CBY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.59646872
2ATP synthesis coupled proton transport (GO:0015986)5.38173627
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.38173627
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31906771
5chaperone-mediated protein transport (GO:0072321)4.26561699
6GTP biosynthetic process (GO:0006183)3.97437873
7negative regulation of microtubule polymerization (GO:0031115)3.95478040
8neuron cell-cell adhesion (GO:0007158)3.90684273
9respiratory electron transport chain (GO:0022904)3.90546037
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.87975308
11NADH dehydrogenase complex assembly (GO:0010257)3.87975308
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87975308
13electron transport chain (GO:0022900)3.87482795
14regulation of cilium movement (GO:0003352)3.82888673
15intraciliary transport (GO:0042073)3.80756401
16protein complex biogenesis (GO:0070271)3.68250624
17protein localization to cilium (GO:0061512)3.65554396
18motile cilium assembly (GO:0044458)3.63608723
19guanosine-containing compound biosynthetic process (GO:1901070)3.53743192
20UTP biosynthetic process (GO:0006228)3.53398838
21mitochondrial respiratory chain complex assembly (GO:0033108)3.39949849
22cilium movement (GO:0003341)3.38442931
23microtubule severing (GO:0051013)3.38306438
24vocalization behavior (GO:0071625)3.36442084
25establishment of integrated proviral latency (GO:0075713)3.36293106
26purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.33336189
27protein polyglutamylation (GO:0018095)3.27648697
28synaptic vesicle exocytosis (GO:0016079)3.24888894
29purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24643440
30nonmotile primary cilium assembly (GO:0035058)3.22629019
31cullin deneddylation (GO:0010388)3.22295745
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21927044
33epithelial cilium movement (GO:0003351)3.18091198
34axonemal dynein complex assembly (GO:0070286)3.17122000
35ATP biosynthetic process (GO:0006754)3.15021422
36cilium or flagellum-dependent cell motility (GO:0001539)3.12678800
37protein deneddylation (GO:0000338)3.11985264
38protein localization to synapse (GO:0035418)3.09061997
39protein insertion into membrane (GO:0051205)3.08802682
40cilium morphogenesis (GO:0060271)3.05941034
41protein neddylation (GO:0045116)3.04838771
42nucleoside diphosphate phosphorylation (GO:0006165)3.00368519
43negative regulation of ligase activity (GO:0051352)2.99410658
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99410658
45ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98672601
46L-serine metabolic process (GO:0006563)2.97788111
47UTP metabolic process (GO:0046051)2.97536951
48* cilium organization (GO:0044782)2.96636465
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96563458
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95864498
51left/right pattern formation (GO:0060972)2.94173838
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93452878
53* cilium assembly (GO:0042384)2.93003509
54postsynaptic membrane organization (GO:0001941)2.86776302
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86492514
56CTP biosynthetic process (GO:0006241)2.85347985
57CTP metabolic process (GO:0046036)2.85347985
58axoneme assembly (GO:0035082)2.84935900
59hydrogen ion transmembrane transport (GO:1902600)2.83799902
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.82698652
61histone arginine methylation (GO:0034969)2.81822748
62pyrimidine nucleobase catabolic process (GO:0006208)2.81502587
63microtubule depolymerization (GO:0007019)2.80757584
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.80079848
65regulation of cellular amino acid metabolic process (GO:0006521)2.79983895
66aldehyde catabolic process (GO:0046185)2.75695525
67mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.75258142
68nucleoside triphosphate biosynthetic process (GO:0009142)2.74721173
697-methylguanosine mRNA capping (GO:0006370)2.74299343
70oxidative phosphorylation (GO:0006119)2.74130313
71inner mitochondrial membrane organization (GO:0007007)2.71243599
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70768008
73RNA capping (GO:0036260)2.65524691
747-methylguanosine RNA capping (GO:0009452)2.65524691
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63594495
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63209342
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63209342
78sensory perception of smell (GO:0007608)2.62905925
79establishment of viral latency (GO:0019043)2.61865220
80regulation of microtubule-based movement (GO:0060632)2.61450042
81establishment of protein localization to mitochondrion (GO:0072655)2.60780264
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.60525352
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60495041
84proteasome assembly (GO:0043248)2.60314984
85protein targeting to mitochondrion (GO:0006626)2.59439069
86regulation of synapse structural plasticity (GO:0051823)2.59424461
87ATP hydrolysis coupled proton transport (GO:0015991)2.59271243
88energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59271243
89sequestering of actin monomers (GO:0042989)2.58409737
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58396941
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58396941
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58396941
