

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cytidine deamination (GO:0009972) | 7.66255660 |
| 2 | cytidine metabolic process (GO:0046087) | 7.66255660 |
| 3 | cytidine catabolic process (GO:0006216) | 7.66255660 |
| 4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.54901923 |
| 5 | DNA deamination (GO:0045006) | 7.39905090 |
| 6 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.60865470 |
| 7 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 5.69107916 |
| 8 | substrate-independent telencephalic tangential migration (GO:0021826) | 5.69107916 |
| 9 | dopamine transport (GO:0015872) | 5.24196324 |
| 10 | peristalsis (GO:0030432) | 5.17961480 |
| 11 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 4.87498291 |
| 12 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 4.87498291 |
| 13 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 4.74635740 |
| 14 | sequestering of actin monomers (GO:0042989) | 4.70424626 |
| 15 | proteasome assembly (GO:0043248) | 4.66427749 |
| 16 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.64741549 |
| 17 | ATP synthesis coupled proton transport (GO:0015986) | 4.64741549 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.61565444 |
| 19 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.58745953 |
| 20 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.55098343 |
| 21 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.55098343 |
| 22 | maturation of 5.8S rRNA (GO:0000460) | 4.43587213 |
| 23 | phasic smooth muscle contraction (GO:0014821) | 4.33232685 |
| 24 | respiratory electron transport chain (GO:0022904) | 4.03859150 |
| 25 | electron transport chain (GO:0022900) | 4.00384938 |
| 26 | cell proliferation in forebrain (GO:0021846) | 3.82479937 |
| 27 | ribosomal large subunit biogenesis (GO:0042273) | 3.78487503 |
| 28 | negative regulation by host of viral transcription (GO:0043922) | 3.73331737 |
| 29 | striatum development (GO:0021756) | 3.55329482 |
| 30 | regulation of neurotransmitter uptake (GO:0051580) | 3.51513706 |
| 31 | prepulse inhibition (GO:0060134) | 3.50072064 |
| 32 | regulation of dopamine metabolic process (GO:0042053) | 3.49508829 |
| 33 | regulation of catecholamine metabolic process (GO:0042069) | 3.49508829 |
| 34 | cullin deneddylation (GO:0010388) | 3.49369011 |
| 35 | macrophage chemotaxis (GO:0048246) | 3.49269476 |
| 36 | protein complex biogenesis (GO:0070271) | 3.45234566 |
| 37 | protein-cofactor linkage (GO:0018065) | 3.42873083 |
| 38 | platelet dense granule organization (GO:0060155) | 3.40975735 |
| 39 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.37822826 |
| 40 | protein deneddylation (GO:0000338) | 3.31063485 |
| 41 | synaptic transmission, dopaminergic (GO:0001963) | 3.26800404 |
| 42 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.24013743 |
| 43 | transmission of nerve impulse (GO:0019226) | 3.23406162 |
| 44 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.20545958 |
| 45 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.20342479 |
| 46 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.19980017 |
| 47 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.19980017 |
| 48 | NADH dehydrogenase complex assembly (GO:0010257) | 3.19980017 |
| 49 | maternal behavior (GO:0042711) | 3.17582003 |
| 50 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.14736463 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.14457038 |
| 52 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.13462842 |
| 53 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.13462842 |
| 54 | negative regulation of cAMP-mediated signaling (GO:0043951) | 3.13206458 |
| 55 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.12626406 |
| 56 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.12626406 |
| 57 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.12626406 |
| 58 | stem cell development (GO:0048864) | 3.11041440 |
| 59 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.11038961 |
| 60 | astrocyte development (GO:0014002) | 3.10331069 |
| 61 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.05680244 |
| 62 | regulation of synaptic transmission, dopaminergic (GO:0032225) | 3.02793964 |
| 63 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.00160987 |
| 64 | negative regulation of ligase activity (GO:0051352) | 3.00160987 |
