CC2D2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.93480688
2axonemal dynein complex assembly (GO:0070286)9.57772127
3male meiosis (GO:0007140)9.39470551
4cell wall macromolecule metabolic process (GO:0044036)9.31900446
5cell wall macromolecule catabolic process (GO:0016998)9.31900446
6cell-cell recognition (GO:0009988)9.03911001
7reproduction (GO:0000003)8.82367175
8plasma membrane fusion (GO:0045026)8.80545041
9binding of sperm to zona pellucida (GO:0007339)8.74192239
10epithelial cilium movement (GO:0003351)8.45373812
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.09605729
12synaptonemal complex organization (GO:0070193)7.94221405
13acrosome reaction (GO:0007340)7.88098524
14synaptonemal complex assembly (GO:0007130)7.86194383
15cilium movement (GO:0003341)7.85064932
16spermatid development (GO:0007286)7.75770897
17motile cilium assembly (GO:0044458)7.31373549
18regulation of cilium movement (GO:0003352)6.71488452
19single fertilization (GO:0007338)6.70340972
20DNA methylation involved in gamete generation (GO:0043046)6.43346275
21sperm capacitation (GO:0048240)6.42856133
22male meiosis I (GO:0007141)5.78466818
23fertilization (GO:0009566)5.73668069
24indole-containing compound catabolic process (GO:0042436)5.64047640
25indolalkylamine catabolic process (GO:0046218)5.64047640
26tryptophan catabolic process (GO:0006569)5.64047640
27monoubiquitinated protein deubiquitination (GO:0035520)5.58621103
28chromosome organization involved in meiosis (GO:0070192)5.54300801
29meiotic nuclear division (GO:0007126)5.44352864
30DNA double-strand break processing (GO:0000729)5.43443818
31spermatogenesis (GO:0007283)4.97100987
32male gamete generation (GO:0048232)4.95520473
33indolalkylamine metabolic process (GO:0006586)4.94906444
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.74209254
35negative regulation of inclusion body assembly (GO:0090084)4.72491892
36meiosis I (GO:0007127)4.69691356
37meiotic cell cycle (GO:0051321)4.69185781
38gamete generation (GO:0007276)4.63994712
39seminiferous tubule development (GO:0072520)4.63720425
40tryptophan metabolic process (GO:0006568)4.61151164
41germ cell development (GO:0007281)4.60984590
42ventricular system development (GO:0021591)4.52741670
43neural tube formation (GO:0001841)4.39187521
44intraciliary transport (GO:0042073)4.37529649
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.21805555
46microtubule severing (GO:0051013)4.20121724
47gene silencing by RNA (GO:0031047)4.09990149
48regulation of microtubule-based movement (GO:0060632)4.07884183
49kynurenine metabolic process (GO:0070189)4.06991392
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.05658821
51organic cation transport (GO:0015695)3.95961566
52left/right pattern formation (GO:0060972)3.90847822
53cell recognition (GO:0008037)3.87983469
54calcium ion-dependent exocytosis (GO:0017156)3.87893112
55protein polyglutamylation (GO:0018095)3.82655452
56amine catabolic process (GO:0009310)3.74442805
57cellular biogenic amine catabolic process (GO:0042402)3.74442805
58regulation of meiosis I (GO:0060631)3.73519463
59microtubule depolymerization (GO:0007019)3.70832224
60protein localization to cilium (GO:0061512)3.68444390
61spermatid nucleus differentiation (GO:0007289)3.65627437
62multicellular organismal reproductive process (GO:0048609)3.65088041
63aromatic amino acid family catabolic process (GO:0009074)3.60537202
64genitalia morphogenesis (GO:0035112)3.55831048
65L-fucose catabolic process (GO:0042355)3.52936651
66fucose catabolic process (GO:0019317)3.52936651
67L-fucose metabolic process (GO:0042354)3.52936651
68centriole replication (GO:0007099)3.52455823
69amino acid salvage (GO:0043102)3.51245280
70L-methionine salvage (GO:0071267)3.51245280
71L-methionine biosynthetic process (GO:0071265)3.51245280
72regulation of inclusion body assembly (GO:0090083)3.46739350
73preassembly of GPI anchor in ER membrane (GO:0016254)3.46015752
74meiotic cell cycle process (GO:1903046)3.44942451
75retinal cone cell development (GO:0046549)3.39842802
76photoreceptor cell maintenance (GO:0045494)3.38119456
77indole-containing compound metabolic process (GO:0042430)3.35825849
78mitochondrial DNA replication (GO:0006264)3.35474121
79positive regulation of developmental pigmentation (GO:0048087)3.30592574
80centriole assembly (GO:0098534)3.29034516
81lactate metabolic process (GO:0006089)3.27759204
82detection of light stimulus involved in sensory perception (GO:0050962)3.26177110
83detection of light stimulus involved in visual perception (GO:0050908)3.26177110
84synapsis (GO:0007129)3.22037745
85axoneme assembly (GO:0035082)3.21462384
86cilium organization (GO:0044782)3.21365643
87xenobiotic catabolic process (GO:0042178)3.21137803
88benzene-containing compound metabolic process (GO:0042537)3.18333652
89regulation of centriole replication (GO:0046599)3.15053644
90regulation of hippo signaling (GO:0035330)3.13388887
91cornea development in camera-type eye (GO:0061303)3.10491514
92methionine biosynthetic process (GO:0009086)3.09573359
93Golgi transport vesicle coating (GO:0048200)3.08084931
94COPI coating of Golgi vesicle (GO:0048205)3.08084931
95cilium assembly (GO:0042384)3.07157816
96microtubule-based movement (GO:0007018)3.05535487
97signal peptide processing (GO:0006465)2.98417971
98glycerol ether metabolic process (GO:0006662)2.97930051
99NAD biosynthetic process (GO:0009435)2.95397936
100sulfation (GO:0051923)2.93061529
101aromatic amino acid family metabolic process (GO:0009072)2.91563940
102establishment of protein localization to Golgi (GO:0072600)2.91206532
103adenosine metabolic process (GO:0046085)2.90952788
104negative regulation of organelle assembly (GO:1902116)2.90891218
105negative regulation of cAMP-mediated signaling (GO:0043951)2.89655792
106detection of mechanical stimulus involved in sensory perception (GO:0050974)2.87438070
