CBY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.24175692
2sperm-egg recognition (GO:0035036)9.12090632
3acrosome assembly (GO:0001675)8.91061884
4spermatid development (GO:0007286)8.65003656
5axonemal dynein complex assembly (GO:0070286)8.54269602
6binding of sperm to zona pellucida (GO:0007339)8.50568552
7motile cilium assembly (GO:0044458)8.43362619
8cell-cell recognition (GO:0009988)8.10506567
9multicellular organism reproduction (GO:0032504)7.72733510
10epithelial cilium movement (GO:0003351)7.53422643
11regulation of cilium movement (GO:0003352)7.50732029
12negative regulation of inclusion body assembly (GO:0090084)7.48471646
13chromosome condensation (GO:0030261)7.12667246
14plasma membrane fusion (GO:0045026)7.02473766
15reproduction (GO:0000003)6.97731514
16microtubule depolymerization (GO:0007019)6.94611552
17synaptonemal complex assembly (GO:0007130)6.61311090
18spermatogenesis (GO:0007283)6.61223713
19male gamete generation (GO:0048232)6.58498554
20DNA packaging (GO:0006323)6.50227689
21synaptonemal complex organization (GO:0070193)6.50101914
22organic cation transport (GO:0015695)6.34012716
23male meiosis (GO:0007140)6.31564975
24cilium movement (GO:0003341)6.24025800
25gamete generation (GO:0007276)6.19366170
26regulation of inclusion body assembly (GO:0090083)5.95978502
27piRNA metabolic process (GO:0034587)5.77718656
28single fertilization (GO:0007338)5.62520029
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.60243425
30sperm capacitation (GO:0048240)5.53023783
31calcium ion-dependent exocytosis (GO:0017156)5.47110695
32rRNA methylation (GO:0031167)5.45453978
33spermatid nucleus differentiation (GO:0007289)5.15415658
34microtubule severing (GO:0051013)5.06334056
35fertilization (GO:0009566)4.98862000
36cilium or flagellum-dependent cell motility (GO:0001539)4.86858512
37multicellular organismal reproductive process (GO:0048609)4.81848087
38histone H3-K9 demethylation (GO:0033169)4.78822701
39nuclear pore complex assembly (GO:0051292)4.74060290
40snRNA metabolic process (GO:0016073)4.70280219
41snRNA processing (GO:0016180)4.69863615
42glycerol ether metabolic process (GO:0006662)4.69146049
43germ cell development (GO:0007281)4.68363065
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.65539236
45synapsis (GO:0007129)4.64710922
46positive regulation of mitochondrial fission (GO:0090141)4.63184652
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.59180803
48rRNA modification (GO:0000154)4.54598618
49male meiosis I (GO:0007141)4.47612884
50regulation of microtubule-based movement (GO:0060632)4.43886384
51sexual reproduction (GO:0019953)4.35224526
52protein targeting to Golgi (GO:0000042)4.33068597
53ether metabolic process (GO:0018904)4.30330313
54DNA synthesis involved in DNA repair (GO:0000731)4.22280534
55regulation of centriole replication (GO:0046599)4.18495206
56nuclear pore organization (GO:0006999)4.13901693
57phosphatidylethanolamine metabolic process (GO:0046337)4.12278958
58cell recognition (GO:0008037)4.10803001
59establishment of protein localization to Golgi (GO:0072600)4.09221040
60peptidyl-arginine omega-N-methylation (GO:0035247)4.08090896
61DNA ligation (GO:0006266)4.07492706
62left/right pattern formation (GO:0060972)4.07325764
63RNA destabilization (GO:0050779)4.06076632
64retrograde transport, vesicle recycling within Golgi (GO:0000301)4.06011643
65negative regulation of cAMP-mediated signaling (GO:0043951)4.05814665
66chromosome organization involved in meiosis (GO:0070192)4.00959902
67reciprocal DNA recombination (GO:0035825)3.94602325
68reciprocal meiotic recombination (GO:0007131)3.94602325
69regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.94403950
70meiosis I (GO:0007127)3.92973403
71centriole replication (GO:0007099)3.92712038
72meiotic nuclear division (GO:0007126)3.92149884
73single strand break repair (GO:0000012)3.88148282
74microtubule polymerization or depolymerization (GO:0031109)3.86704247
75multicellular organismal development (GO:0007275)3.77044598
76ventricular system development (GO:0021591)3.76157965
77mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.75572580
78polyamine biosynthetic process (GO:0006596)3.73479833
79histone exchange (GO:0043486)3.67869431
80seminiferous tubule development (GO:0072520)3.67227252
81protein-DNA complex disassembly (GO:0032986)3.64278218
82nucleosome disassembly (GO:0006337)3.64278218
83DNA methylation involved in gamete generation (GO:0043046)3.64220299
84sister chromatid cohesion (GO:0007062)3.57525708
85peptidyl-arginine N-methylation (GO:0035246)3.54198192
86peptidyl-arginine methylation (GO:0018216)3.54198192
87mitotic sister chromatid cohesion (GO:0007064)3.51602975
88peptidyl-histidine modification (GO:0018202)3.47072104
89protein polyglutamylation (GO:0018095)3.40878541
90cellular ketone body metabolic process (GO:0046950)3.38950757
91pore complex assembly (GO:0046931)3.37781432
92histone H2A acetylation (GO:0043968)3.36361087
93meiotic chromosome segregation (GO:0045132)3.34567554
94microtubule nucleation (GO:0007020)3.32332585
95regulation of mitochondrial fission (GO:0090140)3.31047890
96meiotic cell cycle (GO:0051321)3.30283399
97DNA conformation change (GO:0071103)3.26126886
98ATP-dependent chromatin remodeling (GO:0043044)3.14643157
99protein localization to Golgi apparatus (GO:0034067)3.14628523
100histone H3-K36 demethylation (GO:0070544)3.12829198
101somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06188343
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.06188343
103spliceosomal tri-snRNP complex assembly (GO:0000244)3.05231635
104regulation of spindle checkpoint (GO:0090231)3.04040299
105chaperone-mediated protein complex assembly (GO:0051131)3.03805366
106mitochondrion degradation (GO:0000422)3.02202499
107RNA localization (GO:0006403)3.02150450
108histone lysine demethylation (GO:0070076)3.01070218
