CCBE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.25481930
2doxorubicin metabolic process (GO:0044598)7.25481930
3daunorubicin metabolic process (GO:0044597)7.25481930
4chondrocyte proliferation (GO:0035988)5.16798585
5neuron projection extension involved in neuron projection guidance (GO:1902284)5.07255074
6axon extension involved in axon guidance (GO:0048846)5.07255074
7detection of molecule of bacterial origin (GO:0032490)4.35991866
8aminoglycoside antibiotic metabolic process (GO:0030647)4.30153329
9mesenchymal-epithelial cell signaling (GO:0060638)4.18904116
10cellular response to interferon-alpha (GO:0035457)4.10177775
11negative regulation of nitric-oxide synthase activity (GO:0051001)4.07332022
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.04670745
13cell migration involved in heart development (GO:0060973)4.00495996
14metanephric mesenchyme development (GO:0072075)3.92271099
15dermatan sulfate biosynthetic process (GO:0030208)3.84210641
16response to pheromone (GO:0019236)3.68272272
17endocardial cushion development (GO:0003197)3.66732643
18mesodermal cell differentiation (GO:0048333)3.63503768
19substrate-dependent cell migration (GO:0006929)3.54636620
20sequestering of extracellular ligand from receptor (GO:0035581)3.53326319
21positive regulation of cardiac muscle cell differentiation (GO:2000727)3.46393062
22collagen fibril organization (GO:0030199)3.45218260
23dermatan sulfate metabolic process (GO:0030205)3.44888676
24cell adhesion mediated by integrin (GO:0033627)3.44708956
25regulation of hippo signaling (GO:0035330)3.37600199
26kidney mesenchyme development (GO:0072074)3.37040565
27positive regulation of male gonad development (GO:2000020)3.35084731
28heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.34631490
29behavioral response to nicotine (GO:0035095)3.34302145
30regulation of chemokine secretion (GO:0090196)3.31117580
31cell proliferation in forebrain (GO:0021846)3.28646901
32blood vessel maturation (GO:0001955)3.25719313
33pericardium development (GO:0060039)3.25174308
34extracellular matrix assembly (GO:0085029)3.24506972
35cellular response to vitamin (GO:0071295)3.23949737
36response to gravity (GO:0009629)3.22559620
37estrogen biosynthetic process (GO:0006703)3.20576909
38negative chemotaxis (GO:0050919)3.17849319
39positive regulation of fatty acid oxidation (GO:0046321)3.15977966
40positive regulation of gastrulation (GO:2000543)3.14658070
41regulation of male gonad development (GO:2000018)3.13406338
42regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.12789919
43ganglion development (GO:0061548)3.12164980
44regulation of axon extension involved in axon guidance (GO:0048841)3.11875752
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.10820011
46regulation of organ formation (GO:0003156)3.09024913
47middle ear morphogenesis (GO:0042474)3.07933245
48negative regulation of cardiac muscle tissue development (GO:0055026)3.06864796
49positive regulation of chemokine secretion (GO:0090197)3.05691841
50detection of external biotic stimulus (GO:0098581)3.05394005
51negative regulation of fatty acid transport (GO:2000192)3.03419737
52positive regulation of protein autophosphorylation (GO:0031954)3.00862554
53outer ear morphogenesis (GO:0042473)2.99463317
54epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.97607222
55type B pancreatic cell proliferation (GO:0044342)2.97422815
56negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.97394153
57paraxial mesoderm development (GO:0048339)2.96271818
58extracellular regulation of signal transduction (GO:1900115)2.95168871
59extracellular negative regulation of signal transduction (GO:1900116)2.95168871
60regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.94628739
61negative regulation of keratinocyte proliferation (GO:0010839)2.93975772
62cell proliferation involved in metanephros development (GO:0072203)2.93929781
63cell migration involved in sprouting angiogenesis (GO:0002042)2.92351453
64cell differentiation involved in metanephros development (GO:0072202)2.90596441
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89601705
66cellular response to vitamin D (GO:0071305)2.89488957
67response to redox state (GO:0051775)2.88049201
68heparin metabolic process (GO:0030202)2.87265535
69heparin biosynthetic process (GO:0030210)2.87265535
70fibroblast migration (GO:0010761)2.86470959
71wound healing, spreading of epidermal cells (GO:0035313)2.85206819
72organ induction (GO:0001759)2.83953837
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.83452852
74response to interferon-alpha (GO:0035455)2.81872142
75tooth mineralization (GO:0034505)2.80283169
76negative regulation of BMP signaling pathway (GO:0030514)2.79501699
77pharyngeal system development (GO:0060037)2.79045734
78mesenchymal cell differentiation involved in kidney development (GO:0072161)2.78770367
79mesenchymal cell differentiation involved in renal system development (GO:2001012)2.78770367
80head development (GO:0060322)2.78465382
81regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77785875
82* lymphangiogenesis (GO:0001946)2.77708795
83virion attachment to host cell (GO:0019062)2.76101709
84adhesion of symbiont to host cell (GO:0044650)2.76101709
85cell proliferation involved in kidney development (GO:0072111)2.74927922
86protein localization to cell surface (GO:0034394)2.73404961
87negative regulation of protein localization to cell surface (GO:2000009)2.73107728
88detection of biotic stimulus (GO:0009595)2.71774818
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71721824
90artery development (GO:0060840)2.70588270
