CBX3P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.66255660
2cytidine metabolic process (GO:0046087)7.66255660
3cytidine catabolic process (GO:0006216)7.66255660
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.54901923
5DNA deamination (GO:0045006)7.39905090
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.60865470
7substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.69107916
8substrate-independent telencephalic tangential migration (GO:0021826)5.69107916
9dopamine transport (GO:0015872)5.24196324
10peristalsis (GO:0030432)5.17961480
11regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.87498291
12regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.87498291
13phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.74635740
14sequestering of actin monomers (GO:0042989)4.70424626
15proteasome assembly (GO:0043248)4.66427749
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64741549
17ATP synthesis coupled proton transport (GO:0015986)4.64741549
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61565444
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58745953
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.55098343
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.55098343
22maturation of 5.8S rRNA (GO:0000460)4.43587213
23phasic smooth muscle contraction (GO:0014821)4.33232685
24respiratory electron transport chain (GO:0022904)4.03859150
25electron transport chain (GO:0022900)4.00384938
26cell proliferation in forebrain (GO:0021846)3.82479937
27ribosomal large subunit biogenesis (GO:0042273)3.78487503
28negative regulation by host of viral transcription (GO:0043922)3.73331737
29striatum development (GO:0021756)3.55329482
30regulation of neurotransmitter uptake (GO:0051580)3.51513706
31prepulse inhibition (GO:0060134)3.50072064
32regulation of dopamine metabolic process (GO:0042053)3.49508829
33regulation of catecholamine metabolic process (GO:0042069)3.49508829
34cullin deneddylation (GO:0010388)3.49369011
35macrophage chemotaxis (GO:0048246)3.49269476
36protein complex biogenesis (GO:0070271)3.45234566
37protein-cofactor linkage (GO:0018065)3.42873083
38platelet dense granule organization (GO:0060155)3.40975735
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.37822826
40protein deneddylation (GO:0000338)3.31063485
41synaptic transmission, dopaminergic (GO:0001963)3.26800404
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24013743
43transmission of nerve impulse (GO:0019226)3.23406162
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20545958
45pyrimidine nucleoside catabolic process (GO:0046135)3.20342479
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19980017
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.19980017
48NADH dehydrogenase complex assembly (GO:0010257)3.19980017
49maternal behavior (GO:0042711)3.17582003
50mitochondrial respiratory chain complex assembly (GO:0033108)3.14736463
51regulation of cellular amino acid metabolic process (GO:0006521)3.14457038
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13462842
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13462842
54negative regulation of cAMP-mediated signaling (GO:0043951)3.13206458
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12626406
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12626406
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12626406
58stem cell development (GO:0048864)3.11041440
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11038961
60astrocyte development (GO:0014002)3.10331069
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05680244
62regulation of synaptic transmission, dopaminergic (GO:0032225)3.02793964
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00160987
64negative regulation of ligase activity (GO:0051352)3.00160987
65signal transduction involved in cell cycle checkpoint (GO:0072395)2.96472475
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96464255
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.96464255
68chaperone-mediated protein transport (GO:0072321)2.94070408
69grooming behavior (GO:0007625)2.89740650
70behavioral response to cocaine (GO:0048148)2.87878124