109negative regulation of histone methylation (GO:0031061)2.95798008
110histone arginine methylation (GO:0034969)2.95599202
111V(D)J recombination (GO:0033151)2.95445792
112meiotic cell cycle process (GO:1903046)2.93692371
113relaxation of smooth muscle (GO:0044557)2.93148304
114glycolytic process (GO:0006096)2.93095803
115peptidyl-lysine dimethylation (GO:0018027)2.92339267
116ketone body metabolic process (GO:1902224)2.89952356
117monoubiquitinated protein deubiquitination (GO:0035520)2.87435498
118DNA strand renaturation (GO:0000733)2.87201865
119histone demethylation (GO:0016577)2.85243306
120mRNA cleavage (GO:0006379)2.84155347
121nucleus organization (GO:0006997)2.82326655
122mitochondrial fusion (GO:0008053)2.81747093
123sequestering of actin monomers (GO:0042989)2.80727202
124carnitine transport (GO:0015879)2.80250997
125amino-acid betaine transport (GO:0015838)2.80250997
126centriole assembly (GO:0098534)2.79080724
127centrosome duplication (GO:0051298)2.78251983
128gene silencing (GO:0016458)2.78241807
129regulation of cilium assembly (GO:1902017)2.77263642
130regulation of acrosome reaction (GO:0060046)2.76398166
131cilium morphogenesis (GO:0060271)2.74585775
132protein complex localization (GO:0031503)2.72155235
133genitalia morphogenesis (GO:0035112)2.72080097
134protein localization to chromosome, centromeric region (GO:0071459)2.70715772
135positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.70603129
136chromatin silencing (GO:0006342)2.67519930
137cellular protein catabolic process (GO:0044257)2.66492060
138carnitine transmembrane transport (GO:1902603)2.61784516
139oocyte maturation (GO:0001556)2.58800193
140mitochondrial fission (GO:0000266)2.57876414
141regulation of histone H3-K27 methylation (GO:0061085)2.56594213
142regulation of meiosis I (GO:0060631)2.52451886
143interferon-gamma secretion (GO:0072643)2.51292701
144protein refolding (GO:0042026)2.49976413
145phosphatidylglycerol biosynthetic process (GO:0006655)2.47640360
146female gonad development (GO:0008585)2.43493118
147protein depolymerization (GO:0051261)2.42765203
148regulation of meiosis (GO:0040020)2.41943147
149protein K11-linked deubiquitination (GO:0035871)2.41556182
150positive regulation of microtubule polymerization (GO:0031116)2.40793165
151amine biosynthetic process (GO:0009309)2.38121338
152sperm motility (GO:0030317)12.2678907
153acrosome reaction (GO:0007340)11.2209529
154cell wall macromolecule catabolic process (GO:0016998)10.7789624
155cell wall macromolecule metabolic process (GO:0044036)10.7789624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.00914723
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.77351397
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.28320987
4EZH2_22144423_ChIP-Seq_EOC_Human4.06641132
5E2F7_22180533_ChIP-Seq_HELA_Human3.84524129
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.62143974
7VDR_22108803_ChIP-Seq_LS180_Human3.36142882
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.33418537
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.99749964
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.88666420
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.86947875
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85532171
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57428106
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52795594
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40795953
16P68_20966046_ChIP-Seq_HELA_Human2.40540499
17CIITA_25753668_ChIP-Seq_RAJI_Human2.25337113
18* PKCTHETA_26484144_Chip-Seq_BREAST_Human2.18780053
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18192621
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.13896727
21MAF_26560356_Chip-Seq_TH2_Human2.09587567
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08978127
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06886480
24XRN2_22483619_ChIP-Seq_HELA_Human2.03988235
25* KDM5A_27292631_Chip-Seq_BREAST_Human1.96144610
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92968408
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87171116
28BCL6_27268052_Chip-Seq_Bcells_Human1.86568479
29BCOR_27268052_Chip-Seq_Bcells_Human1.85376371
30KAP1_22055183_ChIP-Seq_ESCs_Mouse1.84132388
31PHF8_20622854_ChIP-Seq_HELA_Human1.83938949
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83647250
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79796370
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.78170424
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74857550
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.74176253
37E2F1_20622854_ChIP-Seq_HELA_Human1.72482670
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.71707331
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70593170
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69584253
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.67317762
42VDR_21846776_ChIP-Seq_THP-1_Human1.61032652
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.59870624
44REST_21632747_ChIP-Seq_MESCs_Mouse1.58713890
45TAF15_26573619_Chip-Seq_HEK293_Human1.57830559
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56366892
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.55746983
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55473867
49STAT1_17558387_ChIP-Seq_HELA_Human1.55342317
50LXR_22292898_ChIP-Seq_THP-1_Human1.55233733
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54342869
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.53591691
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52801082
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.50617668
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50185896
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50037549
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49949646
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49799577
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48878797