91regulation of interleukin-8 secretion (GO:2000482)2.67553631
92positive regulation of macrophage activation (GO:0043032)2.66859866
93embryonic forelimb morphogenesis (GO:0035115)2.66461511
94inner ear receptor cell development (GO:0060119)2.66085356
95protein polyglutamylation (GO:0018095)2.65796928
96lateral ventricle development (GO:0021670)2.64892793
97lung morphogenesis (GO:0060425)2.64276880
98glomerular basement membrane development (GO:0032836)2.63629590
99endodermal cell differentiation (GO:0035987)2.63622200
100hippo signaling (GO:0035329)2.63021120
101proteoglycan biosynthetic process (GO:0030166)2.62005554
102negative regulation of axon guidance (GO:1902668)2.58562040
103negative regulation of activin receptor signaling pathway (GO:0032926)2.57686084
104bone remodeling (GO:0046849)2.57563171
105cartilage morphogenesis (GO:0060536)2.57434693
106regulation of integrin-mediated signaling pathway (GO:2001044)2.56186929
107protein heterotrimerization (GO:0070208)2.55969230
108endothelial cell morphogenesis (GO:0001886)2.55662794
109prostate gland growth (GO:0060736)2.55222701
110negative regulation of leukocyte chemotaxis (GO:0002689)2.53964817
111regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53470845
112hepatocyte differentiation (GO:0070365)2.52798817
113ventricular septum development (GO:0003281)2.52681639
114regulation of plasminogen activation (GO:0010755)2.50698349
115regulation of cardiac muscle cell differentiation (GO:2000725)2.50247321
116mesenchymal cell differentiation (GO:0048762)2.50096809
117negative regulation of JAK-STAT cascade (GO:0046426)2.49961359
118ovulation cycle (GO:0042698)2.49895843
119regulation of type B pancreatic cell apoptotic process (GO:2000674)2.48690104
120estrogen metabolic process (GO:0008210)2.46986974
121pattern specification involved in kidney development (GO:0061004)2.46630373
122negative regulation of stem cell proliferation (GO:2000647)2.46188901
123post-embryonic morphogenesis (GO:0009886)2.45907432
124replicative senescence (GO:0090399)2.45759180
125heparan sulfate proteoglycan metabolic process (GO:0030201)2.44531828
126facial nerve structural organization (GO:0021612)2.44089172
127anterior/posterior axis specification, embryo (GO:0008595)2.42508556
128positive regulation of catecholamine secretion (GO:0033605)2.42296878
129positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41232833
130parturition (GO:0007567)2.41175484
131sulfation (GO:0051923)2.40274124
132respiratory tube development (GO:0030323)2.39393500
133positive regulation of cartilage development (GO:0061036)2.38669845
134sulfate transmembrane transport (GO:1902358)2.38642841
135forelimb morphogenesis (GO:0035136)2.38442285
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38365867
137dopaminergic neuron differentiation (GO:0071542)2.37712909
138embryonic camera-type eye morphogenesis (GO:0048596)2.37415395
139negative regulation of chondrocyte differentiation (GO:0032331)2.36982213
140retinal cone cell development (GO:0046549)2.36649636
141embryonic skeletal joint morphogenesis (GO:0060272)2.36641883
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.36045533
143regulation of keratinocyte proliferation (GO:0010837)2.35557491
144metanephros development (GO:0001656)2.35116396
145regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35069496
146negative regulation of systemic arterial blood pressure (GO:0003085)2.35042636
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.34771823
148skin morphogenesis (GO:0043589)2.34469774
149positive regulation of cardiac muscle tissue development (GO:0055025)2.34037566
150lung vasculature development (GO:0060426)2.33154715
151synaptic vesicle docking involved in exocytosis (GO:0016081)2.33102750
152neural crest cell development (GO:0014032)2.31783988
153positive regulation of CREB transcription factor activity (GO:0032793)2.31783907
154vascular endothelial growth factor signaling pathway (GO:0038084)2.31383200
155glomerulus development (GO:0032835)2.30707250
156regulation of integrin activation (GO:0033623)2.30576176
157positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29403905
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.28739016
159mesonephros development (GO:0001823)2.27509803
160apoptotic cell clearance (GO:0043277)2.26726675
161negative regulation of mast cell activation (GO:0033004)2.24285294
162regulation of axon guidance (GO:1902667)2.23951651
163positive regulation of cellular amide metabolic process (GO:0034250)2.23531576
164smooth muscle tissue development (GO:0048745)2.22829205
165embryonic cranial skeleton morphogenesis (GO:0048701)2.22648534
166iron ion import (GO:0097286)2.22068024
167bone trabecula formation (GO:0060346)2.20623273
168positive regulation of heat generation (GO:0031652)2.20339579
169regulation of fever generation (GO:0031620)2.20291919
170positive regulation of natural killer cell differentiation (GO:0032825)2.19544405
171embryonic camera-type eye development (GO:0031076)2.19467181
172collagen catabolic process (GO:0030574)2.19267510
173regulation of mononuclear cell migration (GO:0071675)2.18730327
174collagen metabolic process (GO:0032963)2.17367835
175diaphragm development (GO:0060539)2.17306946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.63324923
2* GBX2_23144817_ChIP-Seq_PC3_Human2.69831084
3ZNF274_21170338_ChIP-Seq_K562_Hela2.62405575
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.58464492
5EZH2_22144423_ChIP-Seq_EOC_Human2.53063611
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39791960
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.38172263
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34283128
