ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lysine catabolic process (GO:0006554)	6.30241727
2	lysine metabolic process (GO:0006553)	6.30241727
3	tryptophan metabolic process (GO:0006568)	6.26645030
4	kynurenine metabolic process (GO:0070189)	6.02078706
5	indolalkylamine metabolic process (GO:0006586)	5.84729534
6	tryptophan catabolic process (GO:0006569)	5.58866793
7	indole-containing compound catabolic process (GO:0042436)	5.58866793
8	indolalkylamine catabolic process (GO:0046218)	5.58866793
9	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.31482095
10	growth hormone secretion (GO:0030252)	4.94246324
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.81488699
12	adult feeding behavior (GO:0008343)	4.76389625
13	indole-containing compound metabolic process (GO:0042430)	4.30162285
14	negative regulation of interleukin-1 beta production (GO:0032691)	4.29591878
15	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.23105551
16	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	4.15146581
17	activated T cell proliferation (GO:0050798)	4.08031184
18	aspartate family amino acid catabolic process (GO:0009068)	4.04763297
19	positive regulation of action potential (GO:0045760)	3.93464141
20	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.81717592
21	urinary tract smooth muscle contraction (GO:0014848)	3.79376026
22	tachykinin receptor signaling pathway (GO:0007217)	3.73716541
23	epithelial cilium movement (GO:0003351)	3.72675490
24	adaptation of signaling pathway (GO:0023058)	3.71820951
25	hindbrain development (GO:0030902)	3.71610792
26	lactate metabolic process (GO:0006089)	3.69860559
27	cilium movement (GO:0003341)	3.66157903
28	aggressive behavior (GO:0002118)	3.57882068
29	regulation of action potential (GO:0098900)	3.52833460
30	aldehyde catabolic process (GO:0046185)	3.52089930
31	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.49780551
32	kidney morphogenesis (GO:0060993)	3.49513948
33	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.48310741
34	negative regulation of interleukin-1 production (GO:0032692)	3.47497039
35	cellular biogenic amine catabolic process (GO:0042402)	3.37776819
36	amine catabolic process (GO:0009310)	3.37776819
37	response to food (GO:0032094)	3.36325029
38	2-oxoglutarate metabolic process (GO:0006103)	3.36038483
39	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.33653312
40	L-fucose catabolic process (GO:0042355)	3.29433430
41	fucose catabolic process (GO:0019317)	3.29433430
42	L-fucose metabolic process (GO:0042354)	3.29433430
43	somite rostral/caudal axis specification (GO:0032525)	3.23355927
44	positive regulation of digestive system process (GO:0060456)	3.13500902
45	regulation of meiosis I (GO:0060631)	3.12551690
46	cilium morphogenesis (GO:0060271)	3.11123281
47	behavioral response to nicotine (GO:0035095)	3.09322305
48	regulation of male gonad development (GO:2000018)	3.07125715
49	intraciliary transport (GO:0042073)	2.98762024
50	cellular response to ATP (GO:0071318)	2.97180366
51	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.96420279
52	presynaptic membrane assembly (GO:0097105)	2.93017636
53	drinking behavior (GO:0042756)	2.89774981
54	positive regulation of vascular permeability (GO:0043117)	2.87806080
55	aromatic amino acid family catabolic process (GO:0009074)	2.86973456
56	ubiquinone biosynthetic process (GO:0006744)	2.85406043
57	histone mRNA catabolic process (GO:0071044)	2.84245389
58	cornea development in camera-type eye (GO:0061303)	2.83653613
59	regulation of penile erection (GO:0060405)	2.83444119
60	regulation of digestive system process (GO:0044058)	2.81045600
61	ubiquinone metabolic process (GO:0006743)	2.79878820
62	aromatic amino acid family metabolic process (GO:0009072)	2.77233027
63	auditory receptor cell stereocilium organization (GO:0060088)	2.74904851
64	adenosine metabolic process (GO:0046085)	2.73637161
65	behavioral response to ethanol (GO:0048149)	2.72953169
66	benzene-containing compound metabolic process (GO:0042537)	2.71423317
67	negative regulation of mast cell activation (GO:0033004)	2.71354331
68	spinal cord development (GO:0021510)	2.69765769
69	pseudouridine synthesis (GO:0001522)	2.68491766
70	rRNA methylation (GO:0031167)	2.66696419
71	basic amino acid transport (GO:0015802)	2.65819591
72	cilium organization (GO:0044782)	2.65020371