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.57931167
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57189420
95respiratory chain complex IV assembly (GO:0008535)2.56680131
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.55939906
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55314171
98termination of RNA polymerase III transcription (GO:0006386)2.54861340
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.54861340
100platelet dense granule organization (GO:0060155)2.54686534
101maturation of SSU-rRNA (GO:0030490)2.54446180
102positive regulation of ligase activity (GO:0051351)2.52996398
103positive regulation of synapse maturation (GO:0090129)2.52405458
104signal transduction involved in DNA integrity checkpoint (GO:0072401)2.50560400
105signal transduction involved in DNA damage checkpoint (GO:0072422)2.50560400
106retinal ganglion cell axon guidance (GO:0031290)2.50097190
107viral transcription (GO:0019083)2.47154762
108DNA deamination (GO:0045006)2.46096725
109regulation of ubiquitin-protein transferase activity (GO:0051438)2.46083199
110spliceosomal snRNP assembly (GO:0000387)2.45607547
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45602032
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45602032
113viral mRNA export from host cell nucleus (GO:0046784)2.42410167
114presynaptic membrane organization (GO:0097090)2.41525250
115peptidyl-arginine omega-N-methylation (GO:0035247)2.41287670
116presynaptic membrane assembly (GO:0097105)2.41139704
117DNA damage response, detection of DNA damage (GO:0042769)2.40575684
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40450341
119peptidyl-histidine modification (GO:0018202)2.40316701
120axon extension involved in axon guidance (GO:0048846)2.39140597
121neuron projection extension involved in neuron projection guidance (GO:1902284)2.39140597
122water-soluble vitamin biosynthetic process (GO:0042364)2.38369496
123regulation of mitochondrial translation (GO:0070129)2.36103736
124microtubule bundle formation (GO:0001578)2.31937820
125ubiquinone biosynthetic process (GO:0006744)2.31692037
126cytochrome complex assembly (GO:0017004)2.30134858
127ubiquinone metabolic process (GO:0006743)2.29936921
128smoothened signaling pathway (GO:0007224)2.29434140
129* cellular component assembly involved in morphogenesis (GO:0010927)2.29154488
130negative regulation of axon guidance (GO:1902668)2.28199081
131base-excision repair, AP site formation (GO:0006285)2.27444919
132left/right axis specification (GO:0070986)2.26323260
133establishment of tissue polarity (GO:0007164)2.25331141
134establishment of planar polarity (GO:0001736)2.25331141
135glutathione derivative biosynthetic process (GO:1901687)2.24793785
136glutathione derivative metabolic process (GO:1901685)2.24793785
137limb bud formation (GO:0060174)2.19390240
138resolution of meiotic recombination intermediates (GO:0000712)2.18058927
139nucleobase catabolic process (GO:0046113)2.18035942
140short-term memory (GO:0007614)2.17070594
141serine family amino acid biosynthetic process (GO:0009070)2.11906166
142negative regulation of transcription regulatory region DNA binding (GO:2000678)2.09501156
143otic vesicle formation (GO:0030916)2.09079558
144L-methionine salvage (GO:0071267)2.06496489
145L-methionine biosynthetic process (GO:0071265)2.06496489
146amino acid salvage (GO:0043102)2.06496489
147centriole replication (GO:0007099)2.06005607
148branched-chain amino acid catabolic process (GO:0009083)2.05457943
149positive regulation of mitochondrial fission (GO:0090141)2.04489060
150cochlea development (GO:0090102)2.04058703
151chromatin remodeling at centromere (GO:0031055)2.03867527
152serine family amino acid catabolic process (GO:0009071)2.03718617
153sperm motility (GO:0030317)2.02898123
154neuron fate determination (GO:0048664)2.01785772
155determination of left/right symmetry (GO:0007368)2.01478231
156sterol biosynthetic process (GO:0016126)2.00515568
157DNA integration (GO:0015074)1.97511501
158response to nitrosative stress (GO:0051409)1.96719177
159histone H2A acetylation (GO:0043968)1.96538310
160protein-cofactor linkage (GO:0018065)1.95329510
161ventricular system development (GO:0021591)1.95254385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29104541
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34486610
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17254128
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14302196
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.10530514
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97305177
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.92097944
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.86612166
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.77658318
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.71070981
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51269941
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50478469
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34665718
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28034179
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27518693
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22138508
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21013767