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23151205
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14805029
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.13742140
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10315300
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03968149
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.03639966
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97366618
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95268661
17CJUN_26792858_Chip-Seq_BT549_Human1.91570064
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.89282365
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85247422
20* EED_16625203_ChIP-ChIP_MESCs_Mouse1.81397618
21VDR_22108803_ChIP-Seq_LS180_Human1.74689543
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70925348
23* TP53_18474530_ChIP-ChIP_U2OS_Human1.69393334
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68233810
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66449978
26* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66449978
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65548245
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63584150
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63207842
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62871648
31* BRD4_25478319_ChIP-Seq_HGPS_Human1.62148728
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60055866
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57928322
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.56862098
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56413280
36FUS_26573619_Chip-Seq_HEK293_Human1.55072037
37* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51171900
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.48722633
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47556904
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47358593
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47024558
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.46260696
43EWS_26573619_Chip-Seq_HEK293_Human1.44542692
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.44044435
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42562522
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41508500
47TP53_16413492_ChIP-PET_HCT116_Human1.41278137
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39104873
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39104873
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38499762
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38441078
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37805026
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37608762
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36847804
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36204136
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35974578
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35695278
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.35365892
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35106497
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34584722
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.33790431
62SMAD4_21799915_ChIP-Seq_A2780_Human1.33260183
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.32424892
64BCAT_22108803_ChIP-Seq_LS180_Human1.32158894
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31803912
66STAT3_23295773_ChIP-Seq_U87_Human1.31109711
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.30937861
68RXR_22108803_ChIP-Seq_LS180_Human1.30921865
69VDR_24787735_ChIP-Seq_THP-1_Human1.29810903
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.29458581
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28860772
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27671606
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.27268042
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.26946701
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25731379
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.24023840
77* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23954254
78KDM2B_26808549_Chip-Seq_REH_Human1.22138152
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21727656
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21001209
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.20645205
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.20514726
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20330284
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19699391
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19648637
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19648637
87AR_21572438_ChIP-Seq_LNCaP_Human1.19426653
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19075971
89P300_19829295_ChIP-Seq_ESCs_Human1.18718342
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18197100
91DROSHA_22980978_ChIP-Seq_HELA_Human1.17533592
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17394887
93AHR_22903824_ChIP-Seq_MCF-7_Human1.17262132
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.17247844
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17163248
96CBP_20019798_ChIP-Seq_JUKART_Human1.17163248
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16370282
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15272870
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14895692
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.14657276
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.14470559
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13542432