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48801656
61SMC4_20622854_ChIP-Seq_HELA_Human1.48623281
62ZNF274_21170338_ChIP-Seq_K562_Hela1.48343522
63FOXP1_21924763_ChIP-Seq_HESCs_Human1.47251622
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45828789
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44845071
66ERA_21632823_ChIP-Seq_H3396_Human1.44239476
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42938915
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42574622
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42574622
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.41863948
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41381829
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40940644
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.39451781
74FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39395787
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38881174
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38130781
77MYC_22102868_ChIP-Seq_BL_Human1.36540423
78KDM2B_26808549_Chip-Seq_REH_Human1.35829564
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35703127
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34846939
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33115496
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33098660
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33056922
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32250248
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31932030
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.30983239
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.30829029
88ERG_20517297_ChIP-Seq_VCAP_Human1.29329435
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.28751725
90GABP_19822575_ChIP-Seq_HepG2_Human1.28527785
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28256307
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27738664
93P53_21459846_ChIP-Seq_SAOS-2_Human1.27610030
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27489265
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.27052169
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26322664
97CTCF_21964334_Chip-Seq_Bcells_Human1.23640281
98* MAF_26560356_Chip-Seq_TH1_Human1.23569453
99RAC3_21632823_ChIP-Seq_H3396_Human1.23485899
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.23345441
101CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21883506
102JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21676035
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.20939458
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20828643
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20617687
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18405929
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18320028
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18223230
109GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.17815889
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17115689
111GF1_26923725_Chip-Seq_HPCs_Mouse1.16127390
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.16011507
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15826912
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.15746013
115GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14484664
116TBL1_22424771_ChIP-Seq_293T_Human1.14349604
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12624002
118SA1_27219007_Chip-Seq_Bcells_Human1.12507813
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12155682
120ETV1_20927104_ChIP-Seq_GIST48_Human1.12097863
121RNF2_27304074_Chip-Seq_NSC_Mouse1.11883783
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.11502144
123P300_27268052_Chip-Seq_Bcells_Human1.11256113
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10527612
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10056785
126OCT4_20526341_ChIP-Seq_ESCs_Human1.09998160
127SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09517048
128* UTX_26944678_Chip-Seq_JUKART_Human1.09270735
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09130945
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08779254
131TP63_19390658_ChIP-ChIP_HaCaT_Human1.08504138
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08440223
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08440165
134DCP1A_22483619_ChIP-Seq_HELA_Human1.08339460
135PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08196588
136IGF1R_20145208_ChIP-Seq_DFB_Human1.07444753
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07416424
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07244357
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06164172
140CBX2_27304074_Chip-Seq_ESCs_Mouse1.05845583
141SPI1_26923725_Chip-Seq_HPCs_Mouse1.05831272
142NFYB_21822215_ChIP-Seq_K562_Human1.05254247
143MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05051886
144NFYA_21822215_ChIP-Seq_K562_Human1.04945695
145TET1_21451524_ChIP-Seq_MESCs_Mouse1.04936660
146* CTCF_27219007_Chip-Seq_Bcells_Human1.04294213
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.04225884
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04124921
149VDR_23849224_ChIP-Seq_CD4+_Human1.04064887
150RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03923028
151E2F1_21310950_ChIP-Seq_MCF-7_Human1.03650168
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03512177
153RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02907982
154RARB_24833708_ChIP-Seq_LIVER_Mouse1.02893806
155MYC_27129775_Chip-Seq_CORNEA_Mouse1.02709653
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01888126
157CRX_20693478_ChIP-Seq_RETINA_Mouse1.01862517
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01685144
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01385913
160NANOG_20526341_ChIP-Seq_ESCs_Human1.00623676
161ETS1_21867929_ChIP-Seq_TH2_Mouse1.00493901
162TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99931513
163ESET_19884257_ChIP-Seq_ESCs_Mouse0.99796760
164* KDM2B_26808549_Chip-Seq_DND41_Human0.99417461
165EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99306007
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99289275
167OCT1_27270436_Chip-Seq_PROSTATE_Human0.99262945
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98186961
169* CTCF_20526341_ChIP-Seq_ESCs_Human0.97191581
170* CREB1_26743006_Chip-Seq_LNCaP_Human0.97181628
171SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96531633
172CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94995505
173CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93663607
174FUS_26573619_Chip-Seq_HEK293_Human0.93412881
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93298473
176P53_22387025_ChIP-Seq_ESCs_Mouse0.92787963
177CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92549034
178CMYC_18555785_Chip-Seq_ESCs_Mouse0.91904827
179MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91819954
180HNFA_21074721_ChIP-Seq_CACO-2_Human0.91245947
181IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91238569
182CBP_20019798_ChIP-Seq_JUKART_Human0.91238569
183FLI1_21867929_ChIP-Seq_CD8_Mouse0.90690824
184KLF4_18555785_Chip-Seq_ESCs_Mouse0.90506130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.94440862
2MP0001929_abnormal_gametogenesis4.81250057
3MP0005423_abnormal_somatic_nervous4.63366150
4MP0008877_abnormal_DNA_methylation3.69524185
5MP0010094_abnormal_chromosome_stability3.66424905
6MP0005645_abnormal_hypothalamus_physiol3.10824978
7MP0008058_abnormal_DNA_repair3.03582096
8MP0002210_abnormal_sex_determination3.02911164
9MP0002161_abnormal_fertility/fecundity2.95518762
10MP0003646_muscle_fatigue2.87924149
11MP0002653_abnormal_ependyma_morphology2.87240598
12MP0001986_abnormal_taste_sensitivity2.70172051
13MP0002009_preneoplasia2.62635621
14MP0005451_abnormal_body_composition2.49889301
15MP0001145_abnormal_male_reproductive2.47933693
16MP0000653_abnormal_sex_gland2.38650483
17MP0005083_abnormal_biliary_tract2.11220585
18MP0004270_analgesia2.08807360
19MP0005410_abnormal_fertilization13.0735434
20MP0002735_abnormal_chemical_nociception1.98770552
21MP0001348_abnormal_lacrimal_gland1.91849963
22MP0005670_abnormal_white_adipose1.82373949
23MP0002751_abnormal_autonomic_nervous1.80918727
24MP0003880_abnormal_central_pattern1.73818836
25MP0004233_abnormal_muscle_weight1.63860667
26MP0002102_abnormal_ear_morphology1.56810065
27MP0006292_abnormal_olfactory_placode1.51201621
28MP0005253_abnormal_eye_physiology1.44722394
29MP0001765_abnormal_ion_homeostasis1.44208509
30MP0003718_maternal_effect1.43581818
31MP0001968_abnormal_touch/_nociception1.35724714
32MP0009046_muscle_twitch1.33520973
33MP0001984_abnormal_olfaction1.32266324
34MP0003786_premature_aging1.28626461
35MP0004859_abnormal_synaptic_plasticity1.27351104
36MP0003123_paternal_imprinting1.26568707
37MP0002163_abnormal_gland_morphology1.26226904
38MP0004957_abnormal_blastocyst_morpholog1.26195719
39MP0003635_abnormal_synaptic_transmissio1.24527510
40MP0005379_endocrine/exocrine_gland_phen1.20877237
41MP0002837_dystrophic_cardiac_calcinosis1.20248600
42MP0006276_abnormal_autonomic_nervous1.13799389
43MP0002822_catalepsy1.13598583
44MP0008007_abnormal_cellular_replicative1.13265037
45MP0003699_abnormal_female_reproductive1.12644844
46MP0010307_abnormal_tumor_latency1.12076810
47MP0004197_abnormal_fetal_growth/weight/1.08848145
48MP0002572_abnormal_emotion/affect_behav1.08287226
49MP0003221_abnormal_cardiomyocyte_apopto1.07780761
50MP0005394_taste/olfaction_phenotype1.06391426
51MP0005499_abnormal_olfactory_system1.06391426
52MP0008995_early_reproductive_senescence1.04125622
53MP0000313_abnormal_cell_death1.04064536
54MP0006072_abnormal_retinal_apoptosis1.02505954
55MP0002736_abnormal_nociception_after1.01980099
56MP0005171_absent_coat_pigmentation1.01680065
57MP0002234_abnormal_pharynx_morphology1.01113724
58MP0005464_abnormal_platelet_physiology0.97240835
59MP0002272_abnormal_nervous_system0.96239851
60MP0002734_abnormal_mechanical_nocicepti0.95380704
61MP0001502_abnormal_circadian_rhythm0.93267252
62MP0009745_abnormal_behavioral_response0.90452800
63MP0003121_genomic_imprinting0.90006678
64MP0005636_abnormal_mineral_homeostasis0.88392634
65MP0008932_abnormal_embryonic_tissue0.87513881
66MP0002063_abnormal_learning/memory/cond0.87111046
67MP0004133_heterotaxia0.86996837
68MP0005647_abnormal_sex_gland0.86790294
69MP0003879_abnormal_hair_cell0.86551189
70MP0008789_abnormal_olfactory_epithelium0.85891602
71MP0003329_amyloid_beta_deposits0.84614300
72MP0001963_abnormal_hearing_physiology0.83756293
73MP0000358_abnormal_cell_content/0.83108615
74MP0000778_abnormal_nervous_system0.79699238
75MP0002166_altered_tumor_susceptibility0.79399973
76MP0005391_vision/eye_phenotype0.77679454
77MP0003787_abnormal_imprinting0.77678506
78MP0002638_abnormal_pupillary_reflex0.76761997
79MP0002064_seizures0.76433743
80MP0006035_abnormal_mitochondrial_morpho0.76417788
81MP0001485_abnormal_pinna_reflex0.75922481
82MP0000462_abnormal_digestive_system0.75086409
83MP0003938_abnormal_ear_development0.74947576
84MP0008260_abnormal_autophagy0.74753637
85MP0003693_abnormal_embryo_hatching0.72671351
86MP0005408_hypopigmentation0.71626361
87MP0002160_abnormal_reproductive_system0.71472056
88MP0004145_abnormal_muscle_electrophysio0.71430473
89MP0001119_abnormal_female_reproductive0.71320930
90MP0001529_abnormal_vocalization0.71014375
91MP0001764_abnormal_homeostasis0.68798730
92MP0002733_abnormal_thermal_nociception0.67452752
93MP0001486_abnormal_startle_reflex0.66729542
94MP0000026_abnormal_inner_ear0.66556678
95MP0002019_abnormal_tumor_incidence0.66036332
96MP0002080_prenatal_lethality0.65095703
97MP0003111_abnormal_nucleus_morphology0.65078993
98MP0001873_stomach_inflammation0.64230834
99MP0003950_abnormal_plasma_membrane0.63893447