107protein K11-linked deubiquitination (GO:0035871)2.87115730
108cellular component assembly involved in morphogenesis (GO:0010927)2.83471149
109multicellular organismal development (GO:0007275)2.83367692
110mannosylation (GO:0097502)2.80593632
111cellular ketone body metabolic process (GO:0046950)2.77225933
112interkinetic nuclear migration (GO:0022027)2.76559700
113regulation of pigment cell differentiation (GO:0050932)2.76066860
114double-strand break repair via homologous recombination (GO:0000724)2.75381949
115histone H3-K9 methylation (GO:0051567)2.74649856
116recombinational repair (GO:0000725)2.74317774
117reflex (GO:0060004)2.73048908
118nuclear pore complex assembly (GO:0051292)2.72981159
119tachykinin receptor signaling pathway (GO:0007217)2.72423443
120sister chromatid cohesion (GO:0007062)2.71665013
121ether metabolic process (GO:0018904)2.71180515
122cellular response to sterol (GO:0036315)2.69166004
123cilium morphogenesis (GO:0060271)2.68989928
124behavioral response to ethanol (GO:0048149)2.68266574
125cellular response to gamma radiation (GO:0071480)2.68017286
126auditory receptor cell stereocilium organization (GO:0060088)2.67431096
127prenylation (GO:0097354)2.67191774
128protein prenylation (GO:0018342)2.67191774
129DNA methylation (GO:0006306)2.66834184
130DNA alkylation (GO:0006305)2.66834184
131polyol catabolic process (GO:0046174)2.62814365
132gene silencing (GO:0016458)2.62077164
133transepithelial transport (GO:0070633)2.59450383
134embryonic epithelial tube formation (GO:0001838)2.57651733
135response to pheromone (GO:0019236)2.57252681
136GPI anchor metabolic process (GO:0006505)2.57111883
137histone H3-K9 modification (GO:0061647)2.56796047
138phosphatidylethanolamine biosynthetic process (GO:0006646)2.55656639
139peptidyl-glutamic acid modification (GO:0018200)2.55629396
140protein refolding (GO:0042026)2.55162017
141positive regulation of vasculogenesis (GO:2001214)2.50985819
142photoreceptor cell development (GO:0042461)2.50368793
143ketone body metabolic process (GO:1902224)2.49569294
144phosphatidylethanolamine metabolic process (GO:0046337)2.49144495
145protein K6-linked ubiquitination (GO:0085020)2.48949870
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48948941
147coenzyme catabolic process (GO:0009109)2.48238490
148purinergic nucleotide receptor signaling pathway (GO:0035590)2.48115479
149methionine metabolic process (GO:0006555)2.47613290
150regulation of spindle checkpoint (GO:0090231)2.47272185
151dopamine transport (GO:0015872)2.45413742
152peptidyl-lysine dimethylation (GO:0018027)2.43461459
153carnitine transmembrane transport (GO:1902603)2.41974448
154carnitine transport (GO:0015879)2.37732507
155amino-acid betaine transport (GO:0015838)2.37732507
156COPII vesicle coating (GO:0048208)2.37555141
157DNA integration (GO:0015074)2.37128392
158nucleus organization (GO:0006997)2.36966530
159detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.36473298
160inner ear receptor stereocilium organization (GO:0060122)2.35243450
161atrial cardiac muscle cell action potential (GO:0086014)2.34952518
162regulation of establishment of cell polarity (GO:2000114)2.34450117
163negative regulation of meiosis (GO:0045835)2.34004520
164regulation of cilium assembly (GO:1902017)2.33362130
165epithelial tube formation (GO:0072175)2.32898238
166histone exchange (GO:0043486)2.32891625
167sphingoid metabolic process (GO:0046519)2.32342567
168RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.32248140
169pyrimidine-containing compound transmembrane transport (GO:0072531)2.32140092
170thyroid hormone metabolic process (GO:0042403)2.31617446
171cell redox homeostasis (GO:0045454)2.29404180
172C-terminal protein amino acid modification (GO:0018410)2.29257377
173cilium or flagellum-dependent cell motility (GO:0001539)14.2460981
174fusion of sperm to egg plasma membrane (GO:0007342)11.6657179
175acrosome assembly (GO:0001675)11.0428948
176multicellular organism reproduction (GO:0032504)10.8679392
177piRNA metabolic process (GO:0034587)10.2127516
178sperm-egg recognition (GO:0035036)10.1081250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.47516110
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.66835354
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.74663055
4GBX2_23144817_ChIP-Seq_PC3_Human3.70630156
5IGF1R_20145208_ChIP-Seq_DFB_Human2.94597623
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.74159693
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.73254794
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65184974
9TAF15_26573619_Chip-Seq_HEK293_Human2.63571033
10EZH2_22144423_ChIP-Seq_EOC_Human2.63073362
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41450256
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37763278
13P300_19829295_ChIP-Seq_ESCs_Human2.33684801
14FUS_26573619_Chip-Seq_HEK293_Human2.18158000
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16169526
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.09172599
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08398557
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07268426
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00799836
20EWS_26573619_Chip-Seq_HEK293_Human2.00463929
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.99887008
22ER_23166858_ChIP-Seq_MCF-7_Human1.98662987
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96600204
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95373770
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94587955
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91473267
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.84626714
28ZNF274_21170338_ChIP-Seq_K562_Hela1.73235430
29SMAD4_21799915_ChIP-Seq_A2780_Human1.72811938
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71501792
31STAT3_23295773_ChIP-Seq_U87_Human1.67346483
32BCAT_22108803_ChIP-Seq_LS180_Human1.67102656
