ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.41930959
2	DNA unwinding involved in DNA replication (GO:0006268)	4.76556490
3	protein localization to kinetochore (GO:0034501)	4.75214164
4	sister chromatid segregation (GO:0000819)	4.66874792
5	nuclear pore organization (GO:0006999)	4.59675270
6	nuclear pore complex assembly (GO:0051292)	4.53783747
7	kinetochore organization (GO:0051383)	4.38577154
8	mitotic sister chromatid segregation (GO:0000070)	4.34744523
9	mitotic sister chromatid cohesion (GO:0007064)	4.18975067
10	pyrimidine nucleobase catabolic process (GO:0006208)	4.13555253
11	mitotic chromosome condensation (GO:0007076)	4.10753988
12	DNA topological change (GO:0006265)	3.95003450
13	protein localization to chromosome, centromeric region (GO:0071459)	3.83166074
14	presynaptic membrane assembly (GO:0097105)	3.80470457
15	CENP-A containing nucleosome assembly (GO:0034080)	3.74910674
16	mitotic metaphase plate congression (GO:0007080)	3.73363458
17	chromatin remodeling at centromere (GO:0031055)	3.67214672
18	pre-miRNA processing (GO:0031054)	3.62882589
19	kinetochore assembly (GO:0051382)	3.57864312
20	mitotic nuclear envelope disassembly (GO:0007077)	3.53969253
21	DNA replication-dependent nucleosome assembly (GO:0006335)	3.51545414
22	DNA replication-dependent nucleosome organization (GO:0034723)	3.51545414
23	DNA replication-independent nucleosome organization (GO:0034724)	3.49582813
24	DNA replication-independent nucleosome assembly (GO:0006336)	3.49582813
25	mitotic recombination (GO:0006312)	3.47525665
26	DNA strand elongation involved in DNA replication (GO:0006271)	3.46310467
27	metaphase plate congression (GO:0051310)	3.44106290
28	paraxial mesoderm development (GO:0048339)	3.43893768
29	pore complex assembly (GO:0046931)	3.40708194
30	regulation of sister chromatid cohesion (GO:0007063)	3.40011165
31	spindle checkpoint (GO:0031577)	3.38877921
32	IMP biosynthetic process (GO:0006188)	3.36892752
33	DNA replication initiation (GO:0006270)	3.36871418
34	DNA geometric change (GO:0032392)	3.36206082
35	regulation of DNA endoreduplication (GO:0032875)	3.36138979
36	DNA duplex unwinding (GO:0032508)	3.34982162
37	membrane disassembly (GO:0030397)	3.34708651
38	nuclear envelope disassembly (GO:0051081)	3.34708651
39	regulation of centriole replication (GO:0046599)	3.33013909
40	attachment of spindle microtubules to kinetochore (GO:0008608)	3.32130483
41	DNA strand elongation (GO:0022616)	3.32048690
42	meiotic chromosome segregation (GO:0045132)	3.30726822
43	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.29832280
44	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.29832280
45	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.29832280
46	negative regulation of DNA repair (GO:0045738)	3.29225449
47	histone exchange (GO:0043486)	3.27582967
48	nucleobase catabolic process (GO:0046113)	3.27492810
49	glucocorticoid receptor signaling pathway (GO:0042921)	3.26613817
50	presynaptic membrane organization (GO:0097090)	3.26208350
51	telomere maintenance via semi-conservative replication (GO:0032201)	3.24665946
52	regulation of centrosome cycle (GO:0046605)	3.21915685
53	spindle assembly checkpoint (GO:0071173)	3.21324941
54	establishment of chromosome localization (GO:0051303)	3.21218107
55	negative regulation of chromosome segregation (GO:0051985)	3.17834104
56	double-strand break repair via nonhomologous end joining (GO:0006303)	3.16244340
57	non-recombinational repair (GO:0000726)	3.16244340
58	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.16211403
59	regulation of spindle organization (GO:0090224)	3.15796694
60	mitotic spindle checkpoint (GO:0071174)	3.15750485
61	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.15009787
62	regulation of centrosome duplication (GO:0010824)	3.14975072
63	DNA strand renaturation (GO:0000733)	3.14850705
64	chromosome segregation (GO:0007059)	3.14532641
65	negative regulation of DNA recombination (GO:0045910)	3.13912953
66	regulation of mitotic sister chromatid segregation (GO:0033047)	3.13239033
67	regulation of sister chromatid segregation (GO:0033045)	3.13239033
68	regulation of mitotic sister chromatid separation (GO:0010965)	3.13239033
69	regulation of chromosome segregation (GO:0051983)	3.12808525
70	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.11827120
71	negative regulation of sister chromatid segregation (GO:0033046)	3.11827120
72	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.11827120
73	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.11827120
74	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.11544976
75	mitotic spindle assembly checkpoint (GO:0007094)	3.10151255
76	establishment of integrated proviral latency (GO:0075713)	3.09661607
77	nucleobase biosynthetic process (GO:0046112)	3.08545546
78	DNA double-strand break processing (GO:0000729)	3.08459901
79	telomere maintenance via recombination (GO:0000722)	3.07651586
80	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.07627088
81	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.07355675
82	positive regulation of chromosome segregation (GO:0051984)	3.04914000
83	dosage compensation (GO:0007549)	3.03751118
84	protein localization to chromosome (GO:0034502)	3.03663711
85	ATP-dependent chromatin remodeling (GO:0043044)	3.03532217
86	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.01765236
87	replication fork processing (GO:0031297)	3.01314802