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87671602
72parental behavior (GO:0060746)2.87088744
73actin nucleation (GO:0045010)2.86014547
74maturation of SSU-rRNA (GO:0030490)2.85241714
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78994690
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75932793
77catecholamine transport (GO:0051937)2.75149054
78cysteine metabolic process (GO:0006534)2.74734688
79positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.74267539
80mating behavior (GO:0007617)2.73237634
81regulation of cellular amine metabolic process (GO:0033238)2.70246048
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69938399
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.68430805
84termination of RNA polymerase III transcription (GO:0006386)2.68430805
85negative regulation of B cell proliferation (GO:0030889)2.66813046
86lens fiber cell development (GO:0070307)2.63818066
87negative regulation of oligodendrocyte differentiation (GO:0048715)2.62321589
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61183491
89ATP biosynthetic process (GO:0006754)2.59971794
90protein neddylation (GO:0045116)2.57583433
91positive regulation of cell cycle arrest (GO:0071158)2.55624586
92deoxyribose phosphate biosynthetic process (GO:0046385)2.54893910
932-deoxyribonucleotide biosynthetic process (GO:0009265)2.54893910
94eosinophil chemotaxis (GO:0048245)2.53547610
95negative regulation of B cell activation (GO:0050869)2.52670247
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.51445352
97positive regulation of ligase activity (GO:0051351)2.50670864
98CENP-A containing nucleosome assembly (GO:0034080)2.49730682
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48500766
100positive regulation of calcium-mediated signaling (GO:0050850)2.44930724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.01008995
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.11802796
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.03449134
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.97535658
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41043101
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.35330108
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.82468724
8VDR_22108803_ChIP-Seq_LS180_Human2.80949831
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.71511916
10ZNF274_21170338_ChIP-Seq_K562_Hela2.57581252
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52353115
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49597641
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47305746
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31858114
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29786469
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29486455
17VDR_23849224_ChIP-Seq_CD4+_Human2.16775102
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08718683
19ELK1_19687146_ChIP-ChIP_HELA_Human2.00781621
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.81982777
21GATA1_22025678_ChIP-Seq_K562_Human1.76388290
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69305265
23POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62893883
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.61898897
25FUS_26573619_Chip-Seq_HEK293_Human1.60585479
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57513554
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.56200359
28EWS_26573619_Chip-Seq_HEK293_Human1.55649475
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55372036
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52839948
31EZH2_22144423_ChIP-Seq_EOC_Human1.49277033
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48197756
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47393151
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.46893098
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.43424563
36FOXP3_21729870_ChIP-Seq_TREG_Human1.41917050
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40605474
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36204228
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32966000
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32286382
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32064882