73	meiotic cell cycle (GO:0051321)	2.64618725
74	regulation of uterine smooth muscle contraction (GO:0070472)	2.64175440
75	inner ear receptor stereocilium organization (GO:0060122)	2.61856141
76	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.60120745
77	detection of light stimulus involved in sensory perception (GO:0050962)	2.56103123
78	detection of light stimulus involved in visual perception (GO:0050908)	2.56103123
79	platelet dense granule organization (GO:0060155)	2.55475144
80	negative regulation of T cell differentiation in thymus (GO:0033085)	2.54906749
81	regulation of response to food (GO:0032095)	2.54846505
82	cilium assembly (GO:0042384)	2.54407479
83	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53842011
84	negative regulation of meiosis (GO:0045835)	2.50584034
85	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.48917709
86	chemosensory behavior (GO:0007635)	2.48883062
87	piRNA metabolic process (GO:0034587)	2.48553768
88	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.48356365
89	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.47973098
90	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.47462946
91	interferon-gamma secretion (GO:0072643)	2.44773630
92	quinone biosynthetic process (GO:1901663)	2.43921668
93	magnesium ion transport (GO:0015693)	2.43841303
94	reciprocal DNA recombination (GO:0035825)	2.42999346
95	reciprocal meiotic recombination (GO:0007131)	2.42999346
96	protein polyglutamylation (GO:0018095)	2.42635232
97	nucleotide transmembrane transport (GO:1901679)	2.42335561
98	sulfation (GO:0051923)	2.42265422
99	negative regulation by host of viral transcription (GO:0043922)	2.41229638
100	photoreceptor cell maintenance (GO:0045494)	2.41193904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	5.10678366
2	VDR_22108803_ChIP-Seq_LS180_Human	4.41655876
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.94091765
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78801646
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.84140406
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69489239
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.67630205
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.52368471
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51343345
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35642470
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30311650
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.29721196
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.26957737
14	EWS_26573619_Chip-Seq_HEK293_Human	2.23536606
15	FUS_26573619_Chip-Seq_HEK293_Human	2.23185541
16	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.16060097
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13719479
18	P300_19829295_ChIP-Seq_ESCs_Human	2.12322650
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11727938
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.98530833
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97937821
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91567921
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90951223
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83490517
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83438205
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83365350
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.83282516
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.81835298
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77094802
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76789245
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66803895
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65811886
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.65811886
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.65600232
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64678333
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.56605057
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.54127506
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51649490
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47513450
40	STAT3_23295773_ChIP-Seq_U87_Human	1.46260575
41	AR_25329375_ChIP-Seq_VCAP_Human	1.43352501
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43328051
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42889099