100MP0000639_abnormal_adrenal_gland0.63498171
101MP0002184_abnormal_innervation0.63062732
102MP0008875_abnormal_xenobiotic_pharmacok0.62816214
103MP0004510_myositis0.62704354
104MP0009278_abnormal_bone_marrow0.62693277
105MP0001501_abnormal_sleep_pattern0.62321061
106MP0002882_abnormal_neuron_morphology0.62210101
107MP0000470_abnormal_stomach_morphology0.60947966
108MP0002067_abnormal_sensory_capabilities0.60812991
109MP0000013_abnormal_adipose_tissue0.59882084
110MP0002249_abnormal_larynx_morphology0.59738199
111MP0005220_abnormal_exocrine_pancreas0.59553786
112MP0010386_abnormal_urinary_bladder0.58678705
113MP0000751_myopathy0.58429290
114MP0003878_abnormal_ear_physiology0.58178004
115MP0005377_hearing/vestibular/ear_phenot0.58178004
116MP0002398_abnormal_bone_marrow0.58011661
117MP0002152_abnormal_brain_morphology0.57907271
118MP0001324_abnormal_eye_pigmentation0.57529970
119MP0000631_abnormal_neuroendocrine_gland0.57497264
120MP0002557_abnormal_social/conspecific_i0.56551622
121MP0004808_abnormal_hematopoietic_stem0.56499371
122MP0004742_abnormal_vestibular_system0.56032086
123MP0002277_abnormal_respiratory_mucosa0.56016029
124MP0002006_tumorigenesis0.55522113
125MP0002069_abnormal_eating/drinking_beha0.55482261
126MP0000955_abnormal_spinal_cord0.55133273
127MP0002752_abnormal_somatic_nervous0.54969603
128MP0002693_abnormal_pancreas_physiology0.54728350
129MP0001970_abnormal_pain_threshold0.54707605
130MP0008770_decreased_survivor_rate0.54649509
131MP0002132_abnormal_respiratory_system0.53920480
132MP0003861_abnormal_nervous_system0.53859258
133MP0005551_abnormal_eye_electrophysiolog0.53437565
134MP0002269_muscular_atrophy0.52307331
135MP0001440_abnormal_grooming_behavior0.52048410
136MP0001905_abnormal_dopamine_level0.51985129
137MP0002085_abnormal_embryonic_tissue0.51736528
138MP0000015_abnormal_ear_pigmentation0.51292643
139MP0000427_abnormal_hair_cycle0.51238318
140MP0001270_distended_abdomen0.50830951
141MP0002722_abnormal_immune_system0.50088087
142MP0005310_abnormal_salivary_gland0.49818415
143MP0001881_abnormal_mammary_gland0.48982315
144MP0000534_abnormal_ureter_morphology0.48684461
145MP0002066_abnormal_motor_capabilities/c0.48286763
146MP0002332_abnormal_exercise_endurance0.48231006
147MP0001944_abnormal_pancreas_morphology0.47142852
148MP0003959_abnormal_lean_body0.45145319
149MP0003631_nervous_system_phenotype0.45126131
150MP0002909_abnormal_adrenal_gland0.45050125
151MP0001661_extended_life_span0.43200502
152MP0003077_abnormal_cell_cycle0.42878425
153MP0003633_abnormal_nervous_system0.42777101
154MP0008961_abnormal_basal_metabolism0.42382238
155MP0005395_other_phenotype0.42223828
156MP0005389_reproductive_system_phenotype0.41627136

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.18477503
2Abnormal respiratory epithelium morphology (HP:0012253)7.45131416
3Abnormal respiratory motile cilium morphology (HP:0005938)7.45131416
4Chronic bronchitis (HP:0004469)7.19922875
5Infertility (HP:0000789)6.89841063
6Rhinitis (HP:0012384)6.19088669
7Abnormal ciliary motility (HP:0012262)5.91228986
8Male infertility (HP:0003251)5.62873670
9Chronic hepatic failure (HP:0100626)5.12980311
10Nasal polyposis (HP:0100582)4.20192860
11Bronchiectasis (HP:0002110)3.95344451
12Testicular atrophy (HP:0000029)3.90534327
13Abnormal spermatogenesis (HP:0008669)3.84310003
14Asymmetric septal hypertrophy (HP:0001670)3.64971504
15Nephronophthisis (HP:0000090)3.58803772
16Impulsivity (HP:0100710)3.58157627
17Bronchitis (HP:0012387)3.46022915
18Cone-rod dystrophy (HP:0000548)3.43586670
19Spontaneous abortion (HP:0005268)3.30797923
20Abnormality of the nasal mucosa (HP:0000433)3.22432535
21Cholecystitis (HP:0001082)3.12129153
22Abnormal gallbladder physiology (HP:0012438)3.12129153
23Attenuation of retinal blood vessels (HP:0007843)3.07672680
24Severe visual impairment (HP:0001141)3.07410219
25Recurrent otitis media (HP:0000403)2.92647206
26Bony spicule pigmentary retinopathy (HP:0007737)2.91177347
27Impaired vibration sensation in the lower limbs (HP:0002166)2.86947069
28Azoospermia (HP:0000027)2.85037053
29Rib fusion (HP:0000902)2.82865348
30Myelodysplasia (HP:0002863)2.78935261
31Hand muscle atrophy (HP:0009130)2.77802685
32Hypoplasia of the thymus (HP:0000778)2.77249478
33Upper limb muscle weakness (HP:0003484)2.73973807
34Medial flaring of the eyebrow (HP:0010747)2.73441502
35Type 2 muscle fiber atrophy (HP:0003554)2.69841733
36Abnormality of the renal medulla (HP:0100957)2.68817384
37Long foot (HP:0001833)2.67764272
38Neurofibrillary tangles (HP:0002185)2.61915551
39Poikiloderma (HP:0001029)2.61610336
40Duodenal stenosis (HP:0100867)2.57696614
41Small intestinal stenosis (HP:0012848)2.57696614
42Molar tooth sign on MRI (HP:0002419)2.55741577
43Abnormality of midbrain morphology (HP:0002418)2.55741577
44Agitation (HP:0000713)2.51857424
45Delayed epiphyseal ossification (HP:0002663)2.49314528
46Thrombocytosis (HP:0001894)2.48350045
47Abnormality of the hepatic vasculature (HP:0006707)2.48319815
48Aplasia/Hypoplasia of the lens (HP:0008063)2.47147499
49Pancreatic fibrosis (HP:0100732)2.44839409
50Menstrual irregularities (HP:0000858)2.40569114
51Patellar aplasia (HP:0006443)2.39130158
52Muscle fiber atrophy (HP:0100295)2.36054091
53Abnormality of the neuromuscular junction (HP:0003398)2.29974010
54Fatigable weakness (HP:0003473)2.29974010
55Squamous cell carcinoma (HP:0002860)2.27221162
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27153382
57Sloping forehead (HP:0000340)2.26668922
58Polyphagia (HP:0002591)2.25543363
59Tubulointerstitial nephritis (HP:0001970)2.21520075
60Abnormality of DNA repair (HP:0003254)2.21511004
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21413415
62Decreased muscle mass (HP:0003199)2.20525572
63Metaphyseal cupping (HP:0003021)2.19243475
64Nonprogressive disorder (HP:0003680)2.18818136
65Optic nerve coloboma (HP:0000588)2.16640377