| 65 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.96472475 |
| 66 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.96464255 |
| 67 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.96464255 |
| 68 | chaperone-mediated protein transport (GO:0072321) | 2.94070408 |
| 69 | grooming behavior (GO:0007625) | 2.89740650 |
| 70 | behavioral response to cocaine (GO:0048148) | 2.87878124 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.87671602 |
| 72 | parental behavior (GO:0060746) | 2.87088744 |
| 73 | actin nucleation (GO:0045010) | 2.86014547 |
| 74 | maturation of SSU-rRNA (GO:0030490) | 2.85241714 |
| 75 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.78994690 |
| 76 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.75932793 |
| 77 | catecholamine transport (GO:0051937) | 2.75149054 |
| 78 | cysteine metabolic process (GO:0006534) | 2.74734688 |
| 79 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G- | 2.74267539 |
| 80 | mating behavior (GO:0007617) | 2.73237634 |
| 81 | regulation of cellular amine metabolic process (GO:0033238) | 2.70246048 |
| 82 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.69938399 |
| 83 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.68430805 |
| 84 | termination of RNA polymerase III transcription (GO:0006386) | 2.68430805 |
| 85 | negative regulation of B cell proliferation (GO:0030889) | 2.66813046 |
| 86 | lens fiber cell development (GO:0070307) | 2.63818066 |
| 87 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 2.62321589 |
| 88 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.61183491 |
| 89 | ATP biosynthetic process (GO:0006754) | 2.59971794 |
| 90 | protein neddylation (GO:0045116) | 2.57583433 |
| 91 | positive regulation of cell cycle arrest (GO:0071158) | 2.55624586 |
| 92 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.54893910 |
| 93 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.54893910 |
| 94 | eosinophil chemotaxis (GO:0048245) | 2.53547610 |
| 95 | negative regulation of B cell activation (GO:0050869) | 2.52670247 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.51445352 |
| 97 | positive regulation of ligase activity (GO:0051351) | 2.50670864 |
| 98 | CENP-A containing nucleosome assembly (GO:0034080) | 2.49730682 |
| 99 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.48500766 |
| 100 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.44930724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 6.01008995 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.11802796 |
| 3 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.03449134 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.97535658 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.41043101 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.35330108 |
| 7 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.82468724 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.80949831 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.71511916 |
| 10 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.57581252 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.52353115 |
| 12 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.49597641 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.47305746 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.31858114 |
| 15 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.29786469 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.29486455 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.16775102 |
| 18 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.08718683 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.00781621 |
| 20 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.81982777 |
| 21 | GATA1_22025678_ChIP-Seq_K562_Human | 1.76388290 |
| 22 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.69305265 |
| 23 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.62893883 |
| 24 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.61898897 |
| 25 | FUS_26573619_Chip-Seq_HEK293_Human | 1.60585479 |
| 26 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.57513554 |
| 27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.56200359 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.55649475 |
| 29 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.55372036 |
| 30 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.52839948 |