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66981128
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.65241258
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64406754
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.63215370
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.62132201
38AR_25329375_ChIP-Seq_VCAP_Human1.62109841
39STAT1_17558387_ChIP-Seq_HELA_Human1.60135299
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59479541
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.58500535
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57642427
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.57629972
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54317523
45OCT4_18555785_Chip-Seq_ESCs_Mouse1.53045787
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50480680
47ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49677853
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49346842
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49282446
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48265584
51KDM2B_26808549_Chip-Seq_REH_Human1.47793165
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47588325
53P53_22387025_ChIP-Seq_ESCs_Mouse1.47058289
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.46899534
55KLF4_18555785_Chip-Seq_ESCs_Mouse1.46708728
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46276870
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.46200845
58VDR_22108803_ChIP-Seq_LS180_Human1.44358806
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.43875999
60NANOG_19829295_ChIP-Seq_ESCs_Human1.43485200
61SOX2_19829295_ChIP-Seq_ESCs_Human1.43485200
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.43101853
63RUNX2_22187159_ChIP-Seq_PCA_Human1.42913510
64TCF4_22108803_ChIP-Seq_LS180_Human1.42251887
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41508877
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40458648
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.39485417
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39311690
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.39152442
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38859330
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38545414
72P300_18555785_Chip-Seq_ESCs_Mouse1.38164492
73ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38162369
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37508921
75CBP_20019798_ChIP-Seq_JUKART_Human1.37508921
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.37064936
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35669682
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.35552741
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.35186172
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.34209536
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33699653
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33455770
83RUNX1_26923725_Chip-Seq_HPCs_Mouse1.32485786
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.32252829
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31761622
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31590164
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.31194470
88TP53_22573176_ChIP-Seq_HFKS_Human1.30728940
89SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28593224
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.27905917
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.27375971
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.26665235
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26192072
94GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.25578232
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25434108
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.25035931
97GATA3_21867929_ChIP-Seq_CD8_Mouse1.24062389
98RNF2_27304074_Chip-Seq_NSC_Mouse1.21326789
99ERG_20517297_ChIP-Seq_VCAP_Human1.18763001
100PU1_27457419_Chip-Seq_LIVER_Mouse1.18657086
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.18244371
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.17238878
103FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16837626
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16421675
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15804824
106WDR5_24793694_ChIP-Seq_LNCAP_Human1.15565059
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13833412
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13112210
109AR_20517297_ChIP-Seq_VCAP_Human1.12117169
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12019444
111GATA3_21867929_ChIP-Seq_TH1_Mouse1.11596066
112AR_21572438_ChIP-Seq_LNCaP_Human1.11500509
113GF1_26923725_Chip-Seq_HPCs_Mouse1.11392248
114AHR_22903824_ChIP-Seq_MCF-7_Human1.10132707
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09237680
116IRF1_19129219_ChIP-ChIP_H3396_Human1.07032473
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05535252
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04230291
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04045744
120TBL1_22424771_ChIP-Seq_293T_Human1.03496998
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.02890843
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02505596
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01993287
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00966458
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00899916
126GATA3_21878914_ChIP-Seq_MCF-7_Human1.00603638
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99713481
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99640641
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98790107
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98703852
131GF1B_26923725_Chip-Seq_HPCs_Mouse0.98512378
132TCF4_23295773_ChIP-Seq_U87_Human0.98398267
133SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97819026
134NFYB_21822215_ChIP-Seq_K562_Human0.97395371
