CBX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.34144705
2regulation of gene silencing by miRNA (GO:0060964)6.34144705
3regulation of gene silencing by RNA (GO:0060966)6.34144705
4pre-miRNA processing (GO:0031054)5.58605453
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.47829645
6synaptic vesicle maturation (GO:0016188)5.37618633
7histone H4-K12 acetylation (GO:0043983)5.12425321
8negative regulation of histone methylation (GO:0031061)5.07346014
9synaptic vesicle exocytosis (GO:0016079)4.78007419
10glutamate secretion (GO:0014047)4.66082579
11determination of adult lifespan (GO:0008340)4.47809982
12regulation of synaptic vesicle exocytosis (GO:2000300)4.43699652
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.39033323
14cellular potassium ion homeostasis (GO:0030007)4.38308862
15regulation of ARF protein signal transduction (GO:0032012)4.33826544
16sodium ion export (GO:0071436)4.26895041
17regulation of translational fidelity (GO:0006450)4.15277328
18histone H4-K8 acetylation (GO:0043982)4.00554431
19histone H4-K5 acetylation (GO:0043981)4.00554431
20regulation of histone H3-K9 methylation (GO:0051570)4.00511265
21nuclear pore organization (GO:0006999)3.96212232
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90998371
23cerebellar granule cell differentiation (GO:0021707)3.87867170
24regulation of synaptic vesicle transport (GO:1902803)3.87659773
25nuclear pore complex assembly (GO:0051292)3.86787548
26embryonic process involved in female pregnancy (GO:0060136)3.83223073
27L-amino acid import (GO:0043092)3.79224680
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76076556
29positive regulation of Rap GTPase activity (GO:0032854)3.74113005
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.73774430
31positive thymic T cell selection (GO:0045059)3.73269051
32regulation of gamma-delta T cell differentiation (GO:0045586)3.71775687
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.70116834
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.70116834
35regulation of telomere maintenance via telomerase (GO:0032210)3.68745318
36trophectodermal cell differentiation (GO:0001829)3.68471027
37positive regulation of synapse maturation (GO:0090129)3.67228408
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65365517
39neurotransmitter secretion (GO:0007269)3.64191149
40regulation of histone H3-K27 methylation (GO:0061085)3.63267947
41histone H4-K16 acetylation (GO:0043984)3.62646274
42regulation of gene silencing (GO:0060968)3.58668390
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57983294
44heterochromatin organization (GO:0070828)3.55397519
45negative regulation of cell killing (GO:0031342)3.53115708
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53115708
47regulation of hippo signaling (GO:0035330)3.49555854
48positive regulation of gamma-delta T cell activation (GO:0046645)3.48358647
49regulation of helicase activity (GO:0051095)3.47246131
50thymic T cell selection (GO:0045061)3.42787493
51nodal signaling pathway (GO:0038092)3.42255445
52locomotory exploration behavior (GO:0035641)3.39172508
53establishment of apical/basal cell polarity (GO:0035089)3.34710890
54regulation of Rap GTPase activity (GO:0032317)3.32615592
55potassium ion import (GO:0010107)3.30928977
56positive regulation of SMAD protein import into nucleus (GO:0060391)3.28207277
57histone H2A monoubiquitination (GO:0035518)3.28205553
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25400363
59negative regulation of gene silencing (GO:0060969)3.22092503
60negative thymic T cell selection (GO:0045060)3.17985646
61regulation of gamma-delta T cell activation (GO:0046643)3.17127914
62DNA duplex unwinding (GO:0032508)3.15599815
63positive regulation of gene expression, epigenetic (GO:0045815)3.15523193
64negative T cell selection (GO:0043383)3.14967643
65regulation of translational termination (GO:0006449)3.14788532
66DNA geometric change (GO:0032392)3.13371310
67folic acid-containing compound biosynthetic process (GO:0009396)3.11759970
68potassium ion homeostasis (GO:0055075)3.11712217
69intracellular estrogen receptor signaling pathway (GO:0030520)3.10480888
70mitotic G1 DNA damage checkpoint (GO:0031571)3.07886067
71T cell selection (GO:0045058)3.07865455
72regulation of synapse maturation (GO:0090128)3.03541628
73positive T cell selection (GO:0043368)3.02670072
74pore complex assembly (GO:0046931)3.02293578
75histone H3-K4 methylation (GO:0051568)3.02288317
76signal complex assembly (GO:0007172)3.01816168
77amino acid import (GO:0043090)3.00795079
78regulation of neuronal synaptic plasticity (GO:0048168)3.00668745
79anterior/posterior axis specification, embryo (GO:0008595)2.98905049
80negative regulation of chromatin modification (GO:1903309)2.98284541
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94282987
82mitotic nuclear envelope disassembly (GO:0007077)2.93380179
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92553012
84negative regulation of histone modification (GO:0031057)2.91029131
85negative regulation of erythrocyte differentiation (GO:0045647)2.90952521
86neurotransmitter transport (GO:0006836)2.90855250
87chromatin silencing (GO:0006342)2.88255387
88positive regulation of histone deacetylation (GO:0031065)2.86542608
89cell communication by electrical coupling (GO:0010644)2.85401310
90regulation of voltage-gated calcium channel activity (GO:1901385)2.82752277
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81516587
92embryonic placenta development (GO:0001892)2.81118369
93neuronal action potential propagation (GO:0019227)2.80543245
94nuclear envelope disassembly (GO:0051081)2.80086050
95membrane disassembly (GO:0030397)2.80086050
96regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.79309822
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.79055427
98regulation of translation, ncRNA-mediated (GO:0045974)2.79055427
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79055427
100antigen processing and presentation of endogenous antigen (GO:0019883)2.78713097
101dosage compensation (GO:0007549)2.77636088
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77125316
103ionotropic glutamate receptor signaling pathway (GO:0035235)2.77090888
104IMP biosynthetic process (GO:0006188)2.75720926
105cerebellar Purkinje cell differentiation (GO:0021702)2.74442777
106regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73769913