| 31 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.49277033 |
| 32 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.48197756 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.47393151 |
| 34 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.46893098 |
| 35 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.43424563 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.41917050 |
| 37 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.40605474 |
| 38 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.36204228 |
| 39 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.32966000 |
| 40 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.32286382 |
| 41 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.32064882 |
| 42 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.32047203 |
| 43 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.32047203 |
| 44 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.30180223 |
| 45 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.28500145 |
| 46 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.24971561 |
| 47 | AR_20517297_ChIP-Seq_VCAP_Human | 1.24308298 |
| 48 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23758193 |
| 49 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.23573105 |
| 50 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.23145898 |
| 51 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.23122113 |
| 52 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.22911807 |
| 53 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.22911807 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22043888 |
| 55 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.21151384 |
| 56 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.17267974 |
| 57 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.16768901 |
| 58 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.13939557 |
| 59 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.13697815 |
| 60 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.07088982 |
| 61 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.06258806 |
| 62 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.05943734 |
| 63 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.05834018 |
| 64 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.04515612 |
| 65 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.04496899 |
| 66 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.03630856 |
| 67 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02761145 |
| 68 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02380441 |
| 69 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.01431896 |
| 70 | P300_19829295_ChIP-Seq_ESCs_Human | 1.00471645 |
| 71 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.00065912 |
| 72 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99938243 |
| 73 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.98657949 |
| 74 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.98149915 |
| 75 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.98067282 |
| 76 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97811466 |
| 77 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.96985389 |
| 78 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96786090 |
| 79 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96779919 |
| 80 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95427210 |
| 81 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94711913 |
| 82 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.94427510 |
| 83 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94276664 |
| 84 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.93327408 |
| 85 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.92679340 |
| 86 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.92511166 |
| 87 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.91366519 |
| 88 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.91242101 |
| 89 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.90177734 |
| 90 | JUN_21703547_ChIP-Seq_K562_Human | 0.89596933 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.88432644 |
| 92 | MYB_26560356_Chip-Seq_TH2_Human | 0.88342954 |
| 93 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.88108753 |