88	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.00495715
89	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.96458920
90	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.96458920
91	postreplication repair (GO:0006301)	2.93726607
92	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.93722360
93	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.93722360
94	regulation of translation, ncRNA-mediated (GO:0045974)	2.93722360
95	DNA conformation change (GO:0071103)	2.93530643
96	chromatin assembly or disassembly (GO:0006333)	2.92558965
97	regulation of double-strand break repair (GO:2000779)	2.89495220
98	regulation of histone H3-K9 methylation (GO:0051570)	2.86556261
99	purine nucleobase biosynthetic process (GO:0009113)	2.84730766
100	chromosome condensation (GO:0030261)	2.84424203
101	resolution of meiotic recombination intermediates (GO:0000712)	2.84230351
102	regulation of RNA export from nucleus (GO:0046831)	2.83900010
103	olfactory bulb development (GO:0021772)	2.82385697
104	limb bud formation (GO:0060174)	2.81170904
105	microtubule depolymerization (GO:0007019)	2.80881037
106	DNA ligation (GO:0006266)	2.78830377
107	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.78708558
108	DNA replication checkpoint (GO:0000076)	2.75867451
109	regulation of mitotic spindle organization (GO:0060236)	2.74906753
110	histone H2A acetylation (GO:0043968)	2.74248392
111	translesion synthesis (GO:0019985)	2.74200580
112	negative regulation of mRNA processing (GO:0050686)	2.73789087
113	IMP metabolic process (GO:0046040)	2.73290057
114	viral mRNA export from host cell nucleus (GO:0046784)	2.72485698
115	DNA packaging (GO:0006323)	2.72405170
116	neuron cell-cell adhesion (GO:0007158)	2.62542818
117	retinal ganglion cell axon guidance (GO:0031290)	2.58448818
118	microtubule polymerization or depolymerization (GO:0031109)	2.56678677
119	mitotic spindle organization (GO:0007052)	2.52324592
120	regulation of mitotic spindle checkpoint (GO:1903504)	2.49761239
121	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.49761239
122	centriole replication (GO:0007099)	2.48322156
123	DNA damage response, detection of DNA damage (GO:0042769)	2.46687637
124	V(D)J recombination (GO:0033151)	2.46463670
125	regulation of helicase activity (GO:0051095)	2.46267061
126	postsynaptic membrane organization (GO:0001941)	2.37632979
127	L-serine metabolic process (GO:0006563)	2.37484798
128	intraciliary transport (GO:0042073)	2.36045086
129	nonmotile primary cilium assembly (GO:0035058)	2.35111036
130	microtubule anchoring (GO:0034453)	2.32727723
131	axonal fasciculation (GO:0007413)	2.28621438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	5.91177552
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.86725713
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.69391632
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.67988349
5	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.54987959
6	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	3.36458354
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.31600057
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.05839689
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.54646789
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.49302267
11	* E2F1_21310950_ChIP-Seq_MCF-7_Human	2.45609407
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44440993
13	AR_21909140_ChIP-Seq_LNCAP_Human	2.42849880
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26052408
15	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.23360484
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22660291
17	GBX2_23144817_ChIP-Seq_PC3_Human	2.20584053
18	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.14979086
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.12749729
20	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.10375491
21	TAF15_26573619_Chip-Seq_HEK293_Human	2.08600523
22	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08357768
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05687539
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.03917418
25	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.01686658
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00252430
27	E2F7_22180533_ChIP-Seq_HELA_Human	10.9626868
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94383344
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.92047510
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90365335
31	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.89574159
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.89502580
33	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.86707256
34	* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.82784412
35	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.75258620
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74031202
37	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.69524396
38	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.69431887
39	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69208662
40	P300_19829295_ChIP-Seq_ESCs_Human	1.67305774
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66172244
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.61310324
43	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59652351
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.56580892
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.55322736