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20584359
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18229716
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.99675385
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97112365
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94792160
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92275689
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91735457
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87846476
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83790869
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.83485275
28XRN2_22483619_ChIP-Seq_HELA_Human1.79631542
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64051466
30CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.63625748
31EWS_26573619_Chip-Seq_HEK293_Human1.62935552
32GBX2_23144817_ChIP-Seq_PC3_Human1.61347599
33* VDR_23849224_ChIP-Seq_CD4+_Human1.60959609
34IRF1_19129219_ChIP-ChIP_H3396_Human1.59845843
35REST_21632747_ChIP-Seq_MESCs_Mouse1.58301687
36TTF2_22483619_ChIP-Seq_HELA_Human1.58273089
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.57524513
38* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.56300443
39DCP1A_22483619_ChIP-Seq_HELA_Human1.55957301
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54562324
41* GABP_19822575_ChIP-Seq_HepG2_Human1.53472816
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53412478
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53056687
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.52892091
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52533403
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52344807
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.48176433
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46446609
49SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45690447
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43329240
51P300_19829295_ChIP-Seq_ESCs_Human1.43235460
52TAF15_26573619_Chip-Seq_HEK293_Human1.41755769
53* FOXP3_21729870_ChIP-Seq_TREG_Human1.39109373
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35947455
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35268812
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34603640
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33046382
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32164140
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.30869307
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30474985
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30233453
62IGF1R_20145208_ChIP-Seq_DFB_Human1.25985216
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25506456
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23276264
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22454522
66VDR_22108803_ChIP-Seq_LS180_Human1.21940768
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21720882
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20869078
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19858236
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19795555
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19545162
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18539741
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16957461
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.16728697
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13351191
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12804951
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.12804197
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12391925
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11711026
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11690880
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08824248
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06153430
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06153430
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06138869
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.05964985
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05568893
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04551298
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03913830
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03568111
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.03165863
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02709746
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02671970
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02609810
94RNF2_27304074_Chip-Seq_NSC_Mouse1.02449664
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02325699
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01941394
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01933237
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01389807
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00341451
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99700046
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99573720
102SMAD4_21799915_ChIP-Seq_A2780_Human0.99455592
103TRIM28_21343339_ChIP-Seq_HEK293_Human0.99113558
104SMAD3_21741376_ChIP-Seq_EPCs_Human0.98841103
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.98638623
106ZNF274_21170338_ChIP-Seq_K562_Hela0.97967350
107ELK1_19687146_ChIP-ChIP_HELA_Human0.97961152
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97307508