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39938315
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.38270962
46	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.36914509
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36630783
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35753054
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35616667
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34828482
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34828482
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33716576
53	RXR_22108803_ChIP-Seq_LS180_Human	1.31626784
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.26883269
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25501392
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23233928
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22080811
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21613616
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18929699
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18929699
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18233974
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16402673
63	TCF4_23295773_ChIP-Seq_U87_Human	1.15931394
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.15652260
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14839058
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14529620
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13674890
68	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.13191061
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12643041
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12327960
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12209938
72	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11185418
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10534786
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10105032
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08532766
76	NCOR_22424771_ChIP-Seq_293T_Human	1.07536105
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05224189
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04883040
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03491630
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03413294
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02074107
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01701548
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01141783
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00159170
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00116637
86	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.99738376
87	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99069409
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98131455
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98131455
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.96113463
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95560842
92	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.95509193
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94606155
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94543904
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94165491
96	TP53_16413492_ChIP-PET_HCT116_Human	0.93738767
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93597681
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.93124550
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93017312
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92841603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.84123845
2	MP0010234_abnormal_vibrissa_follicle	3.71181013
3	MP0008872_abnormal_physiological_respon	3.68087625
4	MP0001529_abnormal_vocalization	3.19133512
5	MP0002653_abnormal_ependyma_morphology	3.08653361
6	MP0005084_abnormal_gallbladder_morpholo	3.03451805
7	MP0001968_abnormal_touch/_nociception	2.51414148
8	MP0002736_abnormal_nociception_after	2.48185348
9	MP0003880_abnormal_central_pattern	2.45279065
10	MP0002234_abnormal_pharynx_morphology	2.22981764
11	MP0010678_abnormal_skin_adnexa	2.14045221
12	MP0005220_abnormal_exocrine_pancreas	2.13140243
13	MP0003252_abnormal_bile_duct	2.07377721
14	MP0009046_muscle_twitch	2.07318007
15	MP0002735_abnormal_chemical_nociception	2.01133468
16	MP0002928_abnormal_bile_duct	2.00912750