46	XRN2_22483619_ChIP-Seq_HELA_Human	1.54925243
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.50761817
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50228014
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50120387
50	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.46891246
51	FUS_26573619_Chip-Seq_HEK293_Human	1.45219732
52	* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43703069
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43514376
54	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.42211988
55	* EWS_26573619_Chip-Seq_HEK293_Human	1.41677375
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.41370460
57	* SOX2_16153702_ChIP-ChIP_HESCs_Human	1.40034422
58	VDR_22108803_ChIP-Seq_LS180_Human	1.39206935
59	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.39205511
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37970382
61	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.37669729
62	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.36952809
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35785650
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.33834662
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.33302647
66	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32817640
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31405818
68	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.29242805
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28566494
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28179932
71	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25612838
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24962173
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24430916
74	* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24313355
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23189937
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22495123
77	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21487868
78	* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21475018
79	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19509730
80	* NANOG_21062744_ChIP-ChIP_HESCs_Human	1.18764862
81	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.18457332
82	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.17052412
83	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16566433
84	* NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16481760
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.16294272
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.16251391
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15883418
88	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.14638552
89	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.12920777
90	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12798551
91	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11473969
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11151263
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10268181
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10268181
95	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.08944589
96	KDM5A_27292631_Chip-Seq_BREAST_Human	1.07462333
97	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07305340
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.05669386
99	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05516247
100	* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.05183590
101	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04926584
102	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04408357
103	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.03767074
104	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.03600828
105	STAT3_23295773_ChIP-Seq_U87_Human	1.03599661
106	* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03217980
107	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02353183
108	* GABP_19822575_ChIP-Seq_HepG2_Human	1.01406665
109	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01037187
110	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99580942
111	CBP_20019798_ChIP-Seq_JUKART_Human	0.99580942
112	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.99230165
113	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.98912008
114	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.96743991
115	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96184833
116	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.95677561
117	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95625972
118	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.95430726
119	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.94951460
120	AR_25329375_ChIP-Seq_VCAP_Human	0.94097843
121	* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.94041255
122	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93675094
123	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.93460682
124	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91897475
125	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.91438158
126	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.91188313
127	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91181830
128	* SOX9_26525672_Chip-Seq_HEART_Mouse	0.90430913
129	* TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.90014250
130	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.89849639
131	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.89456906
132	ER_23166858_ChIP-Seq_MCF-7_Human	0.89298027
133	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.89219812
134	* DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.88899573
135	TCF4_23295773_ChIP-Seq_U87_Human	0.88265622
136	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.87504381
137	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.86783667
138	MYC_22102868_ChIP-Seq_BL_Human	0.86467734
139	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.84408052
140	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84288147
141	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.81302163
142	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.81104868
143	* MYC_18940864_ChIP-ChIP_HL60_Human	0.80174223
144	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.79599544
145	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.79061068
146	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.75577596
147	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.75508496
148	CHD1_26751641_Chip-Seq_LNCaP_Human	0.74537086
149	* NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.73813869
150	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.71868027
151	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.70901833

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.51158341
2	MP0003123_paternal_imprinting	3.39970205
3	MP0003121_genomic_imprinting	3.23982523
4	MP0003122_maternal_imprinting	3.03136775
5	MP0008057_abnormal_DNA_replication	2.95787215
6	MP0003111_abnormal_nucleus_morphology	2.86226134
7	MP0003077_abnormal_cell_cycle	2.61790402
8	MP0010030_abnormal_orbit_morphology	2.52718075
9	MP0000537_abnormal_urethra_morphology	2.42331810
10	MP0004957_abnormal_blastocyst_morpholog	2.41024050
11	MP0009053_abnormal_anal_canal	2.39554596
12	MP0003693_abnormal_embryo_hatching	2.26986531
13	MP0003787_abnormal_imprinting	2.24992152
14	MP0002102_abnormal_ear_morphology	2.18080485
15	MP0008007_abnormal_cellular_replicative	2.14882069
16	MP0003880_abnormal_central_pattern	2.12514860
17	MP0008058_abnormal_DNA_repair	2.01181070
18	MP0003890_abnormal_embryonic-extraembry	2.00513299
19	MP0008877_abnormal_DNA_methylation	2.00395339
20	MP0001529_abnormal_vocalization	1.94131783
21	MP0008932_abnormal_embryonic_tissue	1.84694639
22	MP0001730_embryonic_growth_arrest	1.70230709
23	MP0003385_abnormal_body_wall	1.69568007
24	MP0004197_abnormal_fetal_growth/weight/	1.67556173
25	MP0003119_abnormal_digestive_system	1.66286206
26	MP0003937_abnormal_limbs/digits/tail_de	1.64157187
27	MP0000350_abnormal_cell_proliferation	1.63711055
28	MP0001293_anophthalmia	1.63482218
29	MP0003942_abnormal_urinary_system	1.63295540
30	MP0001672_abnormal_embryogenesis/_devel	1.62733714
31	MP0005380_embryogenesis_phenotype	1.62733714
32	MP0006072_abnormal_retinal_apoptosis	1.62345361
33	MP0000569_abnormal_digit_pigmentation	1.61783762
34	MP0003567_abnormal_fetal_cardiomyocyte	1.61699405
35	MP0002084_abnormal_developmental_patter	1.60119406
36	MP0002085_abnormal_embryonic_tissue	1.58295028
37	MP0001697_abnormal_embryo_size	1.57829253
38	MP0003984_embryonic_growth_retardation	1.52298324
39	MP0001984_abnormal_olfaction	1.52057322
40	MP0003136_yellow_coat_color	1.50804711
41	MP0002088_abnormal_embryonic_growth/wei	1.50025624
42	MP0003115_abnormal_respiratory_system	1.46208089
43	MP0003941_abnormal_skin_development	1.44250200
44	MP0000516_abnormal_urinary_system	1.42074116
45	MP0005367_renal/urinary_system_phenotyp	1.42074116
46	MP0010352_gastrointestinal_tract_polyps	1.40338869
47	MP0002234_abnormal_pharynx_morphology	1.39914890
48	MP0002938_white_spotting	1.38777442
49	MP0001299_abnormal_eye_distance/	1.36383849
50	MP0000049_abnormal_middle_ear	1.36339295
51	MP0005076_abnormal_cell_differentiation	1.35177406
52	MP0004233_abnormal_muscle_weight	1.34559146
53	MP0001188_hyperpigmentation	1.34217693
54	MP0000566_synostosis	1.33629753
55	MP0003315_abnormal_perineum_morphology	1.31991321
56	MP0002086_abnormal_extraembryonic_tissu	1.31297303
57	MP0003755_abnormal_palate_morphology	1.30141657
58	MP0005248_abnormal_Harderian_gland	1.29983235
59	MP0003935_abnormal_craniofacial_develop	1.28603016
60	MP0005253_abnormal_eye_physiology	1.27571279
61	MP0006276_abnormal_autonomic_nervous	1.26247105
62	MP0004270_analgesia	1.25914482
63	MP0009250_abnormal_appendicular_skeleto	1.24717210
64	MP0002249_abnormal_larynx_morphology	1.24299762
65	MP0000534_abnormal_ureter_morphology	1.21693186
66	MP0001177_atelectasis	1.21591866
67	MP0008789_abnormal_olfactory_epithelium	1.20691976
68	MP0002080_prenatal_lethality	1.18916287
69	MP0010307_abnormal_tumor_latency	1.18079774
70	MP0000428_abnormal_craniofacial_morphol	1.17261738
71	MP0003861_abnormal_nervous_system	1.17140528
72	MP0002184_abnormal_innervation	1.14106821
73	MP0005391_vision/eye_phenotype	1.13583107
74	MP0009703_decreased_birth_body	1.13563217
75	MP0002111_abnormal_tail_morphology	1.11231483
76	MP0002233_abnormal_nose_morphology	1.11199744
77	MP0002736_abnormal_nociception_after	1.10878703
78	MP0002009_preneoplasia	1.10620176
79	MP0001286_abnormal_eye_development	1.10275300
80	MP0003786_premature_aging	1.06342160
81	MP0002638_abnormal_pupillary_reflex	1.06239549
82	MP0004859_abnormal_synaptic_plasticity	1.06197704
83	MP0005171_absent_coat_pigmentation	1.04770754
84	MP0003718_maternal_effect	1.04061174
85	MP0009672_abnormal_birth_weight	1.03969887
86	MP0002932_abnormal_joint_morphology	1.03881806
87	MP0000432_abnormal_head_morphology	1.03351724
88	MP0009697_abnormal_copulation	1.02934913
89	MP0000955_abnormal_spinal_cord	1.02195599
90	MP0002116_abnormal_craniofacial_bone	1.01344452
91	MP0002152_abnormal_brain_morphology	1.00835168
92	MP0003705_abnormal_hypodermis_morpholog	1.00545847
93	MP0005499_abnormal_olfactory_system	1.00390959
94	MP0005394_taste/olfaction_phenotype	1.00390959
95	MP0002697_abnormal_eye_size	0.99081376
96	MP0002282_abnormal_trachea_morphology	0.98800513
97	MP0000647_abnormal_sebaceous_gland	0.98663750
98	MP0006292_abnormal_olfactory_placode	0.97274362
99	MP0002114_abnormal_axial_skeleton	0.96916266
100	MP0002751_abnormal_autonomic_nervous	0.96668510
101	MP0004808_abnormal_hematopoietic_stem	0.93079587
102	MP0001486_abnormal_startle_reflex	0.90776533
103	MP0000631_abnormal_neuroendocrine_gland	0.90193397
104	MP0002081_perinatal_lethality	0.90070064
105	MP0001346_abnormal_lacrimal_gland	0.89986706
106	MP0005187_abnormal_penis_morphology	0.89492914
107	MP0002557_abnormal_social/conspecific_i	0.89244680
108	MP0004811_abnormal_neuron_physiology	0.88890545
109	MP0006054_spinal_hemorrhage	0.88611540
110	MP0000778_abnormal_nervous_system	0.88598424
111	MP0005423_abnormal_somatic_nervous	0.87638891
112	MP0002752_abnormal_somatic_nervous	0.86384862
113	MP0002109_abnormal_limb_morphology	0.86284357
114	MP0002396_abnormal_hematopoietic_system	0.84719271
115	MP0002925_abnormal_cardiovascular_devel	0.83773373
116	MP0004133_heterotaxia	0.83326462
117	MP0002734_abnormal_mechanical_nocicepti	0.83271330
118	MP0009046_muscle_twitch	0.83152027
119	MP0002177_abnormal_outer_ear	0.82112278
120	MP0003635_abnormal_synaptic_transmissio	0.81621696
121	MP0002882_abnormal_neuron_morphology	0.80797097
122	MP0003943_abnormal_hepatobiliary_system	0.80330915
123	MP0002092_abnormal_eye_morphology	0.79887082
124	MP0002653_abnormal_ependyma_morphology	0.79392379
125	MP0003938_abnormal_ear_development	0.77943110
126	MP0000313_abnormal_cell_death	0.77003225
127	MP0001968_abnormal_touch/_nociception	0.76732874
128	MP0000733_abnormal_muscle_development	0.74761388
129	MP0005623_abnormal_meninges_morphology	0.74386117
130	MP0005503_abnormal_tendon_morphology	0.73795846
131	MP0002160_abnormal_reproductive_system	0.71661069
132	MP0000266_abnormal_heart_morphology	0.71377789
133	MP0002210_abnormal_sex_determination	0.71176663
134	MP0002127_abnormal_cardiovascular_syste	0.68078328

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	4.04489332
2	Short 4th metacarpal (HP:0010044)	4.04489332
3	Volvulus (HP:0002580)	3.45728874
4	Cortical dysplasia (HP:0002539)	3.45121977
5	Abnormality of the labia minora (HP:0012880)	3.00615671
6	Abnormality of the 4th metacarpal (HP:0010012)	2.97687444
7	Nephroblastoma (Wilms tumor) (HP:0002667)	2.92266356
8	Embryonal renal neoplasm (HP:0011794)	2.83801662
9	Colon cancer (HP:0003003)	2.82576007
10	Abnormal lung lobation (HP:0002101)	2.81605536
11	Renal duplication (HP:0000075)	2.73457539
12	Medulloblastoma (HP:0002885)	2.67738492
13	Increased nuchal translucency (HP:0010880)	2.67537742
14	Chromsome breakage (HP:0040012)	2.57475452
15	Deep philtrum (HP:0002002)	2.48153707
16	Hepatoblastoma (HP:0002884)	2.44356191
17	Patellar aplasia (HP:0006443)	2.43386801
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.39547550
19	Asymmetry of the thorax (HP:0001555)	2.38974132
20	Ectopic kidney (HP:0000086)	2.38941509
21	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.38245163
22	Aplasia/Hypoplasia of the patella (HP:0006498)	2.34307282
23	Astrocytoma (HP:0009592)	2.30368823
24	Abnormality of the astrocytes (HP:0100707)	2.30368823
25	Selective tooth agenesis (HP:0001592)	2.29554093
26	Aqueductal stenosis (HP:0002410)	2.25831583
27	Birth length less than 3rd percentile (HP:0003561)	2.24729523
28	Deviation of the thumb (HP:0009603)	2.21741214
29	Spinal cord lesions (HP:0100561)	2.19943902
30	Syringomyelia (HP:0003396)	2.19943902
31	Drooling (HP:0002307)	2.19004483
32	Oligodactyly (hands) (HP:0001180)	2.18820403
33	Septo-optic dysplasia (HP:0100842)	2.18375538
34	Vaginal atresia (HP:0000148)	2.17199912
35	Papillary thyroid carcinoma (HP:0002895)	2.16834949
36	Ependymoma (HP:0002888)	2.16442355
37	Genital tract atresia (HP:0001827)	2.16298423
38	Diastasis recti (HP:0001540)	2.16288440
39	Abnormal number of incisors (HP:0011064)	2.15159925
40	Abnormality of the preputium (HP:0100587)	2.10695107
41	Glioma (HP:0009733)	2.09972518
42	Abnormality of chromosome stability (HP:0003220)	2.08937753
43	Meckel diverticulum (HP:0002245)	2.05171633
44	Gait imbalance (HP:0002141)	2.04904564
45	Abnormality of chromosome segregation (HP:0002916)	2.04539665
46	Atresia of the external auditory canal (HP:0000413)	2.03447421
47	Broad thumb (HP:0011304)	2.03001040
48	Abnormality of the ileum (HP:0001549)	2.02987305
49	True hermaphroditism (HP:0010459)	2.02612235
50	Proximal placement of thumb (HP:0009623)	2.00767942
51	Pancreatic cysts (HP:0001737)	2.00207031
52	Congenital primary aphakia (HP:0007707)	1.99247066
53	Impulsivity (HP:0100710)	1.99156623
54	Abnormality of the anterior horn cell (HP:0006802)	1.98591947
55	Degeneration of anterior horn cells (HP:0002398)	1.98591947
56	Sloping forehead (HP:0000340)	1.97194598
57	Missing ribs (HP:0000921)	1.97044024
58	Rhabdomyosarcoma (HP:0002859)	1.95078589
59	Hypoplastic pelvis (HP:0008839)	1.94639116
60	Rib fusion (HP:0000902)	1.94243054
61	Oligodactyly (HP:0012165)	1.93594571