109CBP_20019798_ChIP-Seq_JUKART_Human0.96339562
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96339562
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96193426
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96050134
113EOMES_21245162_ChIP-Seq_HESCs_Human0.95885129
114MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95371648
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95166595
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95116448
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94535568
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94484301
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94294149
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94078327
121FUS_26573619_Chip-Seq_HEK293_Human0.92580094
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.91254452
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90324155
124* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90278543
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89728238
126TP53_22573176_ChIP-Seq_HFKS_Human0.87929749
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87279174
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85698460
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85689406
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85453019
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.85356537
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85259386
133BCAT_22108803_ChIP-Seq_LS180_Human0.85053967
134AR_25329375_ChIP-Seq_VCAP_Human0.84824212
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.84664742
136RUNX2_22187159_ChIP-Seq_PCA_Human0.84514655
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84441326
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84188387
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.83093014
140PHF8_20622853_ChIP-Seq_HELA_Human0.82355368
141HTT_18923047_ChIP-ChIP_STHdh_Human0.82299469
142MYC_18940864_ChIP-ChIP_HL60_Human0.82254211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.50687920
2MP0004859_abnormal_synaptic_plasticity3.39577980
3MP0001984_abnormal_olfaction3.12217090
4MP0008789_abnormal_olfactory_epithelium2.88780555
5MP0001529_abnormal_vocalization2.80794594
6MP0005394_taste/olfaction_phenotype2.62468963
7MP0005499_abnormal_olfactory_system2.62468963
8MP0003136_yellow_coat_color2.61200944
9MP0003635_abnormal_synaptic_transmissio2.55941081
10MP0004270_analgesia2.53241242
11MP0006276_abnormal_autonomic_nervous2.43480419
12MP0002653_abnormal_ependyma_morphology2.25804454
13MP0010030_abnormal_orbit_morphology2.19617458
14MP0002063_abnormal_learning/memory/cond2.11647506
15MP0001968_abnormal_touch/_nociception2.10849474
16MP0002102_abnormal_ear_morphology2.09302096
17MP0002736_abnormal_nociception_after2.07317912
18MP0000778_abnormal_nervous_system2.06427588
19MP0009745_abnormal_behavioral_response2.06371852
20MP0002734_abnormal_mechanical_nocicepti2.05627939
21MP0005423_abnormal_somatic_nervous2.00144343
22MP0002184_abnormal_innervation1.96142180
23MP0002234_abnormal_pharynx_morphology1.94561093
24MP0008877_abnormal_DNA_methylation1.93635726
25MP0002572_abnormal_emotion/affect_behav1.90446132
26MP0005410_abnormal_fertilization1.90442284
27MP0002064_seizures1.89458966
28MP0005645_abnormal_hypothalamus_physiol1.87333459
29MP0002272_abnormal_nervous_system1.82141829
30MP0001905_abnormal_dopamine_level1.80969413
31MP0005646_abnormal_pituitary_gland1.73010922
32MP0009046_muscle_twitch1.71086074
33MP0002638_abnormal_pupillary_reflex1.69546523
34MP0002735_abnormal_chemical_nociception1.69136516
35MP0001440_abnormal_grooming_behavior1.61504145
36MP0002233_abnormal_nose_morphology1.61503057
37MP0002557_abnormal_social/conspecific_i1.61319442
38MP0002160_abnormal_reproductive_system1.59704590
39MP0000566_synostosis1.55852063
40MP0002751_abnormal_autonomic_nervous1.50997430
41MP0003787_abnormal_imprinting1.47613013
42MP0003122_maternal_imprinting1.47039352
43MP0001188_hyperpigmentation1.46981820
44MP0006292_abnormal_olfactory_placode1.44665385
45MP0004811_abnormal_neuron_physiology1.44373948
46MP0002733_abnormal_thermal_nociception1.40561146
47MP0004142_abnormal_muscle_tone1.40423278
48MP0000631_abnormal_neuroendocrine_gland1.39361241
49MP0002282_abnormal_trachea_morphology1.38828796
50MP0001486_abnormal_startle_reflex1.38143127
51MP0001293_anophthalmia1.38073252
52MP0002067_abnormal_sensory_capabilities1.37276673
53MP0004133_heterotaxia1.36765728
54MP0002882_abnormal_neuron_morphology1.36623268
55MP0001970_abnormal_pain_threshold1.36364162
56MP0009379_abnormal_foot_pigmentation1.36110483
57MP0005084_abnormal_gallbladder_morpholo1.35891125
58MP0002837_dystrophic_cardiac_calcinosis1.35409150
59MP0003186_abnormal_redox_activity1.32779218
60MP0003937_abnormal_limbs/digits/tail_de1.29319836
61MP0000955_abnormal_spinal_cord1.29062764
62MP0003718_maternal_effect1.25055593
63MP0001485_abnormal_pinna_reflex1.24432091
64MP0003693_abnormal_embryo_hatching1.24099299
65MP0002752_abnormal_somatic_nervous1.22788370
66* MP0003698_abnormal_male_reproductive1.22519167
67MP0002152_abnormal_brain_morphology1.21584742
68MP0000372_irregular_coat_pigmentation1.19749638
69MP0003119_abnormal_digestive_system1.18613661
70MP0006072_abnormal_retinal_apoptosis1.17259416
71MP0003121_genomic_imprinting1.17257158