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13153261
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11229018
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.10936177
106* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10611499
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.10328975
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09686423
109* TCF4_23295773_ChIP-Seq_U87_Human1.09594711
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09589898
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08883155
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08676126
113SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08514155
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08007006
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07147329
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06718334
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06615814
118ER_23166858_ChIP-Seq_MCF-7_Human1.06461793
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.05417580
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05291352
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05194163
122P53_22387025_ChIP-Seq_ESCs_Mouse1.04780875
123SOX2_20726797_ChIP-Seq_SW620_Human1.04257547
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03921315
125* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03676895
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03179610
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03171348
128CDX2_20551321_ChIP-Seq_CACO-2_Human1.03159361
129AR_25329375_ChIP-Seq_VCAP_Human1.02887959
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01429724
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.00539451
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00269914
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00058995
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.99885230
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99336569
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98733709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.07726020
2MP0005503_abnormal_tendon_morphology4.49579774
3MP0005275_abnormal_skin_tensile3.57167647
4MP0003950_abnormal_plasma_membrane3.53610191
5MP0005257_abnormal_intraocular_pressure3.43011238
6MP0001542_abnormal_bone_strength3.06059225
7MP0008004_abnormal_stomach_pH2.68933148
8MP0003279_aneurysm2.46488548
9MP0000569_abnormal_digit_pigmentation2.45711244
10MP0009697_abnormal_copulation2.42212508
11MP0005623_abnormal_meninges_morphology2.26497091
12MP0000013_abnormal_adipose_tissue2.24030969
13MP0005171_absent_coat_pigmentation2.22011646
14MP0009250_abnormal_appendicular_skeleto2.21250154
15MP0000566_synostosis2.17954491
16MP0003941_abnormal_skin_development2.13495222
17MP0003705_abnormal_hypodermis_morpholog2.13156345
18MP0010368_abnormal_lymphatic_system2.09651854
19MP0001958_emphysema2.06283809
20MP0003942_abnormal_urinary_system1.98638377
21MP0002160_abnormal_reproductive_system1.96726344
22MP0005508_abnormal_skeleton_morphology1.95443332
23MP0003385_abnormal_body_wall1.93406407
24MP0001299_abnormal_eye_distance/1.71661738
25MP0009384_cardiac_valve_regurgitation1.68871361
26MP0003091_abnormal_cell_migration1.65992218
27MP0009053_abnormal_anal_canal1.64087653
28MP0000537_abnormal_urethra_morphology1.62655285
29MP0004134_abnormal_chest_morphology1.61971088
30MP0003283_abnormal_digestive_organ1.61961235
31MP0002060_abnormal_skin_morphology1.61361744
32MP0001346_abnormal_lacrimal_gland1.60467488
33MP0000534_abnormal_ureter_morphology1.57470599
34MP0003566_abnormal_cell_adhesion1.55995285
35MP0000049_abnormal_middle_ear1.55689910
36MP0004272_abnormal_basement_membrane1.55403143
37MP0003878_abnormal_ear_physiology1.44203768
38MP0005377_hearing/vestibular/ear_phenot1.44203768
39MP0001348_abnormal_lacrimal_gland1.43203073
40MP0005389_reproductive_system_phenotype1.42997080
41MP0000733_abnormal_muscle_development1.42739442
42MP0000163_abnormal_cartilage_morphology1.42340103
43MP0003045_fibrosis1.39739528
44MP0003115_abnormal_respiratory_system1.39554394
45MP0000681_abnormal_thyroid_gland1.37236130
46MP0002896_abnormal_bone_mineralization1.37167495
47MP0004885_abnormal_endolymph1.36283089
48MP0002998_abnormal_bone_remodeling1.36015145
49MP0003937_abnormal_limbs/digits/tail_de1.35148691
50MP0002115_abnormal_skeleton_extremities1.34378983
51MP0001879_abnormal_lymphatic_vessel1.30834051
52MP0005023_abnormal_wound_healing1.28854925
53MP0002113_abnormal_skeleton_development1.28339524
54MP0002109_abnormal_limb_morphology1.27868255
55MP0002234_abnormal_pharynx_morphology1.27307836
56MP0003755_abnormal_palate_morphology1.25505233
57MP0002177_abnormal_outer_ear1.25452406
58MP0005248_abnormal_Harderian_gland1.24326776
59MP0002108_abnormal_muscle_morphology1.23489944
60MP0005076_abnormal_cell_differentiation1.23268865
61MP0001177_atelectasis1.23179545
62MP0000767_abnormal_smooth_muscle1.21639079
63MP0002249_abnormal_larynx_morphology1.21430615
64MP0010386_abnormal_urinary_bladder1.19775900
65MP0002102_abnormal_ear_morphology1.18798062
66MP0010352_gastrointestinal_tract_polyps1.18440698
67MP0000427_abnormal_hair_cycle1.17667225
68MP0005390_skeleton_phenotype1.17411240
69MP0010030_abnormal_orbit_morphology1.16661733
70MP0000516_abnormal_urinary_system1.13566461
71MP0005367_renal/urinary_system_phenotyp1.13566461
72MP0000428_abnormal_craniofacial_morphol1.13055808
73MP0002295_abnormal_pulmonary_circulatio1.10986259
74MP0003122_maternal_imprinting1.09900912
75MP0000432_abnormal_head_morphology1.08649644
76MP0002116_abnormal_craniofacial_bone1.07389091
77MP0003935_abnormal_craniofacial_develop1.07120063