107chromatin assembly (GO:0031497)2.72924214
108neuronal ion channel clustering (GO:0045161)2.71723939
109NLS-bearing protein import into nucleus (GO:0006607)2.71691900
110apoptotic process involved in morphogenesis (GO:0060561)2.71342831
111intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.71342770
112regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.71120106
113regulation of histone methylation (GO:0031060)2.70317484
114spliceosomal tri-snRNP complex assembly (GO:0000244)2.68735757
115activation of protein kinase A activity (GO:0034199)2.68617835
116negative regulation of telomerase activity (GO:0051974)2.68446663
117mitochondrial DNA metabolic process (GO:0032042)2.68113022
118mitotic G1/S transition checkpoint (GO:0044819)2.67990129
119regulation of synaptic plasticity (GO:0048167)2.64775083
120regulation of neurotransmitter levels (GO:0001505)2.64106577
121long-term memory (GO:0007616)2.63960208
122cellular sodium ion homeostasis (GO:0006883)2.63743617
123regulation of glutamate receptor signaling pathway (GO:1900449)2.60677933
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.60369727
125negative regulation of dendrite morphogenesis (GO:0050774)2.60093616
126peptidyl-lysine dimethylation (GO:0018027)2.59671709
127mRNA cleavage (GO:0006379)2.59312104
128exploration behavior (GO:0035640)2.58795957
129DNA unwinding involved in DNA replication (GO:0006268)2.58657685
130regulation of RNA export from nucleus (GO:0046831)2.58351776
131neuromuscular process controlling balance (GO:0050885)2.58273325
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.57742389
133establishment of monopolar cell polarity (GO:0061162)2.57742389
134regulation of T-helper 2 cell differentiation (GO:0045628)2.57653742
135response to interleukin-15 (GO:0070672)2.57421092
136viral transcription (GO:0019083)2.57331843
137regulation of B cell receptor signaling pathway (GO:0050855)2.55952674
138negative regulation of lymphocyte mediated immunity (GO:0002707)2.55765046
139positive regulation of membrane potential (GO:0045838)2.54784835
140peptidyl-arginine omega-N-methylation (GO:0035247)2.53963620
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53881846
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53694347
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53694347
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.53470572
145histone arginine methylation (GO:0034969)2.52954145
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52333870
147gamma-aminobutyric acid signaling pathway (GO:0007214)2.51698432
148regulation of neurotransmitter secretion (GO:0046928)2.51615102
149protein localization to kinetochore (GO:0034501)2.51043855
150G1 DNA damage checkpoint (GO:0044783)2.50865854
151axon ensheathment in central nervous system (GO:0032291)2.50240654
152central nervous system myelination (GO:0022010)2.50240654
153vocalization behavior (GO:0071625)2.49850750
154regulation of beta-amyloid formation (GO:1902003)2.49664020
155histone methylation (GO:0016571)2.49433042
156mitotic sister chromatid segregation (GO:0000070)2.49342143
157gene silencing (GO:0016458)2.49211681
158detection of calcium ion (GO:0005513)2.48685139
159B cell receptor signaling pathway (GO:0050853)2.48528394
160regulation of chromatin silencing (GO:0031935)2.47766165
161ribosome biogenesis (GO:0042254)2.47697106
162histone H4 acetylation (GO:0043967)2.47092092
163negative regulation of mRNA processing (GO:0050686)2.46687958
164nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46565628
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.46178007
166histone H3 acetylation (GO:0043966)2.45972926
167regulation of synapse structural plasticity (GO:0051823)2.45102188
168regulation of ARF GTPase activity (GO:0032312)2.44515068
169long-term synaptic potentiation (GO:0060291)2.44405436
170macrophage activation involved in immune response (GO:0002281)2.42695976
171regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42464950
172positive regulation of neurotransmitter secretion (GO:0001956)2.41315560
173regulation of amyloid precursor protein catabolic process (GO:1902991)2.39522723
174negative regulation of leukocyte mediated immunity (GO:0002704)2.39192501
175G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.37080313
176cellular response to epinephrine stimulus (GO:0071872)2.33590219
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.32875726
178negative regulation of type 2 immune response (GO:0002829)2.30849035
179detection of bacterium (GO:0016045)2.30582340
180detection of other organism (GO:0098543)2.30118042
181positive regulation of fibroblast migration (GO:0010763)2.28420831
182neurotransmitter uptake (GO:0001504)2.25517268
183regulation of vesicle fusion (GO:0031338)2.25316549
184membrane depolarization during action potential (GO:0086010)2.23926503
185cell differentiation in hindbrain (GO:0021533)2.22253213
186cell communication involved in cardiac conduction (GO:0086065)2.21948473
187positive regulation of neurotransmitter transport (GO:0051590)2.20917796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.99615757
2MYC_22102868_ChIP-Seq_BL_Human3.49447709
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.39587628
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.32154986
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.32154986
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.32154986
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.31455019
8DROSHA_22980978_ChIP-Seq_HELA_Human2.73882678
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.71336575
10EZH2_22144423_ChIP-Seq_EOC_Human2.70430557
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.57176652
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50418017
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44188695
14* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.32384724
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27693326
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.26288159
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25521448
18* MYC_18555785_ChIP-Seq_MESCs_Mouse2.20974248
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.17343105
20* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09943453
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02791538
22VDR_21846776_ChIP-Seq_THP-1_Human2.01970073
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97054147