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.32047203
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32047203
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30180223
45MYC_18940864_ChIP-ChIP_HL60_Human1.28500145
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24971561
47AR_20517297_ChIP-Seq_VCAP_Human1.24308298
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.23758193
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23573105
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23145898
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23122113
52NANOG_19829295_ChIP-Seq_ESCs_Human1.22911807
53SOX2_19829295_ChIP-Seq_ESCs_Human1.22911807
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22043888
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21151384
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17267974
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16768901
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13939557
59TP53_22573176_ChIP-Seq_HFKS_Human1.13697815
60RNF2_27304074_Chip-Seq_NSC_Mouse1.07088982
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06258806
62ERG_20517297_ChIP-Seq_VCAP_Human1.05943734
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05834018
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04515612
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04496899
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03630856
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.02761145
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02380441
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01431896
70P300_19829295_ChIP-Seq_ESCs_Human1.00471645
71IGF1R_20145208_ChIP-Seq_DFB_Human1.00065912
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99938243
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98657949
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98149915
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98067282
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97811466
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96985389
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96786090
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.96779919
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95427210
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94711913
82EED_16625203_ChIP-ChIP_MESCs_Mouse0.94427510
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94276664
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93327408
85TAF2_19829295_ChIP-Seq_ESCs_Human0.92679340
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92511166
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91366519
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.91242101
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90177734
90JUN_21703547_ChIP-Seq_K562_Human0.89596933
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88432644
92MYB_26560356_Chip-Seq_TH2_Human0.88342954
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88108753
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.87459840
95NANOG_20526341_ChIP-Seq_ESCs_Human0.87206411
96GATA3_26560356_Chip-Seq_TH2_Human0.87089213
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86977876
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86614792
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.85748644
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83605273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern8.88702208
2MP0003136_yellow_coat_color4.39902998
3MP0005671_abnormal_response_to3.33889798
4MP0002102_abnormal_ear_morphology3.24959742
5MP0003806_abnormal_nucleotide_metabolis2.67302374
6MP0002234_abnormal_pharynx_morphology2.42495377
7MP0001188_hyperpigmentation2.34668592
8MP0005084_abnormal_gallbladder_morpholo2.18768475
9MP0009379_abnormal_foot_pigmentation2.14617217
10MP0004147_increased_porphyrin_level2.13908214
11MP0005646_abnormal_pituitary_gland2.08833181
12MP0002277_abnormal_respiratory_mucosa2.08704955
13MP0005645_abnormal_hypothalamus_physiol2.00604000
14MP0000372_irregular_coat_pigmentation1.99305231
15MP0006292_abnormal_olfactory_placode1.92086998
16MP0003011_delayed_dark_adaptation1.85575745