17	MP0002638_abnormal_pupillary_reflex	1.87169930
18	MP0008877_abnormal_DNA_methylation	1.83402415
19	MP0002734_abnormal_mechanical_nocicepti	1.81269232
20	MP0006276_abnormal_autonomic_nervous	1.80587587
21	MP0008995_early_reproductive_senescence	1.78452821
22	MP0009697_abnormal_copulation	1.73896217
23	MP0001986_abnormal_taste_sensitivity	1.69372489
24	MP0003119_abnormal_digestive_system	1.66155434
25	MP0006072_abnormal_retinal_apoptosis	1.65866104
26	MP0000383_abnormal_hair_follicle	1.64497210
27	MP0003890_abnormal_embryonic-extraembry	1.63564550
28	MP0009745_abnormal_behavioral_response	1.62837484
29	MP0002876_abnormal_thyroid_physiology	1.62698578
30	MP0000427_abnormal_hair_cycle	1.61702673
31	MP0005551_abnormal_eye_electrophysiolog	1.61059977
32	MP0004215_abnormal_myocardial_fiber	1.60584163
33	MP0004270_analgesia	1.59987175
34	MP0000631_abnormal_neuroendocrine_gland	1.52988424
35	MP0003937_abnormal_limbs/digits/tail_de	1.38771381
36	MP0002272_abnormal_nervous_system	1.38691613
37	MP0006292_abnormal_olfactory_placode	1.37950899
38	MP0006054_spinal_hemorrhage	1.36934240
39	MP0002938_white_spotting	1.35402119
40	MP0002572_abnormal_emotion/affect_behav	1.34470945
41	MP0008875_abnormal_xenobiotic_pharmacok	1.34344327
42	MP0002822_catalepsy	1.33822136
43	MP0002067_abnormal_sensory_capabilities	1.30453789
44	MP0000538_abnormal_urinary_bladder	1.29816021
45	MP0002102_abnormal_ear_morphology	1.28064693
46	MP0001984_abnormal_olfaction	1.27732243
47	MP0005386_behavior/neurological_phenoty	1.27201566
48	MP0004924_abnormal_behavior	1.27201566
49	MP0001502_abnormal_circadian_rhythm	1.26513535
50	MP0000778_abnormal_nervous_system	1.23201281
51	MP0003868_abnormal_feces_composition	1.21046377
52	MP0002063_abnormal_learning/memory/cond	1.20289920
53	MP0001270_distended_abdomen	1.18800189
54	MP0001501_abnormal_sleep_pattern	1.18762119
55	MP0004043_abnormal_pH_regulation	1.15766050
56	MP0003787_abnormal_imprinting	1.15177496
57	MP0006036_abnormal_mitochondrial_physio	1.13927650
58	MP0004147_increased_porphyrin_level	1.10093816
59	MP0001486_abnormal_startle_reflex	1.10038289
60	MP0001177_atelectasis	1.08489977
61	MP0002557_abnormal_social/conspecific_i	1.05728453
62	MP0000467_abnormal_esophagus_morphology	1.05351956
63	MP0002282_abnormal_trachea_morphology	1.02724641
64	MP0008058_abnormal_DNA_repair	1.02368521
65	MP0005085_abnormal_gallbladder_physiolo	1.02159378
66	MP0003635_abnormal_synaptic_transmissio	1.01782396
67	MP0000955_abnormal_spinal_cord	1.01348601
68	MP0005367_renal/urinary_system_phenotyp	0.99207861
69	MP0000516_abnormal_urinary_system	0.99207861
70	MP0002751_abnormal_autonomic_nervous	0.97820592
71	MP0003693_abnormal_embryo_hatching	0.97646589
72	MP0005647_abnormal_sex_gland	0.96952943
73	MP0010386_abnormal_urinary_bladder	0.95624766
74	MP0002277_abnormal_respiratory_mucosa	0.93751539
75	MP0005253_abnormal_eye_physiology	0.88569865
76	MP0002752_abnormal_somatic_nervous	0.84837746
77	MP0002160_abnormal_reproductive_system	0.84221362
78	MP0009780_abnormal_chondrocyte_physiolo	0.83676430
79	MP0002064_seizures	0.83401433
80	MP0005623_abnormal_meninges_morphology	0.80653948
81	MP0005499_abnormal_olfactory_system	0.79183059
82	MP0005394_taste/olfaction_phenotype	0.79183059
83	MP0003936_abnormal_reproductive_system	0.77437125
84	MP0004142_abnormal_muscle_tone	0.76550095
85	MP0001919_abnormal_reproductive_system	0.76120449
86	MP0003283_abnormal_digestive_organ	0.74454853
87	MP0006035_abnormal_mitochondrial_morpho	0.74392000
88	MP0010329_abnormal_lipoprotein_level	0.74321402
89	MP0005174_abnormal_tail_pigmentation	0.74260431
90	MP0003633_abnormal_nervous_system	0.71045243
91	MP0002233_abnormal_nose_morphology	0.70513840
92	MP0001905_abnormal_dopamine_level	0.70336427
93	MP0004145_abnormal_muscle_electrophysio	0.69376113
94	MP0003638_abnormal_response/metabolism_	0.69136469
95	MP0003861_abnormal_nervous_system	0.68925698
96	MP0008775_abnormal_heart_ventricle	0.68803403
97	MP0003959_abnormal_lean_body	0.68588113
98	MP0000049_abnormal_middle_ear	0.66823153
99	MP0004130_abnormal_muscle_cell	0.65162503
100	MP0002184_abnormal_innervation	0.64966297

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.49732135
2	Type II lissencephaly (HP:0007260)	4.24168266
3	Pancreatic cysts (HP:0001737)	3.90455947
4	Bile duct proliferation (HP:0001408)	3.72501398