| 94 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.87459840 |
| 95 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.87206411 |
| 96 | GATA3_26560356_Chip-Seq_TH2_Human | 0.87089213 |
| 97 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.86977876 |
| 98 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.86614792 |
| 99 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.85748644 |
| 100 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.83605273 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 8.88702208 |
| 2 | MP0003136_yellow_coat_color | 4.39902998 |
| 3 | MP0005671_abnormal_response_to | 3.33889798 |
| 4 | MP0002102_abnormal_ear_morphology | 3.24959742 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 2.67302374 |
| 6 | MP0002234_abnormal_pharynx_morphology | 2.42495377 |
| 7 | MP0001188_hyperpigmentation | 2.34668592 |
| 8 | MP0005084_abnormal_gallbladder_morpholo | 2.18768475 |
| 9 | MP0009379_abnormal_foot_pigmentation | 2.14617217 |
| 10 | MP0004147_increased_porphyrin_level | 2.13908214 |
| 11 | MP0005646_abnormal_pituitary_gland | 2.08833181 |
| 12 | MP0002277_abnormal_respiratory_mucosa | 2.08704955 |
| 13 | MP0005645_abnormal_hypothalamus_physiol | 2.00604000 |
| 14 | MP0000372_irregular_coat_pigmentation | 1.99305231 |
| 15 | MP0006292_abnormal_olfactory_placode | 1.92086998 |
| 16 | MP0003011_delayed_dark_adaptation | 1.85575745 |
| 17 | MP0001529_abnormal_vocalization | 1.75972758 |
| 18 | MP0001485_abnormal_pinna_reflex | 1.75556192 |
| 19 | MP0009785_altered_susceptibility_to | 1.65563672 |
| 20 | MP0009697_abnormal_copulation | 1.63116251 |
| 21 | MP0005377_hearing/vestibular/ear_phenot | 1.49280567 |
| 22 | MP0003878_abnormal_ear_physiology | 1.49280567 |
| 23 | MP0001661_extended_life_span | 1.49131232 |
| 24 | MP0005367_renal/urinary_system_phenotyp | 1.48324526 |
| 25 | MP0000516_abnormal_urinary_system | 1.48324526 |
| 26 | MP0000631_abnormal_neuroendocrine_gland | 1.48066227 |
| 27 | MP0003567_abnormal_fetal_cardiomyocyte | 1.46689343 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.37906470 |
| 29 | MP0002166_altered_tumor_susceptibility | 1.37466777 |
| 30 | MP0004885_abnormal_endolymph | 1.37255265 |
| 31 | MP0002822_catalepsy | 1.34940295 |
| 32 | MP0008875_abnormal_xenobiotic_pharmacok | 1.29627708 |
| 33 | MP0009046_muscle_twitch | 1.26455613 |
| 34 | MP0002148_abnormal_hypersensitivity_rea | 1.24746786 |
| 35 | MP0002138_abnormal_hepatobiliary_system | 1.24230499 |
| 36 | MP0008995_early_reproductive_senescence | 1.22792389 |
| 37 | MP0003786_premature_aging | 1.22419671 |
| 38 | MP0002006_tumorigenesis | 1.22340337 |
| 39 | MP0001919_abnormal_reproductive_system | 1.20136298 |
| 40 | MP0002928_abnormal_bile_duct | 1.17269338 |
| 41 | MP0002837_dystrophic_cardiac_calcinosis | 1.17013355 |
| 42 | MP0003283_abnormal_digestive_organ | 1.16477731 |
| 43 | MP0009333_abnormal_splenocyte_physiolog | 1.14838286 |
| 44 | MP0001293_anophthalmia | 1.14145624 |
| 45 | MP0004142_abnormal_muscle_tone | 1.11300404 |
| 46 | MP0000026_abnormal_inner_ear | 1.10942718 |
| 47 | MP0001764_abnormal_homeostasis | 1.10435645 |
| 48 | MP0005389_reproductive_system_phenotype | 1.10315637 |
| 49 | MP0002751_abnormal_autonomic_nervous | 1.08756497 |
| 50 | MP0006072_abnormal_retinal_apoptosis | 1.08390613 |
| 51 | MP0002653_abnormal_ependyma_morphology | 1.07210953 |
| 52 | MP0001905_abnormal_dopamine_level | 1.06571129 |
| 53 | MP0001835_abnormal_antigen_presentation | 1.05379788 |
| 54 | MP0009764_decreased_sensitivity_to | 1.04817495 |
| 55 | MP0008872_abnormal_physiological_respon | 1.04377591 |
| 56 | MP0005253_abnormal_eye_physiology | 1.04216214 |
| 57 | MP0006036_abnormal_mitochondrial_physio | 1.01152496 |
| 58 | MP0002736_abnormal_nociception_after | 1.00590489 |
| 59 | MP0003183_abnormal_peptide_metabolism | 0.98255484 |
| 60 | MP0004215_abnormal_myocardial_fiber | 0.97704960 |
| 61 | MP0003137_abnormal_impulse_conducting | 0.92721370 |
| 62 | MP0003763_abnormal_thymus_physiology | 0.91970518 |
| 63 | MP0002163_abnormal_gland_morphology | 0.91520077 |
| 64 | MP0005670_abnormal_white_adipose | 0.89160178 |
| 65 | MP0000049_abnormal_middle_ear | 0.89042581 |
| 66 | MP0002160_abnormal_reproductive_system | 0.87153939 |
| 67 | MP0009765_abnormal_xenobiotic_induced | 0.86434472 |
| 68 | MP0000534_abnormal_ureter_morphology | 0.85546039 |