17MP0001529_abnormal_vocalization1.75972758
18MP0001485_abnormal_pinna_reflex1.75556192
19MP0009785_altered_susceptibility_to1.65563672
20MP0009697_abnormal_copulation1.63116251
21MP0005377_hearing/vestibular/ear_phenot1.49280567
22MP0003878_abnormal_ear_physiology1.49280567
23MP0001661_extended_life_span1.49131232
24MP0005367_renal/urinary_system_phenotyp1.48324526
25MP0000516_abnormal_urinary_system1.48324526
26MP0000631_abnormal_neuroendocrine_gland1.48066227
27MP0003567_abnormal_fetal_cardiomyocyte1.46689343
28MP0005551_abnormal_eye_electrophysiolog1.37906470
29MP0002166_altered_tumor_susceptibility1.37466777
30MP0004885_abnormal_endolymph1.37255265
31MP0002822_catalepsy1.34940295
32MP0008875_abnormal_xenobiotic_pharmacok1.29627708
33MP0009046_muscle_twitch1.26455613
34MP0002148_abnormal_hypersensitivity_rea1.24746786
35MP0002138_abnormal_hepatobiliary_system1.24230499
36MP0008995_early_reproductive_senescence1.22792389
37MP0003786_premature_aging1.22419671
38MP0002006_tumorigenesis1.22340337
39MP0001919_abnormal_reproductive_system1.20136298
40MP0002928_abnormal_bile_duct1.17269338
41MP0002837_dystrophic_cardiac_calcinosis1.17013355
42MP0003283_abnormal_digestive_organ1.16477731
43MP0009333_abnormal_splenocyte_physiolog1.14838286
44MP0001293_anophthalmia1.14145624
45MP0004142_abnormal_muscle_tone1.11300404
46MP0000026_abnormal_inner_ear1.10942718
47MP0001764_abnormal_homeostasis1.10435645
48MP0005389_reproductive_system_phenotype1.10315637
49MP0002751_abnormal_autonomic_nervous1.08756497
50MP0006072_abnormal_retinal_apoptosis1.08390613
51MP0002653_abnormal_ependyma_morphology1.07210953
52MP0001905_abnormal_dopamine_level1.06571129
53MP0001835_abnormal_antigen_presentation1.05379788
54MP0009764_decreased_sensitivity_to1.04817495
55MP0008872_abnormal_physiological_respon1.04377591
56MP0005253_abnormal_eye_physiology1.04216214
57MP0006036_abnormal_mitochondrial_physio1.01152496
58MP0002736_abnormal_nociception_after1.00590489
59MP0003183_abnormal_peptide_metabolism0.98255484
60MP0004215_abnormal_myocardial_fiber0.97704960
61MP0003137_abnormal_impulse_conducting0.92721370
62MP0003763_abnormal_thymus_physiology0.91970518
63MP0002163_abnormal_gland_morphology0.91520077
64MP0005670_abnormal_white_adipose0.89160178
65MP0000049_abnormal_middle_ear0.89042581
66MP0002160_abnormal_reproductive_system0.87153939
67MP0009765_abnormal_xenobiotic_induced0.86434472
68MP0000534_abnormal_ureter_morphology0.85546039
69MP0001800_abnormal_humoral_immune0.85130537
70MP0005167_abnormal_blood-brain_barrier0.83184813
71MP0001873_stomach_inflammation0.82859113
72MP0009250_abnormal_appendicular_skeleto0.82447035
73MP0000613_abnormal_salivary_gland0.81106607
74MP0005360_urolithiasis0.79400456
75MP0010386_abnormal_urinary_bladder0.79150577
76MP0002095_abnormal_skin_pigmentation0.77619864
77MP0004145_abnormal_muscle_electrophysio0.76952968
78MP0006276_abnormal_autonomic_nervous0.76812721
79MP0006054_spinal_hemorrhage0.75850537
80MP0003938_abnormal_ear_development0.75438612
81MP0005174_abnormal_tail_pigmentation0.72839431
82MP0003693_abnormal_embryo_hatching0.70503702
83MP0004957_abnormal_blastocyst_morpholog0.70230350
84MP0008873_increased_physiological_sensi0.70089300
85MP0005195_abnormal_posterior_eye0.67912296
86MP0002420_abnormal_adaptive_immunity0.67828516
87MP0009643_abnormal_urine_homeostasis0.67653948
88MP0002876_abnormal_thyroid_physiology0.67532012
89MP0009384_cardiac_valve_regurgitation0.67430041
90MP0002132_abnormal_respiratory_system0.66864652
91MP0005000_abnormal_immune_tolerance0.66093115
92MP0000778_abnormal_nervous_system0.64907553
93MP0009763_increased_sensitivity_to0.64551661
94MP0005025_abnormal_response_to0.63507148
95MP0001119_abnormal_female_reproductive0.63041030
96MP0006082_CNS_inflammation0.62176364
97MP0002638_abnormal_pupillary_reflex0.61806654
98MP0002184_abnormal_innervation0.61621404
99MP0001819_abnormal_immune_cell0.61206992
100MP0002723_abnormal_immune_serum0.60928623

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/hypoplasia of the uterus (HP:0008684)4.52137031
2Fibular aplasia (HP:0002990)4.36728926
3Humeroradial synostosis (HP:0003041)4.19984655
4Synostosis involving the elbow (HP:0003938)4.19984655