135ETV1_20927104_ChIP-Seq_GIST48_Human0.97394115
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.96978704
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96652162
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.96652162
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96403252
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96157173
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94690106
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94019550
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93028705
144CDX2_22108803_ChIP-Seq_LS180_Human0.92911662
145GATA3_26560356_Chip-Seq_TH1_Human0.92249297
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91200981
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90972235
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90898851
149SCL_19346495_ChIP-Seq_HPC-7_Human0.90574916
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.89892585
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89816523
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89058909
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88517790
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88517790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.54133832
2MP0001929_abnormal_gametogenesis4.89863508
3MP0003698_abnormal_male_reproductive4.88487042
4MP0002210_abnormal_sex_determination3.54758251
5MP0002653_abnormal_ependyma_morphology3.44705761
6MP0001145_abnormal_male_reproductive2.95391959
7MP0000653_abnormal_sex_gland2.72635964
8MP0002161_abnormal_fertility/fecundity2.69573684
9MP0003806_abnormal_nucleotide_metabolis2.65356960
10MP0005551_abnormal_eye_electrophysiolog2.60499145
11MP0002877_abnormal_melanocyte_morpholog2.59030130
12MP0008057_abnormal_DNA_replication2.53057028
13MP0000372_irregular_coat_pigmentation2.49971394
14MP0005360_urolithiasis2.36474444
15MP0008058_abnormal_DNA_repair2.26751151
16MP0003136_yellow_coat_color2.22430571
17MP0000465_gastrointestinal_hemorrhage2.22255131
18MP0010386_abnormal_urinary_bladder2.19143935
19MP0003183_abnormal_peptide_metabolism2.14868497
20MP0006054_spinal_hemorrhage2.14754243
21MP0005410_abnormal_fertilization11.4757269
22MP0001501_abnormal_sleep_pattern1.98346894
23MP0001986_abnormal_taste_sensitivity1.93278030
24MP0002693_abnormal_pancreas_physiology1.87118360
25MP0004043_abnormal_pH_regulation1.84014131
26MP0002102_abnormal_ear_morphology1.82457957
27MP0002138_abnormal_hepatobiliary_system1.79785426
28MP0005379_endocrine/exocrine_gland_phen1.76919065
29MP0001984_abnormal_olfaction1.69361991
30MP0005075_abnormal_melanosome_morpholog1.68593154
31MP0005623_abnormal_meninges_morphology1.68352621
32MP0005167_abnormal_blood-brain_barrier1.66678131
33MP0001486_abnormal_startle_reflex1.66366621
34MP0001968_abnormal_touch/_nociception1.65628153
35MP0004147_increased_porphyrin_level1.55206357
36MP0000383_abnormal_hair_follicle1.53684699
37MP0002736_abnormal_nociception_after1.53007451
38MP0010094_abnormal_chromosome_stability1.51562488
39MP0005310_abnormal_salivary_gland1.48533383
40MP0004215_abnormal_myocardial_fiber1.42655486
41MP0001944_abnormal_pancreas_morphology1.42444181
42MP0002837_dystrophic_cardiac_calcinosis1.41174600
43MP0003724_increased_susceptibility_to1.41095252
44MP0003718_maternal_effect1.40902448
45MP0002160_abnormal_reproductive_system1.40887798
46MP0005248_abnormal_Harderian_gland1.38366133
47MP0001765_abnormal_ion_homeostasis1.36348142
48MP0008872_abnormal_physiological_respon1.36303463
49MP0005670_abnormal_white_adipose1.34504570
50MP0006292_abnormal_olfactory_placode1.34464685
51MP0002928_abnormal_bile_duct1.33269146
52MP0002909_abnormal_adrenal_gland1.32943900
53MP0005084_abnormal_gallbladder_morpholo1.32361079
54MP0005085_abnormal_gallbladder_physiolo1.30569723
55MP0003646_muscle_fatigue1.29905147
56MP0005646_abnormal_pituitary_gland1.29487095
57MP0002938_white_spotting1.29207535
58MP0005389_reproductive_system_phenotype1.27100122
59MP0008004_abnormal_stomach_pH1.25622814
60MP0006035_abnormal_mitochondrial_morpho1.25275407
61MP0004808_abnormal_hematopoietic_stem1.24993777
62MP0000678_abnormal_parathyroid_gland1.24554164
63MP0004084_abnormal_cardiac_muscle1.22420305
64MP0005647_abnormal_sex_gland1.21086174
65MP0004484_altered_response_of1.19056753
66MP0008007_abnormal_cellular_replicative1.17579725
67MP0006276_abnormal_autonomic_nervous1.13788553
68MP0001485_abnormal_pinna_reflex1.11965089
69MP0003880_abnormal_central_pattern1.11074179
70MP0006036_abnormal_mitochondrial_physio1.09615988
71MP0001756_abnormal_urination1.08245237
72MP0004264_abnormal_extraembryonic_tissu1.08018538
73MP0003693_abnormal_embryo_hatching1.07361406
74MP0000230_abnormal_systemic_arterial1.06561607
75MP0003950_abnormal_plasma_membrane1.04549543
76MP0003045_fibrosis1.02757814
77MP0000013_abnormal_adipose_tissue1.01736124
78MP0002876_abnormal_thyroid_physiology1.01583188
79MP0002095_abnormal_skin_pigmentation0.99661632
80MP0009745_abnormal_behavioral_response0.99306595
81MP0005220_abnormal_exocrine_pancreas0.97561186
82MP0001119_abnormal_female_reproductive0.97536381
83MP0002272_abnormal_nervous_system0.96868594
84MP0002090_abnormal_vision0.95063768
85MP0010678_abnormal_skin_adnexa0.91629001
86MP0003699_abnormal_female_reproductive0.89468592
87MP0001661_extended_life_span0.89163926
88MP0003283_abnormal_digestive_organ0.89097293
89MP0006072_abnormal_retinal_apoptosis0.88184909
90MP0004085_abnormal_heartbeat0.87018995
91MP0000538_abnormal_urinary_bladder0.86012433
92MP0001664_abnormal_digestion0.86008778
93MP0003633_abnormal_nervous_system0.85427912
94MP0004381_abnormal_hair_follicle0.85058134
95MP0005377_hearing/vestibular/ear_phenot0.84987234
96MP0003878_abnormal_ear_physiology0.84987234
97MP0009697_abnormal_copulation0.84493700
98MP0005395_other_phenotype0.84440407
99MP0005636_abnormal_mineral_homeostasis0.84175300
100MP0002229_neurodegeneration0.82094991