72MP0003879_abnormal_hair_cell1.15153982
73MP0003861_abnormal_nervous_system1.13802199
74MP0002822_catalepsy1.12239655
75MP0008875_abnormal_xenobiotic_pharmacok1.11471210
76MP0003755_abnormal_palate_morphology1.11270111
77MP0003011_delayed_dark_adaptation1.11197016
78MP0003283_abnormal_digestive_organ1.10581262
79MP0000516_abnormal_urinary_system1.05683722
80MP0005367_renal/urinary_system_phenotyp1.05683722
81MP0000026_abnormal_inner_ear1.05124891
82MP0006035_abnormal_mitochondrial_morpho1.04563730
83MP0002163_abnormal_gland_morphology1.04499955
84MP0002066_abnormal_motor_capabilities/c1.04301543
85MP0001986_abnormal_taste_sensitivity1.03578724
86MP0003315_abnormal_perineum_morphology1.03430950
87MP0010386_abnormal_urinary_bladder1.00964175
88MP0005551_abnormal_eye_electrophysiolog1.00879427
89MP0005386_behavior/neurological_phenoty1.00698372
90MP0004924_abnormal_behavior1.00698372
91MP0008058_abnormal_DNA_repair1.00601336
92MP0001299_abnormal_eye_distance/0.98981739
93MP0001929_abnormal_gametogenesis0.97661713
94MP0000049_abnormal_middle_ear0.96495437
95MP0005503_abnormal_tendon_morphology0.94876566
96MP0004957_abnormal_blastocyst_morpholog0.94482335
97MP0004858_abnormal_nervous_system0.94408641
98MP0001963_abnormal_hearing_physiology0.94201429
99MP0008932_abnormal_embryonic_tissue0.93765893
100MP0003938_abnormal_ear_development0.93263255
101MP0001286_abnormal_eye_development0.92826384
102MP0004742_abnormal_vestibular_system0.92748173
103MP0003806_abnormal_nucleotide_metabolis0.91490033
104MP0004885_abnormal_endolymph0.91477039
105MP0010094_abnormal_chromosome_stability0.90273065
106MP0009780_abnormal_chondrocyte_physiolo0.90172957
107MP0002090_abnormal_vision0.88991030
108MP0005389_reproductive_system_phenotype0.88883503
109MP0002249_abnormal_larynx_morphology0.88493502
110MP0000751_myopathy0.88072044
111MP0003890_abnormal_embryonic-extraembry0.87741191
112MP0005391_vision/eye_phenotype0.86204901
113MP0000537_abnormal_urethra_morphology0.86170374
114MP0003942_abnormal_urinary_system0.85975033
115MP0005171_absent_coat_pigmentation0.85515861
116MP0000762_abnormal_tongue_morphology0.84695116
117MP0002697_abnormal_eye_size0.84682385
118MP0002938_white_spotting0.84424513
119MP0002210_abnormal_sex_determination0.83749281
120MP0008569_lethality_at_weaning0.83128392
121MP0005195_abnormal_posterior_eye0.82267931
122MP0005253_abnormal_eye_physiology0.81790824
123MP0003123_paternal_imprinting0.79108282
124MP0009250_abnormal_appendicular_skeleto0.77697694
125MP0004215_abnormal_myocardial_fiber0.77682090
126MP0003941_abnormal_skin_development0.77085010
127MP0010368_abnormal_lymphatic_system0.77070512
128MP0001501_abnormal_sleep_pattern0.76569369
129MP0002909_abnormal_adrenal_gland0.76315166
130MP0006036_abnormal_mitochondrial_physio0.75141442
131MP0005623_abnormal_meninges_morphology0.75025430
132MP0003077_abnormal_cell_cycle0.74865360
133MP0001324_abnormal_eye_pigmentation0.74531372
134MP0009697_abnormal_copulation0.74239115
135MP0003195_calcinosis0.74028468
136* MP0002161_abnormal_fertility/fecundity0.73967961
137MP0003137_abnormal_impulse_conducting0.73759391
138MP0009384_cardiac_valve_regurgitation0.72820710
139MP0002229_neurodegeneration0.72752760
140MP0002116_abnormal_craniofacial_bone0.72423289
141MP0005379_endocrine/exocrine_gland_phen0.71718469
142MP0001145_abnormal_male_reproductive0.71447960
143MP0004085_abnormal_heartbeat0.71379455

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.50730602
2Abnormal mitochondria in muscle tissue (HP:0008316)5.09179426
3Progressive macrocephaly (HP:0004481)4.59372750
4Mitochondrial inheritance (HP:0001427)4.45439118
5Acute encephalopathy (HP:0006846)4.24208157
6Abnormal respiratory motile cilium physiology (HP:0012261)4.08351674
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08340797
8Abnormal respiratory epithelium morphology (HP:0012253)3.88560756
9Abnormal respiratory motile cilium morphology (HP:0005938)3.88560756
10Myokymia (HP:0002411)3.85894439
11Abnormal ciliary motility (HP:0012262)3.84777016
12Increased CSF lactate (HP:0002490)3.80849044
13Hepatocellular necrosis (HP:0001404)3.60839216
14Gait imbalance (HP:0002141)3.50799078
15Medial flaring of the eyebrow (HP:0010747)3.43965465
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.36479890
17Absent/shortened dynein arms (HP:0200106)3.36479890
18Rhinitis (HP:0012384)3.31438431
19Congenital primary aphakia (HP:0007707)3.28391376
20Increased serum pyruvate (HP:0003542)3.28179290
21Abnormality of glycolysis (HP:0004366)3.28179290
22Occipital encephalocele (HP:0002085)3.26820619
23Nephrogenic diabetes insipidus (HP:0009806)3.11916894
24Increased hepatocellular lipid droplets (HP:0006565)3.08604642
25Atonic seizures (HP:0010819)3.03965094
26Optic disc pallor (HP:0000543)2.94945021
27Leukodystrophy (HP:0002415)2.87171137
28Focal motor seizures (HP:0011153)2.85537316
29Hypothermia (HP:0002045)2.84858364
30Exercise intolerance (HP:0003546)2.83301556
31Vaginal atresia (HP:0000148)2.70190097
32Hepatic necrosis (HP:0002605)2.68614057
33Genital tract atresia (HP:0001827)2.67785916
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67694261
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67694261
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.62317757
37Lipid accumulation in hepatocytes (HP:0006561)2.60913149
