CBX5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.64848140
2positive regulation of mitochondrial fission (GO:0090141)4.21598990
3centriole replication (GO:0007099)4.14345577
4metaphase plate congression (GO:0051310)3.91767953
5negative regulation of transcription regulatory region DNA binding (GO:2000678)3.89779075
6regulation of centriole replication (GO:0046599)3.87454561
7lactate metabolic process (GO:0006089)3.84736077
8sister chromatid segregation (GO:0000819)3.79218354
9histone mRNA metabolic process (GO:0008334)3.73614772
10mitotic sister chromatid segregation (GO:0000070)3.73283725
11mitotic metaphase plate congression (GO:0007080)3.65506516
12retinal cone cell development (GO:0046549)3.65428138
13histone mRNA catabolic process (GO:0071044)3.65202202
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63004396
15kinetochore organization (GO:0051383)3.61259541
16DNA topological change (GO:0006265)3.55966720
17neural tube formation (GO:0001841)3.50588377
18intraciliary transport (GO:0042073)3.49467895
19negative regulation of DNA recombination (GO:0045910)3.48110079
20regulation of sulfur metabolic process (GO:0042762)3.44575842
21nuclear pore complex assembly (GO:0051292)3.44233835
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42904285
23regulation of mitotic spindle checkpoint (GO:1903504)3.42904285
24DNA integration (GO:0015074)3.41664333
25CENP-A containing nucleosome assembly (GO:0034080)3.41448368
26chromatin remodeling at centromere (GO:0031055)3.40486698
27postreplication repair (GO:0006301)3.40283377
28replication fork processing (GO:0031297)3.38850772
29kinetochore assembly (GO:0051382)3.36754899
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.36218169
31attachment of spindle microtubules to kinetochore (GO:0008608)3.27236181
32peptidyl-lysine trimethylation (GO:0018023)3.26390680
33muscle organ morphogenesis (GO:0048644)3.24138695
34regulation of acyl-CoA biosynthetic process (GO:0050812)3.21586838
35microtubule polymerization or depolymerization (GO:0031109)3.21131862
36epithelial cilium movement (GO:0003351)3.20934202
37microtubule depolymerization (GO:0007019)3.20028552
38mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.14672404
39positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.14672404
40anterograde synaptic vesicle transport (GO:0048490)3.13946987
41recombinational repair (GO:0000725)3.12552565
42double-strand break repair via homologous recombination (GO:0000724)3.12397403
43spindle checkpoint (GO:0031577)3.12195353
44nuclear pore organization (GO:0006999)3.12104975
45platelet dense granule organization (GO:0060155)3.11376591
46microtubule anchoring (GO:0034453)3.07325839
47histone exchange (GO:0043486)3.04583823
48limb bud formation (GO:0060174)3.04405913
49resolution of meiotic recombination intermediates (GO:0000712)3.03724812
50mitotic spindle checkpoint (GO:0071174)3.02884348
51respiratory chain complex IV assembly (GO:0008535)3.00261430
52fibroblast migration (GO:0010761)2.94222351
53translesion synthesis (GO:0019985)2.94085344
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93520160
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93520160
56mitotic sister chromatid cohesion (GO:0007064)2.92860322
57nucleotide-excision repair, DNA gap filling (GO:0006297)2.90057079
58negative regulation of translation, ncRNA-mediated (GO:0040033)2.89324290
59regulation of translation, ncRNA-mediated (GO:0045974)2.89324290
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89324290
61establishment of chromosome localization (GO:0051303)2.88800378
62regulation of mitochondrial fission (GO:0090140)2.88754285
63protein localization to kinetochore (GO:0034501)2.88189064
64cornea development in camera-type eye (GO:0061303)2.87630538
65DNA strand renaturation (GO:0000733)2.86047839
66regulation of coenzyme metabolic process (GO:0051196)2.85834341
67regulation of cofactor metabolic process (GO:0051193)2.85834341
68axoneme assembly (GO:0035082)2.85655752
69mRNA cleavage (GO:0006379)2.83848371
70regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.83170558
71olfactory bulb development (GO:0021772)2.81688806