101MP0009780_abnormal_chondrocyte_physiolo0.81980723
102MP0001970_abnormal_pain_threshold0.81926514
103MP0003195_calcinosis0.81641712
104MP0010307_abnormal_tumor_latency0.81463105
105MP0003787_abnormal_imprinting0.81236361
106MP0005365_abnormal_bile_salt0.80057604
107MP0000569_abnormal_digit_pigmentation0.79959514
108MP0005171_absent_coat_pigmentation0.79181860
109MP0003137_abnormal_impulse_conducting0.79177509
110MP0005397_hematopoietic_system_phenotyp0.78694910
111MP0001545_abnormal_hematopoietic_system0.78694910
112MP0001919_abnormal_reproductive_system0.78598931
113MP0000516_abnormal_urinary_system0.78259973
114MP0005367_renal/urinary_system_phenotyp0.78259973
115MP0003111_abnormal_nucleus_morphology0.77738633
116MP0008995_early_reproductive_senescence0.77496410
117MP0008775_abnormal_heart_ventricle0.76535009
118MP0005266_abnormal_metabolism0.75952533
119MP0009764_decreased_sensitivity_to0.75746525
120MP0002078_abnormal_glucose_homeostasis0.74962027
121MP0003868_abnormal_feces_composition0.74785825
122MP0003252_abnormal_bile_duct0.74689074
123MP0000647_abnormal_sebaceous_gland0.74595955
124MP0002735_abnormal_chemical_nociception0.73735580
125MP0003763_abnormal_thymus_physiology0.72289265
126MP0003943_abnormal_hepatobiliary_system0.71511134
127MP0005464_abnormal_platelet_physiology0.68095276
128MP0008961_abnormal_basal_metabolism0.67074402
129MP0002234_abnormal_pharynx_morphology0.66622478
130MP0002163_abnormal_gland_morphology0.66260769
131MP0001835_abnormal_antigen_presentation0.65100730
132MP0003786_premature_aging0.59673370
133MP0005174_abnormal_tail_pigmentation0.59488584
134MP0005257_abnormal_intraocular_pressure0.59196104
135MP0003077_abnormal_cell_cycle0.57506780
136MP0000313_abnormal_cell_death0.57111251
137MP0000462_abnormal_digestive_system0.56989859
138MP0000427_abnormal_hair_cycle0.55419553
139MP0000631_abnormal_neuroendocrine_gland0.55269374
140MP0005387_immune_system_phenotype0.54172685
141MP0001790_abnormal_immune_system0.54172685
142MP0001764_abnormal_homeostasis0.54164694
143MP0002405_respiratory_system_inflammati0.53265232
144MP0002282_abnormal_trachea_morphology0.51791132
145MP0002638_abnormal_pupillary_reflex0.50859142
146MP0005671_abnormal_response_to0.50246744
147MP0003953_abnormal_hormone_level0.49646644
148MP0003866_abnormal_defecation0.48978085
149MP0004782_abnormal_surfactant_physiolog0.48292861
150MP0005253_abnormal_eye_physiology0.48233124
151MP0002723_abnormal_immune_serum0.47985765
152MP0005451_abnormal_body_composition0.46864000
153MP0002398_abnormal_bone_marrow0.45562132
154MP0000358_abnormal_cell_content/0.45541003
155MP0003172_abnormal_lysosome_physiology0.44908276
156MP0000613_abnormal_salivary_gland0.44497825
157MP0002139_abnormal_hepatobiliary_system0.42791781
158MP0001324_abnormal_eye_pigmentation0.42582923
159MP0009046_muscle_twitch0.41314030
160MP0009643_abnormal_urine_homeostasis0.40669891
161MP0001845_abnormal_inflammatory_respons0.40083920
162MP0000639_abnormal_adrenal_gland0.39766085
163MP0005000_abnormal_immune_tolerance0.36189646
164MP0000015_abnormal_ear_pigmentation0.35989926
165MP0002009_preneoplasia0.35430977
166MP0003656_abnormal_erythrocyte_physiolo0.35356277

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.70855726
2Absent/shortened dynein arms (HP:0200106)9.70855726
3Abnormal respiratory motile cilium physiology (HP:0012261)8.51346959
4Rhinitis (HP:0012384)7.38311152
5Chronic bronchitis (HP:0004469)7.29552204
6Abnormal respiratory epithelium morphology (HP:0012253)7.21604696
7Abnormal respiratory motile cilium morphology (HP:0005938)7.21604696
8Abnormal ciliary motility (HP:0012262)7.14235389
9Nasal polyposis (HP:0100582)5.77632247
10Infertility (HP:0000789)5.56327735
11Bronchitis (HP:0012387)4.92431128
12Abnormality of the nasal mucosa (HP:0000433)4.81232462
13Bronchiectasis (HP:0002110)4.79051847
14Nephronophthisis (HP:0000090)4.26401962
15Male infertility (HP:0003251)3.75209045
16Recurrent sinusitis (HP:0011108)3.67000190
17Renal cortical cysts (HP:0000803)3.56742009
18Molar tooth sign on MRI (HP:0002419)3.44260037
19Abnormality of midbrain morphology (HP:0002418)3.44260037
20Abnormality of the renal medulla (HP:0100957)3.40455644
21Recurrent bronchitis (HP:0002837)3.34350411
22Progressive inability to walk (HP:0002505)3.27288489
23Abnormal spermatogenesis (HP:0008669)3.26176941
24Tubulointerstitial nephritis (HP:0001970)3.19024722
25Pancreatic fibrosis (HP:0100732)3.09831126
26Recurrent otitis media (HP:0000403)3.08859966
27Attenuation of retinal blood vessels (HP:0007843)2.93452855
28Gaze-evoked nystagmus (HP:0000640)2.91419111
29Medial flaring of the eyebrow (HP:0010747)2.81815551
30Inability to walk (HP:0002540)2.77294869
31Facial diplegia (HP:0001349)2.66109695
32Hyperventilation (HP:0002883)2.63108985
33Tubulointerstitial abnormality (HP:0001969)2.61955454
34Congenital, generalized hypertrichosis (HP:0004540)2.61945816
35Cerebellar dysplasia (HP:0007033)2.61651789
36Azoospermia (HP:0000027)2.58360201
37Cystic liver disease (HP:0006706)2.56460696
38Abolished electroretinogram (ERG) (HP:0000550)2.45668786
39Congenital sensorineural hearing impairment (HP:0008527)2.44885159
40Congenital stationary night blindness (HP:0007642)2.44044306
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.43666120
42Tubular atrophy (HP:0000092)2.42457640
43Decreased circulating renin level (HP:0003351)2.39513176
44Hyperinsulinemic hypoglycemia (HP:0000825)2.38632553
45Congenital hepatic fibrosis (HP:0002612)2.38151400
46Hypothermia (HP:0002045)2.35995948
47Gonadotropin excess (HP:0000837)2.33570088
48Abnormality of the renal cortex (HP:0011035)2.33250473
49Bony spicule pigmentary retinopathy (HP:0007737)2.32534097
50Postaxial foot polydactyly (HP:0001830)2.25865448
51Renal dysplasia (HP:0000110)2.25050549
52Male pseudohermaphroditism (HP:0000037)2.22589840
53Furrowed tongue (HP:0000221)2.20836249
54Insulin-resistant diabetes mellitus (HP:0000831)2.19017444