66Congenital malformation of the right heart (HP:0011723)2.16347201
67Double outlet right ventricle (HP:0001719)2.16347201
68Resting tremor (HP:0002322)2.15516500
69Upper limb amyotrophy (HP:0009129)2.14957434
70Distal upper limb amyotrophy (HP:0007149)2.14957434
71Hemiparesis (HP:0001269)2.14722521
72Gait imbalance (HP:0002141)2.13990517
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.13220917
74Aplasia/Hypoplasia of the patella (HP:0006498)2.12401622
75Short nail (HP:0001799)2.10880425
76Recurrent sinusitis (HP:0011108)2.09938658
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06355564
78Congenital primary aphakia (HP:0007707)2.05220848
79Genital tract atresia (HP:0001827)2.02135265
80Retinal dysplasia (HP:0007973)2.01957928
81Hypoparathyroidism (HP:0000829)2.01902454
82Abnormality of the parathyroid morphology (HP:0011766)2.01199493
83Flat occiput (HP:0005469)2.01150132
84Increased intramyocellular lipid droplets (HP:0012240)2.00975108
85Amaurosis fugax (HP:0100576)2.00972537
86Cerebral inclusion bodies (HP:0100314)2.00464567
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.1698792
88Absent/shortened dynein arms (HP:0200106)10.2094463
89Dynein arm defect of respiratory motile cilia (HP:0012255)10.2094463
90Supranuclear gaze palsy (HP:0000605)1.99464527
91Abnormality of the ileum (HP:0001549)1.99279155
92Abnormal biliary tract physiology (HP:0012439)1.98930545
93Bile duct proliferation (HP:0001408)1.98930545
94Meckel diverticulum (HP:0002245)1.97537472
95Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96520362
96Portal hypertension (HP:0001409)1.94838174
97Abnormality of macular pigmentation (HP:0008002)1.93175681
98Vaginal atresia (HP:0000148)1.92722241
99Panhypogammaglobulinemia (HP:0003139)1.91699196
100Vaginal fistula (HP:0004320)1.91604865
101Spastic gait (HP:0002064)1.91362423
102Intestinal fistula (HP:0100819)1.90900398
103Renal dysplasia (HP:0000110)1.89598898
104Tinnitus (HP:0000360)1.88932635
105Abnormality of dental color (HP:0011073)1.88679527
106Enlarged epiphyses (HP:0010580)1.88476597
107Abnormality of lateral ventricle (HP:0030047)1.88310201
108Tubular atrophy (HP:0000092)1.88272473
109Renovascular hypertension (HP:0100817)1.88059379
110Abnormality of the duodenum (HP:0002246)1.85351789
111Progressive sensorineural hearing impairment (HP:0000408)1.84883041
112Potter facies (HP:0002009)1.84071771
113Facial shape deformation (HP:0011334)1.84071771
114Long clavicles (HP:0000890)1.83100756
115Progressive external ophthalmoplegia (HP:0000590)1.81764381
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.81635660
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81635660
118Easy fatigability (HP:0003388)1.81564981
119Neoplasm of the adrenal cortex (HP:0100641)1.80922865
120Tubulointerstitial abnormality (HP:0001969)1.80603701
121Nephrogenic diabetes insipidus (HP:0009806)1.79911030
122Insulin-resistant diabetes mellitus (HP:0000831)1.79707538
123Cystic liver disease (HP:0006706)1.79427081
124Pancreatic cysts (HP:0001737)1.78902294
125Ulnar bowing (HP:0003031)1.77864589
126Poor coordination (HP:0002370)1.77250364
127Failure to thrive in infancy (HP:0001531)1.76697974
128Abnormality of the corticospinal tract (HP:0002492)1.76082304
129Sclerocornea (HP:0000647)1.75312103
130Thin bony cortex (HP:0002753)1.73871859
131Increased muscle lipid content (HP:0009058)1.73137360
132Combined immunodeficiency (HP:0005387)1.73123073
133Embryonal neoplasm (HP:0002898)1.73027613
134EMG: neuropathic changes (HP:0003445)1.72822737
135Decreased central vision (HP:0007663)1.71657451
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71050707
137Spastic tetraparesis (HP:0001285)1.70342268
138Impaired vibratory sensation (HP:0002495)1.68420874
139Dyschromatopsia (HP:0007641)1.65907319
140Thin ribs (HP:0000883)1.65638429
141Hypotelorism (HP:0000601)1.65395644
142Flattened epiphyses (HP:0003071)1.65347616
143Abnormality of the renal cortex (HP:0011035)1.64348483
144Adrenal hypoplasia (HP:0000835)1.64041459
145Abnormal drinking behavior (HP:0030082)1.61852093
146Polydipsia (HP:0001959)1.61852093
147Hyperkalemia (HP:0002153)1.61832922
148Poor suck (HP:0002033)1.61097606
149Abnormality of dentin (HP:0010299)1.60053038
150Lip pit (HP:0100267)1.59375600
151Choroideremia (HP:0001139)1.58528117
152True hermaphroditism (HP:0010459)1.57878826
153Postaxial hand polydactyly (HP:0001162)1.56288857
154Neoplasm of the heart (HP:0100544)1.53748352
155Abnormality of cochlea (HP:0000375)1.51688854
156Postaxial foot polydactyly (HP:0001830)1.50547708
157Congenital hepatic fibrosis (HP:0002612)1.49998275
158Truncus arteriosus (HP:0001660)1.47473266
159Peripheral hypomyelination (HP:0007182)1.43128684
160Abnormality of the dental pulp (HP:0006479)1.42285375
161Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.41847588
162Autoimmune hemolytic anemia (HP:0001890)1.41731199
163Unsteady gait (HP:0002317)1.40583017
164Broad foot (HP:0001769)1.39165815
165Abnormality of permanent molar morphology (HP:0011071)1.38865018
166Abnormality of the dental root (HP:0006486)1.38865018
167Taurodontia (HP:0000679)1.38865018
168Supernumerary spleens (HP:0009799)1.38306372
169Gowers sign (HP:0003391)1.37594473
170Stage 5 chronic kidney disease (HP:0003774)1.36745783
171Anomalous pulmonary venous return (HP:0010772)1.36068673
172Bundle branch block (HP:0011710)1.35679522
173Truncal obesity (HP:0001956)1.34729511
174Weak cry (HP:0001612)1.34617827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.47431353
2PRKD34.80728071
3PDK44.74013343
4PDK34.74013343
5ZAK4.46466113
6BRD44.14870421
7MAPK152.97599183
8ICK2.81661923
9PKN22.73857335
10PDK22.73165348
11SRPK12.61941141
12CDK32.60511362
13LATS22.56180350
14MAP3K132.44121430
15TNK22.38883056
16CAMK1D2.38629195
17CAMK1G2.32754213
18MOS2.17774250
19STK382.08227722
20STK38L1.97003188
21INSRR1.90429266
22DYRK21.87324242
23NEK21.85698706
24PLK21.82724288
25BUB11.78685263