| 69 | MP0001800_abnormal_humoral_immune | 0.85130537 |
| 70 | MP0005167_abnormal_blood-brain_barrier | 0.83184813 |
| 71 | MP0001873_stomach_inflammation | 0.82859113 |
| 72 | MP0009250_abnormal_appendicular_skeleto | 0.82447035 |
| 73 | MP0000613_abnormal_salivary_gland | 0.81106607 |
| 74 | MP0005360_urolithiasis | 0.79400456 |
| 75 | MP0010386_abnormal_urinary_bladder | 0.79150577 |
| 76 | MP0002095_abnormal_skin_pigmentation | 0.77619864 |
| 77 | MP0004145_abnormal_muscle_electrophysio | 0.76952968 |
| 78 | MP0006276_abnormal_autonomic_nervous | 0.76812721 |
| 79 | MP0006054_spinal_hemorrhage | 0.75850537 |
| 80 | MP0003938_abnormal_ear_development | 0.75438612 |
| 81 | MP0005174_abnormal_tail_pigmentation | 0.72839431 |
| 82 | MP0003693_abnormal_embryo_hatching | 0.70503702 |
| 83 | MP0004957_abnormal_blastocyst_morpholog | 0.70230350 |
| 84 | MP0008873_increased_physiological_sensi | 0.70089300 |
| 85 | MP0005195_abnormal_posterior_eye | 0.67912296 |
| 86 | MP0002420_abnormal_adaptive_immunity | 0.67828516 |
| 87 | MP0009643_abnormal_urine_homeostasis | 0.67653948 |
| 88 | MP0002876_abnormal_thyroid_physiology | 0.67532012 |
| 89 | MP0009384_cardiac_valve_regurgitation | 0.67430041 |
| 90 | MP0002132_abnormal_respiratory_system | 0.66864652 |
| 91 | MP0005000_abnormal_immune_tolerance | 0.66093115 |
| 92 | MP0000778_abnormal_nervous_system | 0.64907553 |
| 93 | MP0009763_increased_sensitivity_to | 0.64551661 |
| 94 | MP0005025_abnormal_response_to | 0.63507148 |
| 95 | MP0001119_abnormal_female_reproductive | 0.63041030 |
| 96 | MP0006082_CNS_inflammation | 0.62176364 |
| 97 | MP0002638_abnormal_pupillary_reflex | 0.61806654 |
| 98 | MP0002184_abnormal_innervation | 0.61621404 |
| 99 | MP0001819_abnormal_immune_cell | 0.61206992 |
| 100 | MP0002723_abnormal_immune_serum | 0.60928623 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplasia/hypoplasia of the uterus (HP:0008684) | 4.52137031 |
| 2 | Fibular aplasia (HP:0002990) | 4.36728926 |
| 3 | Humeroradial synostosis (HP:0003041) | 4.19984655 |
| 4 | Synostosis involving the elbow (HP:0003938) | 4.19984655 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.04243745 |
| 6 | Oligodactyly (hands) (HP:0001180) | 3.88217411 |
| 7 | Split foot (HP:0001839) | 3.80516867 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.80160614 |
| 9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.77926511 |
| 10 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.77926511 |
| 11 | Aplastic anemia (HP:0001915) | 3.66430045 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.66135820 |
| 13 | Hypoplastic pelvis (HP:0008839) | 3.63131071 |
| 14 | Acute encephalopathy (HP:0006846) | 3.51594969 |
| 15 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.51483983 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.51461614 |
| 17 | Increased CSF lactate (HP:0002490) | 3.39075703 |
| 18 | Progressive macrocephaly (HP:0004481) | 3.28633068 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.28093480 |
| 20 | Increased hepatocellular lipid droplets (HP:0006565) | 3.27643604 |
| 21 | Type I transferrin isoform profile (HP:0003642) | 3.14277128 |
| 22 | Hepatic necrosis (HP:0002605) | 3.10501220 |
| 23 | Oligodactyly (HP:0012165) | 3.05825771 |
| 24 | Increased intramyocellular lipid droplets (HP:0012240) | 3.05122384 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 3.04963406 |
| 26 | Renal Fanconi syndrome (HP:0001994) | 2.96584322 |
| 27 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.95382918 |
| 28 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.90900970 |
| 29 | Abnormality of alanine metabolism (HP:0010916) | 2.90900970 |
| 30 | Hyperalaninemia (HP:0003348) | 2.90900970 |
| 31 | Abnormality of midbrain morphology (HP:0002418) | 2.75796080 |
| 32 | Molar tooth sign on MRI (HP:0002419) | 2.75796080 |
| 33 | Radial bowing (HP:0002986) | 2.72677412 |
| 34 | Increased muscle lipid content (HP:0009058) | 2.67959107 |
| 35 | Increased serum lactate (HP:0002151) | 2.66154947 |
| 36 | Increased IgM level (HP:0003496) | 2.66050827 |
| 37 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.62294929 |
| 38 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.58513541 |
| 39 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 2.57884311 |
| 40 | True hermaphroditism (HP:0010459) | 2.56431441 |