55Pancreatic islet-cell hyperplasia (HP:0004510)2.15957451
56Progressive cerebellar ataxia (HP:0002073)2.14584673
57Intestinal atresia (HP:0011100)2.14323953
58Stomach cancer (HP:0012126)2.14309055
59Constricted visual fields (HP:0001133)2.14171658
60True hermaphroditism (HP:0010459)2.12949424
61Clumsiness (HP:0002312)2.12366525
62Genital tract atresia (HP:0001827)2.11756620
63Median cleft lip (HP:0000161)2.11156337
64Degeneration of anterior horn cells (HP:0002398)2.10931614
65Abnormality of the anterior horn cell (HP:0006802)2.10931614
66Anencephaly (HP:0002323)2.10409443
67Tubulointerstitial fibrosis (HP:0005576)2.07268988
68Absent speech (HP:0001344)2.07127249
69Protruding tongue (HP:0010808)2.07126710
70Abnormality of the lower motor neuron (HP:0002366)2.05362609
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04829373
72Abnormality of alanine metabolism (HP:0010916)2.04829373
73Hyperalaninemia (HP:0003348)2.04829373
74Pancreatic cysts (HP:0001737)2.03979504
75Abnormal drinking behavior (HP:0030082)2.03576267
76Polydipsia (HP:0001959)2.03576267
77Abnormal biliary tract physiology (HP:0012439)2.02855371
78Bile duct proliferation (HP:0001408)2.02855371
79Chronic sinusitis (HP:0011109)2.02657808
80Papillary thyroid carcinoma (HP:0002895)2.00954424
81Sclerocornea (HP:0000647)2.00323189
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7142033
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.99386346
84Atonic seizures (HP:0010819)1.98211072
85Facial cleft (HP:0002006)1.97262727
86Widely spaced teeth (HP:0000687)1.96050377
87Vaginal atresia (HP:0000148)1.92971989
88Febrile seizures (HP:0002373)1.90826447
89Chronic hepatic failure (HP:0100626)1.90771318
90Abnormal rod and cone electroretinograms (HP:0008323)1.90697490
91Abnormality of dental color (HP:0011073)1.90652019
92Fair hair (HP:0002286)1.88637209
93Fibular hypoplasia (HP:0003038)1.87735762
94Ectopic kidney (HP:0000086)1.84639282
9511 pairs of ribs (HP:0000878)1.81803150
96Tongue fasciculations (HP:0001308)1.81707609
97Abnormality of macular pigmentation (HP:0008002)1.81625257
98Thyroid-stimulating hormone excess (HP:0002925)1.81045556
99Amelogenesis imperfecta (HP:0000705)1.80108958
100Keratoconus (HP:0000563)1.79466774
101Increased corneal curvature (HP:0100692)1.79466774
102Sloping forehead (HP:0000340)1.78553165
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77412508
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75641155
105Nephropathy (HP:0000112)1.75003939
106Hypomagnesemia (HP:0002917)1.74309885
107Stomatitis (HP:0010280)1.74275217
108Symptomatic seizures (HP:0011145)1.73581432
109Occipital encephalocele (HP:0002085)1.73261503
110Impulsivity (HP:0100710)1.72746912
111Astigmatism (HP:0000483)1.71991435
112Hyperglycinemia (HP:0002154)1.71524473
113Spontaneous abortion (HP:0005268)1.70667043
114Abnormality of renal excretion (HP:0011036)1.70083636
115Oculomotor apraxia (HP:0000657)1.69591455
116Hypoproteinemia (HP:0003075)1.69510476
117Dyskinesia (HP:0100660)1.69077322
118J-shaped sella turcica (HP:0002680)1.69053178
119Amyotrophic lateral sclerosis (HP:0007354)1.68303493
120Retinitis pigmentosa (HP:0000510)1.68215028
121Genetic anticipation (HP:0003743)1.68180893
122Enlarged kidneys (HP:0000105)1.67858050
123Hypoglycemic seizures (HP:0002173)1.66637350
124Small hand (HP:0200055)1.66284556
125Ketoacidosis (HP:0001993)1.65489964
126Congenital primary aphakia (HP:0007707)1.64618559
127Large for gestational age (HP:0001520)1.64528658
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63502012
129Short thorax (HP:0010306)1.62522252
130Postaxial hand polydactyly (HP:0001162)1.60694661
131Pigmentary retinal degeneration (HP:0001146)1.60478438
132Adrenal hypoplasia (HP:0000835)1.60245764
133Poor coordination (HP:0002370)1.60226414
134Photophobia (HP:0000613)1.60004682
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58464516
136Absent frontal sinuses (HP:0002688)1.57169392
137Microglossia (HP:0000171)1.56977344
138Gait imbalance (HP:0002141)1.55330885
139Stage 5 chronic kidney disease (HP:0003774)1.55218236
140Upper motor neuron abnormality (HP:0002127)1.54834273
141Impaired proprioception (HP:0010831)1.54458822
142Short ribs (HP:0000773)1.54141280
143Hyperkalemia (HP:0002153)1.51516061
144Retinal atrophy (HP:0001105)1.50348545
145Bifid tongue (HP:0010297)1.50293287
146Muscle fibrillation (HP:0010546)1.49916449
147Type II lissencephaly (HP:0007260)1.49900318
148Abnormality of ocular smooth pursuit (HP:0000617)1.49218866
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46552563
150Breast carcinoma (HP:0003002)1.43449999
151Abnormal urine output (HP:0012590)1.42954726
152Abnormality of the intrinsic pathway (HP:0010989)1.40836187
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.39914249
154Nephrogenic diabetes insipidus (HP:0009806)1.37622021
155Polyuria (HP:0000103)1.35400282
156Hyperglycemia (HP:0003074)1.34790551
157Large eyes (HP:0001090)1.34420978
158Abnormal protein glycosylation (HP:0012346)1.32689021
159Abnormal glycosylation (HP:0012345)1.32689021
160Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.32689021
161Abnormal protein N-linked glycosylation (HP:0012347)1.32689021
162Limb ataxia (HP:0002070)1.28266501
163Acute myeloid leukemia (HP:0004808)1.27498043
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.27366754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.45590455
2PDK37.45590455
3PDK24.54694144
4PRKD33.75707898
5MAPK153.34833555
6PASK3.07994550
7TESK12.89451855
8MAP4K22.70551821
9WNK42.67078265
10NUAK12.48141820
11PTK2B2.16377846
12INSRR2.00412412
13TAOK31.96528623
14NEK11.92857300
15ADRBK21.88559830
16TRIM281.87913780
17PNCK1.68190135
18PLK41.66368957
19GRK11.53014905
20STK38L1.49686185
21NEK21.46524520
22TNIK1.44505758
23ERBB31.39202183
24ICK1.33737616
25STK31.33091074
26IRAK11.28944203
27STK381.26701709
28CDC71.25805973