5Mitochondrial inheritance (HP:0001427)4.04243745
6Oligodactyly (hands) (HP:0001180)3.88217411
7Split foot (HP:0001839)3.80516867
8Acute necrotizing encephalopathy (HP:0006965)3.80160614
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77926511
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77926511
11Aplastic anemia (HP:0001915)3.66430045
12Hepatocellular necrosis (HP:0001404)3.66135820
13Hypoplastic pelvis (HP:0008839)3.63131071
14Acute encephalopathy (HP:0006846)3.51594969
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.51483983
16Abnormal mitochondria in muscle tissue (HP:0008316)3.51461614
17Increased CSF lactate (HP:0002490)3.39075703
18Progressive macrocephaly (HP:0004481)3.28633068
19Lipid accumulation in hepatocytes (HP:0006561)3.28093480
20Increased hepatocellular lipid droplets (HP:0006565)3.27643604
21Type I transferrin isoform profile (HP:0003642)3.14277128
22Hepatic necrosis (HP:0002605)3.10501220
23Oligodactyly (HP:0012165)3.05825771
24Increased intramyocellular lipid droplets (HP:0012240)3.05122384
253-Methylglutaconic aciduria (HP:0003535)3.04963406
26Renal Fanconi syndrome (HP:0001994)2.96584322
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.95382918
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90900970
29Abnormality of alanine metabolism (HP:0010916)2.90900970
30Hyperalaninemia (HP:0003348)2.90900970
31Abnormality of midbrain morphology (HP:0002418)2.75796080
32Molar tooth sign on MRI (HP:0002419)2.75796080
33Radial bowing (HP:0002986)2.72677412
34Increased muscle lipid content (HP:0009058)2.67959107
35Increased serum lactate (HP:0002151)2.66154947
36Increased IgM level (HP:0003496)2.66050827
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62294929
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58513541
39Symphalangism affecting the phalanges of the hand (HP:0009773)2.57884311
40True hermaphroditism (HP:0010459)2.56431441
41Adactyly (HP:0009776)2.53690187
42Pancreatic cysts (HP:0001737)2.49692702
43Cerebral edema (HP:0002181)2.48300602
44Lactic acidosis (HP:0003128)2.44807178
45Generalized aminoaciduria (HP:0002909)2.43308095
46Congenital stationary night blindness (HP:0007642)2.42124765
47Pancreatic fibrosis (HP:0100732)2.38520438
48Exertional dyspnea (HP:0002875)2.34261553
49Parakeratosis (HP:0001036)2.28173350
50Decreased central vision (HP:0007663)2.27662092
51Constricted visual fields (HP:0001133)2.27041198
52Methylmalonic acidemia (HP:0002912)2.26735781
53Hemivertebrae (HP:0002937)2.19229734
54Methylmalonic aciduria (HP:0012120)2.16353553
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14255350
56Congenital, generalized hypertrichosis (HP:0004540)2.10153389
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08279484
58Degeneration of anterior horn cells (HP:0002398)2.05644818
59Abnormality of the anterior horn cell (HP:0006802)2.05644818
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04428367
61Abnormal protein N-linked glycosylation (HP:0012347)2.04428367
62Abnormal protein glycosylation (HP:0012346)2.04428367
63Abnormal glycosylation (HP:0012345)2.04428367
64Sclerocornea (HP:0000647)2.01285562
65Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.00560831
66Abnormal finger flexion creases (HP:0006143)1.97872197
67IgG deficiency (HP:0004315)1.97845651
68Respiratory failure (HP:0002878)1.96067860
69Elevated erythrocyte sedimentation rate (HP:0003565)1.95308332
70Abnormality of renal resorption (HP:0011038)1.94753662
71T lymphocytopenia (HP:0005403)1.94498704
72Abnormality of T cell number (HP:0011839)1.92069029
73Optic disc pallor (HP:0000543)1.91144149
74Exercise intolerance (HP:0003546)1.89681688
75Pancytopenia (HP:0001876)1.89193305
76Hyperglycinemia (HP:0002154)1.88839963
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.86582408
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86341841
79Leukodystrophy (HP:0002415)1.86313801
80Abnormal rod and cone electroretinograms (HP:0008323)1.85386053
81Abnormality of urine glucose concentration (HP:0011016)1.85113203
82Glycosuria (HP:0003076)1.85113203
83Lethargy (HP:0001254)1.81950320
84Pendular nystagmus (HP:0012043)1.80352018
85Abolished electroretinogram (ERG) (HP:0000550)1.79130893