78MP0000858_altered_metastatic_potential1.06983076
79MP0001243_abnormal_dermal_layer1.04620887
80MP0002932_abnormal_joint_morphology1.01765545
81MP0002938_white_spotting1.01147985
82MP0003868_abnormal_feces_composition1.00837962
83MP0002282_abnormal_trachea_morphology0.99872817
84MP0005647_abnormal_sex_gland0.98947207
85MP0006072_abnormal_retinal_apoptosis0.98746421
86MP0002876_abnormal_thyroid_physiology0.97831337
87MP0002933_joint_inflammation0.97345623
88MP0002928_abnormal_bile_duct0.96800210
89MP0000627_abnormal_mammary_gland0.94527348
90MP0005197_abnormal_uvea_morphology0.94056981
91MP0002233_abnormal_nose_morphology0.93848077
92MP0001119_abnormal_female_reproductive0.93734409
93MP0000230_abnormal_systemic_arterial0.93163531
94MP0003795_abnormal_bone_structure0.93005225
95MP0003936_abnormal_reproductive_system0.92417035
96MP0001175_abnormal_lung_morphology0.92259261
97MP0002837_dystrophic_cardiac_calcinosis0.91833700
98MP0006292_abnormal_olfactory_placode0.91738639
99MP0006054_spinal_hemorrhage0.91510451
100MP0001270_distended_abdomen0.89905308
101MP0002254_reproductive_system_inflammat0.89096511
102MP0000538_abnormal_urinary_bladder0.87360480
103MP0000678_abnormal_parathyroid_gland0.87086601
104MP0005360_urolithiasis0.86759675
105MP0008775_abnormal_heart_ventricle0.84761482
106MP0002751_abnormal_autonomic_nervous0.83878657
107MP0001293_anophthalmia0.82892534
108MP0003252_abnormal_bile_duct0.82360136
109MP0000003_abnormal_adipose_tissue0.81979775
110MP0000750_abnormal_muscle_regeneration0.81041193
111MP0002168_other_aberrant_phenotype0.80746642
112MP0004133_heterotaxia0.80640704
113MP0002128_abnormal_blood_circulation0.79445377
114MP0005551_abnormal_eye_electrophysiolog0.78553064
115MP0000613_abnormal_salivary_gland0.76262222
116MP0001919_abnormal_reproductive_system0.74950648
117MP0005083_abnormal_biliary_tract0.74024555
118MP0005645_abnormal_hypothalamus_physiol0.73804948
119MP0009780_abnormal_chondrocyte_physiolo0.73067020
120MP0000762_abnormal_tongue_morphology0.71079059
121MP0000639_abnormal_adrenal_gland0.71047405
122MP0000749_muscle_degeneration0.70876019
123MP0004142_abnormal_muscle_tone0.69741561
124MP0002114_abnormal_axial_skeleton0.69512720
125MP0001614_abnormal_blood_vessel0.69348199
126MP0005595_abnormal_vascular_smooth0.69202749
127MP0002133_abnormal_respiratory_system0.68274319
128MP0005388_respiratory_system_phenotype0.68274319
129MP0003943_abnormal_hepatobiliary_system0.67988525
130MP0002925_abnormal_cardiovascular_devel0.67750283
131MP0002697_abnormal_eye_size0.67629184
132MP0005164_abnormal_response_to0.67430674
133MP0005620_abnormal_muscle_contractility0.66992986
134MP0001968_abnormal_touch/_nociception0.60976695
135MP0001986_abnormal_taste_sensitivity0.60426167
136MP0002089_abnormal_postnatal_growth/wei0.60409891
137MP0001661_extended_life_span0.59760368
138MP0003119_abnormal_digestive_system0.56549603
139MP0000759_abnormal_skeletal_muscle0.56402174

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.91324973
2Premature rupture of membranes (HP:0001788)4.66415734
3Follicular hyperkeratosis (HP:0007502)3.96829669
4Spinal cord lesions (HP:0100561)3.69633507
5Syringomyelia (HP:0003396)3.69633507
6Unilateral renal agenesis (HP:0000122)3.61254483
7Alopecia of scalp (HP:0002293)3.60111067
8Increased corneal curvature (HP:0100692)3.49431616
9Keratoconus (HP:0000563)3.49431616
10Aortic dissection (HP:0002647)3.43473413
11Shallow orbits (HP:0000586)3.35449636
12Atrophic scars (HP:0001075)3.27548473
13Soft skin (HP:0000977)3.25482207
14Type 1 muscle fiber predominance (HP:0003803)3.13683770
15Pancreatic fibrosis (HP:0100732)3.01746674
16Aortic aneurysm (HP:0004942)2.96594872
17Vertebral compression fractures (HP:0002953)2.91699886
18Cervical subluxation (HP:0003308)2.85797814
19Slender build (HP:0001533)2.77393110
20Fragile skin (HP:0001030)2.61722430
21Wrist flexion contracture (HP:0001239)2.60771664
22Neonatal short-limb short stature (HP:0008921)2.58855045
23Pancreatic cysts (HP:0001737)2.55663490
24Bilateral sensorineural hearing impairment (HP:0008619)2.52496472
25Aortic valve stenosis (HP:0001650)2.49418313
26Broad metatarsal (HP:0001783)2.48663831
27Bowel diverticulosis (HP:0005222)2.47285970
28True hermaphroditism (HP:0010459)2.44301536
29Mesomelia (HP:0003027)2.44189220
30Ankle contracture (HP:0006466)2.43721993
31Dilatation of the ascending aorta (HP:0005111)2.43041615
32Absent frontal sinuses (HP:0002688)2.39323073
33Bladder diverticulum (HP:0000015)2.33930795
34Prostate neoplasm (HP:0100787)2.33679591
35Type II lissencephaly (HP:0007260)2.33446315
36Decreased subcutaneous fat (HP:0001002)2.32302884
37Hypoventilation (HP:0002791)2.29527927
38Abnormality of the phalanges of the 2nd finger (HP:0009541)2.27482793
39Genu recurvatum (HP:0002816)2.24775478
40Cerebral aneurysm (HP:0004944)2.24306697
41Molar tooth sign on MRI (HP:0002419)2.22531652
42Abnormality of midbrain morphology (HP:0002418)2.22531652
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.21338203
44Short 1st metacarpal (HP:0010034)2.21338203
45Aortic regurgitation (HP:0001659)2.17643541
46Delayed gross motor development (HP:0002194)2.16605202
47Bell-shaped thorax (HP:0001591)2.14703123
48Abnormality of the nasal septum (HP:0000419)2.14552699
49Mitral stenosis (HP:0001718)2.14227299
50Vascular tortuosity (HP:0004948)2.12841866
51Short hallux (HP:0010109)2.11660453
52Redundant skin (HP:0001582)2.09616301
53Cardiovascular calcification (HP:0011915)2.08565498
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.08081367
55Wormian bones (HP:0002645)2.06784203
56Cheilitis (HP:0100825)2.06219258
57Enlarged penis (HP:0000040)2.05460505
58Blue sclerae (HP:0000592)2.05131927
59Elbow flexion contracture (HP:0002987)2.02590775
60Deviation of the hallux (HP:0010051)2.02275898
61Chronic hepatic failure (HP:0100626)2.01679446
62Absent eyelashes (HP:0000561)2.01606956
63Bulbous nose (HP:0000414)2.01577122
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.01332234
65Aplasia/Hypoplasia of the hallux (HP:0008362)2.01173845
66Hyperventilation (HP:0002883)2.01044658
67Radial bowing (HP:0002986)2.00258324
68Arterial tortuosity (HP:0005116)1.98567895
69Spondylolisthesis (HP:0003302)1.98498674
70* Coronal craniosynostosis (HP:0004440)1.96091658
71Abnormality of dentin (HP:0010299)1.95905456
72Nephronophthisis (HP:0000090)1.95240364
73Hyperphosphatemia (HP:0002905)1.94992980
74Peritonitis (HP:0002586)1.94595232
75Spinal rigidity (HP:0003306)1.93963796
76Reduced subcutaneous adipose tissue (HP:0003758)1.93691731
77Subacute progressive viral hepatitis (HP:0006572)1.93496017
78Tibial bowing (HP:0002982)1.93321026
79Abnormality of the 2nd finger (HP:0004100)1.92715148
80Abnormality of the right ventricle (HP:0001707)1.92613184
81Asymmetry of the thorax (HP:0001555)1.92136173
82Hallux valgus (HP:0001822)1.92119503
83Limited hip movement (HP:0008800)1.90392012
84Biconcave vertebral bodies (HP:0004586)1.88555981
85Congenital sensorineural hearing impairment (HP:0008527)1.88321061
86Microglossia (HP:0000171)1.88033830
87Osteolytic defects of the hand bones (HP:0009699)1.87704437
88Osteolytic defects of the phalanges of the hand (HP:0009771)1.87704437
89Synostosis of carpal bones (HP:0005048)1.87556758
90Chorioretinal atrophy (HP:0000533)1.86899027
91Aplasia involving bones of the upper limbs (HP:0009823)1.86738365
92Aplasia of the phalanges of the hand (HP:0009802)1.86738365
93Aplasia involving bones of the extremities (HP:0009825)1.86738365
94Pendular nystagmus (HP:0012043)1.86383209
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.86381525
96Fibular aplasia (HP:0002990)1.85373704
97Aplasia of the musculature (HP:0100854)1.85333577
98Abnormality of the middle phalanges of the toes (HP:0010183)1.84798553
99Ovoid vertebral bodies (HP:0003300)1.84047082
100Tubular atrophy (HP:0000092)1.83687048
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83593873
102Joint stiffness (HP:0001387)1.83425742
103Broad ribs (HP:0000885)1.82961124
104Large eyes (HP:0001090)1.82639937
105Abnormality of the 1st metacarpal (HP:0010009)1.81794109
106Recurrent corneal erosions (HP:0000495)1.80773803
107Short nail (HP:0001799)1.78103875
108Hip contracture (HP:0003273)1.76673251
109Abnormality of subcutaneous fat tissue (HP:0001001)1.76576622
110Knee flexion contracture (HP:0006380)1.76567574
111Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74656486
112Parakeratosis (HP:0001036)1.74325448
113Bradycardia (HP:0001662)1.74310779
114Buphthalmos (HP:0000557)1.74197430
115Neoplasm of the lung (HP:0100526)1.73555253
116Mitral regurgitation (HP:0001653)1.73461133
117Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72575958
118Entropion (HP:0000621)1.72564069
119Congenital, generalized hypertrichosis (HP:0004540)1.72494205
120Cystic liver disease (HP:0006706)1.71934691
121Mitral valve prolapse (HP:0001634)1.71223463
122Bowing of the arm (HP:0006488)1.70923426
123Bowed forearm bones (HP:0003956)1.70923426
124Narrow nasal bridge (HP:0000446)1.70745380
125Increased density of long bones (HP:0006392)1.68723293
126Abnormality of the frontal sinuses (HP:0002687)1.67744903
127Femoral bowing (HP:0002980)1.67122401
128Abnormality of the odontoid process (HP:0003310)1.65556030
129Absent/shortened dynein arms (HP:0200106)1.65214258
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.65214258
131Persistence of primary teeth (HP:0006335)1.65091911
132Long toe (HP:0010511)1.64027236
133Overgrowth (HP:0001548)1.63680202
134Joint laxity (HP:0001388)1.63471094
135Aneurysm (HP:0002617)1.63204348
136Wide anterior fontanel (HP:0000260)1.62104182
137Abnormal cortical bone morphology (HP:0003103)1.60998737
138Natal tooth (HP:0000695)1.60652872
139Bone pain (HP:0002653)1.59266084
140Hyperextensible skin (HP:0000974)1.58725147
141Tarsal synostosis (HP:0008368)1.58459426
142Bruising susceptibility (HP:0000978)1.58297020
143Advanced eruption of teeth (HP:0006288)1.57936266
144Absent eyebrow (HP:0002223)1.57862883
145Abnormality of the acetabulum (HP:0003170)1.57341676
146Vascular calcification (HP:0004934)1.57265603
147Delayed closure of the anterior fontanelle (HP:0001476)1.55061680
148Inguinal hernia (HP:0000023)1.54599947
149Long eyelashes (HP:0000527)1.54359284
150Craniofacial hyperostosis (HP:0004493)1.53904407
151Synostosis involving bones of the lower limbs (HP:0009138)1.50825187
152Synostosis involving bones of the feet (HP:0009140)1.50825187
153Accelerated skeletal maturation (HP:0005616)1.50801803
154Abnormal delivery (HP:0001787)1.49789446
155Delayed cranial suture closure (HP:0000270)1.48508535
156Morphological abnormality of the middle ear (HP:0008609)1.48101225
157Broad toe (HP:0001837)1.46798370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.88474947
2LATS14.98575467
3MYLK3.71750068
4SIK13.37516974
5GRK13.20581750
6ADRBK23.20309255
7EPHA23.00580744
8LIMK12.65331007
9TLK12.61599173
10CDK82.57363267
11DDR22.51352041
12SIK22.51019626
13PDGFRA2.17789207
14STK32.15599959
15CASK2.13334776
16LATS22.13283332
17STK38L2.08214193
18FRK2.03362730
19ADRBK12.01786277
20FER1.97972293
21CDK121.85854276
22EPHB21.79569694
23PRPF4B1.76694593
24TTN1.71651001
25NUAK11.68252343
26MAP3K141.65699959
27BMX1.62521186
28MUSK1.62021116
29WNK41.60542527
30INSRR1.60138823
31PINK11.54318575
32PTK2B1.53872799