29DYRK31.24949367
30OXSR11.24435751
31STK391.20795358
32IRAK31.18829621
33NLK1.17974619
34MUSK1.17197577
35MST41.14673573
36TTK1.14112520
37TGFBR11.12165889
38MAPK131.10632559
39PLK21.10138718
40ZAP701.08849296
41PINK11.06888035
42MAP3K41.06866737
43IRAK41.02392006
44AKT31.02197115
45MYLK1.00593922
46MAP4K10.99215530
47BRSK20.98993907
48MAP2K70.97373007
49OBSCN0.96837042
50CHEK20.95498171
51FER0.94105532
52ATR0.92421756
53MAP3K60.85520601
54PDK10.85265164
55LATS10.84794200
56HIPK20.83513625
57CDK120.81481467
58CSNK1G10.80469684
59WNK10.79682822
60PRKCE0.79652376
61ADRBK10.78941201
62NTRK30.75457197
63DAPK20.74514124
64CASK0.73485600
65ATM0.72620597
66CSNK1G20.72364581
67PAK30.72060170
68BMPR1B0.71000302
69CSNK1A1L0.68527495
70CSNK1G30.68460069
71CHEK10.67995149
72FRK0.65810558
73TIE10.64512536
74JAK30.62765179
75MKNK20.62512670
76TEC0.61946107
77PRKCQ0.61826162
78PIK3CG0.60995724
79DYRK1B0.60974333
80EEF2K0.59998104
81KIT0.59990692
82CAMK1G0.58037625
83WEE10.57969683
84BTK0.55359711
85TNK20.54735842
86WNK30.53908646
87FGFR20.53427567
88BRAF0.53291281
89BLK0.50669687
90GRK60.50631781
91CCNB10.48210202
92EPHA40.47956984
93BCR0.45885822
94PRKAA10.45847409
95RPS6KB10.44301752
96SYK0.43578829
97GRK50.43354000
98MARK20.43205376
99IKBKB0.42856408
100IGF1R0.42622803
101MAP2K60.42182988
102PDGFRB0.42100412
103CDK30.41654078
104SGK20.41580726
105TXK0.40532403
106PRKACB0.40313314
107GRK70.40038935
108ERBB40.39382801
109MAPKAPK30.38799233
110TRPM70.37099031
111PLK10.37077140
112MELK0.37002155
113PRKG10.36870481
114EGFR0.36822522
115IRAK20.36545844
116CAMK2A0.35936432
117TAOK10.35886117
118TLK10.35517189
119VRK10.35427599
120FLT30.34627687
121PIK3CA0.34141639
122MARK30.33343627
123EIF2AK30.33340213
124RPS6KA50.32675177
125MKNK10.32305157
126PRKCG0.32208488
127ITK0.32091582
128PBK0.29790646
129CHUK0.29118808
130PKN10.28736444
131MAPKAPK50.28517169
132CSNK1D0.27281482
133PRKACA0.26932090
134PRKD20.26551293
135CSNK1A10.26477644
136CDK80.25971039
137ACVR1B0.25848146
138MTOR0.25165679
139ERN10.24993817
140BRSK10.24474391
141NEK60.23362147
142PRKG20.22979921
143MAP3K10.22720906
144MAPK110.21902748
145SCYL20.21400416
146PDPK10.21328296
147PRKDC0.21046727
148STK240.20663436
149CSF1R0.19009838
150BMPR20.18446117
151CDC42BPA0.18243645
152JAK10.17262298
153LYN0.17148800
154CSK0.16453870
155ZAK0.15838545
156MAP3K20.15824052
157MAPK140.15580248
158CDK20.14232314
159CDK90.14161667
160CDK10.13760562
161MAP3K50.13233566
162MAPK100.12216783

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.18986670
2Protein export_Homo sapiens_hsa030603.60149102
3Vitamin B6 metabolism_Homo sapiens_hsa007503.50329409
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.48439935
5Basal transcription factors_Homo sapiens_hsa030223.27797230
6Butanoate metabolism_Homo sapiens_hsa006503.08511612
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77680636
8Fanconi anemia pathway_Homo sapiens_hsa034602.74176620
9Phototransduction_Homo sapiens_hsa047442.50730743
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46046782
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.45052080
12Tryptophan metabolism_Homo sapiens_hsa003802.43992324
13Linoleic acid metabolism_Homo sapiens_hsa005912.39547582
14Nitrogen metabolism_Homo sapiens_hsa009102.38493934
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37244148
16Selenocompound metabolism_Homo sapiens_hsa004502.33299141
17Glucagon signaling pathway_Homo sapiens_hsa049222.20399626
18Dorso-ventral axis formation_Homo sapiens_hsa043202.19483634
19Olfactory transduction_Homo sapiens_hsa047402.06492670
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.04258312
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95710680
22Pentose phosphate pathway_Homo sapiens_hsa000301.94735809
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88591823
24Pyruvate metabolism_Homo sapiens_hsa006201.84509251
25N-Glycan biosynthesis_Homo sapiens_hsa005101.77852360
26Homologous recombination_Homo sapiens_hsa034401.77050957
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73022933
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.70376032
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69596504
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68736851
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67316809
32Insulin secretion_Homo sapiens_hsa049111.65929030
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65351027
34RNA degradation_Homo sapiens_hsa030181.62537440
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.60410784
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59419746
37Sulfur metabolism_Homo sapiens_hsa009201.57956493
38Antigen processing and presentation_Homo sapiens_hsa046121.52643251
39Nicotine addiction_Homo sapiens_hsa050331.52365100
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52188188
41Other glycan degradation_Homo sapiens_hsa005111.41456516
42Propanoate metabolism_Homo sapiens_hsa006401.39649028
43Chemical carcinogenesis_Homo sapiens_hsa052041.34311080
44Regulation of autophagy_Homo sapiens_hsa041401.31212499
45Renin-angiotensin system_Homo sapiens_hsa046141.25701458
46Salivary secretion_Homo sapiens_hsa049701.22028335
47ABC transporters_Homo sapiens_hsa020101.20669172
48RNA transport_Homo sapiens_hsa030131.19606526
49Ether lipid metabolism_Homo sapiens_hsa005651.17623626
50Oocyte meiosis_Homo sapiens_hsa041141.16756189
51mRNA surveillance pathway_Homo sapiens_hsa030151.15677586
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13663631
53Cell cycle_Homo sapiens_hsa041101.12940462
54Asthma_Homo sapiens_hsa053101.09964179
55One carbon pool by folate_Homo sapiens_hsa006701.08473619
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06762396
57Circadian entrainment_Homo sapiens_hsa047131.06203525
58Type I diabetes mellitus_Homo sapiens_hsa049401.04567185
59Legionellosis_Homo sapiens_hsa051341.03751684
60beta-Alanine metabolism_Homo sapiens_hsa004101.03147944
61Morphine addiction_Homo sapiens_hsa050321.01724330
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00113077
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.99685666
64Peroxisome_Homo sapiens_hsa041460.98727812
65Inositol phosphate metabolism_Homo sapiens_hsa005620.97497010
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97123140
67Fatty acid degradation_Homo sapiens_hsa000710.96101728
68Circadian rhythm_Homo sapiens_hsa047100.92693324
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91305198
70Calcium signaling pathway_Homo sapiens_hsa040200.91213428
71Serotonergic synapse_Homo sapiens_hsa047260.89784595
72Type II diabetes mellitus_Homo sapiens_hsa049300.87510263
73Purine metabolism_Homo sapiens_hsa002300.85695708
74Lysine degradation_Homo sapiens_hsa003100.84974190
75Amphetamine addiction_Homo sapiens_hsa050310.84862590
76Taste transduction_Homo sapiens_hsa047420.83891769
77RNA polymerase_Homo sapiens_hsa030200.83274768
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81726397
79Retinol metabolism_Homo sapiens_hsa008300.78560882
80Fatty acid biosynthesis_Homo sapiens_hsa000610.78483921
81Non-homologous end-joining_Homo sapiens_hsa034500.78427196
82Platelet activation_Homo sapiens_hsa046110.76944144
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76786022
84Collecting duct acid secretion_Homo sapiens_hsa049660.75511062
85Glycerolipid metabolism_Homo sapiens_hsa005610.74733579
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74729922
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74200667
88GABAergic synapse_Homo sapiens_hsa047270.73608277
89Fatty acid metabolism_Homo sapiens_hsa012120.72427306
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71671028
91Huntingtons disease_Homo sapiens_hsa050160.71145776
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70403755
93Fatty acid elongation_Homo sapiens_hsa000620.70343290
94Herpes simplex infection_Homo sapiens_hsa051680.69272129
95Arachidonic acid metabolism_Homo sapiens_hsa005900.68096674
96Vitamin digestion and absorption_Homo sapiens_hsa049770.67571990
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65372975
98Prolactin signaling pathway_Homo sapiens_hsa049170.63763536
99Ovarian steroidogenesis_Homo sapiens_hsa049130.63025526
100Gastric acid secretion_Homo sapiens_hsa049710.62577213
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61888078
102Histidine metabolism_Homo sapiens_hsa003400.59794362
103B cell receptor signaling pathway_Homo sapiens_hsa046620.58357841
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57657241
105Glutamatergic synapse_Homo sapiens_hsa047240.57390504
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.55946408
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.53710264
108Fructose and mannose metabolism_Homo sapiens_hsa000510.53325057
109Sphingolipid metabolism_Homo sapiens_hsa006000.52763668
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50181483
111Estrogen signaling pathway_Homo sapiens_hsa049150.48644544
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.47909037
113Hematopoietic cell lineage_Homo sapiens_hsa046400.47639003
114Thyroid hormone synthesis_Homo sapiens_hsa049180.47275651
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45131171
116p53 signaling pathway_Homo sapiens_hsa041150.43808666
117Measles_Homo sapiens_hsa051620.43780591
118Insulin resistance_Homo sapiens_hsa049310.43566395
119Base excision repair_Homo sapiens_hsa034100.42403600
120Glutathione metabolism_Homo sapiens_hsa004800.42155259
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40391279
122Graft-versus-host disease_Homo sapiens_hsa053320.40084955
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39512501
124Viral carcinogenesis_Homo sapiens_hsa052030.38960989
125Steroid biosynthesis_Homo sapiens_hsa001000.38767039
126Cocaine addiction_Homo sapiens_hsa050300.38541517
127Mineral absorption_Homo sapiens_hsa049780.38458219
128Caffeine metabolism_Homo sapiens_hsa002320.38380775
129Autoimmune thyroid disease_Homo sapiens_hsa053200.37110404
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36751665
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.36664425
132cAMP signaling pathway_Homo sapiens_hsa040240.32696578
133Renin secretion_Homo sapiens_hsa049240.32550169
134Oxytocin signaling pathway_Homo sapiens_hsa049210.32415869
135Influenza A_Homo sapiens_hsa051640.32323086
136Mismatch repair_Homo sapiens_hsa034300.32280687
137Pancreatic secretion_Homo sapiens_hsa049720.30970187
138AMPK signaling pathway_Homo sapiens_hsa041520.28777235
139Nucleotide excision repair_Homo sapiens_hsa034200.27200308
140Long-term potentiation_Homo sapiens_hsa047200.24981568
141Pyrimidine metabolism_Homo sapiens_hsa002400.24019461
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23331763
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22607868
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.22505892
145Fat digestion and absorption_Homo sapiens_hsa049750.22044722
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21905069
147Lysosome_Homo sapiens_hsa041420.21860896
148Osteoclast differentiation_Homo sapiens_hsa043800.20760731
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19468955
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.19420234
151Metabolic pathways_Homo sapiens_hsa011000.19409297
152Epstein-Barr virus infection_Homo sapiens_hsa051690.19244207
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18784556
154DNA replication_Homo sapiens_hsa030300.18365054
155Toxoplasmosis_Homo sapiens_hsa051450.17640287
156PPAR signaling pathway_Homo sapiens_hsa033200.17393263
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16071431
158HTLV-I infection_Homo sapiens_hsa051660.15639432
159Vascular smooth muscle contraction_Homo sapiens_hsa042700.15034367

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