| 41 | Adactyly (HP:0009776) | 2.53690187 |
| 42 | Pancreatic cysts (HP:0001737) | 2.49692702 |
| 43 | Cerebral edema (HP:0002181) | 2.48300602 |
| 44 | Lactic acidosis (HP:0003128) | 2.44807178 |
| 45 | Generalized aminoaciduria (HP:0002909) | 2.43308095 |
| 46 | Congenital stationary night blindness (HP:0007642) | 2.42124765 |
| 47 | Pancreatic fibrosis (HP:0100732) | 2.38520438 |
| 48 | Exertional dyspnea (HP:0002875) | 2.34261553 |
| 49 | Parakeratosis (HP:0001036) | 2.28173350 |
| 50 | Decreased central vision (HP:0007663) | 2.27662092 |
| 51 | Constricted visual fields (HP:0001133) | 2.27041198 |
| 52 | Methylmalonic acidemia (HP:0002912) | 2.26735781 |
| 53 | Hemivertebrae (HP:0002937) | 2.19229734 |
| 54 | Methylmalonic aciduria (HP:0012120) | 2.16353553 |
| 55 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.14255350 |
| 56 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10153389 |
| 57 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.08279484 |
| 58 | Degeneration of anterior horn cells (HP:0002398) | 2.05644818 |
| 59 | Abnormality of the anterior horn cell (HP:0006802) | 2.05644818 |
| 60 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.04428367 |
| 61 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.04428367 |
| 62 | Abnormal protein glycosylation (HP:0012346) | 2.04428367 |
| 63 | Abnormal glycosylation (HP:0012345) | 2.04428367 |
| 64 | Sclerocornea (HP:0000647) | 2.01285562 |
| 65 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 2.00560831 |
| 66 | Abnormal finger flexion creases (HP:0006143) | 1.97872197 |
| 67 | IgG deficiency (HP:0004315) | 1.97845651 |
| 68 | Respiratory failure (HP:0002878) | 1.96067860 |
| 69 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.95308332 |
| 70 | Abnormality of renal resorption (HP:0011038) | 1.94753662 |
| 71 | T lymphocytopenia (HP:0005403) | 1.94498704 |
| 72 | Abnormality of T cell number (HP:0011839) | 1.92069029 |
| 73 | Optic disc pallor (HP:0000543) | 1.91144149 |
| 74 | Exercise intolerance (HP:0003546) | 1.89681688 |
| 75 | Pancytopenia (HP:0001876) | 1.89193305 |
| 76 | Hyperglycinemia (HP:0002154) | 1.88839963 |
| 77 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.86582408 |
| 78 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.86341841 |
| 79 | Leukodystrophy (HP:0002415) | 1.86313801 |
| 80 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.85386053 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.85113203 |
| 82 | Glycosuria (HP:0003076) | 1.85113203 |
| 83 | Lethargy (HP:0001254) | 1.81950320 |
| 84 | Pendular nystagmus (HP:0012043) | 1.80352018 |
| 85 | Abolished electroretinogram (ERG) (HP:0000550) | 1.79130893 |
| 86 | Absent forearm bone (HP:0003953) | 1.78812226 |
| 87 | Aplasia involving forearm bones (HP:0009822) | 1.78812226 |
| 88 | Homocystinuria (HP:0002156) | 1.77476321 |
| 89 | Abnormality of homocysteine metabolism (HP:0010919) | 1.77476321 |
| 90 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.77396619 |
| 91 | Genetic anticipation (HP:0003743) | 1.76748196 |
| 92 | Respiratory difficulties (HP:0002880) | 1.76557820 |
| 93 | Amniotic constriction ring (HP:0009775) | 1.75567399 |
| 94 | Abnormality of placental membranes (HP:0011409) | 1.75567399 |
| 95 | Abnormality of serum amino acid levels (HP:0003112) | 1.74586425 |
| 96 | Cystic liver disease (HP:0006706) | 1.74261242 |
| 97 | Attenuation of retinal blood vessels (HP:0007843) | 1.73502164 |
| 98 | Agitation (HP:0000713) | 1.72607488 |
| 99 | Patellar aplasia (HP:0006443) | 1.72166778 |
| 100 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.71239917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TLK1 | 4.34659140 |
| 2 | ZAK | 3.87882914 |
| 3 | KDR | 3.76181016 |
| 4 | TIE1 | 3.47295646 |
| 5 | TXK | 3.36985684 |
| 6 | TNIK | 3.21526141 |
| 7 | MAP4K2 | 2.93889525 |
| 8 | VRK1 | 2.73785108 |
| 9 | TESK2 | 2.57101958 |
| 10 | BUB1 | 2.42336014 |
| 11 | BMPR2 | 2.32018238 |
| 12 | MAP3K12 | 2.09733308 |
| 13 | NUAK1 | 2.04503898 |
| 14 | BCKDK | 1.97942843 |
| 15 | BMPR1B | 1.69168697 |
| 16 | TAOK3 | 1.68153163 |
| 17 | GRK1 | 1.67791145 |
| 18 | SRPK1 | 1.60978030 |
| 19 | ADRBK2 | 1.49849812 |
| 20 | MYLK | 1.48298667 |
| 21 | AURKA | 1.45520292 |
| 22 | MST4 | 1.44250234 |
| 23 | WNK4 | 1.33329703 |
| 24 | DAPK3 | 1.30265771 |
| 25 | DYRK2 | 1.27831172 |
| 26 | RPS6KA5 | 1.22901018 |