26WNK41.76183123
27KSR21.71047676
28EIF2AK11.64739088
29NEK61.61293358
30ARAF1.59873117
31DYRK31.59034948
32MAP3K91.54100206
33IRAK21.50793737
34CAMKK21.47226001
35DYRK1B1.43719688
36TAOK11.43511175
37ADRBK21.42717098
38PTK2B1.38571643
39MUSK1.34687840
40PRKCG1.34323210
41MAP3K121.25769830
42ERBB41.24018782
43MAP3K61.22857620
44PLK41.22347338
45ATR1.20267130
46FLT31.17296378
47TTK1.15020357
48NTRK31.13279691
49MARK21.08257300
50BMX1.07055916
51PAK61.05993929
52NTRK21.02996259
53EPHA31.00917475
54BMPR21.00836493
55MAP3K100.99143205
56CDK120.97162759
57TYRO30.97025493
58BRAF0.93547554
59PDK10.93387244
60WNK30.93082363
61NTRK10.92611875
62STK390.90192920
63MAP3K40.90126880
64CHEK20.89010494
65PINK10.88648778
66PLK30.87502532
67GRK50.87299823
68BMPR1B0.85797057
69BCKDK0.82237269
70TAOK30.81930300
71BLK0.81692145
72SIK20.76592673
73TNIK0.76387745
74TRIM280.76300065
75LATS10.75457427
76MATK0.75434767
77CDC70.74394791
78HIPK20.74072701
79STK30.73312884
80RPS6KA40.72683740
81CDK20.71882263
82MAP2K70.71182617
83CDK40.69687991
84PRKD20.69096847
85TRIB30.68466015
86SMG10.67973899
87AURKA0.67760646
88CDK10.66777363
89NUAK10.65553224
90PDPK10.62525575
91CDK70.62177480
92ATM0.61896267
93EPHB10.60163303
94RAF10.59775187
95CAMK2A0.58691968
96CAMKK10.58214402
97CCNB10.57732374
98PNCK0.56654249
99VRK10.56112396
100NEK90.54671700
101EPHA40.53902705
102TSSK60.53214441
103STK40.52260345
104PRKCE0.51878406
105BTK0.50782338
106WNK10.49306291
107EEF2K0.49240131
108GSK3B0.43620740
109MAP2K40.43259973
110BRSK10.42951535
111MAPK80.42798150
112PRKCZ0.42389378
113PAK30.41981976
114TESK20.41839849
115STK100.41556293
116MARK10.40017467
117CLK10.39776310
118CDK140.39699265
119MKNK10.39594428
120PKN10.38277924
121PAK10.37771799
122FES0.36999363
123TIE10.36754642
124ACVR1B0.36571181
125PRKAA20.35410668
126RPS6KA50.35329613
127PRKDC0.35264923
128TEC0.33378964
129GRK70.31723161
130PRKAA10.31404212
131CSNK1D0.31374198
132PAK40.30157956
133MINK10.29790980
134EIF2AK30.29442600
135ABL20.28317567
136RIPK40.27841626
137PRKCA0.27152073
138CDK150.26669362
139KSR10.25801741
140CDK11A0.25265500
141PLK10.25073360
142IRAK10.24888091
143DYRK1A0.24283707
144CDK180.24236079
145PASK0.24032977
146TLK10.23375236
147MAPK130.23016259
148ADRBK10.21688964
149IGF1R0.20451535
150BRSK20.19951118
151CHEK10.19074268
152PIK3CG0.18761600
153PHKG10.17583421
154PHKG20.17583421
155AURKB0.17164940
156UHMK10.16593707

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.66458298
2Graft-versus-host disease_Homo sapiens_hsa053324.32417970
3Vitamin B6 metabolism_Homo sapiens_hsa007504.00426494
4Base excision repair_Homo sapiens_hsa034103.77795054
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.67668768
6Linoleic acid metabolism_Homo sapiens_hsa005913.66411320
7Fatty acid biosynthesis_Homo sapiens_hsa000613.63720073
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.54240348
9RNA transport_Homo sapiens_hsa030132.88498020
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.61892381
11Antigen processing and presentation_Homo sapiens_hsa046122.59679715
12Ether lipid metabolism_Homo sapiens_hsa005652.43152884
13Homologous recombination_Homo sapiens_hsa034402.30922355
14Amphetamine addiction_Homo sapiens_hsa050312.29496334
15Basal transcription factors_Homo sapiens_hsa030222.28249264
16Glucagon signaling pathway_Homo sapiens_hsa049222.25735484
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22900945
18Glycerophospholipid metabolism_Homo sapiens_hsa005642.02943623
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98581368
20Oocyte meiosis_Homo sapiens_hsa041141.96141326
21Olfactory transduction_Homo sapiens_hsa047401.95167879
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93041232
23Sulfur relay system_Homo sapiens_hsa041221.88273386
24DNA replication_Homo sapiens_hsa030301.85244604
25Mismatch repair_Homo sapiens_hsa034301.84782349
26Regulation of autophagy_Homo sapiens_hsa041401.82153916
27Nicotine addiction_Homo sapiens_hsa050331.79195290
28Pyruvate metabolism_Homo sapiens_hsa006201.74669272
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69494142
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58494895
31mRNA surveillance pathway_Homo sapiens_hsa030151.52113120
32Insulin secretion_Homo sapiens_hsa049111.51000315
33Collecting duct acid secretion_Homo sapiens_hsa049661.50186436
34Cocaine addiction_Homo sapiens_hsa050301.40554793
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39295776
36mTOR signaling pathway_Homo sapiens_hsa041501.38947284
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37911293
38Renin secretion_Homo sapiens_hsa049241.32721897
39Circadian rhythm_Homo sapiens_hsa047101.31313062
40Steroid biosynthesis_Homo sapiens_hsa001001.31123732
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.25692883
42Cell cycle_Homo sapiens_hsa041101.24529486
43Mineral absorption_Homo sapiens_hsa049781.24236694
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22828886
45Salivary secretion_Homo sapiens_hsa049701.22568413
46Long-term potentiation_Homo sapiens_hsa047201.20994154
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20976058
48Synaptic vesicle cycle_Homo sapiens_hsa047211.19001914
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18776894
50Systemic lupus erythematosus_Homo sapiens_hsa053221.17735327
51One carbon pool by folate_Homo sapiens_hsa006701.16548304
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13129281
53Purine metabolism_Homo sapiens_hsa002301.13053879
54Notch signaling pathway_Homo sapiens_hsa043301.12737696
55Arachidonic acid metabolism_Homo sapiens_hsa005901.12384067
56Glutamatergic synapse_Homo sapiens_hsa047241.11993543
57Ovarian steroidogenesis_Homo sapiens_hsa049131.10165654
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09827371
59Nucleotide excision repair_Homo sapiens_hsa034201.09604298
60Estrogen signaling pathway_Homo sapiens_hsa049151.07963218