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95949580
25* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90530225
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90357912
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89552182
28* KDM2B_26808549_Chip-Seq_K562_Human1.89187854
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86972887
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86248752
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.85047892
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83999417
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80578813
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.78826390
35* KDM2B_26808549_Chip-Seq_DND41_Human1.78608774
36CIITA_25753668_ChIP-Seq_RAJI_Human1.77957633
37* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77781883
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77267641
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76932469
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73045064
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72206300
42REST_21632747_ChIP-Seq_MESCs_Mouse1.70947021
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69324856
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69073486
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.68511470
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67711156
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67412754
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67387900
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66592069
50* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65879888
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61701366
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60334433
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60324422
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.60109650
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59265384
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57610265
57* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56914699
58* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.56854168
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.56708664
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55889941
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.54688860
62MAF_26560356_Chip-Seq_TH1_Human1.54541423
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54410445
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54297410
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.53029078
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52916593
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50837608
68UTX_26944678_Chip-Seq_JUKART_Human1.47913215
69* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47770606
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.47254821
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45556173
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.44265037
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42735172
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42382984
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42382984
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39451639
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36139463
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35812412
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34797067
80MYB_26560356_Chip-Seq_TH1_Human1.33597185
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.33155035
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.31605170
83SMC4_20622854_ChIP-Seq_HELA_Human1.31027016
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30675005
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.29477388
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28540997
87* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28290609
88* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28166537
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27172345
90ZNF263_19887448_ChIP-Seq_K562_Human1.26758377
91* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26311650
92SPI1_23127762_ChIP-Seq_K562_Human1.26111454
93MAF_26560356_Chip-Seq_TH2_Human1.25708565
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24900834
95* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24592429
96* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23909380
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23395511
98* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22807671
99* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22795071
100XRN2_22483619_ChIP-Seq_HELA_Human1.22597944
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21502433
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.21245294
103GATA1_19941826_ChIP-Seq_K562_Human1.20827138
104CTCF_27219007_Chip-Seq_Bcells_Human1.20316616
105SCL_19346495_ChIP-Seq_HPC-7_Human1.18672635
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18579048
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16444286
108* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15909716
109* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14917106
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13478702
111VDR_24763502_ChIP-Seq_THP-1_Human1.13222733
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13019468
113MYB_26560356_Chip-Seq_TH2_Human1.13013294
114KDM5A_27292631_Chip-Seq_BREAST_Human1.12347729
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12223610
116OCT4_19829295_ChIP-Seq_ESCs_Human1.12186876
117NCOR1_26117541_ChIP-Seq_K562_Human1.12132938
118LXR_22292898_ChIP-Seq_THP-1_Human1.12044953
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11649439
120NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10466029
121EZH2_27304074_Chip-Seq_ESCs_Mouse1.10342520
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10242166
123* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08600934
124CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08530440
125KAP1_27257070_Chip-Seq_ESCs_Mouse1.08415773
126* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08336726
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08201408
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07211171
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07165943
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06859537
131* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06811293
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06384671
133* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05974047
134SA1_27219007_Chip-Seq_ERYTHROID_Human1.04870917
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04792144
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.03991155
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03912255
138RUNX_20019798_ChIP-Seq_JUKART_Human1.03187741
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02994058
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01949429
141CREB1_26743006_Chip-Seq_LNCaP_Human1.01849503
142* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01025694
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00950466
144P68_20966046_ChIP-Seq_HELA_Human1.00793662
145TFEB_21752829_ChIP-Seq_HELA_Human1.00330366
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00022246
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.99580094
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.99571676
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98818618
150RACK7_27058665_Chip-Seq_MCF-7_Human0.97969470
151* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97631954
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97445712
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96349712
154RUNX1_22412390_ChIP-Seq_EML_Mouse0.96009859
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95894769
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.95311683
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94111386
158GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94091549
159NOTCH1_21737748_ChIP-Seq_TLL_Human0.93971627
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93874718
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92809974
162* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92643060
163SA1_27219007_Chip-Seq_Bcells_Human0.92575424
164PHF8_20622854_ChIP-Seq_HELA_Human0.92564425
165KLF4_19829295_ChIP-Seq_ESCs_Human0.91759473
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91306252
167BCOR_27268052_Chip-Seq_Bcells_Human0.90586867
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90452747
169SMAD_19615063_ChIP-ChIP_OVARY_Human0.90412263
170ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90381085
171GATA2_21666600_ChIP-Seq_HMVEC_Human0.89179714
172SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88705486
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86199281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.04205246
2MP0003880_abnormal_central_pattern3.52731286
3MP0008057_abnormal_DNA_replication3.25674557
4MP0004270_analgesia3.23293983
5MP0003763_abnormal_thymus_physiology3.10828547
6MP0003635_abnormal_synaptic_transmissio2.99461065
7MP0002064_seizures2.91258900
8MP0005423_abnormal_somatic_nervous2.86861954
9MP0004957_abnormal_blastocyst_morpholog2.84624858
10MP0002653_abnormal_ependyma_morphology2.83230774
11MP0010352_gastrointestinal_tract_polyps2.74060879
12MP0010234_abnormal_vibrissa_follicle2.54562686
13MP0003879_abnormal_hair_cell2.48485614
14MP0009745_abnormal_behavioral_response2.43159380
15MP0008569_lethality_at_weaning2.42726144
16MP0003111_abnormal_nucleus_morphology2.40008958
17MP0001501_abnormal_sleep_pattern2.38262458
18MP0003690_abnormal_glial_cell2.37408587
19MP0002063_abnormal_learning/memory/cond2.37371198
20MP0008961_abnormal_basal_metabolism2.32904937
21MP0010094_abnormal_chromosome_stability2.31664950
22MP0003077_abnormal_cell_cycle2.31114113
23MP0004264_abnormal_extraembryonic_tissu2.24244787
24MP0003724_increased_susceptibility_to2.24096317
25MP0003329_amyloid_beta_deposits2.19097098
26MP0003693_abnormal_embryo_hatching2.18025106
27MP0004133_heterotaxia2.17571088
28MP0003303_peritoneal_inflammation2.11012623
29MP0002272_abnormal_nervous_system2.10546621
30MP0001486_abnormal_startle_reflex2.02588698
31MP0001800_abnormal_humoral_immune2.02374784
32MP0009046_muscle_twitch1.99891604
33MP0003436_decreased_susceptibility_to1.94660620
34MP0000350_abnormal_cell_proliferation1.92696787
35MP0005076_abnormal_cell_differentiation1.87047318
36MP0000703_abnormal_thymus_morphology1.84300380
37MP0004130_abnormal_muscle_cell1.84086684
38MP0002734_abnormal_mechanical_nocicepti1.83457058
39MP0000685_abnormal_immune_system1.83211484
40MP0002398_abnormal_bone_marrow1.80911284
41MP0001968_abnormal_touch/_nociception1.80289867
42MP0002572_abnormal_emotion/affect_behav1.77649979
43MP0000920_abnormal_myelination1.75751699
44MP0005670_abnormal_white_adipose1.72818919
45MP0001730_embryonic_growth_arrest1.71929249
46MP0002396_abnormal_hematopoietic_system1.71724005
47MP0005671_abnormal_response_to1.69493779
48MP0000689_abnormal_spleen_morphology1.66067582
49MP0002084_abnormal_developmental_patter1.65658645
50MP0002086_abnormal_extraembryonic_tissu1.64140698
51MP0003283_abnormal_digestive_organ1.63731991
52MP0002722_abnormal_immune_system1.62549301
53MP0005387_immune_system_phenotype1.62191423
54MP0001790_abnormal_immune_system1.62191423
55MP0008058_abnormal_DNA_repair1.60083589
56MP0001849_ear_inflammation1.57952596
57MP0002254_reproductive_system_inflammat1.57905315
58MP0003119_abnormal_digestive_system1.56979229
59MP0005380_embryogenesis_phenotype1.56205209
60MP0001672_abnormal_embryogenesis/_devel1.56205209
61MP0003890_abnormal_embryonic-extraembry1.55972405
62MP0003566_abnormal_cell_adhesion1.55214962
63MP0003075_altered_response_to1.47173848
64MP0001697_abnormal_embryo_size1.42856269
65MP0000716_abnormal_immune_system1.42814452
66MP0004197_abnormal_fetal_growth/weight/1.42272589
67MP0008260_abnormal_autophagy1.41604874
68MP0008874_decreased_physiological_sensi1.41464610
69MP0001970_abnormal_pain_threshold1.39924842
70MP0009278_abnormal_bone_marrow1.39670731
71MP0002085_abnormal_embryonic_tissue1.38304119
72MP0003633_abnormal_nervous_system1.38081111
73MP0003984_embryonic_growth_retardation1.37665304
74MP0002088_abnormal_embryonic_growth/wei1.36693433
75MP0009780_abnormal_chondrocyte_physiolo1.35182939
76MP0002733_abnormal_thermal_nociception1.34769721
77MP0003787_abnormal_imprinting1.33519987
78MP0003191_abnormal_cellular_cholesterol1.33171441
79MP0001440_abnormal_grooming_behavior1.32655239
80MP0002080_prenatal_lethality1.32584443
81MP0003866_abnormal_defecation1.32124839
82MP0000490_abnormal_crypts_of1.30554750
83MP0010307_abnormal_tumor_latency1.29377773
84MP0000604_amyloidosis1.29310188