33ERBB31.52197243
34NEK91.47902928
35TRPM71.45241268
36DMPK1.44637041
37ZAK1.43701041
38MOS1.35502231
39FLT31.31010127
40NEK21.25878771
41PTK21.24120761
42PAK41.23439099
43AKT31.22492711
44PRKD31.22447308
45PAK61.20843355
46MARK31.16972085
47EIF2AK21.14393973
48PAK21.10200241
49MAP4K21.07958264
50PIK3CG1.05097897
51GRK71.04107738
52PDGFRB1.04069714
53MELK1.03760586
54PLK21.02244654
55NTRK10.99297692
56MAPK70.96834539
57CAMKK20.96652421
58MAPK130.96028645
59CHUK0.95061972
60MAP2K10.94685238
61TGFBR20.93800321
62ACVR1B0.90998170
63GRK50.90342147
64RPS6KA40.88679078
65NTRK30.86292067
66PNCK0.85549127
67WNK30.84667250
68ERBB40.84398403
69EPHA30.77592496
70PIK3CA0.75477015
71PRKD20.74982397
72TIE10.73996173
73JAK10.73633007
74CSK0.72839095
75RPS6KA20.72412490
76STK390.70695518
77ERN10.66767916
78MAP2K70.65733129
79GSK3A0.65432516
80ROCK10.64367063
81CDC42BPA0.62149782
82STK380.61735372
83CAMK1D0.61159023
84CDK70.59039152
85STK160.57754489
86MAP2K20.55440684
87RPS6KA60.53539765
88DYRK20.52683835
89CDK90.52228448
90PHKG20.51561440
91PHKG10.51561440
92PRKCG0.51483947
93RIPK10.51295553
94EEF2K0.51066999
95FGFR30.50692738
96PRKCE0.50111316
97DAPK30.50074483
98TNK20.49787664
99PRKCH0.49626821
100MARK20.48014436
101BMPR1B0.47178700
102TAOK30.46923516
103TAOK20.46782933
104MTOR0.46197452
105CAMK2D0.45776965
106CAMK40.45595670
107VRK10.45163307
108SGK20.44393809
109CDK60.44109666
110AURKA0.43958431
111FGFR10.43928021
112DAPK20.43636165
113WNK10.43142901
114CAMK2A0.41938758
115MAPKAPK30.41562476
116INSR0.40133002
117TESK10.40041648
118PRKCI0.39427166
119MST1R0.38840877
120ILK0.36714244
121ROCK20.36500359
122BRSK20.36268560
123SGK10.35112277
124PIM20.34718758
125TRIB30.34113400
126CHEK20.34113008
127CAMK10.33421978
128KIT0.33292239
129IGF1R0.32884820
130PRKD10.32782617
131FGFR20.32653392
132ERBB20.32555107
133PRKCA0.31557135
134MAP3K90.31429803
135MAP3K130.29771937
136SRC0.29708294
137RPS6KC10.29103868
138RPS6KL10.29103868
139YES10.28877435
140STK240.28813436
141SGK30.28697428
142PRKAA20.28610520
143ABL20.28526727
144PLK30.28318672
145CAMKK10.27951587
146AKT10.27790039
147ABL10.27229508
148MAP3K70.26680867
149PTK60.26158734
150MAPK10.25711726
151MET0.24775409
152PAK30.22875755
153BCR0.22854621
154PKN20.22755888
155TGFBR10.19704782
156MARK10.19218166
157TBK10.19104316

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.48492333
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12392187
3Sulfur metabolism_Homo sapiens_hsa009202.01821143
4Adherens junction_Homo sapiens_hsa045201.94634649
5Focal adhesion_Homo sapiens_hsa045101.93007009
6Selenocompound metabolism_Homo sapiens_hsa004501.90881402
7Phototransduction_Homo sapiens_hsa047441.90863420
8Ovarian steroidogenesis_Homo sapiens_hsa049131.88201139
9Small cell lung cancer_Homo sapiens_hsa052221.81324582
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68210170
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63716195
12Melanoma_Homo sapiens_hsa052181.58415108
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.58323334
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57956779
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55810753
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54292054
17Malaria_Homo sapiens_hsa051441.54224358
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53289452
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49450556
20MicroRNAs in cancer_Homo sapiens_hsa052061.48206227
21Proteoglycans in cancer_Homo sapiens_hsa052051.46567797
22TNF signaling pathway_Homo sapiens_hsa046681.41977253
23Hippo signaling pathway_Homo sapiens_hsa043901.41513389
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39170222
25TGF-beta signaling pathway_Homo sapiens_hsa043501.37705580
26Insulin secretion_Homo sapiens_hsa049111.37660529
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36034639
28Axon guidance_Homo sapiens_hsa043601.34955959
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33296604
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26447559
31Amoebiasis_Homo sapiens_hsa051461.25855131
32Basal transcription factors_Homo sapiens_hsa030221.25776496
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24770865
34Dilated cardiomyopathy_Homo sapiens_hsa054141.22898418
35Viral myocarditis_Homo sapiens_hsa054161.22710655
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21106587
37Dorso-ventral axis formation_Homo sapiens_hsa043201.18951470
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17643725
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.17560754
40Prostate cancer_Homo sapiens_hsa052151.17190778
41Hematopoietic cell lineage_Homo sapiens_hsa046401.13894671
42PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12737329
43Wnt signaling pathway_Homo sapiens_hsa043101.11206495
44Glioma_Homo sapiens_hsa052141.08808978
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.08285682
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.07632417
47Salmonella infection_Homo sapiens_hsa051321.07610769
48Morphine addiction_Homo sapiens_hsa050321.06495044
49Caffeine metabolism_Homo sapiens_hsa002321.05784079
50Calcium signaling pathway_Homo sapiens_hsa040201.04254896
51Leishmaniasis_Homo sapiens_hsa051401.04254727
52Chronic myeloid leukemia_Homo sapiens_hsa052201.02064732
53Basal cell carcinoma_Homo sapiens_hsa052171.00669918
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99857342
55Taste transduction_Homo sapiens_hsa047420.97671128
56Glutamatergic synapse_Homo sapiens_hsa047240.97197284
57Legionellosis_Homo sapiens_hsa051340.96932522
58Linoleic acid metabolism_Homo sapiens_hsa005910.96768817
59Phagosome_Homo sapiens_hsa041450.96577932