| 27 | FES | 1.07711085 |
| 28 | FRK | 1.07278710 |
| 29 | WEE1 | 1.03536188 |
| 30 | ERBB3 | 0.98635122 |
| 31 | PINK1 | 0.98343115 |
| 32 | CDK19 | 0.96318783 |
| 33 | EIF2AK3 | 0.94665097 |
| 34 | WNK3 | 0.91089171 |
| 35 | OXSR1 | 0.88575922 |
| 36 | PKN1 | 0.85532394 |
| 37 | PRKCQ | 0.83790994 |
| 38 | SCYL2 | 0.83389986 |
| 39 | MATK | 0.82381244 |
| 40 | MAP2K6 | 0.80350115 |
| 41 | NEK1 | 0.79175933 |
| 42 | CSNK1G2 | 0.76249325 |
| 43 | RPS6KA4 | 0.74203981 |
| 44 | SYK | 0.73134159 |
| 45 | AURKB | 0.72676232 |
| 46 | TEC | 0.71843951 |
| 47 | MAPK13 | 0.71279856 |
| 48 | ITK | 0.70937244 |
| 49 | CSF1R | 0.70693009 |
| 50 | KIT | 0.68688222 |
| 51 | ACVR1B | 0.65147529 |
| 52 | INSRR | 0.64939527 |
| 53 | VRK2 | 0.64774457 |
| 54 | MAPK15 | 0.64530619 |
| 55 | PAK4 | 0.64338154 |
| 56 | STK39 | 0.62396855 |
| 57 | ROCK1 | 0.61928210 |
| 58 | MAP2K7 | 0.60374390 |
| 59 | PLK4 | 0.60139988 |
| 60 | IKBKB | 0.59915058 |
| 61 | CSNK1G3 | 0.59342237 |
| 62 | LIMK1 | 0.58644543 |
| 63 | MAP4K1 | 0.58608311 |
| 64 | CDK8 | 0.55475840 |
| 65 | STK3 | 0.55131874 |
| 66 | MUSK | 0.55019734 |
| 67 | GRK7 | 0.54948080 |
| 68 | TRPM7 | 0.54785155 |
| 69 | LYN | 0.54389027 |
| 70 | AKT2 | 0.54145742 |
| 71 | TAF1 | 0.51955306 |
| 72 | CDK9 | 0.50550865 |
| 73 | TRIM28 | 0.50200582 |
| 74 | DYRK1A | 0.49511416 |
| 75 | PRKG2 | 0.48881480 |
| 76 | CSNK2A2 | 0.48060409 |
| 77 | ILK | 0.47452355 |
| 78 | EIF2AK2 | 0.47149555 |
| 79 | LCK | 0.45384506 |
| 80 | CSNK1A1 | 0.44589936 |
| 81 | PLK3 | 0.44370105 |
| 82 | CSNK2A1 | 0.44213460 |
| 83 | PIM1 | 0.44107341 |
| 84 | ADRBK1 | 0.43479991 |
| 85 | AKT3 | 0.42654211 |
| 86 | DAPK1 | 0.42424403 |
| 87 | OBSCN | 0.39084235 |
| 88 | ERBB2 | 0.37945108 |
| 89 | TESK1 | 0.37386098 |
| 90 | CAMK2A | 0.37182510 |
| 91 | NTRK2 | 0.37167195 |
| 92 | INSR | 0.37048802 |
| 93 | PRKCA | 0.36613407 |
| 94 | BCR | 0.36151792 |
| 95 | PDK2 | 0.35700202 |
| 96 | CAMK2D | 0.35598177 |
| 97 | DAPK2 | 0.34692752 |
| 98 | ATR | 0.34557889 |
| 99 | CAMK2B | 0.34542860 |
| 100 | CAMK2G | 0.33433049 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.36056259 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.83650256 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.62698078 |
| 4 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 3.36313670 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.74538387 |
| 6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.68334606 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.57855139 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.54307845 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.49230200 |
| 10 | Asthma_Homo sapiens_hsa05310 | 2.43684668 |
| 11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.22623565 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.21812762 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.13387120 |
| 14 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.10765556 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.08979287 |
| 16 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.07101187 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 2.06804146 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.03040251 |
| 19 | Alcoholism_Homo sapiens_hsa05034 | 1.96388287 |
| 20 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.81064754 |
| 21 | Phototransduction_Homo sapiens_hsa04744 | 1.72332334 |
| 22 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.59764417 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.52604573 |
| 24 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.45099714 |
| 25 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.43831397 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.43539759 |
| 27 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.31184629 |
| 28 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.22204806 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.20034794 |
| 30 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.15053918 |
| 31 | Viral myocarditis_Homo sapiens_hsa05416 | 1.13598115 |
| 32 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.10325701 |
| 33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.10178010 |
| 34 | Homologous recombination_Homo sapiens_hsa03440 | 1.05781706 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.05103376 |