86Absent forearm bone (HP:0003953)1.78812226
87Aplasia involving forearm bones (HP:0009822)1.78812226
88Homocystinuria (HP:0002156)1.77476321
89Abnormality of homocysteine metabolism (HP:0010919)1.77476321
90Aplasia/Hypoplasia of the patella (HP:0006498)1.77396619
91Genetic anticipation (HP:0003743)1.76748196
92Respiratory difficulties (HP:0002880)1.76557820
93Amniotic constriction ring (HP:0009775)1.75567399
94Abnormality of placental membranes (HP:0011409)1.75567399
95Abnormality of serum amino acid levels (HP:0003112)1.74586425
96Cystic liver disease (HP:0006706)1.74261242
97Attenuation of retinal blood vessels (HP:0007843)1.73502164
98Agitation (HP:0000713)1.72607488
99Patellar aplasia (HP:0006443)1.72166778
100Aplasia/Hypoplasia of the ulna (HP:0006495)1.71239917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.34659140
2ZAK3.87882914
3KDR3.76181016
4TIE13.47295646
5TXK3.36985684
6TNIK3.21526141
7MAP4K22.93889525
8VRK12.73785108
9TESK22.57101958
10BUB12.42336014
11BMPR22.32018238
12MAP3K122.09733308
13NUAK12.04503898
14BCKDK1.97942843
15BMPR1B1.69168697
16TAOK31.68153163
17GRK11.67791145
18SRPK11.60978030
19ADRBK21.49849812
20MYLK1.48298667
21AURKA1.45520292
22MST41.44250234
23WNK41.33329703
24DAPK31.30265771
25DYRK21.27831172
26RPS6KA51.22901018
27FES1.07711085
28FRK1.07278710
29WEE11.03536188
30ERBB30.98635122
31PINK10.98343115
32CDK190.96318783
33EIF2AK30.94665097
34WNK30.91089171
35OXSR10.88575922
36PKN10.85532394
37PRKCQ0.83790994
38SCYL20.83389986
39MATK0.82381244
40MAP2K60.80350115
41NEK10.79175933
42CSNK1G20.76249325
43RPS6KA40.74203981
44SYK0.73134159
45AURKB0.72676232
46TEC0.71843951
47MAPK130.71279856
48ITK0.70937244
49CSF1R0.70693009
50KIT0.68688222
51ACVR1B0.65147529
52INSRR0.64939527
53VRK20.64774457
54MAPK150.64530619
55PAK40.64338154
56STK390.62396855
57ROCK10.61928210
58MAP2K70.60374390
59PLK40.60139988
60IKBKB0.59915058
61CSNK1G30.59342237
62LIMK10.58644543
63MAP4K10.58608311
64CDK80.55475840
65STK30.55131874
66MUSK0.55019734
67GRK70.54948080
68TRPM70.54785155
69LYN0.54389027
70AKT20.54145742
71TAF10.51955306
72CDK90.50550865
73TRIM280.50200582
74DYRK1A0.49511416
75PRKG20.48881480
76CSNK2A20.48060409
77ILK0.47452355
78EIF2AK20.47149555
79LCK0.45384506
80CSNK1A10.44589936
81PLK30.44370105
82CSNK2A10.44213460
83PIM10.44107341
84ADRBK10.43479991
85AKT30.42654211
86DAPK10.42424403
87OBSCN0.39084235
88ERBB20.37945108
89TESK10.37386098
90CAMK2A0.37182510
91NTRK20.37167195
92INSR0.37048802
93PRKCA0.36613407
94BCR0.36151792
95PDK20.35700202
96CAMK2D0.35598177
97DAPK20.34692752
98ATR0.34557889
99CAMK2B0.34542860
100CAMK2G0.33433049

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36056259
2Oxidative phosphorylation_Homo sapiens_hsa001903.83650256
3Parkinsons disease_Homo sapiens_hsa050123.62698078
4Systemic lupus erythematosus_Homo sapiens_hsa053223.36313670
5Ribosome_Homo sapiens_hsa030102.74538387
6Graft-versus-host disease_Homo sapiens_hsa053322.68334606
7Autoimmune thyroid disease_Homo sapiens_hsa053202.57855139
8Protein export_Homo sapiens_hsa030602.54307845
9Allograft rejection_Homo sapiens_hsa053302.49230200
10Asthma_Homo sapiens_hsa053102.43684668
11Primary immunodeficiency_Homo sapiens_hsa053402.22623565
12Alzheimers disease_Homo sapiens_hsa050102.21812762
13Huntingtons disease_Homo sapiens_hsa050162.13387120
14Antigen processing and presentation_Homo sapiens_hsa046122.10765556
15Type I diabetes mellitus_Homo sapiens_hsa049402.08979287
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.07101187
17RNA polymerase_Homo sapiens_hsa030202.06804146
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03040251
19Alcoholism_Homo sapiens_hsa050341.96388287
20Cardiac muscle contraction_Homo sapiens_hsa042601.81064754
21Phototransduction_Homo sapiens_hsa047441.72332334
22Rheumatoid arthritis_Homo sapiens_hsa053231.59764417
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52604573
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.45099714
25Sulfur metabolism_Homo sapiens_hsa009201.43831397
26One carbon pool by folate_Homo sapiens_hsa006701.43539759
27Nitrogen metabolism_Homo sapiens_hsa009101.31184629
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22204806
29Propanoate metabolism_Homo sapiens_hsa006401.20034794