5	Abnormal biliary tract physiology (HP:0012439)	3.72501398
6	Abnormality of lateral ventricle (HP:0030047)	3.68606902
7	Abnormality of midbrain morphology (HP:0002418)	3.54209042
8	Molar tooth sign on MRI (HP:0002419)	3.54209042
9	True hermaphroditism (HP:0010459)	3.48864265
10	Aplastic anemia (HP:0001915)	3.44165868
11	Abnormality of the renal cortex (HP:0011035)	3.30731420
12	Tubular atrophy (HP:0000092)	3.25059571
13	Nephronophthisis (HP:0000090)	3.10630447
14	Cerebellar dysplasia (HP:0007033)	3.01422926
15	Cystic liver disease (HP:0006706)	3.01396821
16	Progressive inability to walk (HP:0002505)	2.99031586
17	Abnormality of the renal medulla (HP:0100957)	2.94709796
18	Congenital stationary night blindness (HP:0007642)	2.91410264
19	Metaphyseal dysplasia (HP:0100255)	2.88933731
20	Abnormal drinking behavior (HP:0030082)	2.88292619
21	Polydipsia (HP:0001959)	2.88292619
22	Overriding aorta (HP:0002623)	2.86306009
23	Tubulointerstitial nephritis (HP:0001970)	2.82500345
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.70779872
25	Pendular nystagmus (HP:0012043)	2.69552073
26	Tubulointerstitial abnormality (HP:0001969)	2.68491813
27	Inability to walk (HP:0002540)	2.64427763
28	Hyperventilation (HP:0002883)	2.55216001
29	Disproportionate short-trunk short stature (HP:0003521)	2.55138359
30	Methylmalonic acidemia (HP:0002912)	2.53324379
31	Chronic hepatic failure (HP:0100626)	2.49813676
32	Pachygyria (HP:0001302)	2.47008507
33	Aqueductal stenosis (HP:0002410)	2.43779302
34	Abnormality of the carotid arteries (HP:0005344)	2.43561398
35	Abnormality of the ileum (HP:0001549)	2.42901035
36	Birth length less than 3rd percentile (HP:0003561)	2.41666776
37	Abnormality of alanine metabolism (HP:0010916)	2.41408918
38	Hyperalaninemia (HP:0003348)	2.41408918
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41408918
40	Polyuria (HP:0000103)	2.38644413
41	Neoplasm of head and neck (HP:0012288)	2.35067910
42	Esophageal neoplasm (HP:0100751)	2.35067910
43	B lymphocytopenia (HP:0010976)	2.34619658
44	Meckel diverticulum (HP:0002245)	2.34596245
45	Thyroiditis (HP:0100646)	2.33981544
46	Abolished electroretinogram (ERG) (HP:0000550)	2.33454784
47	Abnormality of the preputium (HP:0100587)	2.31423147
48	Chromsome breakage (HP:0040012)	2.27162305
49	Tubulointerstitial fibrosis (HP:0005576)	2.25221024
50	Abnormality of chromosome stability (HP:0003220)	2.24531153
51	Abnormality of B cell number (HP:0010975)	2.22248827
52	Severe combined immunodeficiency (HP:0004430)	2.20669719
53	Male pseudohermaphroditism (HP:0000037)	2.20665114
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20543503
55	Abnormal ciliary motility (HP:0012262)	2.19546145
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.17429984
57	Lissencephaly (HP:0001339)	2.15093702
58	Biliary tract neoplasm (HP:0100574)	2.13881160
59	Gaze-evoked nystagmus (HP:0000640)	2.13403012
60	Retinal dysplasia (HP:0007973)	2.13014554
61	Febrile seizures (HP:0002373)	2.12598489
62	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.11275511
63	Atonic seizures (HP:0010819)	2.09656033
64	Chorioretinal atrophy (HP:0000533)	2.08160006
65	Mesangial abnormality (HP:0001966)	2.05615188
66	Sclerocornea (HP:0000647)	2.04993384
67	Potter facies (HP:0002009)	2.02661161
68	Facial shape deformation (HP:0011334)	2.02661161
69	Hypothermia (HP:0002045)	2.01188259
70	Hypoglycemic coma (HP:0001325)	2.00191300
71	Abnormal biliary tract morphology (HP:0012440)	1.99084597
72	Postaxial foot polydactyly (HP:0001830)	1.97132111
73	Optic nerve hypoplasia (HP:0000609)	1.96586067
74	Delayed CNS myelination (HP:0002188)	1.96336528
75	Clubbing of toes (HP:0100760)	1.95768655
76	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.95707357
77	Hepatic necrosis (HP:0002605)	1.95001408
78	Drooling (HP:0002307)	1.94874425
79	Autoimmune thrombocytopenia (HP:0001973)	1.91151061
80	Ketosis (HP:0001946)	1.90965571
81	Ketoacidosis (HP:0001993)	1.90547349
82	Methylmalonic aciduria (HP:0012120)	1.90323945
83	Short tibia (HP:0005736)	1.89737392
84	Supernumerary spleens (HP:0009799)	1.89567389
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.89042202
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89004371
87	Broad-based gait (HP:0002136)	1.88786470
88	Attenuation of retinal blood vessels (HP:0007843)	1.88700505
89	Generalized aminoaciduria (HP:0002909)	1.88102079