85MP0002735_abnormal_chemical_nociception1.28976909
86MP0003123_paternal_imprinting1.28787693
87MP0008007_abnormal_cellular_replicative1.28408247
88MP0008877_abnormal_DNA_methylation1.28158355
89MP0003183_abnormal_peptide_metabolism1.28140557
90MP0001502_abnormal_circadian_rhythm1.27739760
91MP0001835_abnormal_antigen_presentation1.27212063
92MP0002420_abnormal_adaptive_immunity1.25990379
93MP0002452_abnormal_antigen_presenting1.24837436
94MP0002429_abnormal_blood_cell1.24674585
95MP0000751_myopathy1.24571959
96MP0002019_abnormal_tumor_incidence1.23726635
97MP0002067_abnormal_sensory_capabilities1.23336800
98MP0005167_abnormal_blood-brain_barrier1.23032889
99MP0001819_abnormal_immune_cell1.22622901
100MP0005535_abnormal_body_temperature1.22179467
101MP0002723_abnormal_immune_serum1.21924701
102MP0005025_abnormal_response_to1.21182252
103MP0005166_decreased_susceptibility_to1.19605624
104MP0002419_abnormal_innate_immunity1.16381711
105MP0001873_stomach_inflammation1.15991561
106MP0002405_respiratory_system_inflammati1.15725528
107MP0003453_abnormal_keratinocyte_physiol1.13382370
108MP0010155_abnormal_intestine_physiology1.10806332
109MP0001986_abnormal_taste_sensitivity1.09933796
110MP0000313_abnormal_cell_death1.09343789
111MP0004885_abnormal_endolymph1.07931065
112MP0003631_nervous_system_phenotype1.07221736
113MP0003705_abnormal_hypodermis_morpholog1.06338861
114MP0002877_abnormal_melanocyte_morpholog1.04593007
115MP0002822_catalepsy1.03864899
116MP0002066_abnormal_motor_capabilities/c1.03743269
117MP0004808_abnormal_hematopoietic_stem1.03180123
118MP0008770_decreased_survivor_rate1.02933312
119MP0004185_abnormal_adipocyte_glucose1.02240563
120MP0005023_abnormal_wound_healing1.00042715
121MP0003786_premature_aging0.99575375
122MP0005666_abnormal_adipose_tissue0.99417169
123MP0004484_altered_response_of0.98913825
124MP0001348_abnormal_lacrimal_gland0.98493013
125MP0001293_anophthalmia0.97261114
126MP0001533_abnormal_skeleton_physiology0.96946619
127MP0004811_abnormal_neuron_physiology0.96528423
128MP0002332_abnormal_exercise_endurance0.95711221
129MP0006082_CNS_inflammation0.93948052
130MP0004036_abnormal_muscle_relaxation0.93629001
131MP0006072_abnormal_retinal_apoptosis0.92535565
132MP0005000_abnormal_immune_tolerance0.91795998
133MP0001851_eye_inflammation0.91510094
134MP0009333_abnormal_splenocyte_physiolog0.90291725
135MP0002909_abnormal_adrenal_gland0.88928297
136MP0000747_muscle_weakness0.88838355
137MP0003300_gastrointestinal_ulcer0.87828486
138MP0005397_hematopoietic_system_phenotyp0.87827216
139MP0001545_abnormal_hematopoietic_system0.87827216
140MP0005621_abnormal_cell_physiology0.87788092
141MP0002796_impaired_skin_barrier0.87634515
142MP0004510_myositis0.87544620
143MP0002269_muscular_atrophy0.87376584
144MP0002127_abnormal_cardiovascular_syste0.87114901
145MP0001958_emphysema0.86665090
146MP0002166_altered_tumor_susceptibility0.86477538
147MP0008872_abnormal_physiological_respon0.85933609
148MP0004947_skin_inflammation0.85408986
149MP0003634_abnormal_glial_cell0.85205136
150MP0005375_adipose_tissue_phenotype0.83994372
151MP0003172_abnormal_lysosome_physiology0.83986124
152MP0003045_fibrosis0.83525826
153MP0000477_abnormal_intestine_morphology0.83374185
154MP0001765_abnormal_ion_homeostasis0.83005951
155MP0004233_abnormal_muscle_weight0.82282555
156MP0005058_abnormal_lysosome_morphology0.82040060
157MP0005386_behavior/neurological_phenoty0.82000989
158MP0004924_abnormal_behavior0.82000989
159MP0003828_pulmonary_edema0.77593114
160MP0004381_abnormal_hair_follicle0.76935756
161MP0004145_abnormal_muscle_electrophysio0.75871335
162MP0002557_abnormal_social/conspecific_i0.75256699
163MP0005384_cellular_phenotype0.74956607
164MP0002229_neurodegeneration0.74594353
165MP0005451_abnormal_body_composition0.73341845
166MP0005266_abnormal_metabolism0.73227592
167MP0002998_abnormal_bone_remodeling0.73103952
168MP0002133_abnormal_respiratory_system0.71612593
169MP0005388_respiratory_system_phenotype0.71612593
170MP0002971_abnormal_brown_adipose0.71078672
171MP0003646_muscle_fatigue0.70837324
172MP0009785_altered_susceptibility_to0.69951215
173MP0004742_abnormal_vestibular_system0.66438259
174MP0002933_joint_inflammation0.66353553
175MP0005464_abnormal_platelet_physiology0.66236687

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.31694008
2Myokymia (HP:0002411)4.63130118
3Diplopia (HP:0000651)4.43800367
4Abnormality of binocular vision (HP:0011514)4.43800367
5Focal motor seizures (HP:0011153)4.29726601
6Obstructive sleep apnea (HP:0002870)4.06708178
7Supranuclear gaze palsy (HP:0000605)4.06509410
8Papilledema (HP:0001085)4.05369520
9Basal cell carcinoma (HP:0002671)3.85242178
10Ankle clonus (HP:0011448)3.74083211
11Febrile seizures (HP:0002373)3.65357793
12Rib fusion (HP:0000902)3.64600813
13Abnormality of the astrocytes (HP:0100707)3.59147600
14Astrocytoma (HP:0009592)3.59147600
15Eczematoid dermatitis (HP:0000976)3.53805198
16Neoplasm of the oral cavity (HP:0100649)3.53163181
17Focal seizures (HP:0007359)3.45952016
18Action tremor (HP:0002345)3.36012924
19Atonic seizures (HP:0010819)3.16602338
20Neurofibrillary tangles (HP:0002185)3.14496373
21Epileptic encephalopathy (HP:0200134)3.11530434
22Abnormality of the lower motor neuron (HP:0002366)3.10528002
23Visual hallucinations (HP:0002367)3.09515434
24Postural instability (HP:0002172)3.07756688
25Ventricular fibrillation (HP:0001663)3.04833324
26Hemiplegia (HP:0002301)3.03714890
27Annular pancreas (HP:0001734)2.94915890
28Slow saccadic eye movements (HP:0000514)2.88339779
29Abnormality of the salivary glands (HP:0010286)2.87496018
30Nasal polyposis (HP:0100582)2.84790339
31Intestinal fistula (HP:0100819)2.81503515
32Recurrent bronchitis (HP:0002837)2.81207630
33Spastic gait (HP:0002064)2.80886799
34Rhabdomyosarcoma (HP:0002859)2.79834032
35Medulloblastoma (HP:0002885)2.79646117
36Hyporeflexia of lower limbs (HP:0002600)2.78764474
37Neoplasm of striated muscle (HP:0009728)2.77499181
38Asplenia (HP:0001746)2.77183733
39Panhypogammaglobulinemia (HP:0003139)2.74503789
40Neuronal loss in central nervous system (HP:0002529)2.68381448
41Tetraplegia (HP:0002445)2.63680144
42Abnormality of the fingertips (HP:0001211)2.63314643
43Muscle fiber splitting (HP:0003555)2.62329558
44Glioma (HP:0009733)2.61003606
45Difficulty running (HP:0009046)2.60752739
46Cerebral inclusion bodies (HP:0100314)2.58559582
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.58225375
48Bundle branch block (HP:0011710)2.57727635
49Abnormality of the nasal mucosa (HP:0000433)2.56393689
50Anal stenosis (HP:0002025)2.55489639
51Abnormal eating behavior (HP:0100738)2.54734531
52T lymphocytopenia (HP:0005403)2.53645754
53Abnormality of the labia minora (HP:0012880)2.53086220
54Myositis (HP:0100614)2.52564980
55Intention tremor (HP:0002080)2.52271441
56Missing ribs (HP:0000921)2.50938799
57Exercise-induced myalgia (HP:0003738)2.49397472
58Generalized tonic-clonic seizures (HP:0002069)2.48827075
59Supernumerary spleens (HP:0009799)2.47543461
60Truncal ataxia (HP:0002078)2.46759984
61Colitis (HP:0002583)2.46185062
62Rigidity (HP:0002063)2.45303578
63Biliary tract neoplasm (HP:0100574)2.45096900
64Amaurosis fugax (HP:0100576)2.45036062
65Colon cancer (HP:0003003)2.43962132
66IgM deficiency (HP:0002850)2.43057379
67Rapidly progressive (HP:0003678)2.42957997
68Cellulitis (HP:0100658)2.42729701
69Prominent nose (HP:0000448)2.42456247
70Selective tooth agenesis (HP:0001592)2.41631987
71Resting tremor (HP:0002322)2.39936681
72Peripheral hypomyelination (HP:0007182)2.39685966
73Agammaglobulinemia (HP:0004432)2.39369858
74Pustule (HP:0200039)2.37092687
75Depression (HP:0000716)2.34874854
76Dysmetria (HP:0001310)2.34780265
77Impaired smooth pursuit (HP:0007772)2.32884200
78Agnosia (HP:0010524)2.32298407
79Absence seizures (HP:0002121)2.31551878
80Heterotopia (HP:0002282)2.30193163
81Abnormality of T cell number (HP:0011839)2.28275599
82Orchitis (HP:0100796)2.27716139
83Mutism (HP:0002300)2.27541603
84Recurrent bacterial skin infections (HP:0005406)2.27428176
85Recurrent abscess formation (HP:0002722)2.27157723
86Short humerus (HP:0005792)2.26751121
87Gastrointestinal inflammation (HP:0004386)2.21755345
88Recurrent gram-negative bacterial infections (HP:0005420)2.21483822
89Rectal fistula (HP:0100590)2.20743039
90Rectovaginal fistula (HP:0000143)2.20743039
91Esophageal atresia (HP:0002032)2.19357836
92Abnormality of saccadic eye movements (HP:0000570)2.17050787
93Aplasia/hypoplasia of the humerus (HP:0006507)2.16491470
94Vertebral clefting (HP:0008428)2.14645551
95Abnormality of ocular smooth pursuit (HP:0000617)2.13936372
96Supernumerary ribs (HP:0005815)2.13771350
97Absent thumb (HP:0009777)2.13519940
98Combined immunodeficiency (HP:0005387)2.12705210
99Abnormality of T cells (HP:0002843)2.12620654
100Progressive cerebellar ataxia (HP:0002073)2.12597690
101Abnormal delayed hypersensitivity skin test (HP:0002963)2.11196067
102Recurrent viral infections (HP:0004429)2.10504897
103Inflammation of the large intestine (HP:0002037)2.10110773
104Optic neuritis (HP:0100653)2.09892486
105Retrobulbar optic neuritis (HP:0100654)2.09892486
106Emphysema (HP:0002097)2.07478051
107Urinary bladder sphincter dysfunction (HP:0002839)2.07214205
108Abnormality of macrophages (HP:0004311)2.06582975
109Torticollis (HP:0000473)2.05868864
110Heart block (HP:0012722)2.05048900
111Sudden death (HP:0001699)2.04755462
112Meningitis (HP:0001287)2.04674681
113Bradykinesia (HP:0002067)2.04221881
114Malignant gastrointestinal tract tumors (HP:0006749)2.03884183
115Gastrointestinal carcinoma (HP:0002672)2.03884183
116Skin tags (HP:0010609)2.03852984
117Shawl scrotum (HP:0000049)2.03391234
118Bronchitis (HP:0012387)2.03320731
119Dysmetric saccades (HP:0000641)2.03010028
120Urethral obstruction (HP:0000796)2.02690499
121EMG: neuropathic changes (HP:0003445)2.01439188
122Pseudobulbar signs (HP:0002200)2.00613565
123Dialeptic seizures (HP:0011146)2.00552426
124Gastrointestinal infarctions (HP:0005244)1.99762974
125Lower limb muscle weakness (HP:0007340)1.99569438
126Increased IgE level (HP:0003212)1.98678789
127Spontaneous hematomas (HP:0007420)1.98283173
128B lymphocytopenia (HP:0010976)1.98171407
129Abnormality of B cell number (HP:0010975)1.98171407
130Abnormal EKG (HP:0003115)1.98109235
131Foot dorsiflexor weakness (HP:0009027)1.98061400
132Supernumerary bones of the axial skeleton (HP:0009144)1.97315631
133Abnormal number of incisors (HP:0011064)1.97041066
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.96146739
135Absent radius (HP:0003974)1.94760837
136Prolonged QT interval (HP:0001657)1.93895008
137Increased variability in muscle fiber diameter (HP:0003557)1.92388250
138EMG: myopathic abnormalities (HP:0003458)1.91918182
139Spinal canal stenosis (HP:0003416)1.91014975
140Broad palm (HP:0001169)1.91006789
141Abnormal atrioventricular conduction (HP:0005150)1.90583274
142Sleep apnea (HP:0010535)1.89338974
143Clonus (HP:0002169)1.87881858
144Cafe-au-lait spot (HP:0000957)1.87619046
145Mediastinal lymphadenopathy (HP:0100721)1.87076644
146Hypercortisolism (HP:0001578)1.86904773
147Increased circulating renin level (HP:0000848)1.86873712
148Vaginal fistula (HP:0004320)1.86829659
149Gastrointestinal stroma tumor (HP:0100723)1.86729835
150Abnormality of the foot musculature (HP:0001436)1.86512684
151Lymphoma (HP:0002665)1.86094695
152Gingivitis (HP:0000230)1.86078699
153Ocular albinism (HP:0001107)1.85519159
154Cerebral hypomyelination (HP:0006808)1.85034421
155Delusions (HP:0000746)1.84233761
156Depressed nasal tip (HP:0000437)1.83963680
157Stomatitis (HP:0010280)1.83668950
158Vertebral arch anomaly (HP:0008438)1.83224487
159Stereotypic behavior (HP:0000733)1.82538441
160Vertigo (HP:0002321)1.82259760
161Scanning speech (HP:0002168)1.82132310
162Status epilepticus (HP:0002133)1.81926775
163Increased connective tissue (HP:0009025)1.81413571
164Abnormality of skeletal muscle fiber size (HP:0012084)1.80863039
165Ventricular arrhythmia (HP:0004308)1.79834039
166Memory impairment (HP:0002354)1.79723062
167Anxiety (HP:0000739)1.79579239
168Impulsivity (HP:0100710)1.79265670
169Aplasia involving forearm bones (HP:0009822)1.78991508
170Absent forearm bone (HP:0003953)1.78991508
171Apathy (HP:0000741)1.78960729
172Abnormality of abdominal situs (HP:0011620)1.78953811
173Abdominal situs inversus (HP:0003363)1.78953811
174Verrucae (HP:0200043)1.78587189
175Papilloma (HP:0012740)1.78587189
176Preauricular skin tag (HP:0000384)1.77384796
177Birth length less than 3rd percentile (HP:0003561)1.77013876
178Hypogonadotrophic hypogonadism (HP:0000044)1.76318048
179Poikiloderma (HP:0001029)1.74804636
180Recurrent skin infections (HP:0001581)1.74375510
181Delayed puberty (HP:0000823)1.74123703
182Syncope (HP:0001279)1.74112243
183Decreased motor nerve conduction velocity (HP:0003431)1.74110635
