766991
34EIF2AK11.13700238
35ACVR1B1.10025518
36VRK11.08746103
37CAMK1G1.08104936
38FGFR21.03091617
39EIF2AK31.02857074
40TTK1.02654303
41PRKCG1.01485262
42ADRBK20.98606043
43PRKCE0.96919031
44EPHB20.92916452
45ERBB30.89638199
46EPHA40.88778040
47CAMK1D0.88457128
48PAK30.87790257
49CAMKK20.86625299
50STK38L0.85318156
51MAP3K120.80369320
52CDK80.78838886
53PKN10.77876067
54PDK20.75962644
55NTRK30.73384030
56PRKD30.70079466
57PLK10.65070649
58CDC70.64344847
59ROCK10.62761024
60CHEK20.62220526
61LATS10.61968878
62MST40.61693584
63MAP2K40.61614315
64AKT30.59838835
65BUB10.56418337
66CAMK2B0.55658639
67DYRK30.55062431
68GSK3A0.54883060
69TIE10.52808626
70INSRR0.49775398
71CAMK40.49697153
72ATM0.49545520
73EIF2AK20.48167461
74GRK50.46497663
75CAMK2A0.46130011
76ATR0.46043929
77UHMK10.44220861
78ADRBK10.43801297
79CDK30.43678234
80BCR0.41961488
81SGK20.41535044
82CDK50.40074661
83PRKACA0.40001404
84SRPK10.36505020
85OBSCN0.35415714
86ROCK20.35101600
87BRSK20.34692098
88PRKCZ0.34435485
89ERBB40.32771095
90ERBB20.32750810
91CDK90.32285788
92DYRK1A0.31733393
93PIM20.29302294
94PINK10.29157985
95BCKDK0.28544993
96STK30.27102184
97PRKG10.26245131
98TSSK60.26100431
99RPS6KA40.25823592
100PRKCQ0.24297626

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.42839329
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21455193
3Non-homologous end-joining_Homo sapiens_hsa034502.99128243
4Fanconi anemia pathway_Homo sapiens_hsa034602.81024122
5Nicotine addiction_Homo sapiens_hsa050332.78090063
6Butanoate metabolism_Homo sapiens_hsa006502.61828133
7Propanoate metabolism_Homo sapiens_hsa006402.58023474
8Phototransduction_Homo sapiens_hsa047442.43049559
9Steroid biosynthesis_Homo sapiens_hsa001002.31535359
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19926959
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14208556
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99481752
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97832956
14Base excision repair_Homo sapiens_hsa034101.96047548
15Homologous recombination_Homo sapiens_hsa034401.92779736
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86794489
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80747510
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74382412
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60136554
20Nitrogen metabolism_Homo sapiens_hsa009101.51563962
21Oxidative phosphorylation_Homo sapiens_hsa001901.41796378
22Taste transduction_Homo sapiens_hsa047421.37712001
23GABAergic synapse_Homo sapiens_hsa047271.35400721
24Basal transcription factors_Homo sapiens_hsa030221.35098983
25Morphine addiction_Homo sapiens_hsa050321.27674349
26Parkinsons disease_Homo sapiens_hsa050121.24038987
27Fatty acid metabolism_Homo sapiens_hsa012121.22193440
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21297459
29Glutamatergic synapse_Homo sapiens_hsa047241.17228113
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14793972
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14156889
32RNA degradation_Homo sapiens_hsa030181.10782834
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09361144
34beta-Alanine metabolism_Homo sapiens_hsa004101.08916578
35RNA polymerase_Homo sapiens_hsa030201.05822447
36Dopaminergic synapse_Homo sapiens_hsa047281.04835481
37Vitamin B6 metabolism_Homo sapiens_hsa007501.04352722
38Peroxisome_Homo sapiens_hsa041461.04111868
39Selenocompound metabolism_Homo sapiens_hsa004501.03048661
40Huntingtons disease_Homo sapiens_hsa050160.97583135
41Axon guidance_Homo sapiens_hsa043600.97385998
42Circadian entrainment_Homo sapiens_hsa047130.96722436
43Fatty acid elongation_Homo sapiens_hsa000620.96439565
44Olfactory transduction_Homo sapiens_hsa047400.92627149
45Fatty acid degradation_Homo sapiens_hsa000710.91389086
46Amphetamine addiction_Homo sapiens_hsa050310.91108291
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88478161
48Tryptophan metabolism_Homo sapiens_hsa003800.87051596
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86884046
50Glycerolipid metabolism_Homo sapiens_hsa005610.86659502
51Regulation of autophagy_Homo sapiens_hsa041400.86238497
52Fatty acid biosynthesis_Homo sapiens_hsa000610.84292749
53Hedgehog signaling pathway_Homo sapiens_hsa043400.83594979
54Cocaine addiction_Homo sapiens_hsa050300.81146790
55Proteasome_Homo sapiens_hsa030500.79908567
56Oocyte meiosis_Homo sapiens_hsa041140.77580114
57TGF-beta signaling pathway_Homo sapiens_hsa043500.76968123
58Mismatch repair_Homo sapiens_hsa034300.76298041
59Spliceosome_Homo sapiens_hsa030400.76048760
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.75351606
61Retinol metabolism_Homo sapiens_hsa008300.73208768
62p53 signaling pathway_Homo sapiens_hsa041150.72396553
63Insulin secretion_Homo sapiens_hsa049110.71919182
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71473468
65Caffeine metabolism_Homo sapiens_hsa002320.66859565
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66388787
67Alzheimers disease_Homo sapiens_hsa050100.65694028
68Ether lipid metabolism_Homo sapiens_hsa005650.64621067
69Purine metabolism_Homo sapiens_hsa002300.62502760
70Basal cell carcinoma_Homo sapiens_hsa052170.61491709
71RNA transport_Homo sapiens_hsa030130.61479434
72cAMP signaling pathway_Homo sapiens_hsa040240.60384634
73Pyruvate metabolism_Homo sapiens_hsa006200.59370946
74Circadian rhythm_Homo sapiens_hsa047100.59086792
75Linoleic acid metabolism_Homo sapiens_hsa005910.58724885
76PPAR signaling pathway_Homo sapiens_hsa033200.58521086
77ABC transporters_Homo sapiens_hsa020100.57846572
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57295897
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57064316
80Salivary secretion_Homo sapiens_hsa049700.54369879
81Cell cycle_Homo sapiens_hsa041100.53946063
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53388112
83Nucleotide excision repair_Homo sapiens_hsa034200.53183827
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52404846
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52174807
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51021158
87Chemical carcinogenesis_Homo sapiens_hsa052040.50980021
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.50961967
89DNA replication_Homo sapiens_hsa030300.49599417
90Cardiac muscle contraction_Homo sapiens_hsa042600.48500177
91Pyrimidine metabolism_Homo sapiens_hsa002400.47690982
92Gastric acid secretion_Homo sapiens_hsa049710.43810297
93Dorso-ventral axis formation_Homo sapiens_hsa043200.43655123
94Serotonergic synapse_Homo sapiens_hsa047260.41879760
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41460100
96Metabolic pathways_Homo sapiens_hsa011000.41417892
97Collecting duct acid secretion_Homo sapiens_hsa049660.40900922
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37984864
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36445055
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36156663

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