90	Dandy-Walker malformation (HP:0001305)	1.88023649
91	Protruding tongue (HP:0010808)	1.87238804
92	Hyperglycinemia (HP:0002154)	1.87130638
93	Ependymoma (HP:0002888)	1.87015972
94	Medulloblastoma (HP:0002885)	1.86432380
95	Abnormal urine output (HP:0012590)	1.85986877
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84956379
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.84956379
98	Abnormality of macular pigmentation (HP:0008002)	1.83880146
99	Focal motor seizures (HP:0011153)	1.82620815
100	Neoplasm of the rectum (HP:0100743)	1.82593949

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.58564001
2	FRK	3.96628927
3	INSRR	3.83792018
4	NUAK1	3.48993141
5	EPHA3	3.07318145
6	TNIK	2.96051317
7	ACVR1B	2.68203976
8	EIF2AK3	2.62671371
9	MAPK13	2.45909828
10	MST4	2.36673277
11	WNK3	2.34677744
12	GRK1	2.21051960
13	CAMKK2	2.11618227
14	MAP3K14	1.85366250
15	MAP4K2	1.82725790
16	ADRBK2	1.80370719
17	PHKG2	1.80159820
18	PHKG1	1.80159820
19	LATS1	1.65573249
20	MARK1	1.61869965
21	ZAK	1.60454850
22	BRSK2	1.56458952
23	TLK1	1.50847352
24	TRIM28	1.47640682
25	STK39	1.46022157
26	STK16	1.41340917
27	BCR	1.36714122
28	AKT3	1.36031653
29	BMPR1B	1.24122174
30	PTK2B	1.22216498
31	PAK3	1.17917620
32	CASK	1.15266383
33	OXSR1	1.14326113
34	STK38L	1.04904041
35	TSSK6	0.94877971
36	CSNK1A1L	0.92052960
37	CSNK1G2	0.90828063
38	PINK1	0.89135834
39	EIF2AK2	0.88520547
40	WNK4	0.87365389
41	CSNK1G1	0.87264558
42	CSNK1G3	0.87233737
43	FLT3	0.85758416
44	RPS6KA5	0.82487802
45	BUB1	0.79413310
46	FGFR2	0.76754331
47	STK3	0.73392849
48	MAP3K4	0.73170323
49	PRKCE	0.70617192
50	DYRK2	0.69177586
51	NME1	0.68821757
52	LIMK1	0.68630252
53	VRK1	0.66476182
54	TGFBR1	0.64855973
55	CHUK	0.64157256
56	MAP3K2	0.64060511
57	CDK8	0.62033206
58	PKN1	0.62010705
59	PLK1	0.61855280
60	IKBKB	0.59989912
61	ABL2	0.59693796
62	MKNK1	0.58032465
63	PIK3CA	0.57694042
64	PRKCZ	0.53912334
65	NTRK2	0.53230350
66	PRKCQ	0.52946662
67	CSNK1A1	0.52097841
68	STK11	0.51551946
69	OBSCN	0.49629157
70	DYRK1A	0.49072290
71	CSNK1D	0.45571929
72	PRKAA2	0.42211228
73	ADRBK1	0.42089131
74	ATM	0.41238489
75	PRKAA1	0.39838230
76	SGK2	0.39453640
77	CHEK2	0.39445477
78	MAP2K7	0.38686062
79	SGK223	0.38503457
80	SGK494	0.38503457
81	MKNK2	0.37939469
82	PRKG1	0.37582009
83	PRKCG	0.36516396
84	MET	0.36357732
85	ATR	0.35382714
86	RPS6KB1	0.35038431
87	CAMK2A	0.34551186
88	AKT2	0.34396162
89	WEE1	0.34101097
90	PRKACA	0.32497195
91	DAPK2	0.31478111
92	CAMKK1	0.31396883
93	ABL1	0.30063966
94	EPHB2	0.28245056
95	CAMK4	0.27842820
96	EPHA4	0.26737483
97	PLK3	0.26576087
98	BRSK1	0.25713494
99	CAMK1	0.25603091
100	ERBB3	0.24365941

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.86601363
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.51892173
3	Tryptophan metabolism_Homo sapiens_hsa00380	3.09154128
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.92908517
5	Protein export_Homo sapiens_hsa03060	2.63738264
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.45848466
7	Caffeine metabolism_Homo sapiens_hsa00232	2.44708466
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43591112
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.32526009
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25432403
11	Homologous recombination_Homo sapiens_hsa03440	2.13238641
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.12689014
13	Nicotine addiction_Homo sapiens_hsa05033	2.07853190
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96286021
15	Mismatch repair_Homo sapiens_hsa03430	1.90855500
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88993454
17	RNA polymerase_Homo sapiens_hsa03020	1.82488175
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.71172577
19	Propanoate metabolism_Homo sapiens_hsa00640	1.70721840
20	Phototransduction_Homo sapiens_hsa04744	1.65139949
21	Taste transduction_Homo sapiens_hsa04742	1.62075907
22	Basal transcription factors_Homo sapiens_hsa03022	1.52989901
23	Olfactory transduction_Homo sapiens_hsa04740	1.44410403
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.41679226
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41541897
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39452453
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35037539
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.34733823