62	Medial flaring of the eyebrow (HP:0010747)	1.93263518
63	Preaxial hand polydactyly (HP:0001177)	1.92230427
64	Triphalangeal thumb (HP:0001199)	1.92151577
65	Small intestinal stenosis (HP:0012848)	1.91473821
66	Duodenal stenosis (HP:0100867)	1.91473821
67	Facial hemangioma (HP:0000329)	1.90934753
68	Midline defect of the nose (HP:0004122)	1.90638393
69	Broad phalanges of the hand (HP:0009768)	1.89471648
70	Excessive salivation (HP:0003781)	1.88978205
71	Supernumerary spleens (HP:0009799)	1.87830331
72	Nephronophthisis (HP:0000090)	1.86879652
73	Skull defect (HP:0001362)	1.86830270
74	Optic nerve hypoplasia (HP:0000609)	1.84710561
75	Nephrogenic diabetes insipidus (HP:0009806)	1.84520086
76	High anterior hairline (HP:0009890)	1.84224382
77	Pancreatic fibrosis (HP:0100732)	1.83637271
78	Lissencephaly (HP:0001339)	1.83404965
79	Bifid tongue (HP:0010297)	1.83347878
80	Gastrointestinal atresia (HP:0002589)	1.83235132
81	Microglossia (HP:0000171)	1.81941717
82	Anophthalmia (HP:0000528)	1.81608158
83	Poor coordination (HP:0002370)	1.81385144
84	Hypoplastic female external genitalia (HP:0012815)	1.81062591
85	Subacute progressive viral hepatitis (HP:0006572)	1.80712841
86	Short 5th finger (HP:0009237)	1.80383242
87	Tubulointerstitial nephritis (HP:0001970)	1.79822302
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79768538
89	Benign neoplasm of the central nervous system (HP:0100835)	1.79660722
90	Shawl scrotum (HP:0000049)	1.79471416
91	Micropenis (HP:0000054)	1.78936851
92	Renal hypoplasia (HP:0000089)	1.78913856
93	Broad finger (HP:0001500)	1.78891633
94	Short middle phalanx of the 5th finger (HP:0004220)	1.78534246
95	Labial hypoplasia (HP:0000066)	1.78112986
96	Mesomelia (HP:0003027)	1.77681384
97	11 pairs of ribs (HP:0000878)	1.76883943
98	Gastrointestinal carcinoma (HP:0002672)	1.76481411
99	Malignant gastrointestinal tract tumors (HP:0006749)	1.76481411
100	Absent eyebrow (HP:0002223)	1.75177709
101	Abnormality of the metopic suture (HP:0005556)	1.74705174
102	Abnormality of the incisor (HP:0000676)	1.74351658
103	Cutaneous finger syndactyly (HP:0010554)	1.72859191
104	Obsessive-compulsive behavior (HP:0000722)	1.71135445
105	Broad foot (HP:0001769)	1.71110915
106	Increased number of teeth (HP:0011069)	1.70912310
107	Abnormality of the nasal septum (HP:0000419)	1.70618456
108	Dandy-Walker malformation (HP:0001305)	1.70358915
109	Trigonocephaly (HP:0000243)	1.70251484
110	Intestinal fistula (HP:0100819)	1.69803322
111	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69412863
112	Cutaneous melanoma (HP:0012056)	1.69362314
113	Neoplasm of striated muscle (HP:0009728)	1.69269547
114	Esophageal atresia (HP:0002032)	1.68808920
115	Rectovaginal fistula (HP:0000143)	1.68669249
116	Rectal fistula (HP:0100590)	1.68669249
117	Astigmatism (HP:0000483)	1.67424383
118	Neoplasm of the oral cavity (HP:0100649)	1.66934881
119	Absent radius (HP:0003974)	1.66509297
120	Postaxial hand polydactyly (HP:0001162)	1.66405325
121	Intestinal polyposis (HP:0200008)	1.66209469
122	Hyperglycinemia (HP:0002154)	1.65736729
123	Bicornuate uterus (HP:0000813)	1.65673969
124	Long eyelashes (HP:0000527)	1.65456060
125	Intestinal atresia (HP:0011100)	1.65335121
126	Abnormality of the septum pellucidum (HP:0007375)	1.65049650
127	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.64799406
128	Long clavicles (HP:0000890)	1.64692242
129	Embryonal neoplasm (HP:0002898)	1.64531690
130	Broad palm (HP:0001169)	1.64070693
131	Abnormality of the duodenum (HP:0002246)	1.63646192
132	Abnormality of the carotid arteries (HP:0005344)	1.63030417
133	Ovarian neoplasm (HP:0100615)	1.62977120
134	Broad phalanx (HP:0006009)	1.62940395
135	Cafe-au-lait spot (HP:0000957)	1.62579842
136	Abnormality of the parathyroid morphology (HP:0011766)	1.62495214
137	Bilateral microphthalmos (HP:0007633)	1.62120567
138	Neoplasm of the adrenal cortex (HP:0100641)	1.62097228
139	Molar tooth sign on MRI (HP:0002419)	1.62084755
140	Abnormality of midbrain morphology (HP:0002418)	1.62084755
141	Intestinal polyp (HP:0005266)	1.60556512
142	Uterine neoplasm (HP:0010784)	1.60273620
143	Renovascular hypertension (HP:0100817)	1.60271543
144	Hemivertebrae (HP:0002937)	1.60230701
145	Morphological abnormality of the middle ear (HP:0008609)	1.59773487
146	Specific learning disability (HP:0001328)	1.59660671
147	Cupped ear (HP:0000378)	1.57240602
148	Absent septum pellucidum (HP:0001331)	1.56900525
149	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.56565344
150	Absent forearm bone (HP:0003953)	1.56514588
151	Aplasia involving forearm bones (HP:0009822)	1.56514588
152	Abdominal situs inversus (HP:0003363)	1.55424953
153	Abnormality of abdominal situs (HP:0011620)	1.55424953
154	Anencephaly (HP:0002323)	1.52330390
155	Hyperventilation (HP:0002883)	1.51992158
156	Pendular nystagmus (HP:0012043)	1.51991968

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.55209269
2	WNK3	3.18006682
3	MKNK1	3.16581891
4	SRPK1	2.88732416
5	NEK1	2.64724016
6	WEE1	2.42796082
7	PLK3	2.42557259
8	TRIM28	2.39403864
9	BRSK2	2.33901992
10	ERBB3	2.32513755
11	ZAK	2.26176087
12	MKNK2	2.17519394
13	TSSK6	2.15064157
14	PASK	2.12834190
15	TNIK	2.11970861
16	AKT3	2.08445649
17	NEK2	2.04184652
18	BUB1	2.02613645
19	BRSK1	1.90917594
20	TTK	1.84121240
21	ATR	1.81676535
22	PLK1	1.80992216
23	CDK12	1.73387200
24	MAP4K2	1.66624921
25	TAF1	1.66159604
26	PLK4	1.64515514
27	EIF2AK1	1.61931331
28	PNCK	1.54549997
29	MAP2K7	1.54280672
30	CHEK2	1.53057331
31	PLK2	1.47189724
32	LATS1	1.45642410
33	DYRK2	1.45221612
34	CCNB1	1.44909645
35	ACVR1B	1.41518039
36	BMPR1B	1.37244805
37	EPHA4	1.34716939
38	VRK2	1.33553144
39	FGFR2	1.31115786
40	STK38L	1.30932494
41	CHEK1	1.30041499
42	* AURKB	1.26722787
43	VRK1	1.24774128
44	CSNK1G1	1.24715459
45	TGFBR1	1.23070004
46	ATM	1.17913620
47	BRD4	1.17824900
48	YES1	1.17702024
49	SGK2	1.15775275
50	CSNK1G2	1.15416183
51	CSNK1A1L	1.13842386
52	CSNK1G3	1.12359574
53	STK3	1.12114888
54	CDK7	1.10642733
55	KSR1	1.01068459
56	CASK	0.99146634
57	CDK2	0.98706744
58	PBK	0.97280813
59	CDK8	0.97274276
60	CDK6	0.97189683
61	FGFR1	0.95311022
62	MELK	0.93867666
63	CDK1	0.93128573
64	NTRK2	0.92699298
65	STK4	0.92070069
66	STK24	0.90740931
67	RPS6KB1	0.87262872
68	SCYL2	0.86672436
69	DYRK3	0.84950898
70	AURKA	0.84105988
71	RPS6KB2	0.82252436
72	CDK4	0.82017017
73	PDGFRA	0.80647100
74	BCR	0.79363165
75	UHMK1	0.78973281
76	CLK1	0.77749887
77	SGK3	0.76758878
78	EIF2AK2	0.75763137
79	OBSCN	0.73600778
80	MAPK13	0.72594844
81	LATS2	0.69727771
82	CDK3	0.65779963
83	PKN2	0.65759746
84	SIK3	0.65313451
85	MAP3K8	0.65245538
86	EPHB2	0.63171631
87	ALK	0.61740060
88	PAK3	0.61372557
89	RPS6KC1	0.61295999
90	RPS6KL1	0.61295999
91	MAP3K10	0.59875048
92	PRKCG	0.59137894
93	MARK1	0.59070600
94	PRKDC	0.58540100
95	DAPK1	0.57476941
96	CAMK1G	0.57154040
97	TLK1	0.55618669
98	MAPK14	0.55194531
99	PAK4	0.55171463
100	MINK1	0.54799750
101	DYRK1A	0.52966104
102	PRKD3	0.52538120
103	DDR2	0.52398255
104	FRK	0.52294035
105	CDK18	0.52103048
106	RPS6KA6	0.48958313
107	CSNK1D	0.47053931
108	RPS6KA4	0.46625073
109	MTOR	0.46547028
110	INSRR	0.46442624
111	EEF2K	0.44559936
112	AKT1	0.44223254
113	CDK15	0.44086306
114	PRKCE	0.43800335
115	EIF2AK3	0.43371051
116	GSK3B	0.42699364
117	* CSNK2A1	0.42548112
118	PAK6	0.40997150
119	CDK11A	0.40600317
120	NUAK1	0.40523045
121	CSNK2A2	0.40358057
122	NEK9	0.40062497
123	SGK494	0.39988293
124	SGK223	0.39988293
125	STK39	0.38864460
126	CDK14	0.38299879
127	MAP3K4	0.38281383
128	PKN1	0.36159786
129	CSNK1E	0.35288778
130	RPS6KA2	0.35265044
131	MAP2K4	0.34619044
132	FLT3	0.31415356
133	EPHA3	0.31088544
134	NLK	0.29755454
135	OXSR1	0.29646131

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.16795855
2	Mismatch repair_Homo sapiens_hsa03430	4.02166341
3	Cell cycle_Homo sapiens_hsa04110	3.33482690
4	Base excision repair_Homo sapiens_hsa03410	2.94089891
5	RNA transport_Homo sapiens_hsa03013	2.87548634
6	Spliceosome_Homo sapiens_hsa03040	2.83884514
7	Homologous recombination_Homo sapiens_hsa03440	2.76312501
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.57771882
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51010150
10	mRNA surveillance pathway_Homo sapiens_hsa03015	2.49679127
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.46557441
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38085615
13	One carbon pool by folate_Homo sapiens_hsa00670	2.13268968
14	Non-homologous end-joining_Homo sapiens_hsa03450	2.12327633
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.08664980
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.08417374
17	Protein export_Homo sapiens_hsa03060	2.03820539
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.99460217
19	RNA degradation_Homo sapiens_hsa03018	1.91903426
20	Oocyte meiosis_Homo sapiens_hsa04114	1.81906903
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.75203929
22	Propanoate metabolism_Homo sapiens_hsa00640	1.73716286
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.69498477
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.61586477
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.60682511
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.51668493
27	Basal transcription factors_Homo sapiens_hsa03022	1.42358113
28	MicroRNAs in cancer_Homo sapiens_hsa05206	1.41867914
29	Butanoate metabolism_Homo sapiens_hsa00650	1.38742725
30	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36900593
31	p53 signaling pathway_Homo sapiens_hsa04115	1.36291527
32	RNA polymerase_Homo sapiens_hsa03020	1.34084843
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.34057838
34	Alcoholism_Homo sapiens_hsa05034	1.31961432
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27945068
36	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.27535207
37	Colorectal cancer_Homo sapiens_hsa05210	1.26544247
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20992293
39	Adherens junction_Homo sapiens_hsa04520	1.20452867
40	Endometrial cancer_Homo sapiens_hsa05213	1.18721997
41	Thyroid cancer_Homo sapiens_hsa05216	1.18051515
42	Viral carcinogenesis_Homo sapiens_hsa05203	1.17973566
43	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.17077350
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16038803
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11286356
46	Wnt signaling pathway_Homo sapiens_hsa04310	1.09342377
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07510672
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07299871
49	HTLV-I infection_Homo sapiens_hsa05166	1.06438113
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.01054922
51	Phototransduction_Homo sapiens_hsa04744	0.99010819
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98446581
53	Proteasome_Homo sapiens_hsa03050	0.96833493
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93599444
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.90474339
56	Fatty acid elongation_Homo sapiens_hsa00062	0.89551474
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.89348062
58	GABAergic synapse_Homo sapiens_hsa04727	0.85938634
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.85292736
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.85260723
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.84865268
62	Tight junction_Homo sapiens_hsa04530	0.83878122
63	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.83738472
64	Taste transduction_Homo sapiens_hsa04742	0.82600556
65	Small cell lung cancer_Homo sapiens_hsa05222	0.80518686
66	mTOR signaling pathway_Homo sapiens_hsa04150	0.80387361
67	Melanoma_Homo sapiens_hsa05218	0.79443010
68	Non-small cell lung cancer_Homo sapiens_hsa05223	0.78400640
69	Prostate cancer_Homo sapiens_hsa05215	0.77939008
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.76515484
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.75446037
72	Purine metabolism_Homo sapiens_hsa00230	0.75090054
73	Melanogenesis_Homo sapiens_hsa04916	0.73741613
74	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73199161
75	Proteoglycans in cancer_Homo sapiens_hsa05205	0.72078536
76	Glioma_Homo sapiens_hsa05214	0.70522428
77	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.70032316
78	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.68945287
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68544648
80	Axon guidance_Homo sapiens_hsa04360	0.68332727
81	Notch signaling pathway_Homo sapiens_hsa04330	0.67533236
82	Pathways in cancer_Homo sapiens_hsa05200	0.67207965
83	Viral myocarditis_Homo sapiens_hsa05416	0.67002611
84	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.62141159
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.61613332
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60361778
87	Carbon metabolism_Homo sapiens_hsa01200	0.60260627
88	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.59776506
89	Bladder cancer_Homo sapiens_hsa05219	0.58889524
90	Cocaine addiction_Homo sapiens_hsa05030	0.58515396
91	Long-term potentiation_Homo sapiens_hsa04720	0.58425359
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.58343160
93	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57979780
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57139446
95	Lysine degradation_Homo sapiens_hsa00310	0.54040386
96	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53751842
97	Focal adhesion_Homo sapiens_hsa04510	0.53380454
98	Huntingtons disease_Homo sapiens_hsa05016	0.52381950
99	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.52237580
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.51639602
101	Herpes simplex infection_Homo sapiens_hsa05168	0.50485773
102	Morphine addiction_Homo sapiens_hsa05032	0.50381480
103	Gap junction_Homo sapiens_hsa04540	0.48930794
104	ErbB signaling pathway_Homo sapiens_hsa04012	0.48466492
105	Pancreatic cancer_Homo sapiens_hsa05212	0.47524413
106	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47131787
107	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46624530
108	FoxO signaling pathway_Homo sapiens_hsa04068	0.45861839
109	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45339290
110	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.44063107
111	Circadian rhythm_Homo sapiens_hsa04710	0.42858987
112	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.42124813
113	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.41728925
114	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40334492
115	Dopaminergic synapse_Homo sapiens_hsa04728	0.39936427
116	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.38269342
117	Hepatitis B_Homo sapiens_hsa05161	0.38043464
118	Parkinsons disease_Homo sapiens_hsa05012	0.36431356
119	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34478021
120	Nicotine addiction_Homo sapiens_hsa05033	0.34212345
121	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.33776376
122	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.33549548
123	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.32966527
124	Amphetamine addiction_Homo sapiens_hsa05031	0.32867550
125	Rap1 signaling pathway_Homo sapiens_hsa04015	0.31920279
126	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31223112
127	Estrogen signaling pathway_Homo sapiens_hsa04915	0.30512971
128	Long-term depression_Homo sapiens_hsa04730	0.29993988
129	Folate biosynthesis_Homo sapiens_hsa00790	0.29990657
130	Insulin secretion_Homo sapiens_hsa04911	0.29099024
131	Glucagon signaling pathway_Homo sapiens_hsa04922	0.28806994
132	Metabolic pathways_Homo sapiens_hsa01100	0.28794382
133	Insulin signaling pathway_Homo sapiens_hsa04910	0.28778789
134	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.27527648
135	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27452520
136	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.27303945
137	Serotonergic synapse_Homo sapiens_hsa04726	0.27159449
138	Tryptophan metabolism_Homo sapiens_hsa00380	0.26273039
139	Ether lipid metabolism_Homo sapiens_hsa00565	0.26130671
140	MAPK signaling pathway_Homo sapiens_hsa04010	0.25183618
141	Selenocompound metabolism_Homo sapiens_hsa00450	0.24774970
142	Renal cell carcinoma_Homo sapiens_hsa05211	0.21627076
143	Circadian entrainment_Homo sapiens_hsa04713	0.21332879
144	Olfactory transduction_Homo sapiens_hsa04740	0.21296482

CBX5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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