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57770198
39Tubulointerstitial nephritis (HP:0001970)2.57020069
40Cystic liver disease (HP:0006706)2.56055424
41Bronchiectasis (HP:0002110)2.54101421
42Respiratory failure (HP:0002878)2.52893626
43Pancreatic fibrosis (HP:0100732)2.51743214
44Limb dystonia (HP:0002451)2.48739007
45Neuroendocrine neoplasm (HP:0100634)2.48660003
46Renal Fanconi syndrome (HP:0001994)2.48401592
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45301319
48Postaxial foot polydactyly (HP:0001830)2.44118720
49Increased serum lactate (HP:0002151)2.41082831
50Pheochromocytoma (HP:0002666)2.41004249
51Abnormality of dentin (HP:0010299)2.40813100
52Increased intramyocellular lipid droplets (HP:0012240)2.40702024
53Nephronophthisis (HP:0000090)2.40238051
54Cerebral edema (HP:0002181)2.37230083
55Lactic acidosis (HP:0003128)2.32893357
56Poor coordination (HP:0002370)2.32050110
57Abnormality of the renal medulla (HP:0100957)2.31798928
58Abnormality of cells of the erythroid lineage (HP:0012130)2.29962257
59Bifid tongue (HP:0010297)2.29464722
60Abnormality of midbrain morphology (HP:0002418)2.28255946
61Molar tooth sign on MRI (HP:0002419)2.28255946
62Chronic bronchitis (HP:0004469)2.23909189
63Epileptic encephalopathy (HP:0200134)2.23847404
64True hermaphroditism (HP:0010459)2.22144854
65Male pseudohermaphroditism (HP:0000037)2.14054656
66Hyperglycinemia (HP:0002154)2.13790475
67Abnormal hair whorl (HP:0010721)2.10416091
68Abnormal number of erythroid precursors (HP:0012131)2.09055490
69Focal seizures (HP:0007359)2.05866222
70Cerebral hypomyelination (HP:0006808)2.02303229
71Emotional lability (HP:0000712)2.02084210
72Retinal dysplasia (HP:0007973)2.01011981
73Aplasia/Hypoplasia of the lens (HP:0008063)2.00044791
74Methylmalonic acidemia (HP:0002912)1.99931498
75Abnormality of the labia minora (HP:0012880)1.99270952
76Progressive cerebellar ataxia (HP:0002073)1.99152764
77Respiratory difficulties (HP:0002880)1.97897127
78Unsteady gait (HP:0002317)1.96993035
79Febrile seizures (HP:0002373)1.96314763
80Chronic hepatic failure (HP:0100626)1.93635450
81Delusions (HP:0000746)1.93374700
82Postaxial hand polydactyly (HP:0001162)1.93262676
83Absence seizures (HP:0002121)1.91803230
84Congenital hepatic fibrosis (HP:0002612)1.91011123
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89505180
86Hypoplasia of the brainstem (HP:0002365)1.89505180
87Aplasia/hypoplasia of the uterus (HP:0008684)1.88872287
88Sclerocornea (HP:0000647)1.88214771
89Visual hallucinations (HP:0002367)1.87443519
90Pancreatic cysts (HP:0001737)1.86733807
91Infertility (HP:0000789)1.85084666
92Increased muscle lipid content (HP:0009058)1.83945118
933-Methylglutaconic aciduria (HP:0003535)1.83807109
94Specific learning disability (HP:0001328)1.82674137
95Anophthalmia (HP:0000528)1.82526279
96Septo-optic dysplasia (HP:0100842)1.82348681
97Amblyopia (HP:0000646)1.82051477
98Methylmalonic aciduria (HP:0012120)1.81210023
99X-linked dominant inheritance (HP:0001423)1.80575435
100Facial cleft (HP:0002006)1.77585873
101Broad foot (HP:0001769)1.77050205
102Exertional dyspnea (HP:0002875)1.76728909
103Polyphagia (HP:0002591)1.74351630
104Hyperventilation (HP:0002883)1.72303202
105Supernumerary spleens (HP:0009799)1.71507230
106Lissencephaly (HP:0001339)1.66707507
107Rimmed vacuoles (HP:0003805)1.66457369
108Hypoplastic left heart (HP:0004383)1.64417319
109Abnormality of renal resorption (HP:0011038)1.63997532
110Poor suck (HP:0002033)1.63747350
111Aganglionic megacolon (HP:0002251)1.63576309
112Delayed gross motor development (HP:0002194)1.63206545
113Anencephaly (HP:0002323)1.62529932
114Glycosuria (HP:0003076)1.61790987
115Abnormality of urine glucose concentration (HP:0011016)1.61790987
116Dialeptic seizures (HP:0011146)1.61402792
117Severe visual impairment (HP:0001141)1.61180788
118Renal dysplasia (HP:0000110)1.60304859
119Colon cancer (HP:0003003)1.59944985
120Hypoplastic pelvis (HP:0008839)1.59922409
121Oculomotor apraxia (HP:0000657)1.59328166
122Preaxial hand polydactyly (HP:0001177)1.59084271
123Renal hypoplasia (HP:0000089)1.58559256
124Median cleft lip (HP:0000161)1.58318715
125Decreased testicular size (HP:0008734)1.57765638
126Narrow forehead (HP:0000341)1.57448953
127Male infertility (HP:0003251)1.55900187
128Abnormal biliary tract physiology (HP:0012439)1.54811764
129Bile duct proliferation (HP:0001408)1.54811764
130Sensory axonal neuropathy (HP:0003390)1.54144786
131Furrowed tongue (HP:0000221)1.53895461
132Tubulointerstitial abnormality (HP:0001969)1.52750295
133Lethargy (HP:0001254)1.51700943
134Multicystic kidney dysplasia (HP:0000003)1.47252920
135Type I transferrin isoform profile (HP:0003642)1.46472871
136Chorioretinal coloboma (HP:0000567)1.46090409
137Short tibia (HP:0005736)1.45732891
138Optic nerve hypoplasia (HP:0000609)1.45453232
139Maternal diabetes (HP:0009800)1.44816395
140Congenital malformation of the right heart (HP:0011723)1.43996908
141Double outlet right ventricle (HP:0001719)1.43996908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.84832673
2CASK3.31812639
3VRK23.13663566
4MAPK153.06904543
5STK162.95542340
6ARAF2.85756038
7MARK12.62096955
8MAP3K122.55548389
9EPHB22.51548419
10MAP2K72.17107352
11MAP3K42.09236869
12NTRK22.06801352
13MAPK132.02807194
14PDK41.96565563
15PDK31.96565563
16CCNB11.91228154
17BCKDK1.89526297