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34722604
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.31855315
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29394808
32	Alcoholism_Homo sapiens_hsa05034	1.28223963
33	Parkinsons disease_Homo sapiens_hsa05012	1.26680930
34	Circadian entrainment_Homo sapiens_hsa04713	1.26001966
35	Insulin secretion_Homo sapiens_hsa04911	1.22566708
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.20435513
37	Morphine addiction_Homo sapiens_hsa05032	1.10404996
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08391876
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07151127
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.06531944
41	Huntingtons disease_Homo sapiens_hsa05016	1.03686382
42	ABC transporters_Homo sapiens_hsa02010	0.98878809
43	Calcium signaling pathway_Homo sapiens_hsa04020	0.96642980
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.95473254
45	Axon guidance_Homo sapiens_hsa04360	0.95468615
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.93996310
47	Amphetamine addiction_Homo sapiens_hsa05031	0.92393576
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.91089992
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.89704888
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89614472
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89572369
52	RNA degradation_Homo sapiens_hsa03018	0.86273075
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.86272081
54	GABAergic synapse_Homo sapiens_hsa04727	0.83078780
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81051920
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80045076
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77727079
58	Lysine degradation_Homo sapiens_hsa00310	0.77151271
59	Cocaine addiction_Homo sapiens_hsa05030	0.76701971
60	Cholinergic synapse_Homo sapiens_hsa04725	0.76205042
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74374395
62	Alzheimers disease_Homo sapiens_hsa05010	0.72726599
63	Purine metabolism_Homo sapiens_hsa00230	0.71080348
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.69241953
65	Serotonergic synapse_Homo sapiens_hsa04726	0.68774626
66	Cell cycle_Homo sapiens_hsa04110	0.67721304
67	p53 signaling pathway_Homo sapiens_hsa04115	0.64953244
68	Salivary secretion_Homo sapiens_hsa04970	0.62317138
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.62277398
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62015642
71	Circadian rhythm_Homo sapiens_hsa04710	0.58617498
72	Retinol metabolism_Homo sapiens_hsa00830	0.58374860
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56628327
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56231709
75	Long-term depression_Homo sapiens_hsa04730	0.54863264
76	Fatty acid degradation_Homo sapiens_hsa00071	0.53555224
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49414814
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48603899
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46850895
80	Fatty acid elongation_Homo sapiens_hsa00062	0.44378414
81	Renin secretion_Homo sapiens_hsa04924	0.42742341
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41982015
83	Metabolic pathways_Homo sapiens_hsa01100	0.39204863
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38786480
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.38218123
86	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.37411401
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35523030
88	DNA replication_Homo sapiens_hsa03030	0.35074304
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34476717
90	Sulfur relay system_Homo sapiens_hsa04122	0.33385517
91	Proteasome_Homo sapiens_hsa03050	0.33141707
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31305533
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31270039
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.31211248
95	One carbon pool by folate_Homo sapiens_hsa00670	0.29891220
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.29886038
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28763268
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28724334
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.27897360
100	Oocyte meiosis_Homo sapiens_hsa04114	0.27690094

CBX3P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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