| 36 | DNA replication_Homo sapiens_hsa03030 | 1.03285842 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.87631750 |
| 38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.85723386 |
| 39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.82964375 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.79252916 |
| 41 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.78435814 |
| 42 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.76650862 |
| 43 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.75668565 |
| 44 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.73990521 |
| 45 | Sulfur relay system_Homo sapiens_hsa04122 | 0.71939712 |
| 46 | Purine metabolism_Homo sapiens_hsa00230 | 0.71099495 |
| 47 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.70854334 |
| 48 | Olfactory transduction_Homo sapiens_hsa04740 | 0.70249556 |
| 49 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67836367 |
| 50 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.67186505 |
| 51 | Basal transcription factors_Homo sapiens_hsa03022 | 0.65675261 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64730319 |
| 53 | Morphine addiction_Homo sapiens_hsa05032 | 0.64681300 |
| 54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.62727983 |
| 55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.62376033 |
| 56 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61756469 |
| 57 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61381443 |
| 58 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.61288095 |
| 59 | RNA transport_Homo sapiens_hsa03013 | 0.60485668 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60352794 |
| 61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58389693 |
| 62 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.56461235 |
| 63 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.55788108 |
| 64 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.54799494 |
| 65 | Peroxisome_Homo sapiens_hsa04146 | 0.54330044 |
| 66 | RNA degradation_Homo sapiens_hsa03018 | 0.54061521 |
| 67 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.52939665 |
| 68 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.52352578 |
| 69 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.51132049 |
| 70 | Nicotine addiction_Homo sapiens_hsa05033 | 0.49510315 |
| 71 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.47937054 |
| 72 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.46514813 |
| 73 | Cocaine addiction_Homo sapiens_hsa05030 | 0.46350604 |
| 74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.46105447 |
| 75 | Taste transduction_Homo sapiens_hsa04742 | 0.45632862 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45278513 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.42311959 |
| 78 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.39079292 |
| 79 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.38952216 |
| 80 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.38911818 |
| 81 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.37379545 |
| 82 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.36801989 |
| 83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.35897036 |
| 84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.35766298 |
| 85 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.34285949 |
| 86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.33576806 |
| 87 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.33346466 |
| 88 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.33237177 |
| 89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32503974 |
| 90 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.32437640 |
| 91 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.32006090 |
| 92 | Leishmaniasis_Homo sapiens_hsa05140 | 0.31993956 |
| 93 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.29224693 |
| 94 | Salmonella infection_Homo sapiens_hsa05132 | 0.28802418 |
| 95 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26284773 |
| 96 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.26148875 |
| 97 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.25500282 |
| 98 | Malaria_Homo sapiens_hsa05144 | 0.25133796 |
| 99 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.24715025 |
| 100 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.23587442 |