18BRAF1.86626298
19NME11.80228796
20DYRK21.75805106
21MINK11.73949127
22PBK1.73930435
23TESK11.67520584
24WEE11.65807905
25DAPK11.63833560
26PINK11.62127804
27ERBB31.59648962
28NUAK11.59107454
29LIMK11.58669136
30MST41.57087647
31CDK191.55277421
32PNCK1.52673425
33BCR1.49275929
34STK38L1.48684212
35TESK21.45429010
36EPHA41.44889898
37UHMK11.40547336
38PLK21.38683484
39CSNK1G11.35681542
40BMPR21.31777906
41TRIM281.30451023
42DAPK21.25530103
43MAP4K21.24442275
44DYRK31.22131047
45BRSK11.20229738
46FRK1.20216972
47TTK1.15051459
48SRPK11.13012349
49AURKA1.11941954
50TSSK61.10826373
51SIK31.09225130
52VRK11.08711040
53PHKG11.06290805
54PHKG21.06290805
55CDK181.05913421
56CDK141.05454795
57NTRK31.04206258
58MAP3K91.03405840
59PLK41.02894454
60PRKCG1.02217524
61GRK51.00961474
62CAMKK21.00606174
63TAF11.00290610
64MYLK0.99744870
65TNIK0.99085067
66CDK150.98719705
67CSNK1G30.98506955
68WNK30.97126413
69BRSK20.94295044
70PLK30.94264301
71INSRR0.93990391
72CDK11A0.92626146
73AKT30.92140171
74ZAK0.90258903
75PIM20.90218043
76ADRBK20.87500941
77PAK30.84107288
78TIE10.83997118
79PDK20.83094534
80DAPK30.82970381
81GRK10.82367513
82ILK0.80786288
83CAMK2B0.80719331
84PLK10.80184485
85KSR10.79821717
86EPHA20.79276742
87MAPKAPK50.79275221
88NTRK10.76759227
89NEK10.74911290
90ADRBK10.73787212
91CDK50.73510538
92CSNK1G20.72182827
93PRKCE0.71773692
94PTK2B0.69617760
95LATS10.69022509
96PRKCI0.67220169
97STK390.67191188
98ICK0.64990807
99TLK10.64835151
100NEK20.62695386
101MUSK0.61835064
102MAP2K40.60928735
103PRKD30.60852602
104ROCK20.59934548
105CAMK2A0.59856331
106LMTK20.59127963
107STK240.58791417
108PAK10.56529684
109PAK60.53426013
110CHEK20.52385934
111MKNK20.52316874
112NME20.51340954
113RPS6KA40.49488791
114RPS6KA20.47402737
115CDC70.46941747
116WNK40.46676692
117MET0.46524783
118OBSCN0.46346626
119OXSR10.46076915
120EIF2AK10.44157005
121DYRK1A0.44029521
122PASK0.43559811
123STK30.42859738
124ABL20.42808712
125AURKB0.42744186
126CDK30.42620800
127SGK4940.41797871
128SGK2230.41797871
129CSNK1A10.41750256
130LATS20.41311243
131MKNK10.40574310
132BMPR1B0.39947465
133MAPKAPK30.39315266
134GRK60.37629167
135CAMK2D0.36157917
136CSNK1A1L0.36018664
137YES10.35276233
138ACVR1B0.34721511
139GRK70.34498346

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.45193269
2Parkinsons disease_Homo sapiens_hsa050124.02220800
3Proteasome_Homo sapiens_hsa030503.70537230
4Huntingtons disease_Homo sapiens_hsa050163.25489070
5Alzheimers disease_Homo sapiens_hsa050102.99266006
6Ribosome_Homo sapiens_hsa030102.87863520
7Synaptic vesicle cycle_Homo sapiens_hsa047212.45172083
8Cardiac muscle contraction_Homo sapiens_hsa042602.36169057
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35629970
10RNA polymerase_Homo sapiens_hsa030202.35038198
11Olfactory transduction_Homo sapiens_hsa047402.28691085
12Collecting duct acid secretion_Homo sapiens_hsa049662.10425339
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03511992
14Nicotine addiction_Homo sapiens_hsa050332.00846320
15Propanoate metabolism_Homo sapiens_hsa006401.95304728
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86850093
17Spliceosome_Homo sapiens_hsa030401.84930659
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77357168
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76566344
20Butanoate metabolism_Homo sapiens_hsa006501.74942402
21Phototransduction_Homo sapiens_hsa047441.70959660
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59504308
23Mismatch repair_Homo sapiens_hsa034301.53023392
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50005260
25Steroid biosynthesis_Homo sapiens_hsa001001.49125010
26Peroxisome_Homo sapiens_hsa041461.47657071
27Vibrio cholerae infection_Homo sapiens_hsa051101.47526721
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45957510
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44836392
30DNA replication_Homo sapiens_hsa030301.44835662
31Protein export_Homo sapiens_hsa030601.44828411
32Dopaminergic synapse_Homo sapiens_hsa047281.37921975
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37915945
34Oocyte meiosis_Homo sapiens_hsa041141.37888129
35Pyrimidine metabolism_Homo sapiens_hsa002401.34930994
36Nucleotide excision repair_Homo sapiens_hsa034201.31516962
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.29643641
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29500524
39Sulfur relay system_Homo sapiens_hsa041221.28549247
40Circadian entrainment_Homo sapiens_hsa047131.26189807
41Basal transcription factors_Homo sapiens_hsa030221.24926237
42beta-Alanine metabolism_Homo sapiens_hsa004101.24634612
43Amphetamine addiction_Homo sapiens_hsa050311.24604615
44GABAergic synapse_Homo sapiens_hsa047271.23558882
45Folate biosynthesis_Homo sapiens_hsa007901.23414124
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22194541
47Chemical carcinogenesis_Homo sapiens_hsa052041.21292117
48Long-term potentiation_Homo sapiens_hsa047201.19610794
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18891164
50RNA transport_Homo sapiens_hsa030131.17539565
51Glutamatergic synapse_Homo sapiens_hsa047241.16366095
52Purine metabolism_Homo sapiens_hsa002301.14794643
53Taste transduction_Homo sapiens_hsa047421.14316790
54Morphine addiction_Homo sapiens_hsa050321.13939164
55Base excision repair_Homo sapiens_hsa034101.13771101
56Serotonergic synapse_Homo sapiens_hsa047261.13713958
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11106396
58Pyruvate metabolism_Homo sapiens_hsa006201.07782346
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06478572
60Homologous recombination_Homo sapiens_hsa034401.03599215
61Alcoholism_Homo sapiens_hsa050340.99476276
62Arginine and proline metabolism_Homo sapiens_hsa003300.97454082
63Fatty acid degradation_Homo sapiens_hsa000710.96698203
64Cell cycle_Homo sapiens_hsa041100.95940459
65Sulfur metabolism_Homo sapiens_hsa009200.95799153
66Phenylalanine metabolism_Homo sapiens_hsa003600.93256621
67Retinol metabolism_Homo sapiens_hsa008300.92773212
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.90521191
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88701344
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87315772
71mRNA surveillance pathway_Homo sapiens_hsa030150.85571870
72Tyrosine metabolism_Homo sapiens_hsa003500.84274830
73Cholinergic synapse_Homo sapiens_hsa047250.82217453
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79286981
75Gap junction_Homo sapiens_hsa045400.78906748
76RNA degradation_Homo sapiens_hsa030180.77877389
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76827103
78Fatty acid metabolism_Homo sapiens_hsa012120.76253812
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76218103
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75828352
81Calcium signaling pathway_Homo sapiens_hsa040200.75036351
82Axon guidance_Homo sapiens_hsa043600.73245495
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71040383
84Fanconi anemia pathway_Homo sapiens_hsa034600.69335114
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68874296
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68373937
87Hippo signaling pathway_Homo sapiens_hsa043900.68077404
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66977689
89Insulin secretion_Homo sapiens_hsa049110.66269067
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65772533
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.65149053
92Nitrogen metabolism_Homo sapiens_hsa009100.61098063
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59632311
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58987490
95Caffeine metabolism_Homo sapiens_hsa002320.58769705
96Melanogenesis_Homo sapiens_hsa049160.58682665
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58344929
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58224518
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57878241
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56731668
101One carbon pool by folate_Homo sapiens_hsa006700.56588167
102Vitamin B6 metabolism_Homo sapiens_hsa007500.56257789
103Cocaine addiction_Homo sapiens_hsa050300.56153755
104Long-term depression_Homo sapiens_hsa047300.55625495
105Histidine metabolism_Homo sapiens_hsa003400.55059494
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55016735
107Oxytocin signaling pathway_Homo sapiens_hsa049210.54424982
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54397094
109Tryptophan metabolism_Homo sapiens_hsa003800.53456027
110Salivary secretion_Homo sapiens_hsa049700.52486562
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52211364
112Selenocompound metabolism_Homo sapiens_hsa004500.50545398
113Hedgehog signaling pathway_Homo sapiens_hsa043400.50396216
114Tight junction_Homo sapiens_hsa045300.49980926
115Non-homologous end-joining_Homo sapiens_hsa034500.48694328
116Gastric acid secretion_Homo sapiens_hsa049710.47610381
117Renin secretion_Homo sapiens_hsa049240.46106690
118Carbon metabolism_Homo sapiens_hsa012000.44661785
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44413599
120Arginine biosynthesis_Homo sapiens_hsa002200.44304905
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42334600
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42142024
123Epstein-Barr virus infection_Homo sapiens_hsa051690.41699342
124Metabolic pathways_Homo sapiens_hsa011000.41430268
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40290095
126Basal cell carcinoma_Homo sapiens_hsa052170.38532711
127Colorectal cancer_Homo sapiens_hsa052100.37107566
128N-Glycan biosynthesis_Homo sapiens_hsa005100.36903331
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34954372
130Wnt signaling pathway_Homo sapiens_hsa043100.34831196
131Phagosome_Homo sapiens_hsa041450.32506763
132Regulation of autophagy_Homo sapiens_hsa041400.31478191
133GnRH signaling pathway_Homo sapiens_hsa049120.30781785
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28634513
135Systemic lupus erythematosus_Homo sapiens_hsa053220.28509108
136Glucagon signaling pathway_Homo sapiens_hsa049220.28245954
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.24589801
138Fructose and mannose metabolism_Homo sapiens_hsa000510.24472581
139Biosynthesis of amino acids_Homo sapiens_hsa012300.23420603
140Glutathione metabolism_Homo sapiens_hsa004800.23379357
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.22936844
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20646016
143Pentose phosphate pathway_Homo sapiens_hsa000300.18766042
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18111916
145Fatty acid elongation_Homo sapiens_hsa000620.17803513
146Glioma_Homo sapiens_hsa052140.17703414

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