60RNA polymerase_Homo sapiens_hsa030200.95234473
61Hepatitis B_Homo sapiens_hsa051610.94617537
62Rap1 signaling pathway_Homo sapiens_hsa040150.93783616
63Lysine degradation_Homo sapiens_hsa003100.93701174
64Tryptophan metabolism_Homo sapiens_hsa003800.93385462
65Bladder cancer_Homo sapiens_hsa052190.93235439
66Protein digestion and absorption_Homo sapiens_hsa049740.92308466
67Nicotine addiction_Homo sapiens_hsa050330.92077032
68Pancreatic cancer_Homo sapiens_hsa052120.91847340
69p53 signaling pathway_Homo sapiens_hsa041150.91583631
70Shigellosis_Homo sapiens_hsa051310.91159321
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90921831
72Endometrial cancer_Homo sapiens_hsa052130.89704392
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.89637711
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88509774
75Measles_Homo sapiens_hsa051620.88048186
76Fanconi anemia pathway_Homo sapiens_hsa034600.87610370
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.87047673
78One carbon pool by folate_Homo sapiens_hsa006700.86703615
79Tuberculosis_Homo sapiens_hsa051520.86429535
80Pathways in cancer_Homo sapiens_hsa052000.86149814
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85419351
82Toxoplasmosis_Homo sapiens_hsa051450.85093221
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84972462
84Cocaine addiction_Homo sapiens_hsa050300.84474640
85Circadian entrainment_Homo sapiens_hsa047130.82832955
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82793368
87ErbB signaling pathway_Homo sapiens_hsa040120.82785348
88Pertussis_Homo sapiens_hsa051330.82199323
89Osteoclast differentiation_Homo sapiens_hsa043800.81413879
90Influenza A_Homo sapiens_hsa051640.81232028
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80668605
92Serotonergic synapse_Homo sapiens_hsa047260.79647494
93Renin secretion_Homo sapiens_hsa049240.78035887
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77697912
95Complement and coagulation cascades_Homo sapiens_hsa046100.77514284
96Gap junction_Homo sapiens_hsa045400.77171484
97Salivary secretion_Homo sapiens_hsa049700.77068019
98Ras signaling pathway_Homo sapiens_hsa040140.75492283
99Rheumatoid arthritis_Homo sapiens_hsa053230.75379835
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74515469
101Chemical carcinogenesis_Homo sapiens_hsa052040.74257410
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74192827
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73871954
104GABAergic synapse_Homo sapiens_hsa047270.73563985
105HTLV-I infection_Homo sapiens_hsa051660.73558997
106Olfactory transduction_Homo sapiens_hsa047400.71996188
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71833614
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.71513602
109Melanogenesis_Homo sapiens_hsa049160.71454809
110Platelet activation_Homo sapiens_hsa046110.70064984
111Mineral absorption_Homo sapiens_hsa049780.70022410
112Prolactin signaling pathway_Homo sapiens_hsa049170.69881101
113Protein export_Homo sapiens_hsa030600.69257408
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69244033
115FoxO signaling pathway_Homo sapiens_hsa040680.68456593
116Hedgehog signaling pathway_Homo sapiens_hsa043400.66737699
117Nitrogen metabolism_Homo sapiens_hsa009100.66581257
118Oxytocin signaling pathway_Homo sapiens_hsa049210.66182034
119Cholinergic synapse_Homo sapiens_hsa047250.66068881
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65971899
121Colorectal cancer_Homo sapiens_hsa052100.65469745
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65098705
123Notch signaling pathway_Homo sapiens_hsa043300.63804238
124Retinol metabolism_Homo sapiens_hsa008300.63403067
125Herpes simplex infection_Homo sapiens_hsa051680.63061557
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61939910
127Apoptosis_Homo sapiens_hsa042100.59541569
128Dopaminergic synapse_Homo sapiens_hsa047280.59119985
129Renin-angiotensin system_Homo sapiens_hsa046140.57875381
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57305765
131African trypanosomiasis_Homo sapiens_hsa051430.55208426
132Arachidonic acid metabolism_Homo sapiens_hsa005900.54382802
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54135508
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52369165
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52077371
136Homologous recombination_Homo sapiens_hsa034400.51357719
137Tight junction_Homo sapiens_hsa045300.50337737
138Nucleotide excision repair_Homo sapiens_hsa034200.50245141
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49986504
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49663620
141Circadian rhythm_Homo sapiens_hsa047100.49147174
142Long-term depression_Homo sapiens_hsa047300.48673477
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.45978338
144Chemokine signaling pathway_Homo sapiens_hsa040620.45486906
145Sulfur relay system_Homo sapiens_hsa041220.44852344
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44559192
147Regulation of autophagy_Homo sapiens_hsa041400.44311633
148Gastric acid secretion_Homo sapiens_hsa049710.44000944
149cAMP signaling pathway_Homo sapiens_hsa040240.43682042
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43589988
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.43221638
152MAPK signaling pathway_Homo sapiens_hsa040100.42363423
153Fatty acid biosynthesis_Homo sapiens_hsa000610.40917185
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40670434
155Staphylococcus aureus infection_Homo sapiens_hsa051500.40650601
156N-Glycan biosynthesis_Homo sapiens_hsa005100.40579386

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