61RNA polymerase_Homo sapiens_hsa030201.07246525
62Cardiac muscle contraction_Homo sapiens_hsa042601.02177193
63Fat digestion and absorption_Homo sapiens_hsa049751.00902352
64Spliceosome_Homo sapiens_hsa030401.00057665
65Lysine degradation_Homo sapiens_hsa003100.99548510
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99211438
67Primary immunodeficiency_Homo sapiens_hsa053400.98316648
68Viral carcinogenesis_Homo sapiens_hsa052030.96403771
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.92109244
70Hedgehog signaling pathway_Homo sapiens_hsa043400.91326597
71Butanoate metabolism_Homo sapiens_hsa006500.90690997
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.88628952
73Inositol phosphate metabolism_Homo sapiens_hsa005620.88609852
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87854592
75Glycerolipid metabolism_Homo sapiens_hsa005610.87191554
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87008449
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86555402
78Circadian entrainment_Homo sapiens_hsa047130.85228519
79RNA degradation_Homo sapiens_hsa030180.83563224
80Huntingtons disease_Homo sapiens_hsa050160.81749022
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79809143
82Pyrimidine metabolism_Homo sapiens_hsa002400.79427074
83Pentose phosphate pathway_Homo sapiens_hsa000300.78936856
84Gastric acid secretion_Homo sapiens_hsa049710.78825670
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77515311
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77242181
87p53 signaling pathway_Homo sapiens_hsa041150.76954650
88PPAR signaling pathway_Homo sapiens_hsa033200.75211364
89Taste transduction_Homo sapiens_hsa047420.74900111
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74648699
91Fructose and mannose metabolism_Homo sapiens_hsa000510.74074794
92Thyroid hormone synthesis_Homo sapiens_hsa049180.73775116
93Dorso-ventral axis formation_Homo sapiens_hsa043200.73503932
94GABAergic synapse_Homo sapiens_hsa047270.72940554
95Dopaminergic synapse_Homo sapiens_hsa047280.72052137
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71108611
97Fatty acid metabolism_Homo sapiens_hsa012120.69833075
98Morphine addiction_Homo sapiens_hsa050320.68262002
99cAMP signaling pathway_Homo sapiens_hsa040240.67397606
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66724665
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64932264
102Renin-angiotensin system_Homo sapiens_hsa046140.61628093
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61464966
104Propanoate metabolism_Homo sapiens_hsa006400.61385161
105Fatty acid degradation_Homo sapiens_hsa000710.60456820
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59552206
107Calcium signaling pathway_Homo sapiens_hsa040200.58890387
108Pancreatic secretion_Homo sapiens_hsa049720.58620103
109Legionellosis_Homo sapiens_hsa051340.57862496
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57758002
111Other glycan degradation_Homo sapiens_hsa005110.57453337
112Alcoholism_Homo sapiens_hsa050340.55867529
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53849710
114Oxytocin signaling pathway_Homo sapiens_hsa049210.53354436
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.52145766
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51335274
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.50031425
118Bile secretion_Homo sapiens_hsa049760.49990772
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46887780
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46844201
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46309372
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45689898
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44455084
124Apoptosis_Homo sapiens_hsa042100.43520710
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43252100
126Wnt signaling pathway_Homo sapiens_hsa043100.42485865
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42002278
128Serotonergic synapse_Homo sapiens_hsa047260.41126586
129Vibrio cholerae infection_Homo sapiens_hsa051100.40004106
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39795431
131Selenocompound metabolism_Homo sapiens_hsa004500.39773783
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.39445853
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39091279
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38547875
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36884150
136Phenylalanine metabolism_Homo sapiens_hsa003600.36792264
137Axon guidance_Homo sapiens_hsa043600.36115207
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.35781731
139ABC transporters_Homo sapiens_hsa020100.35154016
140Oxidative phosphorylation_Homo sapiens_hsa001900.34873382
141Cholinergic synapse_Homo sapiens_hsa047250.34059054
142Peroxisome_Homo sapiens_hsa041460.32296753
143Glutathione metabolism_Homo sapiens_hsa004800.32099468
144Endocytosis_Homo sapiens_hsa041440.30526529
145Choline metabolism in cancer_Homo sapiens_hsa052310.29392668
146Carbon metabolism_Homo sapiens_hsa012000.28484828
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28054876
148Biosynthesis of amino acids_Homo sapiens_hsa012300.27859226
149Sphingolipid metabolism_Homo sapiens_hsa006000.27615495
150Fanconi anemia pathway_Homo sapiens_hsa034600.27142853
151Metabolic pathways_Homo sapiens_hsa011000.27066326
152Vitamin digestion and absorption_Homo sapiens_hsa049770.26182925
153GnRH signaling pathway_Homo sapiens_hsa049120.25649147
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25006193
155Phototransduction_Homo sapiens_hsa047440.24720892
156Viral myocarditis_Homo sapiens_hsa054160.24654176
157VEGF signaling pathway_Homo sapiens_hsa043700.24332680
158Sulfur metabolism_Homo sapiens_hsa009200.23448161
159Herpes simplex infection_Homo sapiens_hsa051680.23023401
160Ras signaling pathway_Homo sapiens_hsa040140.22719143

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »