CBX3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal large subunit biogenesis (GO:0042273)9.62325885
2ribosomal small subunit assembly (GO:0000028)7.52894511
3heart valve formation (GO:0003188)7.46822259
4positive regulation of gastrulation (GO:2000543)6.64447790
5cellular response to exogenous dsRNA (GO:0071360)6.16750348
6seminiferous tubule development (GO:0072520)6.10927325
7ether lipid metabolic process (GO:0046485)5.97376524
8ribonucleoprotein complex disassembly (GO:0032988)5.24144381
9gene silencing by RNA (GO:0031047)5.13543115
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.06341626
11regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.92669982
12viral transcription (GO:0019083)4.68743146
13behavioral response to nicotine (GO:0035095)4.53665152
14translational termination (GO:0006415)4.50331605
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.42984707
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.42984707
17phosphatidylinositol acyl-chain remodeling (GO:0036149)4.29903642
18neuronal action potential propagation (GO:0019227)4.26900661
19interleukin-6-mediated signaling pathway (GO:0070102)4.24311321
20phosphorylated carbohydrate dephosphorylation (GO:0046838)4.22760566
21inositol phosphate dephosphorylation (GO:0046855)4.22760566
22organelle disassembly (GO:1903008)4.19035582
23ribosomal small subunit biogenesis (GO:0042274)4.07670435
24cilium or flagellum-dependent cell motility (GO:0001539)4.03853308
25regulation of axon regeneration (GO:0048679)3.94410933
26regulation of neuron projection regeneration (GO:0070570)3.94410933
27inositol phosphate catabolic process (GO:0071545)3.93881968
28sphingosine metabolic process (GO:0006670)3.92215513
29regulation of Golgi to plasma membrane protein transport (GO:0042996)3.91736998
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.90763924
31spermatid development (GO:0007286)3.89941545
32histone H2B ubiquitination (GO:0033523)3.82427455
33DNA methylation involved in gamete generation (GO:0043046)3.81372905
34facial nerve structural organization (GO:0021612)3.80082723
35meiotic cell cycle (GO:0051321)3.76463147
36regulation of cholesterol biosynthetic process (GO:0045540)3.71954974
37glycerol ether metabolic process (GO:0006662)3.69633770
38cellular protein complex disassembly (GO:0043624)3.62505157
39ribonucleoprotein complex biogenesis (GO:0022613)3.52283874
40oogenesis (GO:0048477)3.50822396
41translational elongation (GO:0006414)3.50482380
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47476086
43response to lipoprotein particle (GO:0055094)3.44280956
44intracellular lipid transport (GO:0032365)3.40971611
45regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.40346045
46diol metabolic process (GO:0034311)3.40320028
47forebrain morphogenesis (GO:0048853)3.39921351
48ether metabolic process (GO:0018904)3.38406990
49cellular response to ATP (GO:0071318)3.36504636
50sphingoid metabolic process (GO:0046519)3.36098254
51regulation of male gonad development (GO:2000018)3.35690625
52DNA integration (GO:0015074)3.33763033
53negative regulation of telomere maintenance (GO:0032205)3.33660696
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32626941
55phosphatidylserine acyl-chain remodeling (GO:0036150)3.30001590
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27404940
57macromolecular complex disassembly (GO:0032984)3.26625317
58phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.22442405
59cranial nerve structural organization (GO:0021604)3.21423634
60hair cell differentiation (GO:0035315)3.20348105
61protein targeting to ER (GO:0045047)3.19909124
62cotranslational protein targeting to membrane (GO:0006613)3.15567654
63regulation of synaptic vesicle exocytosis (GO:2000300)3.14802873
64viral life cycle (GO:0019058)3.14058616
65regulation of glycogen (starch) synthase activity (GO:2000465)3.13145122
66protein complex disassembly (GO:0043241)3.11547526
67peptidyl-histidine modification (GO:0018202)3.10020721
68indolalkylamine metabolic process (GO:0006586)3.09791132
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07332288
70autophagic vacuole assembly (GO:0000045)3.05547132
71establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04878576
72mitochondrion transport along microtubule (GO:0047497)3.04878576
73negative regulation of glycoprotein biosynthetic process (GO:0010561)3.04231045
74cornea development in camera-type eye (GO:0061303)3.02367831
75regulation of synaptic vesicle transport (GO:1902803)2.98199101
76proline transport (GO:0015824)2.94409364
77icosanoid secretion (GO:0032309)2.91276999
78arachidonic acid secretion (GO:0050482)2.91276999
79positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.89762692
80protein localization to endoplasmic reticulum (GO:0070972)2.89613681
81postsynaptic membrane organization (GO:0001941)2.88805515
82neural tube formation (GO:0001841)2.84374577
83phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.83855346
84positive regulation of defense response to virus by host (GO:0002230)2.83590971
85negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.82391880
86interkinetic nuclear migration (GO:0022027)2.80354820
87establishment of mitochondrion localization (GO:0051654)2.80002282
88phosphatidylcholine acyl-chain remodeling (GO:0036151)2.75896149
89negative regulation of cell cycle G2/M phase transition (GO:1902750)2.74698620
90regulation of odontogenesis (GO:0042481)2.72509145
91response to manganese ion (GO:0010042)2.72478770
92protein localization to microtubule (GO:0035372)2.71695405
93positive regulation of guanylate cyclase activity (GO:0031284)2.70315683
94regulation of glutamate receptor signaling pathway (GO:1900449)2.66786263
95positive regulation of embryonic development (GO:0040019)2.66768129
96cellular response to dsRNA (GO:0071359)2.66523295
97negative regulation of translational initiation (GO:0045947)2.64752083
98mitochondrial fission (GO:0000266)2.64047887
99sympathetic nervous system development (GO:0048485)2.62936291
100piRNA metabolic process (GO:0034587)12.8528495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.43405281
2VDR_22108803_ChIP-Seq_LS180_Human6.59270137
3GATA1_22025678_ChIP-Seq_K562_Human3.81457186
4IGF1R_20145208_ChIP-Seq_DFB_Human3.69276128
5EZH2_22144423_ChIP-Seq_EOC_Human3.67364580
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.51414610
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.33563637
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.21709514
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80094761
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69317077
11FUS_26573619_Chip-Seq_HEK293_Human2.60912485
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42269577
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37526095
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22418785
15AR_21572438_ChIP-Seq_LNCaP_Human2.03201003
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00701620
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85242380
18GBX2_23144817_ChIP-Seq_PC3_Human1.77253295
19TAF15_26573619_Chip-Seq_HEK293_Human1.76940340
20ER_23166858_ChIP-Seq_MCF-7_Human1.75441800
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74841902
22EWS_26573619_Chip-Seq_HEK293_Human1.62678571
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.58666842
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50563189
25P300_19829295_ChIP-Seq_ESCs_Human1.47625289
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46879681
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45006131
28REST_21632747_ChIP-Seq_MESCs_Mouse1.42844273
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.39971421
30LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36626158
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28255044
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28255044
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.28023864
34RNF2_27304074_Chip-Seq_NSC_Mouse1.27787617
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26361120
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26064134
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.21890324
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21520671
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21176447
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20962355
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19798100
42OCT4_20526341_ChIP-Seq_ESCs_Human1.18652502
43NANOG_20526341_ChIP-Seq_ESCs_Human1.17232416
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16852052
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.15645401
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.14887277
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13739316
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13180907
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13074065
50CBP_20019798_ChIP-Seq_JUKART_Human1.13074065
51TCF4_23295773_ChIP-Seq_U87_Human1.12611558
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.11809734
53STAT3_23295773_ChIP-Seq_U87_Human1.09619231
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.06920666
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06869053
56CIITA_25753668_ChIP-Seq_RAJI_Human1.05106021
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03263402
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02226202
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01465750
60TP53_18474530_ChIP-ChIP_U2OS_Human0.99769374
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97938554
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96674162
63SMAD4_21799915_ChIP-Seq_A2780_Human0.95305701
64ZNF274_21170338_ChIP-Seq_K562_Hela0.95201629
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94730732
66WDR5_24793694_ChIP-Seq_LNCAP_Human0.94599386
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94495808
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94495808
69RNF2_27304074_Chip-Seq_ESCs_Mouse0.94038887
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93104427
71JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92860700
72AR_25329375_ChIP-Seq_VCAP_Human0.92419672
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92035775
74SMAD3_21741376_ChIP-Seq_ESCs_Human0.89437599
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88718247
76TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88167321
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87700704
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87672750
79TAL1_26923725_Chip-Seq_HPCs_Mouse0.87384938
80SOX2_21211035_ChIP-Seq_LN229_Gbm0.86154217
81RAC3_21632823_ChIP-Seq_H3396_Human0.86151915
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85427909
83TP53_16413492_ChIP-PET_HCT116_Human0.84669056
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84656575
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84182464
86EGR1_19032775_ChIP-ChIP_M12_Human0.83454218
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83009911
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.82662049
89TCF4_22108803_ChIP-Seq_LS180_Human0.82079998
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81547254
91SCL_19346495_ChIP-Seq_HPC-7_Human0.81383455
92AR_19668381_ChIP-Seq_PC3_Human0.80454114
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.79583710
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.77361879
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76765259
96RXR_22108803_ChIP-Seq_LS180_Human0.76234394
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74918569
98SOX2_19829295_ChIP-Seq_ESCs_Human0.73972132
99NANOG_19829295_ChIP-Seq_ESCs_Human0.73972132
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73007249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.01033360
2MP0005171_absent_coat_pigmentation4.48861525
3MP0001986_abnormal_taste_sensitivity4.41053169
4MP0002653_abnormal_ependyma_morphology3.92116668
5MP0006292_abnormal_olfactory_placode3.91309998
6MP0003136_yellow_coat_color3.82828224
7MP0000013_abnormal_adipose_tissue3.18577604
8MP0005503_abnormal_tendon_morphology3.18312912
9MP0001968_abnormal_touch/_nociception2.59326471
10MP0004147_increased_porphyrin_level2.41052651
11MP0003880_abnormal_central_pattern2.30997468
12MP0003690_abnormal_glial_cell2.12395167
13MP0005167_abnormal_blood-brain_barrier2.04834568
14MP0002735_abnormal_chemical_nociception2.04376595
15MP0002938_white_spotting1.86397582
16MP0010386_abnormal_urinary_bladder1.84957079
17MP0008789_abnormal_olfactory_epithelium1.74462606
18MP0003172_abnormal_lysosome_physiology1.65979044
19MP0000681_abnormal_thyroid_gland1.64898946
20MP0001486_abnormal_startle_reflex1.63446359
21MP0000372_irregular_coat_pigmentation1.59543464
22MP0000749_muscle_degeneration1.57146180
23MP0009384_cardiac_valve_regurgitation1.54550959
24MP0009745_abnormal_behavioral_response1.53340230
25MP0009697_abnormal_copulation1.53187530
26MP0002272_abnormal_nervous_system1.48404389
27MP0003045_fibrosis1.46916492
28MP0005394_taste/olfaction_phenotype1.45418304
29MP0005499_abnormal_olfactory_system1.45418304
30MP0002572_abnormal_emotion/affect_behav1.39929623
31MP0003786_premature_aging1.37691884
32MP0002064_seizures1.37628531
33MP0002638_abnormal_pupillary_reflex1.31897302
34MP0005058_abnormal_lysosome_morphology1.28790299
35MP0004043_abnormal_pH_regulation1.28730772
36MP0005075_abnormal_melanosome_morpholog1.26434163
37MP0005257_abnormal_intraocular_pressure1.22062473
38MP0004484_altered_response_of1.19174366
39MP0002067_abnormal_sensory_capabilities1.18641461
40MP0002733_abnormal_thermal_nociception1.18034303
41MP0002734_abnormal_mechanical_nocicepti1.17654011
42MP0003137_abnormal_impulse_conducting1.16513252
43MP0005253_abnormal_eye_physiology1.15006337
44MP0003635_abnormal_synaptic_transmissio1.14689712
45MP0003633_abnormal_nervous_system1.14237418
46MP0005551_abnormal_eye_electrophysiolog1.07397183
47MP0002108_abnormal_muscle_morphology1.07157427
48MP0003724_increased_susceptibility_to1.06636965
49MP0005423_abnormal_somatic_nervous1.05214887
50MP0005174_abnormal_tail_pigmentation1.05193619
51MP0003787_abnormal_imprinting1.05042462
52MP0001970_abnormal_pain_threshold1.04524097
53MP0003879_abnormal_hair_cell1.03814405
54MP0000358_abnormal_cell_content/1.01373571
55MP0002138_abnormal_hepatobiliary_system1.00504256
56MP0002234_abnormal_pharynx_morphology0.99886771
57MP0004145_abnormal_muscle_electrophysio0.99492050
58MP0004859_abnormal_synaptic_plasticity0.99045513
59MP0003698_abnormal_male_reproductive0.98201372
60MP0002877_abnormal_melanocyte_morpholog0.98199987
61MP0005646_abnormal_pituitary_gland0.97698827
62MP0005367_renal/urinary_system_phenotyp0.96281339
63MP0000516_abnormal_urinary_system0.96281339
64MP0000778_abnormal_nervous_system0.95785034
65MP0006072_abnormal_retinal_apoptosis0.94771069
66MP0006276_abnormal_autonomic_nervous0.93968610
67MP0003631_nervous_system_phenotype0.93143711
68MP0003122_maternal_imprinting0.92362944
69MP0009379_abnormal_foot_pigmentation0.92196020
70MP0003191_abnormal_cellular_cholesterol0.91597202
71MP0002928_abnormal_bile_duct0.91537813
72MP0002557_abnormal_social/conspecific_i0.91337586
73MP0008872_abnormal_physiological_respon0.91265243
74MP0000026_abnormal_inner_ear0.90722485
75MP0004924_abnormal_behavior0.90326655
76MP0005386_behavior/neurological_phenoty0.90326655
77MP0001502_abnormal_circadian_rhythm0.89845351
78MP0001324_abnormal_eye_pigmentation0.89058227
79MP0004742_abnormal_vestibular_system0.88679833
80MP0004142_abnormal_muscle_tone0.88658943
81MP0000569_abnormal_digit_pigmentation0.87985693
82MP0001293_anophthalmia0.87909538
83MP0008569_lethality_at_weaning0.86119982
84MP0009046_muscle_twitch0.85952067
85MP0002210_abnormal_sex_determination0.85308037
86MP0002229_neurodegeneration0.83967612
87MP0000427_abnormal_hair_cycle0.83684147
88MP0002160_abnormal_reproductive_system0.82333180
89MP0002063_abnormal_learning/memory/cond0.82229379
90MP0001905_abnormal_dopamine_level0.82152277
91MP0001485_abnormal_pinna_reflex0.79977876
92MP0005084_abnormal_gallbladder_morpholo0.79335004
93MP0002269_muscular_atrophy0.78901554
94MP0004084_abnormal_cardiac_muscle0.78051731
95MP0004270_analgesia0.77940212
96MP0001963_abnormal_hearing_physiology0.76543059
97MP0003075_altered_response_to0.73670766
98MP0000653_abnormal_sex_gland0.73168623
99MP0005360_urolithiasis0.72759998
100MP0001145_abnormal_male_reproductive0.72304972

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)7.97141114
2Chronic hepatic failure (HP:0100626)6.53598828
3Retinal dysplasia (HP:0007973)4.79569771
4Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.49769016
5Focal motor seizures (HP:0011153)4.29536733
6Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.16024409
7Protruding tongue (HP:0010808)4.09269354
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.85691970
9Epileptic encephalopathy (HP:0200134)3.79504564
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.78892775
11Abnormality of alanine metabolism (HP:0010916)3.78892775
12Hyperalaninemia (HP:0003348)3.78892775
13Colon cancer (HP:0003003)3.76267984
14Ulnar claw (HP:0001178)3.60755382
15Microvesicular hepatic steatosis (HP:0001414)3.31696508
16Termporal pattern (HP:0011008)3.29159380
17Insidious onset (HP:0003587)3.29159380
18Atonic seizures (HP:0010819)3.27751124
19Neurodegeneration (HP:0002180)2.91533133
20Macrocytic anemia (HP:0001972)2.88197270
21Multiple enchondromatosis (HP:0005701)2.86768839
22Abnormality of midbrain morphology (HP:0002418)2.85569693
23Molar tooth sign on MRI (HP:0002419)2.85569693
24Progressive inability to walk (HP:0002505)2.85561678
25Dialeptic seizures (HP:0011146)2.79747351
26Elevated erythrocyte sedimentation rate (HP:0003565)2.76136003
27Amelogenesis imperfecta (HP:0000705)2.75890914
283-Methylglutaconic aciduria (HP:0003535)2.75350091
29Cerebellar dysplasia (HP:0007033)2.73712578
30Parakeratosis (HP:0001036)2.63745083
31Abnormality of binocular vision (HP:0011514)2.60064591
32Diplopia (HP:0000651)2.60064591
33Brushfield spots (HP:0001088)2.58918940
34Pallor (HP:0000980)2.58749827
35Progressive external ophthalmoplegia (HP:0000590)2.54761373
36Dyschromatopsia (HP:0007641)2.52567664
37Long clavicles (HP:0000890)2.51729146
38Abnormal number of erythroid precursors (HP:0012131)2.50253623
39Erythroderma (HP:0001019)2.41510700
40Cervical subluxation (HP:0003308)2.37736286
41Tachypnea (HP:0002789)2.32970246
42Radial bowing (HP:0002986)2.32634894
43Aplasia/Hypoplasia of the brainstem (HP:0007362)2.31962660
44Hypoplasia of the brainstem (HP:0002365)2.31962660
45Hypoplastic iliac wings (HP:0002866)2.31662055
46Steppage gait (HP:0003376)2.29909078
47Type II lissencephaly (HP:0007260)2.28714871
48Metaphyseal dysplasia (HP:0100255)2.26471150
49Focal seizures (HP:0007359)2.26138220
50Increased CSF protein (HP:0002922)2.23917837
51CNS hypomyelination (HP:0003429)2.19420404
52Abnormality of cells of the erythroid lineage (HP:0012130)2.18017717
53Absence seizures (HP:0002121)2.13955654
54Inability to walk (HP:0002540)2.13587311
55Abnormality of the vocal cords (HP:0008777)2.09816529
56Broad-based gait (HP:0002136)2.09573232
57Triphalangeal thumb (HP:0001199)2.08607705
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07935280
59Autoimmune thrombocytopenia (HP:0001973)2.07468389
60Self-mutilation (HP:0000742)2.06535932
61Abnormality of the sella turcica (HP:0002679)2.06325888
62Congenital hepatic fibrosis (HP:0002612)2.05080570
63Depressed nasal ridge (HP:0000457)2.03344299
64Meningocele (HP:0002435)1.98255565
65Drooling (HP:0002307)1.98110640
66Abnormality of the femoral head (HP:0003368)1.96076182
67Poikiloderma (HP:0001029)1.95937222
68Interstitial pulmonary disease (HP:0006530)1.95106625
69Joint stiffness (HP:0001387)1.94169455
70Truncal obesity (HP:0001956)1.93488756
71Sensorimotor neuropathy (HP:0007141)1.90327648
72Optic nerve coloboma (HP:0000588)1.89940453
73Difficulty walking (HP:0002355)1.86824562
74Choroideremia (HP:0001139)1.85854770
75Pancreatic cysts (HP:0001737)1.85579506
76Increased neuronal autofluorescent lipopigment (HP:0002074)1.84412593
77Myokymia (HP:0002411)1.83680793
78Myotonia (HP:0002486)1.83343898
79J-shaped sella turcica (HP:0002680)1.83162462
80Congenital ichthyosiform erythroderma (HP:0007431)1.82979344
81Thyroid-stimulating hormone excess (HP:0002925)1.82800060
82Decreased subcutaneous fat (HP:0001002)1.81662774
83Abnormality of the columella (HP:0009929)1.80645764
84Abnormality of saccadic eye movements (HP:0000570)1.79670913
85Excessive salivation (HP:0003781)1.79386286
86Bundle branch block (HP:0011710)1.76298017
87Scrotal hypoplasia (HP:0000046)1.74324026
88Abnormality of lateral ventricle (HP:0030047)1.74153343
89Long nose (HP:0003189)1.70711608
90Thick lower lip vermilion (HP:0000179)1.69450241
91Hypoplasia of the odontoid process (HP:0003311)1.69371313
92Thickened nuchal skin fold (HP:0000474)1.69281402
93Hyperventilation (HP:0002883)1.68941962
94Retinal atrophy (HP:0001105)1.68607204
95Abnormality of the odontoid process (HP:0003310)1.67266027
96Premature ovarian failure (HP:0008209)1.67223477
97Failure to thrive in infancy (HP:0001531)1.66654636
98Absent phalangeal crease (HP:0006109)1.65775615
99Hyperglycinuria (HP:0003108)1.65652806
100Abnormality of the wing of the ilium (HP:0011867)1.64395987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM286.06213151
2DAPK25.46078033
3LATS13.74961269
4CASK3.34668840
5RPS6KB23.25068122
6DAPK13.21842181
7STK38L2.67258394
8FRK2.39842067
9PINK12.35510410
10LATS22.35314825
11MKNK12.22398270
12ACVR1B2.10942341
13CDC72.10149953
14RPS6KC12.04178004
15RPS6KL12.04178004
16RPS6KA61.88059943
17PAK31.81163421
18MAPK131.80910612
19MAPKAPK51.80559035
20TAF11.51856530
21PAK61.47122330
22DAPK31.42560475
23MAPKAPK31.35271138
24DYRK1B1.33722259
25KSR21.31656404
26NME21.31296594
27STK381.15918652
28RPS6KA21.09628226
29STK241.09143153
30PIK3CG1.04601366
31MAP3K41.03609591
32TNK21.02887217
33RAF10.96532028
34TIE10.89925590
35NTRK20.88334264
36CSNK1G20.83533335
37MELK0.83526240
38PAK20.81767412
39NTRK10.81718192
40PHKG10.81316785
41PHKG20.81316785
42CCNB10.80492587
43RPS6KB10.79126389
44STK30.75121674
45MAP2K10.65776452
46TYRO30.65501896
47OBSCN0.65280153
48CAMKK20.64604441
49SGK4940.64367586
50SGK2230.64367586
51MATK0.63325917
52SGK20.63169288
53NUAK10.62788973
54PRKG20.62714726
55PRKACB0.62302062
56MINK10.60297666
57UHMK10.57120111
58MAP2K20.56917238
59PRKAA20.56662799
60NEK20.56356423
61CAMKK10.54861723
62BRSK20.53358503
63MAP4K10.52469930
64RPS6KA10.50495390
65MKNK20.50468168
66DYRK1A0.49084653
67PLK40.46471534
68CSNK1A1L0.46082326
69CHEK20.45858154
70FGFR20.45550769
71MARK10.45413255
72STK110.45388288
73KIT0.43327694
74ADRBK10.42644224
75TBK10.40749019
76CSNK1G30.40731400
77PRKCH0.40228520
78KSR10.39983935
79CDK80.39536577
80CAMK2A0.38924027
81MAPK70.38566096
82ABL10.38403534
83CSNK1A10.37451726
84RPS6KA30.36886978
85GRK70.36367734
86SYK0.34937340
87PDPK10.34858567
88PIM10.34501467
89RIPK40.32200886
90GRK50.29595332
91BTK0.29270106
92EPHA30.28937164
93ERBB30.28901348
94TEC0.28117060
95ITK0.27380650
96PRKD30.27014421
97IKBKB0.26931470
98MAP4K20.26408302
99ZAK0.23962407
100PRKD10.23518261

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043205.53404248
2Ribosome_Homo sapiens_hsa030103.78010869
3Phototransduction_Homo sapiens_hsa047443.26556503
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.76621709
5Regulation of autophagy_Homo sapiens_hsa041402.76189826
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67109361
7Linoleic acid metabolism_Homo sapiens_hsa005912.58720280
8Nicotine addiction_Homo sapiens_hsa050332.47316308
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.37306645
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10708559
11Long-term depression_Homo sapiens_hsa047302.04671629
12Ether lipid metabolism_Homo sapiens_hsa005651.99831636
13Peroxisome_Homo sapiens_hsa041461.84174275
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84164807
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79621259
16Glutamatergic synapse_Homo sapiens_hsa047241.73978068
17Ovarian steroidogenesis_Homo sapiens_hsa049131.69960270
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68552911
19GABAergic synapse_Homo sapiens_hsa047271.63927827
20Morphine addiction_Homo sapiens_hsa050321.63033317
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43554345
22Basal transcription factors_Homo sapiens_hsa030221.40011642
23Sphingolipid metabolism_Homo sapiens_hsa006001.39844796
24VEGF signaling pathway_Homo sapiens_hsa043701.35954918
25Serotonergic synapse_Homo sapiens_hsa047261.34236122
26Butanoate metabolism_Homo sapiens_hsa006501.29320323
27Taste transduction_Homo sapiens_hsa047421.21377226
28Olfactory transduction_Homo sapiens_hsa047401.21099129
29Circadian entrainment_Homo sapiens_hsa047131.18741472
30Oxytocin signaling pathway_Homo sapiens_hsa049211.17866065
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15244067
32Salivary secretion_Homo sapiens_hsa049701.08871233
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08451410
34Cholinergic synapse_Homo sapiens_hsa047251.07915705
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07631250
36Arachidonic acid metabolism_Homo sapiens_hsa005901.01481411
37Calcium signaling pathway_Homo sapiens_hsa040200.99070522
38Synaptic vesicle cycle_Homo sapiens_hsa047210.98573805
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97671347
40Long-term potentiation_Homo sapiens_hsa047200.94998719
41Dopaminergic synapse_Homo sapiens_hsa047280.91946512
42Tryptophan metabolism_Homo sapiens_hsa003800.91184038
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87257665
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87177360
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84688400
46Insulin secretion_Homo sapiens_hsa049110.84493215
47GnRH signaling pathway_Homo sapiens_hsa049120.84401734
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.83743017
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.79733726
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.78340755
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76780072
52Cardiac muscle contraction_Homo sapiens_hsa042600.76744083
53p53 signaling pathway_Homo sapiens_hsa041150.76730566
54ABC transporters_Homo sapiens_hsa020100.74768755
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74363378
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69462837
57Gap junction_Homo sapiens_hsa045400.68779179
58beta-Alanine metabolism_Homo sapiens_hsa004100.68455114
59Gastric acid secretion_Homo sapiens_hsa049710.67628667
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.67506586
61Amphetamine addiction_Homo sapiens_hsa050310.67372840
62Bladder cancer_Homo sapiens_hsa052190.64393541
63One carbon pool by folate_Homo sapiens_hsa006700.62731162
64Bile secretion_Homo sapiens_hsa049760.62502297
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61044223
66Oocyte meiosis_Homo sapiens_hsa041140.59608255
67Platelet activation_Homo sapiens_hsa046110.59176524
68Dilated cardiomyopathy_Homo sapiens_hsa054140.58285041
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53618757
70Melanogenesis_Homo sapiens_hsa049160.53143731
71Ras signaling pathway_Homo sapiens_hsa040140.50646728
72Pancreatic secretion_Homo sapiens_hsa049720.50604599
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48695201
74Non-homologous end-joining_Homo sapiens_hsa034500.45970257
75Alcoholism_Homo sapiens_hsa050340.41165103
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.40334106
77Propanoate metabolism_Homo sapiens_hsa006400.39062826
78Asthma_Homo sapiens_hsa053100.38294231
79mTOR signaling pathway_Homo sapiens_hsa041500.37644851
80cAMP signaling pathway_Homo sapiens_hsa040240.36549418
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36248470
82MAPK signaling pathway_Homo sapiens_hsa040100.36150593
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.35713624
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35021747
85Endometrial cancer_Homo sapiens_hsa052130.34146164
86ErbB signaling pathway_Homo sapiens_hsa040120.29600205
87Galactose metabolism_Homo sapiens_hsa000520.29557540
88Glioma_Homo sapiens_hsa052140.28906224
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27133760
90RNA degradation_Homo sapiens_hsa030180.27045222
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26813419
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26297871
93Thyroid hormone synthesis_Homo sapiens_hsa049180.26100679
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24477951
95Fatty acid degradation_Homo sapiens_hsa000710.23935586
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22768346
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22337776
98Melanoma_Homo sapiens_hsa052180.22050873
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21099029
100Circadian rhythm_Homo sapiens_hsa047100.20424027

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