30Hematopoietic cell lineage_Homo sapiens_hsa046401.15053918
31Viral myocarditis_Homo sapiens_hsa054161.13598115
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10325701
33Collecting duct acid secretion_Homo sapiens_hsa049661.10178010
34Homologous recombination_Homo sapiens_hsa034401.05781706
35Spliceosome_Homo sapiens_hsa030401.05103376
36DNA replication_Homo sapiens_hsa030301.03285842
37Pyrimidine metabolism_Homo sapiens_hsa002400.87631750
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85723386
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.82964375
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79252916
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78435814
42Staphylococcus aureus infection_Homo sapiens_hsa051500.76650862
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75668565
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73990521
45Sulfur relay system_Homo sapiens_hsa041220.71939712
46Purine metabolism_Homo sapiens_hsa002300.71099495
47Fanconi anemia pathway_Homo sapiens_hsa034600.70854334
48Olfactory transduction_Homo sapiens_hsa047400.70249556
49Linoleic acid metabolism_Homo sapiens_hsa005910.67836367
50Vitamin digestion and absorption_Homo sapiens_hsa049770.67186505
51Basal transcription factors_Homo sapiens_hsa030220.65675261
52Selenocompound metabolism_Homo sapiens_hsa004500.64730319
53Morphine addiction_Homo sapiens_hsa050320.64681300
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62727983
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62376033
56Chemical carcinogenesis_Homo sapiens_hsa052040.61756469
57Retinol metabolism_Homo sapiens_hsa008300.61381443
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61288095
59RNA transport_Homo sapiens_hsa030130.60485668
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60352794
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58389693
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56461235
63Arginine biosynthesis_Homo sapiens_hsa002200.55788108
64Hedgehog signaling pathway_Homo sapiens_hsa043400.54799494
65Peroxisome_Homo sapiens_hsa041460.54330044
66RNA degradation_Homo sapiens_hsa030180.54061521
67Regulation of autophagy_Homo sapiens_hsa041400.52939665
68Nucleotide excision repair_Homo sapiens_hsa034200.52352578
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51132049
70Nicotine addiction_Homo sapiens_hsa050330.49510315
71Butanoate metabolism_Homo sapiens_hsa006500.47937054
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46514813
73Cocaine addiction_Homo sapiens_hsa050300.46350604
74Pyruvate metabolism_Homo sapiens_hsa006200.46105447
75Taste transduction_Homo sapiens_hsa047420.45632862
76Metabolic pathways_Homo sapiens_hsa011000.45278513
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42311959
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.39079292
79Tryptophan metabolism_Homo sapiens_hsa003800.38952216
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38911818
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37379545
82Amphetamine addiction_Homo sapiens_hsa050310.36801989
83mRNA surveillance pathway_Homo sapiens_hsa030150.35897036
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35766298
85Renin-angiotensin system_Homo sapiens_hsa046140.34285949
86Glutathione metabolism_Homo sapiens_hsa004800.33576806
87African trypanosomiasis_Homo sapiens_hsa051430.33346466
88Folate biosynthesis_Homo sapiens_hsa007900.33237177
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32503974
90Epstein-Barr virus infection_Homo sapiens_hsa051690.32437640
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32006090
92Leishmaniasis_Homo sapiens_hsa051400.31993956
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29224693
94Salmonella infection_Homo sapiens_hsa051320.28802418
95T cell receptor signaling pathway_Homo sapiens_hsa046600.26284773
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26148875
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25500282
98Malaria_Homo sapiens_hsa051440.25133796
99Caffeine metabolism_Homo sapiens_hsa002320.24715025
100Dopaminergic synapse_Homo sapiens_hsa047280.23587442

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