184Recurrent sinusitis (HP:0011108)1.73991275
185Limb hypertonia (HP:0002509)1.72987309
186Abnormality of cells of the lymphoid lineage (HP:0012140)1.72891927
187Adenoma sebaceum (HP:0009720)1.72648256
188Angiofibromas (HP:0010615)1.72648256
189Ulnar bowing (HP:0003031)1.72173320
190Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71947356
191Hyperacusis (HP:0010780)1.71884958
192Macroorchidism (HP:0000053)1.70613032
193Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69504981
194Vertebral fusion (HP:0002948)1.69498470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.37706126
2RIPK43.52220826
3MAP4K13.38675126
4PRPF4B3.30575580
5EPHA42.85911872
6GRK62.84117153
7EPHA22.81032593
8EEF2K2.67142478
9DAPK22.62534302
10MAP3K102.51250830
11CAMKK12.50206742
12STK102.49595651
13NTRK32.36525083
14PAK62.30034195
15MAP3K92.04187273
16BRD42.00195284
17MAP3K131.98098781
18ALK1.92095697
19UHMK11.89999773
20RPS6KB21.85979079
21TYRO31.84686010
22NEK21.83272966
23CAMKK21.78655537
24FLT31.66706357
25ICK1.60054617
26FES1.56542602
27MAPK121.54696180
28MAP3K111.34253451
29STK381.33481255
30BMX1.33410780
31PKN21.33052386
32CAMK11.26425828
33PRKD21.22742135
34ITK1.19448838
35TGFBR21.19060878
36CSF1R1.18233944
37CDK71.17925011
38TYK21.16907648
39SGK2231.15970451
40SGK4941.15970451
41SIK21.14004992
42MAP3K11.12917646
43SGK31.12906128
44MAP2K31.12013402
45MAPKAPK31.11167804
46PASK1.09644500
47SGK21.08932561
48KSR21.08679079
49BLK1.08620659
50PDPK11.08498560
51NEK11.08203736
52MARK11.06503761
53PNCK1.06465307
54CDC71.05717660
55EPHB11.05076522
56LRRK21.02815172
57JAK31.01047741
58ZAP700.98968445
59CDK40.98880924
60FGFR40.98624248
61HIPK20.98581203
62MTOR0.96585084
63PIM10.94700421
64CHEK10.93663552
65CSK0.91370162
66PINK10.90709477
67SYK0.89401196
68CDK50.89300836
69ARAF0.88910229
70PHKG20.85907572
71PHKG10.85907572
72TTK0.85330557
73MINK10.84708571
74MET0.83172889
75MAP3K70.81874871
76WEE10.80471153
77CHEK20.80395550
78NTRK10.79853593
79TNK20.79781277
80FGFR30.78862751
81ERN10.78452071
82PRKD30.77514111
83MATK0.76779534
84TSSK60.76716815
85CDK190.76671636
86MAP3K80.76666533
87CDK20.75926369
88CAMK1D0.74921036
89SIK10.73195497
90JAK10.71673597
91ATR0.71259129
92LCK0.71087922
93DAPK10.70436093
94BTK0.70360007
95RIPK10.70298175
96MAP3K20.69217328
97PLK10.68745360
98IRAK20.67389183
99ACVR1B0.67252806
100SGK10.66785725
101MAP3K30.66339944
102PRKCI0.66307248
103MAPK70.66120119
104SCYL20.65326597
105CAMK2B0.64829932
106MARK20.64546193
107CDC42BPA0.63949862
108FYN0.63479200
109HCK0.62693052
110NEK60.62426500
111PTK20.62286854
112CDK60.62279166
113IRAK40.61542735
114TAOK10.60927765
115JAK20.60568988
116AKT30.60217279
117TBK10.59791332
118TTN0.59751596
119TXK0.59729866
120MELK0.59579527
121MARK30.59516463
122FGR0.59502911
123SIK30.59441150
124ATM0.58208179
125DYRK30.57787757
126BMPR20.57285474
127PDK10.57136002
128PDGFRA0.56620834
129DYRK1A0.55293604
130CAMK1G0.55227855
131OBSCN0.53852988
132PRKCZ0.53564219
133PRKCQ0.53084396
134TAOK20.53064313
135PDGFRB0.52784808
136RET0.52288140
137IKBKE0.52265656
138MAP2K40.52264081
139SMG10.51617083
140CSNK1D0.51605971
141GRK50.51505328
142STK110.50933344
143PAK30.50372126
144AKT20.50081256
145PRKD10.49938211
146PTK2B0.49624414
147MAP2K60.48977990
148IKBKB0.48780890
149PRKCH0.48364376
150CAMK40.48187778
151DMPK0.47687705
152TGFBR10.47551122
153NTRK20.47317885
154WNK10.47165256
155CHUK0.46760714
156TRIB30.45641711
157CAMK2A0.45626557

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.08016277
2Mismatch repair_Homo sapiens_hsa034302.43977659
3Synaptic vesicle cycle_Homo sapiens_hsa047212.41887619
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14268105
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89467294
6Nicotine addiction_Homo sapiens_hsa050331.87607830
7Amphetamine addiction_Homo sapiens_hsa050311.86738128
8B cell receptor signaling pathway_Homo sapiens_hsa046621.86729155
9RNA transport_Homo sapiens_hsa030131.86281534
10Spliceosome_Homo sapiens_hsa030401.86160285
11mRNA surveillance pathway_Homo sapiens_hsa030151.84052423
12One carbon pool by folate_Homo sapiens_hsa006701.80940498
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77710034
14DNA replication_Homo sapiens_hsa030301.76230972
15Circadian entrainment_Homo sapiens_hsa047131.74220086
16Gastric acid secretion_Homo sapiens_hsa049711.73459968
17mTOR signaling pathway_Homo sapiens_hsa041501.69186755
18T cell receptor signaling pathway_Homo sapiens_hsa046601.66612861
19Morphine addiction_Homo sapiens_hsa050321.65659447
20Base excision repair_Homo sapiens_hsa034101.63783263
21GABAergic synapse_Homo sapiens_hsa047271.60073390
22Insulin secretion_Homo sapiens_hsa049111.60036359
23Glutamatergic synapse_Homo sapiens_hsa047241.55170236
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55126465
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48725664
26Notch signaling pathway_Homo sapiens_hsa043301.43841155
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43664542
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42815689
29Oxytocin signaling pathway_Homo sapiens_hsa049211.42114565
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39556018
31Cholinergic synapse_Homo sapiens_hsa047251.38582547
32Antigen processing and presentation_Homo sapiens_hsa046121.36656651
33Acute myeloid leukemia_Homo sapiens_hsa052211.35380210
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26897824
35Dopaminergic synapse_Homo sapiens_hsa047281.26260157
36Renin secretion_Homo sapiens_hsa049241.25088379
37Salivary secretion_Homo sapiens_hsa049701.23159015
38Fructose and mannose metabolism_Homo sapiens_hsa000511.18526761
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16583278
40Ribosome_Homo sapiens_hsa030101.16376442
41Calcium signaling pathway_Homo sapiens_hsa040201.16338234
42cAMP signaling pathway_Homo sapiens_hsa040241.15959928
43Non-homologous end-joining_Homo sapiens_hsa034501.13144773
44Cocaine addiction_Homo sapiens_hsa050301.11534506
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10415804
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.08556096
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.07900102
48Inositol phosphate metabolism_Homo sapiens_hsa005621.07543833
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07158154
50Lysine degradation_Homo sapiens_hsa003101.06321389
51VEGF signaling pathway_Homo sapiens_hsa043701.05017829