72female gonad development (GO:0008585)2.81628693
73NLS-bearing protein import into nucleus (GO:0006607)2.80415630
74mitotic G2/M transition checkpoint (GO:0044818)2.76908824
75histone H3-K9 methylation (GO:0051567)2.73932529
76establishment of protein localization to Golgi (GO:0072600)2.73851949
77protein K11-linked deubiquitination (GO:0035871)2.72036358
78cytochrome complex assembly (GO:0017004)2.70544152
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.70096892
80pore complex assembly (GO:0046931)2.69825070
81centrosome organization (GO:0051297)2.68937449
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68441284
83double-strand break repair via nonhomologous end joining (GO:0006303)2.68272891
84non-recombinational repair (GO:0000726)2.68272891
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.68120469
86negative regulation of sister chromatid segregation (GO:0033046)2.68120469
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68120469
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68120469
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68120469
90N-terminal protein amino acid acetylation (GO:0006474)2.67807022
91glucocorticoid receptor signaling pathway (GO:0042921)2.67685589
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67461055
93regulation of centrosome duplication (GO:0010824)2.66847481
94DNA replication checkpoint (GO:0000076)2.66135717
95nonmotile primary cilium assembly (GO:0035058)2.65273588
96mitotic spindle assembly checkpoint (GO:0007094)2.63757555
97regulation of Rac protein signal transduction (GO:0035020)2.62046004
98arginine catabolic process (GO:0006527)2.61503413
99monoubiquitinated protein deubiquitination (GO:0035520)2.61428533
100chromosome segregation (GO:0007059)2.60046236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.71483079
2E2F7_22180533_ChIP-Seq_HELA_Human3.49435869
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18145494
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.01202703
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89795681
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70520485
7ZNF274_21170338_ChIP-Seq_K562_Hela2.61241140
8IGF1R_20145208_ChIP-Seq_DFB_Human2.59002648
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58188215
10ELK1_19687146_ChIP-ChIP_HELA_Human2.51137227
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44085670
12VDR_22108803_ChIP-Seq_LS180_Human2.39810886
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.34430876
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21138402
15EWS_26573619_Chip-Seq_HEK293_Human2.16335038
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.09557718
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07572794
18FUS_26573619_Chip-Seq_HEK293_Human2.02403587
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93703260
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86707691
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.85236442
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84755474
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.77193966
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74682213
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72614464
26TAF15_26573619_Chip-Seq_HEK293_Human1.69761119
27P300_19829295_ChIP-Seq_ESCs_Human1.69666273
28ER_23166858_ChIP-Seq_MCF-7_Human1.68688636
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67845793
30GBX2_23144817_ChIP-Seq_PC3_Human1.58070967
31VDR_23849224_ChIP-Seq_CD4+_Human1.56770526
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53035691
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.52947836
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52177092
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.51674825
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50650701
37SMAD4_21799915_ChIP-Seq_A2780_Human1.46027863
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45181649
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45128267
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44005036
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43539346
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40507467
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36831835
44TP53_18474530_ChIP-ChIP_U2OS_Human1.36816482
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36197807
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35517789
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35185065
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35169458
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34357230
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.33898921
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.33379638
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33162924
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.32685185
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31351972
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28926302
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27353682
57CBP_20019798_ChIP-Seq_JUKART_Human1.27353682
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27002354
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26312010
60STAT3_23295773_ChIP-Seq_U87_Human1.26280178
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26202045
62P53_22387025_ChIP-Seq_ESCs_Mouse1.26140014
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22683064
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.19878818
65TCF4_22108803_ChIP-Seq_LS180_Human1.19446258
66FOXP3_21729870_ChIP-Seq_TREG_Human1.19199100
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19029949
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19027949
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18201115
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17530837
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.16903673
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.15192287
73P300_18555785_Chip-Seq_ESCs_Mouse1.14375567
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13459666
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13066127
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12218155
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.11595317
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11208545
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10903904
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.10345087
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09765582
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08731148
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.08241036
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07684352
85CDX2_22108803_ChIP-Seq_LS180_Human1.07214898
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.07123035
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05921915
88TCF4_23295773_ChIP-Seq_U87_Human1.05776344
89NANOG_19829295_ChIP-Seq_ESCs_Human1.05569913
90SOX2_19829295_ChIP-Seq_ESCs_Human1.05569913
91ETV1_20927104_ChIP-Seq_GIST48_Human1.05337767
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03378823
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.03324924
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.02946887
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.02905959
96BCAT_22108803_ChIP-Seq_LS180_Human1.02822702
97TP53_22573176_ChIP-Seq_HFKS_Human1.02244034
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02197994
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01937291
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01215158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.83895431
2MP0008057_abnormal_DNA_replication3.67775555
3MP0003941_abnormal_skin_development3.28997873
4MP0003195_calcinosis3.21358138
5MP0008058_abnormal_DNA_repair3.05847542
6MP0006072_abnormal_retinal_apoptosis2.63953421
7MP0003880_abnormal_central_pattern2.49949700
8MP0002638_abnormal_pupillary_reflex2.44503303
9MP0000372_irregular_coat_pigmentation2.43493503
10MP0006292_abnormal_olfactory_placode2.32109805
11MP0002938_white_spotting2.31945396
12MP0000647_abnormal_sebaceous_gland2.29510525
13MP0003787_abnormal_imprinting2.18848802
14MP0008877_abnormal_DNA_methylation2.12181795