52Herpes simplex infection_Homo sapiens_hsa051681.03792501
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02816913
54Leishmaniasis_Homo sapiens_hsa051401.01650773
55Thyroid cancer_Homo sapiens_hsa052161.01017412
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00497945
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99092394
58RNA degradation_Homo sapiens_hsa030180.98962826
59Selenocompound metabolism_Homo sapiens_hsa004500.98683091
60Glioma_Homo sapiens_hsa052140.98126031
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95882493
62Nucleotide excision repair_Homo sapiens_hsa034200.95468328
63Type II diabetes mellitus_Homo sapiens_hsa049300.94775595
64HTLV-I infection_Homo sapiens_hsa051660.93204356
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93025112
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.91524430
67Tuberculosis_Homo sapiens_hsa051520.91456687
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91260196
69Nitrogen metabolism_Homo sapiens_hsa009100.90749668
70Staphylococcus aureus infection_Homo sapiens_hsa051500.90255245
71Viral carcinogenesis_Homo sapiens_hsa052030.89869760
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88963455
73Graft-versus-host disease_Homo sapiens_hsa053320.88432081
74Long-term depression_Homo sapiens_hsa047300.87958433
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87547092
76Non-small cell lung cancer_Homo sapiens_hsa052230.87399578
77Dorso-ventral axis formation_Homo sapiens_hsa043200.86993144
78Autoimmune thyroid disease_Homo sapiens_hsa053200.86348356
79Long-term potentiation_Homo sapiens_hsa047200.83552680
80Allograft rejection_Homo sapiens_hsa053300.83092124
81Pancreatic secretion_Homo sapiens_hsa049720.82536944
82Colorectal cancer_Homo sapiens_hsa052100.82495268
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.81791890
84Endocytosis_Homo sapiens_hsa041440.81084231
85p53 signaling pathway_Homo sapiens_hsa041150.79516353
86Chronic myeloid leukemia_Homo sapiens_hsa052200.78975981
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76692363
88Fanconi anemia pathway_Homo sapiens_hsa034600.76592470
89Type I diabetes mellitus_Homo sapiens_hsa049400.76535312
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.76422194
91MAPK signaling pathway_Homo sapiens_hsa040100.76189669
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.75993364
93Oocyte meiosis_Homo sapiens_hsa041140.75357202
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74991468
95Homologous recombination_Homo sapiens_hsa034400.74842563
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.73466721
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72965968
98Epstein-Barr virus infection_Homo sapiens_hsa051690.72860549
99Estrogen signaling pathway_Homo sapiens_hsa049150.72639298
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.69521678
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69484281
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69230055
103Serotonergic synapse_Homo sapiens_hsa047260.69073453
104Collecting duct acid secretion_Homo sapiens_hsa049660.68741053
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67104925
106Cell cycle_Homo sapiens_hsa041100.67055510
107Small cell lung cancer_Homo sapiens_hsa052220.66438702
108Osteoclast differentiation_Homo sapiens_hsa043800.66382740
109Biosynthesis of amino acids_Homo sapiens_hsa012300.65459872
110Melanogenesis_Homo sapiens_hsa049160.65448635
111Bile secretion_Homo sapiens_hsa049760.65309766
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.64762246
113Renal cell carcinoma_Homo sapiens_hsa052110.63734568
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63647817
115Choline metabolism in cancer_Homo sapiens_hsa052310.63253384
116Hematopoietic cell lineage_Homo sapiens_hsa046400.63077730
117Circadian rhythm_Homo sapiens_hsa047100.62998803
118HIF-1 signaling pathway_Homo sapiens_hsa040660.62952425
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62744160
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62649007
121Prion diseases_Homo sapiens_hsa050200.62563392
122Chemokine signaling pathway_Homo sapiens_hsa040620.62281924
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62186144
124Ras signaling pathway_Homo sapiens_hsa040140.62061779
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61589442
126Prolactin signaling pathway_Homo sapiens_hsa049170.61206926
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60721570
128Insulin signaling pathway_Homo sapiens_hsa049100.60717599
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.60701409
130Measles_Homo sapiens_hsa051620.60650010
131Dilated cardiomyopathy_Homo sapiens_hsa054140.60558359
132Endometrial cancer_Homo sapiens_hsa052130.60465070
133Hippo signaling pathway_Homo sapiens_hsa043900.59802820
134Histidine metabolism_Homo sapiens_hsa003400.59580626
135GnRH signaling pathway_Homo sapiens_hsa049120.59460817
136Gap junction_Homo sapiens_hsa045400.58581396
137MicroRNAs in cancer_Homo sapiens_hsa052060.58418077
138Adherens junction_Homo sapiens_hsa045200.56706373
139Platelet activation_Homo sapiens_hsa046110.56402467
140Toxoplasmosis_Homo sapiens_hsa051450.54630075
141Insulin resistance_Homo sapiens_hsa049310.54415755
142Thyroid hormone synthesis_Homo sapiens_hsa049180.54079228
143Apoptosis_Homo sapiens_hsa042100.53707685
144Rap1 signaling pathway_Homo sapiens_hsa040150.53140814
145Glucagon signaling pathway_Homo sapiens_hsa049220.53113284
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52171491
147ErbB signaling pathway_Homo sapiens_hsa040120.51938069
148Pathways in cancer_Homo sapiens_hsa052000.50540878
149African trypanosomiasis_Homo sapiens_hsa051430.50072085
150Galactose metabolism_Homo sapiens_hsa000520.49597943
151Taste transduction_Homo sapiens_hsa047420.49593625
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48710388
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48633946
154Hepatitis B_Homo sapiens_hsa051610.48192689
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47072939
156Intestinal immune network for IgA production_Homo sapiens_hsa046720.46704907
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45964152
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.45346101
159AMPK signaling pathway_Homo sapiens_hsa041520.44601790
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44567613

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