15MP0008995_early_reproductive_senescence2.11981014
16MP0010094_abnormal_chromosome_stability2.11284645
17MP0002009_preneoplasia1.98877152
18MP0003950_abnormal_plasma_membrane1.92567017
19MP0005253_abnormal_eye_physiology1.85331394
20MP0000427_abnormal_hair_cycle1.83928280
21MP0002102_abnormal_ear_morphology1.80674738
22MP0005551_abnormal_eye_electrophysiolog1.78540811
23MP0003121_genomic_imprinting1.75259874
24MP0003077_abnormal_cell_cycle1.74201990
25MP0002090_abnormal_vision1.71048025
26MP0005248_abnormal_Harderian_gland1.68702123
27MP0003890_abnormal_embryonic-extraembry1.68091693
28MP0003786_premature_aging1.67622651
29MP0009697_abnormal_copulation1.64714548
30MP0006082_CNS_inflammation1.62832073
31MP0000516_abnormal_urinary_system1.59973529
32MP0005367_renal/urinary_system_phenotyp1.59973529
33MP0001529_abnormal_vocalization1.53641182
34MP0005187_abnormal_penis_morphology1.53624357
35MP0003111_abnormal_nucleus_morphology1.44252513
36MP0000383_abnormal_hair_follicle1.39051815
37MP0003567_abnormal_fetal_cardiomyocyte1.39016344
38MP0003656_abnormal_erythrocyte_physiolo1.37745359
39MP0002234_abnormal_pharynx_morphology1.33000005
40MP0001293_anophthalmia1.32306458
41MP0003693_abnormal_embryo_hatching1.31543912
42MP0001764_abnormal_homeostasis1.31381303
43MP0010678_abnormal_skin_adnexa1.25085386
44MP0005075_abnormal_melanosome_morpholog1.23790121
45MP0002751_abnormal_autonomic_nervous1.21632804
46MP0008875_abnormal_xenobiotic_pharmacok1.21105245
47MP0001545_abnormal_hematopoietic_system1.14954220
48MP0005397_hematopoietic_system_phenotyp1.14954220
49MP0003252_abnormal_bile_duct1.12744545
50MP0008872_abnormal_physiological_respon1.10948517
51MP0005266_abnormal_metabolism1.10668733
52MP0002876_abnormal_thyroid_physiology1.09774324
53MP0006054_spinal_hemorrhage1.08960271
54MP0001346_abnormal_lacrimal_gland1.07884483
55MP0003718_maternal_effect1.05496087
56MP0008007_abnormal_cellular_replicative1.05344389
57MP0009046_muscle_twitch1.05084517
58MP0008961_abnormal_basal_metabolism1.04744742
59MP0004381_abnormal_hair_follicle1.04295798
60MP0005391_vision/eye_phenotype1.02661529
61MP0002095_abnormal_skin_pigmentation1.01995992
62MP0001188_hyperpigmentation1.01974905
63MP0001986_abnormal_taste_sensitivity1.00989064
64MP0005174_abnormal_tail_pigmentation1.00911407
65MP0000778_abnormal_nervous_system0.99667847
66MP0001929_abnormal_gametogenesis0.99610821
67MP0005084_abnormal_gallbladder_morpholo0.98186338
68MP0003755_abnormal_palate_morphology0.98040398
69MP0010307_abnormal_tumor_latency0.96700217
70MP0001286_abnormal_eye_development0.94801317
71MP0008932_abnormal_embryonic_tissue0.90915255
72MP0003122_maternal_imprinting0.90751458
73MP0001119_abnormal_female_reproductive0.89900362
74MP0004957_abnormal_blastocyst_morpholog0.88263072
75MP0001502_abnormal_circadian_rhythm0.85489284
76MP0005195_abnormal_posterior_eye0.83933260
77MP0000653_abnormal_sex_gland0.83538510
78MP0006276_abnormal_autonomic_nervous0.82269993
79MP0003937_abnormal_limbs/digits/tail_de0.81587765
80MP0003698_abnormal_male_reproductive0.80037977
81MP0004142_abnormal_muscle_tone0.79549271
82MP0001501_abnormal_sleep_pattern0.79094284
83MP0005410_abnormal_fertilization0.76626849
84MP0002928_abnormal_bile_duct0.75343770
85MP0002210_abnormal_sex_determination0.75042298
86MP0003646_muscle_fatigue0.74549312
87MP0001324_abnormal_eye_pigmentation0.73994384
88MP0004133_heterotaxia0.73082291
89MP0002233_abnormal_nose_morphology0.72663221
90MP0005389_reproductive_system_phenotype0.72136766
91MP0003221_abnormal_cardiomyocyte_apopto0.72013697
92MP0005646_abnormal_pituitary_gland0.70874916
93MP0001145_abnormal_male_reproductive0.70686928
94MP0005395_other_phenotype0.68566701
95MP0008789_abnormal_olfactory_epithelium0.68525386
96MP0003938_abnormal_ear_development0.67797320
97MP0010386_abnormal_urinary_bladder0.67560836
98MP0002160_abnormal_reproductive_system0.66740561
99MP0002752_abnormal_somatic_nervous0.66317187
100MP0009703_decreased_birth_body0.66185323

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of chromosome stability (HP:0003220)3.41600970
2Intestinal atresia (HP:0011100)3.04326639
3Aplasia/Hypoplasia of the uvula (HP:0010293)2.99485199
4Long clavicles (HP:0000890)2.93668311
5Pancreatic cysts (HP:0001737)2.76781394
6Lipid accumulation in hepatocytes (HP:0006561)2.67434596
7Posterior subcapsular cataract (HP:0007787)2.67070316
8Acanthocytosis (HP:0001927)2.61703933
9Pancreatic fibrosis (HP:0100732)2.58189190
10Aplasia/Hypoplasia of the tibia (HP:0005772)2.55824307
11Molar tooth sign on MRI (HP:0002419)2.54406910
12Abnormality of midbrain morphology (HP:0002418)2.54406910
13Meckel diverticulum (HP:0002245)2.52105649
14Abnormality of the ileum (HP:0001549)2.43383026
15Ependymoma (HP:0002888)2.39210254
16Median cleft lip (HP:0000161)2.36866954
17Hypoplastic iliac wings (HP:0002866)2.34843015
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34689774
19Abnormal protein N-linked glycosylation (HP:0012347)2.34689774
20Abnormal protein glycosylation (HP:0012346)2.34689774
21Abnormal glycosylation (HP:0012345)2.34689774
22Hypobetalipoproteinemia (HP:0003563)2.29407237
23Abnormality of the duodenum (HP:0002246)2.29209719
24Increased hepatocellular lipid droplets (HP:0006565)2.29181641
25Sloping forehead (HP:0000340)2.28147724
26Chromsome breakage (HP:0040012)2.26627326
27Facial hemangioma (HP:0000329)2.22124928
28Abnormality of the labia minora (HP:0012880)2.21503280
29Type II lissencephaly (HP:0007260)2.19108391
30Medial flaring of the eyebrow (HP:0010747)2.17587250
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16796950
32Abnormality of the preputium (HP:0100587)2.15636555
33Duodenal stenosis (HP:0100867)2.15385856
34Small intestinal stenosis (HP:0012848)2.15385856
35Chronic hepatic failure (HP:0100626)2.15328735
36Genital tract atresia (HP:0001827)2.14589276
37Short tibia (HP:0005736)2.11613207
38True hermaphroditism (HP:0010459)2.10084359
39Cerebellar dysplasia (HP:0007033)2.09989924
40Volvulus (HP:0002580)2.09298299
41Acute necrotizing encephalopathy (HP:0006965)2.08365478
42Tubulointerstitial nephritis (HP:0001970)2.07556084
43Metaphyseal dysplasia (HP:0100255)2.06556352
44Congenital primary aphakia (HP:0007707)2.04338244
45Gastrointestinal atresia (HP:0002589)2.03827762
46Abnormality of macular pigmentation (HP:0008002)2.03505868
47Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03472310
48Febrile seizures (HP:0002373)2.03093311
49Medulloblastoma (HP:0002885)2.02775599
50Decreased lacrimation (HP:0000633)2.02008891
51Short middle phalanx of the 5th finger (HP:0004220)1.99335158
52Glioma (HP:0009733)1.97988584
53Pancreatic islet-cell hyperplasia (HP:0004510)1.97637258
54Rib fusion (HP:0000902)1.95302004
55Abnormality of the pons (HP:0007361)1.94998155
56Progressive macrocephaly (HP:0004481)1.94738497
57Hypoplasia of the pons (HP:0012110)1.94269922
58Hypoplastic pelvis (HP:0008839)1.93451130
59Hypoplastic labia majora (HP:0000059)1.93389415
60Supernumerary spleens (HP:0009799)1.92114003
61Bifid tongue (HP:0010297)1.92047709
62Gait imbalance (HP:0002141)1.90880496
63Astrocytoma (HP:0009592)1.90771014
64Abnormality of the astrocytes (HP:0100707)1.90771014
65Clubbing of toes (HP:0100760)1.90538571
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.89126477
67Preaxial hand polydactyly (HP:0001177)1.88041973
68Pendular nystagmus (HP:0012043)1.87251988
69Fair hair (HP:0002286)1.83994341
70Astigmatism (HP:0000483)1.83922731
71Abnormal mitochondria in muscle tissue (HP:0008316)1.83754401
72Nephrogenic diabetes insipidus (HP:0009806)1.83676300
73Dyskinesia (HP:0100660)1.82547562
74Dandy-Walker malformation (HP:0001305)1.82436834
75Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82085100
76Postaxial foot polydactyly (HP:0001830)1.81165612
77Acute encephalopathy (HP:0006846)1.80843767
78Submucous cleft hard palate (HP:0000176)1.80805012
79Mitochondrial inheritance (HP:0001427)1.80432798
80Cupped ear (HP:0000378)1.79537781
81Abnormality of the labia majora (HP:0012881)1.79368112
82Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77044327
83Vaginal atresia (HP:0000148)1.75966518
84Increased CSF lactate (HP:0002490)1.75893381
85Ectopic kidney (HP:0000086)1.75146264
86Capillary hemangiomas (HP:0005306)1.74319567
87Small hand (HP:0200055)1.74305123
88Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73964541
89Deep philtrum (HP:0002002)1.73945621
90Nephronophthisis (HP:0000090)1.72706056
91Hyperkalemia (HP:0002153)1.72339830
92Protruding tongue (HP:0010808)1.70285208
93Myelodysplasia (HP:0002863)1.69914992
94Birth length less than 3rd percentile (HP:0003561)1.69840070
95Poor coordination (HP:0002370)1.69612218
96Narrow forehead (HP:0000341)1.69576994
97Overfolded helix (HP:0000396)1.68837787
98Oligodactyly (hands) (HP:0001180)1.67178513
99Abnormal biliary tract morphology (HP:0012440)1.66646403
100Postaxial hand polydactyly (HP:0001162)1.66460325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.99779586
2FRK2.97354781
3TRIM282.91306690
4PLK22.77942655
5TNIK2.58801780
6PLK42.51620066
7SRPK12.43062686
8EIF2AK32.38497452
9BRD42.31897661
10WNK32.28010170
11BRSK22.26862794
12BCR2.21326798
13MKNK22.19008050
14EIF2AK12.16029710
15BMPR1B2.06662585
16CASK2.01521322
17PRKD31.98543582
18ZAK1.97391544
19MKNK11.93383861
20ERBB31.77367189
21AKT31.62765079
22NUAK11.61471570
23PAK31.55609542
24PLK31.53694469
25MAPK131.53007045
26PINK11.52285496
27PBK1.49879162
28BUB11.49564311
29WEE11.47420149
30TAOK31.40497463
31CDC71.37936779
32CLK11.36778457
33STK38L1.30473576
34MST41.26989886
35TTK1.14370511
36NEK11.12219263
37STK31.11967609
38ACVR1B1.09932367
39PIM21.07625397
40EPHA31.06840516
41EPHA41.05884281
42FLT31.05806952
43PDK21.04256038
44VRK10.92926007
45SIK30.92366823
46LATS10.87389210
47CAMK1D0.86052239
48GRK10.83750559
49ATR0.76908350
50PIK3CA0.75573744
51ATM0.71747428
52PLK10.69702235
53MARK30.68620262
54DYRK30.68094879
55STK40.67594438
56MAP3K40.66663422
57CSNK1A1L0.65743860
58BMPR20.64568796
59CHEK20.64446276
60PRKCE0.63048254
61CAMK1G0.62391347
62CSNK1G10.57324300
63MAP3K50.56433217
64EIF2AK20.56231655
65BRSK10.55473692
66STK160.54235508
67CSNK1G30.52653108
68PIM10.52117745
69SGK20.51574918
70DYRK1B0.50413260
71RPS6KA40.49512246
72NEK20.49459836
73CSNK1G20.48306941
74AURKB0.46916892
75ADRBK20.44760505
76CSNK1D0.43459377
77STK390.41833036
78CHEK10.41547173
79NLK0.39035646
80KSR10.37316862
81CDK60.36444113
82YES10.34760769
83MAP2K70.34124734
84UHMK10.33613603
85OXSR10.33520659
86STK100.33353555
87TEC0.33280863
88FGFR10.33085094
89FER0.31790421
90PKN20.28645625
91ERBB20.28016282
92BRAF0.27016661
93PIK3CG0.24616199
94CAMK40.24568866
95SGK10.22640557
96MAP3K70.22579040
97CDK10.22501410
98ABL10.22034206
99CSNK1A10.21657933
100PRKDC0.21511194

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.89372206
2Fanconi anemia pathway_Homo sapiens_hsa034603.24080527
3Non-homologous end-joining_Homo sapiens_hsa034503.01273554
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95034269
5Homologous recombination_Homo sapiens_hsa034402.92665869
6Basal transcription factors_Homo sapiens_hsa030222.75532631
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64627936
8Caffeine metabolism_Homo sapiens_hsa002322.57316818
9Nitrogen metabolism_Homo sapiens_hsa009102.26224115
10Mismatch repair_Homo sapiens_hsa034302.19906932
11Propanoate metabolism_Homo sapiens_hsa006402.16954223
12Steroid biosynthesis_Homo sapiens_hsa001002.08041815
13RNA degradation_Homo sapiens_hsa030182.04102892
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01635799
15Butanoate metabolism_Homo sapiens_hsa006502.00029866
16p53 signaling pathway_Homo sapiens_hsa041151.89969044
17Cell cycle_Homo sapiens_hsa041101.81970288
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80080870
19Circadian rhythm_Homo sapiens_hsa047101.73988884
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72208514
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64318311
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62791217
23DNA replication_Homo sapiens_hsa030301.62385027
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61014705
25Fatty acid elongation_Homo sapiens_hsa000621.59850379
26Base excision repair_Homo sapiens_hsa034101.51560085
27One carbon pool by folate_Homo sapiens_hsa006701.47500535
28RNA transport_Homo sapiens_hsa030131.46613775
29Selenocompound metabolism_Homo sapiens_hsa004501.45549616
30Nucleotide excision repair_Homo sapiens_hsa034201.40907258
31RNA polymerase_Homo sapiens_hsa030201.36850390
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.31229764
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25052010
34Sphingolipid metabolism_Homo sapiens_hsa006001.19519239
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11045544
36Renin-angiotensin system_Homo sapiens_hsa046141.10158965
37Lysine degradation_Homo sapiens_hsa003101.05176302
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.04223162
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03260826
40Phototransduction_Homo sapiens_hsa047441.02908024
41Oxidative phosphorylation_Homo sapiens_hsa001901.01158428
42Spliceosome_Homo sapiens_hsa030400.97069440
43Oocyte meiosis_Homo sapiens_hsa041140.95730579
44Basal cell carcinoma_Homo sapiens_hsa052170.91035303
45Taste transduction_Homo sapiens_hsa047420.90765649
46Hedgehog signaling pathway_Homo sapiens_hsa043400.88966835
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86815510
48Huntingtons disease_Homo sapiens_hsa050160.85362062
49Olfactory transduction_Homo sapiens_hsa047400.85029535
50Ether lipid metabolism_Homo sapiens_hsa005650.83905731
51mRNA surveillance pathway_Homo sapiens_hsa030150.83108300
52Parkinsons disease_Homo sapiens_hsa050120.81374088
53Glutathione metabolism_Homo sapiens_hsa004800.80294086
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79700847
55Purine metabolism_Homo sapiens_hsa002300.78097221
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76704100
57Peroxisome_Homo sapiens_hsa041460.74021881
58Linoleic acid metabolism_Homo sapiens_hsa005910.73470494
59Vitamin digestion and absorption_Homo sapiens_hsa049770.73203566
60Prostate cancer_Homo sapiens_hsa052150.73146949
61Retinol metabolism_Homo sapiens_hsa008300.71650471
62Pyruvate metabolism_Homo sapiens_hsa006200.71253626
63Proteasome_Homo sapiens_hsa030500.71105998
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70936802
65Alcoholism_Homo sapiens_hsa050340.70279227
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68434546
67Fatty acid metabolism_Homo sapiens_hsa012120.64137986
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63966599
69beta-Alanine metabolism_Homo sapiens_hsa004100.63186090
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.61317166
71Pyrimidine metabolism_Homo sapiens_hsa002400.60682912
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60542855
73Fat digestion and absorption_Homo sapiens_hsa049750.59688219
74Systemic lupus erythematosus_Homo sapiens_hsa053220.57303048
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57089448
76TGF-beta signaling pathway_Homo sapiens_hsa043500.55973284
77Nicotine addiction_Homo sapiens_hsa050330.55381584
78Metabolic pathways_Homo sapiens_hsa011000.52198270
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51702651
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50923240
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48103213
82Chemical carcinogenesis_Homo sapiens_hsa052040.46439797
83FoxO signaling pathway_Homo sapiens_hsa040680.40397596
84Regulation of autophagy_Homo sapiens_hsa041400.40012297
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.38888928
86MicroRNAs in cancer_Homo sapiens_hsa052060.38847439
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38153024
88Wnt signaling pathway_Homo sapiens_hsa043100.37133332
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33246763
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32991705
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32644545
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31488817
93Axon guidance_Homo sapiens_hsa043600.28168922
94Tyrosine metabolism_Homo sapiens_hsa003500.25002631
95Alzheimers disease_Homo sapiens_hsa050100.24842082
96Collecting duct acid secretion_Homo sapiens_hsa049660.24048834
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23052858
98Dopaminergic synapse_Homo sapiens_hsa047280.21701210
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21388534
100Glutamatergic synapse_Homo sapiens_hsa047240.20591087

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